IFI27L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.06889787
2protein neddylation (GO:0045116)5.76457612
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.61688039
4ATP synthesis coupled proton transport (GO:0015986)5.61688039
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.53875525
6protein complex biogenesis (GO:0070271)5.18229796
7respiratory electron transport chain (GO:0022904)5.16048160
8sequestering of actin monomers (GO:0042989)5.10575269
9electron transport chain (GO:0022900)5.07060280
10platelet dense granule organization (GO:0060155)4.76376022
11mitochondrial respiratory chain complex assembly (GO:0033108)4.42248315
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.23074085
13DNA deamination (GO:0045006)4.05003571
14chaperone-mediated protein transport (GO:0072321)4.03805918
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03331509
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.03331509
17NADH dehydrogenase complex assembly (GO:0010257)4.03331509
18ribosomal small subunit assembly (GO:0000028)3.98094473
19cytidine metabolic process (GO:0046087)3.97702648
20cytidine catabolic process (GO:0006216)3.97702648
21cytidine deamination (GO:0009972)3.97702648
22viral transcription (GO:0019083)3.91326080
23protein targeting to ER (GO:0045047)3.73901721
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.73896859
25cotranslational protein targeting to membrane (GO:0006613)3.71544622
26protein localization to endoplasmic reticulum (GO:0070972)3.66384943
27translational termination (GO:0006415)3.65700704
28hydrogen ion transmembrane transport (GO:1902600)3.62627026
29eosinophil chemotaxis (GO:0048245)3.58960606
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57442977
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56945205
32cytochrome complex assembly (GO:0017004)3.41271495
33proton transport (GO:0015992)3.31670617
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.31336797
35behavioral response to nicotine (GO:0035095)3.27589985
36hydrogen transport (GO:0006818)3.25201225
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22702866
38eosinophil migration (GO:0072677)3.19879541
39positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.19078387
40ATP biosynthetic process (GO:0006754)3.15770877
41translational elongation (GO:0006414)3.13895659
42positive regulation of TOR signaling (GO:0032008)3.09508803
43water-soluble vitamin biosynthetic process (GO:0042364)3.02863812
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98877230
45purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98458914
46viral life cycle (GO:0019058)2.97521057
47iron-sulfur cluster assembly (GO:0016226)2.94634388
48metallo-sulfur cluster assembly (GO:0031163)2.94634388
49ribosomal small subunit biogenesis (GO:0042274)2.87065151
50cellular response to zinc ion (GO:0071294)2.82709809
51proteasome assembly (GO:0043248)2.79856528
52protein maturation by protein folding (GO:0022417)2.78791242
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77418797
54cellular protein complex disassembly (GO:0043624)2.74854106
55regulation of cilium movement (GO:0003352)2.74715791
56deoxyribonucleotide catabolic process (GO:0009264)2.74245079
57regulation of mitochondrial translation (GO:0070129)2.73722606
58response to interferon-beta (GO:0035456)2.69535949
59negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66669071
60energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.63169369
61ATP hydrolysis coupled proton transport (GO:0015991)2.63169369
62neuron fate determination (GO:0048664)2.60703169
63negative regulation of membrane potential (GO:0045837)2.60593963
64positive regulation of T cell apoptotic process (GO:0070234)2.60538992
65cellular response to interferon-beta (GO:0035458)2.60525485
66positive regulation of lymphocyte apoptotic process (GO:0070230)2.58413119
67pyrimidine nucleotide catabolic process (GO:0006244)2.57296341
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.56124178
69termination of RNA polymerase III transcription (GO:0006386)2.56124178
70pyrimidine nucleoside catabolic process (GO:0046135)2.55827607
71respiratory chain complex IV assembly (GO:0008535)2.55041716
