IER5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)7.16141552
2heparin metabolic process (GO:0030202)5.23204133
3heparin biosynthetic process (GO:0030210)5.23204133
4regulation of apoptotic process involved in morphogenesis (GO:1902337)5.00349019
5dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.24255840
6cell-cell junction maintenance (GO:0045217)4.21866654
7barbed-end actin filament capping (GO:0051016)4.18937712
8outer ear morphogenesis (GO:0042473)4.08011819
9tooth mineralization (GO:0034505)4.02622012
10heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.95567210
11protein heterotrimerization (GO:0070208)3.86292354
12semaphorin-plexin signaling pathway (GO:0071526)3.84226120
13post-anal tail morphogenesis (GO:0036342)3.77187717
14viral transcription (GO:0019083)3.76517017
15translational termination (GO:0006415)3.63726578
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60787087
17regulation of hippo signaling (GO:0035330)3.55597070
18establishment of apical/basal cell polarity (GO:0035089)3.54147676
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53435147
20polarized epithelial cell differentiation (GO:0030859)3.49618854
21regulation of posttranscriptional gene silencing (GO:0060147)3.38143933
22regulation of gene silencing by miRNA (GO:0060964)3.38143933
23regulation of gene silencing by RNA (GO:0060966)3.38143933
24paraxial mesoderm development (GO:0048339)3.33223725
25maternal placenta development (GO:0001893)3.31531324
26chondrocyte proliferation (GO:0035988)3.31471482
27metanephric mesenchyme development (GO:0072075)3.27986581
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26654764
29mannose metabolic process (GO:0006013)3.21758378
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.21075809
31regulation of SMAD protein import into nucleus (GO:0060390)3.20477446
32embryonic process involved in female pregnancy (GO:0060136)3.20020234
33heparan sulfate proteoglycan metabolic process (GO:0030201)3.19509783
34glomerular visceral epithelial cell development (GO:0072015)3.19187163
35apoptotic process involved in morphogenesis (GO:0060561)3.19117018
36hippo signaling (GO:0035329)3.17968957
37kidney mesenchyme development (GO:0072074)3.17827532
38diaphragm development (GO:0060539)3.17754836
39negative regulation of catenin import into nucleus (GO:0035414)3.17514000
40positive regulation of odontogenesis (GO:0042482)3.16842327
41regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.16770500
42cell migration involved in heart development (GO:0060973)3.14718768
43nodal signaling pathway (GO:0038092)3.14145335
44branching involved in salivary gland morphogenesis (GO:0060445)3.13653508
45ribosomal small subunit biogenesis (GO:0042274)3.11192833
46positive regulation of SMAD protein import into nucleus (GO:0060391)3.10534662
47oligosaccharide catabolic process (GO:0009313)3.08652997
48pattern specification involved in kidney development (GO:0061004)3.08532984
49middle ear morphogenesis (GO:0042474)3.06114260
50glomerular basement membrane development (GO:0032836)3.05836447
51embryonic skeletal joint morphogenesis (GO:0060272)3.05693145
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05632231
53glial cell migration (GO:0008347)3.04447946
54mesonephros development (GO:0001823)3.04202289
55cell junction maintenance (GO:0034331)3.00215704
56cell migration in hindbrain (GO:0021535)2.99624799
57mesoderm development (GO:0007498)2.99385202
58negative regulation of cell size (GO:0045792)2.97595574
59protein localization to endosome (GO:0036010)2.97370316
60translational elongation (GO:0006414)2.96737858
61cochlea morphogenesis (GO:0090103)2.95922177
62protein retention in ER lumen (GO:0006621)2.95323613
63establishment or maintenance of monopolar cell polarity (GO:0061339)2.94745482
64establishment of monopolar cell polarity (GO:0061162)2.94745482
65skeletal muscle organ development (GO:0060538)2.93420717
66atrioventricular valve morphogenesis (GO:0003181)2.93297611
67cartilage morphogenesis (GO:0060536)2.93139181
68adherens junction assembly (GO:0034333)2.93031577
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.92934468
70bone trabecula formation (GO:0060346)2.92852367
71trophectodermal cell differentiation (GO:0001829)2.92428648
72regulation of integrin activation (GO:0033623)2.91032406
73UV protection (GO:0009650)2.89955285
74skin morphogenesis (GO:0043589)2.88567263
75positive regulation of epithelial to mesenchymal transition (GO:0010718)2.87539075
76neuron remodeling (GO:0016322)2.86611131
77notochord development (GO:0030903)2.86311757
78peptidyl-arginine omega-N-methylation (GO:0035247)2.85624317
79negative regulation of chondrocyte differentiation (GO:0032331)2.84319111
80positive regulation of protein homooligomerization (GO:0032464)2.83561125
81negative regulation of fatty acid transport (GO:2000192)2.82823244
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.82741952
83cellular protein complex disassembly (GO:0043624)2.82325933
84endothelial cell chemotaxis (GO:0035767)2.81941304
85glomerular epithelial cell development (GO:0072310)2.81575787
86negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.81172353
87regulation of heart morphogenesis (GO:2000826)2.80904269
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80520850
89embryonic camera-type eye development (GO:0031076)2.80011936
90adenosine receptor signaling pathway (GO:0001973)2.78799987
