IFIT1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gas transport (GO:0015669)9.87639535
2protoporphyrinogen IX biosynthetic process (GO:0006782)9.08704821
3porphyrin-containing compound biosynthetic process (GO:0006779)8.24116664
4erythrocyte development (GO:0048821)7.42693804
5erythrocyte maturation (GO:0043249)7.35195168
6tetrapyrrole biosynthetic process (GO:0033014)7.24530761
7porphyrin-containing compound metabolic process (GO:0006778)6.92096503
8heme biosynthetic process (GO:0006783)6.83394859
9heme metabolic process (GO:0042168)5.75567733
10myeloid cell development (GO:0061515)5.59948167
11response to methylmercury (GO:0051597)5.45383491
12regulation of response to osmotic stress (GO:0047484)4.72188832
13defense response to fungus (GO:0050832)4.54827255
14hepatocyte apoptotic process (GO:0097284)4.52904999
15innate immune response in mucosa (GO:0002227)4.38095761
16killing of cells of other organism (GO:0031640)4.37137428
17disruption of cells of other organism (GO:0044364)4.37137428
18antibacterial humoral response (GO:0019731)4.25763868
19tetrapyrrole metabolic process (GO:0033013)4.18672068
203-UTR-mediated mRNA stabilization (GO:0070935)4.13997380
21positive regulation of granulocyte differentiation (GO:0030854)4.13181009
22glycine transport (GO:0015816)4.10965292
23detection of other organism (GO:0098543)4.04825822
24antimicrobial humoral response (GO:0019730)3.95127555
25positive regulation of gamma-delta T cell activation (GO:0046645)3.92644948
26microglial cell activation (GO:0001774)3.92223909
27neutrophil activation involved in immune response (GO:0002283)3.91181528
28detection of bacterium (GO:0016045)3.90885866
29megakaryocyte development (GO:0035855)3.78340552
30response to peptidoglycan (GO:0032494)3.68795061
31mucosal immune response (GO:0002385)3.68549336
32negative regulation of erythrocyte differentiation (GO:0045647)3.67296722
33cellular response to virus (GO:0098586)3.62733693
34regulation of platelet aggregation (GO:0090330)3.62474417
35organ or tissue specific immune response (GO:0002251)3.59931450
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50100442
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.50100442
38modulation by symbiont of host immune response (GO:0052553)3.50100442
39positive regulation by symbiont of host defense response (GO:0052509)3.50100442
40modulation by symbiont of host defense response (GO:0052031)3.50100442
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50100442
42response to fungus (GO:0009620)3.47207124
43definitive hemopoiesis (GO:0060216)3.45848486
44erythrocyte differentiation (GO:0030218)3.45231726
45cellular extravasation (GO:0045123)3.43087067
46negative regulation of execution phase of apoptosis (GO:1900118)3.41958547
47regulation of B cell receptor signaling pathway (GO:0050855)3.36408334
48negative regulation of cell killing (GO:0031342)3.36344079
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36344079
50positive regulation of fibroblast migration (GO:0010763)3.35788998
51detection of external biotic stimulus (GO:0098581)3.35342505
52modulation by virus of host process (GO:0019054)3.32666744
53neutrophil activation (GO:0042119)3.29790086
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.29737813
55granulocyte activation (GO:0036230)3.22711711
56granulocyte differentiation (GO:0030851)3.22360047
57neutrophil mediated immunity (GO:0002446)3.19963660
58hydrogen peroxide catabolic process (GO:0042744)3.16949230
59response to arsenic-containing substance (GO:0046685)3.13380148
60response to insecticide (GO:0017085)3.12033259
61regulation of erythrocyte differentiation (GO:0045646)3.08755110
62positive thymic T cell selection (GO:0045059)3.07998008
63embryonic hemopoiesis (GO:0035162)3.05981923
64response to lead ion (GO:0010288)3.03074362
65very-low-density lipoprotein particle assembly (GO:0034379)3.02980242
66negative regulation of glial cell proliferation (GO:0060253)3.02557484
67positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.01089465
68regulation of granulocyte differentiation (GO:0030852)2.98052282
69response to host immune response (GO:0052572)2.96115397