72response to gravity (GO:0009629)2.54616583
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54526778
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54526778
75regulation of cellular amino acid metabolic process (GO:0006521)2.54255247
76negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.53596386
77macrophage chemotaxis (GO:0048246)2.52916979
78mannosylation (GO:0097502)2.52221794
79base-excision repair, AP site formation (GO:0006285)2.51654387
80GTP biosynthetic process (GO:0006183)2.45380684
81deoxyribose phosphate catabolic process (GO:0046386)2.45216428
82negative regulation of appetite (GO:0032099)2.45152433
83negative regulation of response to food (GO:0032096)2.45152433
84inner mitochondrial membrane organization (GO:0007007)2.43484787
85protein targeting to membrane (GO:0006612)2.43431962
86anterograde synaptic vesicle transport (GO:0048490)2.43201579
87viral protein processing (GO:0019082)2.43156921
88intracellular protein transmembrane import (GO:0044743)2.40270550
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.38396352
90negative regulation of cation channel activity (GO:2001258)2.38037682
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37378431
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.35992267
93regulation of mononuclear cell migration (GO:0071675)2.34413497
94positive regulation of monocyte chemotaxis (GO:0090026)2.33897562
95protein-cofactor linkage (GO:0018065)2.30706919
96pyrimidine-containing compound catabolic process (GO:0072529)2.28775615
97translation (GO:0006412)2.28725107
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.27830962
99glycerophospholipid catabolic process (GO:0046475)2.25962989
100epithelial cilium movement (GO:0003351)2.25645884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70750122
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.47847286
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13490661
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94227763
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73711908
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70743158
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.70325631
8CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.65144098
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50822172
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39893709
11EZH2_22144423_ChIP-Seq_EOC_Human2.38042095
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29947763
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.11156106
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.08195929
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07659589
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.02402120
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.02060850
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.96321582
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88989274
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.75898372
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66967927
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.66702155
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62269383
24VDR_23849224_ChIP-Seq_CD4+_Human1.59918765
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58796975
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57484988
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55289575
28CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40290577
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.39069419
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38772284
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37024008
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.36655928
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36066860
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35042115
35BCL6_27268052_Chip-Seq_Bcells_Human1.34011402
36PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33648720
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33616518
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32270076
39* TAF2_19829295_ChIP-Seq_ESCs_Human1.29212631
