IDH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.13482367
2L-phenylalanine catabolic process (GO:0006559)6.13482367
3L-phenylalanine metabolic process (GO:0006558)5.75180266
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75180266
5alpha-linolenic acid metabolic process (GO:0036109)5.51102602
6aromatic amino acid family catabolic process (GO:0009074)5.47313325
7* glyoxylate metabolic process (GO:0046487)5.21479220
8bile acid biosynthetic process (GO:0006699)5.10782349
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.08485206
10L-serine metabolic process (GO:0006563)5.00084523
11sulfur amino acid catabolic process (GO:0000098)4.99606822
12tryptophan catabolic process (GO:0006569)4.84581566
13indole-containing compound catabolic process (GO:0042436)4.84581566
14indolalkylamine catabolic process (GO:0046218)4.84581566
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66838647
16tryptophan metabolic process (GO:0006568)4.65776592
17cysteine metabolic process (GO:0006534)4.62358659
18cellular glucuronidation (GO:0052695)4.55856355
19epoxygenase P450 pathway (GO:0019373)4.55594115
20pyrimidine nucleobase catabolic process (GO:0006208)4.53659719
21high-density lipoprotein particle remodeling (GO:0034375)4.50111169
22complement activation, alternative pathway (GO:0006957)4.49039934
23kynurenine metabolic process (GO:0070189)4.48975860
24urea cycle (GO:0000050)4.44045685
25urea metabolic process (GO:0019627)4.44045685
26glucuronate metabolic process (GO:0019585)4.43597559
27uronic acid metabolic process (GO:0006063)4.43597559
28protein carboxylation (GO:0018214)4.41291169
29peptidyl-glutamic acid carboxylation (GO:0017187)4.41291169
30cellular ketone body metabolic process (GO:0046950)4.32035174
31benzene-containing compound metabolic process (GO:0042537)4.30690706
32cholesterol biosynthetic process (GO:0006695)4.28746241
33bile acid metabolic process (GO:0008206)4.28620722
34aldehyde catabolic process (GO:0046185)4.26422240
35nitrogen cycle metabolic process (GO:0071941)4.14922970
36acetyl-CoA metabolic process (GO:0006084)4.14807284
37regulation of cholesterol esterification (GO:0010872)4.13608588
38regulation of triglyceride catabolic process (GO:0010896)4.12050938
39estrogen biosynthetic process (GO:0006703)4.11478202
40plasma lipoprotein particle clearance (GO:0034381)4.10474556
41regulation of protein activation cascade (GO:2000257)4.06719333
42plasma lipoprotein particle remodeling (GO:0034369)4.06299913
43protein-lipid complex remodeling (GO:0034368)4.06299913
44macromolecular complex remodeling (GO:0034367)4.06299913
45negative regulation of fibrinolysis (GO:0051918)4.06288301
46reverse cholesterol transport (GO:0043691)4.05466391
47tyrosine metabolic process (GO:0006570)4.04371663
48homocysteine metabolic process (GO:0050667)4.01613233
49very-low-density lipoprotein particle assembly (GO:0034379)4.01497027
50lysine catabolic process (GO:0006554)4.01217119
51lysine metabolic process (GO:0006553)4.01217119
52nucleobase catabolic process (GO:0046113)3.98063543
53chromatin remodeling at centromere (GO:0031055)3.95759877
54aromatic amino acid family metabolic process (GO:0009072)3.95344115
55ethanol oxidation (GO:0006069)3.92737130
56serine family amino acid catabolic process (GO:0009071)3.92476917
57cholesterol efflux (GO:0033344)3.88729103
58establishment of integrated proviral latency (GO:0075713)3.88002850
59amino-acid betaine metabolic process (GO:0006577)3.87918186
60regulation of fibrinolysis (GO:0051917)3.87534441
61regulation of complement activation (GO:0030449)3.84223852
62CENP-A containing nucleosome assembly (GO:0034080)3.79435590
63very long-chain fatty acid metabolic process (GO:0000038)3.78254381
64xenobiotic catabolic process (GO:0042178)3.78169308
65coenzyme catabolic process (GO:0009109)3.77673744
66ketone body metabolic process (GO:1902224)3.74822372
67sterol biosynthetic process (GO:0016126)3.74321094
68DNA double-strand break processing (GO:0000729)3.74022989
69acylglycerol homeostasis (GO:0055090)3.70604030
70triglyceride homeostasis (GO:0070328)3.70604030
71drug catabolic process (GO:0042737)3.68905715
72response to phenylpropanoid (GO:0080184)3.68822490
73alpha-amino acid catabolic process (GO:1901606)3.67720691
74response to nitrosative stress (GO:0051409)3.65645737
75phospholipid efflux (GO:0033700)3.64112520
76fatty acid beta-oxidation (GO:0006635)3.61794531
77short-chain fatty acid metabolic process (GO:0046459)3.60467827
78regulation of cholesterol metabolic process (GO:0090181)3.59979224
79serine family amino acid biosynthetic process (GO:0009070)3.59015772
80low-density lipoprotein particle remodeling (GO:0034374)3.57866741
81fatty acid elongation (GO:0030497)3.57436850
82cellular amino acid catabolic process (GO:0009063)3.56572992
83fatty-acyl-CoA biosynthetic process (GO:0046949)3.54949345
84drug transmembrane transport (GO:0006855)3.53162910
85fatty acid oxidation (GO:0019395)3.52055921
86plasma lipoprotein particle assembly (GO:0034377)3.51994330
87indolalkylamine metabolic process (GO:0006586)3.51140510
88phenylpropanoid metabolic process (GO:0009698)3.49947034
89negative regulation of cholesterol transport (GO:0032375)3.48119548
