IFIT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type I interferon signaling pathway (GO:0060337)6.29042890
2cellular response to type I interferon (GO:0071357)6.29042890
3response to type I interferon (GO:0034340)6.16121841
4cellular response to interferon-alpha (GO:0035457)5.37504801
5response to interferon-alpha (GO:0035455)5.03122775
6regulation of interferon-alpha production (GO:0032647)4.45668317
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44579276
8negative regulation of cell killing (GO:0031342)4.44579276
9negative regulation of interleukin-12 production (GO:0032695)4.41924245
10positive regulation by symbiont of host defense response (GO:0052509)4.36367834
11modulation by symbiont of host defense response (GO:0052031)4.36367834
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36367834
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36367834
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.36367834
15modulation by symbiont of host immune response (GO:0052553)4.36367834
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34638779
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29611297
18negative regulation of viral genome replication (GO:0045071)4.23434762
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.20827935
20macrophage activation involved in immune response (GO:0002281)4.19543751
21positive regulation of interferon-alpha production (GO:0032727)4.18561244
22positive regulation of gamma-delta T cell activation (GO:0046645)4.09479976
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05184438
24regulation of interferon-beta biosynthetic process (GO:0045357)3.96691424
25interferon-gamma-mediated signaling pathway (GO:0060333)3.94779498
26detection of molecule of bacterial origin (GO:0032490)3.88461935
27antigen processing and presentation of endogenous antigen (GO:0019883)3.70163544
28regulation of T-helper 1 cell differentiation (GO:0045625)3.64083305
29positive regulation of interferon-beta production (GO:0032728)3.59499096
30response to peptidoglycan (GO:0032494)3.55114157
31regulation of interleukin-8 biosynthetic process (GO:0045414)3.44188309
32microglial cell activation (GO:0001774)3.42861532
33negative regulation of T cell mediated immunity (GO:0002710)3.40110654
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.39871939
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36782302
36response to host immune response (GO:0052572)3.36782302
37positive regulation of type 2 immune response (GO:0002830)3.35193109
38positive regulation of toll-like receptor signaling pathway (GO:0034123)3.28645143
39detection of other organism (GO:0098543)3.25026375
40regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23215091
41* defense response to virus (GO:0051607)3.20360335
42defense response to protozoan (GO:0042832)3.13633838
43interferon-gamma production (GO:0032609)3.13207430
44cellular response to interleukin-15 (GO:0071350)3.10901072
45response to interferon-beta (GO:0035456)3.09646977
46detection of external biotic stimulus (GO:0098581)3.09482816
47T cell migration (GO:0072678)3.05265996
48response to host (GO:0075136)3.04914768
49response to host defenses (GO:0052200)3.04914768
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04914768
51response to interleukin-15 (GO:0070672)3.04658597
52neutrophil mediated immunity (GO:0002446)3.03777321
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.02870681
54macrophage activation (GO:0042116)3.01620069
55NIK/NF-kappaB signaling (GO:0038061)3.01130719
56myeloid dendritic cell differentiation (GO:0043011)2.99926704
57regulation of regulatory T cell differentiation (GO:0045589)2.99599186
58regulation of RIG-I signaling pathway (GO:0039535)2.99383641
59regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97575080
60regulation of T cell tolerance induction (GO:0002664)2.96156599
61lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94672949
62regulation of cytokine secretion involved in immune response (GO:0002739)2.94477888
63regulation of type 2 immune response (GO:0002828)2.94029564
64regulation of viral genome replication (GO:0045069)2.92018393
65regulation of MHC class I biosynthetic process (GO:0045343)2.91387698