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28514824
41TP53_22573176_ChIP-Seq_HFKS_Human1.27561983
42VDR_22108803_ChIP-Seq_LS180_Human1.27524166
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26613185
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26086359
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25874785
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.25853145
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23927573
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22675768
49HTT_18923047_ChIP-ChIP_STHdh_Human1.22486734
50CTCF_20526341_ChIP-Seq_ESCs_Human1.21382435
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.20503329
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19632363
53ERG_20517297_ChIP-Seq_VCAP_Human1.19188566
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18638469
55NANOG_20526341_ChIP-Seq_ESCs_Human1.18567849
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.18455327
57ZNF274_21170338_ChIP-Seq_K562_Hela1.14605858
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.14542007
59MYC_19829295_ChIP-Seq_ESCs_Human1.14330105
60STAT1_20625510_ChIP-Seq_HELA_Human1.11615427
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11106260
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10625277
63REST_21632747_ChIP-Seq_MESCs_Mouse1.09243250
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08699193
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07845937
66RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06833689
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.06588763
68ELK1_19687146_ChIP-ChIP_HELA_Human1.05297667
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05251898
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05163047
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.04446186
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04321479
73* GATA3_21878914_ChIP-Seq_MCF-7_Human1.03878622
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03259393
75AR_20517297_ChIP-Seq_VCAP_Human1.01979917
76* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99467619
77* FOXA1_25329375_ChIP-Seq_VCAP_Human0.99467619
78REST_18959480_ChIP-ChIP_MESCs_Mouse0.99072537
79JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97671289
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97560053
81NCOR_22424771_ChIP-Seq_293T_Human0.96928407
82ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96755987
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96550095
84MYC_18940864_ChIP-ChIP_HL60_Human0.96490894
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95894652
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95203485
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94918743
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94672888
89FOXP3_21729870_ChIP-Seq_TREG_Human0.93981801
90P300_27268052_Chip-Seq_Bcells_Human0.93089566
91NANOG_19829295_ChIP-Seq_ESCs_Human0.93014001
92SOX2_19829295_ChIP-Seq_ESCs_Human0.93014001
93GBX2_23144817_ChIP-Seq_PC3_Human0.92971529
94JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92192730
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90950356
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90821562
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90179387
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89854215
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.88965010
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88715455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.57050108
2MP0009379_abnormal_foot_pigmentation3.46286094
3MP0003011_delayed_dark_adaptation2.44528589
4MP0001905_abnormal_dopamine_level2.38340900
5MP0003880_abnormal_central_pattern2.14176512
6MP0005671_abnormal_response_to2.12394357
7MP0003136_yellow_coat_color2.00805037
8MP0006082_CNS_inflammation1.98198527
9MP0000343_altered_response_to1.94187361
10MP0003186_abnormal_redox_activity1.89400627
11MP0005084_abnormal_gallbladder_morpholo1.86466061
12MP0010386_abnormal_urinary_bladder1.85811765
13MP0006072_abnormal_retinal_apoptosis1.80376742
14MP0002148_abnormal_hypersensitivity_rea1.80149772
15MP0005058_abnormal_lysosome_morphology1.73695333