91regulation of cell proliferation involved in kidney development (GO:1901722)2.78770337
92basement membrane organization (GO:0071711)2.78704175
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.78054502
94collagen fibril organization (GO:0030199)2.76194900
95amino sugar catabolic process (GO:0046348)2.75901967
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75390372
97desmosome organization (GO:0002934)2.74859421
98urogenital system development (GO:0001655)2.73744926
99regulation of early endosome to late endosome transport (GO:2000641)2.72185637
100endothelial cell morphogenesis (GO:0001886)2.71835280
101virion attachment to host cell (GO:0019062)2.71180784
102adhesion of symbiont to host cell (GO:0044650)2.71180784
103epithelial cell-cell adhesion (GO:0090136)2.71064036
104plasma membrane repair (GO:0001778)2.70203163
105positive regulation of extracellular matrix organization (GO:1903055)2.69689071
106apoptotic process involved in development (GO:1902742)2.69558022
107translational initiation (GO:0006413)2.68101084
108positive regulation of endothelial cell apoptotic process (GO:2000353)2.67093074
109lung morphogenesis (GO:0060425)2.66991477
110hemidesmosome assembly (GO:0031581)2.66976498
111G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.65508011
112epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.65193737
113regulation of tight junction assembly (GO:2000810)2.64556719
114viral life cycle (GO:0019058)2.64464509
115face development (GO:0060324)2.64396061
116regulation of p38MAPK cascade (GO:1900744)2.64377997
117regulation of fatty acid beta-oxidation (GO:0031998)2.63270681
118negative regulation of Ras GTPase activity (GO:0034261)2.63060508
119embryo implantation (GO:0007566)2.60372646
120cell-substrate adherens junction assembly (GO:0007045)2.60293857
121focal adhesion assembly (GO:0048041)2.60293857
122negative regulation of embryonic development (GO:0045992)2.60292357
123adhesion of symbiont to host (GO:0044406)2.59967644
124segment specification (GO:0007379)2.59334218
125ncRNA 3-end processing (GO:0043628)2.59058291
126mammary gland epithelial cell differentiation (GO:0060644)2.58066384
127endodermal cell differentiation (GO:0035987)2.57914637
128positive regulation of gastrulation (GO:2000543)2.57706711
129vascular endothelial growth factor signaling pathway (GO:0038084)2.56825497
130blood vessel endothelial cell migration (GO:0043534)2.56480050
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56340812
132protein complex disassembly (GO:0043241)2.56020452
133cell migration involved in sprouting angiogenesis (GO:0002042)2.55703342
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.55124276
135axon extension involved in axon guidance (GO:0048846)2.55124276
136embryonic cranial skeleton morphogenesis (GO:0048701)2.54834357
137negative regulation of mRNA processing (GO:0050686)2.54703098
138cell-substrate junction assembly (GO:0007044)2.51849108
139negative regulation of cartilage development (GO:0061037)2.51740941
140ear development (GO:0043583)2.50477444
141labyrinthine layer blood vessel development (GO:0060716)2.50287745
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.49923123
143actin filament bundle assembly (GO:0051017)2.49786054
144actin filament bundle organization (GO:0061572)2.49786054
145regulation of establishment of planar polarity (GO:0090175)2.49558149
146heterochromatin organization (GO:0070828)2.49452588
147regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.49391975
148establishment of tissue polarity (GO:0007164)2.49291342
149establishment of planar polarity (GO:0001736)2.49291342
150cell proliferation involved in metanephros development (GO:0072203)2.49167916
151lymph vessel development (GO:0001945)2.48988882
152neural crest cell development (GO:0014032)2.48848684
153branching involved in mammary gland duct morphogenesis (GO:0060444)2.48725616
154response to laminar fluid shear stress (GO:0034616)2.47844153
155embryonic body morphogenesis (GO:0010172)2.47009987
156anatomical structure regression (GO:0060033)2.46933525
157eyelid development in camera-type eye (GO:0061029)2.46247521
158GDP-mannose metabolic process (GO:0019673)2.45906258
159positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45605344
160body morphogenesis (GO:0010171)2.45508976
161ventricular cardiac muscle cell development (GO:0055015)2.45252742
162craniofacial suture morphogenesis (GO:0097094)2.45143295
163trophoblast giant cell differentiation (GO:0060707)2.45037945
164cellular response to nutrient (GO:0031670)2.43866710
165SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.43661558
166endocardial cushion development (GO:0003197)2.42669950
167wound healing, spreading of epidermal cells (GO:0035313)2.42588645
168apoptotic cell clearance (GO:0043277)2.40770281
169cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40550280
170response to acidic pH (GO:0010447)2.39936938
171modulation by virus of host process (GO:0019054)2.39804631
172decidualization (GO:0046697)2.39355542
173regulation of mesenchymal cell apoptotic process (GO:2001053)2.39303141
174activation of Rac GTPase activity (GO:0032863)2.39136531
175modulation by symbiont of host cellular process (GO:0044068)2.37762593
176cell differentiation involved in embryonic placenta development (GO:0060706)2.36172055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.37369812
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.90467868
3* FOXM1_23109430_ChIP-Seq_U2OS_Human3.28711333
