IFNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell mediated immunity (GO:0002717)8.56745081
2positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)8.56745081
3positive regulation of interleukin-17 production (GO:0032740)8.25176735
4positive regulation of natural killer cell differentiation (GO:0032825)8.20914526
5* positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)8.08721981
6regulation of natural killer cell mediated immunity (GO:0002715)7.65588084
7regulation of natural killer cell mediated cytotoxicity (GO:0042269)7.65588084
8positive regulation of organelle assembly (GO:1902117)7.32379253
9regulation of lymphocyte chemotaxis (GO:1901623)7.28979204
10positive regulation of leukocyte mediated cytotoxicity (GO:0001912)7.01705995
11positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.99975367
12positive regulation of T cell chemotaxis (GO:0010820)6.98046856
13regulation of T cell chemotaxis (GO:0010819)6.98046856
14activated T cell proliferation (GO:0050798)6.93232522
15* positive regulation of cell killing (GO:0031343)6.52262164
16regulation of natural killer cell differentiation (GO:0032823)6.19773088
17regulation of B cell receptor signaling pathway (GO:0050855)6.14299887
18regulation of leukocyte mediated cytotoxicity (GO:0001910)6.07989027
19dendritic cell differentiation (GO:0097028)6.04949966
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.92495796
21regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.81823342
22positive regulation of immune response to tumor cell (GO:0002839)5.67697211
23regulation of immune response to tumor cell (GO:0002837)5.67697211
24regulation of response to tumor cell (GO:0002834)5.67697211
25positive regulation of response to tumor cell (GO:0002836)5.67697211
26embryonic placenta development (GO:0001892)5.64330120
27interferon-gamma production (GO:0032609)5.62062991
28cellular response to interleukin-15 (GO:0071350)5.61700139
29* regulation of isotype switching to IgG isotypes (GO:0048302)5.55807766
30* regulation of cell killing (GO:0031341)5.55806924
31* regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)5.48651913
32* positive regulation of B cell mediated immunity (GO:0002714)5.48540705
33* positive regulation of immunoglobulin mediated immune response (GO:0002891)5.48540705
34regulation of macrophage derived foam cell differentiation (GO:0010743)5.29842835
35lymphocyte chemotaxis (GO:0048247)5.26593606
36positive regulation of gamma-delta T cell activation (GO:0046645)5.21859140
37regulation of podosome assembly (GO:0071801)5.19666740
38cellular extravasation (GO:0045123)5.00010323
39* regulation of interleukin-17 production (GO:0032660)4.91250973
40positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.90849251
41leukocyte aggregation (GO:0070486)4.89380551
42positive regulation of lymphocyte migration (GO:2000403)4.86588452
43* positive regulation of lymphocyte mediated immunity (GO:0002708)4.82948546
44regulation of immunoglobulin secretion (GO:0051023)4.79704132
45macrophage activation (GO:0042116)4.79142315
46myeloid dendritic cell differentiation (GO:0043011)4.75094838
47response to interleukin-15 (GO:0070672)4.70282281
48positive regulation of humoral immune response (GO:0002922)4.70065742
49negative regulation of macrophage differentiation (GO:0045650)4.67645453
50positive regulation of T cell mediated cytotoxicity (GO:0001916)4.65131445
51negative regulation of execution phase of apoptosis (GO:1900118)4.55965843
52* positive regulation of isotype switching (GO:0045830)4.55051732
53maturation of 5.8S rRNA (GO:0000460)4.54852283
54viral mRNA export from host cell nucleus (GO:0046784)4.54607627
55positive regulation of interleukin-10 production (GO:0032733)4.49767147
56T cell migration (GO:0072678)4.43865311
57regulation of gamma-delta T cell differentiation (GO:0045586)4.31590279
58* positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)4.25321848
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25105632
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25105632
61CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.23459212
62myeloid dendritic cell activation (GO:0001773)4.21106892
63regulation of cellular amino acid metabolic process (GO:0006521)4.20810957
64* positive regulation of osteoclast differentiation (GO:0045672)4.15181859
65negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.15105877
66positive regulation of T cell cytokine production (GO:0002726)4.13360278
67T cell costimulation (GO:0031295)4.12561656
68positive regulation of cytokine production involved in immune response (GO:0002720)4.10341222
69regulation of T cell mediated cytotoxicity (GO:0001914)4.09366105
70* regulation of immunoglobulin mediated immune response (GO:0002889)4.06245832
71* positive regulation of leukocyte mediated immunity (GO:0002705)4.04303625
72lymphocyte costimulation (GO:0031294)4.03190548
73negative T cell selection (GO:0043383)3.93368749
74* regulation of B cell mediated immunity (GO:0002712)3.91118669
75negative regulation of T cell mediated immunity (GO:0002710)3.90517675
76positive regulation of interferon-gamma production (GO:0032729)3.90394018
77negative regulation of cell killing (GO:0031342)3.89317136
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.89317136
79cytidine catabolic process (GO:0006216)3.87347114
80cytidine deamination (GO:0009972)3.87347114
81cytidine metabolic process (GO:0046087)3.87347114
82positive T cell selection (GO:0043368)3.86310718
83regulation of natural killer cell activation (GO:0032814)3.85891721
84positive regulation of T-helper 1 type immune response (GO:0002827)3.85590738
85lymphocyte migration (GO:0072676)3.83338858
86* regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.82177848
87negative regulation of T cell receptor signaling pathway (GO:0050860)3.78764062
88regulation of interferon-gamma biosynthetic process (GO:0045072)3.75518736
