IFFO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)5.91587564
2axon ensheathment in central nervous system (GO:0032291)5.82430223
3central nervous system myelination (GO:0022010)5.82430223
4adenosine receptor signaling pathway (GO:0001973)5.45477519
5regulation of synapse structural plasticity (GO:0051823)5.16106376
6regulation of cytokine production involved in inflammatory response (GO:1900015)5.07972853
7mannose metabolic process (GO:0006013)4.96008629
8protein carboxylation (GO:0018214)4.86961928
9peptidyl-glutamic acid carboxylation (GO:0017187)4.86961928
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.75887620
11mitotic cell cycle arrest (GO:0071850)4.74466630
12cellular response to ATP (GO:0071318)4.69298948
13regulation of interferon-beta biosynthetic process (GO:0045357)4.51216737
14daunorubicin metabolic process (GO:0044597)4.39308846
15polyketide metabolic process (GO:0030638)4.39308846
16doxorubicin metabolic process (GO:0044598)4.39308846
17negative regulation of cell killing (GO:0031342)4.36908902
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36908902
19response to peptidoglycan (GO:0032494)4.18263905
20negative regulation of erythrocyte differentiation (GO:0045647)4.10018815
21negative regulation of interleukin-8 production (GO:0032717)4.06492606
22phosphatidylglycerol biosynthetic process (GO:0006655)4.05452817
23myelination (GO:0042552)4.04185709
24axon ensheathment (GO:0008366)4.03750607
25ensheathment of neurons (GO:0007272)4.03750607
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.03011150
27maintenance of protein location in nucleus (GO:0051457)4.02916949
28negative regulation of cell aging (GO:0090344)4.01788754
29positive regulation of gamma-delta T cell activation (GO:0046645)3.95200178
30regulation of response to osmotic stress (GO:0047484)3.82112503
31purinergic nucleotide receptor signaling pathway (GO:0035590)3.81588793
32detection of molecule of bacterial origin (GO:0032490)3.77155036
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76949062
34GDP-mannose metabolic process (GO:0019673)3.75862761
35macrophage activation involved in immune response (GO:0002281)3.74784316
36antigen processing and presentation of endogenous antigen (GO:0019883)3.71407377
37positive thymic T cell selection (GO:0045059)3.69350634
38modulation by symbiont of host immune response (GO:0052553)3.69024488
39positive regulation by symbiont of host defense response (GO:0052509)3.69024488
40modulation by symbiont of host defense response (GO:0052031)3.69024488
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69024488
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69024488
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.69024488
44regulation of mast cell degranulation (GO:0043304)3.68576139
45positive regulation of heat generation (GO:0031652)3.67177030
46regulation of T cell tolerance induction (GO:0002664)3.67068741
47lens fiber cell differentiation (GO:0070306)3.66058998
48transepithelial transport (GO:0070633)3.64133762
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58021266
50regulation of mast cell activation involved in immune response (GO:0033006)3.52332134
51long-chain fatty acid biosynthetic process (GO:0042759)3.51684131
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50285497
53purinergic receptor signaling pathway (GO:0035587)3.49633899
54G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.47045425
55positive regulation of mast cell activation involved in immune response (GO:0033008)3.43752839
56positive regulation of mast cell degranulation (GO:0043306)3.43752839
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42384916
58response to dietary excess (GO:0002021)3.42175111
59detection of light stimulus involved in sensory perception (GO:0050962)3.41548135
60detection of light stimulus involved in visual perception (GO:0050908)3.41548135
61positive regulation of mast cell activation (GO:0033005)3.38862777
62granulocyte differentiation (GO:0030851)3.37359490
63negative regulation of interleukin-12 production (GO:0032695)3.36614956
64oligodendrocyte differentiation (GO:0048709)3.36241612
65detection of external biotic stimulus (GO:0098581)3.32188843
66presynaptic membrane assembly (GO:0097105)3.30861132
67histone H3-K4 trimethylation (GO:0080182)3.26149387
68response to muramyl dipeptide (GO:0032495)3.26050660
69regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25957914
70presynaptic membrane organization (GO:0097090)3.22452302
71regulation of tolerance induction (GO:0002643)3.21791895
72regulation of leukocyte degranulation (GO:0043300)3.20544531
73protein polyglutamylation (GO:0018095)3.19046098
74negative regulation of toll-like receptor signaling pathway (GO:0034122)3.18529205
75synaptic vesicle maturation (GO:0016188)3.16416251
76L-amino acid import (GO:0043092)3.16252148
77regulation of MHC class I biosynthetic process (GO:0045343)3.14319883
78DNA strand renaturation (GO:0000733)3.13568219
79detection of other organism (GO:0098543)3.11022206
80semaphorin-plexin signaling pathway (GO:0071526)3.07920922
81regulation of phospholipid biosynthetic process (GO:0071071)3.07654992
82negative regulation of tumor necrosis factor production (GO:0032720)3.06905438
83regulation of mast cell activation (GO:0033003)3.06498476
84detection of bacterium (GO:0016045)3.03835615
85neuronal action potential propagation (GO:0019227)3.03579149
86neutrophil activation involved in immune response (GO:0002283)3.02322570
87negative regulation of innate immune response (GO:0045824)3.02124506
88protein palmitoylation (GO:0018345)3.01549210
89response to ATP (GO:0033198)3.01011732
90negative regulation of granulocyte differentiation (GO:0030853)2.99954167
91myeloid cell activation involved in immune response (GO:0002275)2.99519249
92transmission of nerve impulse (GO:0019226)2.99331793
93neuron cell-cell adhesion (GO:0007158)2.98179574
94negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.96713021
95regulation of ARF GTPase activity (GO:0032312)2.91839798
96regulation of cilium movement (GO:0003352)2.91700547
97regulation of gamma-delta T cell activation (GO:0046643)2.90678942
98negative regulation of neurotransmitter secretion (GO:0046929)2.86398453
99GPI anchor biosynthetic process (GO:0006506)2.86359845
100detection of biotic stimulus (GO:0009595)2.85405025
101cardiolipin metabolic process (GO:0032048)2.83319172
102adult walking behavior (GO:0007628)2.81072029
103regulation of B cell receptor signaling pathway (GO:0050855)2.78609671
104interferon-gamma production (GO:0032609)2.76226007
105positive T cell selection (GO:0043368)2.74621752
106detection of temperature stimulus (GO:0016048)2.72309318