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.11864726
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.71646548
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.58510610
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54245514
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54245514
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54245514
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48556600
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41030188
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38472079
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25788014
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13293241
15* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11496340
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.10993875
17ZNF263_19887448_ChIP-Seq_K562_Human2.05394837
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04268996
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00800092
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91572808
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.88374380
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87884476
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.87346993
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86643436
25* TP53_20018659_ChIP-ChIP_R1E_Mouse1.85971464
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.85461005
27VDR_21846776_ChIP-Seq_THP-1_Human1.84812214
28* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81875338
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80543201
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79407756
31* KDM2B_26808549_Chip-Seq_DND41_Human1.79331851
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77447867
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.75886565
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75468972
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73783145
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69874962
37P68_20966046_ChIP-Seq_HELA_Human1.69484533
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68894179
39* KDM2B_26808549_Chip-Seq_JURKAT_Human1.68051044
40* KDM2B_26808549_Chip-Seq_K562_Human1.67824527
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67339551
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65202331
43XRN2_22483619_ChIP-Seq_HELA_Human1.65158671
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65083631
45* LXR_22292898_ChIP-Seq_THP-1_Human1.65070236
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64951644
47CLOCK_20551151_ChIP-Seq_293T_Human1.62924576
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61248438
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61187658
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.60771366
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56576627
52RACK7_27058665_Chip-Seq_MCF-7_Human1.53534849
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50668757
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47143884
55TCF7_22412390_ChIP-Seq_EML_Mouse1.46263981
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45367428
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45300183
58* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.44956289
59TTF2_22483619_ChIP-Seq_HELA_Human1.43394393
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43130260
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43014761
62TP53_22127205_ChIP-Seq_IMR90_Human1.41682985
63* SMC4_20622854_ChIP-Seq_HELA_Human1.39663370
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39536964
65* RING1B_27294783_Chip-Seq_NPCs_Mouse1.39485460
66* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39097774
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37863165
68MYC_22102868_ChIP-Seq_BL_Human1.36393162
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.36226037
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35053644
71VDR_24763502_ChIP-Seq_THP-1_Human1.34112073
72CTCF_27219007_Chip-Seq_Bcells_Human1.33457608
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32699452
74ATF3_27146783_Chip-Seq_COLON_Human1.31741009
75SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30033384
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26234456
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23447990
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23433670
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23012734
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22773001
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22433756
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21971344
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21925280
84* CREB1_26743006_Chip-Seq_LNCaP_Human1.21727196
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21276617
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.20645656
87* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19571908
88* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19054506
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17712573
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16714574
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.13987951
92* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13825857
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.11688820
94SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10806574
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09925317