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96115397
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95183831
72mitochondrion degradation (GO:0000422)2.93319800
73positive regulation of erythrocyte differentiation (GO:0045648)2.91560258
74positive T cell selection (GO:0043368)2.91208705
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88144326
76intracellular estrogen receptor signaling pathway (GO:0030520)2.85900280
77detection of molecule of bacterial origin (GO:0032490)2.85576363
78leukocyte aggregation (GO:0070486)2.84909068
79macrophage activation involved in immune response (GO:0002281)2.83902613
80detection of biotic stimulus (GO:0009595)2.83723823
81modulation by symbiont of host cellular process (GO:0044068)2.83003954
82macrophage activation (GO:0042116)2.81381432
83killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.78799596
84disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.78799596
85leukocyte migration involved in inflammatory response (GO:0002523)2.77180162
86regulation of mast cell degranulation (GO:0043304)2.77011683
87regulation of necroptotic process (GO:0060544)2.76812378
88iron ion import (GO:0097286)2.76156986
89regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.75576751
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75043779
91one-carbon compound transport (GO:0019755)2.73075988
92platelet formation (GO:0030220)2.69667076
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67071246
94response to host (GO:0075136)2.67071246
95response to host defenses (GO:0052200)2.67071246
96bicarbonate transport (GO:0015701)2.66992414
97defense response to Gram-positive bacterium (GO:0050830)2.66746024
98protoporphyrinogen IX metabolic process (GO:0046501)11.7613151
99oxygen transport (GO:0015671)11.3939920
100hemoglobin metabolic process (GO:0020027)10.3586782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human7.48265199
2GATA1_19941826_ChIP-Seq_K562_Human5.77403786
3SCL_19346495_ChIP-Seq_HPC-7_Human4.78661213
4GATA2_19941826_ChIP-Seq_K562_Human3.67660477
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41472986
6E2F7_22180533_ChIP-Seq_HELA_Human3.40757397
7TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.37419339
8GATA1_19941827_ChIP-Seq_MEL_Mouse3.33524750
9KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.17704443
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.10795891
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72798091
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.64841634
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58831946
14VDR_21846776_ChIP-Seq_THP-1_Human2.44828193
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42547778
16GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.34416557
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31171126
18VDR_24763502_ChIP-Seq_THP-1_Human2.29350589
19GATA1_22383799_ChIP-Seq_G1ME_Mouse2.25401487
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25090744
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15476840
22TCF7_22412390_ChIP-Seq_EML_Mouse2.10923525
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.09351260
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09215604
25SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.07952881
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07366906
27MYC_22102868_ChIP-Seq_BL_Human2.06373027
28SPI1_23547873_ChIP-Seq_NB4_Human2.03747956
29MYB_26560356_Chip-Seq_TH2_Human2.03683932
30MAF_26560356_Chip-Seq_TH1_Human2.03388950
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.00020518
32RUNX_20019798_ChIP-Seq_JUKART_Human1.94474854
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91254943
34MYB_26560356_Chip-Seq_TH1_Human1.89370108
35SPI1_23127762_ChIP-Seq_K562_Human1.88989933
36UTX_26944678_Chip-Seq_JUKART_Human1.87983523
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.87487059
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84945796
39GATA2_22383799_ChIP-Seq_G1ME_Mouse1.81213578
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.79309102
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74280181