107somite rostral/caudal axis specification (GO:0032525)2.71958505
108regulation of regulated secretory pathway (GO:1903305)2.69565149
109positive regulation of interferon-alpha production (GO:0032727)2.68607035
110regulation of interferon-beta production (GO:0032648)2.68416900
111positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.68295358
112histone H4-K12 acetylation (GO:0043983)2.67196164
113endocytic recycling (GO:0032456)2.66786711
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66540265
115regulation of heat generation (GO:0031650)2.66472342
116leukocyte aggregation (GO:0070486)2.65966055
117immunoglobulin mediated immune response (GO:0016064)2.65673597
118glycolipid biosynthetic process (GO:0009247)2.65186070
119macrophage activation (GO:0042116)2.63760340
120regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63402318
121positive regulation of action potential (GO:0045760)2.62974284
122myelin maintenance (GO:0043217)2.62704567
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62096272
124phenol-containing compound catabolic process (GO:0019336)2.61821415
125glycerophospholipid catabolic process (GO:0046475)2.61261588
126negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.60412869
127GPI anchor metabolic process (GO:0006505)2.58489005
128negative regulation of neurotransmitter transport (GO:0051589)2.58372354
129phosphatidylinositol 3-kinase signaling (GO:0014065)2.58350111
130tachykinin receptor signaling pathway (GO:0007217)2.58094181
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.57624691
132positive regulation of leukocyte degranulation (GO:0043302)2.57017476
133neuronal ion channel clustering (GO:0045161)2.56338944
134positive regulation of antigen processing and presentation (GO:0002579)2.56327848
135preassembly of GPI anchor in ER membrane (GO:0016254)2.55991037
136modulation by virus of host process (GO:0019054)2.55595817
137regulation of interferon-alpha production (GO:0032647)2.55570804
138histone H4-K5 acetylation (GO:0043981)2.55452393
139histone H4-K8 acetylation (GO:0043982)2.55452393
140aminoglycoside antibiotic metabolic process (GO:0030647)2.54295845
141cellular extravasation (GO:0045123)2.52998077
142regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.52012316
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.50758197
144amino sugar catabolic process (GO:0046348)2.50617578
145cell fate commitment involved in formation of primary germ layer (GO:0060795)2.50015012
146adaptation of signaling pathway (GO:0023058)2.49841833
147peptidyl-tyrosine autophosphorylation (GO:0038083)2.49564033
148regulation of gamma-delta T cell differentiation (GO:0045586)2.49037083
149positive regulation of protein kinase C signaling (GO:0090037)2.48784950
150histone H3-K4 methylation (GO:0051568)2.48547745
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48220337
152negative regulation of execution phase of apoptosis (GO:1900118)2.47569791
153protein localization to cilium (GO:0061512)2.47199536
154response to host immune response (GO:0052572)2.46955979
155calcium-mediated signaling using intracellular calcium source (GO:0035584)2.45947154
156regulation of collateral sprouting (GO:0048670)2.44770292
157amino acid import (GO:0043090)2.43630440
158negative regulation of axonogenesis (GO:0050771)2.42220376
159ventricular system development (GO:0021591)2.39979424
160nucleoside transmembrane transport (GO:1901642)2.38489463
161positive regulation of interleukin-17 production (GO:0032740)2.37429882
162spinal cord motor neuron differentiation (GO:0021522)2.36276456
163negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.32266612
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.31164907
165Golgi to endosome transport (GO:0006895)2.30617225
166cerebellar granule cell differentiation (GO:0021707)2.29811787
167synaptic transmission, glutamatergic (GO:0035249)2.29742980
168cellular response to epinephrine stimulus (GO:0071872)2.28155459
169cyclic nucleotide catabolic process (GO:0009214)2.27700988
170neuromuscular synaptic transmission (GO:0007274)2.27099917
171negative regulation of protein localization to cell surface (GO:2000009)2.25207983
172photoreceptor cell differentiation (GO:0046530)2.25074411
173eye photoreceptor cell differentiation (GO:0001754)2.25074411
174forebrain neuron differentiation (GO:0021879)2.23526852
175microtubule severing (GO:0051013)2.22610563
176astrocyte development (GO:0014002)2.22262359
177positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21813223
178nerve growth factor signaling pathway (GO:0038180)2.21478909
179mitochondrion distribution (GO:0048311)2.20009629
180ionotropic glutamate receptor signaling pathway (GO:0035235)2.19575118
181cranial nerve development (GO:0021545)2.17992446
182negative regulation of epidermis development (GO:0045683)2.16446869
183postsynaptic membrane organization (GO:0001941)2.16324191
184nonmotile primary cilium assembly (GO:0035058)2.15271320
185establishment of mitochondrion localization (GO:0051654)2.14223117
186regulation of microtubule-based movement (GO:0060632)2.14149043
187regulation of short-term neuronal synaptic plasticity (GO:0048172)2.12401420
188regulation of pigment cell differentiation (GO:0050932)2.11821724
189neuronal action potential (GO:0019228)2.11803830
190cerebral cortex radially oriented cell migration (GO:0021799)2.11086778
191histone H4-K16 acetylation (GO:0043984)2.10125121
192activated T cell proliferation (GO:0050798)2.09732791
193neurotransmitter uptake (GO:0001504)2.09652137
194response to epinephrine (GO:0071871)2.08970356
195G-protein coupled receptor internalization (GO:0002031)2.08778541
196positive regulation of defense response to virus by host (GO:0002230)2.08396490
197myelination in peripheral nervous system (GO:0022011)2.07777883
198peripheral nervous system axon ensheathment (GO:0032292)2.07777883
199negative regulation of axon extension (GO:0030517)2.06423331
200startle response (GO:0001964)2.06198748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.36901657
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.27695422
3EZH2_22144423_ChIP-Seq_EOC_Human3.45718799
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.34640317
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.34640317
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.34640317
7GBX2_23144817_ChIP-Seq_PC3_Human3.08816388
8LXR_22292898_ChIP-Seq_THP-1_Human3.08223367
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.76389272
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73597132
11VDR_24763502_ChIP-Seq_THP-1_Human2.66219813
12MAF_26560356_Chip-Seq_TH2_Human2.56805630
13* P68_20966046_ChIP-Seq_HELA_Human2.51617964
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43360234