66cellular response to interferon-gamma (GO:0071346)2.85362834
67regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84820455
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83474888
69detection of bacterium (GO:0016045)2.83442956
70T-helper 1 type immune response (GO:0042088)2.81868497
71interleukin-6-mediated signaling pathway (GO:0070102)2.81542787
72regulation of interleukin-12 production (GO:0032655)2.80858341
73leukocyte aggregation (GO:0070486)2.80793817
74germinal center formation (GO:0002467)2.79841036
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79549653
76regulation of chronic inflammatory response (GO:0002676)2.79028069
77production of molecular mediator involved in inflammatory response (GO:0002532)2.77594133
78negative regulation of cytokine production involved in immune response (GO:0002719)2.77045590
79positive regulation of NF-kappaB import into nucleus (GO:0042346)2.76041088
80cellular response to exogenous dsRNA (GO:0071360)2.74327822
81regulation of vitamin D biosynthetic process (GO:0060556)2.73126563
82cellular response to interferon-beta (GO:0035458)2.72749305
83regulation of response to interferon-gamma (GO:0060330)2.71990742
84regulation of interferon-beta production (GO:0032648)2.71300887
85response to protozoan (GO:0001562)2.70720570
86negative regulation of viral process (GO:0048525)2.70318772
87response to interferon-gamma (GO:0034341)2.69251949
88activated T cell proliferation (GO:0050798)2.69011480
89regulation of gamma-delta T cell activation (GO:0046643)2.67613304
90positive regulation of acute inflammatory response (GO:0002675)2.67010694
91regulation of interleukin-1 beta secretion (GO:0050706)2.66950828
92interferon-gamma secretion (GO:0072643)2.65802825
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.65658342
94regulation of B cell receptor signaling pathway (GO:0050855)2.65612662
95myeloid leukocyte mediated immunity (GO:0002444)2.65494398
96positive regulation of natural killer cell differentiation (GO:0032825)2.64876643
97negative regulation of type 2 immune response (GO:0002829)2.64678190
98immunoglobulin mediated immune response (GO:0016064)2.61801831
99detection of biotic stimulus (GO:0009595)2.59792199
100neutrophil activation involved in immune response (GO:0002283)2.59107194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.95760536
2SMAD_19615063_ChIP-ChIP_OVARY_Human5.17767149
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.66316157
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.50364266
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.45821528
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.35937911
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98984461
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.89682449
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.75431640
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52672047
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37368177
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24938506
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20099906
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13074594
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05634547
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02931594
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99955878
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96925743
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89560368
20GATA1_22025678_ChIP-Seq_K562_Human1.88687525
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87056440
22GBX2_23144817_ChIP-Seq_PC3_Human1.84153599
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78077469
24VDR_24787735_ChIP-Seq_THP-1_Human1.67465452
25RUNX_20019798_ChIP-Seq_JUKART_Human1.64255039
26IGF1R_20145208_ChIP-Seq_DFB_Human1.62121147
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57765962
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.54963959
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54238054
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50528739
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48704977
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46336125