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73024249
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71118472
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69734790
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69624583
46KDM2B_26808549_Chip-Seq_DND41_Human1.69187735
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61159991
48NCOR1_26117541_ChIP-Seq_K562_Human1.60988645
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60318378
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59679061
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55527339
52GATA3_27048872_Chip-Seq_THYMUS_Human1.50679252
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49146784
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45253767
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44821224
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44696716
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40941488
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40497598
59TFEB_21752829_ChIP-Seq_HELA_Human1.32898300
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32821963
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32400878
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.31377559
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31341243
64PU_27001747_Chip-Seq_BMDM_Mouse1.30348797
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28428233
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.25166715
67MAF_26560356_Chip-Seq_TH2_Human1.23823883
68FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23619268
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22733451
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21268284
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19181733
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17363637
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11411878
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.08655599
75VDR_24787735_ChIP-Seq_THP-1_Human1.07212142
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.04220971
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03297624
78GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00951500
79GATA3_26560356_Chip-Seq_TH2_Human0.95921840
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.95803719
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95272840
82RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94688687
83CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92955707
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92610022
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91524061
86BCOR_27268052_Chip-Seq_Bcells_Human0.90810237
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.89524375
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87850244
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.87760765
90ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87217474
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84416437
92SMRT_27268052_Chip-Seq_Bcells_Human0.83591064
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83345317
94BCL6_27268052_Chip-Seq_Bcells_Human0.83050751
95KDM2B_26808549_Chip-Seq_K562_Human0.81326329
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81143749
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.80244759
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79629474
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78321400
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76105739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo8.60229830
2MP0004147_increased_porphyrin_level7.89519788
3MP0005083_abnormal_biliary_tract4.26246943
4MP0003303_peritoneal_inflammation3.45945530
5MP0008260_abnormal_autophagy3.10936127
6MP0005397_hematopoietic_system_phenotyp3.06193382
7MP0001545_abnormal_hematopoietic_system3.06193382
8MP0003172_abnormal_lysosome_physiology2.17305043
9MP0009278_abnormal_bone_marrow2.10153961
10MP0005464_abnormal_platelet_physiology2.05680813
11MP0000685_abnormal_immune_system1.98487564
12MP0003724_increased_susceptibility_to1.98394427
