IFITM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.72913615
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.72913615
3leukocyte aggregation (GO:0070486)5.28529676
4oligosaccharide catabolic process (GO:0009313)4.91911409
5glycosphingolipid catabolic process (GO:0046479)4.38203759
6neuronal action potential propagation (GO:0019227)4.32674501
7regulation of isotype switching to IgG isotypes (GO:0048302)4.27624867
8barbed-end actin filament capping (GO:0051016)4.24742274
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22053296
10amino sugar catabolic process (GO:0046348)3.98951989
11virion attachment to host cell (GO:0019062)3.91763596
12adhesion of symbiont to host cell (GO:0044650)3.91763596
13synaptic vesicle exocytosis (GO:0016079)3.91388092
14keratan sulfate catabolic process (GO:0042340)3.90605323
15glycolipid catabolic process (GO:0019377)3.87588533
16adhesion of symbiont to host (GO:0044406)3.67261339
17cellular response to interleukin-15 (GO:0071350)3.65890649
18cellular response to thyroid hormone stimulus (GO:0097067)3.65191443
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.59078087
20adenosine receptor signaling pathway (GO:0001973)3.50169629
21response to peptidoglycan (GO:0032494)3.49656973
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.44557592
23regulation of synaptic vesicle exocytosis (GO:2000300)3.41138144
24glutamate secretion (GO:0014047)3.38274683
25regulation of mononuclear cell migration (GO:0071675)3.36868590
26negative regulation of type 2 immune response (GO:0002829)3.36758384
27ceramide catabolic process (GO:0046514)3.36048482
28synaptic vesicle maturation (GO:0016188)3.34267734
29neurotransmitter secretion (GO:0007269)3.33608757
30sequestering of actin monomers (GO:0042989)3.32897342
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32541037
32response to acidic pH (GO:0010447)3.31749553
33vocalization behavior (GO:0071625)3.28195284
34negative T cell selection (GO:0043383)3.23562055
35positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.22466116
36negative thymic T cell selection (GO:0045060)3.22104048
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17155817
38neuromuscular process controlling posture (GO:0050884)3.16871661
39protein localization to endosome (GO:0036010)3.16444755
40regulation of synaptic vesicle transport (GO:1902803)3.12443500
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08527318
42regulation of cholesterol storage (GO:0010885)3.06906041
43chondroitin sulfate catabolic process (GO:0030207)3.05158636
44regulation of B cell receptor signaling pathway (GO:0050855)3.05101657
45mannose metabolic process (GO:0006013)3.04906859
46positive regulation of extracellular matrix organization (GO:1903055)3.04663996
47membrane lipid catabolic process (GO:0046466)3.04038276
48T cell migration (GO:0072678)3.03611622
49cellular potassium ion homeostasis (GO:0030007)2.99511608
50positive thymic T cell selection (GO:0045059)2.99014734
51activation of MAPKKK activity (GO:0000185)2.97944382
52positive T cell selection (GO:0043368)2.95394404
53sphingolipid catabolic process (GO:0030149)2.94340960
54cellular response to arsenic-containing substance (GO:0071243)2.94039382
55regulation of membrane protein ectodomain proteolysis (GO:0051043)2.93605624
56response to thyroid hormone (GO:0097066)2.93300085
57lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90964559
58gamma-aminobutyric acid signaling pathway (GO:0007214)2.90430191
59negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89784886
60negative regulation of lymphocyte mediated immunity (GO:0002707)2.87635087
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.85500007
62response to interleukin-15 (GO:0070672)2.82227694
63regulation of extracellular matrix disassembly (GO:0010715)2.81787296
64synaptic vesicle docking involved in exocytosis (GO:0016081)2.80607758
65phagosome maturation (GO:0090382)2.79462759
66negative regulation of interleukin-12 production (GO:0032695)2.79137929
67negative regulation of erythrocyte differentiation (GO:0045647)2.77561235
68positive regulation of cholesterol efflux (GO:0010875)2.75330435
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74319952
70positive regulation of cellular amide metabolic process (GO:0034250)2.73081546
71response to manganese ion (GO:0010042)2.72370887
72positive regulation of chemokine biosynthetic process (GO:0045080)2.71464191
73transferrin transport (GO:0033572)2.70298985
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70113982
75regulation of natural killer cell mediated immunity (GO:0002715)2.70113982
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69947619
77regulation of apoptotic process involved in morphogenesis (GO:1902337)2.69307669
78neutrophil activation involved in immune response (GO:0002283)2.69170088
79leukocyte cell-cell adhesion (GO:0007159)2.68822958
80negative regulation of immunoglobulin mediated immune response (GO:0002890)2.67259302
81negative regulation of B cell mediated immunity (GO:0002713)2.67259302
82negative regulation of homotypic cell-cell adhesion (GO:0034111)2.67157584
83sodium ion export (GO:0071436)2.67008851
84regulation of T-helper 2 cell differentiation (GO:0045628)2.65808485
85glutamate receptor signaling pathway (GO:0007215)2.64914467
86glial cell migration (GO:0008347)2.64900956
87apoptotic cell clearance (GO:0043277)2.64564609
88macrophage activation involved in immune response (GO:0002281)2.64537002
89neurotransmitter transport (GO:0006836)2.64233704
90positive regulation of natural killer cell mediated immunity (GO:0002717)2.63678521
91positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.63678521
92detection of molecule of bacterial origin (GO:0032490)2.62635206
93positive regulation of leukocyte degranulation (GO:0043302)2.62433941
94regulation of synaptic transmission, dopaminergic (GO:0032225)2.60501333
95endothelial cell chemotaxis (GO:0035767)2.59976068
96positive regulation of astrocyte differentiation (GO:0048711)2.59795577
97neuron-neuron synaptic transmission (GO:0007270)2.59584672
98regulation of glutamate receptor signaling pathway (GO:1900449)2.58226073
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57603491
100gamma-aminobutyric acid transport (GO:0015812)2.57522523
101regulation of vitamin D biosynthetic process (GO:0060556)2.57178998
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57019198
103negative regulation of T cell mediated immunity (GO:0002710)2.56780167