89* positive regulation of DNA recombination (GO:0045911)3.75480609
90negative regulation of T cell proliferation (GO:0042130)3.72535700
91negative regulation by host of viral transcription (GO:0043922)3.71623913
92regulation of gamma-delta T cell activation (GO:0046643)3.71314414
93regulation of lymphocyte migration (GO:2000401)3.71271327
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.70977507
95* regulation of lymphocyte mediated immunity (GO:0002706)3.70455966
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67998388
97regulation of T cell receptor signaling pathway (GO:0050856)3.67004570
98regulation of regulatory T cell differentiation (GO:0045589)3.66351263
99inflammatory response to antigenic stimulus (GO:0002437)3.65288903
100regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.63045605
101negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)3.62735842
102negative regulation of signal transduction in absence of ligand (GO:1901099)3.62735842
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62412743
104retinal cone cell development (GO:0046549)3.62173043
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.61435156
106positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.60533768
107T cell receptor signaling pathway (GO:0050852)3.59635129
108regulation of memory T cell differentiation (GO:0043380)3.56033919
109lymphocyte apoptotic process (GO:0070227)3.54321791
110pyrimidine ribonucleoside catabolic process (GO:0046133)3.53730010
111* positive regulation of immunoglobulin production (GO:0002639)3.53393735
112tolerance induction (GO:0002507)3.48336772
113* positive regulation of JAK-STAT cascade (GO:0046427)3.48065061
114T cell apoptotic process (GO:0070231)3.45720121
115somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.45690481
116somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.45690481
117isotype switching (GO:0045190)3.45690481
118antigen processing and presentation of endogenous antigen (GO:0019883)3.44824371
119negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43232169
120negative regulation of ligase activity (GO:0051352)3.43232169
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43082036
122* positive regulation of production of molecular mediator of immune response (GO:0002702)3.42591018
123positive regulation of defense response to virus by host (GO:0002230)3.41441303
124T cell proliferation (GO:0042098)3.41181177
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40327120
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.38894271
127positive regulation of T cell migration (GO:2000406)3.37960867
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37862584
129positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.35649597
130signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32256216
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32256216
132* alpha-beta T cell differentiation (GO:0046632)3.31700356
133signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31105819
134signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31105819
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31105819
136positive regulation of B cell proliferation (GO:0030890)3.31073237
137positive regulation of endothelial cell apoptotic process (GO:2000353)3.30847527
138DNA deamination (GO:0045006)3.29557424
139regulation of interleukin-2 biosynthetic process (GO:0045076)3.28795655
140negative regulation of thymocyte apoptotic process (GO:0070244)3.22589698
141positive regulation of tissue remodeling (GO:0034105)3.18789717
142positive regulation of activated T cell proliferation (GO:0042104)3.17547037
143signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16114463
144signal transduction involved in DNA damage checkpoint (GO:0072422)3.16114463
145regulation of interferon-gamma production (GO:0032649)3.15566159
146regulation of interleukin-10 production (GO:0032653)3.15270632
147regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11124614
148retinal rod cell development (GO:0046548)3.10616404
149signal transduction involved in cell cycle checkpoint (GO:0072395)3.10127200
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10019877
151regulation of protein kinase A signaling (GO:0010738)3.06311214
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05539890
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.04061565
154regulation of chronic inflammatory response (GO:0002676)3.03906437
155mucosal-associated lymphoid tissue development (GO:0048537)3.00697183
156Peyers patch development (GO:0048541)3.00697183
157regulation of cellular amine metabolic process (GO:0033238)2.99862067
158regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98951274
159positive regulation of ligase activity (GO:0051351)2.94522093
160GDP-mannose metabolic process (GO:0019673)2.93330223
161negative regulation of B cell proliferation (GO:0030889)2.93029991
162* positive regulation of interleukin-12 production (GO:0032735)2.91906870
163negative regulation of mononuclear cell proliferation (GO:0032945)2.89670546
164negative regulation of lymphocyte proliferation (GO:0050672)2.89670546
165negative regulation of T cell activation (GO:0050868)2.89635240
166anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85591853
167cornea development in camera-type eye (GO:0061303)2.84533664
168* alpha-beta T cell activation (GO:0046631)2.77268541
169regulation of cytokine production involved in inflammatory response (GO:1900015)10.0380042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human8.35522908
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.55661676
3* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.79546765
4* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.47231337
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.34816279
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.09514731
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.91333266