15MAF_26560356_Chip-Seq_TH1_Human2.34328976
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33166865
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.31455447
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.27153991
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26157707
20BCL6_27268052_Chip-Seq_Bcells_Human2.25483343
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22989692
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20426520
23KDM2B_26808549_Chip-Seq_DND41_Human2.16720868
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16085249
25* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12998049
26UTX_26944678_Chip-Seq_JUKART_Human2.09705329
27* BCOR_27268052_Chip-Seq_Bcells_Human2.08028589
28* CTCF_27219007_Chip-Seq_ERYTHROID_Human2.05836714
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03471516
30MYC_22102868_ChIP-Seq_BL_Human1.99614758
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.97969528
32* E2F1_20622854_ChIP-Seq_HELA_Human1.97815667
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97424327
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97424327
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96760888
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96532167
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93849624
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88028785
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.87418556
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.86110778
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.83630532
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.82102918
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81976606
44* TCF7_22412390_ChIP-Seq_EML_Mouse1.79007419
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.76775120
46REST_21632747_ChIP-Seq_MESCs_Mouse1.75655456
47* TET1_21451524_ChIP-Seq_MESCs_Mouse1.74478701
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74060255
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73683939
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73615532
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73404706
52* SA1_27219007_Chip-Seq_ERYTHROID_Human1.73242788
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73104617
54DROSHA_22980978_ChIP-Seq_HELA_Human1.72867596
55RACK7_27058665_Chip-Seq_MCF-7_Human1.72461027
56* PHF8_20622854_ChIP-Seq_HELA_Human1.72170079
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71503963
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71382797
59CTCF_27219007_Chip-Seq_Bcells_Human1.71167302
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70702359
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70633331
62RNF2_27304074_Chip-Seq_NSC_Mouse1.70142763
63* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.68668556
64SMC4_20622854_ChIP-Seq_HELA_Human1.67241452
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65527608
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.59255165
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59160404
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58900005
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57157225
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56638653
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54506895
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.53126648
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52860000
74* RUNX1_22412390_ChIP-Seq_EML_Mouse1.52269243
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51987559
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51866645
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51431311
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.50739948
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49813571
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.49463087
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48722102
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48683596
83* CTCF_20526341_ChIP-Seq_ESCs_Human1.48131176
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.48044790
85* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47994695
86RARB_24833708_ChIP-Seq_LIVER_Mouse1.47586940
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46868163
88TP53_22127205_ChIP-Seq_IMR90_Human1.46617975
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44206702
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44117039
91* CTCF_21964334_Chip-Seq_Bcells_Human1.43856312
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43731417
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43677830
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42288240
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.41617280
96* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40221486
97* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.39881939
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39802843
99IRF1_19129219_ChIP-ChIP_H3396_Human1.38318020
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.37636900
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36740799
102* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.36605358
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35855473
104* SA1_27219007_Chip-Seq_Bcells_Human1.35198969
105* RARA_24833708_ChIP-Seq_LIVER_Mouse1.32592544
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.32091850
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30779008
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30725561
109KDM2B_26808549_Chip-Seq_K562_Human1.30555191
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29931988
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29662783
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29198382
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29002637
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.28534012
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28433190
116VDR_22108803_ChIP-Seq_LS180_Human1.27776189
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27034704
118REST_18959480_ChIP-ChIP_MESCs_Mouse1.25878924
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25447356
120CREB1_26743006_Chip-Seq_LNCaP_Human1.23804278
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.23504569
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22820719
123* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22557192
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22506871
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21384132
126IGF1R_20145208_ChIP-Seq_DFB_Human1.20775841
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19074482
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18447795