16MP0003806_abnormal_nucleotide_metabolis1.73279420
17MP0003122_maternal_imprinting1.71544633
18MP0001970_abnormal_pain_threshold1.69230006
19MP0001984_abnormal_olfaction1.68989573
20MP0002163_abnormal_gland_morphology1.68720648
21MP0003123_paternal_imprinting1.68679327
22MP0000372_irregular_coat_pigmentation1.67553528
23MP0003787_abnormal_imprinting1.66923177
24MP0009046_muscle_twitch1.63138289
25MP0009785_altered_susceptibility_to1.56486401
26MP0004142_abnormal_muscle_tone1.56414298
27MP0001542_abnormal_bone_strength1.56278975
28MP0002736_abnormal_nociception_after1.48983087
29MP0001968_abnormal_touch/_nociception1.46882272
30MP0002638_abnormal_pupillary_reflex1.45621984
31MP0005646_abnormal_pituitary_gland1.44866674
32MP0009745_abnormal_behavioral_response1.42467315
33MP0006292_abnormal_olfactory_placode1.41442321
34MP0003075_altered_response_to1.39844978
35MP0002733_abnormal_thermal_nociception1.39541626
36MP0005551_abnormal_eye_electrophysiolog1.39347194
37MP0002653_abnormal_ependyma_morphology1.35734132
38MP0009764_decreased_sensitivity_to1.35218710
39MP0005379_endocrine/exocrine_gland_phen1.32261303
40MP0002095_abnormal_skin_pigmentation1.30743963
41MP0006276_abnormal_autonomic_nervous1.30658960
42MP0004742_abnormal_vestibular_system1.29550736
43MP0001485_abnormal_pinna_reflex1.27538752
44MP0002272_abnormal_nervous_system1.23493972
45MP0005464_abnormal_platelet_physiology1.23051960
46MP0002277_abnormal_respiratory_mucosa1.21982994
47MP0001529_abnormal_vocalization1.21706960
48MP0008789_abnormal_olfactory_epithelium1.20374345
49MP0002064_seizures1.19591446
50MP0002295_abnormal_pulmonary_circulatio1.18102967
51MP0005174_abnormal_tail_pigmentation1.17581925
52MP0003121_genomic_imprinting1.16820858
53MP0004510_myositis1.15105273
54MP0001835_abnormal_antigen_presentation1.12380333
55MP0005000_abnormal_immune_tolerance1.10634603
56MP0006036_abnormal_mitochondrial_physio1.10482639
57MP0005253_abnormal_eye_physiology1.09915795
58MP0002938_white_spotting1.07954148
59MP0005645_abnormal_hypothalamus_physiol1.07632400
60MP0002572_abnormal_emotion/affect_behav1.07405109
61MP0002876_abnormal_thyroid_physiology1.04775001
62MP0001756_abnormal_urination1.04369655
63MP0002735_abnormal_chemical_nociception1.02053247
64MP0002557_abnormal_social/conspecific_i1.00716793
65MP0005025_abnormal_response_to0.99654564
66MP0000230_abnormal_systemic_arterial0.99439215
67MP0000026_abnormal_inner_ear0.97251535
68MP0001790_abnormal_immune_system0.96481222
69MP0005387_immune_system_phenotype0.96481222
70MP0002822_catalepsy0.95757729
71MP0002090_abnormal_vision0.95634278
72MP0005171_absent_coat_pigmentation0.95446261
73MP0003172_abnormal_lysosome_physiology0.95405019
74MP0002693_abnormal_pancreas_physiology0.92731708
75MP0001486_abnormal_startle_reflex0.91655813
76MP0001963_abnormal_hearing_physiology0.88902738
77MP0003646_muscle_fatigue0.88612689
78MP0001853_heart_inflammation0.86524419
79MP0006054_spinal_hemorrhage0.85260728
80MP0003633_abnormal_nervous_system0.84611099
81MP0005423_abnormal_somatic_nervous0.84263650
82MP0002102_abnormal_ear_morphology0.84071325
83MP0005503_abnormal_tendon_morphology0.83353992
84MP0001986_abnormal_taste_sensitivity0.82412656
85MP0001845_abnormal_inflammatory_respons0.82048902
86MP0000639_abnormal_adrenal_gland0.81327301
87MP0002909_abnormal_adrenal_gland0.81203447
88MP0010030_abnormal_orbit_morphology0.79896713
89MP0002234_abnormal_pharynx_morphology0.79302837
90MP0002723_abnormal_immune_serum0.78183212
91MP0002282_abnormal_trachea_morphology0.77954651
92MP0005075_abnormal_melanosome_morpholog0.74465567
93MP0002734_abnormal_mechanical_nocicepti0.74119284
94MP0002067_abnormal_sensory_capabilities0.71978805
95MP0005332_abnormal_amino_acid0.70585634
96MP0001501_abnormal_sleep_pattern0.70377294
97MP0003195_calcinosis0.69774201
98MP0002063_abnormal_learning/memory/cond0.69742049
99MP0008872_abnormal_physiological_respon0.69340170
100MP0004145_abnormal_muscle_electrophysio0.69248106

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.63869549
2Mitochondrial inheritance (HP:0001427)5.41609278
3Abnormal mitochondria in muscle tissue (HP:0008316)5.28346072
4Progressive macrocephaly (HP:0004481)4.91384629
