IFI44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.64844432
2response to interferon-alpha (GO:0035455)7.12738437
3cellular response to type I interferon (GO:0071357)6.76267632
4type I interferon signaling pathway (GO:0060337)6.76267632
5response to type I interferon (GO:0034340)6.73583015
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.69505180
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.69505180
8antigen processing and presentation of endogenous antigen (GO:0019883)6.03486648
9response to interferon-beta (GO:0035456)5.77199863
10positive regulation of interferon-alpha production (GO:0032727)5.66138097
11regulation of interferon-alpha production (GO:0032647)5.30191328
12regulation of RIG-I signaling pathway (GO:0039535)5.28792286
13negative regulation of viral genome replication (GO:0045071)5.21438466
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.03308570
15interferon-gamma-mediated signaling pathway (GO:0060333)4.70659011
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.69360385
17negative regulation of cell killing (GO:0031342)4.69360385
18antigen processing and presentation via MHC class Ib (GO:0002475)4.59093664
19immunoglobulin mediated immune response (GO:0016064)4.58516666
20regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.57183329
21negative regulation of interleukin-12 production (GO:0032695)4.41471845
22T-helper 1 type immune response (GO:0042088)4.41203426
23cellular response to interferon-alpha (GO:0035457)4.27317736
24positive regulation of natural killer cell differentiation (GO:0032825)4.26025548
25cellular response to interferon-beta (GO:0035458)4.09505842
26macrophage activation involved in immune response (GO:0002281)4.09438293
27cellular response to virus (GO:0098586)3.98041463
28regulation of T-helper 1 cell differentiation (GO:0045625)3.97094779
29cellular response to exogenous dsRNA (GO:0071360)3.93649118
30defense response to protozoan (GO:0042832)3.88452570
31regulation of interferon-beta biosynthetic process (GO:0045357)3.77965225
32regulation of type I interferon-mediated signaling pathway (GO:0060338)3.71879830
33detection of bacterium (GO:0016045)3.71825548
34B cell mediated immunity (GO:0019724)3.70045161
35positive regulation of interferon-beta production (GO:0032728)3.69250508
36defense response to virus (GO:0051607)3.66534421
37cellular response to interferon-gamma (GO:0071346)3.62608557
38response to interferon-gamma (GO:0034341)3.62577890
39negative regulation of T cell mediated immunity (GO:0002710)3.58950873
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56274743
41regulation of gamma-delta T cell activation (GO:0046643)3.55970079
42T cell migration (GO:0072678)3.51827164
43negative regulation of cytokine production involved in immune response (GO:0002719)3.51584150
44response to protozoan (GO:0001562)3.49790968
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.45610336
46positive regulation of gamma-delta T cell activation (GO:0046645)3.45075606
47positive regulation by symbiont of host defense response (GO:0052509)3.43101619
48modulation by symbiont of host defense response (GO:0052031)3.43101619
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43101619
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43101619
51positive regulation by organism of defense response of other organism involved in symbiotic interact3.43101619
52modulation by symbiont of host immune response (GO:0052553)3.43101619
53regulation of natural killer cell differentiation (GO:0032823)3.39399042
54germinal center formation (GO:0002467)3.37313482
55positive regulation of antigen processing and presentation (GO:0002579)3.35241439
56definitive hemopoiesis (GO:0060216)3.35217637
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.34734844
58positive regulation of cAMP-mediated signaling (GO:0043950)3.34566652
59detection of external biotic stimulus (GO:0098581)3.34086975
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33628394
61regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.32122251
62production of molecular mediator involved in inflammatory response (GO:0002532)3.28080069
63neutrophil activation involved in immune response (GO:0002283)3.21539847
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20088060
65response to peptidoglycan (GO:0032494)3.20067743
66mature B cell differentiation involved in immune response (GO:0002313)3.19997441
67regulation of viral genome replication (GO:0045069)3.19041552
68regulation of type 2 immune response (GO:0002828)3.18833833
69negative regulation of lymphocyte mediated immunity (GO:0002707)3.18186473
70necroptotic process (GO:0070266)3.17951524
71positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17569331
72myeloid dendritic cell activation (GO:0001773)3.17207744
73myeloid dendritic cell differentiation (GO:0043011)3.15602404
74regulation of T cell tolerance induction (GO:0002664)3.10823477
75positive regulation of B cell differentiation (GO:0045579)3.08896742
76natural killer cell mediated cytotoxicity (GO:0042267)3.08257630
77natural killer cell mediated immunity (GO:0002228)3.08257630
78detection of other organism (GO:0098543)3.05692841
79cellular response to thyroid hormone stimulus (GO:0097067)3.05443970
80positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05411303
81microglial cell activation (GO:0001774)3.04951454
82positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.03254288
83leukocyte aggregation (GO:0070486)3.02255879
84negative regulation of viral process (GO:0048525)3.01808948
85negative regulation of interleukin-17 production (GO:0032700)3.00452708
86negative regulation of myeloid cell apoptotic process (GO:0033033)2.99173027
87regulation of defense response to virus by host (GO:0050691)2.98798136
88regulation of vitamin D biosynthetic process (GO:0060556)2.98002561
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97679923
90regulation of natural killer cell activation (GO:0032814)2.97128643
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96595596
92response to host immune response (GO:0052572)2.96595596
93negative regulation of innate immune response (GO:0045824)2.96473602
94regulation of antigen processing and presentation (GO:0002577)2.95050310
95regulation of interferon-beta production (GO:0032648)2.94234939
96dendritic cell differentiation (GO:0097028)2.93720733
97detection of biotic stimulus (GO:0009595)2.93647738
98positive regulation of natural killer cell activation (GO:0032816)2.93575732
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93114421
100myeloid cell activation involved in immune response (GO:0002275)2.93090053
101regulation of tolerance induction (GO:0002643)2.93073049
102interferon-gamma secretion (GO:0072643)2.92826397
103negative regulation of leukocyte mediated immunity (GO:0002704)2.91468910
104NIK/NF-kappaB signaling (GO:0038061)2.91458381
105mature B cell differentiation (GO:0002335)2.91050827
106positive regulation of defense response to virus by host (GO:0002230)2.90919696
107negative regulation of viral entry into host cell (GO:0046597)2.90481388
108negative regulation of production of molecular mediator of immune response (GO:0002701)2.89115372
109lymphocyte chemotaxis (GO:0048247)2.87217335
110regulation of interleukin-12 production (GO:0032655)2.87099057
111positive regulation of response to biotic stimulus (GO:0002833)2.86390758
112regulation of necroptotic process (GO:0060544)2.85050852
113granulocyte activation (GO:0036230)2.83400562
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83388116
115response to muramyl dipeptide (GO:0032495)2.83359621
116macrophage activation (GO:0042116)2.82393226
117regulation of B cell receptor signaling pathway (GO:0050855)2.82356517
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82058854
119positive regulation of type 2 immune response (GO:0002830)2.79853581
120regulation of alpha-beta T cell proliferation (GO:0046640)2.79657313
121cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.79338550
122negative regulation of nitric oxide biosynthetic process (GO:0045019)2.77672231
123negative regulation of type I interferon production (GO:0032480)2.77533395
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77166203
125positive regulation of interleukin-12 production (GO:0032735)2.76997452
126response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.74741296
127response to host (GO:0075136)2.74741296
128response to host defenses (GO:0052200)2.74741296
129regulation of T cell mediated cytotoxicity (GO:0001914)2.74345631
130regulation of response to interferon-gamma (GO:0060330)2.73075233
131regulation of activation of Janus kinase activity (GO:0010533)2.73063714
132positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.73040338
133negative regulation of erythrocyte differentiation (GO:0045647)2.71747393
134detection of molecule of bacterial origin (GO:0032490)2.69280233
135programmed necrotic cell death (GO:0097300)2.68896998
136regulation of B cell differentiation (GO:0045577)2.68805774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.75438012
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.59556236
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.44725572
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.74801796
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.40837117