129* FOXP1_21924763_ChIP-Seq_HESCs_Human1.17890381
130GATA1_19941827_ChIP-Seq_MEL_Mouse1.17599580
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17588447
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17422801
133SPI1_23547873_ChIP-Seq_NB4_Human1.16920733
134RING1B_27294783_Chip-Seq_NPCs_Mouse1.15892600
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14410946
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14133847
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13928632
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13202320
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13083232
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12951837
141SPI1_20517297_ChIP-Seq_HL60_Human1.12576653
142CIITA_25753668_ChIP-Seq_RAJI_Human1.12226986
143* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11785651
144* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11637591
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10990191
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10783877
147OCT4_19829295_ChIP-Seq_ESCs_Human1.10111011
148P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10057013
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09698729
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08854469
151TP63_19390658_ChIP-ChIP_HaCaT_Human1.08551118
152JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08034369
153SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07543252
154* ETS1_21867929_ChIP-Seq_TH2_Mouse1.07437234
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06433198
156STAT3_23295773_ChIP-Seq_U87_Human1.06411484
157P300_18555785_Chip-Seq_ESCs_Mouse1.04371493
158KLF4_18555785_Chip-Seq_ESCs_Mouse1.04235853
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03615950
160SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03465733
161SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03064925
162SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02605668
163CMYC_18555785_Chip-Seq_ESCs_Mouse1.02347639
164E2F1_18555785_Chip-Seq_ESCs_Mouse1.02110036
165CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01819400
166NANOG_18555785_Chip-Seq_ESCs_Mouse1.01487813
167NMYC_18555785_Chip-Seq_ESCs_Mouse1.01037571
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.99918467
169SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99277854
170TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99188231
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99028252
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.98425542
173ZFX_18555785_Chip-Seq_ESCs_Mouse0.98207894
174EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95986774
175TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94882912
176POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94882912
177AHR_22903824_ChIP-Seq_MCF-7_Human0.93915772
178RING1B_27294783_Chip-Seq_ESCs_Mouse0.93194315
179WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93071648
180CTCF_18555785_Chip-Seq_ESCs_Mouse0.92903849
181SMAD4_21799915_ChIP-Seq_A2780_Human0.92702818
182SOX2_18555785_Chip-Seq_ESCs_Mouse0.90713242
183ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90669646
184PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89033075
185SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88699692
186SCL_19346495_ChIP-Seq_HPC-7_Human0.88625742
187TCF4_23295773_ChIP-Seq_U87_Human0.88529243
188LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88452732
189OCT4_18555785_Chip-Seq_ESCs_Mouse0.88119296
190NFE2_27457419_Chip-Seq_LIVER_Mouse0.87748445
191STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85223450
192SMAD3_21741376_ChIP-Seq_EPCs_Human0.83275312
193P53_22387025_ChIP-Seq_ESCs_Mouse0.82920290
194CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82897765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.36590637
2MP0005174_abnormal_tail_pigmentation3.31279603
3MP0006292_abnormal_olfactory_placode3.24746079
4MP0003303_peritoneal_inflammation3.09558134
5MP0005058_abnormal_lysosome_morphology3.07812889
6MP0003436_decreased_susceptibility_to2.98264831
7MP0003880_abnormal_central_pattern2.83888244
8MP0000920_abnormal_myelination2.71301422
9MP0001486_abnormal_startle_reflex2.50575259
10MP0009046_muscle_twitch2.34012492
11MP0004859_abnormal_synaptic_plasticity2.25499947
12MP0003724_increased_susceptibility_to2.17973629
13MP0001835_abnormal_antigen_presentation2.09000533
14MP0002734_abnormal_mechanical_nocicepti2.08431508
15MP0004142_abnormal_muscle_tone2.07871464
16MP0005075_abnormal_melanosome_morpholog2.07762958
17MP0000751_myopathy2.07133025
18MP0002419_abnormal_innate_immunity2.05009291
19MP0002272_abnormal_nervous_system2.02819952
20MP0005423_abnormal_somatic_nervous2.00970477
21MP0009278_abnormal_bone_marrow2.00837095
22MP0002064_seizures1.99798910
23MP0009840_abnormal_foam_cell1.99762860
24MP0003787_abnormal_imprinting1.98834080
25MP0003183_abnormal_peptide_metabolism1.96813623
26MP0001986_abnormal_taste_sensitivity1.95845097
27MP0003136_yellow_coat_color1.95825640
28MP0008875_abnormal_xenobiotic_pharmacok1.95680438
29MP0000685_abnormal_immune_system1.93352190
30MP0004130_abnormal_muscle_cell1.87847943
31MP0003635_abnormal_synaptic_transmissio1.86378707
32MP0005025_abnormal_response_to1.86034324
33MP0005409_darkened_coat_color1.82798996
34MP0001790_abnormal_immune_system1.82390407
35MP0005387_immune_system_phenotype1.82390407
36MP0004381_abnormal_hair_follicle1.80424476
37MP0002148_abnormal_hypersensitivity_rea1.79186764
38MP0005410_abnormal_fertilization1.79050331
39MP0002723_abnormal_immune_serum1.77048757
40MP0005000_abnormal_immune_tolerance1.75405399
41MP0001800_abnormal_humoral_immune1.75133875
42MP0004145_abnormal_muscle_electrophysio1.72941638
43MP0009745_abnormal_behavioral_response1.72615058
44MP0002572_abnormal_emotion/affect_behav1.72266760
45MP0005671_abnormal_response_to1.70860865
46MP0002452_abnormal_antigen_presenting1.69417907
47MP0001958_emphysema1.68255934
48MP0005394_taste/olfaction_phenotype1.68237616
49MP0005499_abnormal_olfactory_system1.68237616
50MP0005171_absent_coat_pigmentation1.64833357
51MP0003011_delayed_dark_adaptation1.62562629
52MP0001905_abnormal_dopamine_level1.62555116
53MP0003122_maternal_imprinting1.62537037
54MP0000955_abnormal_spinal_cord1.62167824
55MP0003279_aneurysm1.61416719
56MP0002420_abnormal_adaptive_immunity1.59886125
57MP0001819_abnormal_immune_cell1.58303634
58MP0000750_abnormal_muscle_regeneration1.58202439
59MP0004742_abnormal_vestibular_system1.56658227
60MP0002638_abnormal_pupillary_reflex1.54193593
61MP0000778_abnormal_nervous_system1.53812385
62MP0006082_CNS_inflammation1.50317410
63MP0002933_joint_inflammation1.50044299
64MP0002277_abnormal_respiratory_mucosa1.48915945