90negative regulation of sterol transport (GO:0032372)3.48119548
91lipid oxidation (GO:0034440)3.47630924
92urate metabolic process (GO:0046415)3.47527160
93anterior/posterior axis specification, embryo (GO:0008595)3.47375419
94amine catabolic process (GO:0009310)3.46504715
95cellular biogenic amine catabolic process (GO:0042402)3.46504715
96cholesterol homeostasis (GO:0042632)3.46262338
97phospholipid homeostasis (GO:0055091)3.45216698
98acyl-CoA metabolic process (GO:0006637)3.44716176
99thioester metabolic process (GO:0035383)3.44716176
100fatty acid catabolic process (GO:0009062)3.44478878
101monocarboxylic acid catabolic process (GO:0072329)3.44295219
102long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.43827922
103positive regulation of lipid catabolic process (GO:0050996)3.42312098
104cellular modified amino acid catabolic process (GO:0042219)3.42214812
105sterol homeostasis (GO:0055092)3.41791522
106flavonoid metabolic process (GO:0009812)3.39832254
107histone exchange (GO:0043486)3.38827418
108organic acid catabolic process (GO:0016054)3.37596123
109IMP biosynthetic process (GO:0006188)3.34690262
110mitotic metaphase plate congression (GO:0007080)3.28211131
111protein localization to kinetochore (GO:0034501)3.25688793
112purine nucleobase biosynthetic process (GO:0009113)3.20465212
113DNA replication-independent nucleosome assembly (GO:0006336)3.19328616
114DNA replication-independent nucleosome organization (GO:0034724)3.19328616
115negative regulation of DNA recombination (GO:0045910)3.12345924
116DNA replication checkpoint (GO:0000076)3.09423380
117pre-miRNA processing (GO:0031054)3.09086532
118ribosome assembly (GO:0042255)3.07534313
119non-recombinational repair (GO:0000726)3.05412196
120double-strand break repair via nonhomologous end joining (GO:0006303)3.05412196
121proteasome assembly (GO:0043248)3.04547868
122metaphase plate congression (GO:0051310)3.04150552
123DNA damage response, detection of DNA damage (GO:0042769)3.03908942
124spindle checkpoint (GO:0031577)2.98405339
125water-soluble vitamin biosynthetic process (GO:0042364)2.98172523
126mitotic spindle checkpoint (GO:0071174)2.96047142
127glycine metabolic process (GO:0006544)2.95692713
128negative regulation of sister chromatid segregation (GO:0033046)2.94276943
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94276943
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94276943
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94276943
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.94276943
133establishment of viral latency (GO:0019043)2.92445042
134serine family amino acid metabolic process (GO:0009069)2.91674566
135DNA ligation (GO:0006266)2.90956455
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.89418953
137negative regulation of chromosome segregation (GO:0051985)2.86319905
138isoprenoid biosynthetic process (GO:0008299)2.85119583
139DNA replication-dependent nucleosome organization (GO:0034723)2.85023496
140DNA replication-dependent nucleosome assembly (GO:0006335)2.85023496
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84776355
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.84776355
143IMP metabolic process (GO:0046040)2.83603082
144regulation of helicase activity (GO:0051095)2.83257819
145regulation of mitotic spindle checkpoint (GO:1903504)2.79197220
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79197220
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77986789
148nucleobase biosynthetic process (GO:0046112)2.77395110
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76749810
150branched-chain amino acid catabolic process (GO:0009083)2.75493913
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74898072
152aspartate family amino acid catabolic process (GO:0009068)2.74701918
153protein-lipid complex assembly (GO:0065005)2.74384041
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69355407
155cullin deneddylation (GO:0010388)2.68865479
156regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64832275
157regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64832275
158DNA strand renaturation (GO:0000733)2.64751803
159mitotic spindle assembly checkpoint (GO:0007094)2.63964049
160tRNA aminoacylation for protein translation (GO:0006418)2.61707261
161nucleotide-sugar biosynthetic process (GO:0009226)2.60914820
162spindle assembly checkpoint (GO:0071173)2.58695587
163regulation of coenzyme metabolic process (GO:0051196)2.56084336
164regulation of cofactor metabolic process (GO:0051193)2.56084336
165anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55700978
166amino acid activation (GO:0043038)2.55260456
167tRNA aminoacylation (GO:0043039)2.55260456
168negative regulation of ligase activity (GO:0051352)2.50200570
169negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50200570
170DNA strand elongation involved in DNA replication (GO:0006271)2.49530180
171regulation of chromosome segregation (GO:0051983)2.49366860
172regulation of centriole replication (GO:0046599)2.48831620
173heme transport (GO:0015886)2.48033844
174negative regulation of mitosis (GO:0045839)2.47662529
175nuclear pore complex assembly (GO:0051292)2.45695138