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09603904
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.09472976
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08657550
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07270046
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07254578
101POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06891394
102BCOR_27268052_Chip-Seq_Bcells_Human1.06676791
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05150407
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05150407
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04876794
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04071714
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.03352027
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03159649
109CTCF_26484167_Chip-Seq_Bcells_Mouse1.01817025
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01099064
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00959813
112BCL6_27268052_Chip-Seq_Bcells_Human1.00801398
113CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00731990
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00233790
115* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99774370
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.99140043
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98842029
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98458932
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.98264802
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97909932
121* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95363831
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.94801480
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.92932581
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92881388
125EZH2_27294783_Chip-Seq_ESCs_Mouse0.92754785
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92530645
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92322026
128CTCF_21964334_Chip-Seq_Bcells_Human0.91936478
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91791281
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91315178
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.91281386
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91160414
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.90542610
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90182898
135AR_21572438_ChIP-Seq_LNCaP_Human0.90145575
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89926669
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.89755000
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89029263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.25035599
2MP0008438_abnormal_cutaneous_collagen3.77198589
3MP0003705_abnormal_hypodermis_morpholog3.71240862
4MP0005623_abnormal_meninges_morphology3.50966196
5MP0010030_abnormal_orbit_morphology3.47092639
6MP0003279_aneurysm2.86103508
7MP0004858_abnormal_nervous_system2.69612043
8MP0009840_abnormal_foam_cell2.69072500
9MP0002877_abnormal_melanocyte_morpholog2.63188095
10MP0005257_abnormal_intraocular_pressure2.51522616
11MP0005076_abnormal_cell_differentiation2.49609931
12MP0003091_abnormal_cell_migration2.37439785
13MP0005508_abnormal_skeleton_morphology2.17994972
14MP0002932_abnormal_joint_morphology2.16621448
15MP0003385_abnormal_body_wall2.16189951
16MP0004272_abnormal_basement_membrane2.16130556
17MP0003941_abnormal_skin_development2.02834583
18MP0002249_abnormal_larynx_morphology2.02674567
19MP0003755_abnormal_palate_morphology2.01149634
20MP0005503_abnormal_tendon_morphology1.99864871
21MP0005275_abnormal_skin_tensile1.98310744
22MP0010352_gastrointestinal_tract_polyps1.96407248
23MP0009384_cardiac_valve_regurgitation1.91324727
24MP0000049_abnormal_middle_ear1.90119373
25MP0005409_darkened_coat_color1.84232092
26MP0009053_abnormal_anal_canal1.83288591
27MP0002282_abnormal_trachea_morphology1.80026734
28MP0000733_abnormal_muscle_development1.75493687
29MP0009250_abnormal_appendicular_skeleto1.75414432
30MP0002111_abnormal_tail_morphology1.73894829
31MP0004185_abnormal_adipocyte_glucose1.73003338
32MP0003942_abnormal_urinary_system1.67543047
33MP0000767_abnormal_smooth_muscle1.63023789
34MP0004510_myositis1.62086953
35MP0000013_abnormal_adipose_tissue1.56673034
36MP0002089_abnormal_postnatal_growth/wei1.56580447
37MP0000428_abnormal_craniofacial_morphol1.55933925
38MP0003566_abnormal_cell_adhesion1.52790377
39MP0000762_abnormal_tongue_morphology1.50290519
40MP0009379_abnormal_foot_pigmentation1.50282532
41MP0005501_abnormal_skin_physiology1.48258197
42MP0000003_abnormal_adipose_tissue1.47503774
43MP0002796_impaired_skin_barrier1.46961448
44MP0009278_abnormal_bone_marrow1.42956050
45MP0002098_abnormal_vibrissa_morphology1.42753084
46MP0002114_abnormal_axial_skeleton1.40948495
47MP0002116_abnormal_craniofacial_bone1.40763206
48MP0002896_abnormal_bone_mineralization1.39047853
49MP0001958_emphysema1.35938369
50MP0000432_abnormal_head_morphology1.33681252
51MP0003191_abnormal_cellular_cholesterol1.32818265
52MP0008961_abnormal_basal_metabolism1.31052825
53MP0003119_abnormal_digestive_system1.30552093
54MP0003172_abnormal_lysosome_physiology1.29683736
55MP0002085_abnormal_embryonic_tissue1.29227903
56MP0000534_abnormal_ureter_morphology1.28347151
57MP0005023_abnormal_wound_healing1.27767894
58MP0003329_amyloid_beta_deposits1.27707056
59MP0000750_abnormal_muscle_regeneration1.26888989
60MP0005197_abnormal_uvea_morphology1.25749718
