IFNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic viscerocranium morphogenesis (GO:0048703)7.93098230
2peptide cross-linking (GO:0018149)6.78140927
3negative regulation of dendrite morphogenesis (GO:0050774)6.15288832
4desmosome organization (GO:0002934)5.88562104
5hemidesmosome assembly (GO:0031581)5.41562765
6hydrogen peroxide biosynthetic process (GO:0050665)5.15683799
7negative regulation of dendrite development (GO:2000171)4.85188750
8segment specification (GO:0007379)4.64350799
9reactive oxygen species biosynthetic process (GO:1903409)4.55286759
10regulation of dendritic spine morphogenesis (GO:0061001)4.47007964
11thyroid hormone metabolic process (GO:0042403)4.30736808
12positive regulation of vesicle fusion (GO:0031340)4.06579776
13middle ear morphogenesis (GO:0042474)4.03914239
14establishment of mitochondrion localization (GO:0051654)4.03325414
15osteoblast development (GO:0002076)4.02283114
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.00390108
17mitochondrion transport along microtubule (GO:0047497)4.00390108
18motor neuron axon guidance (GO:0008045)4.00194014
19forebrain morphogenesis (GO:0048853)3.95004662
20endothelium development (GO:0003158)3.90060301
21cardiac epithelial to mesenchymal transition (GO:0060317)3.72671259
22keratinization (GO:0031424)3.60506555
23regulation of glomerular filtration (GO:0003093)3.56923264
24positive regulation of respiratory burst (GO:0060267)3.55679144
25superoxide anion generation (GO:0042554)3.53116867
26negative regulation of erythrocyte differentiation (GO:0045647)3.50127281
27cartilage morphogenesis (GO:0060536)3.46300312
28mammary gland epithelial cell differentiation (GO:0060644)3.44779419
29endoplasmic reticulum organization (GO:0007029)3.42521532
30mesenchymal-epithelial cell signaling (GO:0060638)3.39735052
31thyroid hormone generation (GO:0006590)3.39267704
32positive regulation of synapse maturation (GO:0090129)3.38422221
33neurotransmitter-gated ion channel clustering (GO:0072578)3.33212253
34dendritic spine morphogenesis (GO:0060997)3.32587178
35establishment of skin barrier (GO:0061436)3.31373008
36fat-soluble vitamin catabolic process (GO:0042363)3.27441288
37vitamin catabolic process (GO:0009111)3.27441288
38regulation of dendritic spine development (GO:0060998)3.27056288
39regulation of vesicle fusion (GO:0031338)3.25779031
40ephrin receptor signaling pathway (GO:0048013)3.21988750
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13080971
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.13080971
43modulation by symbiont of host immune response (GO:0052553)3.13080971
44positive regulation by symbiont of host defense response (GO:0052509)3.13080971
45modulation by symbiont of host defense response (GO:0052031)3.13080971
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13080971
47heart valve morphogenesis (GO:0003179)3.11235645
48regulation of synapse maturation (GO:0090128)3.09701938
49neural crest cell development (GO:0014032)3.08911080
50carnitine metabolic process (GO:0009437)3.06916269
51regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.03345099
52negative regulation of cell aging (GO:0090344)2.99911528
53atrial cardiac muscle cell action potential (GO:0086014)2.97213636
54positive regulation of dendritic spine morphogenesis (GO:0061003)2.94477319
55cell proliferation involved in metanephros development (GO:0072203)2.94267256
56protein heterotetramerization (GO:0051290)2.93816786
57positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.91641420
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89347529
59negative regulation of catenin import into nucleus (GO:0035414)2.85448532
60regulation of water loss via skin (GO:0033561)2.84921633
61photoreceptor cell differentiation (GO:0046530)2.83872457
62eye photoreceptor cell differentiation (GO:0001754)2.83872457
63urogenital system development (GO:0001655)2.82666701
64renal system process involved in regulation of blood volume (GO:0001977)2.81470634
65mesenchymal cell development (GO:0014031)2.77620323
66sphingoid metabolic process (GO:0046519)2.76772242
67motile cilium assembly (GO:0044458)2.73089849
68regulation of synaptic vesicle exocytosis (GO:2000300)2.71101405
69positive regulation of fibroblast migration (GO:0010763)2.70606565
70keratinocyte proliferation (GO:0043616)2.68913921
71positive regulation of CREB transcription factor activity (GO:0032793)2.68130196
72positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.67498942
73negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.66818413
74regulation of bile acid biosynthetic process (GO:0070857)2.66309949
75positive regulation of antigen processing and presentation (GO:0002579)2.65634763
76lung secretory cell differentiation (GO:0061140)2.65196521
77regulation of T-helper 1 cell differentiation (GO:0045625)2.64168071
78regulation of cellular senescence (GO:2000772)2.61433386
79cellular potassium ion homeostasis (GO:0030007)2.59486004
80protein targeting to plasma membrane (GO:0072661)2.58617136
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55324998
82fatty acid elongation (GO:0030497)2.53974051
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51741045
84positive regulation of cellular amide metabolic process (GO:0034250)2.51534777
85regulation of somitogenesis (GO:0014807)2.50644945
86sphingosine metabolic process (GO:0006670)2.49295606
87positive regulation of natural killer cell differentiation (GO:0032825)2.49070374
88response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.48125303
89positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45449983
90gap junction assembly (GO:0016264)2.45233846
91vocalization behavior (GO:0071625)2.45165402
92membrane assembly (GO:0071709)2.44101511
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43906006
94positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43857014
95positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43108495
96mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43108495
97retina layer formation (GO:0010842)2.42172715
98oligodendrocyte differentiation (GO:0048709)2.41483375
99protein depolymerization (GO:0051261)2.40863587
100lung epithelial cell differentiation (GO:0060487)2.39044395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.59643645
2EZH2_22144423_ChIP-Seq_EOC_Human3.25779524
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88330004
4IKZF1_21737484_ChIP-ChIP_HCT116_Human2.84414457
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.83672324
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71925476
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.50430315
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47379806
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46559062
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42672346
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41855550
12TAF15_26573619_Chip-Seq_HEK293_Human2.40008132
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30749615
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30749615
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.23724449
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22441284
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14034055
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07253031
19VDR_22108803_ChIP-Seq_LS180_Human2.03896916
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.02742783
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00422607
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.95113043
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84526985
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82585471
25EGR1_19032775_ChIP-ChIP_M12_Human1.82490357
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79981257
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79875789
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77865110
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.72131648
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71744001
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.71198813
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68845816
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.61394409
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57630080
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56760170
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49681413
37P300_19829295_ChIP-Seq_ESCs_Human1.44738656
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.44655145
39* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38104113
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35404661
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28395477
42* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26933873
43AR_21572438_ChIP-Seq_LNCaP_Human1.26590135
44FUS_26573619_Chip-Seq_HEK293_Human1.25246153
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.24434027
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22602286
47DROSHA_22980978_ChIP-Seq_HELA_Human1.20633000
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20618440
49SMAD4_21799915_ChIP-Seq_A2780_Human1.19810185
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19134132
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18555659
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18047481
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17571659
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.16617817
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15537866
56BCAT_22108803_ChIP-Seq_LS180_Human1.14831388
57REST_21632747_ChIP-Seq_MESCs_Mouse1.13587222
58P300_18555785_Chip-Seq_ESCs_Mouse1.13189413
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13133309
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.11641148
61TP53_18474530_ChIP-ChIP_U2OS_Human1.09965568
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07990270
63OCT4_18555785_Chip-Seq_ESCs_Mouse1.06903038
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06726245
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06405191
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.05954192
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.05437764
68ZFX_18555785_Chip-Seq_ESCs_Mouse1.04100699
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03013105
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02801175
71AR_25329375_ChIP-Seq_VCAP_Human0.99097185
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98228336
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.97597391
74ER_23166858_ChIP-Seq_MCF-7_Human0.97150286
75E2F1_18555785_Chip-Seq_ESCs_Mouse0.96964486
76P53_22387025_ChIP-Seq_ESCs_Mouse0.95101174
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94515643
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93616318
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92668061
80NANOG_19829295_ChIP-Seq_ESCs_Human0.92579309
81SOX2_19829295_ChIP-Seq_ESCs_Human0.92579309
82CMYC_18555785_Chip-Seq_ESCs_Mouse0.92397033
83KLF4_18555785_Chip-Seq_ESCs_Mouse0.90540294
84STAT3_23295773_ChIP-Seq_U87_Human0.89992625
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89774150
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89620468
87TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89518105
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.89313512
89JUN_21703547_ChIP-Seq_K562_Human0.89248078
90KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89230827
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89212231
92RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89050876
93CTCF_18555785_Chip-Seq_ESCs_Mouse0.88961481
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88933883
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88098312
96PHF8_20622853_ChIP-Seq_HELA_Human0.86357794
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.86357001
98TCF4_22108803_ChIP-Seq_LS180_Human0.86106264
99AR_19668381_ChIP-Seq_PC3_Human0.86090112
100RNF2_27304074_Chip-Seq_NSC_Mouse0.86030754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology9.14132482
2MP0005451_abnormal_body_composition4.74184213
3MP0003136_yellow_coat_color4.34580211
4MP0003950_abnormal_plasma_membrane3.89050318
5MP0005409_darkened_coat_color3.16445186
6MP0005670_abnormal_white_adipose2.72973558
7MP0000762_abnormal_tongue_morphology2.64755269
8MP0000049_abnormal_middle_ear2.37145963
9MP0010030_abnormal_orbit_morphology2.36033060
10MP0004381_abnormal_hair_follicle2.28778061
11MP0004270_analgesia2.05374989
12MP0001270_distended_abdomen2.02859315
13MP0008789_abnormal_olfactory_epithelium1.94739434
14MP0000015_abnormal_ear_pigmentation1.94669183
15MP0004019_abnormal_vitamin_homeostasis1.94524207
16MP0003880_abnormal_central_pattern1.73877313
17MP0005499_abnormal_olfactory_system1.73002394
18MP0005394_taste/olfaction_phenotype1.73002394
19MP0004859_abnormal_synaptic_plasticity1.70128939
20MP0003011_delayed_dark_adaptation1.66248441
21MP0000372_irregular_coat_pigmentation1.62249044
22MP0000013_abnormal_adipose_tissue1.61298513
23MP0005171_absent_coat_pigmentation1.58471995
24MP0002177_abnormal_outer_ear1.57222622
25MP0005623_abnormal_meninges_morphology1.49956683
26MP0008569_lethality_at_weaning1.44366627
27MP0009046_muscle_twitch1.44198322
28MP0002277_abnormal_respiratory_mucosa1.37873087
29MP0005257_abnormal_intraocular_pressure1.31472640
30MP0002822_catalepsy1.31345489
31MP0000647_abnormal_sebaceous_gland1.30373891
32MP0003195_calcinosis1.30233058
33MP0009745_abnormal_behavioral_response1.29568148
34MP0002938_white_spotting1.29363971
35MP0001188_hyperpigmentation1.25194714
36MP0000427_abnormal_hair_cycle1.24133631
37MP0009379_abnormal_foot_pigmentation1.22254125
38MP0010386_abnormal_urinary_bladder1.21552760
39MP0000569_abnormal_digit_pigmentation1.21087884
40MP0003172_abnormal_lysosome_physiology1.20734705
41MP0003635_abnormal_synaptic_transmissio1.11395737
42MP0000465_gastrointestinal_hemorrhage1.10463284
43MP0001968_abnormal_touch/_nociception1.07431103
44MP0001501_abnormal_sleep_pattern1.07340102
45MP0002064_seizures1.06775109
46MP0004858_abnormal_nervous_system1.05445971
47MP0000751_myopathy1.04671013
48MP0001486_abnormal_startle_reflex1.04032828
49MP0003632_abnormal_nervous_system1.03303704
50MP0005174_abnormal_tail_pigmentation1.01785250
51MP0001664_abnormal_digestion1.00211513
52MP0005386_behavior/neurological_phenoty0.99984913
53MP0004924_abnormal_behavior0.99984913
54MP0002272_abnormal_nervous_system0.98368750
55MP0003690_abnormal_glial_cell0.97751235
56MP0005508_abnormal_skeleton_morphology0.97134664
57MP0006292_abnormal_olfactory_placode0.95671169
58MP0002249_abnormal_larynx_morphology0.94552512
59MP0002972_abnormal_cardiac_muscle0.94516602
60MP0005187_abnormal_penis_morphology0.93560783
61MP0003718_maternal_effect0.91288005
62MP0000428_abnormal_craniofacial_morphol0.87310957
63MP0005620_abnormal_muscle_contractility0.85778139
64MP0005551_abnormal_eye_electrophysiolog0.83206589
65MP0001485_abnormal_pinna_reflex0.83133253
66MP0001502_abnormal_circadian_rhythm0.83038341
67MP0003566_abnormal_cell_adhesion0.82804004
68MP0002736_abnormal_nociception_after0.82705860
69MP0001851_eye_inflammation0.82546311
70MP0010678_abnormal_skin_adnexa0.81200282
71MP0002233_abnormal_nose_morphology0.79370216
72MP0002572_abnormal_emotion/affect_behav0.78493981
73MP0002896_abnormal_bone_mineralization0.77248784
74MP0003137_abnormal_impulse_conducting0.77001136
75MP0001340_abnormal_eyelid_morphology0.75444118
76MP0001529_abnormal_vocalization0.73583196
77MP0002089_abnormal_postnatal_growth/wei0.72244490
78MP0002734_abnormal_mechanical_nocicepti0.72163378
79MP0004142_abnormal_muscle_tone0.71762766
80MP0004742_abnormal_vestibular_system0.70422053
81MP0000163_abnormal_cartilage_morphology0.70389298
82MP0003755_abnormal_palate_morphology0.69957945
83MP0000026_abnormal_inner_ear0.68123537
84MP0000747_muscle_weakness0.68120963
85MP0002063_abnormal_learning/memory/cond0.67642868
86MP0005381_digestive/alimentary_phenotyp0.66705768
87MP0005248_abnormal_Harderian_gland0.66038678
88MP0000778_abnormal_nervous_system0.65120451
89MP0000383_abnormal_hair_follicle0.61660569
90MP0010771_integument_phenotype0.61619813
91MP0001324_abnormal_eye_pigmentation0.61561122
92MP0005375_adipose_tissue_phenotype0.61502033
93MP0002282_abnormal_trachea_morphology0.61178051
94MP0001663_abnormal_digestive_system0.60747807
95MP0004036_abnormal_muscle_relaxation0.57607421
96MP0008057_abnormal_DNA_replication0.57463599
97MP0001177_atelectasis0.56628140
98MP0005165_increased_susceptibility_to0.56401785
99MP0000230_abnormal_systemic_arterial0.55686067
100MP0001984_abnormal_olfaction0.55013466

Predicted human phenotypes

RankGene SetZ-score
1Mixed hearing impairment (HP:0000410)7.08976615
2Erythema (HP:0010783)6.69484981
3Fragile nails (HP:0001808)5.82517341
4Distal lower limb muscle weakness (HP:0009053)5.51492119
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.72846664
6Alopecia of scalp (HP:0002293)4.39664163
7Follicular hyperkeratosis (HP:0007502)4.23933689
8Hyporeflexia of lower limbs (HP:0002600)3.91532491
9Hyperventilation (HP:0002883)3.81650796
10Focal motor seizures (HP:0011153)3.63693795
11Congenital sensorineural hearing impairment (HP:0008527)3.62213068
12Milia (HP:0001056)3.42610300
13Aplasia cutis congenita (HP:0001057)3.42394509
14Steppage gait (HP:0003376)3.42255484
15Septate vagina (HP:0001153)3.39915626
16Patchy hypopigmentation of hair (HP:0011365)3.24235942
17Onycholysis (HP:0001806)3.23680531
18Osteomalacia (HP:0002749)3.16850558
19Concave nail (HP:0001598)3.16771088
20Abnormal blistering of the skin (HP:0008066)3.15597297
21Neonatal short-limb short stature (HP:0008921)3.12185947
22Atrophic scars (HP:0001075)3.09724897
23White forelock (HP:0002211)3.08447242
24Aplasia involving bones of the extremities (HP:0009825)3.05605231
25Aplasia involving bones of the upper limbs (HP:0009823)3.05605231
26Aplasia of the phalanges of the hand (HP:0009802)3.05605231
27Plantar hyperkeratosis (HP:0007556)2.89077861
28Febrile seizures (HP:0002373)2.87871774
29Sensory axonal neuropathy (HP:0003390)2.86136438
30Delayed CNS myelination (HP:0002188)2.82981428
31Hypophosphatemic rickets (HP:0004912)2.77831278
32Hydroureter (HP:0000072)2.71210606
33Sparse eyelashes (HP:0000653)2.69611635
34Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.67368425
35Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.64862994
36Neurofibrillary tangles (HP:0002185)2.63587782
37Epileptic encephalopathy (HP:0200134)2.63221339
38Xerostomia (HP:0000217)2.56927421
39Dialeptic seizures (HP:0011146)2.55939195
40Focal seizures (HP:0007359)2.47424220
41Abnormality of calcium-phosphate metabolism (HP:0100530)2.42408432
42Woolly hair (HP:0002224)2.41197480
43Pili torti (HP:0003777)2.41162657
44Hypoplastic left heart (HP:0004383)2.35054919
45Methylmalonic acidemia (HP:0002912)2.34852829
46Blepharitis (HP:0000498)2.31228831
47Blue irides (HP:0000635)2.29941138
48Prolonged partial thromboplastin time (HP:0003645)2.29687976
49Hypoplasia of the fovea (HP:0007750)2.28305592
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.28305592
51Stomatitis (HP:0010280)2.27443675
52Keratitis (HP:0000491)2.23034976
53Abnormal sex determination (HP:0012244)2.21476044
54Sex reversal (HP:0012245)2.21476044
55Hypoventilation (HP:0002791)2.19604498
56Down-sloping shoulders (HP:0200021)2.19409915
57Pustule (HP:0200039)2.19139561
58Cerebral inclusion bodies (HP:0100314)2.16845999
59Ulnar claw (HP:0001178)2.14782715
60Hyperinsulinemic hypoglycemia (HP:0000825)2.14057689
61Rectal fistula (HP:0100590)2.12591836
62Rectovaginal fistula (HP:0000143)2.12591836
63Hemiparesis (HP:0001269)2.12552731
64Status epilepticus (HP:0002133)2.11631991
65Abnormal hair laboratory examination (HP:0003328)2.11582629
66Orchitis (HP:0100796)2.04805101
67Hyperphosphatemia (HP:0002905)2.02713944
68Natal tooth (HP:0000695)1.99445294
69Neoplasm of the heart (HP:0100544)1.99062464
70Abnormality of the calf musculature (HP:0001430)1.97021457
71Hypodontia (HP:0000668)1.96836206
72Areflexia of lower limbs (HP:0002522)1.95872032
73Flat capital femoral epiphysis (HP:0003370)1.94610476
74Urethral obstruction (HP:0000796)1.92349901
75Methylmalonic aciduria (HP:0012120)1.90195750
76Amelogenesis imperfecta (HP:0000705)1.87996817
77Increased hepatocellular lipid droplets (HP:0006565)1.87637053
78Tibial bowing (HP:0002982)1.87626067
79Complete atrioventricular canal defect (HP:0001674)1.87263303
80Thick nail (HP:0001805)1.87208664
81Absence seizures (HP:0002121)1.86535934
82Retrobulbar optic neuritis (HP:0100654)1.84385622
83Optic neuritis (HP:0100653)1.84385622
84Onion bulb formation (HP:0003383)1.82801310
85Abnormality of the dental root (HP:0006486)1.82264386
86Taurodontia (HP:0000679)1.82264386
87Abnormality of permanent molar morphology (HP:0011071)1.82264386