13MP0003436_decreased_susceptibility_to1.94744240
14MP0005025_abnormal_response_to1.92334799
15MP0005451_abnormal_body_composition1.90117511
16MP0009785_altered_susceptibility_to1.87444203
17MP0002398_abnormal_bone_marrow1.86986542
18MP0002419_abnormal_innate_immunity1.77572265
19MP0001835_abnormal_antigen_presentation1.75072660
20MP0002722_abnormal_immune_system1.63659601
21MP0004808_abnormal_hematopoietic_stem1.62185327
22MP0000689_abnormal_spleen_morphology1.58931339
23MP0002405_respiratory_system_inflammati1.56689064
24MP0003191_abnormal_cellular_cholesterol1.56410388
25MP0002420_abnormal_adaptive_immunity1.50607859
26MP0003763_abnormal_thymus_physiology1.50298416
27MP0005075_abnormal_melanosome_morpholog1.50272183
28MP0002396_abnormal_hematopoietic_system1.49863838
29MP0001819_abnormal_immune_cell1.48019455
30MP0008057_abnormal_DNA_replication1.45937624
31MP0003186_abnormal_redox_activity1.44725600
32MP0008995_early_reproductive_senescence1.42110283
33MP0001800_abnormal_humoral_immune1.39653717
34MP0005000_abnormal_immune_tolerance1.39301952
35MP0002166_altered_tumor_susceptibility1.37808503
36MP0000015_abnormal_ear_pigmentation1.37111823
37MP0009764_decreased_sensitivity_to1.36685967
38MP0002429_abnormal_blood_cell1.35809784
39MP0005636_abnormal_mineral_homeostasis1.29997015
40MP0000716_abnormal_immune_system1.28411877
41MP0000703_abnormal_thymus_morphology1.26903320
42MP0003045_fibrosis1.26838272
43MP0009333_abnormal_splenocyte_physiolog1.23535881
44MP0002723_abnormal_immune_serum1.22959881
45MP0005387_immune_system_phenotype1.21477825
46MP0001790_abnormal_immune_system1.21477825
47MP0002452_abnormal_antigen_presenting1.21419521
48MP0003221_abnormal_cardiomyocyte_apopto1.20044677
49MP0002132_abnormal_respiratory_system1.19303299
50MP0003300_gastrointestinal_ulcer1.14799401
51MP0005671_abnormal_response_to1.12834647
52MP0005076_abnormal_cell_differentiation1.11130402
53MP0006082_CNS_inflammation1.08008198
54MP0004947_skin_inflammation1.07037064
55MP0009765_abnormal_xenobiotic_induced1.06398736
56MP0002095_abnormal_skin_pigmentation1.03727801
57MP0005174_abnormal_tail_pigmentation0.99282276
58MP0010307_abnormal_tumor_latency0.98267195
59MP0005377_hearing/vestibular/ear_phenot0.95943031
60MP0003878_abnormal_ear_physiology0.95943031
61MP0005310_abnormal_salivary_gland0.95926794
62MP0003828_pulmonary_edema0.94012280
63MP0001845_abnormal_inflammatory_respons0.93858557
64MP0000569_abnormal_digit_pigmentation0.92890953
65MP0004381_abnormal_hair_follicle0.91994540
66MP0000465_gastrointestinal_hemorrhage0.90781453
67MP0003866_abnormal_defecation0.90452966
68MP0003183_abnormal_peptide_metabolism0.87488868
69MP0004130_abnormal_muscle_cell0.86979273
70MP0009931_abnormal_skin_appearance0.85011907
71MP0009763_increased_sensitivity_to0.80324254
72MP0002148_abnormal_hypersensitivity_rea0.75709441
73MP0002019_abnormal_tumor_incidence0.74295423
74MP0000858_altered_metastatic_potential0.73082974
75MP0002006_tumorigenesis0.70961397
76MP0000609_abnormal_liver_physiology0.70013454
77MP0010155_abnormal_intestine_physiology0.69989786
78MP0001663_abnormal_digestive_system0.69905789
79MP0008469_abnormal_protein_level0.69616413
80MP0002332_abnormal_exercise_endurance0.69113131
81MP0004883_abnormal_blood_vessel0.69059744
82MP0001533_abnormal_skeleton_physiology0.68519859
83MP0008874_decreased_physiological_sensi0.67520202
84MP0001851_eye_inflammation0.67311442
85MP0003111_abnormal_nucleus_morphology0.67282229
86MP0003787_abnormal_imprinting0.67261060
87MP0003453_abnormal_keratinocyte_physiol0.66088509
88MP0005621_abnormal_cell_physiology0.65567297
89MP0002138_abnormal_hepatobiliary_system0.63379636
90MP0005164_abnormal_response_to0.61172759
91MP0004185_abnormal_adipocyte_glucose0.60976080
92MP0000598_abnormal_liver_morphology0.59208368
93MP0000313_abnormal_cell_death0.58635479
94MP0006036_abnormal_mitochondrial_physio0.53375772
95MP0000343_altered_response_to0.53298654
96MP0002009_preneoplasia0.52948428
97MP0002822_catalepsy0.52834762
98MP0005319_abnormal_enzyme/_coenzyme0.52153803
99MP0001529_abnormal_vocalization0.50166556
100MP0003566_abnormal_cell_adhesion0.49693531