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10571871
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.81375491
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42446997
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19340804
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14005784
11SCL_19346495_ChIP-Seq_HPC-7_Human3.01185866
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90200027
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88335014
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82666432
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74552749
16GATA1_22025678_ChIP-Seq_K562_Human2.69528725
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61243261
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58197905
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.36039168
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29535465
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28615438
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.18609560
23SPI1_23547873_ChIP-Seq_NB4_Human2.04207299
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01496261
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84697843
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83508022
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81515168
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78491896
29RUNX_20019798_ChIP-Seq_JUKART_Human1.75604071
30MYB_26560356_Chip-Seq_TH2_Human1.74598715
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74581617
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.68268086
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65892376
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65547315
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.54761931
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54635171
37* MAF_26560356_Chip-Seq_TH1_Human1.53623391
38MYB_26560356_Chip-Seq_TH1_Human1.48719140
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48308979
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48288219
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45110053
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.44997541
43PU_27001747_Chip-Seq_BMDM_Mouse1.44676745
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43892143
45VDR_24763502_ChIP-Seq_THP-1_Human1.39058113
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.35819205
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35579957
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.34872153
49MYC_22102868_ChIP-Seq_BL_Human1.33624201
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30507676
51SPI1_23127762_ChIP-Seq_K562_Human1.28549905
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28131374
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23497440
54GATA3_26560356_Chip-Seq_TH2_Human1.20791102
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16836552
56VDR_24787735_ChIP-Seq_THP-1_Human1.14357630
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12074668
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09738945
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09646591
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09414005
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09179793
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08282623
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04613938
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04195507
65GATA3_27048872_Chip-Seq_THYMUS_Human1.02629555
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01756330
67* SOX2_20726797_ChIP-Seq_SW620_Human1.00797129
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00233450
69EGR1_19032775_ChIP-ChIP_M12_Human0.98932930
70HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98265755
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97835083
72VDR_21846776_ChIP-Seq_THP-1_Human0.97608633
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97222259
74KDM2B_26808549_Chip-Seq_DND41_Human0.97097032
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95274448
76ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93823105
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92559997
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92540886
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91502123
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90629197
81GATA1_19941827_ChIP-Seq_MEL_Mouse0.90130171
82UTX_26944678_Chip-Seq_JUKART_Human0.86060692
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85716178
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82825474
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82750094