33TAF15_26573619_Chip-Seq_HEK293_Human1.45334452
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.44789067
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42982352
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41769294
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36195200
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32491100
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31220400
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30863561
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28513361
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28513361
43P300_19829295_ChIP-Seq_ESCs_Human1.24799801
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.23622978
45GATA3_26560356_Chip-Seq_TH2_Human1.23410670
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21523036
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21059287
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17013655
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15817021
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.14986258
51SPI1_23547873_ChIP-Seq_NB4_Human1.14399251
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14005619
53* MYB_26560356_Chip-Seq_TH2_Human1.13330587
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10697881
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10608670
56ER_23166858_ChIP-Seq_MCF-7_Human1.10482297
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.10383673
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.08044021
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.06666184
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.06511915
61SMAD4_21799915_ChIP-Seq_A2780_Human1.06326425
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.05243956
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03686468
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03325860
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.02463504
66P53_22387025_ChIP-Seq_ESCs_Mouse1.02175611
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01582588
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00738104
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.00249711
70TAL1_26923725_Chip-Seq_HPCs_Mouse0.98078732
71E2F1_18555785_Chip-Seq_ESCs_Mouse0.98029194
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97407444
73CJUN_26792858_Chip-Seq_BT549_Human0.96631511
74STAT3_23295773_ChIP-Seq_U87_Human0.96319255
75BRD4_25478319_ChIP-Seq_HGPS_Human0.96228960
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95967280
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94475505
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94279425
79TP53_16413492_ChIP-PET_HCT116_Human0.93093543
80TP53_18474530_ChIP-ChIP_U2OS_Human0.93070016
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.92494867
82OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92212569
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90961983
84FLI1_21867929_ChIP-Seq_TH2_Mouse0.90669871
85PU_27001747_Chip-Seq_BMDM_Mouse0.90600008
86NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89944797
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89675716
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.88792767
89KDM2B_26808549_Chip-Seq_REH_Human0.85727973
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85027941
91CBP_20019798_ChIP-Seq_JUKART_Human0.85027941
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83523908
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.83049137
94P300_18555785_Chip-Seq_ESCs_Mouse0.83048192
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81989608
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.81720245
97AR_25329375_ChIP-Seq_VCAP_Human0.81542110
98SOX2_20726797_ChIP-Seq_SW620_Human0.80984446
99CDX2_22108803_ChIP-Seq_LS180_Human0.80866870
100SMRT_27268052_Chip-Seq_Bcells_Human0.80039971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.42814772
2MP0003303_peritoneal_inflammation4.37592650
3MP0001835_abnormal_antigen_presentation3.86730417
4MP0006082_CNS_inflammation3.46660786
5MP0009785_altered_susceptibility_to3.43959514
6MP0001790_abnormal_immune_system2.91278127
7MP0005387_immune_system_phenotype2.91278127