61MP0002653_abnormal_ependyma_morphology1.25551957
62MP0002998_abnormal_bone_remodeling1.24874108
63MP0003283_abnormal_digestive_organ1.24766147
64MP0002084_abnormal_developmental_patter1.23115735
65MP0003935_abnormal_craniofacial_develop1.21054849
66MP0003115_abnormal_respiratory_system1.19006049
67MP0003938_abnormal_ear_development1.18675725
68MP0002295_abnormal_pulmonary_circulatio1.18527443
69MP0004133_heterotaxia1.18071979
70MP0000343_altered_response_to1.18048129
71MP0000163_abnormal_cartilage_morphology1.18043135
72MP0003123_paternal_imprinting1.18007278
73MP0008932_abnormal_embryonic_tissue1.16108663
74MP0004197_abnormal_fetal_growth/weight/1.15255754
75MP0003937_abnormal_limbs/digits/tail_de1.15209363
76MP0001849_ear_inflammation1.14838406
77MP0002060_abnormal_skin_morphology1.14780730
78MP0000350_abnormal_cell_proliferation1.13421790
79MP0000751_myopathy1.13203264
80MP0003879_abnormal_hair_cell1.12695210
81MP0003828_pulmonary_edema1.12197817
82MP0001348_abnormal_lacrimal_gland1.11410915
83MP0001286_abnormal_eye_development1.08473462
84MP0000681_abnormal_thyroid_gland1.07986758
85MP0000604_amyloidosis1.06490291
86MP0004233_abnormal_muscle_weight1.06326331
87MP0003453_abnormal_keratinocyte_physiol1.06176679
88MP0000579_abnormal_nail_morphology1.05334777
89MP0008260_abnormal_autophagy1.04998877
90MP0002113_abnormal_skeleton_development1.04363106
91MP0002177_abnormal_outer_ear1.04006200
92MP0000538_abnormal_urinary_bladder1.02749904
93MP0008770_decreased_survivor_rate1.01876547
94MP0005083_abnormal_biliary_tract1.01212432
95MP0004019_abnormal_vitamin_homeostasis1.00810356
96MP0005595_abnormal_vascular_smooth1.00332907
97MP0010368_abnormal_lymphatic_system1.00195680
98MP0002925_abnormal_cardiovascular_devel0.98620923
99MP0000678_abnormal_parathyroid_gland0.98081846
100MP0001502_abnormal_circadian_rhythm0.97656415
101MP0003634_abnormal_glial_cell0.97435788
102MP0005367_renal/urinary_system_phenotyp0.96404310
103MP0000516_abnormal_urinary_system0.96404310
104MP0000858_altered_metastatic_potential0.95299532
105MP0003111_abnormal_nucleus_morphology0.94769031
106MP0002081_perinatal_lethality0.93211244
107MP0001614_abnormal_blood_vessel0.92493699
108MP0001697_abnormal_embryo_size0.92435368
109MP0001340_abnormal_eyelid_morphology0.92074054
110MP0002697_abnormal_eye_size0.91172581
111MP0001216_abnormal_epidermal_layer0.89466748
112MP0002109_abnormal_limb_morphology0.87911408
113MP0003861_abnormal_nervous_system0.86095372
114MP0002115_abnormal_skeleton_extremities0.85634568
115MP0005193_abnormal_anterior_eye0.85629544
116MP0000537_abnormal_urethra_morphology0.85336749
117MP0005380_embryogenesis_phenotype0.84776833
118MP0001672_abnormal_embryogenesis/_devel0.84776833
119MP0010771_integument_phenotype0.84294742
120MP0005390_skeleton_phenotype0.82628565
121MP0003315_abnormal_perineum_morphology0.82167640
122MP0002092_abnormal_eye_morphology0.81259708
123MP0000747_muscle_weakness0.79915150
124MP0002086_abnormal_extraembryonic_tissu0.79537168
125MP0001879_abnormal_lymphatic_vessel0.79060766
126MP0002108_abnormal_muscle_morphology0.79011963
127MP0001175_abnormal_lung_morphology0.78743097
128MP0004957_abnormal_blastocyst_morpholog0.77958887
129MP0000759_abnormal_skeletal_muscle0.76736920
130MP0003303_peritoneal_inflammation0.76453464
131MP0005375_adipose_tissue_phenotype0.75786201
132MP0001243_abnormal_dermal_layer0.75740380
133MP0000467_abnormal_esophagus_morphology0.75561687
134MP0001542_abnormal_bone_strength0.75490882
135MP0008007_abnormal_cellular_replicative0.75309351
136MP0000627_abnormal_mammary_gland0.73380365
137MP0009931_abnormal_skin_appearance0.68715494
138MP0010234_abnormal_vibrissa_follicle0.66851543
139MP0001881_abnormal_mammary_gland0.64982150
140MP0000566_synostosis0.63569030

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.25356260
2Premature rupture of membranes (HP:0001788)6.24273109
3Anomalous pulmonary venous return (HP:0010772)5.46421501
4Abnormality of the pulmonary veins (HP:0011718)5.05416884
5Shallow orbits (HP:0000586)4.48018395
6Abnormality of glycolipid metabolism (HP:0010969)4.32228510
7Abnormality of liposaccharide metabolism (HP:0010968)4.32228510
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.32228510
9Pseudobulbar signs (HP:0002200)3.98872724
10Hyperacusis (HP:0010780)3.78973292
11Myelomeningocele (HP:0002475)3.50467511
12Axonal loss (HP:0003447)3.32395964
13Genu recurvatum (HP:0002816)3.28375684
14Abnormality of the odontoid process (HP:0003310)3.24259416
15Ankle contracture (HP:0006466)3.21605494
16Vertebral fusion (HP:0002948)3.19043832
17Cerebral aneurysm (HP:0004944)3.18944139
18Increased density of long bones (HP:0006392)3.11968393
19Bladder diverticulum (HP:0000015)3.11641990
20Hemivertebrae (HP:0002937)3.10707014
21Soft skin (HP:0000977)3.07156475
22Dysostosis multiplex (HP:0000943)3.07120637
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99820290
24Atrophic scars (HP:0001075)2.93383489
25Concave nail (HP:0001598)2.91263261
26Increased connective tissue (HP:0009025)2.90295604
27Thin bony cortex (HP:0002753)2.90081095
28Aortic dissection (HP:0002647)2.89257861
29Increased cerebral lipofuscin (HP:0011813)2.85895705
30Distal lower limb muscle weakness (HP:0009053)2.83910028
31Mitral valve prolapse (HP:0001634)2.81608234
32J-shaped sella turcica (HP:0002680)2.76057153
33Fragile skin (HP:0001030)2.75703032
34Neonatal short-limb short stature (HP:0008921)2.68317023