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.82324499
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82258776
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80784696
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76193686
90TCF7_22412390_ChIP-Seq_EML_Mouse0.76025511
91SMRT_27268052_Chip-Seq_Bcells_Human0.74075475
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73943692
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73231886
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73028604
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.72446519
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71972044
97* MAF_26560356_Chip-Seq_TH2_Human0.71892668
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.71825647
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69668453
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.69426933
101* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68886032
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66843284
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66090794
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65382964
105BCL6_27268052_Chip-Seq_Bcells_Human0.64313941
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.60761801
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.60761801
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60486972
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60273224
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.59124201
111STAT1_20625510_ChIP-Seq_HELA_Human0.58437519
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57235126
113GATA2_19941826_ChIP-Seq_K562_Human0.56984520
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.56830692
115SRF_21415370_ChIP-Seq_HL-1_Mouse0.56815312
116GATA1_19941826_ChIP-Seq_K562_Human0.56192946
117TFEB_21752829_ChIP-Seq_HELA_Human0.55404675
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54390517
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.53682602
120BCOR_27268052_Chip-Seq_Bcells_Human0.51917655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.09021342
2MP0009785_altered_susceptibility_to4.45651513
3MP0003724_increased_susceptibility_to4.17173915
4MP0000685_abnormal_immune_system3.40459512
5MP0002148_abnormal_hypersensitivity_rea3.22472687
6MP0005671_abnormal_response_to3.19736444
7MP0005025_abnormal_response_to3.11463009
8MP0001790_abnormal_immune_system2.78466011
9MP0005387_immune_system_phenotype2.78466011
10MP0005000_abnormal_immune_tolerance2.66396412
11MP0001800_abnormal_humoral_immune2.60416825
12MP0002419_abnormal_innate_immunity2.54940081
13MP0002723_abnormal_immune_serum2.51638081
14MP0002452_abnormal_antigen_presenting2.51193452
15MP0003436_decreased_susceptibility_to2.46382329
16MP0006082_CNS_inflammation2.40834420
17MP0005464_abnormal_platelet_physiology2.27053978
18MP0001819_abnormal_immune_cell2.24749027
19MP0002396_abnormal_hematopoietic_system2.21484987
20MP0002420_abnormal_adaptive_immunity2.20863444
21MP0005397_hematopoietic_system_phenotyp2.13225135
22MP0001545_abnormal_hematopoietic_system2.13225135
23MP0004510_myositis2.08330865
24MP0002166_altered_tumor_susceptibility2.02319176
25MP0010155_abnormal_intestine_physiology2.00009065
26MP0001853_heart_inflammation1.95523474
27MP0009764_decreased_sensitivity_to1.82409090
28MP0009278_abnormal_bone_marrow1.82055095
29MP0002398_abnormal_bone_marrow1.81513026
30MP0001845_abnormal_inflammatory_respons1.78971679
31MP0004947_skin_inflammation1.77662152
32MP0004808_abnormal_hematopoietic_stem1.77069584
33MP0008469_abnormal_protein_level1.76893446
34MP0000716_abnormal_immune_system1.74167110
35MP0001533_abnormal_skeleton_physiology1.68365597
36MP0002006_tumorigenesis1.66576819
37MP0005451_abnormal_body_composition1.66065796
38MP0001879_abnormal_lymphatic_vessel1.63542234
39MP0000343_altered_response_to1.61697998
40MP0002405_respiratory_system_inflammati1.57381150
41MP0005058_abnormal_lysosome_morphology1.55205305
42MP0000689_abnormal_spleen_morphology1.48377242
43MP0002429_abnormal_blood_cell1.48270805
44MP0003763_abnormal_thymus_physiology1.42470963
45MP0004782_abnormal_surfactant_physiolog1.41196218
46MP0002722_abnormal_immune_system1.38556369
47MP0002277_abnormal_respiratory_mucosa1.38128537
48MP0009333_abnormal_splenocyte_physiolog1.35150541
49MP0003191_abnormal_cellular_cholesterol1.34861212
50MP0002332_abnormal_exercise_endurance1.31514515
51MP0005174_abnormal_tail_pigmentation1.30800407
52MP0003448_altered_tumor_morphology1.28029241
53MP0003186_abnormal_redox_activity1.26487053
54MP0005167_abnormal_blood-brain_barrier1.25650434
55MP0003828_pulmonary_edema1.23223913