65MP0003938_abnormal_ear_development1.48612684
66MP0005330_cardiomyopathy1.47260918
67MP0002254_reproductive_system_inflammat1.46983704
68MP0005551_abnormal_eye_electrophysiolog1.46018484
69MP0001970_abnormal_pain_threshold1.44438356
70MP0003634_abnormal_glial_cell1.43846628
71MP0002229_neurodegeneration1.43741034
72MP0005083_abnormal_biliary_tract1.40534519
73MP0003950_abnormal_plasma_membrane1.40408283
74MP0004858_abnormal_nervous_system1.39458339
75MP0002752_abnormal_somatic_nervous1.38358225
76MP0002063_abnormal_learning/memory/cond1.37666008
77MP0004885_abnormal_endolymph1.36246118
78MP0003690_abnormal_glial_cell1.35814096
79MP0001661_extended_life_span1.34355370
80MP0009785_altered_susceptibility_to1.34072595
81MP0002067_abnormal_sensory_capabilities1.33956423
82MP0000749_muscle_degeneration1.33052533
83MP0001533_abnormal_skeleton_physiology1.32436348
84MP0002882_abnormal_neuron_morphology1.32185909
85MP0002733_abnormal_thermal_nociception1.32010600
86MP0001756_abnormal_urination1.31923094
87MP0002184_abnormal_innervation1.31493567
88MP0002735_abnormal_chemical_nociception1.29237987
89MP0002653_abnormal_ependyma_morphology1.28172302
90MP0003453_abnormal_keratinocyte_physiol1.27923487
91MP0002332_abnormal_exercise_endurance1.27182009
92MP0002405_respiratory_system_inflammati1.25927105
93MP0000716_abnormal_immune_system1.24584199
94MP0001968_abnormal_touch/_nociception1.23903190
95MP0001188_hyperpigmentation1.22762549
96MP0003448_altered_tumor_morphology1.20301328
97MP0008569_lethality_at_weaning1.19409886
98MP0001873_stomach_inflammation1.17616205
99MP0002398_abnormal_bone_marrow1.17338244
100MP0001963_abnormal_hearing_physiology1.17231758
101MP0005379_endocrine/exocrine_gland_phen1.16017868
102MP0003172_abnormal_lysosome_physiology1.15615362
103MP0008469_abnormal_protein_level1.14443331
104MP0000858_altered_metastatic_potential1.14295278
105MP0001984_abnormal_olfaction1.14221571
106MP0000604_amyloidosis1.12990409
107MP0003705_abnormal_hypodermis_morpholog1.12641030
108MP0002557_abnormal_social/conspecific_i1.12587319
109MP0002998_abnormal_bone_remodeling1.11856472
110MP0001348_abnormal_lacrimal_gland1.11770158
111MP0002736_abnormal_nociception_after1.11694024
112MP0005623_abnormal_meninges_morphology1.11149399
113MP0005253_abnormal_eye_physiology1.10953422
114MP0005257_abnormal_intraocular_pressure1.10172145
115MP0001845_abnormal_inflammatory_respons1.08440514
116MP0010155_abnormal_intestine_physiology1.05816563
117MP0003763_abnormal_thymus_physiology1.05592425
118MP0003300_gastrointestinal_ulcer1.05451063
119MP0000566_synostosis1.04305430
120MP0001501_abnormal_sleep_pattern1.03404154
121MP0006072_abnormal_retinal_apoptosis1.01160194
122MP0002429_abnormal_blood_cell1.00627789
123MP0003191_abnormal_cellular_cholesterol1.00345783
124MP0001440_abnormal_grooming_behavior1.00344388
125MP0003121_genomic_imprinting0.99524679
126MP0003045_fibrosis0.98861224
127MP0003632_abnormal_nervous_system0.98349274
128MP0000383_abnormal_hair_follicle0.98247833
129MP0000631_abnormal_neuroendocrine_gland0.97238175
130MP0003890_abnormal_embryonic-extraembry0.97156446
131MP0000747_muscle_weakness0.96776451
132MP0009333_abnormal_splenocyte_physiolog0.96682605
133MP0004510_myositis0.96590785
134MP0001485_abnormal_pinna_reflex0.95464992
135MP0002066_abnormal_motor_capabilities/c0.95329999
136MP0003329_amyloid_beta_deposits0.93575794
137MP0000026_abnormal_inner_ear0.91525934
138MP0000689_abnormal_spleen_morphology0.91513190
139MP0000343_altered_response_to0.91296792
140MP0004133_heterotaxia0.90367672
141MP0003091_abnormal_cell_migration0.90251487
142MP0005645_abnormal_hypothalamus_physiol0.89641301
143MP0000013_abnormal_adipose_tissue0.89090000
144MP0002722_abnormal_immune_system0.88486387
145MP0004264_abnormal_extraembryonic_tissu0.88438873
146MP0005464_abnormal_platelet_physiology0.88343736
147MP0008057_abnormal_DNA_replication0.87198443
148MP0009764_decreased_sensitivity_to0.86816984
149MP0001529_abnormal_vocalization0.86539475
150MP0002751_abnormal_autonomic_nervous0.85596795
151MP0001919_abnormal_reproductive_system0.85574921
152MP0004947_skin_inflammation0.82862614
153MP0008874_decreased_physiological_sensi0.82604248
154MP0003806_abnormal_nucleotide_metabolis0.81736581
155MP0000767_abnormal_smooth_muscle0.79632093
156MP0005195_abnormal_posterior_eye0.79627480
157MP0005365_abnormal_bile_salt0.79541633
158MP0001542_abnormal_bone_strength0.79497489
159MP0005310_abnormal_salivary_gland0.78898977
160MP0003828_pulmonary_edema0.78495056
161MP0008260_abnormal_autophagy0.78493449
162MP0005166_decreased_susceptibility_to0.78243002
163MP0005584_abnormal_enzyme/coenzyme_acti0.78105786
164MP0002160_abnormal_reproductive_system0.77677439
165MP0000703_abnormal_thymus_morphology0.77569458
166MP0000470_abnormal_stomach_morphology0.77477407
167MP0009384_cardiac_valve_regurgitation0.77239930
168MP0005646_abnormal_pituitary_gland0.77071819
169MP0001502_abnormal_circadian_rhythm0.76639158
170MP0000003_abnormal_adipose_tissue0.75831780
171MP0008961_abnormal_basal_metabolism0.75698755
172MP0001545_abnormal_hematopoietic_system0.74359115
173MP0005397_hematopoietic_system_phenotyp0.74359115
174MP0000762_abnormal_tongue_morphology0.74122383
175MP0004811_abnormal_neuron_physiology0.72100934
176MP0004043_abnormal_pH_regulation0.71996836
177MP0002152_abnormal_brain_morphology0.71211168
178MP0003137_abnormal_impulse_conducting0.71069501
179MP0002114_abnormal_axial_skeleton0.70380597
180MP0005391_vision/eye_phenotype0.69532072
181MP0003698_abnormal_male_reproductive0.68733931
182MP0006276_abnormal_autonomic_nervous0.68028597
183MP0000015_abnormal_ear_pigmentation0.67810655

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)5.67214583
2Hemorrhage of the eye (HP:0011885)4.69639066
3Joint hemorrhage (HP:0005261)4.51389382
4Sensory axonal neuropathy (HP:0003390)4.36807162
5Attenuation of retinal blood vessels (HP:0007843)4.13886321
6Annular pancreas (HP:0001734)4.10957740
7Thin bony cortex (HP:0002753)4.04305510
8Facial diplegia (HP:0001349)3.90597348
9Choroideremia (HP:0001139)3.64200048
10Fetal akinesia sequence (HP:0001989)3.61277104
11Akinesia (HP:0002304)3.58483933
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.53140361
13Absent/shortened dynein arms (HP:0200106)3.53140361
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45871105
15Prolonged partial thromboplastin time (HP:0003645)3.44055368
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.43926234
17Renal Fanconi syndrome (HP:0001994)3.40973988
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.37280263
19Bilateral microphthalmos (HP:0007633)3.36874919
20Ulnar bowing (HP:0003031)3.33350284
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.26357905
22Abnormality of polysaccharide metabolism (HP:0011012)3.26357905
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.26357905
24Febrile seizures (HP:0002373)3.24288392
25Turricephaly (HP:0000262)3.14421501
26Decreased central vision (HP:0007663)3.13622777
27Increased hepatocellular lipid droplets (HP:0006565)3.08569662
28Joint stiffness (HP:0001387)3.05356093
29Vaginal fistula (HP:0004320)3.03193502
30Urinary glycosaminoglycan excretion (HP:0003541)3.01870729
31Mucopolysacchariduria (HP:0008155)3.01870729
32Chronic mucocutaneous candidiasis (HP:0002728)2.98420755
33Recurrent cutaneous fungal infections (HP:0011370)2.98420755
34Abnormality of the intrinsic pathway (HP:0010989)2.93862649
35Eczematoid dermatitis (HP:0000976)2.92277750
36Abnormality of glycolipid metabolism (HP:0010969)2.92069829
37Abnormality of liposaccharide metabolism (HP:0010968)2.92069829
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.92069829
39Atrioventricular block (HP:0001678)2.91831914
40Lipid accumulation in hepatocytes (HP:0006561)2.89717101
41Rib fusion (HP:0000902)2.88574879
42Upper limb muscle weakness (HP:0003484)2.86635929
43Gastrointestinal infarctions (HP:0005244)2.86566560
44Dysostosis multiplex (HP:0000943)2.85046428
45Abnormality of the corticospinal tract (HP:0002492)2.82574159
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.81385847
47Duplicated collecting system (HP:0000081)2.80338998
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.79801819
49Hypoplasia of the fovea (HP:0007750)2.79801819
50Partial duplication of thumb phalanx (HP:0009944)2.79028575
51Poikiloderma (HP:0001029)2.73555424
52Zonular cataract (HP:0010920)2.73045351
53Abnormality of macrophages (HP:0004311)2.71191143
54Abnormal ciliary motility (HP:0012262)2.67949888
55Exertional dyspnea (HP:0002875)2.66876117
56Recurrent abscess formation (HP:0002722)2.66775338
57Anomalous pulmonary venous return (HP:0010772)2.66588293
58Chromsome breakage (HP:0040012)2.65168524
59Epileptic encephalopathy (HP:0200134)2.63850094
60Recurrent bacterial skin infections (HP:0005406)2.63352526
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61140660
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61078100
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.61078100
64Atonic seizures (HP:0010819)2.59965201
65Supranuclear gaze palsy (HP:0000605)2.57618164
66Abnormal albumin level (HP:0012116)2.54928135
67Hypoalbuminemia (HP:0003073)2.54928135
68Bony spicule pigmentary retinopathy (HP:0007737)2.52569098
69Recurrent skin infections (HP:0001581)2.52527694
70Aplasia of the musculature (HP:0100854)2.50335722
71Abnormality of the costochondral junction (HP:0000919)2.48450024
72Increased muscle lipid content (HP:0009058)2.46343976
73Popliteal pterygium (HP:0009756)2.45372240
74Abnormality of the renal collecting system (HP:0004742)2.44433493
75Abnormal auditory evoked potentials (HP:0006958)2.42866870
76Abnormality of the common coagulation pathway (HP:0010990)2.42200714
77Increased intramyocellular lipid droplets (HP:0012240)2.39762748
78Abnormality of the fovea (HP:0000493)2.39349289
79Onion bulb formation (HP:0003383)2.38293639
80Delayed epiphyseal ossification (HP:0002663)2.37119244
81Recurrent fungal infections (HP:0002841)2.36701782
82Duplication of thumb phalanx (HP:0009942)2.35326109
83Dyschromatopsia (HP:0007641)2.33564173
84Myotonia (HP:0002486)2.33441942
85Cheilitis (HP:0100825)2.32640541
86Myositis (HP:0100614)2.32496870
87Nephroblastoma (Wilms tumor) (HP:0002667)2.29964586
88Intestinal fistula (HP:0100819)2.27173534
89Abnormal respiratory motile cilium physiology (HP:0012261)2.24004352
90Respiratory difficulties (HP:0002880)2.23235633
91Pustule (HP:0200039)2.21840213
92Recurrent gram-negative bacterial infections (HP:0005420)2.21444415
93Asymmetric septal hypertrophy (HP:0001670)2.20903892
94Global brain atrophy (HP:0002283)2.20181918
95Systemic lupus erythematosus (HP:0002725)2.17774063
96Enlarged epiphyses (HP:0010580)2.17123074
97Diminished movement (HP:0002374)2.16572090
98Rectal fistula (HP:0100590)2.16125991
99Rectovaginal fistula (HP:0000143)2.16125991
100Partial duplication of the phalanx of hand (HP:0009999)2.15481309
101Peripheral hypomyelination (HP:0007182)2.14910055
102Elevated erythrocyte sedimentation rate (HP:0003565)2.13756319
103Coronal craniosynostosis (HP:0004440)2.13354761
104Osteomalacia (HP:0002749)2.12915503
105Neonatal onset (HP:0003623)2.12876914
106Atelectasis (HP:0100750)2.12556154
107Abnormal respiratory epithelium morphology (HP:0012253)2.11477302
108Abnormal respiratory motile cilium morphology (HP:0005938)2.11477302
109Rapidly progressive (HP:0003678)2.10519258
110Hypophosphatemic rickets (HP:0004912)2.10408071
111Abnormality of the pulmonary veins (HP:0011718)2.09851697
112Obstructive lung disease (HP:0006536)2.07842585
113Chronic obstructive pulmonary disease (HP:0006510)2.07842585
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07350349
115Embryonal renal neoplasm (HP:0011794)2.06245684
116Spastic gait (HP:0002064)2.06170646
117Facial hemangioma (HP:0000329)2.05479924
118Epistaxis (HP:0000421)2.05269705
119Macular degeneration (HP:0000608)2.04517125
120Focal motor seizures (HP:0011153)2.03533286
121Hemiparesis (HP:0001269)2.02790364
122Spontaneous hematomas (HP:0007420)2.02363721
123Slow saccadic eye movements (HP:0000514)2.01505566
124Squamous cell carcinoma (HP:0002860)2.00733006
125Thin ribs (HP:0000883)2.00279920
126Testicular atrophy (HP:0000029)1.99217133
127Focal seizures (HP:0007359)1.97700612
128Absent septum pellucidum (HP:0001331)1.97418259
129Difficulty running (HP:0009046)1.96873028
130Hypochromic microcytic anemia (HP:0004840)1.96676186
131Congenital stationary night blindness (HP:0007642)1.96602542
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95792033
133Cervical subluxation (HP:0003308)1.95728975
134Increased cerebral lipofuscin (HP:0011813)1.95640868
135Dysmetria (HP:0001310)1.95582729
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.95082356
137Septo-optic dysplasia (HP:0100842)1.95060761
138Parakeratosis (HP:0001036)1.93603272
139Neurofibrillary tangles (HP:0002185)1.92130944
140Abnormality of renal resorption (HP:0011038)1.91284864
141Orchitis (HP:0100796)1.90922713
142Abnormality of placental membranes (HP:0011409)1.90682425
143Amniotic constriction ring (HP:0009775)1.90682425
144Widely patent fontanelles and sutures (HP:0004492)1.90491840
145Hyperventilation (HP:0002883)1.90328298
146Steppage gait (HP:0003376)1.89727321
1473-Methylglutaconic aciduria (HP:0003535)1.88334569
148Anteriorly placed anus (HP:0001545)1.88059269
149Myokymia (HP:0002411)1.87420374
150Type 2 muscle fiber atrophy (HP:0003554)1.87364107
151Malignant hyperthermia (HP:0002047)1.86808774