104regulation of neurotransmitter secretion (GO:0046928)2.56396154
105N-acetylneuraminate metabolic process (GO:0006054)2.55866024
106regulation of early endosome to late endosome transport (GO:2000641)2.55702880
107synaptic transmission, glutamatergic (GO:0035249)2.55126456
108interferon-gamma production (GO:0032609)2.54876031
109membrane depolarization during action potential (GO:0086010)2.54874904
110positive regulation of neurotransmitter secretion (GO:0001956)2.54747974
111regulation of vesicle fusion (GO:0031338)2.54454114
112cerebellar Purkinje cell differentiation (GO:0021702)2.51966807
113regulation of extracellular matrix organization (GO:1903053)2.51747453
114decidualization (GO:0046697)2.50432537
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50196458
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.49498586
117long-term synaptic potentiation (GO:0060291)2.48936974
118regulation of isotype switching (GO:0045191)2.48825381
119ferric iron transport (GO:0015682)2.48272842
120trivalent inorganic cation transport (GO:0072512)2.48272842
121negative regulation of cation channel activity (GO:2001258)2.48041196
122long-term memory (GO:0007616)2.47877119
123positive regulation of vesicle fusion (GO:0031340)2.47590481
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46973115
125T-helper 1 type immune response (GO:0042088)2.46970480
126lysosome organization (GO:0007040)2.46441775
127lytic vacuole organization (GO:0080171)2.46441775
128response to magnesium ion (GO:0032026)2.46418991
129locomotory exploration behavior (GO:0035641)2.46121819
130regulation of neurotransmitter transport (GO:0051588)2.45283603
131positive regulation of heat generation (GO:0031652)2.45141425
132regulation of leukocyte degranulation (GO:0043300)2.45050104
133regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.44333930
134B cell proliferation (GO:0042100)2.43939139
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.42862272
136positive regulation of p38MAPK cascade (GO:1900745)2.41750945
137stress fiber assembly (GO:0043149)2.40970853
138ganglioside metabolic process (GO:0001573)2.39407609
139semaphorin-plexin signaling pathway (GO:0071526)2.38984881
140catecholamine transport (GO:0051937)2.38846238
141myeloid dendritic cell differentiation (GO:0043011)2.37922469
142negative regulation of dendrite morphogenesis (GO:0050774)2.37822821
143positive regulation of DNA recombination (GO:0045911)2.36576887
144synaptic vesicle endocytosis (GO:0048488)2.36037306
145positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36008568
146negative regulation of cytokine production involved in immune response (GO:0002719)2.35651941
147regulation of voltage-gated calcium channel activity (GO:1901385)2.35181511
148positive regulation of protein dephosphorylation (GO:0035307)2.34434117
149regulation of neurotransmitter levels (GO:0001505)2.34346347
150regulation of leukocyte mediated cytotoxicity (GO:0001910)2.34247871
151positive regulation of mast cell activation (GO:0033005)2.34105073
152regulation of macrophage chemotaxis (GO:0010758)2.34048977
153thymic T cell selection (GO:0045061)2.33817182
154negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.32980225
155regulation of mast cell degranulation (GO:0043304)2.32728249
156cell-cell junction maintenance (GO:0045217)2.32621154
157positive regulation of gamma-delta T cell activation (GO:0046645)2.32496126
158regulation of podosome assembly (GO:0071801)2.32201548
159regulation of chemokine biosynthetic process (GO:0045073)2.31768428
160endocytic recycling (GO:0032456)2.31681173
161positive regulation of mast cell degranulation (GO:0043306)2.30995878
162positive regulation of mast cell activation involved in immune response (GO:0033008)2.30995878
163amyloid precursor protein catabolic process (GO:0042987)2.30957880
164dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30319061
165positive regulation of lamellipodium assembly (GO:0010592)2.30304116
166response to progesterone (GO:0032570)2.30188205
167low-density lipoprotein particle clearance (GO:0034383)2.30079999
168proline transport (GO:0015824)2.29739253
169behavioral response to pain (GO:0048266)2.28852514
170protein localization to synapse (GO:0035418)2.28807857
171positive regulation of isotype switching (GO:0045830)2.28267394
172neuron cell-cell adhesion (GO:0007158)2.28170032
173hyaluronan catabolic process (GO:0030214)2.28030251
174monocyte chemotaxis (GO:0002548)2.27907314
175epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27524705
176response to muramyl dipeptide (GO:0032495)2.25223243
177modulation by symbiont of host cellular process (GO:0044068)2.24585234
178positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.24396519
179regulation of type 2 immune response (GO:0002828)2.24298839
180negative regulation of lipid storage (GO:0010888)2.23652622
181negative regulation of leukocyte mediated immunity (GO:0002704)2.22385228
182exploration behavior (GO:0035640)2.22008017
183positive regulation of receptor recycling (GO:0001921)2.21929844
184establishment of synaptic vesicle localization (GO:0097480)2.21844615
185synaptic vesicle transport (GO:0048489)2.21844615
186regulation of immunoglobulin mediated immune response (GO:0002889)2.21629629
187G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.20964654
188embryo implantation (GO:0007566)2.20918302
189regulation of nitric oxide biosynthetic process (GO:0045428)2.17828548
190NIK/NF-kappaB signaling (GO:0038061)2.17707306
191regulation of superoxide anion generation (GO:0032928)2.17514255
192negative regulation of granulocyte differentiation (GO:0030853)2.16512133
193regulation of myeloid leukocyte mediated immunity (GO:0002886)2.16341993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human3.71233563
2EZH2_22144423_ChIP-Seq_EOC_Human3.22482564
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.14207309
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.06234386
5GBX2_23144817_ChIP-Seq_PC3_Human3.00199510
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.93805672
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.91875153
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.89943368
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77621043
10LXR_22292898_ChIP-Seq_THP-1_Human2.73761307
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.67015163
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48587590