56MP0006054_spinal_hemorrhage1.22924915
57MP0003303_peritoneal_inflammation1.18996270
58MP0005310_abnormal_salivary_gland1.15390340
59MP0003075_altered_response_to1.14998078
60MP0010368_abnormal_lymphatic_system1.14128696
61MP0001873_stomach_inflammation1.13764315
62MP0000465_gastrointestinal_hemorrhage1.13332950
63MP0002254_reproductive_system_inflammat1.08965738
64MP0003690_abnormal_glial_cell1.08558086
65MP0004883_abnormal_blood_vessel1.05876182
66MP0003943_abnormal_hepatobiliary_system1.00519885
67MP0001851_eye_inflammation0.99508172
68MP0003806_abnormal_nucleotide_metabolis0.97859917
69MP0009763_increased_sensitivity_to0.97342800
70MP0005390_skeleton_phenotype0.96170894
71MP0000858_altered_metastatic_potential0.95921520
72MP0002933_joint_inflammation0.95916255
73MP0000604_amyloidosis0.95761335
74MP0002998_abnormal_bone_remodeling0.95350378
75MP0005164_abnormal_response_to0.95335678
76MP0008260_abnormal_autophagy0.94517929
77MP0003172_abnormal_lysosome_physiology0.93369230
78MP0000249_abnormal_blood_vessel0.91590542
79MP0004147_increased_porphyrin_level0.91590282
80MP0003300_gastrointestinal_ulcer0.90123507
81MP0003183_abnormal_peptide_metabolism0.88369805
82MP0005075_abnormal_melanosome_morpholog0.87758737
83MP0002095_abnormal_skin_pigmentation0.87068629
84MP0000767_abnormal_smooth_muscle0.84562005
85MP0000490_abnormal_crypts_of0.83970050
86MP0000703_abnormal_thymus_morphology0.83780360
87MP0009840_abnormal_foam_cell0.82233563
88MP0003866_abnormal_defecation0.81644524
89MP0001958_emphysema0.79445495
90MP0000681_abnormal_thyroid_gland0.78357137
91MP0002139_abnormal_hepatobiliary_system0.78318201
92MP0003091_abnormal_cell_migration0.77133898
93MP0003221_abnormal_cardiomyocyte_apopto0.74571161
94MP0001663_abnormal_digestive_system0.73404229
95MP0009697_abnormal_copulation0.70933980
96MP0008874_decreased_physiological_sensi0.70933323
97MP0003045_fibrosis0.69917501
98MP0005166_decreased_susceptibility_to0.67088847
99MP0003795_abnormal_bone_structure0.66685518
100MP0003453_abnormal_keratinocyte_physiol0.65631059
101MP0003566_abnormal_cell_adhesion0.65286419
102MP0000015_abnormal_ear_pigmentation0.63960075
103MP0005023_abnormal_wound_healing0.63459602
104MP0003195_calcinosis0.63364633
105MP0002138_abnormal_hepatobiliary_system0.63262555
106MP0001542_abnormal_bone_strength0.62683753
107MP0002132_abnormal_respiratory_system0.61716419
108MP0010307_abnormal_tumor_latency0.61075020
109MP0009765_abnormal_xenobiotic_induced0.59478183
110MP0005165_increased_susceptibility_to0.58993899
111MP0005319_abnormal_enzyme/_coenzyme0.57428516
112MP0001191_abnormal_skin_condition0.56655633
113MP0002877_abnormal_melanocyte_morpholog0.56618342
114MP0000920_abnormal_myelination0.56569691
115MP0008004_abnormal_stomach_pH0.54494370
116MP0003656_abnormal_erythrocyte_physiolo0.53597570
117MP0008007_abnormal_cellular_replicative0.53196984
118MP0002136_abnormal_kidney_physiology0.52017058
119MP0005535_abnormal_body_temperature0.50737128
120MP0000609_abnormal_liver_physiology0.49959060
121MP0002019_abnormal_tumor_incidence0.49014053

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.53763942
2Elevated erythrocyte sedimentation rate (HP:0003565)5.27943671
3Recurrent abscess formation (HP:0002722)5.07202879
4Myositis (HP:0100614)4.97606230
5Eczematoid dermatitis (HP:0000976)4.55636539
6Recurrent bacterial skin infections (HP:0005406)4.50968495
7Autoimmune thrombocytopenia (HP:0001973)4.47131733
8Abnormality of the nasal mucosa (HP:0000433)4.08270218
9Thrombocytosis (HP:0001894)4.07263343
10Increased IgM level (HP:0003496)3.91516432
11Gastrointestinal infarctions (HP:0005244)3.86529316
12Abnormality of macrophages (HP:0004311)3.79188818
13Orchitis (HP:0100796)3.64487508
14Recurrent bronchitis (HP:0002837)3.63286093
15Interstitial pulmonary disease (HP:0006530)3.57614553
16Nasal polyposis (HP:0100582)3.51087768
17T lymphocytopenia (HP:0005403)3.46467459
18Abnormality of T cell number (HP:0011839)3.45970497
19Autoimmune hemolytic anemia (HP:0001890)3.45691639
20Recurrent skin infections (HP:0001581)3.34939953
21Vacuolated lymphocytes (HP:0001922)3.31417253
22Recurrent viral infections (HP:0004429)3.30522174
23Optic neuritis (HP:0100653)3.30327022
24Retrobulbar optic neuritis (HP:0100654)3.30327022
25Recurrent fungal infections (HP:0002841)3.29592644
26Abnormality of liposaccharide metabolism (HP:0010968)3.26146581
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.26146581
28Abnormality of glycolipid metabolism (HP:0010969)3.26146581
29Recurrent gram-negative bacterial infections (HP:0005420)3.25549125
30Vasculitis (HP:0002633)3.23940642
31Spontaneous hematomas (HP:0007420)3.23591892