176regulation of mitotic sister chromatid separation (GO:0010965)2.45609943
177regulation of mitotic sister chromatid segregation (GO:0033047)2.45609943
178regulation of sister chromatid segregation (GO:0033045)2.45609943
179DNA catabolic process, exonucleolytic (GO:0000738)2.45452049
180daunorubicin metabolic process (GO:0044597)2.44686303
181polyketide metabolic process (GO:0030638)2.44686303
182doxorubicin metabolic process (GO:0044598)2.44686303
183positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41125302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.51640257
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.76541685
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.70825280
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.70043098
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.56480188
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.41700598
7E2F7_22180533_ChIP-Seq_HELA_Human4.88092412
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.19656596
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96619202
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.93154423
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20008072
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05177331
13AR_21909140_ChIP-Seq_LNCAP_Human2.98850214
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.97223594
15CLOCK_20551151_ChIP-Seq_293T_Human2.82718931
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.74227085
17* SALL1_21062744_ChIP-ChIP_HESCs_Human2.53397888
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.48375958
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37111032
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.35766998
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32424386
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25324009
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22659823
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21434484
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09158011
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.08164717
27* ELK1_19687146_ChIP-ChIP_HELA_Human2.05800196
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97802716
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91712371
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90238849
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89972314
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87169156
33NANOG_16153702_ChIP-ChIP_HESCs_Human1.85721881
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83447315
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81887295
36ZNF274_21170338_ChIP-Seq_K562_Hela1.80000805
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.79921508
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79241925
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75999605
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74490332
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73589515
42* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71706202
43* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71706202
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67997738
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67420056
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63880359
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63603473
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62352169
49* FLI1_27457419_Chip-Seq_LIVER_Mouse1.55183508
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54112688
51* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51791580
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51558918
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51391241
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50797710
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50740179
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50740179
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50740179
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49712197
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.49026472
60* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47167827
61HTT_18923047_ChIP-ChIP_STHdh_Human1.43920250
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.42947607
63* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41180116
64EWS_26573619_Chip-Seq_HEK293_Human1.41148847
65IGF1R_20145208_ChIP-Seq_DFB_Human1.39344933
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38757404
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38240993
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.37920067
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35573473
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35535478
71* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35098048
72* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32903022
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32492143
74FUS_26573619_Chip-Seq_HEK293_Human1.31878501
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.30483349
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28163853
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27386613