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43446283
14AR_21572438_ChIP-Seq_LNCaP_Human2.34985379
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33952697
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32062273
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30612614
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.23850897
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23665598
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.22191914
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16302221
22VDR_21846776_ChIP-Seq_THP-1_Human2.15493305
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03102215
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02141405
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99888833
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98215516
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98215516
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96949813
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96517846
30RACK7_27058665_Chip-Seq_MCF-7_Human1.94893813
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91400538
32RUNX_20019798_ChIP-Seq_JUKART_Human1.91312151
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91147632
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91124135
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89943664
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.88733945
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86201495
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.84608368
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84034457
40KDM2B_26808549_Chip-Seq_K562_Human1.81388370
41REST_21632747_ChIP-Seq_MESCs_Mouse1.79807075
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79410460
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78962321
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77551427
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.77356978
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.74689845
47DROSHA_22980978_ChIP-Seq_HELA_Human1.74147218
48TAF15_26573619_Chip-Seq_HEK293_Human1.74077045
49KDM2B_26808549_Chip-Seq_DND41_Human1.73166527
50VDR_24763502_ChIP-Seq_THP-1_Human1.72285703
51SMAD4_21799915_ChIP-Seq_A2780_Human1.68827425
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67024258
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66174683
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64267728
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.64236158
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63337407
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.62541468
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61594256
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60797554
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60476304
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59327063
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56682371
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56228173
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56112886
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.55231634
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54457514
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53657161
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50587782
69P300_19829295_ChIP-Seq_ESCs_Human1.49987991
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48848306
71TCF7_22412390_ChIP-Seq_EML_Mouse1.47092780
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.46462759
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.45763965
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44819287
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40483504
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40372540
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36783246
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.36312080
79P68_20966046_ChIP-Seq_HELA_Human1.36238933
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35235102
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32781323
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31537227
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30598427
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30370428
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.29218160
86SMC4_20622854_ChIP-Seq_HELA_Human1.29188064
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.28299518
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28026632
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27740409
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.27227568
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26897103
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25929338
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.25905845
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25885995
95CLOCK_20551151_ChIP-Seq_293T_Human1.24892659
96BCOR_27268052_Chip-Seq_Bcells_Human1.24185156
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23543501
98ZNF263_19887448_ChIP-Seq_K562_Human1.23206584
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23164543
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23056620
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22648733
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.22267175
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21739790
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20404114
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.19851929
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19812753
107SPI1_23127762_ChIP-Seq_K562_Human1.18989188
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.18927097
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18902667
110BCL6_27268052_Chip-Seq_Bcells_Human1.18642669
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18431107
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18290375
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.15960955
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15935940
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15638316
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.14755553
117AR_25329375_ChIP-Seq_VCAP_Human1.14600934
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13953715
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13774773
120RXR_22158963_ChIP-Seq_LIVER_Mouse1.13774273
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12179982