32Hypergammaglobulinemia (HP:0010702)3.17922770
33Tetraparesis (HP:0002273)3.08248540
34Basal ganglia calcification (HP:0002135)3.06995255
35Hematochezia (HP:0002573)3.06781516
36Petechiae (HP:0000967)3.04152122
37Gangrene (HP:0100758)3.01878768
38Chronic sinusitis (HP:0011109)3.00898957
39Prolonged bleeding time (HP:0003010)3.00706427
40Recurrent cutaneous fungal infections (HP:0011370)2.99362029
41Chronic mucocutaneous candidiasis (HP:0002728)2.99362029
42Mediastinal lymphadenopathy (HP:0100721)2.92764715
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.91820966
44Increased cerebral lipofuscin (HP:0011813)2.80513722
45Arterial thrombosis (HP:0004420)2.79529950
46IgM deficiency (HP:0002850)2.72165519
47Abnormality of the pleura (HP:0002103)2.72134350
48Colitis (HP:0002583)2.70294078
49Cellulitis (HP:0100658)2.68194536
50Gingival bleeding (HP:0000225)2.67918262
51Pulmonary embolism (HP:0002204)2.67839784
52Anorexia (HP:0002039)2.66938352
53Epistaxis (HP:0000421)2.65559059
54Prostate neoplasm (HP:0100787)2.64272370
55Chronic diarrhea (HP:0002028)2.59719464
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.59648182
57Inflammation of the large intestine (HP:0002037)2.56425953
58Periodontitis (HP:0000704)2.56007705
59Pustule (HP:0200039)2.55835900
60Abnormality of T cell physiology (HP:0011840)2.55422890
61Panhypogammaglobulinemia (HP:0003139)2.52685787
62Disinhibition (HP:0000734)2.52307768
63IgG deficiency (HP:0004315)2.51005882
64Stomatitis (HP:0010280)2.50329602
65Systemic lupus erythematosus (HP:0002725)2.46525633
66Hemoptysis (HP:0002105)2.43435329
67Gastrointestinal inflammation (HP:0004386)2.39234797
68Purpura (HP:0000979)2.39198378
69Gingivitis (HP:0000230)2.37851327
70Meningitis (HP:0001287)2.37796627
71Thick nail (HP:0001805)2.37133764
72Peritonitis (HP:0002586)2.34680396
73Granulocytopenia (HP:0001913)2.33910710
74Porencephaly (HP:0002132)2.33790079
75Joint swelling (HP:0001386)2.33070087
76Polyneuropathy (HP:0001271)2.32150342
77Loss of speech (HP:0002371)2.30583035
78Abnormality of the endocardium (HP:0004306)2.30477407
79IgA deficiency (HP:0002720)2.29811388
80Abnormality of the pericardium (HP:0001697)2.29503100
81Abnormality of B cell number (HP:0010975)2.28877120
82Abnormality of T cells (HP:0002843)2.26471967
83Agammaglobulinemia (HP:0004432)2.26358232
84Dysostosis multiplex (HP:0000943)2.24392331
85Glomerulopathy (HP:0100820)2.24372811
86Acute myeloid leukemia (HP:0004808)2.23166907
87Obstructive lung disease (HP:0006536)2.21586170
88Chronic obstructive pulmonary disease (HP:0006510)2.21586170
89Increased IgE level (HP:0003212)2.20693891
90Aplastic anemia (HP:0001915)2.20024378
91Encephalitis (HP:0002383)2.19775136
92Pulmonary infiltrates (HP:0002113)2.19769626
93Emphysema (HP:0002097)2.17041296
94Vertebral compression fractures (HP:0002953)2.16568464
95Leukocytosis (HP:0001974)2.15873001
96Erythema (HP:0010783)2.14594753
97Recurrent lower respiratory tract infections (HP:0002783)2.14408661
98Keratitis (HP:0000491)2.14018534
99Amyloidosis (HP:0011034)2.12626109
100Thyroiditis (HP:0100646)2.12611667
101Vertigo (HP:0002321)2.11940883
102Eosinophilia (HP:0001880)2.10124010
103Gastrointestinal stroma tumor (HP:0100723)2.09706322
104Abnormality of the peritoneum (HP:0002585)2.08696157
105Chest pain (HP:0100749)2.08638805
106Arthralgia (HP:0002829)2.07988981
107Abnormality of eosinophils (HP:0001879)2.07600237
108Osteomyelitis (HP:0002754)2.05821099
109Lymphopenia (HP:0001888)2.05485940
110Urticaria (HP:0001025)2.04798580
111Abnormality of the prostate (HP:0008775)2.04162265
112Recurrent pneumonia (HP:0006532)2.03787552
113B lymphocytopenia (HP:0010976)2.03589952
114Keratoconjunctivitis sicca (HP:0001097)2.02826756
115Abnormality of cells of the lymphoid lineage (HP:0012140)2.02146421
116Portal hypertension (HP:0001409)2.02004846
117Restrictive lung disease (HP:0002091)2.00586816
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98402707
119Cheilitis (HP:0100825)1.97967577
120Bronchitis (HP:0012387)1.97142005
121Thrombophlebitis (HP:0004418)1.96815861
122Microcytic anemia (HP:0001935)1.96073039
123Beaking of vertebral bodies (HP:0004568)1.95277666
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94019028
125Skin ulcer (HP:0200042)1.91204177
126Esophageal varix (HP:0002040)1.91033270
127Abnormality of the hepatic vasculature (HP:0006707)1.90331369
128Amaurosis fugax (HP:0100576)1.90030608
129Exertional dyspnea (HP:0002875)1.89742270
130Keratoconjunctivitis (HP:0001096)1.87824958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT4.73570281
2IKBKE3.87988756
3TBK13.79346988
4TYK23.32303460
5JAK33.08926595
6IRAK42.83717996
7MAP3K142.80262332
8ADRBK22.74939688