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26769362
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26488470
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25593948
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24702542
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24475994
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23992487
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22680024
85FOXP3_21729870_ChIP-Seq_TREG_Human1.22137079
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20458798
87DCP1A_22483619_ChIP-Seq_HELA_Human1.20134236
88SOX2_20726797_ChIP-Seq_SW620_Human1.19560124
89* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18907691
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17787952
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16508820
92VDR_23849224_ChIP-Seq_CD4+_Human1.15290129
93GABP_19822575_ChIP-Seq_HepG2_Human1.14900402
94* GATA4_25053715_ChIP-Seq_YYC3_Human1.14622625
95* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13130007
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.12567666
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12389706
98MYC_18940864_ChIP-ChIP_HL60_Human1.12182102
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11257993
100* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10722914
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08375468
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07912725
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07362121
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07185113
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06755640
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.06621617
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.06285815
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05278110
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03300504
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02904327
111* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02468797
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01808380
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01645671
114TTF2_22483619_ChIP-Seq_HELA_Human0.99069314
115EOMES_21245162_ChIP-Seq_HESCs_Human0.98693395
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.98572695
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98495613
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95942833
119* CDX2_20551321_ChIP-Seq_CACO-2_Human0.95746028
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94908761
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.94208540
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93682038
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93475768
124GATA1_26923725_Chip-Seq_HPCs_Mouse0.91744258
125* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91627189
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88195985
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88131668
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87679890
129PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86987302
130IRF1_19129219_ChIP-ChIP_H3396_Human0.86601408
131EGR1_19032775_ChIP-ChIP_M12_Human0.84487396
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83176366
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82547605
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82484509
135CJUN_26792858_Chip-Seq_BT549_Human0.81079057
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79934719
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79660898
138VDR_24787735_ChIP-Seq_THP-1_Human0.78902353
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78655260
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78051603
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.77381103
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76483074
143BCAT_22108803_ChIP-Seq_LS180_Human0.74717874
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74242904
145ER_23166858_ChIP-Seq_MCF-7_Human0.73046580
146TAF15_26573619_Chip-Seq_HEK293_Human0.72959299
147RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71768853
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.71435870
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71425417
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.69626145
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68549016
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65932698
153TP53_18474530_ChIP-ChIP_U2OS_Human0.61429152
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61175528
155EP300_21415370_ChIP-Seq_HL-1_Mouse0.60528877
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.60025932
157ESR1_15608294_ChIP-ChIP_MCF-7_Human0.59735605
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.58967190
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.57358668
160TP63_23658742_ChIP-Seq_EP156T_Human0.56446640
161BP1_19119308_ChIP-ChIP_Hs578T_Human0.56252588
162* SOX17_20123909_ChIP-Seq_XEN_Mouse0.55587811
163PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.54421675
164CDX2_22108803_ChIP-Seq_LS180_Human0.53781966
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.52548255
166* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51711288