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.11931957
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11736072
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.10901257
125TP53_18474530_ChIP-ChIP_U2OS_Human1.10870160
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09660588
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.08538672
128SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07625043
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.06497674
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06370420
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06278028
132RUNX1_22412390_ChIP-Seq_EML_Mouse1.06091216
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06061685
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05636942
135CTCF_27219007_Chip-Seq_Bcells_Human1.05294441
136MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04940795
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04855915
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04722897
139P53_22387025_ChIP-Seq_ESCs_Mouse1.04020651
140NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03632945
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03447725
142PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02144301
143STAT3_23295773_ChIP-Seq_U87_Human1.01901891
144CREB1_26743006_Chip-Seq_LNCaP_Human1.01562459
145GATA1_19941826_ChIP-Seq_K562_Human1.00714080
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00579663
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00579532
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00457437
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00377129
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00292566
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00032654
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99998253
153P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99555484
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99290838
155NFE2_27457419_Chip-Seq_LIVER_Mouse0.99177085
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98995797
157PRDM14_20953172_ChIP-Seq_ESCs_Human0.98932964
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97510437
159TP53_22127205_ChIP-Seq_IMR90_Human0.97453305
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.97254249
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97051747
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96822466
163LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96689272
164SA1_27219007_Chip-Seq_Bcells_Human0.96189543
165NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95898296
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95535452
167TCF4_22108803_ChIP-Seq_LS180_Human0.95236654
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.95091369
169JUN_21703547_ChIP-Seq_K562_Human0.94806202
170CBX2_27304074_Chip-Seq_ESCs_Mouse0.94036919
171OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93901145
172RUNX2_22187159_ChIP-Seq_PCA_Human0.93422963
173CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93065615
174VDR_24787735_ChIP-Seq_THP-1_Human0.92876070
175TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92307523
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.92157304
177EZH2_27294783_Chip-Seq_NPCs_Mouse0.90856180
178PU1_27457419_Chip-Seq_LIVER_Mouse0.90703234
179UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90466479
180SOX2_21211035_ChIP-Seq_LN229_Gbm0.89815170
181SOX2_18555785_Chip-Seq_ESCs_Mouse0.89623791
182EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89442401
183IGF1R_20145208_ChIP-Seq_DFB_Human0.88700276
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87803955
185ER_23166858_ChIP-Seq_MCF-7_Human0.87598343
186P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86559151
187RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85232599
188MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84443828
189P300_18555785_Chip-Seq_ESCs_Mouse0.84364168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.58402355
2MP0009840_abnormal_foam_cell3.84203496
3MP0003880_abnormal_central_pattern3.56294114
4MP0004859_abnormal_synaptic_plasticity3.55719012
5MP0009046_muscle_twitch3.37244252
6MP0002735_abnormal_chemical_nociception3.09842150
7MP0003303_peritoneal_inflammation2.94008238
8MP0003191_abnormal_cellular_cholesterol2.79357252
9MP0006082_CNS_inflammation2.78526378
10MP0003635_abnormal_synaptic_transmissio2.72722672
11MP0005671_abnormal_response_to2.70484159
12MP0002064_seizures2.68068663
13MP0002736_abnormal_nociception_after2.64672381
14MP0009745_abnormal_behavioral_response2.62612332
15MP0000604_amyloidosis2.60594377
16MP0001968_abnormal_touch/_nociception2.60380761
17MP0009785_altered_susceptibility_to2.46802924
18MP0001501_abnormal_sleep_pattern2.44018540
19MP0002139_abnormal_hepatobiliary_system2.41790822
20MP0000343_altered_response_to2.29991729
21MP0003724_increased_susceptibility_to2.15594554
22MP0002933_joint_inflammation2.13169229
23MP0004510_myositis2.06510603
24MP0003705_abnormal_hypodermis_morpholog2.04306049
25MP0002272_abnormal_nervous_system2.03536601
26MP0002063_abnormal_learning/memory/cond2.03138913
27MP0002909_abnormal_adrenal_gland2.01132070
28MP0003453_abnormal_keratinocyte_physiol1.99853892
29MP0001188_hyperpigmentation1.94193672
30MP0006276_abnormal_autonomic_nervous1.93854682
31MP0001835_abnormal_antigen_presentation1.91746509
32MP0002734_abnormal_mechanical_nocicepti1.88303557
33MP0002572_abnormal_emotion/affect_behav1.87451514
34MP0003690_abnormal_glial_cell1.81418815
35MP0009278_abnormal_bone_marrow1.77155743
36MP0003279_aneurysm1.76846016
37MP0002067_abnormal_sensory_capabilities1.76040186
38MP0008569_lethality_at_weaning1.74432775
39MP0001970_abnormal_pain_threshold1.68240525
40MP0008260_abnormal_autophagy1.66777260
41MP0005387_immune_system_phenotype1.66454066
42MP0001790_abnormal_immune_system1.66454066
43MP0001853_heart_inflammation1.65935155
44MP0003806_abnormal_nucleotide_metabolis1.65749917
45MP0000920_abnormal_myelination1.64440204
46MP0002254_reproductive_system_inflammat1.62078788
47MP0003787_abnormal_imprinting1.60831834
48MP0005646_abnormal_pituitary_gland1.57058432
49MP0003300_gastrointestinal_ulcer1.54596021
50MP0000685_abnormal_immune_system1.53625416
51MP0002184_abnormal_innervation1.50776438
52MP0003646_muscle_fatigue1.49528003
53MP0001486_abnormal_startle_reflex1.46487333
54MP0003122_maternal_imprinting1.46460417
55MP0008438_abnormal_cutaneous_collagen1.46413271
56MP0004142_abnormal_muscle_tone1.45714517
57MP0002733_abnormal_thermal_nociception1.43104451
58MP0002822_catalepsy1.42297886
59MP0003634_abnormal_glial_cell1.39459307
60MP0005451_abnormal_body_composition1.37773804
61MP0005165_increased_susceptibility_to1.36835884
62MP0005166_decreased_susceptibility_to1.34593616
63MP0003329_amyloid_beta_deposits1.34314704
64MP0005000_abnormal_immune_tolerance1.31375648
65MP0001533_abnormal_skeleton_physiology1.30665843
66MP0003763_abnormal_thymus_physiology1.29780012
67MP0005257_abnormal_intraocular_pressure1.29288064
68MP0004947_skin_inflammation1.28077067
69MP0010386_abnormal_urinary_bladder1.27807854
70MP0002148_abnormal_hypersensitivity_rea1.26758709
71MP0001984_abnormal_olfaction1.25444067
72MP0005025_abnormal_response_to1.25301386
73MP0001905_abnormal_dopamine_level1.24670791
74MP0005023_abnormal_wound_healing1.21146855
75MP0002419_abnormal_innate_immunity1.20875043
76MP0003045_fibrosis1.16887475
77MP0002998_abnormal_bone_remodeling1.15261435
78MP0004270_analgesia1.14977499
79MP0005595_abnormal_vascular_smooth1.13094238
80MP0003183_abnormal_peptide_metabolism1.12781191
81MP0002723_abnormal_immune_serum1.12643411
82MP0002420_abnormal_adaptive_immunity1.12187195
83MP0001819_abnormal_immune_cell1.11878082
84MP0004858_abnormal_nervous_system1.10709103
85MP0003633_abnormal_nervous_system1.09999719
86MP0002405_respiratory_system_inflammati1.09990668
87MP0001502_abnormal_circadian_rhythm1.09264186
88MP0002876_abnormal_thyroid_physiology1.09132434
89MP0005397_hematopoietic_system_phenotyp1.08954163
90MP0001545_abnormal_hematopoietic_system1.08954163
91MP0001440_abnormal_grooming_behavior1.08775430
92MP0004484_altered_response_of1.08205019
93MP0009764_decreased_sensitivity_to1.07933926
94MP0003436_decreased_susceptibility_to1.07832361
95MP0003879_abnormal_hair_cell1.07511292
96MP0002557_abnormal_social/conspecific_i1.06469304
97MP0003091_abnormal_cell_migration1.06148851
98MP0000747_muscle_weakness1.04043134
99MP0008874_decreased_physiological_sensi1.02052572
100MP0004134_abnormal_chest_morphology1.01891877
101MP0003656_abnormal_erythrocyte_physiolo1.01400871
102MP0002896_abnormal_bone_mineralization0.97898496
103MP0008469_abnormal_protein_level0.96699474
104MP0005464_abnormal_platelet_physiology0.95441586
105MP0005076_abnormal_cell_differentiation0.95234519
106MP0001800_abnormal_humoral_immune0.94869532
107MP0005386_behavior/neurological_phenoty0.94855366
108MP0004924_abnormal_behavior0.94855366
109MP0002877_abnormal_melanocyte_morpholog0.94252465
110MP0001958_emphysema0.94178064
111MP0001542_abnormal_bone_strength0.93550302
112MP0002332_abnormal_exercise_endurance0.93348147
113MP0001845_abnormal_inflammatory_respons0.92489582
114MP0004811_abnormal_neuron_physiology0.92014519
115MP0002452_abnormal_antigen_presenting0.91951388
116MP0000858_altered_metastatic_potential0.91665891
117MP0005645_abnormal_hypothalamus_physiol0.91512788
118MP0006054_spinal_hemorrhage0.90770330
119MP0005164_abnormal_response_to0.89921772
120MP0001299_abnormal_eye_distance/0.89425356
121MP0009780_abnormal_chondrocyte_physiolo0.89180059
122MP0000751_myopathy0.88279181
123MP0008872_abnormal_physiological_respon0.88227964
124MP0001851_eye_inflammation0.87957170
125MP0003828_pulmonary_edema0.87616497
126MP0005508_abnormal_skeleton_morphology0.86915637
127MP0005503_abnormal_tendon_morphology0.86547769
128MP0000767_abnormal_smooth_muscle0.85889210
129MP0005365_abnormal_bile_salt0.84861032
130MP0003172_abnormal_lysosome_physiology0.84371436
131MP0002090_abnormal_vision0.83194657
132MP0003566_abnormal_cell_adhesion0.83111407
133MP0005310_abnormal_salivary_gland0.82888906
134MP0001963_abnormal_hearing_physiology0.81797554
135MP0002163_abnormal_gland_morphology0.81093172
136MP0003448_altered_tumor_morphology0.80214027
137MP0003795_abnormal_bone_structure0.79822500
138MP0000249_abnormal_blood_vessel0.76971820
139MP0002066_abnormal_motor_capabilities/c0.76734591
140MP0000750_abnormal_muscle_regeneration0.76433579
141MP0002295_abnormal_pulmonary_circulatio0.76145240
142MP0004019_abnormal_vitamin_homeostasis0.75770784
143MP0000749_muscle_degeneration0.74727400
144MP0005390_skeleton_phenotype0.74473470
145MP0005167_abnormal_blood-brain_barrier0.74335648
146MP0005551_abnormal_eye_electrophysiolog0.73115701
147MP0008004_abnormal_stomach_pH0.72916793
148MP0003075_altered_response_to0.72047825
149MP0005423_abnormal_somatic_nervous0.71838996
150MP0001849_ear_inflammation0.70527465
151MP0004742_abnormal_vestibular_system0.70513175
152MP0000681_abnormal_thyroid_gland0.69373718
153MP0003631_nervous_system_phenotype0.67945068
154MP0002282_abnormal_trachea_morphology0.67378150
155MP0000955_abnormal_spinal_cord0.66887294
156MP0005275_abnormal_skin_tensile0.66490309
157MP0010155_abnormal_intestine_physiology0.66081456
158MP0002060_abnormal_skin_morphology0.65739361
159MP0009384_cardiac_valve_regurgitation0.65116061
160MP0004883_abnormal_blood_vessel0.64843232

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.53444321
2Abnormality of liposaccharide metabolism (HP:0010968)7.53444321
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.53444321
4Irregular epiphyses (HP:0010582)6.18606342
5Epiphyseal dysplasia (HP:0002656)5.82161787
6Focal motor seizures (HP:0011153)5.67223389
7Increased cerebral lipofuscin (HP:0011813)5.37597297
8Increased IgM level (HP:0003496)5.32415165
9Febrile seizures (HP:0002373)5.21550289
10Systemic lupus erythematosus (HP:0002725)5.19814261
11Dysostosis multiplex (HP:0000943)5.02287357
12Vitreoretinal degeneration (HP:0000655)4.79142378
13Vacuolated lymphocytes (HP:0001922)4.69378040
14Increased neuronal autofluorescent lipopigment (HP:0002074)4.59633998
15Stomatitis (HP:0010280)4.54174329
16Neurofibrillary tangles (HP:0002185)4.46785116
17Atonic seizures (HP:0010819)4.35717313
18Axonal loss (HP:0003447)4.35018980
19Nuclear cataract (HP:0100018)4.14139422
20Loss of speech (HP:0002371)4.09871445
21Mutism (HP:0002300)3.89910641
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.88324377
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.88324377
24Abnormality of polysaccharide metabolism (HP:0011012)3.88324377
25Disinhibition (HP:0000734)3.87473041
26Small epiphyses (HP:0010585)3.80385396
27Urinary glycosaminoglycan excretion (HP:0003541)3.74687896
28Mucopolysacchariduria (HP:0008155)3.74687896
29Myokymia (HP:0002411)3.67299651
30Glomerulonephritis (HP:0000099)3.62262698
31Eczematoid dermatitis (HP:0000976)3.60272795