9TIE12.73118355
10FLT32.68896976
11NME22.67236282
12TGFBR12.40362215
13MAP4K12.35865853
14PRPF4B2.27142071
15TGFBR22.26565883
16CSF1R2.16015472
17IKBKB2.14700774
18TEC2.07911017
19FGFR41.99579946
20PIM21.90116854
21GRK71.90115205
22JAK11.85691204
23RIPK41.83527189
24MAP3K131.77390631
25IRAK31.67919480
26BTK1.52618344
27BLK1.52445795
28TXK1.50491701
29RPS6KA41.44727570
30PBK1.42537447
31FGFR31.33036834
32TAOK21.32092744
33MATK1.29766069
34SYK1.27310494
35MAP2K31.23766056
36KDR1.23136369
37TNK21.19812503
38TAOK31.19410157
39NLK1.19144904
40ZAP701.13448282
41TNIK1.12591226
42CHUK1.11732674
43FES1.11641359
44LCK1.08325915
45TAOK11.04508053
46SIK31.03050141
47LYN0.97566715
48EPHB10.90422597
49IRAK10.89807196
50EPHA30.87909559
51DDR20.87026087
52EIF2AK20.86527095
53MAP3K60.84542485
54HCK0.80191575
55BMPR20.79595066
56GRK60.79542391
57PIM10.78710765
58MAP3K110.78640948
59DAPK20.76571153
60TRPM70.74942375
61CSK0.71903004
62PRKG20.71902146
63ARAF0.71805744
64SIK20.70561253
65ERN10.69610720
66MAPK70.69374364
67RIPK10.68739212
68CDC42BPA0.67693948
69BMPR1B0.66628667
70MAP3K10.66233648
71MAPK110.65943954
72MAP3K50.62875917
73CLK10.59078996
74YES10.58575860
75BRSK20.57274278
76ACVR1B0.57123443
77NEK90.56554629
78CDK80.56254806
79MUSK0.56198167
80MST40.53948037
81MAPKAPK50.50413260
82RPS6KA50.49762198
83PDK10.48214240
84MYLK0.48163697
85MAP3K120.48151467
86MAP2K60.46729459
87PRKCD0.45621652
88FYN0.44853395
89RPS6KB20.44056617
90ABL10.42158189
91JAK20.42076016
92LRRK20.39089162
93PRKD20.38834464
94EGFR0.37851382
95RPS6KC10.37469414
96RPS6KL10.37469414
97EEF2K0.36881752
98ITK0.33781310
99NUAK10.33350996
100PRKCQ0.32685612
101MAP3K30.30916841
102RPS6KA60.30598263
103PTK60.30548017
104ABL20.30146187
105IGF1R0.29763745
106TESK20.28356287
107HIPK20.28030430
108ERBB30.27235225
109PAK40.27208604
110CAMKK20.26698513
111MAPKAPK20.25592190
112CDK60.25242041
113BMX0.25126694
114MARK30.24986013
115MOS0.24834182
116FGR0.24741348
117IRAK20.24038582
118CCNB10.23483696
119STK100.23143822
120STK160.23036925
121PDPK10.22945456
122PIK3CG0.22528301
123CDK40.22312483
124MAPK120.22123535
125INSR0.21985165
126MAPK40.21269944
127VRK10.21053648
128PRKCH0.19294503
129MAPK30.17965654

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.54868660
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.47264876
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.10759753
4Leishmaniasis_Homo sapiens_hsa051402.94727953
5Allograft rejection_Homo sapiens_hsa053302.87286222
6Measles_Homo sapiens_hsa051622.78465687
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.63431023
8Influenza A_Homo sapiens_hsa051642.35262714
9Staphylococcus aureus infection_Homo sapiens_hsa051502.33567896
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.33205023
11Herpes simplex infection_Homo sapiens_hsa051682.32726775
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31834153
13Malaria_Homo sapiens_hsa051442.20147620
14Primary immunodeficiency_Homo sapiens_hsa053402.13294012
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08580915
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.95145039
17Graft-versus-host disease_Homo sapiens_hsa053321.94708173
18Pertussis_Homo sapiens_hsa051331.94161643
19Antigen processing and presentation_Homo sapiens_hsa046121.93203374
20Legionellosis_Homo sapiens_hsa051341.92884907
21TNF signaling pathway_Homo sapiens_hsa046681.88897210
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.83004866
23Osteoclast differentiation_Homo sapiens_hsa043801.82573452
24African trypanosomiasis_Homo sapiens_hsa051431.79572759
25Hematopoietic cell lineage_Homo sapiens_hsa046401.73621694
26Toxoplasmosis_Homo sapiens_hsa051451.71158762
27Asthma_Homo sapiens_hsa053101.68118058
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62994699
29Hepatitis C_Homo sapiens_hsa051601.50125583
30Rheumatoid arthritis_Homo sapiens_hsa053231.50033948
31B cell receptor signaling pathway_Homo sapiens_hsa046621.47244916
32Tuberculosis_Homo sapiens_hsa051521.46523954
33Type I diabetes mellitus_Homo sapiens_hsa049401.44066607
34Shigellosis_Homo sapiens_hsa051311.35923531
35Autoimmune thyroid disease_Homo sapiens_hsa053201.27964121
36Hepatitis B_Homo sapiens_hsa051611.24901392
37Salmonella infection_Homo sapiens_hsa051321.23866659
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20899403
39Apoptosis_Homo sapiens_hsa042101.19933270
40Chemokine signaling pathway_Homo sapiens_hsa040621.19256980
41Caffeine metabolism_Homo sapiens_hsa002321.17127350
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12205691
43Viral myocarditis_Homo sapiens_hsa054161.11918680
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11050649