152Progressive cerebellar ataxia (HP:0002073)1.86074501
153Heart block (HP:0012722)1.86007583
154Easy fatigability (HP:0003388)1.85325119
155Flat occiput (HP:0005469)1.83021622
156Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83007831
157Gowers sign (HP:0003391)1.81276116
158Abnormality of the salivary glands (HP:0010286)1.81273032
159Chin dimple (HP:0010751)1.80664860
160Absent speech (HP:0001344)1.80367278
161Nasolacrimal duct obstruction (HP:0000579)1.78961175
162Progressive external ophthalmoplegia (HP:0000590)1.73372922
163Microvesicular hepatic steatosis (HP:0001414)1.72826679
164Abnormality of the septum pellucidum (HP:0007375)1.71709306
165Cystic hygroma (HP:0000476)1.71478306
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71341729
167Dialeptic seizures (HP:0011146)1.70786246
168Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70278379
169Preauricular pit (HP:0004467)1.65453269
170Periauricular skin pits (HP:0100277)1.65453269
171Ocular albinism (HP:0001107)1.64366654
172Gaze-evoked nystagmus (HP:0000640)1.63367258
173Weak cry (HP:0001612)1.63049819
174Horizontal nystagmus (HP:0000666)1.62678476
175Decreased motor nerve conduction velocity (HP:0003431)1.62539353
176Ankle clonus (HP:0011448)1.62049625
177Round ear (HP:0100830)1.61428914
178Medial flaring of the eyebrow (HP:0010747)1.61190538
179Aplasia/Hypoplasia of the macula (HP:0008059)1.61088244
180Nonprogressive disorder (HP:0003680)1.59055596
181Molar tooth sign on MRI (HP:0002419)1.58586602
182Abnormality of midbrain morphology (HP:0002418)1.58586602
183Abnormality of calcium-phosphate metabolism (HP:0100530)1.58379293
184Ectopic anus (HP:0004397)1.57445357
185Iris hypopigmentation (HP:0007730)1.56050767
186Tented upper lip vermilion (HP:0010804)1.55615840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.72807967
2GRK53.20359574
3TNIK2.76853537
4WNK12.73376803
5ADRBK22.68492660
6MAP4K12.61648201
7GRK12.48102174
8GRK72.44618080
9MAP2K32.43000878
10STK392.41352554
11PRPF4B2.12080480
12ZAP701.99120716
13CSF1R1.94108305
14MOS1.91991084
15OXSR11.88825451
16MARK21.80593266
17TYK21.80104677
18MAPK71.79152922
19MUSK1.77541599
20TRIB31.74525236
21TYRO31.72433054
22PKN11.72254031
23TBK11.70889311
24CASK1.67944778
25NEK61.67433689
26IRAK21.65310015
27TGFBR21.58739031
28MAP3K111.55405214
29TESK21.55271479
30IRAK31.50538374
31SIK31.48463120
32NTRK11.48462012
33MAPK151.47566614
34EPHB11.47090211
35ICK1.46193885
36IRAK41.41007308
37DYRK1B1.39886824
38SIK11.33790928
39PDPK11.32627325
40CLK11.32412897
41NTRK31.32400264
42IKBKE1.29859285
43MAP2K71.27809307
44SYK1.27330381
45TLK11.26891046
46GRK61.26423608
47JAK31.25370634
48HIPK21.24016419
49BRD41.20784155
50TNK21.17380721
51CDK191.14931105
52FES1.12940047
53EPHA41.10782151
54DAPK21.09221726
55BTK1.08290863
56IRAK11.05163375
57BLK1.03048336
58LYN1.02030843
59PRKD21.00333954
60KIT0.99789674
61PNCK0.99056253
62MARK10.98443656
63UHMK10.97900931
64CDC42BPA0.97821309
65NTRK20.97201181
66MAP3K140.96510056
67TXK0.95716608
68SIK20.95417286
69BMX0.92837531
70MATK0.92642911
71MAP3K30.91818622
72PAK60.90802812
73CAMKK10.89835398
74CAMK40.89768620
75RIPK40.86837471
76TAOK10.85517990
77MAP2K60.85216291
78RPS6KA20.84527022
79MARK30.83487160
80DDR20.82855470
81WNK40.82560503
82CAMK1G0.81256149
83RPS6KC10.79875697
84RPS6KL10.79875697
85INSRR0.78983914
86CDK40.78942153
87PDK10.78879536
88CDK60.78146421
89FGR0.76857592
90STK160.76635718
91RPS6KA60.76446717
92LCK0.76445974
93CDK50.75266227
94MAPK130.73999384
95TTK0.71736723
96MAPKAPK50.70916095
97CAMKK20.69182351
98MAP3K130.68603649
99MAP2K40.68190248
100CDK30.68159613
101CSNK1A1L0.68012652
102JAK10.66791085
103CAMK2B0.66686364
104BMPR20.66306118
105SGK2230.66248707
106SGK4940.66248707
107TAOK20.65705309
108CSK0.64525117
109JAK20.62781557
110PRKD10.62212402
111MAPK120.59688480
112ADRBK10.59619494
113ERN10.59409085
114CDK150.59311680
115CAMK10.58022635
116MAPK100.57203014
117ARAF0.56934168
118DYRK1A0.56742658
119MAPK110.56560489
120EIF2AK20.55795501
121CDK180.55057852
122CAMK2D0.54414874
123ROCK20.54378901
124CDK11A0.53958450
125PAK10.52352198
126MAP3K10.51541129
127HCK0.50447804
128PRKCQ0.49945422
129STK380.49686633
130MAP3K90.48423746
131CDK140.47766883
132PRKCH0.47453193
133ITK0.46721949
134YES10.46091898
135CAMK2A0.45703053
136TRIM280.43409496
137ZAK0.43346916
138CCNB10.42818074
139BCR0.42134899
140CSNK1G30.41847585
141CHEK20.41277699
142MAP3K40.41037131
143IKBKB0.40889547
144STK110.40874546
145PRKCE0.40871700
146KSR20.40227865
147PRKG10.38633121
148KDR0.38621047
149CAMK2G0.37841716
150MAP3K70.37141414
151TTN0.36430091
152PRKD30.36341859
153FYN0.36301932
154PRKCD0.35630262
155RIPK10.30743410

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.22264270
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.04275943
3Staphylococcus aureus infection_Homo sapiens_hsa051502.17414553
4Osteoclast differentiation_Homo sapiens_hsa043802.12711819
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05498916
6Sulfur relay system_Homo sapiens_hsa041221.99254649
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95669393
8Ether lipid metabolism_Homo sapiens_hsa005651.93485170
9Glutamatergic synapse_Homo sapiens_hsa047241.93267779
10Leishmaniasis_Homo sapiens_hsa051401.86591209
11Serotonergic synapse_Homo sapiens_hsa047261.85341609
12Taste transduction_Homo sapiens_hsa047421.74513479
13Vitamin B6 metabolism_Homo sapiens_hsa007501.67129670
14Morphine addiction_Homo sapiens_hsa050321.66229129
15Phototransduction_Homo sapiens_hsa047441.63487262
16Nicotine addiction_Homo sapiens_hsa050331.62921672
17Tuberculosis_Homo sapiens_hsa051521.56983811
18GABAergic synapse_Homo sapiens_hsa047271.56869230
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51603137
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.50657899
21Other glycan degradation_Homo sapiens_hsa005111.46795759
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46153186
23Axon guidance_Homo sapiens_hsa043601.45632810
24Arachidonic acid metabolism_Homo sapiens_hsa005901.40631781
25Asthma_Homo sapiens_hsa053101.40113917
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39557086
27Circadian entrainment_Homo sapiens_hsa047131.39146394
28Sphingolipid metabolism_Homo sapiens_hsa006001.38572783
29Olfactory transduction_Homo sapiens_hsa047401.36649848
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34387325
31Synaptic vesicle cycle_Homo sapiens_hsa047211.31478766
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.30741800
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30624754
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27935798
35Long-term depression_Homo sapiens_hsa047301.27002196
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20335648