8MP0003436_decreased_susceptibility_to2.83573269
9MP0000569_abnormal_digit_pigmentation2.69510994
10MP0005000_abnormal_immune_tolerance2.54831685
11MP0004510_myositis2.48436893
12MP0005671_abnormal_response_to2.47881792
13MP0002148_abnormal_hypersensitivity_rea2.44651081
14MP0001800_abnormal_humoral_immune2.43761580
15MP0005025_abnormal_response_to2.41452476
16MP0002419_abnormal_innate_immunity2.27630033
17MP0002723_abnormal_immune_serum2.25222982
18MP0003300_gastrointestinal_ulcer2.21515601
19MP0000685_abnormal_immune_system2.16642603
20MP0002452_abnormal_antigen_presenting2.12030290
21MP0009764_decreased_sensitivity_to2.11121520
22MP0004883_abnormal_blood_vessel1.94925582
23MP0006054_spinal_hemorrhage1.91105714
24MP0002332_abnormal_exercise_endurance1.89203379
25MP0001533_abnormal_skeleton_physiology1.79767516
26MP0001819_abnormal_immune_cell1.78178569
27MP0002420_abnormal_adaptive_immunity1.78040974
28MP0003191_abnormal_cellular_cholesterol1.72376714
29MP0001845_abnormal_inflammatory_respons1.72118196
30MP0005164_abnormal_response_to1.67241692
31MP0002405_respiratory_system_inflammati1.59688894
32MP0003221_abnormal_cardiomyocyte_apopto1.59234961
33MP0003690_abnormal_glial_cell1.57437949
34MP0000465_gastrointestinal_hemorrhage1.56583567
35MP0010155_abnormal_intestine_physiology1.51768296
36MP0008469_abnormal_protein_level1.47005090
37MP0008260_abnormal_autophagy1.46004818
38MP0005310_abnormal_salivary_gland1.45468199
39MP0003656_abnormal_erythrocyte_physiolo1.44556154
40MP0000343_altered_response_to1.35969669
41MP0004947_skin_inflammation1.30807084
42MP0003448_altered_tumor_morphology1.26166654
43MP0002277_abnormal_respiratory_mucosa1.25220327
44MP0003075_altered_response_to1.24115081
45MP0000716_abnormal_immune_system1.23962169
46MP0000604_amyloidosis1.23378112
47MP0003183_abnormal_peptide_metabolism1.22971147
48MP0001542_abnormal_bone_strength1.15111381
49MP0003195_calcinosis1.11087820
50MP0005248_abnormal_Harderian_gland1.10926971
51MP0003172_abnormal_lysosome_physiology1.10655927
52MP0003950_abnormal_plasma_membrane1.10556382
53MP0002163_abnormal_gland_morphology1.09274453
54MP0003787_abnormal_imprinting1.06808700
55MP0005623_abnormal_meninges_morphology1.06647972
56MP0003763_abnormal_thymus_physiology1.05164718
57MP0003091_abnormal_cell_migration1.04484017
58MP0002398_abnormal_bone_marrow1.01235773
59MP0005084_abnormal_gallbladder_morpholo1.00074705
60MP0005166_decreased_susceptibility_to0.97965974
61MP0002102_abnormal_ear_morphology0.97534588
62MP0000689_abnormal_spleen_morphology0.96023047
63MP0008004_abnormal_stomach_pH0.94115914
64MP0009763_increased_sensitivity_to0.93891277
65MP0010386_abnormal_urinary_bladder0.91413936
66MP0002166_altered_tumor_susceptibility0.89154246
67MP0001958_emphysema0.89025405
68MP0003045_fibrosis0.88071840
69MP0003866_abnormal_defecation0.87816899
70MP0002722_abnormal_immune_system0.81645261
71MP0003633_abnormal_nervous_system0.80775829
72MP0001529_abnormal_vocalization0.80511402
73MP0002998_abnormal_bone_remodeling0.78926549
74MP0008874_decreased_physiological_sensi0.78588176
75MP0002693_abnormal_pancreas_physiology0.78156801
76MP0002429_abnormal_blood_cell0.77632371
77MP0000249_abnormal_blood_vessel0.76676450
78MP0000858_altered_metastatic_potential0.75638030
79MP0005390_skeleton_phenotype0.75577755
80MP0003252_abnormal_bile_duct0.74668613
81MP0005535_abnormal_body_temperature0.74630320
82MP0005167_abnormal_blood-brain_barrier0.73935677
83MP0002006_tumorigenesis0.72602551
84MP0005379_endocrine/exocrine_gland_phen0.72472924
85MP0000371_diluted_coat_color0.72114102
86MP0009765_abnormal_xenobiotic_induced0.71185383
87MP0001851_eye_inflammation0.70817368
88MP0005376_homeostasis/metabolism_phenot0.69561661
89MP0000920_abnormal_myelination0.68754474
90MP0003828_pulmonary_edema0.68541801
91MP0001853_heart_inflammation0.67910165
92MP0003329_amyloid_beta_deposits0.67491908
93MP0002168_other_aberrant_phenotype0.65646280
94MP0005451_abnormal_body_composition0.65424099
95MP0002653_abnormal_ependyma_morphology0.64205492
96MP0001501_abnormal_sleep_pattern0.63300098
97MP0005266_abnormal_metabolism0.63029713
98MP0004142_abnormal_muscle_tone0.61927294