167SOX2_18692474_ChIP-Seq_MEFs_Mouse0.51245204
168P300_19829295_ChIP-Seq_ESCs_Human0.50562290
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.50116240
170TCF3_18692474_ChIP-Seq_MEFs_Mouse0.49282122
171KAP1_22055183_ChIP-Seq_ESCs_Mouse0.49181751
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.48568795
173TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.48435787
174ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48081977
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.48012219
176RXR_22108803_ChIP-Seq_LS180_Human0.47399240
177CTBP2_25329375_ChIP-Seq_LNCAP_Human0.46859010
178FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46607925
179KLF5_20875108_ChIP-Seq_MESCs_Mouse0.46555254
180VDR_22108803_ChIP-Seq_LS180_Human0.45433373
181NR3C1_23031785_ChIP-Seq_PC12_Mouse0.45248885
182RAD21_21589869_ChIP-Seq_MESCs_Mouse0.45239316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.66428398
2MP0005360_urolithiasis6.97088417
3MP0005085_abnormal_gallbladder_physiolo5.29127201
4MP0005365_abnormal_bile_salt5.18926237
5MP0008875_abnormal_xenobiotic_pharmacok4.75092155
6MP0003195_calcinosis4.28257670
7MP0003890_abnormal_embryonic-extraembry3.98726550
8MP0003806_abnormal_nucleotide_metabolis3.92377962
9MP0003941_abnormal_skin_development3.68010655
10MP0010329_abnormal_lipoprotein_level3.30731291
11MP0003252_abnormal_bile_duct3.14032746
12MP0005332_abnormal_amino_acid2.88718298
13MP0009840_abnormal_foam_cell2.85821675
14MP0003693_abnormal_embryo_hatching2.83750473
15MP0004957_abnormal_blastocyst_morpholog2.79284772
16MP0010094_abnormal_chromosome_stability2.60490763
17MP0008058_abnormal_DNA_repair2.50174453
18MP0005083_abnormal_biliary_tract2.46891972
19MP0004019_abnormal_vitamin_homeostasis2.43047226
20MP0003122_maternal_imprinting2.31641669
21MP0001666_abnormal_nutrient_absorption2.25317364
22MP0003111_abnormal_nucleus_morphology2.24899118
23MP0003191_abnormal_cellular_cholesterol2.12499210
24MP0002118_abnormal_lipid_homeostasis2.06613673
25MP0008932_abnormal_embryonic_tissue2.05957674
26MP0008877_abnormal_DNA_methylation1.97357917
27MP0003567_abnormal_fetal_cardiomyocyte1.95952698
28MP0003121_genomic_imprinting1.90207569
29MP0001293_anophthalmia1.87417615
30MP0002138_abnormal_hepatobiliary_system1.83581467
31MP0003186_abnormal_redox_activity1.83264063
32MP0009672_abnormal_birth_weight1.81177166
33MP0003119_abnormal_digestive_system1.77706524
34MP0000609_abnormal_liver_physiology1.76944657
35MP0001529_abnormal_vocalization1.75091077
36MP0003136_yellow_coat_color1.72079899
37MP0002938_white_spotting1.71852599
38MP0003077_abnormal_cell_cycle1.71458422
39MP0003690_abnormal_glial_cell1.66871351
40MP0008057_abnormal_DNA_replication1.63570094
41MP0003011_delayed_dark_adaptation1.61667834
42MP0005584_abnormal_enzyme/coenzyme_acti1.60689128
43MP0003937_abnormal_limbs/digits/tail_de1.60329372
44MP0008007_abnormal_cellular_replicative1.59201939
45MP0005319_abnormal_enzyme/_coenzyme1.58201141
46MP0001730_embryonic_growth_arrest1.55011727
47MP0004133_heterotaxia1.53023715
48MP0008438_abnormal_cutaneous_collagen1.49633844
49MP0003123_paternal_imprinting1.49427193
50MP0006054_spinal_hemorrhage1.48915940
51MP0005394_taste/olfaction_phenotype1.48676571
52MP0005499_abnormal_olfactory_system1.48676571
53MP0009643_abnormal_urine_homeostasis1.47303796
54MP0010030_abnormal_orbit_morphology1.46361116
55MP0006292_abnormal_olfactory_placode1.42630694
56MP0002084_abnormal_developmental_patter1.36221880
57MP0002102_abnormal_ear_morphology1.35529481
58MP0003868_abnormal_feces_composition1.32493213
59MP0008789_abnormal_olfactory_epithelium1.32216281
60MP0002233_abnormal_nose_morphology1.30649679
61MP0000604_amyloidosis1.29870951
62MP0009053_abnormal_anal_canal1.29296140
63MP0003705_abnormal_hypodermis_morpholog1.26782724
64MP0005380_embryogenesis_phenotype1.26174746
65MP0001672_abnormal_embryogenesis/_devel1.26174746
66MP0002697_abnormal_eye_size1.26120546
67MP0005451_abnormal_body_composition1.25685128
68MP0005647_abnormal_sex_gland1.25383313
69MP0001286_abnormal_eye_development1.24359386
70MP0005408_hypopigmentation1.23073861
71MP0001984_abnormal_olfaction1.21754115
72MP0003315_abnormal_perineum_morphology1.20226439
73MP0009703_decreased_birth_body1.20130247
74MP0001697_abnormal_embryo_size1.16000834
75MP0001764_abnormal_homeostasis1.15948074
76MP0002085_abnormal_embryonic_tissue1.15650657
77MP0001661_extended_life_span1.11884587
78MP0002111_abnormal_tail_morphology1.07928311
79MP0009697_abnormal_copulation1.06221753
80MP0003984_embryonic_growth_retardation1.04469214
81MP0002088_abnormal_embryonic_growth/wei1.04004870
82MP0005636_abnormal_mineral_homeostasis1.03488854
83MP0000516_abnormal_urinary_system1.03173934
84MP0005367_renal/urinary_system_phenotyp1.03173934
85MP0004130_abnormal_muscle_cell1.02152470
86MP0009764_decreased_sensitivity_to1.01918136
87MP0004272_abnormal_basement_membrane1.00534083
88MP0002876_abnormal_thyroid_physiology1.00145079
89MP0000598_abnormal_liver_morphology0.98453006
90MP0005248_abnormal_Harderian_gland0.97070512
91MP0000566_synostosis0.96596383
92MP0003329_amyloid_beta_deposits0.94625527
93MP0001756_abnormal_urination0.93989742
94MP0004264_abnormal_extraembryonic_tissu0.93901736