88Shoulder girdle muscle weakness (HP:0003547)1.81926348
89Atrioventricular canal defect (HP:0006695)1.81424567
90Ectropion (HP:0000656)1.81120901
91Hypoplastic heart (HP:0001961)1.80657584
92Foot dorsiflexor weakness (HP:0009027)1.80189747
93Abnormality of the fovea (HP:0000493)1.76116093
94Increased connective tissue (HP:0009025)1.75900718
95Intestinal fistula (HP:0100819)1.75771730
96Cerebral hemorrhage (HP:0001342)1.75018575
97Atonic seizures (HP:0010819)1.74841065
98Generalized tonic-clonic seizures (HP:0002069)1.74426732
99Abnormality of the foot musculature (HP:0001436)1.73915179
100Vaginal fistula (HP:0004320)1.72952971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.19265882
2MKNK27.02930907
3PBK6.78791894
4MKNK14.97152566
5CSNK1G22.62736343
6CASK1.49294314
7PKN21.48229889
8EPHA41.38211153
9STK161.34049674
10EPHB11.32567077
11PRKD11.31596057
12MAP2K71.25931744
13CDK121.24633846
14MAPKAPK31.22382570
15SIK31.22257628
16CAMKK11.19224704
17SIK21.14038550
18PIK3CA1.06189273
19PRKCG1.04821088
20RIPK40.98362102
21RIPK10.96592123
22PAK60.94160870
23PTK60.90152646
24STK390.90091059
25PRKD30.86435692
26UHMK10.84592978
27DMPK0.84459150
28MARK20.84239802
29MAP2K40.83484893
30INSRR0.82924465
31CAMK2D0.81935774
32PAK30.79596591
33PLK20.78491652
34DYRK1A0.77082791
35SIK10.74640804
36FES0.74087881
37GRK70.71082625
38BTK0.70632250
39ROCK10.68864988
40RPS6KB20.68050377
41DYRK30.65915230
42CAMK2A0.63791743
43FER0.59573642
44MAPK120.57256198
45PRKCE0.57088040
46EPHB20.56758916
47PHKG10.55358361
48PHKG20.55358361
49MARK30.55216055
50MAPKAPK50.54821082
51BCR0.52549900
52MAP2K10.52428941
53PTK2B0.52329247
54EIF2AK20.52291836
55MAP3K40.51928739
56HCK0.50447400
57NTRK10.48368112
58PINK10.48283962
59TLK10.48202963
60CAMK2B0.47003881
61OXSR10.46962651
62MINK10.46786204
63OBSCN0.46539100
64PRKG10.45906859
65PRKACA0.45741178
66PAK20.45655437
67LIMK10.43575963
68CDK140.43384233
69ROCK20.43106590
70DYRK1B0.41308563
71CDK50.41250837
72WNK10.40697278
73ERN10.40538263
74TXK0.39338787
75ADRBK20.37958583
76PRKACB0.37090654
77GSK3A0.36926006
78MARK10.36108707
79PRKCB0.35769391
80STK240.34991651
81NTRK20.33868403
82MAP3K140.33866952
83MAPK40.33651184
84PRKCA0.33549697
85RAF10.31157307
86CDK150.30793489
87MAP3K60.30756802
88PRKD20.30344096
89MAPK130.29669356
90CSNK1A10.28050050
91NTRK30.27545239
92FYN0.27262341
93PKN10.26961462
94CDK180.26852659
95MAPK70.25918687
96ADRBK10.25874793
97MAPK100.25431632
98FGR0.25301213
99EGFR0.25228757
100MAPKAPK20.24390697

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.29101943
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.13504018
3Taste transduction_Homo sapiens_hsa047421.88258533
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83440016
5GABAergic synapse_Homo sapiens_hsa047271.74567873
6Salivary secretion_Homo sapiens_hsa049701.73629641
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71310752
8Circadian entrainment_Homo sapiens_hsa047131.70723209
9Glutamatergic synapse_Homo sapiens_hsa047241.68051802
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64261596
11Histidine metabolism_Homo sapiens_hsa003401.63154043
12Dilated cardiomyopathy_Homo sapiens_hsa054141.59312354
13Fatty acid elongation_Homo sapiens_hsa000621.57325862
14Morphine addiction_Homo sapiens_hsa050321.56450466
15Synaptic vesicle cycle_Homo sapiens_hsa047211.53660968
16Olfactory transduction_Homo sapiens_hsa047401.52128490
17Circadian rhythm_Homo sapiens_hsa047101.48308741
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45019006
19Axon guidance_Homo sapiens_hsa043601.41935694
20Cardiac muscle contraction_Homo sapiens_hsa042601.36984180
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.36255271
22Staphylococcus aureus infection_Homo sapiens_hsa051501.28405395
23Sulfur metabolism_Homo sapiens_hsa009201.27191083
24Renin secretion_Homo sapiens_hsa049241.23695457
25Complement and coagulation cascades_Homo sapiens_hsa046101.23445794
26ECM-receptor interaction_Homo sapiens_hsa045121.19846251
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18122978
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15833495
29Calcium signaling pathway_Homo sapiens_hsa040201.15442384