8FLI1_27457419_Chip-Seq_LIVER_Mouse3.62515232
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.60318514
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59131263
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52180063
12RUNX_20019798_ChIP-Seq_JUKART_Human3.41295248
13PCGF2_27294783_Chip-Seq_ESCs_Mouse3.10823732
14RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09912413
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.77799099
16MYB_26560356_Chip-Seq_TH2_Human2.67555295
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.65797550
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.48198880
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47109711
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42858112
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.32248008
22* MAF_26560356_Chip-Seq_TH1_Human2.32026691
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11222368
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10308529
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07352637
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05113970
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03357403
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.02850453
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.02802791
30BP1_19119308_ChIP-ChIP_Hs578T_Human10.1340906
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.97926027
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95410526
33VDR_23849224_ChIP-Seq_CD4+_Human1.93423304
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92374465
35MYB_26560356_Chip-Seq_TH1_Human1.87514097
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82952460
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.76509054
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72113329
39GATA3_27048872_Chip-Seq_THYMUS_Human1.68437819
40UTX_26944678_Chip-Seq_JUKART_Human1.64863619
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59500184
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.56358839
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50185029
44GATA3_26560356_Chip-Seq_TH2_Human1.49249575
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45843441
46DCP1A_22483619_ChIP-Seq_HELA_Human1.44522256
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.44388081
48MAF_26560356_Chip-Seq_TH2_Human1.43314935
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40341357
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40020900
51FOXP3_21729870_ChIP-Seq_TREG_Human1.38814405
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38513077
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.37773719
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.36675782
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35950866
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35045667
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33747350
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33422401
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33403425
60GATA1_22025678_ChIP-Seq_K562_Human1.33053220
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32454260
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29561763
63MYC_22102868_ChIP-Seq_BL_Human1.26468631
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21824051
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21805984
66ELK1_19687146_ChIP-ChIP_HELA_Human1.21092954
67VDR_24763502_ChIP-Seq_THP-1_Human1.18464119
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17806981
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15935990
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.15862759
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14523998
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13126012
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.12979383
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12266775
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.07093408
76GABP_19822575_ChIP-Seq_HepG2_Human1.05832785
77SPI1_23127762_ChIP-Seq_K562_Human1.05322856
78VDR_21846776_ChIP-Seq_THP-1_Human1.04138195
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03118272
80SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02277167
81SPI1_23547873_ChIP-Seq_NB4_Human1.01535688
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00205523
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98994249
84TCF7_22412390_ChIP-Seq_EML_Mouse0.98308731
85SOX2_18555785_Chip-Seq_ESCs_Mouse0.97449421
86EGR1_19032775_ChIP-ChIP_M12_Human0.95873847
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.95182890
88VDR_24787735_ChIP-Seq_THP-1_Human0.94743694
89PU_27001747_Chip-Seq_BMDM_Mouse0.94209521
90KLF4_18555785_Chip-Seq_ESCs_Mouse0.94119180
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92881389
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92714977
93P300_18555785_Chip-Seq_ESCs_Mouse0.92429782
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92246517
95HTT_18923047_ChIP-ChIP_STHdh_Human0.91954828
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.91521803
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91463236
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91400808
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90742725
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90655257
101OCT4_18555785_Chip-Seq_ESCs_Mouse0.89511102
102* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.88385655
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86669070
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86640008
105* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86539047
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84934253
107* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84413749
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84212245
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83839537
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83125531