32Complement deficiency (HP:0004431)3.49387326
33Progressive cerebellar ataxia (HP:0002073)3.47238479
34Flat capital femoral epiphysis (HP:0003370)3.42748395
35Supranuclear gaze palsy (HP:0000605)3.37173815
36Epileptic encephalopathy (HP:0200134)3.35957362
37Cerebral inclusion bodies (HP:0100314)3.27672455
38Focal seizures (HP:0007359)3.24858008
39Abnormal tarsal ossification (HP:0008369)3.24134775
40Severe combined immunodeficiency (HP:0004430)3.22904060
41Neuronal loss in central nervous system (HP:0002529)3.18520337
42Apathy (HP:0000741)3.12158871
43Short femoral neck (HP:0100864)3.05883134
44Absence seizures (HP:0002121)3.05614673
45Cupped ribs (HP:0000887)3.01931206
46Diminished motivation (HP:0000745)3.00727269
47Abnormality of the vertebral endplates (HP:0005106)3.00473605
48Vertebral compression fractures (HP:0002953)3.00082237
49Abnormality of macrophages (HP:0004311)2.96029781
50Abnormality of complement system (HP:0005339)2.95581279
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.93839925
52Abnormality of femoral epiphyses (HP:0006499)2.89647539
53Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.89647539
54J-shaped sella turcica (HP:0002680)2.87541190
55Genu varum (HP:0002970)2.86025454
56Abnormality of T cell number (HP:0011839)2.83674982
57Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.80450713
58T lymphocytopenia (HP:0005403)2.79578313
59Gingivitis (HP:0000230)2.73482215
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.72213998
61Irregular vertebral endplates (HP:0003301)2.70932536
62Amyloidosis (HP:0011034)2.68281146
63Joint stiffness (HP:0001387)2.67669641
64Metaphyseal irregularity (HP:0003025)2.67404030
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65978450
66Flat acetabular roof (HP:0003180)2.63712593
67Abnormality of the femoral head (HP:0003368)2.62029793
68Generalized tonic-clonic seizures (HP:0002069)2.58415619
69Progressive inability to walk (HP:0002505)2.58041847
70Hypoplastic ischia (HP:0003175)2.55677107
71Absent epiphyses (HP:0010577)2.55633390
72Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.55633390
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.52865348
74Retinal atrophy (HP:0001105)2.52796025
75Arthropathy (HP:0003040)2.50960303
76Combined immunodeficiency (HP:0005387)2.50789278
77Flattened epiphyses (HP:0003071)2.48240877
78Purpura (HP:0000979)2.47786240
79Action tremor (HP:0002345)2.47382996
80Visual hallucinations (HP:0002367)2.46989620
81Obstructive sleep apnea (HP:0002870)2.46516867
82Aplasia/hypoplasia of the femur (HP:0005613)2.46311705
83Dialeptic seizures (HP:0011146)2.45700189
84Abnormality of the vasculature of the conjunctiva (HP:0008054)2.44691510
85Dementia (HP:0000726)2.43918949
86Diplopia (HP:0000651)2.42420686
87Abnormality of binocular vision (HP:0011514)2.42420686
88Osteoarthritis (HP:0002758)2.41667014
89Recurrent abscess formation (HP:0002722)2.39510101
90Mild short stature (HP:0003502)2.36997993
91Delayed epiphyseal ossification (HP:0002663)2.36395085
92Prolonged neonatal jaundice (HP:0006579)2.33908945
93Abnormal hair whorl (HP:0010721)2.33872895
94Abnormality of the ischium (HP:0003174)2.33329228
95Progressive neurologic deterioration (HP:0002344)2.33058461
96Distal lower limb muscle weakness (HP:0009053)2.32592847
97Thyroiditis (HP:0100646)2.28997489
98Fetal akinesia sequence (HP:0001989)2.28484862
99Abnormal foot bone ossification (HP:0010675)2.28067919
100IgG deficiency (HP:0004315)2.27965873
101Cerebral aneurysm (HP:0004944)2.26953506
102Upper motor neuron abnormality (HP:0002127)2.23896441
103Hemiplegia (HP:0002301)2.22490982
104Barrel-shaped chest (HP:0001552)2.22191094
105Hypothermia (HP:0002045)2.21055380
106Mediastinal lymphadenopathy (HP:0100721)2.20873315
107Retrobulbar optic neuritis (HP:0100654)2.15319447
108Optic neuritis (HP:0100653)2.15319447
109Pathologic fracture (HP:0002756)2.14728190
110Abnormality of incisor morphology (HP:0011063)2.14408683
111Cervical subluxation (HP:0003308)2.13590326
112Increased serum ferritin (HP:0003281)2.09477256
113Neonatal short-limb short stature (HP:0008921)2.08456552
114Upper limb amyotrophy (HP:0009129)2.08019324
115Distal upper limb amyotrophy (HP:0007149)2.08019324
116Joint swelling (HP:0001386)2.07629912
117Gaze-evoked nystagmus (HP:0000640)2.06576925
118Inappropriate behavior (HP:0000719)2.04469848
119Myocardial infarction (HP:0001658)2.02845459
120Nephritis (HP:0000123)2.01800461
121Spinal canal stenosis (HP:0003416)2.01792744
122Spondylolisthesis (HP:0003302)2.01063398
123Interstitial pulmonary disease (HP:0006530)2.01023030
124Personality changes (HP:0000751)1.99705758
125Cardiomegaly (HP:0001640)1.99619359
126Recurrent bacterial skin infections (HP:0005406)1.97464924
127Congenital stationary night blindness (HP:0007642)1.95081213
128Disproportionate short-trunk short stature (HP:0003521)1.94748205
129Failure to thrive in infancy (HP:0001531)1.94720811
130Asymmetric septal hypertrophy (HP:0001670)1.91938821
131Bone pain (HP:0002653)1.88823870
132Recurrent gram-negative bacterial infections (HP:0005420)1.88801967
133Neuroendocrine neoplasm (HP:0100634)1.88633054
134Hypergammaglobulinemia (HP:0010702)1.87672744
135Bulbar palsy (HP:0001283)1.84981442
136Chronic mucocutaneous candidiasis (HP:0002728)1.84201174
137Recurrent cutaneous fungal infections (HP:0011370)1.84201174
138Achilles tendon contracture (HP:0001771)1.84164490
139Hepatosplenomegaly (HP:0001433)1.81767903
140Waddling gait (HP:0002515)1.79568768
141Autoimmune thrombocytopenia (HP:0001973)1.78678297
142Recurrent fungal infections (HP:0002841)1.78159966
143Ovoid vertebral bodies (HP:0003300)1.77440558
144Esotropia (HP:0000565)1.75635473
145Abnormality of the nasal mucosa (HP:0000433)1.75608981
146Hand muscle atrophy (HP:0009130)1.75234355
147Hypoplasia of the odontoid process (HP:0003311)1.74003348
148Spinal cord compression (HP:0002176)1.73799203
149Scanning speech (HP:0002168)1.73399116
150Polygenic inheritance (HP:0010982)1.72287993
151Urinary incontinence (HP:0000020)1.71894800
152Rigidity (HP:0002063)1.71403305
153Severe Myopia (HP:0011003)1.71365564
154Obstructive lung disease (HP:0006536)1.70934856
155Chronic obstructive pulmonary disease (HP:0006510)1.70934856
156Agnosia (HP:0010524)1.70492680
157Patent foramen ovale (HP:0001655)1.69838666
158Bradycardia (HP:0001662)1.68528942
159Inability to walk (HP:0002540)1.68033181
160Thin bony cortex (HP:0002753)1.67697325
161Abnormal eating behavior (HP:0100738)1.66884308
162Deformed sella turcica (HP:0002681)1.66069080
163Lumbar hyperlordosis (HP:0002938)1.66064592
164Orchitis (HP:0100796)1.65575902
165Beaking of vertebral bodies (HP:0004568)1.65482059
166Global brain atrophy (HP:0002283)1.64400236
167Hyperparathyroidism (HP:0000843)1.63898297
168Abnormality of the Achilles tendon (HP:0005109)1.63603601
169Peripheral demyelination (HP:0011096)1.63409900
170Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63159453
171Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63122186
172Premature rupture of membranes (HP:0001788)1.62022885
173Radial bowing (HP:0002986)1.61890467
174Rapidly progressive (HP:0003678)1.61089525
175Thoracic kyphosis (HP:0002942)1.60849245
176Abnormality of T cells (HP:0002843)1.60325934
177Zonular cataract (HP:0010920)1.60167876
178Menstrual irregularities (HP:0000858)1.59569845
179Basal ganglia calcification (HP:0002135)1.59269404
180Protrusio acetabuli (HP:0003179)1.58410979
181Abnormality of the pubic bones (HP:0003172)1.57975722
182Fibular hypoplasia (HP:0003038)1.57614134
183Ventricular fibrillation (HP:0001663)1.56733694
184Abnormality of the periventricular white matter (HP:0002518)1.56571293
185Short nail (HP:0001799)1.56056664
186Memory impairment (HP:0002354)1.52514759
187Mitral stenosis (HP:0001718)1.51292467
188Bone cyst (HP:0012062)1.50391287
189Hyperacusis (HP:0010780)1.50385584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K126.41892441
2TXK3.79430713
3NME23.62804595
4IRAK33.52464035
5NTRK33.17974700
6SIK12.78065768
7RIPK12.75461485
8CASK2.60728574
9ERN12.58433295
10SIK32.56163200
11MAP2K72.44302743
12TAOK22.35029402
13RIPK42.34818857
14TRIB32.03163620
15GRK71.94131286
16TAOK11.89993567
17PIM21.87450087
18ABL21.86242278
19MINK11.86064490
20MAP3K141.79384940
21MYLK1.76287392
22JAK11.73142363
23TNK21.57957308
24IKBKE1.53961205
25PLK21.50654770
26MAP3K41.47557316
27ADRBK21.46566055
28DAPK21.42974386
29STK241.42289790
30MAP3K91.41253170
31MAP2K31.40260215
32LATS21.36203062
33PRKCH1.35250623
34CDC42BPA1.33782380
35MAP2K41.31202700
36PRKG21.30134879
37MOS1.29052868
38BLK1.27243091
39SGK21.25169946
40STK38L1.24675612
41GRK51.22491154
42BMPR21.19764888
43MST41.19199770
44ZAP701.18923370
45STK381.18053571
46TBK11.15465893
47PRKD21.15173264
48LIMK11.13850722
49MARK21.13447272
50MAPKAPK31.11741106
51ICK1.09349429
52PDGFRA1.08865519
53IKBKB1.06171992
54EPHB21.04501132
55PAK41.04221177
56ITK1.01271316
57NEK91.00862670
58NME10.99330231
59ARAF0.99048247
60NEK60.96673045
61MAPK150.96514050
62TESK10.93858980
63PDK20.93481050
64CAMKK20.91644161
65EPHA20.91222945
66DAPK10.91209197
67PRPF4B0.90954634
68MAP3K130.88980407
69CAMKK10.87993800
70MAP3K30.87706175
71CHUK0.86428638
72IRAK20.86402673
73WNK10.84149340
74PRKCG0.83547494
75MAP2K60.83425684
76RPS6KA20.83323388
77AKT30.83095326
78SGK30.82780703
79MATK0.82349835
80SGK4940.81799469
81SGK2230.81799469
82FGR0.81745018
83BMX0.80884142
84JAK30.79883327
85IRAK40.79368150
86CSK0.77885430
87MAP3K110.77621069
88CAMK1D0.76684060
89NTRK10.73096508
90MAPK120.72046127
91CDK30.71985658
92TYK20.70063600
93MAPK70.68995156
94CAMK2A0.68191356
95SIK20.67959740
96MST1R0.67427211
97HIPK20.66933409
98PDPK10.66718507
99BCR0.66592047
100PINK10.66565713
101PRKCE0.66407308
102NTRK20.66393604
103LCK0.66132920
104PRKD30.65890178
105MAPK130.64860742
106CAMK2B0.63783091
107PTK20.63449438
108MAP4K10.60938215
109YES10.60887118
110LMTK20.60312795
111TEC0.60196117
112EPHA40.59617516
113PRKCQ0.59073816
114TGFBR20.59012917
115DMPK0.57145337
116PAK60.57057155
117CDK50.56513901
118MAP3K60.55656759
119MAPK40.55498203
120CAMK2G0.54775858
121TTN0.54664351
122FES0.54085303
123ZAK0.52623986
124MUSK0.51452872
125RPS6KC10.50019037
126RPS6KL10.50019037
127ROCK10.49643730
128SGK10.48874805
129KDR0.48849470
130ERBB30.48090550
131PKN10.48007189
132SYK0.47977405
133PHKG20.47839120
134PHKG10.47839120
135PTK2B0.47218469
136DDR20.46412013
137DYRK1A0.46182225
138FYN0.46096243
139CAMK10.45090402
140PRKCD0.44915446
141CSF1R0.44838391
142PKN20.44579711
143CDK190.44496902
144DAPK30.43745405
145MAPKAPK20.42704148
146TESK20.42656163
147PDGFRB0.41994843
148TNIK0.41488817
149CDK150.41390634
150NLK0.41060899
151CDK11A0.40858568
152MAP3K50.40701782
153CAMK2D0.40424881
154TYRO30.39787727
155ERBB40.39001500
156CDK80.38627099
157SMG10.38502482
158PRKD10.37610339
159OBSCN0.37489339
160MTOR0.37127445
161MAP3K10.36930806
162CDK180.36335896
163PRKCA0.36235938

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.22104003
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.13624607
3Synaptic vesicle cycle_Homo sapiens_hsa047213.12668937
4Graft-versus-host disease_Homo sapiens_hsa053322.83027907
5Allograft rejection_Homo sapiens_hsa053302.29383388
6Primary immunodeficiency_Homo sapiens_hsa053402.20373349
7Collecting duct acid secretion_Homo sapiens_hsa049662.17245724
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14755758
9Olfactory transduction_Homo sapiens_hsa047402.10548948
10Prion diseases_Homo sapiens_hsa050202.02123698
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97517825
12Morphine addiction_Homo sapiens_hsa050321.92402538
13Rheumatoid arthritis_Homo sapiens_hsa053231.89984421
14GABAergic synapse_Homo sapiens_hsa047271.85328766
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80012044
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73502242
17Circadian entrainment_Homo sapiens_hsa047131.73392679
18Autoimmune thyroid disease_Homo sapiens_hsa053201.57494733
19Type I diabetes mellitus_Homo sapiens_hsa049401.56958930
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52360520
21Amphetamine addiction_Homo sapiens_hsa050311.50650875
22Glutamatergic synapse_Homo sapiens_hsa047241.49048248
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47443751
24Salivary secretion_Homo sapiens_hsa049701.45723461
25Complement and coagulation cascades_Homo sapiens_hsa046101.41262647
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.38209183
27Malaria_Homo sapiens_hsa051441.37648194
28Asthma_Homo sapiens_hsa053101.32512323
29Long-term potentiation_Homo sapiens_hsa047201.31690880
30Taste transduction_Homo sapiens_hsa047421.30506918
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29310141
32Vibrio cholerae infection_Homo sapiens_hsa051101.27889908
33Sphingolipid metabolism_Homo sapiens_hsa006001.27803161
34Dopaminergic synapse_Homo sapiens_hsa047281.26791983
35Calcium signaling pathway_Homo sapiens_hsa040201.23274887