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09011047
46Acute myeloid leukemia_Homo sapiens_hsa052210.98594183
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98276884
48Other glycan degradation_Homo sapiens_hsa005110.97361583
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92996874
50Platelet activation_Homo sapiens_hsa046110.91653550
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.89834698
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.89145309
53Lysosome_Homo sapiens_hsa041420.87650138
54Phagosome_Homo sapiens_hsa041450.80008019
55Ribosome_Homo sapiens_hsa030100.79426516
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75083650
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71664210
58Small cell lung cancer_Homo sapiens_hsa052220.67765866
59Notch signaling pathway_Homo sapiens_hsa043300.64857557
60Prolactin signaling pathway_Homo sapiens_hsa049170.60491813
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59944624
62Systemic lupus erythematosus_Homo sapiens_hsa053220.58608300
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57539618
64Amoebiasis_Homo sapiens_hsa051460.55708074
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54708420
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54389990
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53169762
68VEGF signaling pathway_Homo sapiens_hsa043700.52452985
69Pancreatic cancer_Homo sapiens_hsa052120.52315540
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51001593
71Complement and coagulation cascades_Homo sapiens_hsa046100.48765513
72Chronic myeloid leukemia_Homo sapiens_hsa052200.48197620
73HIF-1 signaling pathway_Homo sapiens_hsa040660.47791996
74Folate biosynthesis_Homo sapiens_hsa007900.47688488
75Epstein-Barr virus infection_Homo sapiens_hsa051690.46015527
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45281338
77Prion diseases_Homo sapiens_hsa050200.44466517
78Bladder cancer_Homo sapiens_hsa052190.43611498
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.42203438
80Viral carcinogenesis_Homo sapiens_hsa052030.41912156
81T cell receptor signaling pathway_Homo sapiens_hsa046600.41226910
82Non-small cell lung cancer_Homo sapiens_hsa052230.39236803
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37734653
84ABC transporters_Homo sapiens_hsa020100.37181645
85p53 signaling pathway_Homo sapiens_hsa041150.36029214
86Proteasome_Homo sapiens_hsa030500.35834640
87Dorso-ventral axis formation_Homo sapiens_hsa043200.35522346
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35113441
89Arachidonic acid metabolism_Homo sapiens_hsa005900.32194871
90Insulin resistance_Homo sapiens_hsa049310.32005796
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.31982706
92Type II diabetes mellitus_Homo sapiens_hsa049300.31577238
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31350140
94Endocytosis_Homo sapiens_hsa041440.30812796
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30608517
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30492742
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30097711
98FoxO signaling pathway_Homo sapiens_hsa040680.29285690
99Vitamin digestion and absorption_Homo sapiens_hsa049770.29259747
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28928792
101HTLV-I infection_Homo sapiens_hsa051660.28818637
102Peroxisome_Homo sapiens_hsa041460.27071034
103Renal cell carcinoma_Homo sapiens_hsa052110.24198926
104MAPK signaling pathway_Homo sapiens_hsa040100.22489617
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.19754819
106Galactose metabolism_Homo sapiens_hsa000520.19633514
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19541342
108Sphingolipid metabolism_Homo sapiens_hsa006000.18391352
109Base excision repair_Homo sapiens_hsa034100.18071880
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17803606
111mTOR signaling pathway_Homo sapiens_hsa041500.17782090
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17743373
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.17630052
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17478118
115Pathways in cancer_Homo sapiens_hsa052000.17423182
116Non-homologous end-joining_Homo sapiens_hsa034500.16475619
117Focal adhesion_Homo sapiens_hsa045100.14043393
118Prostate cancer_Homo sapiens_hsa052150.11350550
119Thyroid cancer_Homo sapiens_hsa052160.10842756
120GnRH signaling pathway_Homo sapiens_hsa049120.07566988
121Choline metabolism in cancer_Homo sapiens_hsa052310.06737599
122ErbB signaling pathway_Homo sapiens_hsa040120.05062364
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.01630906

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