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81992928
112ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81981573
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81678080
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80934121
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80427481
116SPI1_26923725_Chip-Seq_HPCs_Mouse0.80417179
117E2F4_17652178_ChIP-ChIP_JURKAT_Human0.79741172
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78880614
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.78189187
120ZFX_18555785_Chip-Seq_ESCs_Mouse0.77980228
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77936844
122SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75655006
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75497857
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75305612
125CTCF_18555785_Chip-Seq_ESCs_Mouse0.74955040
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.74934589
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.73949766
128ZNF274_21170338_ChIP-Seq_K562_Hela0.73076415
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73073849
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73006063
131TAF15_26573619_Chip-Seq_HEK293_Human0.72343032
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72145063
133RXR_22108803_ChIP-Seq_LS180_Human0.71833759
134MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71478994
135* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.70753091
136ELF5_23300383_ChIP-Seq_T47D_Human0.70140142
137GATA1_19941826_ChIP-Seq_K562_Human0.69489222
138SALL4_22934838_ChIP-ChIP_CD34+_Human0.69324543
139SPI1_20517297_ChIP-Seq_HL60_Human0.68803377
140RUNX1_27457419_Chip-Seq_LIVER_Mouse0.68523894
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.68004282
142MYC_18555785_ChIP-Seq_MESCs_Mouse0.67977850
143GATA3_26560356_Chip-Seq_TH1_Human0.67692382
144TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67222723
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.65375253
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.64255093
147* CEBPB_22108803_ChIP-Seq_LS180_Human0.63663234
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.63027601
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62449779
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61379455
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.59893898
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.59510560
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58878307
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.58772756
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.58477085
156SCL_19346495_ChIP-Seq_HPC-7_Human0.58416265
157SMRT_27268052_Chip-Seq_Bcells_Human0.57778210
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.56458033
159* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.56279395
160EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.55932738
161HOXB4_20404135_ChIP-ChIP_EML_Mouse0.55733602
162GATA2_22383799_ChIP-Seq_G1ME_Mouse0.55410761
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.55346357
164DROSHA_22980978_ChIP-Seq_HELA_Human0.54583630
165SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.53083383
166TCF4_22108803_ChIP-Seq_LS180_Human0.51230841
167RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.51220101
168GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51142451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005671_abnormal_response_to6.81204519
2MP0003763_abnormal_thymus_physiology5.07560641
3MP0003300_gastrointestinal_ulcer4.02804732
4* MP0001835_abnormal_antigen_presentation3.88886245
5* MP0009785_altered_susceptibility_to3.64324899
6* MP0005000_abnormal_immune_tolerance3.34806460
7MP0006082_CNS_inflammation3.28078745
8* MP0001800_abnormal_humoral_immune3.21982176
9* MP0002405_respiratory_system_inflammati3.06864254
10MP0005025_abnormal_response_to3.06398682
11MP0003436_decreased_susceptibility_to2.84385053
12* MP0002723_abnormal_immune_serum2.79386346
13MP0010234_abnormal_vibrissa_follicle2.76485321
14* MP0002420_abnormal_adaptive_immunity2.74335396
15MP0002398_abnormal_bone_marrow2.58701467
16* MP0002452_abnormal_antigen_presenting2.52610289
17* MP0001819_abnormal_immune_cell2.51491981
18MP0000716_abnormal_immune_system2.35118156
19MP0003045_fibrosis2.33987795
20MP0001958_emphysema2.33156248
21* MP0009333_abnormal_splenocyte_physiolog2.32681464
22MP0004782_abnormal_surfactant_physiolog2.27956287
23MP0001853_heart_inflammation2.24818311
24MP0005387_immune_system_phenotype2.07889151
25MP0001790_abnormal_immune_system2.07889151
26MP0000685_abnormal_immune_system2.01962818
27* MP0000689_abnormal_spleen_morphology2.01496655
28* MP0002419_abnormal_innate_immunity1.99915193
29* MP0000703_abnormal_thymus_morphology1.98725542
30* MP0002429_abnormal_blood_cell1.84801527
31* MP0002722_abnormal_immune_system1.82132337
32* MP0001845_abnormal_inflammatory_respons1.80238646
33MP0000465_gastrointestinal_hemorrhage1.75562665
34* MP0010155_abnormal_intestine_physiology1.61363022
35MP0008875_abnormal_xenobiotic_pharmacok1.57179963
36MP0002933_joint_inflammation1.57138160
37MP0003724_increased_susceptibility_to1.56351813
38MP0009780_abnormal_chondrocyte_physiolo1.52368902
39MP0002166_altered_tumor_susceptibility1.51763532
40MP0009764_decreased_sensitivity_to1.51758723
41MP0002006_tumorigenesis1.51728401
42MP0004947_skin_inflammation1.50620430
43* MP0008469_abnormal_protein_level1.49572328
44MP0003329_amyloid_beta_deposits1.43997497
45* MP0005166_decreased_susceptibility_to1.40836043
46* MP0002148_abnormal_hypersensitivity_rea1.34781643
47MP0005085_abnormal_gallbladder_physiolo1.33988193
48* MP0003448_altered_tumor_morphology1.32404610
49MP0000604_amyloidosis1.26619083
50MP0002998_abnormal_bone_remodeling1.25083324
51MP0001533_abnormal_skeleton_physiology1.21176080
52MP0004510_myositis1.20878250
53MP0003950_abnormal_plasma_membrane1.16161044
54MP0001851_eye_inflammation1.13033597
55MP0005360_urolithiasis1.10168412
56MP0002396_abnormal_hematopoietic_system1.04009058
57MP0001501_abnormal_sleep_pattern1.02278176
58MP0005464_abnormal_platelet_physiology1.02085755
59MP0001984_abnormal_olfaction1.01255014
60MP0003303_peritoneal_inflammation1.01089099
61MP0003866_abnormal_defecation1.01015542
62MP0002138_abnormal_hepatobiliary_system1.00489385
63MP0003806_abnormal_nucleotide_metabolis1.00197844
64MP0000920_abnormal_myelination0.96136599
65MP0005408_hypopigmentation0.96107128
66MP0000858_altered_metastatic_potential0.94207894
67MP0002139_abnormal_hepatobiliary_system0.92783465
68MP0000372_irregular_coat_pigmentation0.90698163
69MP0008872_abnormal_physiological_respon0.88919628
70MP0005076_abnormal_cell_differentiation0.88762976
71MP0002168_other_aberrant_phenotype0.86915190
72MP0002133_abnormal_respiratory_system0.82213198
73MP0005388_respiratory_system_phenotype0.82213198
74* MP0001663_abnormal_digestive_system0.81814404
75MP0005390_skeleton_phenotype0.80842464
76MP0004859_abnormal_synaptic_plasticity0.80332151
77* MP0001873_stomach_inflammation0.78611945
78* MP0002136_abnormal_kidney_physiology0.78329731
79MP0000249_abnormal_blood_vessel0.77394750
80MP0004142_abnormal_muscle_tone0.76959335
81MP0005551_abnormal_eye_electrophysiolog0.76918346
82MP0001502_abnormal_circadian_rhythm0.74855031
83* MP0002693_abnormal_pancreas_physiology0.73904518
84* MP0000609_abnormal_liver_physiology0.72887456
85MP0000569_abnormal_digit_pigmentation0.72532956
86MP0002234_abnormal_pharynx_morphology0.71637533
87MP0002876_abnormal_thyroid_physiology0.71447718
88* MP0010307_abnormal_tumor_latency0.71345864
89MP0009763_increased_sensitivity_to0.70855713
90MP0003195_calcinosis0.70115402
91MP0004130_abnormal_muscle_cell0.69117520
92MP0009697_abnormal_copulation0.68967075
93MP0001243_abnormal_dermal_layer0.67637361
94MP0001119_abnormal_female_reproductive0.64887038
95MP0002132_abnormal_respiratory_system0.64464535
96MP0009745_abnormal_behavioral_response0.63339671
97MP0005584_abnormal_enzyme/coenzyme_acti0.62922096
98MP0008873_increased_physiological_sensi0.61828672
99MP0001666_abnormal_nutrient_absorption0.60186431
100MP0004270_analgesia0.56291134
101* MP0002019_abnormal_tumor_incidence0.56107745
102MP0002877_abnormal_melanocyte_morpholog0.54140477
103MP0004957_abnormal_blastocyst_morpholog0.53751839
104MP0002089_abnormal_postnatal_growth/wei0.53720725
105MP0008961_abnormal_basal_metabolism0.53417653
106MP0002163_abnormal_gland_morphology0.52709206
107MP0001915_intracranial_hemorrhage0.51251755
108MP0003943_abnormal_hepatobiliary_system0.49138768
109MP0002277_abnormal_respiratory_mucosa0.47977960
110MP0003635_abnormal_synaptic_transmissio0.47839172
111MP0004197_abnormal_fetal_growth/weight/0.45971817
112MP0000490_abnormal_crypts_of0.45630376
113MP0000613_abnormal_salivary_gland0.45470105
114MP0004233_abnormal_muscle_weight0.45459652
115MP0001986_abnormal_taste_sensitivity0.44471556
116MP0001348_abnormal_lacrimal_gland0.44296251
117* MP0009642_abnormal_blood_homeostasis0.44265021
118MP0006036_abnormal_mitochondrial_physio0.44207305
119MP0010329_abnormal_lipoprotein_level0.44005862
120* MP0005381_digestive/alimentary_phenotyp0.43290582
121MP0005365_abnormal_bile_salt0.43181500
122MP0002210_abnormal_sex_determination0.42794672
123MP0001764_abnormal_homeostasis0.42428164
124MP0005332_abnormal_amino_acid0.41317188
125MP0005310_abnormal_salivary_gland0.41316348
126MP0001905_abnormal_dopamine_level0.41310260
127MP0005165_increased_susceptibility_to0.41181906
128MP0002736_abnormal_nociception_after0.40550877
129* MP0002083_premature_death0.40180515
130* MP0009643_abnormal_urine_homeostasis0.39503587
131* MP0000598_abnormal_liver_morphology0.39254902
132MP0003252_abnormal_bile_duct0.39078643
133MP0003453_abnormal_keratinocyte_physiol0.38416581
134MP0003795_abnormal_bone_structure0.38039593
135MP0001919_abnormal_reproductive_system0.35890348
136MP0002254_reproductive_system_inflammat0.35147042
137MP0006035_abnormal_mitochondrial_morpho0.34638852
138MP0001485_abnormal_pinna_reflex0.34039156
139MP0003880_abnormal_central_pattern0.33942312
140MP0001324_abnormal_eye_pigmentation0.31223733
141* MP0001881_abnormal_mammary_gland0.30310715
142MP0000383_abnormal_hair_follicle0.30054901
143MP0001849_ear_inflammation0.28135806
144MP0005636_abnormal_mineral_homeostasis0.28042240
145MP0000427_abnormal_hair_cycle0.27230876
146MP0000639_abnormal_adrenal_gland0.26520654
147MP0000371_diluted_coat_color0.25903404
148MP0001968_abnormal_touch/_nociception0.25806301

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.10389910
2Abnormality of T cell number (HP:0011839)8.83149082
3Chronic diarrhea (HP:0002028)8.02933457
4IgA deficiency (HP:0002720)7.62863119
5Gastrointestinal infarctions (HP:0005244)7.30422040
6Diplopia (HP:0000651)5.33609634
7Abnormality of binocular vision (HP:0011514)5.33609634
8Inflammation of the large intestine (HP:0002037)4.99550846
9Gastrointestinal inflammation (HP:0004386)4.63602620
10Biconcave vertebral bodies (HP:0004586)4.48535924
11Stomatitis (HP:0010280)4.39205988
12Mediastinal lymphadenopathy (HP:0100721)4.34879811
13Abnormality of T cells (HP:0002843)4.28883549
14Elevated erythrocyte sedimentation rate (HP:0003565)4.27449517
15Abnormality of the pons (HP:0007361)4.18631856
16Abnormality of the prostate (HP:0008775)4.14888997
17Joint swelling (HP:0001386)4.04822761
18Combined immunodeficiency (HP:0005387)3.96706909
19Abnormality of T cell physiology (HP:0011840)3.94455935
20Recurrent bronchitis (HP:0002837)3.92016736
21Delayed epiphyseal ossification (HP:0002663)3.91858092
22Arterial thrombosis (HP:0004420)3.89102616
23Amaurosis fugax (HP:0100576)3.87272672
24Pulmonary infiltrates (HP:0002113)3.82804346
25Severe combined immunodeficiency (HP:0004430)3.77088967
26Hypoplasia of the pons (HP:0012110)3.73864088
27Autoimmune hemolytic anemia (HP:0001890)3.67906502
28Rectal prolapse (HP:0002035)3.67724728
29Ureteral stenosis (HP:0000071)3.61370152