95MP0010352_gastrointestinal_tract_polyps0.93841038
96MP0005670_abnormal_white_adipose0.92923423
97MP0001188_hyperpigmentation0.92902033
98MP0002254_reproductive_system_inflammat0.92332296
99MP0000538_abnormal_urinary_bladder0.92297999
100MP0006072_abnormal_retinal_apoptosis0.91642493
101MP0002751_abnormal_autonomic_nervous0.91227170
102MP0002295_abnormal_pulmonary_circulatio0.91042747
103MP0002080_prenatal_lethality0.90565676
104MP0004197_abnormal_fetal_growth/weight/0.90423296
105MP0005084_abnormal_gallbladder_morpholo0.90293114
106MP0001485_abnormal_pinna_reflex0.89859849
107MP0009384_cardiac_valve_regurgitation0.88815154
108MP0005058_abnormal_lysosome_morphology0.88255250
109MP0005334_abnormal_fat_pad0.87278118
110MP0003656_abnormal_erythrocyte_physiolo0.86357109
111MP0003786_premature_aging0.86309635
112MP0002168_other_aberrant_phenotype0.84555737
113MP0004782_abnormal_surfactant_physiolog0.84522704
114MP0001299_abnormal_eye_distance/0.84229070
115MP0000350_abnormal_cell_proliferation0.83299856
116MP0002092_abnormal_eye_morphology0.80510329
117MP0002086_abnormal_extraembryonic_tissu0.80284847
118MP0009763_increased_sensitivity_to0.79912120
119MP0005666_abnormal_adipose_tissue0.79308883
120MP0003755_abnormal_palate_morphology0.79177465
121MP0002736_abnormal_nociception_after0.78152944
122MP0005391_vision/eye_phenotype0.76729453
123MP0009642_abnormal_blood_homeostasis0.76719852
124MP0004883_abnormal_blood_vessel0.76345912
125MP0005395_other_phenotype0.74991361
126MP0005535_abnormal_body_temperature0.73412573
127MP0005376_homeostasis/metabolism_phenot0.72995326
128MP0005253_abnormal_eye_physiology0.72828031
129MP0001915_intracranial_hemorrhage0.72775756
130MP0009765_abnormal_xenobiotic_induced0.71554371
131MP0001929_abnormal_gametogenesis0.71510369
132MP0002971_abnormal_brown_adipose0.71452662
133MP0005551_abnormal_eye_electrophysiolog0.71384842
134MP0010307_abnormal_tumor_latency0.70926947
135MP0000920_abnormal_myelination0.70587940
136MP0000639_abnormal_adrenal_gland0.70101237
137MP0003861_abnormal_nervous_system0.70063381
138MP0002136_abnormal_kidney_physiology0.69082010
139MP0008469_abnormal_protein_level0.67216776
140MP0005164_abnormal_response_to0.66021749
141MP0004043_abnormal_pH_regulation0.63402426
142MP0010368_abnormal_lymphatic_system0.59925057
143MP0002078_abnormal_glucose_homeostasis0.59025236
144MP0006035_abnormal_mitochondrial_morpho0.56055354
145MP0005197_abnormal_uvea_morphology0.56001353
146MP0004185_abnormal_adipocyte_glucose0.55925837
147MP0005220_abnormal_exocrine_pancreas0.55909594
148MP0003724_increased_susceptibility_to0.51793863
149MP0000647_abnormal_sebaceous_gland0.51705538
150MP0000230_abnormal_systemic_arterial0.51188156
151MP0005448_abnormal_energy_balance0.49966411
152MP0005266_abnormal_metabolism0.49708776
153MP0002090_abnormal_vision0.49581760
154MP0001177_atelectasis0.48128976
155MP0002282_abnormal_trachea_morphology0.47125326
156MP0006036_abnormal_mitochondrial_physio0.44473835
157MP0003953_abnormal_hormone_level0.43562397
158MP0005275_abnormal_skin_tensile0.42921900
159MP0002796_impaired_skin_barrier0.42173309
160MP0001881_abnormal_mammary_gland0.40486933
161MP0009115_abnormal_fat_cell0.40405642
162MP0001542_abnormal_bone_strength0.39289102
163MP0003718_maternal_effect0.39081673
164MP0003959_abnormal_lean_body0.39011825
165MP0001324_abnormal_eye_pigmentation0.35283027
166MP0000462_abnormal_digestive_system0.35264160
167MP0000537_abnormal_urethra_morphology0.35258424
168MP0000778_abnormal_nervous_system0.34444371
169MP0003436_decreased_susceptibility_to0.33557183
170MP0003075_altered_response_to0.32505042
171MP0002135_abnormal_kidney_morphology0.32417943
172MP0002896_abnormal_bone_mineralization0.32363639

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.02322087
2Xanthomatosis (HP:0000991)5.98075523
3Deep venous thrombosis (HP:0002625)5.80112958
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.75464659
5Hypobetalipoproteinemia (HP:0003563)5.39363540
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.13331687
7Epidermoid cyst (HP:0200040)5.09396738
8Prolonged partial thromboplastin time (HP:0003645)5.00952904
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.59190161
10Complement deficiency (HP:0004431)4.57575838
11Hyperlipoproteinemia (HP:0010980)4.48155618
12Hyperglycinuria (HP:0003108)4.41607034
13Abnormality of serine family amino acid metabolism (HP:0010894)4.32988427
14Abnormality of glycine metabolism (HP:0010895)4.32988427
15Abnormality of the labia minora (HP:0012880)4.21855796
16Hyperammonemia (HP:0001987)4.14656474
17Hypolipoproteinemia (HP:0010981)4.01994469
18Hyperglycinemia (HP:0002154)3.94695647
19Ketosis (HP:0001946)3.86664367
20Abnormality of fatty-acid metabolism (HP:0004359)3.81487144
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.80583183
22Fat malabsorption (HP:0002630)3.72095165
23Joint hemorrhage (HP:0005261)3.69544909
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.67880331
25Cortical dysplasia (HP:0002539)3.65215617
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.49625060
27Colon cancer (HP:0003003)3.49203702
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45998744