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15192937
31Serotonergic synapse_Homo sapiens_hsa047261.14682339
32Retinol metabolism_Homo sapiens_hsa008301.12872089
33Salmonella infection_Homo sapiens_hsa051321.11166057
34Propanoate metabolism_Homo sapiens_hsa006401.06910043
35Insulin secretion_Homo sapiens_hsa049111.05036108
36Amoebiasis_Homo sapiens_hsa051461.00372068
37Gap junction_Homo sapiens_hsa045401.00270912
38Alzheimers disease_Homo sapiens_hsa050100.97743753
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96130223
40Long-term potentiation_Homo sapiens_hsa047200.92195509
41Dopaminergic synapse_Homo sapiens_hsa047280.90620217
42Oxytocin signaling pathway_Homo sapiens_hsa049210.89950881
43Amphetamine addiction_Homo sapiens_hsa050310.89289973
44Sphingolipid signaling pathway_Homo sapiens_hsa040710.87724167
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87284499
46African trypanosomiasis_Homo sapiens_hsa051430.86260087
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84418586
48ErbB signaling pathway_Homo sapiens_hsa040120.83523160
49Oxidative phosphorylation_Homo sapiens_hsa001900.82717849
50Long-term depression_Homo sapiens_hsa047300.80930242
51Melanoma_Homo sapiens_hsa052180.80124246
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.79595660
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79441935
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.79397604
55Cholinergic synapse_Homo sapiens_hsa047250.78722120
56Rheumatoid arthritis_Homo sapiens_hsa053230.78382077
57Sphingolipid metabolism_Homo sapiens_hsa006000.77319120
58Chemical carcinogenesis_Homo sapiens_hsa052040.76961980
59Steroid biosynthesis_Homo sapiens_hsa001000.76391644
60Phagosome_Homo sapiens_hsa041450.75255216
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75099160
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74620026
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73819187
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73800796
65Phototransduction_Homo sapiens_hsa047440.73219283
66Ras signaling pathway_Homo sapiens_hsa040140.72940572
67Tyrosine metabolism_Homo sapiens_hsa003500.72404688
68Type II diabetes mellitus_Homo sapiens_hsa049300.72244412
69Selenocompound metabolism_Homo sapiens_hsa004500.72067546
70Choline metabolism in cancer_Homo sapiens_hsa052310.71125035
71Arginine and proline metabolism_Homo sapiens_hsa003300.70169204
72Glioma_Homo sapiens_hsa052140.68828225
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68192220
74VEGF signaling pathway_Homo sapiens_hsa043700.68140250
75Rap1 signaling pathway_Homo sapiens_hsa040150.67717601
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67539968
77Collecting duct acid secretion_Homo sapiens_hsa049660.67346877
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66922314
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66776447
80cAMP signaling pathway_Homo sapiens_hsa040240.64690280
81Gastric acid secretion_Homo sapiens_hsa049710.64390807
82Platelet activation_Homo sapiens_hsa046110.63847757
83* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63236361
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.62735647
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62100677
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61277219
87Vitamin digestion and absorption_Homo sapiens_hsa049770.58032963
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57867643
89Bile secretion_Homo sapiens_hsa049760.54141276
90Graft-versus-host disease_Homo sapiens_hsa053320.50912515
91Type I diabetes mellitus_Homo sapiens_hsa049400.50423857
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48550636
93Focal adhesion_Homo sapiens_hsa045100.47992099
94TNF signaling pathway_Homo sapiens_hsa046680.47054301
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46747383
96Butanoate metabolism_Homo sapiens_hsa006500.44855130
97* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44060298
98Mineral absorption_Homo sapiens_hsa049780.43876528
99* Tuberculosis_Homo sapiens_hsa051520.43191774
100Osteoclast differentiation_Homo sapiens_hsa043800.43133072

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