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.26831663
2Microcytic anemia (HP:0001935)7.96968177
3Hypochromic anemia (HP:0001931)7.06002902
4Abnormal hemoglobin (HP:0011902)5.55067703
5Cholelithiasis (HP:0001081)5.30844117
6Reticulocytosis (HP:0001923)5.28215550
7Abnormal gallbladder morphology (HP:0012437)4.79802553
8Polycythemia (HP:0001901)4.73468823
9Paralysis (HP:0003470)4.58695608
10Acanthocytosis (HP:0001927)4.47940597
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.14131841
12Toxemia of pregnancy (HP:0100603)4.03086705
13Recurrent bacterial skin infections (HP:0005406)3.58917294
14Gastrointestinal infarctions (HP:0005244)3.55949426
15Recurrent abscess formation (HP:0002722)3.50237982
16Abnormality of the gallbladder (HP:0005264)3.40204679
17Eczematoid dermatitis (HP:0000976)3.38269382
18Prolonged bleeding time (HP:0003010)3.36451775
19Abnormality of reticulocytes (HP:0004312)3.17461899
20Abnormality of iron homeostasis (HP:0011031)3.14988360
21Diaphragmatic weakness (HP:0009113)3.05151472
22Ileus (HP:0002595)3.04873864
23Abnormality of the fingertips (HP:0001211)3.04651359
24Hyperbilirubinemia (HP:0002904)3.03452584
25Urticaria (HP:0001025)2.89441831
26Abnormality of transition element cation homeostasis (HP:0011030)2.70738136
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.69570054
28Slow saccadic eye movements (HP:0000514)2.68982109
29Osteomyelitis (HP:0002754)2.67332110
30Pustule (HP:0200039)2.65653383
31Recurrent gram-negative bacterial infections (HP:0005420)2.62397426
32Epistaxis (HP:0000421)2.60276625
33Visual hallucinations (HP:0002367)2.53192763
34Cutaneous photosensitivity (HP:0000992)2.52512875
35Cholecystitis (HP:0001082)2.51358793
36Abnormal gallbladder physiology (HP:0012438)2.51358793
37Recurrent fungal infections (HP:0002841)2.50967463
38Gingival bleeding (HP:0000225)2.48931194
39Recurrent skin infections (HP:0001581)2.47703792
40Autoimmune thrombocytopenia (HP:0001973)2.47559498
41Gingivitis (HP:0000230)2.44150431
42Abnormality of macrophages (HP:0004311)2.41109208
43Myositis (HP:0100614)2.34976518
44Spontaneous hematomas (HP:0007420)2.33696064
45Chronic obstructive pulmonary disease (HP:0006510)2.30299185
46Obstructive lung disease (HP:0006536)2.30299185
47Cellulitis (HP:0100658)2.27938577
48Recurrent cutaneous fungal infections (HP:0011370)2.26652008
49Chronic mucocutaneous candidiasis (HP:0002728)2.26652008
50Stomatitis (HP:0010280)2.23541755
51Keratoconjunctivitis sicca (HP:0001097)2.20775597
52Osteomalacia (HP:0002749)2.18557887
53Recurrent viral infections (HP:0004429)2.17332255
54Increased serum ferritin (HP:0003281)2.13432467
55Leukocytosis (HP:0001974)2.10952304
56Postural instability (HP:0002172)2.10255614
57Meningitis (HP:0001287)2.09595904
58Hepatocellular carcinoma (HP:0001402)2.09166679
59Autoimmune hemolytic anemia (HP:0001890)2.07104441
60Keratoconjunctivitis (HP:0001096)2.03480771
61Orchitis (HP:0100796)2.02743286
62Anorexia (HP:0002039)2.01608622
63Vasculitis (HP:0002633)2.00553231
64Abnormality of the heme biosynthetic pathway (HP:0010472)13.1496778
65Hypochromic microcytic anemia (HP:0004840)11.9509659
66Encephalitis (HP:0002383)1.98727050
67Optic neuritis (HP:0100653)1.98059435
68Retrobulbar optic neuritis (HP:0100654)1.98059435
69Petechiae (HP:0000967)1.97872038
70T lymphocytopenia (HP:0005403)1.95314639
71Inflammation of the large intestine (HP:0002037)1.94996440
72Abnormality of T cell number (HP:0011839)1.94222511
73Pallor (HP:0000980)1.93601745
74Thrombophlebitis (HP:0004418)1.91534665
75Abnormal platelet volume (HP:0011876)1.90692434
76Orthostatic hypotension (HP:0001278)1.89222748
77Paresthesia (HP:0003401)1.88576589
78Gastrointestinal inflammation (HP:0004386)1.83538798
79Mediastinal lymphadenopathy (HP:0100721)1.81770586
80Abnormality of T cells (HP:0002843)1.72907095
81Elevated erythrocyte sedimentation rate (HP:0003565)1.71786862
82Hematochezia (HP:0002573)1.71049008
83Hypertensive crisis (HP:0100735)1.71015918
84Granulocytopenia (HP:0001913)1.68535149
85Chest pain (HP:0100749)1.67741518
86Abnormality of T cell physiology (HP:0011840)1.66658128
87Skin rash (HP:0000988)1.65998641
88Pulmonary infiltrates (HP:0002113)1.63601077
89Nausea (HP:0002018)1.61720302
90Panhypogammaglobulinemia (HP:0003139)1.60545646
91Increased mean platelet volume (HP:0011877)1.60183112
92Impaired platelet aggregation (HP:0003540)1.58043779
93Abnormal platelet function (HP:0011869)1.58043779
94Gastrointestinal dysmotility (HP:0002579)1.57772786
95Albinism (HP:0001022)1.57504420
96Splenomegaly (HP:0001744)1.56867479
97Arterial thrombosis (HP:0004420)1.55589755
98Anhidrosis (HP:0000970)1.55159142
99Hypertriglyceridemia (HP:0002155)1.54145141
100Thoracic kyphosis (HP:0002942)1.54026483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.07375600
2MAP2K34.54163551
3GRK63.65850485
4TAOK13.57630539
5PRPF4B3.48533147
6MAP3K113.28182425
7TAOK23.11658178
8MAP3K32.88060432
9RIPK42.53854182
10PIM11.94068954
11WNK11.92765089
12FGR1.92227099
13PTK2B1.85639518
14IKBKE1.74977346
15BLK1.68550240
16MAP3K11.68535823
17SYK1.65507572
18STK41.64771761
19MAP4K11.58998140
20SGK21.55820381
21CAMK1D1.46381409
22BMX1.46114190
23IRAK41.41285907
24SGK31.37894937
25FES1.33973181
26TNK21.31374470
27MARK31.29318107
28DYRK31.27263550
29MAP3K51.26309213
30BTK1.23737433
31HIPK21.17193583
32ZAP701.15943512
33CLK11.15720313
34GRK51.09136358
35CSK1.08367796
36TYK21.06551308
37TAOK31.04850915
38MAP3K101.02220993
39MAP3K61.01757057
40ERN11.00806538
41LYN0.98429817
42TRPM70.96646191
43TEC0.95088505
44KSR20.94830465
45HCK0.94493312
46SGK2230.92572559
47SGK4940.92572559
48JAK20.91759567
49KSR10.89675323
50CAMK1G0.87663711
51JAK30.86498717
52PIK3CG0.86205307
53MAP2K40.85565069
54STK110.85244479
55RPS6KA50.82144871
56TXK0.78664451
57IKBKB0.78454323
58RAF10.75427463
59TBK10.72541240
60CDK120.72074249
61PLK20.71496685
62YES10.69167212
63RPS6KC10.68125321
64RPS6KL10.68125321
65MATK0.67347719
66SGK10.66939528
67MARK20.66588962
68PRKAA20.66168820
69PLK30.64653750
70RPS6KA60.59442093
71MAP3K20.57755516
72DYRK1B0.54626501
73ITK0.53970970
74CDK40.51852260
75LCK0.50834209
76MAP2K10.50290088
77DYRK1A0.49983166
78CAMK40.48611948
79CHUK0.48386979
80MAP3K130.47713953
81CDK60.43736277
82ERBB20.42891029
83MAP3K140.39539966
84TRIB30.38343829
85KIT0.37716928
86FGFR30.36674850
87MAPK110.36067097
88SIK30.35931244
89PRKCQ0.33618850
90IRAK10.32274364
91MAP3K80.31634982
92IRAK20.31290191
93PDK10.31114622
94RPS6KA20.29949290
95MAPKAPK20.29387726
96JAK10.29295295
97AKT10.28399076
98LRRK20.28317682
99MAP3K70.27617558
100PRKD20.27201792

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.88412384
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.62582381
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.83156863
4African trypanosomiasis_Homo sapiens_hsa051432.46399566
5Non-small cell lung cancer_Homo sapiens_hsa052232.41476608
6Osteoclast differentiation_Homo sapiens_hsa043802.09687505
7Pancreatic cancer_Homo sapiens_hsa052122.02852411
8Leishmaniasis_Homo sapiens_hsa051401.99994750
9Regulation of autophagy_Homo sapiens_hsa041401.95046269
10B cell receptor signaling pathway_Homo sapiens_hsa046621.94541999
11Acute myeloid leukemia_Homo sapiens_hsa052211.93484936
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82901841
13Chronic myeloid leukemia_Homo sapiens_hsa052201.82314553
14Hematopoietic cell lineage_Homo sapiens_hsa046401.68940521
15Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.65898231
16Tuberculosis_Homo sapiens_hsa051521.60941152
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59519552
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.57307194
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55871025
20FoxO signaling pathway_Homo sapiens_hsa040681.51914854
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49995020
22Measles_Homo sapiens_hsa051621.49945271
23Hepatitis B_Homo sapiens_hsa051611.41729453
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40134661
25T cell receptor signaling pathway_Homo sapiens_hsa046601.33795180
26Influenza A_Homo sapiens_hsa051641.31480038
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.30798236
28Renal cell carcinoma_Homo sapiens_hsa052111.29248197
29Staphylococcus aureus infection_Homo sapiens_hsa051501.27502536