5Hepatocellular necrosis (HP:0001404)4.65288560
6Renal Fanconi syndrome (HP:0001994)4.53941470
7Acute encephalopathy (HP:0006846)4.51786750
8Increased CSF lactate (HP:0002490)4.39512182
9Hepatic necrosis (HP:0002605)4.32208693
10Increased hepatocellular lipid droplets (HP:0006565)4.15426529
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.97973161
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.97973161
133-Methylglutaconic aciduria (HP:0003535)3.90949807
14Increased intramyocellular lipid droplets (HP:0012240)3.79603898
15Lipid accumulation in hepatocytes (HP:0006561)3.69551336
16Exertional dyspnea (HP:0002875)3.33701153
17Cerebral edema (HP:0002181)3.24639344
18Increased muscle lipid content (HP:0009058)3.16779773
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06107985
20Respiratory failure (HP:0002878)2.93121146
21Abnormality of liposaccharide metabolism (HP:0010968)2.90034191
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.90034191
23Abnormality of glycolipid metabolism (HP:0010969)2.90034191
24Myokymia (HP:0002411)2.86974137
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.85564401
26Abnormality of renal resorption (HP:0011038)2.83934825
27Abnormal number of erythroid precursors (HP:0012131)2.80465261
28Abnormality of cells of the erythroid lineage (HP:0012130)2.79809981
29True hermaphroditism (HP:0010459)2.76840677
30Molar tooth sign on MRI (HP:0002419)2.76704368
31Abnormality of midbrain morphology (HP:0002418)2.76704368
32Optic disc pallor (HP:0000543)2.73961987
33Congenital, generalized hypertrichosis (HP:0004540)2.68125663
34Generalized aminoaciduria (HP:0002909)2.66761954
35Polyphagia (HP:0002591)2.66566159
36Lactic acidosis (HP:0003128)2.59681956
37Pancreatic fibrosis (HP:0100732)2.59468123
38Vacuolated lymphocytes (HP:0001922)2.58486568
39Exercise intolerance (HP:0003546)2.53404597
40Medial flaring of the eyebrow (HP:0010747)2.49258004
41Prolonged neonatal jaundice (HP:0006579)2.47543354
42Petechiae (HP:0000967)2.46666681
43Pancreatic cysts (HP:0001737)2.39501848
44Methylmalonic aciduria (HP:0012120)2.38174444
45Reticulocytopenia (HP:0001896)2.34864232
46Glycosuria (HP:0003076)2.33885605
47Abnormality of urine glucose concentration (HP:0011016)2.33885605
48Agitation (HP:0000713)2.25981487
49Increased serum lactate (HP:0002151)2.22829708
50Leukodystrophy (HP:0002415)2.22681224
51Nephronophthisis (HP:0000090)2.22279533
52Sclerocornea (HP:0000647)2.19626796
53Dicarboxylic aciduria (HP:0003215)2.15220944
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15220944
55Cutaneous melanoma (HP:0012056)2.11103871
56Dysostosis multiplex (HP:0000943)2.08473395
57Aplastic anemia (HP:0001915)2.08031132
58Lethargy (HP:0001254)2.05830244
59Septo-optic dysplasia (HP:0100842)1.99667534
60Methylmalonic acidemia (HP:0002912)1.99046783
61Focal dystonia (HP:0004373)1.98631410
62Severe visual impairment (HP:0001141)1.98420354
63Emotional lability (HP:0000712)1.93957196
64Type I transferrin isoform profile (HP:0003642)1.92691758
65Respiratory difficulties (HP:0002880)1.91371056
66Progressive neurologic deterioration (HP:0002344)1.91081754
67Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90867346
68CNS demyelination (HP:0007305)1.90519202
69X-linked dominant inheritance (HP:0001423)1.89086953
70Macrocytic anemia (HP:0001972)1.88445743
71Hemiparesis (HP:0001269)1.86509629
72Purpura (HP:0000979)1.84190224
73Hyperphosphaturia (HP:0003109)1.82553220
74Abnormality of macrophages (HP:0004311)1.81389776
75Elevated erythrocyte sedimentation rate (HP:0003565)1.80910934
76Abnormal rod and cone electroretinograms (HP:0008323)1.79862532
77Craniofacial dystonia (HP:0012179)1.78944668
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78543029
79Albinism (HP:0001022)1.77843504
80Congenital stationary night blindness (HP:0007642)1.77265560
81Gait imbalance (HP:0002141)1.76087299
82Congenital primary aphakia (HP:0007707)1.75101861
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74693598
84Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74596516
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74295636
86Irregular vertebral endplates (HP:0003301)1.70013363