99MP0005464_abnormal_platelet_physiology0.60706305
100MP0005397_hematopoietic_system_phenotyp0.58480487

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.98084890
2Optic neuritis (HP:0100653)5.98084890
3Orchitis (HP:0100796)5.75396739
4Myositis (HP:0100614)5.03826743
5Stomatitis (HP:0010280)4.96820020
6Recurrent bacterial skin infections (HP:0005406)4.44317910
7Eczematoid dermatitis (HP:0000976)4.28433232
8Recurrent abscess formation (HP:0002722)4.13439560
9Chronic mucocutaneous candidiasis (HP:0002728)4.06075424
10Recurrent cutaneous fungal infections (HP:0011370)4.06075424
11Keratoconjunctivitis sicca (HP:0001097)4.03681062
12Keratoconjunctivitis (HP:0001096)3.87699573
13Abnormality of macrophages (HP:0004311)3.85136846
14Recurrent fungal infections (HP:0002841)3.71828765
15Abnormality of T cell number (HP:0011839)3.57054955
16T lymphocytopenia (HP:0005403)3.56998453
17Recurrent skin infections (HP:0001581)3.42319793
18Mediastinal lymphadenopathy (HP:0100721)3.41575975
19Hemoptysis (HP:0002105)3.32751014
20Increased IgM level (HP:0003496)3.32382724
21Elevated erythrocyte sedimentation rate (HP:0003565)3.30627284
22Pulmonary infiltrates (HP:0002113)3.27486462
23Recurrent gram-negative bacterial infections (HP:0005420)3.22497728
24Gingivitis (HP:0000230)3.07729700
25Vasculitis (HP:0002633)3.07138995
26Hypochromic microcytic anemia (HP:0004840)2.96547910
27Cheilitis (HP:0100825)2.94069092
28Gastrointestinal infarctions (HP:0005244)2.93620043
29Encephalitis (HP:0002383)2.92983236
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.79410824
31Abnormality of liposaccharide metabolism (HP:0010968)2.69796818
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.69796818
33Abnormality of glycolipid metabolism (HP:0010969)2.69796818
34Episodic fever (HP:0001954)2.67679169
35Loss of speech (HP:0002371)2.60804943
36Joint swelling (HP:0001386)2.59648587
37Disinhibition (HP:0000734)2.58847904
38Hematochezia (HP:0002573)2.55605823
39Vacuolated lymphocytes (HP:0001922)2.49219317
40Recurrent viral infections (HP:0004429)2.48060158
41Recurrent bronchitis (HP:0002837)2.43226783
42Gangrene (HP:0100758)2.39921413
43Abnormality of the endocardium (HP:0004306)2.34667880
44Interstitial pulmonary disease (HP:0006530)2.32752443
45Hypergammaglobulinemia (HP:0010702)2.32479635
46Peritonitis (HP:0002586)2.31538886
47Chronic otitis media (HP:0000389)2.30850162
48Abnormality of the musculature of the pelvis (HP:0001469)2.26232825
49Abnormality of the hip-girdle musculature (HP:0001445)2.26232825
50Leukocytosis (HP:0001974)2.25979130
51Meningitis (HP:0001287)2.23246301
52Abnormality of the pleura (HP:0002103)2.21706230
53Abnormality of T cells (HP:0002843)2.20993337
54Amyotrophic lateral sclerosis (HP:0007354)2.17218724
55Keratitis (HP:0000491)2.16864681
56Anorexia (HP:0002039)2.16564629
57Chronic diarrhea (HP:0002028)2.16442228
58Urticaria (HP:0001025)2.14984550
59Abnormality of the pericardium (HP:0001697)2.09906569
60Arterial thrombosis (HP:0004420)2.07147963
61Gingival bleeding (HP:0000225)2.04383092
62Eosinophilia (HP:0001880)2.02767864
63Mutism (HP:0002300)1.98667895
64Inappropriate behavior (HP:0000719)1.97022588
65Neoplasm of the tracheobronchial system (HP:0100552)1.96557926
66Parakeratosis (HP:0001036)1.96119967
67Spontaneous hematomas (HP:0007420)1.95452202
68Amyloidosis (HP:0011034)1.95022964
69Absent speech (HP:0001344)1.92704412
70Degeneration of the lateral corticospinal tracts (HP:0002314)1.92604297
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92604297
72Autoimmune hemolytic anemia (HP:0001890)1.90476181
73Papilledema (HP:0001085)1.88790002
74Excessive salivation (HP:0003781)1.87319278
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87225676
76Autoimmune thrombocytopenia (HP:0001973)1.86427272
77Albinism (HP:0001022)1.85004098
78Absent frontal sinuses (HP:0002688)1.84932737
79Progressive inability to walk (HP:0002505)1.84845912
80Subacute progressive viral hepatitis (HP:0006572)1.84179256
81IgG deficiency (HP:0004315)1.83447914
82Abnormality of eosinophils (HP:0001879)1.82726057
83Polyneuropathy (HP:0001271)1.82002807
84Chest pain (HP:0100749)1.79676041
85Memory impairment (HP:0002354)1.79381339