35Wrist flexion contracture (HP:0001239)2.66412378
36Peritonitis (HP:0002586)2.66295665
37Abnormality of dentin (HP:0010299)2.65574586
38Joint stiffness (HP:0001387)2.62905686
39Achilles tendon contracture (HP:0001771)2.59926459
40Bowing of the arm (HP:0006488)2.57548326
41Bowed forearm bones (HP:0003956)2.57548326
42Mesangial abnormality (HP:0001966)2.53792977
43Vacuolated lymphocytes (HP:0001922)2.53747992
44Coronal craniosynostosis (HP:0004440)2.52118465
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.47895454
46Elfin facies (HP:0004428)2.45383594
47Difficulty climbing stairs (HP:0003551)2.44815357
48Broad metatarsal (HP:0001783)2.41375742
49Long toe (HP:0010511)2.41011375
50Abnormality of the lower motor neuron (HP:0002366)2.38493818
51Hyperextensible skin (HP:0000974)2.36535123
52Abnormality of the intervertebral disk (HP:0005108)2.35631631
53Turricephaly (HP:0000262)2.35552361
54Nuclear cataract (HP:0100018)2.33045310
55Dilatation of the ascending aorta (HP:0005111)2.32052442
56Broad face (HP:0000283)2.31367953
57Overriding aorta (HP:0002623)2.28757205
58Spinal rigidity (HP:0003306)2.28193194
59Elbow flexion contracture (HP:0002987)2.24416302
60Blue sclerae (HP:0000592)2.24024163
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23351110
62Abnormality of polysaccharide metabolism (HP:0011012)2.23351110
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23351110
64Insomnia (HP:0100785)2.21533781
65Abnormality of the Achilles tendon (HP:0005109)2.20694874
66Nonimmune hydrops fetalis (HP:0001790)2.20642486
67Abnormality of the distal phalanges of the toes (HP:0010182)2.20605482
68Generalized amyotrophy (HP:0003700)2.20221604
69Distal lower limb amyotrophy (HP:0008944)2.19423733
70Urinary glycosaminoglycan excretion (HP:0003541)2.19235469
71Mucopolysacchariduria (HP:0008155)2.19235469
72Obstructive sleep apnea (HP:0002870)2.19179969
73Hypercortisolism (HP:0001578)2.19134645
74Overgrowth (HP:0001548)2.18866802
75Deviation of the hallux (HP:0010051)2.14988618
76Neonatal respiratory distress (HP:0002643)2.14930664
77Renal duplication (HP:0000075)2.13390718
78Rib fusion (HP:0000902)2.12857311
79Bronchomalacia (HP:0002780)2.11996405
80Hematochezia (HP:0002573)2.11906035
81Ulnar bowing (HP:0003031)2.11638040
82Bowel diverticulosis (HP:0005222)2.10774464
83Prominent occiput (HP:0000269)2.07914121
84Slender long bone (HP:0003100)2.07610452
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07450009
86Short 4th metacarpal (HP:0010044)2.07450009
87Neurofibrillary tangles (HP:0002185)2.05568184
88Hallux valgus (HP:0001822)2.04712306
89Biconcave vertebral bodies (HP:0004586)2.02855002
90Reticulocytopenia (HP:0001896)2.01480409
91Mitral regurgitation (HP:0001653)1.99829216
92Selective tooth agenesis (HP:0001592)1.99043464
93Bulbar palsy (HP:0001283)1.96789645
94Wormian bones (HP:0002645)1.96007011
95Vertebral compression fractures (HP:0002953)1.95855157
96Distal upper limb amyotrophy (HP:0007149)1.93683893
97Upper limb amyotrophy (HP:0009129)1.93683893
98Cervical subluxation (HP:0003308)1.93553718
99Deformed sella turcica (HP:0002681)1.93167782
100Systemic lupus erythematosus (HP:0002725)1.92002003
101Broad distal phalanx of finger (HP:0009836)1.89508689
102Annular pancreas (HP:0001734)1.89364808
103Round ear (HP:0100830)1.88337074
104Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87700163
105Short femoral neck (HP:0100864)1.86170270
106Prolonged neonatal jaundice (HP:0006579)1.86060072
107Disproportionate tall stature (HP:0001519)1.85960071
108Loss of speech (HP:0002371)1.85712230
109Down-sloping shoulders (HP:0200021)1.85233516
110Pathologic fracture (HP:0002756)1.85150949
111Camptodactyly of toe (HP:0001836)1.83486998
112Hyperparathyroidism (HP:0000843)1.83202476
113Facial hemangioma (HP:0000329)1.82712265
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82355434
115Abnormality of the peritoneum (HP:0002585)1.81605590
116Broad toe (HP:0001837)1.81107974
117Shawl scrotum (HP:0000049)1.80899945
118Spina bifida occulta (HP:0003298)1.80774527
119Increased variability in muscle fiber diameter (HP:0003557)1.80707089
120Cerebral inclusion bodies (HP:0100314)1.80076128
121Renovascular hypertension (HP:0100817)1.79567417
122Broad hallux (HP:0010055)1.79270873
123Breech presentation (HP:0001623)1.79178974
124Aortic aneurysm (HP:0004942)1.78844293
125Arnold-Chiari malformation (HP:0002308)1.78674847
126Chin dimple (HP:0010751)1.78265548
127Abdominal distention (HP:0003270)1.78133987
128Hypercalcemia (HP:0003072)1.78015821
129Abnormal delivery (HP:0001787)1.76518334
130Fused cervical vertebrae (HP:0002949)1.76421110
131Spondylolisthesis (HP:0003302)1.76353924
132Natal tooth (HP:0000695)1.75872548
133Aortic regurgitation (HP:0001659)1.75828512
134Abnormality of the thoracic spine (HP:0100711)1.75761873
135Radial bowing (HP:0002986)1.74637321
136Flat cornea (HP:0007720)1.74613578
137Buphthalmos (HP:0000557)1.73725378
138Short nail (HP:0001799)1.73164574
139Sparse lateral eyebrow (HP:0005338)1.73100473
140Mildly elevated creatine phosphokinase (HP:0008180)1.72110021
141Lower limb amyotrophy (HP:0007210)1.71916529
142Congenital glaucoma (HP:0001087)1.71899137
143Thoracic kyphosis (HP:0002942)1.71451181
144Abnormality of the 4th metacarpal (HP:0010012)1.70515629
145Meningocele (HP:0002435)1.69872973
146Multiple lipomas (HP:0001012)1.69823369
147Type 1 muscle fiber predominance (HP:0003803)1.69166619
148Persistence of primary teeth (HP:0006335)1.68944512