36Serotonergic synapse_Homo sapiens_hsa047261.22032085
37Oxidative phosphorylation_Homo sapiens_hsa001901.19545343
38Insulin secretion_Homo sapiens_hsa049111.17923082
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17881478
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17416335
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17331289
42Cholinergic synapse_Homo sapiens_hsa047251.17321828
43Amoebiasis_Homo sapiens_hsa051461.14749165
44Long-term depression_Homo sapiens_hsa047301.14251928
45T cell receptor signaling pathway_Homo sapiens_hsa046601.13512251
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13503946
47Bladder cancer_Homo sapiens_hsa052191.12385547
48Phagosome_Homo sapiens_hsa041451.06707570
49Gastric acid secretion_Homo sapiens_hsa049711.00243186
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97788048
51Oxytocin signaling pathway_Homo sapiens_hsa049210.97715871
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96367843
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96032715
54Cardiac muscle contraction_Homo sapiens_hsa042600.95409707
55Renin secretion_Homo sapiens_hsa049240.95398721
56Leishmaniasis_Homo sapiens_hsa051400.95231151
57VEGF signaling pathway_Homo sapiens_hsa043700.94491234
58Chemokine signaling pathway_Homo sapiens_hsa040620.94404250
59Hematopoietic cell lineage_Homo sapiens_hsa046400.93952924
60Viral myocarditis_Homo sapiens_hsa054160.93722141
61Endocytosis_Homo sapiens_hsa041440.91600936
62cAMP signaling pathway_Homo sapiens_hsa040240.91296056
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91091056
64Notch signaling pathway_Homo sapiens_hsa043300.90725661
65Cocaine addiction_Homo sapiens_hsa050300.90091726
66Measles_Homo sapiens_hsa051620.88688271
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88228451
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85078073
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83097183
70Osteoclast differentiation_Homo sapiens_hsa043800.82664441
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82297534
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.81803152
73Parkinsons disease_Homo sapiens_hsa050120.79123317
74Hepatitis C_Homo sapiens_hsa051600.78015237
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76657964
76Antigen processing and presentation_Homo sapiens_hsa046120.75413692
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74441239
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73940230
79Shigellosis_Homo sapiens_hsa051310.73840093
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.73523610
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73123164
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72812461
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.72534997
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72077498
85Alzheimers disease_Homo sapiens_hsa050100.72043353
86TNF signaling pathway_Homo sapiens_hsa046680.70752600
87Influenza A_Homo sapiens_hsa051640.69658710
88Galactose metabolism_Homo sapiens_hsa000520.69602506
89Tuberculosis_Homo sapiens_hsa051520.69461228
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69380603
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.68140862
92Dilated cardiomyopathy_Homo sapiens_hsa054140.67264698
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67142178
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66128290
95Fructose and mannose metabolism_Homo sapiens_hsa000510.64485112
96Apoptosis_Homo sapiens_hsa042100.64341244
97Acute myeloid leukemia_Homo sapiens_hsa052210.63777590
98GnRH signaling pathway_Homo sapiens_hsa049120.62584031
99African trypanosomiasis_Homo sapiens_hsa051430.61637601
100MAPK signaling pathway_Homo sapiens_hsa040100.61300079
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60846761
102Staphylococcus aureus infection_Homo sapiens_hsa051500.60328125
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.59848366
104Salmonella infection_Homo sapiens_hsa051320.58924732
105Mineral absorption_Homo sapiens_hsa049780.55621569
106PPAR signaling pathway_Homo sapiens_hsa033200.55167226
107Type II diabetes mellitus_Homo sapiens_hsa049300.54165226
108Estrogen signaling pathway_Homo sapiens_hsa049150.52393637
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52361776
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.52068614
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50836020
112Pertussis_Homo sapiens_hsa051330.50264467
113Gap junction_Homo sapiens_hsa045400.50092419
114Other glycan degradation_Homo sapiens_hsa005110.49847826
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49789949
116Chronic myeloid leukemia_Homo sapiens_hsa052200.48137017
117Legionellosis_Homo sapiens_hsa051340.47039131
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.46971190
119Regulation of autophagy_Homo sapiens_hsa041400.46897811
120Renal cell carcinoma_Homo sapiens_hsa052110.46491053
121Lysosome_Homo sapiens_hsa041420.45847034
122ECM-receptor interaction_Homo sapiens_hsa045120.45707261
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45138897
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44470899
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42788432
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42698628
127mTOR signaling pathway_Homo sapiens_hsa041500.42355119
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42262241
129Hepatitis B_Homo sapiens_hsa051610.40753500
130Focal adhesion_Homo sapiens_hsa045100.40616639
131Vitamin B6 metabolism_Homo sapiens_hsa007500.40028199
132Prolactin signaling pathway_Homo sapiens_hsa049170.39957276
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38840549
134Rap1 signaling pathway_Homo sapiens_hsa040150.38223068
135Inositol phosphate metabolism_Homo sapiens_hsa005620.37436525
136Proteoglycans in cancer_Homo sapiens_hsa052050.36129245
137Circadian rhythm_Homo sapiens_hsa047100.36048467
138B cell receptor signaling pathway_Homo sapiens_hsa046620.35339232
139Toxoplasmosis_Homo sapiens_hsa051450.34891367
140HIF-1 signaling pathway_Homo sapiens_hsa040660.34224490
141Pancreatic cancer_Homo sapiens_hsa052120.32950780
142Glioma_Homo sapiens_hsa052140.32900081
143ErbB signaling pathway_Homo sapiens_hsa040120.31131076
144Insulin signaling pathway_Homo sapiens_hsa049100.30143737
145Glutathione metabolism_Homo sapiens_hsa004800.29138677
146Insulin resistance_Homo sapiens_hsa049310.28942041

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