87Axonal loss (HP:0003447)1.69253423
88Nephrogenic diabetes insipidus (HP:0009806)1.66896267
89Hyperglycinemia (HP:0002154)1.65455936
90Increased IgM level (HP:0003496)1.65136330
91Hypoalbuminemia (HP:0003073)1.64554420
92Abnormal albumin level (HP:0012116)1.64554420
93Abnormal eating behavior (HP:0100738)1.63425615
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.62526533
95Decreased central vision (HP:0007663)1.59695187
96Blindness (HP:0000618)1.59618412
97Abnormal respiratory epithelium morphology (HP:0012253)1.59401662
98Abnormal respiratory motile cilium morphology (HP:0005938)1.59401662
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.58195006
100Progressive microcephaly (HP:0000253)1.55947915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.73124754
2BCKDK3.22589923
3LIMK12.88433313
4STK162.83707236
5TESK22.44966592
6TESK12.36818789
7EPHB22.31938425
8MAP3K122.22016912
9ADRBK22.20262783
10MAP4K22.16684537
11FRK2.00418612
12VRK11.99976610
13MYLK1.97831732
14NME21.92570249
15PIM21.89771339
16MAP3K111.87091862
17TXK1.74876465
18ZAK1.73095542
19GRK71.68801480
20KDR1.63099278
21TLK11.61708026
22GRK11.59131358
23CDK191.54478393
24DYRK21.54417082
25MAP2K71.54053636
26NUAK11.52689332
27ABL21.46024588
28PINK11.41939817
29CSNK1G31.37255619
30ARAF1.36837697
31DAPK31.35244605
32CAMKK21.32036804
33CSNK1G21.23358499
34PRKD31.17250042
35MST41.17176132
36MAPK151.16942072
37GRK51.16324284
38IKBKB1.12487425
39BMPR1B1.10163512
40ADRBK11.07540321
41CSNK1G11.03074925
42TAOK30.94871834
43CSNK1A1L0.93995560
44TBK10.89675061
45ILK0.88291998
46WNK30.87845817
47PRKCG0.87255385
48TAOK20.85535946
49PAK30.83794823
50EPHA40.82530312
51MAPKAPK30.80611450
52DAPK20.78909776
53LRRK20.76121392
54PRKCQ0.74808659
55IKBKE0.73249215
56INSRR0.72006099
57MUSK0.68116641
58DAPK10.67038333
59SYK0.66663853
60LMTK20.66087129
61PRKCE0.65845785
62KIT0.63335469
63PAK10.63258078
64PHKG10.62941081
65PHKG20.62941081
66TNK20.62870038
67PTK2B0.59423393
68ROCK10.58981362
69PLK20.58904935
70MAP3K40.58683922
71NTRK20.57711074
72MAP2K60.57676610
73PKN10.55974856
74MAPK130.55966013
75RPS6KA50.55832408
76CAMK2D0.54187503
77DDR20.53231896
78PNCK0.50717472
79ITK0.49878610
80CAMK2G0.49807161
81FES0.49153020
82FGFR20.48181119
83TAF10.47716738
84PRKCD0.46691499
85LYN0.46655359
86PRKACA0.44508673
87CSNK1A10.44308205
88PRKCA0.43775241
89MINK10.43684978
90AURKA0.43656912
91PIK3CG0.43248630
92CAMK10.42469973
93CAMK2A0.42188963
94MAPKAPK50.40620499
95MARK10.35213958
96TIE10.34569585
97TEC0.33758633
98WNK40.33061554
99CASK0.32362597
100TGFBR20.31291634

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.69261849
2Parkinsons disease_Homo sapiens_hsa050124.55827411
3Ribosome_Homo sapiens_hsa030103.72231248
4Proteasome_Homo sapiens_hsa030503.22520338
5Alzheimers disease_Homo sapiens_hsa050103.21340767
6Huntingtons disease_Homo sapiens_hsa050162.99642357
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.90630257
8Protein export_Homo sapiens_hsa030602.68527185
9Cardiac muscle contraction_Homo sapiens_hsa042602.60587263
10Collecting duct acid secretion_Homo sapiens_hsa049662.06904855
11Rheumatoid arthritis_Homo sapiens_hsa053231.91419804
12Sulfur metabolism_Homo sapiens_hsa009201.83516016
13RNA polymerase_Homo sapiens_hsa030201.75886892
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69422049
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60938203
16Type I diabetes mellitus_Homo sapiens_hsa049401.55496270
17Graft-versus-host disease_Homo sapiens_hsa053321.54652146
18Folate biosynthesis_Homo sapiens_hsa007901.50052256
19Asthma_Homo sapiens_hsa053101.49543974
20Allograft rejection_Homo sapiens_hsa053301.48246823
21Primary immunodeficiency_Homo sapiens_hsa053401.46318611
22Autoimmune thyroid disease_Homo sapiens_hsa053201.42404702
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41799149
24Glutathione metabolism_Homo sapiens_hsa004801.38544776
25Fatty acid elongation_Homo sapiens_hsa000621.33051513
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29656189
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.19981196
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.14606421
29Peroxisome_Homo sapiens_hsa041461.11781309