149Aplasia/Hypoplasia of the clavicles (HP:0006710)1.68468016
150Focal segmental glomerulosclerosis (HP:0000097)1.68168907
151Aplasia/hypoplasia of the humerus (HP:0006507)1.68104842
152Preaxial foot polydactyly (HP:0001841)1.67724822
153Stridor (HP:0010307)1.67140098
154Entropion (HP:0000621)1.66832867
155Protruding ear (HP:0000411)1.65595128
156Spinal cord compression (HP:0002176)1.65518036
157Femoral bowing (HP:0002980)1.65157897
158Midface retrusion (HP:0011800)1.63102980
159Morphological abnormality of the middle ear (HP:0008609)1.61521702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.44171285
2TLK14.56133158
3LATS23.93080561
4BRD42.92617917
5IRAK32.76480849
6DDR22.70822473
7TRIB32.30188876
8MST1R2.24801521
9PDGFRA2.15899110
10SMG12.05245152
11BMX2.04169066
12EPHB22.02681521
13ICK1.95534820
14ABL21.90162234
15PIM21.84121721
16EPHA21.83633578
17MAP3K61.83152553
18MOS1.80186977
19PKN21.75543759
20MAPKAPK31.63010351
21TTN1.60789020
22MAP3K101.52138669
23TYRO31.48397967
24MAP3K91.44248878
25EEF2K1.43785635
26PAK21.41971883
27DYRK1B1.37991441
28DAPK31.25521686
29TESK21.23155962
30LATS11.21983210
31MKNK21.20431964
32PAK61.17687454
33MUSK1.15225807
34MAP2K21.14271766
35RIPK11.12851670
36STK101.12198668
37CDK91.11176511
38CDK71.09391519
39DYRK31.08572147
40TAOK11.07518394
41MET1.06001164
42MAP2K31.05802546
43PTK21.03898636
44MAP3K31.03641175
45DMPK1.02998823
46CDC42BPA1.02848762
47PRKD21.00904279
48ALK0.94893628
49PRPF4B0.94758019
50NTRK10.94643176
51PDPK10.91523516
52NME20.90613811
53ERN10.88409827
54PRKD30.88169302
55MTOR0.87545409
56PIM10.85702749
57MAP3K110.83433956
58RPS6KC10.83249418
59RPS6KL10.83249418
60UHMK10.82815518
61PTK60.80207446
62LIMK10.79501750
63PTK2B0.78782395
64CDK80.78577786
65CDK60.78392444
66MAPK150.77088551
67FGR0.75937619
68STK110.75807918
69ROCK20.75518071
70LRRK20.75452796
71ILK0.74925870
72PAK40.74371921
73CHUK0.74177172
74PRKG20.73372349
75PAK10.73339809
76ROCK10.73305320
77TBK10.72374716
78ARAF0.68349740
79RPS6KA60.67386584
80NEK20.66951877
81MARK20.61935946
82MAP3K80.59178689
83MELK0.58840503
84HIPK20.56988637
85CAMK2G0.56072693
86RPS6KB20.55866582
87PDK20.54327826
88IKBKB0.54087124
89EPHB10.53170219
90MATK0.53043719
91SIK20.52883413
92AURKA0.52274541
93PNCK0.51757452
94MAP3K10.51618943
95LMTK20.51592439
96IRAK20.51525246
97CAMK2B0.50954684
98TGFBR20.49986024
99KSR20.49953991
100CAMKK10.49862916
101DYRK20.48595169
102CAMK1D0.48457604
103RPS6KA20.47629603
104FER0.46897371
105RPS6KA10.44994357
106BLK0.44924286
107MKNK10.44382902
108PRKD10.43606361
109CSF1R0.43302077
110CDK140.41866946
111MAPKAPK20.40927484
112KDR0.40600729
113TESK10.40072343
114PLK10.39343786
115SCYL20.38953239
116AKT20.37001361
117INSR0.36331947
118GRK60.35951373
119MARK30.35255854
120CDK150.35052072
121PDGFRB0.33865337
122DYRK1A0.33596419
123MAPK90.33594615
124CDK11A0.32012414
125PRKCI0.31672220
126BRAF0.31449390
127CAMK2D0.30388044
128ERBB40.30304045
129MAPK40.30264783
130STK380.29164539
131TAOK20.28685069
132RAF10.28647418
133MAPK120.27992832
134PRKCD0.27452393
135GSK3A0.27384200
136SIK10.27335103
137ADRBK10.25881492

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.02233625
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.04841434
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.90806556
4Lysosome_Homo sapiens_hsa041422.69746116
5Bladder cancer_Homo sapiens_hsa052192.68966399
6Ribosome_Homo sapiens_hsa030102.61937924
7Basal cell carcinoma_Homo sapiens_hsa052172.34300874
8Hippo signaling pathway_Homo sapiens_hsa043902.25220697
9Prion diseases_Homo sapiens_hsa050202.15247946
10Hedgehog signaling pathway_Homo sapiens_hsa043402.12823011
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01716567
12ECM-receptor interaction_Homo sapiens_hsa045122.01518841
13MicroRNAs in cancer_Homo sapiens_hsa052061.91142957
14Vitamin B6 metabolism_Homo sapiens_hsa007501.86720716
15Sulfur relay system_Homo sapiens_hsa041221.84684101
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82977742
17Focal adhesion_Homo sapiens_hsa045101.82596121
18Proteoglycans in cancer_Homo sapiens_hsa052051.81753712
19Adherens junction_Homo sapiens_hsa045201.75439768
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66225243
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66212631
22TGF-beta signaling pathway_Homo sapiens_hsa043501.63923641
23p53 signaling pathway_Homo sapiens_hsa041151.61655433
24Chronic myeloid leukemia_Homo sapiens_hsa052201.55423223
25Axon guidance_Homo sapiens_hsa043601.48449492
26Wnt signaling pathway_Homo sapiens_hsa043101.46753615
27Galactose metabolism_Homo sapiens_hsa000521.40910827
28Small cell lung cancer_Homo sapiens_hsa052221.40744580
29Vibrio cholerae infection_Homo sapiens_hsa051101.39299732
30mTOR signaling pathway_Homo sapiens_hsa041501.38892642
31Glioma_Homo sapiens_hsa052141.36860114
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34969378
33Melanoma_Homo sapiens_hsa052181.33889181
34Melanogenesis_Homo sapiens_hsa049161.32891051
35Colorectal cancer_Homo sapiens_hsa052101.32317520
36Notch signaling pathway_Homo sapiens_hsa043301.32303305
37Systemic lupus erythematosus_Homo sapiens_hsa053221.31214995
38VEGF signaling pathway_Homo sapiens_hsa043701.27845040
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26574402
40Gap junction_Homo sapiens_hsa045401.24856448
41Cell cycle_Homo sapiens_hsa041101.23714132
42HTLV-I infection_Homo sapiens_hsa051661.22458866
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22196448