29Abnormality of the common coagulation pathway (HP:0010990)3.39273894
30Hypoglycemic coma (HP:0001325)3.39003584
31Hypoalphalipoproteinemia (HP:0003233)3.37619259
32Abnormality of complement system (HP:0005339)3.37394553
33Abnormal lung lobation (HP:0002101)3.21240430
34Abnormality of methionine metabolism (HP:0010901)3.17519658
35Hypercholesterolemia (HP:0003124)3.13550581
36Skin nodule (HP:0200036)3.10450250
37Ketoacidosis (HP:0001993)3.09913686
38Conjugated hyperbilirubinemia (HP:0002908)3.09784819
39Systemic lupus erythematosus (HP:0002725)3.05315942
40Ependymoma (HP:0002888)3.02824536
41Abnormality of glycolysis (HP:0004366)2.93291982
42Increased serum pyruvate (HP:0003542)2.93291982
43Steatorrhea (HP:0002570)2.92931327
44Abnormality of proline metabolism (HP:0010907)2.88698939
45Hydroxyprolinuria (HP:0003080)2.88698939
46Pancreatic islet-cell hyperplasia (HP:0004510)2.82736298
47Hepatoblastoma (HP:0002884)2.81257256
48Bifid tongue (HP:0010297)2.80330144
49Abnormality of purine metabolism (HP:0004352)2.74928016
50Hepatocellular carcinoma (HP:0001402)2.74503357
51Abnormality of the intrinsic pathway (HP:0010989)2.72839728
52Generalized aminoaciduria (HP:0002909)2.71352704
53Delayed CNS myelination (HP:0002188)2.70308330
54Abnormality of nucleobase metabolism (HP:0010932)2.69531166
55Proximal tubulopathy (HP:0000114)2.65421214
56Agnosia (HP:0010524)2.62219664
57Dicarboxylic aciduria (HP:0003215)2.62108345
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62108345
59Abnormality of serum amino acid levels (HP:0003112)2.62101394
60Myocardial infarction (HP:0001658)2.61977870
61Meckel diverticulum (HP:0002245)2.60806821
62Vascular calcification (HP:0004934)2.60286794
63Abnormality of pyrimidine metabolism (HP:0004353)2.58737467
64Lethargy (HP:0001254)2.58547160
65Embryonal renal neoplasm (HP:0011794)2.57022268
66Hyperbilirubinemia (HP:0002904)2.56917788
67Rhabdomyosarcoma (HP:0002859)2.55093656
68Nephroblastoma (Wilms tumor) (HP:0002667)2.54285915
69Medulloblastoma (HP:0002885)2.50770393
70Nausea (HP:0002018)2.50369002
71Hypophosphatemic rickets (HP:0004912)2.47122787
72Cerebral edema (HP:0002181)2.46678269
73Septo-optic dysplasia (HP:0100842)2.46210649
74Glomerulonephritis (HP:0000099)2.45848110
75Abnormality of the ileum (HP:0001549)2.45773820
76Abnormality of urine glucose concentration (HP:0011016)2.45693317
77Glycosuria (HP:0003076)2.45693317
78Metabolic acidosis (HP:0001942)2.43500259
79Recurrent gram-negative bacterial infections (HP:0005420)2.42922036
80Gout (HP:0001997)2.42136865
81Methylmalonic acidemia (HP:0002912)2.41914050
82Cardiovascular calcification (HP:0011915)2.40402138
83Hypoplastic pelvis (HP:0008839)2.40157971
84Abnormality of chromosome stability (HP:0003220)2.35973759
85Irritability (HP:0000737)2.34468675
86Vomiting (HP:0002013)2.31110026
87Hemorrhage of the eye (HP:0011885)2.30865089
88Intestinal atresia (HP:0011100)2.30225576
89Rickets (HP:0002748)2.25592915
90Supernumerary spleens (HP:0009799)2.25501887
91Enlarged kidneys (HP:0000105)2.23875440
92Gonadotropin excess (HP:0000837)2.22819579
93Myelomeningocele (HP:0002475)2.22812748
94Spastic diplegia (HP:0001264)2.22142758
95Glioma (HP:0009733)2.21997963
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18943136
97Abnormality of alanine metabolism (HP:0010916)2.17410790
98Hyperalaninemia (HP:0003348)2.17410790
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17410790
100Hypoplastic female external genitalia (HP:0012815)2.10381910
101Brushfield spots (HP:0001088)2.08964786
102Alkalosis (HP:0001948)2.08499233
103Chromsome breakage (HP:0040012)2.08199252
104Abnormality of the duodenum (HP:0002246)2.07204432
105Malnutrition (HP:0004395)2.06754967
106Astrocytoma (HP:0009592)2.05168623
107Abnormality of the astrocytes (HP:0100707)2.05168623
108Aplasia/Hypoplasia of the uvula (HP:0010293)2.04642065
109Labial hypoplasia (HP:0000066)2.04310012
110Spontaneous abortion (HP:0005268)2.03397609
111Sensorimotor neuropathy (HP:0007141)2.02313383
112Mitral stenosis (HP:0001718)2.02238901
113Abnormal enzyme/coenzyme activity (HP:0012379)2.01315375
114Neurofibrillary tangles (HP:0002185)2.00445588
115Birth length less than 3rd percentile (HP:0003561)1.99695268
116Pancreatitis (HP:0001733)1.98606299
117Amyloidosis (HP:0011034)1.98228998
118Opisthotonus (HP:0002179)1.96964663
119Anal stenosis (HP:0002025)1.94351660
120Acute encephalopathy (HP:0006846)1.92842874
121Axonal loss (HP:0003447)1.92713015
122Abnormality of the preputium (HP:0100587)1.90818415
123Stenosis of the external auditory canal (HP:0000402)1.90605490
124Abnormal hair whorl (HP:0010721)1.90058776
125Methylmalonic aciduria (HP:0012120)1.89019748
126Epiphyseal stippling (HP:0010655)1.88617799
127Renal hypoplasia (HP:0000089)1.87539021
128Vaginal fistula (HP:0004320)1.87371973
129Hyperuricemia (HP:0002149)1.86948532
130Increased purine levels (HP:0004368)1.86948532
131Neonatal onset (HP:0003623)1.86767777
132Abnormality of the clitoris (HP:0000056)1.85106669
133Absent radius (HP:0003974)1.84847435
134Increased nuchal translucency (HP:0010880)1.84673575
135Small intestinal stenosis (HP:0012848)1.84499808
136Duodenal stenosis (HP:0100867)1.84499808