86Alveolar cell carcinoma (HP:0006519)1.78482767
87IgA deficiency (HP:0002720)1.78116630
88Progressive neurologic deterioration (HP:0002344)1.77837358
89Pulmonary embolism (HP:0002204)1.77206535
90Glomerulopathy (HP:0100820)1.77046413
91Pelvic girdle muscle weakness (HP:0003749)1.75937738
92Hypochromic anemia (HP:0001931)1.74360535
93Abnormality of salivation (HP:0100755)1.72839840
94Basal ganglia calcification (HP:0002135)1.71175975
95Stomach cancer (HP:0012126)1.70827402
96Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69183752
97Medulloblastoma (HP:0002885)1.68666122
98Lymphopenia (HP:0001888)1.68143140
99Abnormality of T cell physiology (HP:0011840)1.66598153
100Thyroiditis (HP:0100646)1.66198630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.65500136
2EPHA33.07447347
3GRK72.84781520
4IKBKE2.78198164
5MAP3K142.67569999
6JAK12.57007023
7TXK2.50520644
8BCR2.35345261
9IRAK42.16121571
10EPHB12.07922417
11RIPK42.05709054
12TAOK22.03518313
13SIK31.96682597
14BLK1.90738778
15CSK1.84450268
16CAMKK21.75355631
17TBK11.70977226
18MAP4K21.68928849
19FGFR31.66232254
20MAP4K11.58285046
21ERBB31.52277965
22JAK31.51320585
23FGR1.50663352
24BMPR21.48830538
25MAP3K41.46880229
26MAP2K71.43485755
27CASK1.41541803
28TAOK11.37812503
29MAP3K51.36327415
30MAP3K31.35677707
31IRAK11.31510225
32MAP3K121.29881454
33JAK21.29515759
34PAK31.29038849
35KIT1.26078030
36YES11.25789111
37IKBKB1.24241601
38IRAK31.17370728
39MATK1.15506995
40FRK1.14019413
41DDR21.13248449
42ADRBK21.12556526
43HCK1.07977406
44FGFR41.06742380
45RIPK11.04906742
46DYRK31.04841435
47TAOK31.02539161
48KSR10.99307662
49MAP2K30.98182458
50TRIM280.94323904
51MAP2K40.93566968
52NEK90.91091147
53LYN0.90702947
54SYK0.87054835
55FES0.84214447
56IRAK20.83567955
57PRPF4B0.82603982
58CHUK0.78055901
59LCK0.77148080
60CSNK1G20.74981952
61MARK10.74391946
62PTK2B0.74223522
63CSNK1A1L0.73721525
64TGFBR20.73523338
65MAP2K60.72489740
66DYRK1B0.72075178
67SIK20.70325454
68CSNK1G30.69211250
69MAP3K60.69182907
70MARK30.69052889
71ZAP700.67794360
72FER0.66914018
73SGK20.65362830
74MAPK130.62572770
75NLK0.61066365
76BTK0.58894324
77PRKD20.58620679
78CSNK1G10.55348778
79HIPK20.54799988
80EGFR0.54012680
81WNK30.53430827
82PIM20.52527024
83PRKCE0.51411387
84MAP3K10.50518561
85MOS0.47300972
86DYRK1A0.46988772
87MAP3K20.46520197
88PDGFRB0.45264670
89PINK10.45023756
90ABL10.44067442
91CSF1R0.43564676
92MAPK70.43172264
93PRKCQ0.43003763
94STK240.42018035
95TEC0.40498837
96SGK30.40298622
97STK380.38835232
98INSR0.38549859
99GRK60.38399273
100FYN0.38055706

Predicted pathways (KEGG)

RankGene SetZ-score
1RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.83401115
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.81729490
3Osteoclast differentiation_Homo sapiens_hsa043802.72672781
4Measles_Homo sapiens_hsa051622.67579358
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31389746
6Allograft rejection_Homo sapiens_hsa053302.24042914
7Leishmaniasis_Homo sapiens_hsa051402.22770608
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19492082
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.18637168
10Influenza A_Homo sapiens_hsa051642.04885045
11TNF signaling pathway_Homo sapiens_hsa046681.98553871
12Malaria_Homo sapiens_hsa051441.97902968
13Graft-versus-host disease_Homo sapiens_hsa053321.93554385
14Tuberculosis_Homo sapiens_hsa051521.90632567
15African trypanosomiasis_Homo sapiens_hsa051431.88072197
16Legionellosis_Homo sapiens_hsa051341.86658922
17Staphylococcus aureus infection_Homo sapiens_hsa051501.82891846
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.81012314
19Hepatitis C_Homo sapiens_hsa051601.80850352
20Autoimmune thyroid disease_Homo sapiens_hsa053201.80593254
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75814439
22Type I diabetes mellitus_Homo sapiens_hsa049401.73838037
23Rheumatoid arthritis_Homo sapiens_hsa053231.72228428
24Herpes simplex infection_Homo sapiens_hsa051681.66347196
25Pertussis_Homo sapiens_hsa051331.64325777
26Phagosome_Homo sapiens_hsa041451.61375394
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59550886
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.56391141
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.56205648
30Toxoplasmosis_Homo sapiens_hsa051451.54256610
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51967118
32Hepatitis B_Homo sapiens_hsa051611.50750634
33Chemokine signaling pathway_Homo sapiens_hsa040621.45998266
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45115661
35Salmonella infection_Homo sapiens_hsa051321.34506093
36Shigellosis_Homo sapiens_hsa051311.25373267
37Collecting duct acid secretion_Homo sapiens_hsa049661.19310183
38Primary immunodeficiency_Homo sapiens_hsa053401.19065152
39Hematopoietic cell lineage_Homo sapiens_hsa046401.17354387
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14999002
41Viral myocarditis_Homo sapiens_hsa054161.14798584
42Asthma_Homo sapiens_hsa053101.13497046
43T cell receptor signaling pathway_Homo sapiens_hsa046601.10914993
44Prolactin signaling pathway_Homo sapiens_hsa049171.09397792
45B cell receptor signaling pathway_Homo sapiens_hsa046621.01077122
46Lysosome_Homo sapiens_hsa041420.98332731
47Antigen processing and presentation_Homo sapiens_hsa046120.97649822
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95030255
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93399754
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91524389
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81580370
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81263505
53Apoptosis_Homo sapiens_hsa042100.79769273
54Type II diabetes mellitus_Homo sapiens_hsa049300.79601270
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76015313
56Dorso-ventral axis formation_Homo sapiens_hsa043200.75865832
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75669087
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.69594438
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68954976
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68437742
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.66520864
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.61845533
63Regulation of autophagy_Homo sapiens_hsa041400.61737736
64FoxO signaling pathway_Homo sapiens_hsa040680.60547044
65Vibrio cholerae infection_Homo sapiens_hsa051100.59640828
66Epstein-Barr virus infection_Homo sapiens_hsa051690.57893954
67Sphingolipid metabolism_Homo sapiens_hsa006000.53489933
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51238274
69Acute myeloid leukemia_Homo sapiens_hsa052210.51161916
70Endocytosis_Homo sapiens_hsa041440.50630326
71Pancreatic cancer_Homo sapiens_hsa052120.48879126
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47738039
73Other glycan degradation_Homo sapiens_hsa005110.47310963
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46898329
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.46140929
76Circadian rhythm_Homo sapiens_hsa047100.45847669
77Amoebiasis_Homo sapiens_hsa051460.42206257
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41704219
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.36353239
80MAPK signaling pathway_Homo sapiens_hsa040100.36237006
81Platelet activation_Homo sapiens_hsa046110.34973165
82Viral carcinogenesis_Homo sapiens_hsa052030.34846947
83mTOR signaling pathway_Homo sapiens_hsa041500.34038345
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32402390
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29812090
86Synaptic vesicle cycle_Homo sapiens_hsa047210.29304959
87Cocaine addiction_Homo sapiens_hsa050300.29259119
88Protein export_Homo sapiens_hsa030600.29258030
89Insulin resistance_Homo sapiens_hsa049310.28884703
90GnRH signaling pathway_Homo sapiens_hsa049120.28844407
91Renal cell carcinoma_Homo sapiens_hsa052110.28081169
92Complement and coagulation cascades_Homo sapiens_hsa046100.27655036
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26314807
94GABAergic synapse_Homo sapiens_hsa047270.24823934
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24142689
96Inositol phosphate metabolism_Homo sapiens_hsa005620.22965646
97HIF-1 signaling pathway_Homo sapiens_hsa040660.20417122
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20371670
99Fatty acid biosynthesis_Homo sapiens_hsa000610.19802701
100Rap1 signaling pathway_Homo sapiens_hsa040150.19720867

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