30Antigen processing and presentation_Homo sapiens_hsa046121.11669300
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.11261089
32Lysosome_Homo sapiens_hsa041421.08348622
33Synaptic vesicle cycle_Homo sapiens_hsa047211.08288758
34Phototransduction_Homo sapiens_hsa047441.04703177
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01552924
36Vibrio cholerae infection_Homo sapiens_hsa051101.00052843
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.99583210
38Sulfur relay system_Homo sapiens_hsa041220.98579278
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90108267
40Pyrimidine metabolism_Homo sapiens_hsa002400.89079032
41Butanoate metabolism_Homo sapiens_hsa006500.85904896
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84556500
43Hematopoietic cell lineage_Homo sapiens_hsa046400.82304654
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80194113
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79127686
46Arachidonic acid metabolism_Homo sapiens_hsa005900.78576175
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77300062
48Phagosome_Homo sapiens_hsa041450.75832571
49Salmonella infection_Homo sapiens_hsa051320.73704441
50Metabolic pathways_Homo sapiens_hsa011000.70473359
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67197036
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64979652
53Nicotine addiction_Homo sapiens_hsa050330.64101219
54Systemic lupus erythematosus_Homo sapiens_hsa053220.63680750
55Tryptophan metabolism_Homo sapiens_hsa003800.62663279
56Purine metabolism_Homo sapiens_hsa002300.62284204
57Mineral absorption_Homo sapiens_hsa049780.61304489
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61116143
59Chemical carcinogenesis_Homo sapiens_hsa052040.60528106
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60097425
61Linoleic acid metabolism_Homo sapiens_hsa005910.59623654
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59124733
63Other glycan degradation_Homo sapiens_hsa005110.58255560
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55799739
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55630501
66Staphylococcus aureus infection_Homo sapiens_hsa051500.53556803
67Regulation of autophagy_Homo sapiens_hsa041400.50963531
68GABAergic synapse_Homo sapiens_hsa047270.50454584
69Nitrogen metabolism_Homo sapiens_hsa009100.49351292
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46369809
71Homologous recombination_Homo sapiens_hsa034400.46121376
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45453115
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44766058
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44101838
75Ether lipid metabolism_Homo sapiens_hsa005650.42292305
76Morphine addiction_Homo sapiens_hsa050320.41799856
77Malaria_Homo sapiens_hsa051440.41721478
78Pertussis_Homo sapiens_hsa051330.40248176
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35556163
80Salivary secretion_Homo sapiens_hsa049700.34340991
81Steroid biosynthesis_Homo sapiens_hsa001000.33653851
82Insulin secretion_Homo sapiens_hsa049110.33153968
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32499077
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31618707
85Alcoholism_Homo sapiens_hsa050340.31417877
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30575959
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30110595
88Shigellosis_Homo sapiens_hsa051310.29605029
89Olfactory transduction_Homo sapiens_hsa047400.27918979
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27733875
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.27129507
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24778086
93N-Glycan biosynthesis_Homo sapiens_hsa005100.24774309
94Viral myocarditis_Homo sapiens_hsa054160.23201960
95Serotonergic synapse_Homo sapiens_hsa047260.22558781
96Circadian entrainment_Homo sapiens_hsa047130.21813501
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19818687
98Galactose metabolism_Homo sapiens_hsa000520.19729203
99Cocaine addiction_Homo sapiens_hsa050300.19082136
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18048961

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »