IER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.73649009
2negative regulation of cell killing (GO:0031342)5.30887264
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30887264
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76323132
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76323132
6viral transcription (GO:0019083)4.70242986
7translational termination (GO:0006415)4.49781525
8antigen processing and presentation of endogenous antigen (GO:0019883)4.29453348
9DNA deamination (GO:0045006)4.15507031
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04433394
11tolerance induction (GO:0002507)3.93581065
12translational elongation (GO:0006414)3.91717701
13protein targeting to ER (GO:0045047)3.91308444
14cotranslational protein targeting to membrane (GO:0006613)3.88688789
15negative thymic T cell selection (GO:0045060)3.85958397
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.84452256
17maturation of SSU-rRNA (GO:0030490)3.76130559
18negative T cell selection (GO:0043383)3.72313426
19ribosomal small subunit biogenesis (GO:0042274)3.71211984
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66966623
21protein localization to endoplasmic reticulum (GO:0070972)3.63591136
22viral life cycle (GO:0019058)3.61097144
23regulation of B cell receptor signaling pathway (GO:0050855)3.60053232
24response to peptidoglycan (GO:0032494)3.58178202
25regulation of gamma-delta T cell differentiation (GO:0045586)3.53883643
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51151126
27positive regulation by symbiont of host defense response (GO:0052509)3.42721381
28modulation by symbiont of host defense response (GO:0052031)3.42721381
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42721381
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42721381
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.42721381
32modulation by symbiont of host immune response (GO:0052553)3.42721381
33negative regulation of erythrocyte differentiation (GO:0045647)3.40673297
34negative regulation of innate immune response (GO:0045824)3.33884347
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.30379438
36detection of bacterium (GO:0016045)3.29867922
37regulation of T cell mediated cytotoxicity (GO:0001914)3.26663008
383-UTR-mediated mRNA stabilization (GO:0070935)3.26580863
39regulation of interferon-beta biosynthetic process (GO:0045357)3.26310743
40respiratory burst (GO:0045730)3.25182323
41positive T cell selection (GO:0043368)3.23454897
42translational initiation (GO:0006413)3.23450700
43endothelial cell chemotaxis (GO:0035767)3.22706317
44NIK/NF-kappaB signaling (GO:0038061)3.22625621
45cellular protein complex disassembly (GO:0043624)3.22542179
46T cell selection (GO:0045058)3.20916340
47regulation of gamma-delta T cell activation (GO:0046643)3.20343832
48detection of other organism (GO:0098543)3.20062832
49T cell migration (GO:0072678)3.17781452
50cellular response to interleukin-15 (GO:0071350)3.13103299
51positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11279230
52positive regulation of gamma-delta T cell activation (GO:0046645)3.08713829
53negative regulation of leukocyte mediated immunity (GO:0002704)3.08553599
54response to interleukin-15 (GO:0070672)3.08453244
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.08422600
56regulation of natural killer cell mediated immunity (GO:0002715)3.08422600
57neutrophil activation involved in immune response (GO:0002283)3.07738388
58antigen processing and presentation via MHC class Ib (GO:0002475)3.07208117
59response to muramyl dipeptide (GO:0032495)3.06013161
60negative regulation of interleukin-6 production (GO:0032715)3.05345141
61negative regulation of glycoprotein biosynthetic process (GO:0010561)2.97739227
62response to protozoan (GO:0001562)2.95318697
63regulation of leukocyte mediated cytotoxicity (GO:0001910)2.94843870
64macrophage activation involved in immune response (GO:0002281)2.93282974
65negative regulation of T cell mediated immunity (GO:0002710)2.92099844
66response to interferon-beta (GO:0035456)2.90600077
67regulation of B cell differentiation (GO:0045577)2.89973932
68regulation of alpha-beta T cell proliferation (GO:0046640)2.88579001
69protein complex disassembly (GO:0043241)2.87896508
70definitive hemopoiesis (GO:0060216)2.85667934
71mucosal-associated lymphoid tissue development (GO:0048537)2.83949293
72Peyers patch development (GO:0048541)2.83949293
73ribosomal large subunit biogenesis (GO:0042273)2.83269762
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82969632
75regulation of germinal center formation (GO:0002634)2.79609286
76nuclear-transcribed mRNA catabolic process (GO:0000956)2.76500851
77neutrophil activation (GO:0042119)2.75677468
78myeloid cell activation involved in immune response (GO:0002275)2.75212367
79mast cell activation (GO:0045576)2.75168083
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74942150
81regulation of interleukin-12 biosynthetic process (GO:0045075)2.72832457
82leukocyte degranulation (GO:0043299)2.72327816
83cellular response to virus (GO:0098586)2.72218361
84regulation of cell killing (GO:0031341)2.70992241
85granulocyte activation (GO:0036230)2.70735798
86defense response to protozoan (GO:0042832)2.70635395