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21536042
45Spliceosome_Homo sapiens_hsa030401.20371078
46Fructose and mannose metabolism_Homo sapiens_hsa000511.20193376
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18483621
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14965811
49GnRH signaling pathway_Homo sapiens_hsa049121.11999450
50Rap1 signaling pathway_Homo sapiens_hsa040151.10794741
51Amoebiasis_Homo sapiens_hsa051461.10599528
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09651924
53Dilated cardiomyopathy_Homo sapiens_hsa054141.07736604
54Pathways in cancer_Homo sapiens_hsa052001.07608720
55Renal cell carcinoma_Homo sapiens_hsa052111.06456438
56Osteoclast differentiation_Homo sapiens_hsa043801.05505744
57Estrogen signaling pathway_Homo sapiens_hsa049151.04575214
58Alcoholism_Homo sapiens_hsa050341.04486230
59Thyroid cancer_Homo sapiens_hsa052161.03768604
60Tight junction_Homo sapiens_hsa045301.03496139
61Salmonella infection_Homo sapiens_hsa051321.02816580
62HIF-1 signaling pathway_Homo sapiens_hsa040661.00807776
63Endocytosis_Homo sapiens_hsa041441.00395931
64Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00132809
65PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00034851
66ErbB signaling pathway_Homo sapiens_hsa040120.97430859
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94818269
68Viral carcinogenesis_Homo sapiens_hsa052030.93618269
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93360144
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92805586
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.91380423
72Basal transcription factors_Homo sapiens_hsa030220.90022174
73Sphingolipid metabolism_Homo sapiens_hsa006000.89496933
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89088060
75Hepatitis C_Homo sapiens_hsa051600.89010992
76Apoptosis_Homo sapiens_hsa042100.87877254
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87715424
78Non-small cell lung cancer_Homo sapiens_hsa052230.87044403
79Pancreatic cancer_Homo sapiens_hsa052120.86008613
80Synaptic vesicle cycle_Homo sapiens_hsa047210.85559935
81Dorso-ventral axis formation_Homo sapiens_hsa043200.85081141
82RNA polymerase_Homo sapiens_hsa030200.84631433
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84339714
84RNA transport_Homo sapiens_hsa030130.83770997
85Phagosome_Homo sapiens_hsa041450.82953876
86mRNA surveillance pathway_Homo sapiens_hsa030150.82892451
87Protein digestion and absorption_Homo sapiens_hsa049740.81920246
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81362538
89Prostate cancer_Homo sapiens_hsa052150.79285053
90Endometrial cancer_Homo sapiens_hsa052130.79187193
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78646824
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77501825
93Ras signaling pathway_Homo sapiens_hsa040140.74993217
94MAPK signaling pathway_Homo sapiens_hsa040100.73770305
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72566673
96Oocyte meiosis_Homo sapiens_hsa041140.70622336
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70233423
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69252109
99Oxytocin signaling pathway_Homo sapiens_hsa049210.66680341
100Hepatitis B_Homo sapiens_hsa051610.66083554
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65661436
102FoxO signaling pathway_Homo sapiens_hsa040680.64981386
103Base excision repair_Homo sapiens_hsa034100.64962952
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64620702
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63218201
106Pertussis_Homo sapiens_hsa051330.62613895
107Pentose phosphate pathway_Homo sapiens_hsa000300.62017098
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.61664243
109Collecting duct acid secretion_Homo sapiens_hsa049660.61515593
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.60993170
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.59937976
112Acute myeloid leukemia_Homo sapiens_hsa052210.59174595
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58819359
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.57157616
115Viral myocarditis_Homo sapiens_hsa054160.56569770
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55655771
117Arginine and proline metabolism_Homo sapiens_hsa003300.55548855
118Toxoplasmosis_Homo sapiens_hsa051450.55123587
119Shigellosis_Homo sapiens_hsa051310.54936213
120Cocaine addiction_Homo sapiens_hsa050300.54637140
121Malaria_Homo sapiens_hsa051440.53920526
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.53349941
123Long-term depression_Homo sapiens_hsa047300.53242264
124Folate biosynthesis_Homo sapiens_hsa007900.52230516
125AMPK signaling pathway_Homo sapiens_hsa041520.51837181
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51313235
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50212489
128Choline metabolism in cancer_Homo sapiens_hsa052310.50071292
129Prolactin signaling pathway_Homo sapiens_hsa049170.49567711
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48046244
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47913936
132Gastric acid secretion_Homo sapiens_hsa049710.46424584
133Insulin signaling pathway_Homo sapiens_hsa049100.43360121
134Mismatch repair_Homo sapiens_hsa034300.43296098
135TNF signaling pathway_Homo sapiens_hsa046680.42856524
136Nucleotide excision repair_Homo sapiens_hsa034200.42379939

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