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20132110
38Linoleic acid metabolism_Homo sapiens_hsa005911.18979565
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17511300
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16689932
41Malaria_Homo sapiens_hsa051441.16622368
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16594530
43Calcium signaling pathway_Homo sapiens_hsa040201.15887181
44Salivary secretion_Homo sapiens_hsa049701.12871121
45Ovarian steroidogenesis_Homo sapiens_hsa049131.10416895
46Cholinergic synapse_Homo sapiens_hsa047251.09340851
47Insulin secretion_Homo sapiens_hsa049111.06178238
48Pertussis_Homo sapiens_hsa051331.05617471
49Inositol phosphate metabolism_Homo sapiens_hsa005621.04940323
50Dopaminergic synapse_Homo sapiens_hsa047281.03065203
51Fanconi anemia pathway_Homo sapiens_hsa034601.02156097
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01297115
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00937214
54VEGF signaling pathway_Homo sapiens_hsa043700.99833602
55Toxoplasmosis_Homo sapiens_hsa051450.99651989
56cAMP signaling pathway_Homo sapiens_hsa040240.97870802
57Long-term potentiation_Homo sapiens_hsa047200.97842244
58Dorso-ventral axis formation_Homo sapiens_hsa043200.97500226
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.96475978
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.96388187
61Collecting duct acid secretion_Homo sapiens_hsa049660.96279513
62Choline metabolism in cancer_Homo sapiens_hsa052310.95880360
63Ras signaling pathway_Homo sapiens_hsa040140.95855444
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.94721419
65Oxytocin signaling pathway_Homo sapiens_hsa049210.94393505
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94265746
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.94216398
68GnRH signaling pathway_Homo sapiens_hsa049120.93459542
69Amphetamine addiction_Homo sapiens_hsa050310.92394933
70Cocaine addiction_Homo sapiens_hsa050300.92025668
71Fructose and mannose metabolism_Homo sapiens_hsa000510.90480078
72TNF signaling pathway_Homo sapiens_hsa046680.90436662
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.90316382
74Type I diabetes mellitus_Homo sapiens_hsa049400.89671367
75Acute myeloid leukemia_Homo sapiens_hsa052210.88908668
76ErbB signaling pathway_Homo sapiens_hsa040120.88620632
77Phagosome_Homo sapiens_hsa041450.86492625
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86139476
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84589076
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83632781
81Renin secretion_Homo sapiens_hsa049240.83267480
82MAPK signaling pathway_Homo sapiens_hsa040100.83233800
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80285892
84Rheumatoid arthritis_Homo sapiens_hsa053230.79320880
85Antigen processing and presentation_Homo sapiens_hsa046120.78311158
86Autoimmune thyroid disease_Homo sapiens_hsa053200.77575182
87Viral myocarditis_Homo sapiens_hsa054160.76558302
88Chemokine signaling pathway_Homo sapiens_hsa040620.75613579
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75066420
90B cell receptor signaling pathway_Homo sapiens_hsa046620.74655645
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74606733
92Influenza A_Homo sapiens_hsa051640.73915857
93Measles_Homo sapiens_hsa051620.72720947
94mTOR signaling pathway_Homo sapiens_hsa041500.72102849
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70595164
96Dilated cardiomyopathy_Homo sapiens_hsa054140.70503478
97T cell receptor signaling pathway_Homo sapiens_hsa046600.69429230
98Gastric acid secretion_Homo sapiens_hsa049710.68652518
99Lysosome_Homo sapiens_hsa041420.68631034
100Notch signaling pathway_Homo sapiens_hsa043300.68087577
101Herpes simplex infection_Homo sapiens_hsa051680.67563205
102Rap1 signaling pathway_Homo sapiens_hsa040150.67458816
103Regulation of autophagy_Homo sapiens_hsa041400.66692419
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65927900
105Wnt signaling pathway_Homo sapiens_hsa043100.65618335
106Endocytosis_Homo sapiens_hsa041440.65374498
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64582541
108Hepatitis C_Homo sapiens_hsa051600.62808833
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.62097059
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59864000
111Cardiac muscle contraction_Homo sapiens_hsa042600.59471645
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.59155942
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.58776996
114Platelet activation_Homo sapiens_hsa046110.58279684
115Circadian rhythm_Homo sapiens_hsa047100.58081479
116Hedgehog signaling pathway_Homo sapiens_hsa043400.58067415
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57692126
118African trypanosomiasis_Homo sapiens_hsa051430.56854059
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56701435
120Apoptosis_Homo sapiens_hsa042100.56470670
121Hematopoietic cell lineage_Homo sapiens_hsa046400.56360593
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55649941
123Graft-versus-host disease_Homo sapiens_hsa053320.54618114
124Primary immunodeficiency_Homo sapiens_hsa053400.54500213
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54218070
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54131532
127Salmonella infection_Homo sapiens_hsa051320.53643772
128Hepatitis B_Homo sapiens_hsa051610.52687889
129Allograft rejection_Homo sapiens_hsa053300.50326953
130Non-small cell lung cancer_Homo sapiens_hsa052230.50250300
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49696479
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49199004
133Melanogenesis_Homo sapiens_hsa049160.48784035
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48747027
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.48275741
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48098253
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48030928
138Vibrio cholerae infection_Homo sapiens_hsa051100.47745045
139Renal cell carcinoma_Homo sapiens_hsa052110.46513141
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45902632
141Bladder cancer_Homo sapiens_hsa052190.45376570
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44827924
143Insulin resistance_Homo sapiens_hsa049310.44586803
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42187830
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37819875
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34734396
147Chronic myeloid leukemia_Homo sapiens_hsa052200.33955090
148Complement and coagulation cascades_Homo sapiens_hsa046100.33211572
149HTLV-I infection_Homo sapiens_hsa051660.31462469
150FoxO signaling pathway_Homo sapiens_hsa040680.28052988

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