87germinal center formation (GO:0002467)2.70066760
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69783740
89mRNA catabolic process (GO:0006402)2.69417879
90lymphocyte migration (GO:0072676)2.68408153
91positive thymic T cell selection (GO:0045059)2.68004845
92B cell receptor signaling pathway (GO:0050853)2.66991672
93negative regulation of tumor necrosis factor production (GO:0032720)2.65588822
94macromolecular complex disassembly (GO:0032984)2.64292726
95negative regulation of interleukin-2 production (GO:0032703)2.64032730
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63657038
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62663188
98negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.61873041
99regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.59952251
100regulation of mast cell degranulation (GO:0043304)2.59882181
101positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.58946894
102negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.58804947
103negative regulation of B cell apoptotic process (GO:0002903)2.58088035
104negative regulation of interleukin-8 production (GO:0032717)2.57712952
105regulation of T cell tolerance induction (GO:0002664)2.56956726
106platelet dense granule organization (GO:0060155)2.56404031
107immunoglobulin mediated immune response (GO:0016064)2.56062149
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.56001347
109morphogenesis of an endothelium (GO:0003159)2.55578436
110endothelial tube morphogenesis (GO:0061154)2.55578436
111lymphocyte chemotaxis (GO:0048247)2.53735885
112RNA catabolic process (GO:0006401)2.52911810
113activation of MAPKKK activity (GO:0000185)2.52816749
114leukocyte aggregation (GO:0070486)2.48472767
115B cell mediated immunity (GO:0019724)2.48226066
116hepatocyte apoptotic process (GO:0097284)2.47594535
117protein targeting to membrane (GO:0006612)2.46269210
118proline biosynthetic process (GO:0006561)2.44336949
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.43044374
120regulation of cell proliferation involved in kidney development (GO:1901722)2.42193321
121T cell apoptotic process (GO:0070231)2.41947552
122regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.41815892
123regulation of monocyte differentiation (GO:0045655)2.41807126
124regulation of response to interferon-gamma (GO:0060330)2.40477559
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40245748
126response to type I interferon (GO:0034340)2.40085018
127type I interferon signaling pathway (GO:0060337)2.39425606
128cellular response to type I interferon (GO:0071357)2.39425606
129response to progesterone (GO:0032570)2.39168849
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38948372
131regulation of respiratory burst (GO:0060263)2.36363761
132embryonic process involved in female pregnancy (GO:0060136)2.34754965
133negative regulation of granulocyte differentiation (GO:0030853)2.33004843
134formation of translation preinitiation complex (GO:0001731)2.29534211
135regulation of chemokine secretion (GO:0090196)2.28712246
136chaperone mediated protein folding requiring cofactor (GO:0051085)2.27162207
137ribonucleoprotein complex biogenesis (GO:0022613)2.26605946
138cellular extravasation (GO:0045123)2.25861252
139translation (GO:0006412)2.25368971
140mature B cell differentiation involved in immune response (GO:0002313)2.24438582
141myeloid dendritic cell activation (GO:0001773)2.23517050
142regulation of cellular extravasation (GO:0002691)2.23147605
143regulation of type I interferon-mediated signaling pathway (GO:0060338)2.22890346
144telomere maintenance via semi-conservative replication (GO:0032201)2.22745733
145thymic T cell selection (GO:0045061)2.21874827
146interferon-gamma production (GO:0032609)2.20332530
147positive regulation of B cell differentiation (GO:0045579)2.19865182
148lymphocyte apoptotic process (GO:0070227)2.19387928
149DNA strand elongation involved in DNA replication (GO:0006271)2.17783823
150tyrosine phosphorylation of STAT protein (GO:0007260)2.17493635
151negative regulation of glycoprotein metabolic process (GO:1903019)2.16420477
152interferon-gamma secretion (GO:0072643)2.14695334
153thrombin receptor signaling pathway (GO:0070493)2.14200827
154regulation of necroptotic process (GO:0060544)2.12957790
155dosage compensation (GO:0007549)2.12178081
156tRNA methylation (GO:0030488)2.09828774
157nodal signaling pathway (GO:0038092)2.09595948
158positive regulation of mRNA catabolic process (GO:0061014)2.09024533
159DNA strand elongation (GO:0022616)2.08945787
160response to laminar fluid shear stress (GO:0034616)2.07540135
161megakaryocyte development (GO:0035855)2.07170488
162positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.05891474
163lipopolysaccharide biosynthetic process (GO:0009103)2.05696435
164negative regulation of stress fiber assembly (GO:0051497)2.05308883
165negative regulation of viral entry into host cell (GO:0046597)2.04485490
166regulation of necrotic cell death (GO:0010939)2.03632745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.84863027
2E2F7_22180533_ChIP-Seq_HELA_Human3.72877016
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.52882514
4MYC_22102868_ChIP-Seq_BL_Human2.71610170
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59473103
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.49334238
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.45212638
8* LXR_22292898_ChIP-Seq_THP-1_Human2.33587929
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.32016076
10SCL_19346495_ChIP-Seq_HPC-7_Human2.27877768
11* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.19610758
12VDR_21846776_ChIP-Seq_THP-1_Human2.13252010
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12289884
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07636010
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07007859
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04778339
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95896181
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91188993
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86419682
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83369182
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75661905
22* MAF_26560356_Chip-Seq_TH1_Human1.75537943
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74616248
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73646941
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73646941
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73646941
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70704928
28* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68763231
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.68402982
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.67492749
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66627804
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63090170
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58273793
34* XRN2_22483619_ChIP-Seq_HELA_Human1.57334302
35BCL6_27268052_Chip-Seq_Bcells_Human1.57224722
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.56449306
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56323157
38* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55357110
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55348709
40P68_20966046_ChIP-Seq_HELA_Human1.55068931
41* SPI1_23547873_ChIP-Seq_NB4_Human1.54613086
42* MYB_26560356_Chip-Seq_TH2_Human1.54398457
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53601291
44* UTX_26944678_Chip-Seq_JUKART_Human1.51683541
45* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50217492
46BCOR_27268052_Chip-Seq_Bcells_Human1.48972999
47VDR_24763502_ChIP-Seq_THP-1_Human1.48732898
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48090938
49* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47782011
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46733507
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.46399103
52MYB_26560356_Chip-Seq_TH1_Human1.46380551
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.44114564
54* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43486834
55* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42690209
56* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41787069
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.41413866
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.40258478
59* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39548530
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38839928
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37962094
62* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37835478
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34862802
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34778385
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.33851058
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.33501853
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31164676
68* VDR_23849224_ChIP-Seq_CD4+_Human1.31040342
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30804986
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30169232
71* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27461704
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26981613
73* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26541818
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25960824
75CIITA_25753668_ChIP-Seq_RAJI_Human1.23967963
76RUNX_20019798_ChIP-Seq_JUKART_Human1.23899223
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23480772
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.23466939
79CLOCK_20551151_ChIP-Seq_293T_Human1.22798700
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22612844
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22290325
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.22103945
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21927928
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21828053
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21197973
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19231718
87MAF_26560356_Chip-Seq_TH2_Human1.19156441
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17811384
89SPI1_23127762_ChIP-Seq_K562_Human1.17479970
90TTF2_22483619_ChIP-Seq_HELA_Human1.17367113
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.16712376
92* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16472568
93DCP1A_22483619_ChIP-Seq_HELA_Human1.15677877
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.15550985
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15311566
96* FOXP3_21729870_ChIP-Seq_TREG_Human1.15287870
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14596803
98* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14435724
99* CREB1_26743006_Chip-Seq_LNCaP_Human1.13816975
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13123996
101* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12419941
102* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12054239
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11883184
104SMC4_20622854_ChIP-Seq_HELA_Human1.11729402
105* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11564209
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10918783
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10499406
108* ETS1_20019798_ChIP-Seq_JURKAT_Human1.10027115
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09956867
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08468913
111ZNF263_19887448_ChIP-Seq_K562_Human1.07959456
112* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07586583
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07336913
114* ATF3_27146783_Chip-Seq_COLON_Human1.07296321
115* ESR2_21235772_ChIP-Seq_MCF-7_Human1.06901997
116* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06805270
117* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06735212
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06447113
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06225351
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05631485
121* KDM2B_26808549_Chip-Seq_K562_Human1.05226390
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05089880
123GATA3_27048872_Chip-Seq_THYMUS_Human1.04888407
124* NCOR1_26117541_ChIP-Seq_K562_Human1.04850198
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04641693
126* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03712765
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03075754
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02745251
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02439131
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01721642
131* KDM2B_26808549_Chip-Seq_DND41_Human1.01507394
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01379826
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00952726
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00581856
135RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00103354
136GATA1_19941826_ChIP-Seq_K562_Human0.99898264
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99764364
138RACK7_27058665_Chip-Seq_MCF-7_Human0.98407381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to2.94325797
2MP0003763_abnormal_thymus_physiology2.62943847
3MP0009278_abnormal_bone_marrow2.37445301
4MP0003436_decreased_susceptibility_to2.33206302
5MP0000685_abnormal_immune_system2.32801900
6MP0002396_abnormal_hematopoietic_system2.16570790
7MP0004808_abnormal_hematopoietic_stem2.11928221
8MP0001873_stomach_inflammation2.11570173
9MP0001853_heart_inflammation2.09416070
10MP0001835_abnormal_antigen_presentation2.04542823
11MP0010352_gastrointestinal_tract_polyps1.99599699
12MP0005671_abnormal_response_to1.93696895
13MP0010155_abnormal_intestine_physiology1.93349453
14MP0002405_respiratory_system_inflammati1.90995469
15MP0001545_abnormal_hematopoietic_system1.87710466
16MP0005397_hematopoietic_system_phenotyp1.87710466
17MP0009785_altered_susceptibility_to1.83674712
18MP0001800_abnormal_humoral_immune1.82968214
19MP0000490_abnormal_crypts_of1.79938944
20MP0005000_abnormal_immune_tolerance1.78662657
21MP0003693_abnormal_embryo_hatching1.72518317
22MP0002452_abnormal_antigen_presenting1.70209901
23MP0000465_gastrointestinal_hemorrhage1.70195332
24MP0002166_altered_tumor_susceptibility1.69180161
25MP0002723_abnormal_immune_serum1.69053156
26MP0005025_abnormal_response_to1.67909854
27MP0002420_abnormal_adaptive_immunity1.67422564
28MP0002398_abnormal_bone_marrow1.65915752
29MP0001819_abnormal_immune_cell1.64924523
30MP0003300_gastrointestinal_ulcer1.64330099
31MP0001986_abnormal_taste_sensitivity1.64180971
32MP0008007_abnormal_cellular_replicative1.59773306
33MP0004947_skin_inflammation1.58797407
34MP0009333_abnormal_splenocyte_physiolog1.57541489
35MP0002148_abnormal_hypersensitivity_rea1.55297466
36MP0001790_abnormal_immune_system1.55089704
37MP0005387_immune_system_phenotype1.55089704
38MP0002254_reproductive_system_inflammat1.54001294
39MP0002722_abnormal_immune_system1.52919878
40MP0002132_abnormal_respiratory_system1.52502485
41MP0003828_pulmonary_edema1.51833121
42MP0002877_abnormal_melanocyte_morpholog1.49662650
43MP0003866_abnormal_defecation1.48533174
44MP0005023_abnormal_wound_healing1.47969008
45MP0002419_abnormal_innate_immunity1.46758238
46MP0000703_abnormal_thymus_morphology1.46275986
47MP0000689_abnormal_spleen_morphology1.44837668
48MP0005464_abnormal_platelet_physiology1.43086328
49MP0000716_abnormal_immune_system1.42928396
50MP0005083_abnormal_biliary_tract1.42193531
51MP0003303_peritoneal_inflammation1.42164730
52MP0008260_abnormal_autophagy1.40885937
53MP0005058_abnormal_lysosome_morphology1.40630825
54MP0001851_eye_inflammation1.40211614
55MP0000858_altered_metastatic_potential1.38466414
56MP0002933_joint_inflammation1.35440853
57MP0003453_abnormal_keratinocyte_physiol1.32720891
58MP0002429_abnormal_blood_cell1.32639683
59MP0002998_abnormal_bone_remodeling1.32401109
60MP0004510_myositis1.30398940
61MP0001533_abnormal_skeleton_physiology1.30306105
62MP0001845_abnormal_inflammatory_respons1.29327921
63MP0002006_tumorigenesis1.29015037
64MP0006054_spinal_hemorrhage1.21122849
65MP0002138_abnormal_hepatobiliary_system1.18551127
66MP0003566_abnormal_cell_adhesion1.17221783
67MP0003077_abnormal_cell_cycle1.13231542
68MP0010368_abnormal_lymphatic_system1.11201139
69MP0005174_abnormal_tail_pigmentation1.10041655
70MP0005166_decreased_susceptibility_to1.09028809
71MP0005075_abnormal_melanosome_morpholog1.09022827
72MP0009379_abnormal_foot_pigmentation1.07561787
73MP0002060_abnormal_skin_morphology1.06615392
74MP0009764_decreased_sensitivity_to1.05702753
75MP0005390_skeleton_phenotype1.03870065
76MP0004957_abnormal_blastocyst_morpholog1.03427773
77MP0009840_abnormal_foam_cell1.03139432
78MP0006082_CNS_inflammation1.00834663
79MP0003279_aneurysm0.99910836
80MP0003448_altered_tumor_morphology0.98378678
81MP0002019_abnormal_tumor_incidence0.96863866
82MP0003943_abnormal_hepatobiliary_system0.96311808
83MP0002928_abnormal_bile_duct0.95897920
84MP0000613_abnormal_salivary_gland0.91684925
85MP0008469_abnormal_protein_level0.90625356
86MP0003075_altered_response_to0.90300797
87MP0000678_abnormal_parathyroid_gland0.89652417
88MP0000477_abnormal_intestine_morphology0.89303683
89MP0005220_abnormal_exocrine_pancreas0.88490070
90MP0008058_abnormal_DNA_repair0.88299618
91MP0010094_abnormal_chromosome_stability0.86937579
92MP0002009_preneoplasia0.85812319
93MP0004381_abnormal_hair_follicle0.84905535
94MP0003172_abnormal_lysosome_physiology0.84013309
95MP0004264_abnormal_extraembryonic_tissu0.83960846
96MP0005076_abnormal_cell_differentiation0.81801683
97MP0001502_abnormal_circadian_rhythm0.80526677
98MP0005377_hearing/vestibular/ear_phenot0.79782063
99MP0003878_abnormal_ear_physiology0.79782063
100MP0009763_increased_sensitivity_to0.78573430
101MP0008004_abnormal_stomach_pH0.78076684
102MP0001216_abnormal_epidermal_layer0.78053597
103MP0000343_altered_response_to0.78035475
104MP0002277_abnormal_respiratory_mucosa0.76832038
105MP0003786_premature_aging0.76656332
106MP0001243_abnormal_dermal_layer0.76408199
107MP0008961_abnormal_basal_metabolism0.76304602
108MP0000249_abnormal_blood_vessel0.75416465
109MP0001348_abnormal_lacrimal_gland0.73988911
110MP0001663_abnormal_digestive_system0.73966862
111MP0009931_abnormal_skin_appearance0.73958107
112MP0005310_abnormal_salivary_gland0.73811223
113MP0000350_abnormal_cell_proliferation0.73537846
114MP0000313_abnormal_cell_death0.72616214
115MP0001542_abnormal_bone_strength0.72571125
116MP0001881_abnormal_mammary_gland0.71147682
117MP0002796_impaired_skin_barrier0.71122230
118MP0003191_abnormal_cellular_cholesterol0.68928121
119MP0005164_abnormal_response_to0.68713658
120MP0003795_abnormal_bone_structure0.67211647
121MP0010030_abnormal_orbit_morphology0.66872065
122MP0001879_abnormal_lymphatic_vessel0.66855279
123MP0005423_abnormal_somatic_nervous0.60814971
124MP0005334_abnormal_fat_pad0.60133695
125MP0009765_abnormal_xenobiotic_induced0.59397303
126MP0008873_increased_physiological_sensi0.57619399
127MP0003045_fibrosis0.57462221
128MP0002136_abnormal_kidney_physiology0.57280671
129MP0004883_abnormal_blood_vessel0.54864120

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.23274983
2Thrombocytosis (HP:0001894)4.07544496
3Abnormality of macrophages (HP:0004311)4.05286192
4Agammaglobulinemia (HP:0004432)3.92271565
5Reticulocytopenia (HP:0001896)3.58170499
6Abnormality of cells of the erythroid lineage (HP:0012130)3.57008707
7IgM deficiency (HP:0002850)3.44851950
8Abnormal number of erythroid precursors (HP:0012131)3.37611557
9Obstructive lung disease (HP:0006536)3.36199640
10Chronic obstructive pulmonary disease (HP:0006510)3.36199640
11Chronic otitis media (HP:0000389)3.34979230
12Eczematoid dermatitis (HP:0000976)3.29531846
13Aplastic anemia (HP:0001915)3.25706711
14Recurrent gram-negative bacterial infections (HP:0005420)3.25163512
15Myositis (HP:0100614)3.24717407
16Gastrointestinal infarctions (HP:0005244)3.22636813
17Petechiae (HP:0000967)3.18322707
18Encephalitis (HP:0002383)3.05605220
19Stomach cancer (HP:0012126)3.04695301
20Prolonged bleeding time (HP:0003010)3.00927653
21Abnormality of the nasal mucosa (HP:0000433)2.97297798
22Increased IgM level (HP:0003496)2.90411154
23Granulocytopenia (HP:0001913)2.89098070
24Pustule (HP:0200039)2.86585271
25Urticaria (HP:0001025)2.77304651
26Broad face (HP:0000283)2.65788848
27Hypergammaglobulinemia (HP:0010702)2.63269884
28Abnormality of T cell physiology (HP:0011840)2.62616758
29Keratoconjunctivitis sicca (HP:0001097)2.61632272
30Nasal polyposis (HP:0100582)2.61008094
31Pulmonary infiltrates (HP:0002113)2.58468368
32IgG deficiency (HP:0004315)2.56828155
33T lymphocytopenia (HP:0005403)2.55130704
34Verrucae (HP:0200043)2.54142706
35Papilloma (HP:0012740)2.54142706
36Keratoconjunctivitis (HP:0001096)2.53747817
37Abnormality of T cell number (HP:0011839)2.53218327
38Pallor (HP:0000980)2.52746239
39Recurrent fungal infections (HP:0002841)2.49038568
40Hypertensive crisis (HP:0100735)2.48440554
41Impaired platelet aggregation (HP:0003540)2.48332778
42Abnormal platelet function (HP:0011869)2.48332778
43Recurrent bronchitis (HP:0002837)2.48151858
44Severe combined immunodeficiency (HP:0004430)2.47190508
45Conical tooth (HP:0000698)2.46667497
46Eosinophilia (HP:0001880)2.45260620
47Gastrointestinal inflammation (HP:0004386)2.45193503
48Type I transferrin isoform profile (HP:0003642)2.44765301
49Spontaneous hematomas (HP:0007420)2.43936719
50Inflammation of the large intestine (HP:0002037)2.39974029
51Increased serum ferritin (HP:0003281)2.39818148
52Epistaxis (HP:0000421)2.39240833
53Osteomyelitis (HP:0002754)2.38898526
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.35238222
55Abnormality of the fingertips (HP:0001211)2.35021346
56Orchitis (HP:0100796)2.33877101
5711 pairs of ribs (HP:0000878)2.33540566
58Interstitial pulmonary disease (HP:0006530)2.32703647
59Abnormality of eosinophils (HP:0001879)2.32549923
60Recurrent abscess formation (HP:0002722)2.31633895
61Cheilitis (HP:0100825)2.31224545
62Sepsis (HP:0100806)2.29081919
63Poikiloderma (HP:0001029)2.27762913
64Hypertriglyceridemia (HP:0002155)2.26425861
65Abnormality of T cells (HP:0002843)2.24989617
66Episodic fever (HP:0001954)2.23858441
67Trismus (HP:0000211)2.22600161
68Hemorrhage of the eye (HP:0011885)2.20027307
69Gastrointestinal stroma tumor (HP:0100723)2.19179696
70Amaurosis fugax (HP:0100576)2.18373452
71Abnormality of the columella (HP:0009929)2.18324904
72Segmental peripheral demyelination/remyelination (HP:0003481)2.17957507
73Macrocytic anemia (HP:0001972)2.16141745
74Periodontitis (HP:0000704)2.15482197
75Growth hormone excess (HP:0000845)2.14984402
76Autoimmune thrombocytopenia (HP:0001973)2.14824922
77Anorexia (HP:0002039)2.13402422
78Glomerulopathy (HP:0100820)2.11539105
79Tetany (HP:0001281)2.11057198
80Hematochezia (HP:0002573)2.10720610
81Joint swelling (HP:0001386)2.07369849
82Obstructive sleep apnea (HP:0002870)2.04541312
83Panhypogammaglobulinemia (HP:0003139)2.04056850
84Colon cancer (HP:0003003)2.03711032
85Skin rash (HP:0000988)2.03442686
86Abnormality of the pleura (HP:0002103)2.03237241
87Gingival bleeding (HP:0000225)2.01954553
88Reduced antithrombin III activity (HP:0001976)2.00706762
89Lymphoma (HP:0002665)1.99296115
90Keratitis (HP:0000491)1.98384670
91Autoimmune hemolytic anemia (HP:0001890)1.97346449
92Recurrent bacterial skin infections (HP:0005406)1.97231783
93Vacuolated lymphocytes (HP:0001922)1.96488026
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95816585
95Selective tooth agenesis (HP:0001592)1.95763726
96Microretrognathia (HP:0000308)1.95509117
97Cellulitis (HP:0100658)1.94764332
98Abnormal protein glycosylation (HP:0012346)1.92795898
99Abnormal glycosylation (HP:0012345)1.92795898
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92795898
101Abnormal protein N-linked glycosylation (HP:0012347)1.92795898
102Hypochromic anemia (HP:0001931)1.92116982
103Gangrene (HP:0100758)1.92035739
104Fatigue (HP:0012378)1.91795815
105Seborrheic dermatitis (HP:0001051)1.90859864
106Recurrent cutaneous fungal infections (HP:0011370)1.90057967
107Chronic mucocutaneous candidiasis (HP:0002728)1.90057967
108Alveolar cell carcinoma (HP:0006519)1.89558709
109Hepatosplenomegaly (HP:0001433)1.87962742
110Stomatitis (HP:0010280)1.87517287
111Mediastinal lymphadenopathy (HP:0100721)1.86498672
112Amyloidosis (HP:0011034)1.86222843
113Dysostosis multiplex (HP:0000943)1.84952951
114Protrusio acetabuli (HP:0003179)1.82647826
115Oral leukoplakia (HP:0002745)1.82139632
116Abnormal hemoglobin (HP:0011902)1.81624453
117Arthralgia (HP:0002829)1.81506055
118Recurrent lower respiratory tract infections (HP:0002783)1.80171012
119Prostate neoplasm (HP:0100787)1.79533529
120Milia (HP:0001056)1.79213117
121Purpura (HP:0000979)1.78221231
122Hemoptysis (HP:0002105)1.77238630
123Skin ulcer (HP:0200042)1.77024256
124Increased IgE level (HP:0003212)1.74198507
125Colitis (HP:0002583)1.73656836
126Abnormal platelet volume (HP:0011876)1.73464624
127Leukocytosis (HP:0001974)1.72998835
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.71772012
129Myelodysplasia (HP:0002863)1.70656631
130Microcytic anemia (HP:0001935)1.70630182
131Recurrent viral infections (HP:0004429)1.69926803
132Emphysema (HP:0002097)1.68891951
133Menorrhagia (HP:0000132)1.67640035
134Recurrent skin infections (HP:0001581)1.67427628
135Muscle fiber atrophy (HP:0100295)1.67245956
136Lymphopenia (HP:0001888)1.65964574
137Asplenia (HP:0001746)1.65952289
138Nonimmune hydrops fetalis (HP:0001790)1.64653395
139Retrobulbar optic neuritis (HP:0100654)1.62558210
140Optic neuritis (HP:0100653)1.62558210
141Increased density of long bones (HP:0006392)1.61966009
142Gingivitis (HP:0000230)1.61755798
143Pancytopenia (HP:0001876)1.61620164
144Arterial thrombosis (HP:0004420)1.61501282
145Meningitis (HP:0001287)1.61157225
146Vasculitis (HP:0002633)1.55406503
147Basal cell carcinoma (HP:0002671)1.55171301
148Cerebral aneurysm (HP:0004944)1.54872166
149Vertebral compression fractures (HP:0002953)1.53749830
150Neoplasm of the pancreas (HP:0002894)1.53437926
151Aplasia/Hypoplasia of the spleen (HP:0010451)1.52385441
152Bruising susceptibility (HP:0000978)1.51602085
153Fragile skin (HP:0001030)1.50759603
154Chest pain (HP:0100749)1.49858684
155Esophageal varix (HP:0002040)1.47704072
156Increased mean platelet volume (HP:0011877)1.47021993
157Absent thumb (HP:0009777)1.46762650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.33143985
2MAP4K13.27114685
3KDR2.39903187
4PIM22.37036270
5ERN12.26896805
6TGFBR22.25540302
7MAP2K22.24252583
8PRPF4B2.10486505
9ZAP701.94106428
10EEF2K1.89217201
11NME21.88776940
12RIPK41.79869715
13MAP2K31.77697526
14TBK11.76518106
15MAP3K101.74986573
16MAP3K111.73070766
17SIK21.70854130
18RPS6KB21.70486124
19TXK1.69865642
20JAK31.66539674
21TIE11.63853441
22IKBKB1.63604894
23VRK11.61907860
24FES1.59728493
25BTK1.58292832
26RPS6KA41.57116870
27TGFBR11.56860864
28STK101.53343119
29KIT1.53121212
30IKBKE1.52769515
31TSSK61.52576009
32MAPKAPK31.51492978
33MAP3K31.51404290
34SIK11.50386802
35NLK1.49533403
36TYK21.48605012
37MAP3K141.48248689
38TEC1.47769677
39EPHA21.41497815
40DYRK31.40158462
41FLT31.39087405
42IRAK41.33874409
43PASK1.28663710
44TAOK31.27943935
45FGFR41.22354924
46SMG11.21858095
47CHUK1.21091422
48SIK31.20278640
49PIM11.19245097
50PAK41.15601376
51TNK21.14368437
52BLK1.13368275
53PRKD21.13348258
54TRIB31.09856197
55MAPK71.09476938
56ITK1.09188194
57RIPK11.07866073
58IRAK31.06428561
59TESK21.02545988
60MAP3K131.00147786
61LRRK20.99494436
62PIK3CG0.97241810
63EPHA30.96960727
64PKN20.96104622
65RPS6KA20.93319677
66CDK70.92086890
67MAP3K10.91187983
68CSK0.90825359
69EPHB10.89874136
70MATK0.89557880
71CDK120.89488286
72MAP2K60.89310078
73WEE10.89003469
74HIPK20.88162627
75RPS6KA50.85875370
76TLK10.85679185
77IRAK10.84253060
78GRK60.83389468
79ICK0.79559769
80RPS6KA60.77549934
81MST40.77299560
82MARK20.76973733
83PRKG20.76698879
84MAPKAPK20.74324664
85BCKDK0.70306417
86TAOK20.69900090
87MARK30.69534396
88LCK0.69515713
89STK160.68990784
90MAPK120.68957368
91PTK60.67060137
92RPS6KC10.66251426
93RPS6KL10.66251426
94PDK20.65358959
95PDPK10.63773356
96NEK20.60821558
97CSF1R0.59719540
98ABL20.58551943
99PAK20.56507890
100MAPK110.56360061
101BRD40.55280293
102RPS6KA10.53420671
103PDK10.53253971
104CDK80.52948940
105HCK0.52558133
106MAPKAPK50.52489243
107CDK90.50073950
108MAPK40.49611530
109VRK20.49271378
110PRKCQ0.47576223
111JAK20.47335298
112MAP3K80.46702653
113IRAK20.46160233
114MAP3K70.45915662
115CDK40.45311444
116SYK0.44901009
117ACVR1B0.44678619
118CLK10.44641985
119LYN0.44036409
120TAOK10.43661120
121CDK60.43547193
122BMPR20.43225774
123PRKD10.42986529
124CDC42BPA0.42556755
125MAP3K60.41558170
126TESK10.41159184
127JAK10.39826146
128EIF2AK30.39583511
129DYRK1B0.39394371
130BUB10.39289526
131MAPK30.38444149
132AURKB0.38384736
133RAF10.36574228
134FGR0.34302007
135MTOR0.34031544

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.57298397
2DNA replication_Homo sapiens_hsa030302.64818009
3Autoimmune thyroid disease_Homo sapiens_hsa053202.26177351
4Leishmaniasis_Homo sapiens_hsa051402.17572351
5Mismatch repair_Homo sapiens_hsa034302.15189249
6Primary immunodeficiency_Homo sapiens_hsa053401.95460792
7Spliceosome_Homo sapiens_hsa030401.93220450
8Antigen processing and presentation_Homo sapiens_hsa046121.92028368
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.90556165
10Base excision repair_Homo sapiens_hsa034101.83406203
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78777284
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76607368
13Osteoclast differentiation_Homo sapiens_hsa043801.68233142
14Herpes simplex infection_Homo sapiens_hsa051681.63960223
15Legionellosis_Homo sapiens_hsa051341.54446288
16Measles_Homo sapiens_hsa051621.53413303
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.52514452
18TNF signaling pathway_Homo sapiens_hsa046681.49836063
19Type I diabetes mellitus_Homo sapiens_hsa049401.45964419
20p53 signaling pathway_Homo sapiens_hsa041151.41470684
21Apoptosis_Homo sapiens_hsa042101.38760294
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38725325
23Folate biosynthesis_Homo sapiens_hsa007901.37887983
24Toxoplasmosis_Homo sapiens_hsa051451.36435202
25Acute myeloid leukemia_Homo sapiens_hsa052211.34623139
26Homologous recombination_Homo sapiens_hsa034401.33928499
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32090475
28Notch signaling pathway_Homo sapiens_hsa043301.31953240
29B cell receptor signaling pathway_Homo sapiens_hsa046621.31905548
30RNA polymerase_Homo sapiens_hsa030201.29414492
31Hematopoietic cell lineage_Homo sapiens_hsa046401.28984743
32Other glycan degradation_Homo sapiens_hsa005111.26681898
33T cell receptor signaling pathway_Homo sapiens_hsa046601.26581672
34Pyrimidine metabolism_Homo sapiens_hsa002401.26327534
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.25088745
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24298649
37Sulfur relay system_Homo sapiens_hsa041221.24067683
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.23295963
39Influenza A_Homo sapiens_hsa051641.21127950
40Hepatitis B_Homo sapiens_hsa051611.19716501
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.18663819
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16295948
43HTLV-I infection_Homo sapiens_hsa051661.15633868
44Chemokine signaling pathway_Homo sapiens_hsa040621.15529210
45Pertussis_Homo sapiens_hsa051331.14483592
46Rheumatoid arthritis_Homo sapiens_hsa053231.14057377
47Nucleotide excision repair_Homo sapiens_hsa034201.11703260
48Shigellosis_Homo sapiens_hsa051311.11397043
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10918924
50Epstein-Barr virus infection_Homo sapiens_hsa051691.10000957
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07500284
52Small cell lung cancer_Homo sapiens_hsa052221.05322811
53One carbon pool by folate_Homo sapiens_hsa006701.04863338
54Protein export_Homo sapiens_hsa030601.04200336
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01962687
56RNA degradation_Homo sapiens_hsa030180.97554133
57Chronic myeloid leukemia_Homo sapiens_hsa052200.96192952
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93144906
59Cell cycle_Homo sapiens_hsa041100.91629277
60VEGF signaling pathway_Homo sapiens_hsa043700.90158635
61RNA transport_Homo sapiens_hsa030130.90097955
62Viral carcinogenesis_Homo sapiens_hsa052030.89430740
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87744242
64Proteasome_Homo sapiens_hsa030500.86366307
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85963775
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85600365
67Malaria_Homo sapiens_hsa051440.84409029
68Asthma_Homo sapiens_hsa053100.84119784
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82683912
70African trypanosomiasis_Homo sapiens_hsa051430.82154765
71Colorectal cancer_Homo sapiens_hsa052100.81668716
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80235976
73MAPK signaling pathway_Homo sapiens_hsa040100.76867028
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.76031694
75Endocytosis_Homo sapiens_hsa041440.75094413
76Prolactin signaling pathway_Homo sapiens_hsa049170.74386366
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.74199352
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.74151613
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73518303
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.73311866
81Hepatitis C_Homo sapiens_hsa051600.72620696
82Bladder cancer_Homo sapiens_hsa052190.70366554
83Thyroid cancer_Homo sapiens_hsa052160.69916627
84N-Glycan biosynthesis_Homo sapiens_hsa005100.69426167
85Selenocompound metabolism_Homo sapiens_hsa004500.69422555
86Platelet activation_Homo sapiens_hsa046110.68084264
87Fanconi anemia pathway_Homo sapiens_hsa034600.67886305
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66784207
89Salmonella infection_Homo sapiens_hsa051320.64978057
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63265345
91Phagosome_Homo sapiens_hsa041450.63232854
92Galactose metabolism_Homo sapiens_hsa000520.62649964
93Non-small cell lung cancer_Homo sapiens_hsa052230.62614917
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62135916
95Allograft rejection_Homo sapiens_hsa053300.61220581
96Staphylococcus aureus infection_Homo sapiens_hsa051500.59797903
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59460264
98Graft-versus-host disease_Homo sapiens_hsa053320.58018621
99Non-homologous end-joining_Homo sapiens_hsa034500.57505074
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55297281
101Lysosome_Homo sapiens_hsa041420.54732220
102Pathways in cancer_Homo sapiens_hsa052000.53714987
103Insulin resistance_Homo sapiens_hsa049310.53591477
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50119586
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49721983
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48706017
107FoxO signaling pathway_Homo sapiens_hsa040680.48219240
108Systemic lupus erythematosus_Homo sapiens_hsa053220.48032951
109Prion diseases_Homo sapiens_hsa050200.47901502
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46814847
111Pancreatic cancer_Homo sapiens_hsa052120.45981173
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45942358
113Tuberculosis_Homo sapiens_hsa051520.44611922
114Viral myocarditis_Homo sapiens_hsa054160.44384027
115Renal cell carcinoma_Homo sapiens_hsa052110.44085770
116Protein digestion and absorption_Homo sapiens_hsa049740.42803967
117Choline metabolism in cancer_Homo sapiens_hsa052310.42736133
118Basal transcription factors_Homo sapiens_hsa030220.42103369
119TGF-beta signaling pathway_Homo sapiens_hsa043500.42079729
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41980451
121ECM-receptor interaction_Homo sapiens_hsa045120.41753284
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38106002
123Fructose and mannose metabolism_Homo sapiens_hsa000510.34072502
124Prostate cancer_Homo sapiens_hsa052150.33793226
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.32678963
126ErbB signaling pathway_Homo sapiens_hsa040120.32103198
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.31938507
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.30432630
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28136061
130GnRH signaling pathway_Homo sapiens_hsa049120.28086088
131Amoebiasis_Homo sapiens_hsa051460.27600007
132HIF-1 signaling pathway_Homo sapiens_hsa040660.23933790
133mTOR signaling pathway_Homo sapiens_hsa041500.23250618
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.22065207
135Regulation of autophagy_Homo sapiens_hsa041400.21848058

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