30Endometrial cancer_Homo sapiens_hsa052131.24408176
31Collecting duct acid secretion_Homo sapiens_hsa049661.23576146
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23163785
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.22514589
34Toxoplasmosis_Homo sapiens_hsa051451.17666863
35Apoptosis_Homo sapiens_hsa042101.17598505
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17586179
37Chemokine signaling pathway_Homo sapiens_hsa040621.14824190
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14263329
39Primary immunodeficiency_Homo sapiens_hsa053401.12270095
40Platelet activation_Homo sapiens_hsa046111.10592929
41mTOR signaling pathway_Homo sapiens_hsa041501.08394406
42Asthma_Homo sapiens_hsa053101.08141224
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05674011
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05450051
45Prolactin signaling pathway_Homo sapiens_hsa049171.03992729
46TNF signaling pathway_Homo sapiens_hsa046681.02889284
47* Herpes simplex infection_Homo sapiens_hsa051681.02793965
48Nitrogen metabolism_Homo sapiens_hsa009100.97477827
49Glioma_Homo sapiens_hsa052140.96605711
50Prostate cancer_Homo sapiens_hsa052150.95492726
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.94003133
52Dorso-ventral axis formation_Homo sapiens_hsa043200.93479209
53* Hepatitis C_Homo sapiens_hsa051600.91664811
54HIF-1 signaling pathway_Homo sapiens_hsa040660.90195617
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.88066556
56Small cell lung cancer_Homo sapiens_hsa052220.87817962
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87806946
58Bladder cancer_Homo sapiens_hsa052190.87200670
59Inositol phosphate metabolism_Homo sapiens_hsa005620.87185599
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87048241
61VEGF signaling pathway_Homo sapiens_hsa043700.86785339
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83688564
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.79266760
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78940507
65AMPK signaling pathway_Homo sapiens_hsa041520.78553217
66Phagosome_Homo sapiens_hsa041450.76563197
67Thyroid cancer_Homo sapiens_hsa052160.75713384
68Viral carcinogenesis_Homo sapiens_hsa052030.74614647
69Legionellosis_Homo sapiens_hsa051340.74415330
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72864218
71Notch signaling pathway_Homo sapiens_hsa043300.72117539
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71460522
73Choline metabolism in cancer_Homo sapiens_hsa052310.69100783
74Graft-versus-host disease_Homo sapiens_hsa053320.68066201
75HTLV-I infection_Homo sapiens_hsa051660.66743032
76Cell cycle_Homo sapiens_hsa041100.66243058
77Type II diabetes mellitus_Homo sapiens_hsa049300.64682292
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63511059
79Allograft rejection_Homo sapiens_hsa053300.63071346
80Epstein-Barr virus infection_Homo sapiens_hsa051690.61347730
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61234677
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60591072
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59096414
84Autoimmune thyroid disease_Homo sapiens_hsa053200.56939660
85Insulin resistance_Homo sapiens_hsa049310.52613683
86ABC transporters_Homo sapiens_hsa020100.52152833
87GnRH signaling pathway_Homo sapiens_hsa049120.52005558
88MicroRNAs in cancer_Homo sapiens_hsa052060.51294979
89Colorectal cancer_Homo sapiens_hsa052100.50910532
90ErbB signaling pathway_Homo sapiens_hsa040120.50625334
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.50416821
92Melanoma_Homo sapiens_hsa052180.48514583
93Endocytosis_Homo sapiens_hsa041440.46576793
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44496258
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.42467092
96MAPK signaling pathway_Homo sapiens_hsa040100.42222697
97Long-term potentiation_Homo sapiens_hsa047200.42205784
98Systemic lupus erythematosus_Homo sapiens_hsa053220.39835947
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.39409402
100p53 signaling pathway_Homo sapiens_hsa041150.38924697

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