30Chest pain (HP:0100749)3.58335739
31Hypoplasia of the thymus (HP:0000778)3.56460169
32Increased IgM level (HP:0003496)3.52726273
33Hypoproteinemia (HP:0003075)3.52491304
34Obstructive lung disease (HP:0006536)3.52022901
35Chronic obstructive pulmonary disease (HP:0006510)3.52022901
36Carpal bone hypoplasia (HP:0001498)3.45652590
37Aortic dissection (HP:0002647)3.44410321
38Pulmonary embolism (HP:0002204)3.29169875
39IgG deficiency (HP:0004315)3.28661580
40Gangrene (HP:0100758)3.24936142
41Flat capital femoral epiphysis (HP:0003370)3.21756022
42Ureteral obstruction (HP:0006000)3.21421133
43Increased serum pyruvate (HP:0003542)3.16203440
44Birth length less than 3rd percentile (HP:0003561)3.15651647
45Attenuation of retinal blood vessels (HP:0007843)3.15224481
46Thyroiditis (HP:0100646)3.05770485
47Abnormality of eosinophils (HP:0001879)3.05036700
48Vasculitis (HP:0002633)3.03607371
49Anorexia (HP:0002039)3.00002710
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.91965352
51Cheilitis (HP:0100825)2.84240569
52Submucous cleft hard palate (HP:0000176)2.83252120
53Oligomenorrhea (HP:0000876)2.73291624
54Myositis (HP:0100614)2.70241042
55Keratoconjunctivitis (HP:0001096)2.69257451
56Small epiphyses (HP:0010585)2.63472753
57Thrombocytosis (HP:0001894)2.61429853
58Abnormality of glycolysis (HP:0004366)2.60609573
59Abnormality of the lumbar spine (HP:0100712)2.57768372
60Cutaneous melanoma (HP:0012056)2.56154827
61Thrombophlebitis (HP:0004418)2.55696733
62Leukocytosis (HP:0001974)2.52464512
63Acute necrotizing encephalopathy (HP:0006965)2.51653910
64Delayed closure of the anterior fontanelle (HP:0001476)2.49436168
65Acrocyanosis (HP:0001063)2.47315454
66Dilatation of the ascending aorta (HP:0005111)2.46216738
67Muscle fiber atrophy (HP:0100295)2.45409022
68Keratoconjunctivitis sicca (HP:0001097)2.44153756
69IgM deficiency (HP:0002850)2.43125618
70Abnormal glucose tolerance (HP:0001952)2.42731287
71Recurrent viral infections (HP:0004429)2.42675001
72Meningitis (HP:0001287)2.41502857
73Periorbital edema (HP:0100539)2.41174992
74B lymphocytopenia (HP:0010976)2.41099025
75Abnormality of B cell number (HP:0010975)2.41099025
76Hypergammaglobulinemia (HP:0010702)2.40960753
77Reduced antithrombin III activity (HP:0001976)2.40563877
78Facial edema (HP:0000282)2.40080596
79Hemoptysis (HP:0002105)2.40075494
80Deep palmar crease (HP:0006191)2.39884115
81Enlarged epiphyses (HP:0010580)2.38535640
82Mitochondrial inheritance (HP:0001427)2.36143204
83Hypoalbuminemia (HP:0003073)2.35762953
84Abnormal albumin level (HP:0012116)2.35762953
85Multiple enchondromatosis (HP:0005701)2.34700594
86Type I transferrin isoform profile (HP:0003642)2.34009805
87Abnormal rod and cone electroretinograms (HP:0008323)2.31081871
88Irregular vertebral endplates (HP:0003301)2.30561620
89Agammaglobulinemia (HP:0004432)2.30439163
90Type 2 muscle fiber atrophy (HP:0003554)2.29223530
91Abnormality of the pleura (HP:0002103)2.27977298
92Gingival bleeding (HP:0000225)2.27501702
93Absent epiphyses (HP:0010577)2.26903326
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.26903326
95Premature skin wrinkling (HP:0100678)2.23621866
96Metaphyseal irregularity (HP:0003025)2.23369807
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22605420
98Chronic mucocutaneous candidiasis (HP:0002728)2.20697143
99Recurrent cutaneous fungal infections (HP:0011370)2.20697143
100Lymphopenia (HP:0001888)2.18985936
101Opisthotonus (HP:0002179)2.18710412
102Alveolar cell carcinoma (HP:0006519)2.18182177
103Persistence of primary teeth (HP:0006335)2.16761904
104Lymphoma (HP:0002665)2.15879433
105Epistaxis (HP:0000421)2.15709561
106Abnormal mitochondria in muscle tissue (HP:0008316)2.15608457
107Aplasia/Hypoplasia of the thymus (HP:0010515)2.14892042
108Abnormality of cells of the lymphoid lineage (HP:0012140)2.14690963
109Abnormality of the proximal phalanges of the hand (HP:0009834)2.14472278
110Increased CSF lactate (HP:0002490)2.13817538
111Abnormality of the nasal septum (HP:0000419)2.12432931
112Keratitis (HP:0000491)2.12262642
113Loss of speech (HP:0002371)2.10085560
114Flat occiput (HP:0005469)2.08818839
115Premature graying of hair (HP:0002216)2.08300683
116Vertebral compression fractures (HP:0002953)2.07686630
117Retrobulbar optic neuritis (HP:0100654)2.06371996
118Optic neuritis (HP:0100653)2.06371996
119Glomerulopathy (HP:0100820)2.06348429
120Abnormality of the vertebral endplates (HP:0005106)2.04492647
121Abnormal delayed hypersensitivity skin test (HP:0002963)2.04327944
122Vertigo (HP:0002321)2.04168917
123Polyneuropathy (HP:0001271)2.03318802
124Aplastic anemia (HP:0001915)2.02231592
125Cerebral hypomyelination (HP:0006808)1.98408509
126Progressive macrocephaly (HP:0004481)1.96827655
127Bronchitis (HP:0012387)1.96072701
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94052915
129Recurrent fungal infections (HP:0002841)1.93505640
130Alkalosis (HP:0001948)1.93341659
131Premature ovarian failure (HP:0008209)1.93198988
132Interstitial pulmonary disease (HP:0006530)1.93125697
133Acute encephalopathy (HP:0006846)1.93074726
134Eosinophilia (HP:0001880)1.92856465
135Neoplasm of the tracheobronchial system (HP:0100552)1.92625327
136Pancreatitis (HP:0001733)1.91870331
137Optic disc pallor (HP:0000543)1.89605922
138Hypertensive crisis (HP:0100735)1.88299364
139Abnormality of male internal genitalia (HP:0000022)1.88054228
140Spastic diplegia (HP:0001264)1.86598178
141Orchitis (HP:0100796)1.86261892
142Pulmonary fibrosis (HP:0002206)1.86082513
143Neutropenia (HP:0001875)1.85293689
144Abnormal number of incisors (HP:0011064)1.84459670
145Hepatocellular necrosis (HP:0001404)1.84301524
146Optic nerve coloboma (HP:0000588)1.82723252
147Inability to walk (HP:0002540)1.81637394
148Autoimmune thrombocytopenia (HP:0001973)1.81359536
149Abnormality of the pericardium (HP:0001697)1.81259812
150Nasal polyposis (HP:0100582)1.80384924
151Abnormal platelet volume (HP:0011876)1.74353612
152Glucose intolerance (HP:0000833)1.73940542
153Restrictive lung disease (HP:0002091)1.72467531
154Thoracolumbar scoliosis (HP:0002944)1.70953665
155Sepsis (HP:0100806)1.69221715
156Entropion (HP:0000621)1.67854402
157Scanning speech (HP:0002168)1.66137420
158Redundant skin (HP:0001582)1.64999389
159Insulin-resistant diabetes mellitus (HP:0000831)1.63087256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.37741234
2MAP3K126.30519134
3NME16.11289371
4RIPK15.21946139
5EIF2AK34.61341397
6ITK3.90232106
7BMPR23.65598630
8PIK3CA3.60215264
9MAP4K13.26968134
10MAP3K142.98751044
11EIF2AK12.98063717
12PKN22.47251411
13MAP2K62.46345345
14MYLK2.32955779
15CDC72.30803034
16PAK42.29943286
17CSK2.24836791
18EPHB12.16483094
19TNK22.09322906
20IRAK42.04218918
21WNK11.91993400
22JAK31.83119870
23IRAK21.78553279
24FLT31.77864511
25IKBKE1.74616388
26TBK11.71177611
27VRK21.64125188
28LCK1.58520850
29BTK1.57430528
30FGFR31.54597532
31PIM21.54424228
32TEC1.40871892
33ADRBK21.38348907
34ZAP701.33902405
35IKBKB1.28647201
36FGFR11.17830460
37IRAK11.16455654
38HCK1.06920010
39FYN0.92241537
40FES0.90480548
41TSSK60.87581504
42DAPK10.86710220
43CLK10.85507019
44TLK10.84939916
45LYN0.83298093
46MAP3K50.83236560
47ZAK0.83199998
48PINK10.82438838
49MST40.81484061
50AKT30.81476798
51PRKD30.80618012
52CSNK1A1L0.79087933
53SYK0.77375698
54ROCK20.75289081
55VRK10.74973231
56PLK30.73049450
57GRK60.72131954
58PTK60.67327393
59BUB10.65824114
60CAMKK20.65272590
61JAK10.63522272
62WNK40.63201399
63CSNK1G30.62672445
64ILK0.61053665
65PRKCH0.60858051
66PKN10.58478793
67EPHB20.58257472
68STK100.56479402
69DAPK30.56448385
70IGF1R0.54251483
71INSR0.53841649
72PDK10.53814486
73GSK3A0.52744947
74FGFR40.51547960
75BLK0.48714435
76PAK20.48215795
77ADRBK10.47695003
78GRK10.46958889
79TYK20.45346677
80GRK70.44171501
81RPS6KA10.44147511
82IRAK30.43860944
83LRRK20.43448784
84TTN0.42803741
85RPS6KB10.42077658
86CSNK1G10.40438638
87NUAK10.40317276
88CSNK1G20.39964223
89CAMK1D0.39658709
90NEK60.39330574
91TRIM280.37711418
92PDGFRB0.36644160
93RAF10.36254421
94ALK0.35463535
95BMPR1B0.34753274
96NME20.33266699
97KDR0.32153892
98BCR0.31949393
99PRKCD0.31862788
100PTK2B0.30819826
101CHUK0.30469307
102CDK40.29809439
103EIF2AK20.29406924
104CAMKK10.28905327
105STK240.28151880
106MAP3K70.28078974
107TAOK30.26984922
108SRC0.26945816
109MAPKAPK20.25911573
110MELK0.25324982
111ERBB30.25061222
112MTOR0.25031798
113ABL10.24435152
114BRSK10.23701671
115KIT0.22567114
116NEK10.22347323
117PDPK10.22065075
118MAPK90.21997674
119TTK0.21279908
120PRKCA0.20993952
121CSNK1A10.20008442
122MAP2K70.19894553
123EGFR0.19875672
124MAPK100.19412088
125PRKCB0.19381207
126PIM10.17969756
127CDK50.16475081
128MAP3K110.16202941
129STK40.16079107
130PRKCQ0.15514269
131RIPK40.15483923
132SIK20.15265809
133PRKG20.14945682
134CSNK2A20.14704994
135PTK20.14687192
136MAPK80.14089618
137RPS6KB20.13625743
138MAPK30.13308791
139BRSK20.12843508
140SRPK10.12651861
141ATR0.12405362
142CSNK1E0.12209815
143JAK20.11173080
144BCKDK0.10964695
145ACVR1B0.10051324
146CAMK2B0.09746802
147RPS6KA30.09648697
148PRKDC0.09022794
149STK390.08981191
150PRKACA0.08909686
151DAPK20.08209796
152STK110.07940167

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053327.92936635
2* Proteasome_Homo sapiens_hsa030506.23917038
3* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.94677576
4* Allograft rejection_Homo sapiens_hsa053303.90241506
5* Type I diabetes mellitus_Homo sapiens_hsa049403.81533585
6* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.72354862
7* T cell receptor signaling pathway_Homo sapiens_hsa046603.46145776
8* Antigen processing and presentation_Homo sapiens_hsa046123.32930915
9Caffeine metabolism_Homo sapiens_hsa002323.02709683
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.92172943
11Primary immunodeficiency_Homo sapiens_hsa053402.31938306
12* Jak-STAT signaling pathway_Homo sapiens_hsa046302.25434860
13Asthma_Homo sapiens_hsa053102.24324598
14Autoimmune thyroid disease_Homo sapiens_hsa053202.08127448
15Hematopoietic cell lineage_Homo sapiens_hsa046402.04783048
16* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.85702478
17* Measles_Homo sapiens_hsa051621.73103336
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58341865
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57183095
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56354740
21RNA polymerase_Homo sapiens_hsa030201.43363753
22Nitrogen metabolism_Homo sapiens_hsa009101.41734750
23Folate biosynthesis_Homo sapiens_hsa007901.39779436
24One carbon pool by folate_Homo sapiens_hsa006701.32435889
25TNF signaling pathway_Homo sapiens_hsa046681.31942952
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31924181
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31794831
28* Salmonella infection_Homo sapiens_hsa051321.28790365
29Apoptosis_Homo sapiens_hsa042101.25195419
30Chemokine signaling pathway_Homo sapiens_hsa040621.22724412
31Viral myocarditis_Homo sapiens_hsa054161.16395660
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.14896275
33* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05774535
34Vitamin B6 metabolism_Homo sapiens_hsa007501.04867548
35* Leishmaniasis_Homo sapiens_hsa051401.03394868
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94974326
37B cell receptor signaling pathway_Homo sapiens_hsa046620.94964068
38Intestinal immune network for IgA production_Homo sapiens_hsa046720.90522383
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86485402
40RNA degradation_Homo sapiens_hsa030180.81990383
41* African trypanosomiasis_Homo sapiens_hsa051430.81374590
42* Osteoclast differentiation_Homo sapiens_hsa043800.80809935
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79216727
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78979469
45HTLV-I infection_Homo sapiens_hsa051660.78893478
46Butanoate metabolism_Homo sapiens_hsa006500.78013903
47* Rheumatoid arthritis_Homo sapiens_hsa053230.77234293
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.76262867
49Linoleic acid metabolism_Homo sapiens_hsa005910.73620488
50* Herpes simplex infection_Homo sapiens_hsa051680.72332972
51Basal transcription factors_Homo sapiens_hsa030220.70356584
52Staphylococcus aureus infection_Homo sapiens_hsa051500.70258030
53N-Glycan biosynthesis_Homo sapiens_hsa005100.66011267
54Hepatitis C_Homo sapiens_hsa051600.64428073
55Pyrimidine metabolism_Homo sapiens_hsa002400.63821028
56Homologous recombination_Homo sapiens_hsa034400.63042444
57Fructose and mannose metabolism_Homo sapiens_hsa000510.62150172
58VEGF signaling pathway_Homo sapiens_hsa043700.60517104
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59429620
60Steroid biosynthesis_Homo sapiens_hsa001000.59198853
61* Malaria_Homo sapiens_hsa051440.57381655
62RNA transport_Homo sapiens_hsa030130.57014971
63* Toxoplasmosis_Homo sapiens_hsa051450.56354615
64Sulfur relay system_Homo sapiens_hsa041220.54535151
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54523977
66Oxidative phosphorylation_Homo sapiens_hsa001900.53682415
67Pentose phosphate pathway_Homo sapiens_hsa000300.53502557
68Thyroid cancer_Homo sapiens_hsa052160.53015029
69Spliceosome_Homo sapiens_hsa030400.52695257
70* Amoebiasis_Homo sapiens_hsa051460.52578493
71Phototransduction_Homo sapiens_hsa047440.52147908
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51815755
73Long-term potentiation_Homo sapiens_hsa047200.50742642
74Viral carcinogenesis_Homo sapiens_hsa052030.48389965
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47479811
76Parkinsons disease_Homo sapiens_hsa050120.47269165
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46171127
78Protein export_Homo sapiens_hsa030600.44988445
79Arginine biosynthesis_Homo sapiens_hsa002200.42097129
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40272480
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39609048
82Endocytosis_Homo sapiens_hsa041440.39167470
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39061656
84Pertussis_Homo sapiens_hsa051330.39045652
85Platelet activation_Homo sapiens_hsa046110.38734148
86mTOR signaling pathway_Homo sapiens_hsa041500.35751543
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35368927
88Small cell lung cancer_Homo sapiens_hsa052220.34881437
89Hepatitis B_Homo sapiens_hsa051610.34131324
90Purine metabolism_Homo sapiens_hsa002300.33737344
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33522701
92Acute myeloid leukemia_Homo sapiens_hsa052210.33293225
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32985620
94Legionellosis_Homo sapiens_hsa051340.31496879
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.31486070
96MAPK signaling pathway_Homo sapiens_hsa040100.31439969
97Peroxisome_Homo sapiens_hsa041460.30868885
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29083018
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27313099
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27046851
101* Epstein-Barr virus infection_Homo sapiens_hsa051690.26444943
102Sulfur metabolism_Homo sapiens_hsa009200.24235558
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22794776
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.21274549
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21229470
106Propanoate metabolism_Homo sapiens_hsa006400.18785741
107Arachidonic acid metabolism_Homo sapiens_hsa005900.18619162
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.17446980
109Fanconi anemia pathway_Homo sapiens_hsa034600.17162210
110* Influenza A_Homo sapiens_hsa051640.17021186
111* Systemic lupus erythematosus_Homo sapiens_hsa053220.16095211
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.15417345
113Vitamin digestion and absorption_Homo sapiens_hsa049770.14642537
114Colorectal cancer_Homo sapiens_hsa052100.14227306
115Circadian rhythm_Homo sapiens_hsa047100.14149014
116Type II diabetes mellitus_Homo sapiens_hsa049300.14142068
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13464612
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.13388784
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.12862810
120Prolactin signaling pathway_Homo sapiens_hsa049170.12733880
121Biosynthesis of amino acids_Homo sapiens_hsa012300.12679232
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12070181
123Pancreatic cancer_Homo sapiens_hsa052120.11827818
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11718410
125Nucleotide excision repair_Homo sapiens_hsa034200.11382435
126Ribosome_Homo sapiens_hsa030100.11294608
127Insulin resistance_Homo sapiens_hsa049310.11066821
128Shigellosis_Homo sapiens_hsa051310.10315783
129Focal adhesion_Homo sapiens_hsa045100.09416303
130Adherens junction_Homo sapiens_hsa045200.09091889
131Metabolic pathways_Homo sapiens_hsa011000.08194867
132Ether lipid metabolism_Homo sapiens_hsa005650.06810927
133Axon guidance_Homo sapiens_hsa043600.06767238
134* Tuberculosis_Homo sapiens_hsa051520.06502708
135p53 signaling pathway_Homo sapiens_hsa041150.05870736
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05219661
137Rap1 signaling pathway_Homo sapiens_hsa040150.04933659
138Huntingtons disease_Homo sapiens_hsa050160.04527958
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.03568569
140Dilated cardiomyopathy_Homo sapiens_hsa054140.03123592
141Fat digestion and absorption_Homo sapiens_hsa049750.03021882
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02560154
143Complement and coagulation cascades_Homo sapiens_hsa046100.02480568
144Oxytocin signaling pathway_Homo sapiens_hsa049210.02453309
145Glycerolipid metabolism_Homo sapiens_hsa005610.01760696
146Proteoglycans in cancer_Homo sapiens_hsa052050.01539843
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.01237604
148Mineral absorption_Homo sapiens_hsa049780.00732979
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.00329849

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