137Volvulus (HP:0002580)1.84126625
138Clitoromegaly (HP:0000057)1.83689885
139Hypochromic microcytic anemia (HP:0004840)1.82945163
140Acanthocytosis (HP:0001927)1.82085803
141Hypoglycemic seizures (HP:0002173)1.82026070
142Scrotal hypoplasia (HP:0000046)1.81758762
143Degeneration of anterior horn cells (HP:0002398)1.80196157
144Abnormality of the anterior horn cell (HP:0006802)1.80196157
145Hyperinsulinemic hypoglycemia (HP:0000825)1.79809151
146Abnormal gallbladder morphology (HP:0012437)1.79170978
147Nephritis (HP:0000123)1.78603073
148Elevated alkaline phosphatase (HP:0003155)1.78473899
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.78428261
150Megaloblastic anemia (HP:0001889)1.77100338
151Renal cortical cysts (HP:0000803)1.76594891
152Abnormality of alkaline phosphatase activity (HP:0004379)1.76026686
153Aplasia involving forearm bones (HP:0009822)1.75105041
154Absent forearm bone (HP:0003953)1.75105041
155Spastic paraparesis (HP:0002313)1.74120338
156Choanal stenosis (HP:0000452)1.73831011
157Abnormality of the vitamin B12 metabolism (HP:0004341)1.73760097
158* Abnormal cartilage morphology (HP:0002763)1.73283075
159Esophageal varix (HP:0002040)1.72567466
160Symptomatic seizures (HP:0011145)1.71771602
161Biliary tract neoplasm (HP:0100574)1.70743863
162Back pain (HP:0003418)1.70553716
163Bifid scrotum (HP:0000048)1.69163389
164Abnormal biliary tract physiology (HP:0012439)1.69096103
165Bile duct proliferation (HP:0001408)1.69096103
166Hemivertebrae (HP:0002937)1.68782828
167Abnormality of the labia (HP:0000058)1.67927788
168Neoplasm of the colon (HP:0100273)1.67038766
169Rectovaginal fistula (HP:0000143)1.66861809
170Rectal fistula (HP:0100590)1.66861809
171Anophthalmia (HP:0000528)1.65614349
172Decreased muscle mass (HP:0003199)1.65521611
173Postnatal microcephaly (HP:0005484)1.65162111
174Gastrointestinal carcinoma (HP:0002672)1.65084941
175Malignant gastrointestinal tract tumors (HP:0006749)1.65084941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.48874362
2TRIM283.52898423
3TSSK63.41171200
4TTK3.10076152
5BUB13.06367552
6MARK13.02719286
7EPHB12.93263866
8SIK12.81861056
9MKNK22.74242398
10NEK12.63112801
11STK392.61993517
12ACVR1B2.59491076
13SRPK12.48288701
14MST1R2.47797205
15PLK32.44581284
16MKNK12.41422914
17ERBB42.33381280
18FGFR42.30583534
19DYRK22.29783513
20PBK2.20095250
21CDC72.16769306
22BCR2.14461272
23EIF2AK32.06391464
24WNK42.05907327
25PLK42.05808572
26OXSR12.05291615
27ERN11.98285931
28LIMK11.98215043
29FRK1.97614809
30ZAK1.83826924
31WEE11.81268645
32BRSK21.80312250
33ERBB31.79602712
34EPHB21.77791311
35EIF2AK11.74601104
36ABL21.74219925
37INSRR1.68077885
38MET1.65562514
39CASK1.62420587
40FGFR21.60078985
41WNK31.56671032
42PKN11.48764776
43PIK3CG1.47319971
44TAF11.41100608
45PLK11.40279084
46LATS11.39750044
47NEK91.35174184
48IRAK21.31767181
49VRK21.31244112
50PKN21.28642095
51MAP3K141.26424167
52MAPK131.26391339
53SGK4941.22924838
54SGK2231.22924838
55CSNK1G31.22306573
56STK161.22005906
57GSK3A1.18970764
58CSNK1G11.13610569
59PAK31.11605730
60CSNK1A1L1.10881499
61PLK21.09741536
62VRK11.09259833
63PNCK1.07383787
64IRAK41.06661167
65TGFBR11.02122606
66NUAK10.99029121
67TNIK0.98098331
68PRKCZ0.97596678
69TESK10.97336812
70CAMK1D0.97107872
71MST40.95702727
72EPHA30.94886572
73PDK20.94602200
74PIK3CA0.91802233
75DYRK1B0.89196479
76ERBB20.88506600
77CSNK1G20.88308409
78BRSK10.84618824
79MAP4K20.82353797
80PTK60.81777458
81MAP3K40.81477583
82ATR0.76254294
83FLT30.75345079
84ALK0.74678126
85MAP2K10.74315444
86PAK40.72869907
87CDK60.70930678
88LMTK20.70844304
89ROCK10.70715953
90STK38L0.70174888
91TYRO30.68825936
92ATM0.68019348
93GRK10.67758333
94IRAK10.66487685
95STK30.64524703
96TAOK30.62949665
97BLK0.62630975
98PASK0.62227814
99PRKCE0.62031343
100NEK20.61936654
101YES10.61632260
102MYLK0.61432103
103MAPK40.61395793
104CHEK20.61374037
105CSNK1E0.61177666
106EIF2AK20.60469384
107DYRK30.58975131
108JAK20.58954378
109AURKB0.58310308
110TRIB30.58219309
111PRKACG0.57874605
112MAP3K20.57618272
113SIK30.57610083
114NLK0.56246105
115MAP2K40.55120845
116TYK20.53787073
117LATS20.53383226
118NTRK10.52770967
119PRKAA20.52388316
120MINK10.51645349
121PTK20.51426387
122IGF1R0.51117787
123BMPR1B0.50573282
124NME10.50497095
125PRKCG0.49805617
126PRKAA10.49282808
127STK40.48730657
128CHEK10.48621827
129TBK10.48553344
130CDK70.48316126
131EPHA40.48165528
132FER0.47776586
133MAPK110.46504391
134DAPK20.46045023
135DDR20.45177844
136MAPK120.44317169
137CSNK2A10.44211032
138SGK20.44091728
139PRKCQ0.43559394
140AKT30.43127888
141ICK0.42720951
142FGFR10.42259705
143PHKG10.41512455
144PHKG20.41512455
145CAMK1G0.40083482
146RIPK10.39301620
147CSNK2A20.38827179
148CAMK2G0.38586351
149CDK10.38546415
150PRKDC0.37870514
151PRKCD0.37072924
152UHMK10.36322218
153MAP2K70.36145041
154CSK0.35842980
155RET0.35833005
156MAP3K80.34438788
157RPS6KA40.30931594
158PRKD30.30298887
159CSNK1A10.29465289
160TIE10.28141237
161CDK180.27955170
162CDK20.27042258
163PINK10.26954069
164STK100.25834345
165PRKACB0.25599849
166MAP3K120.25065581

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52077192
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21298943
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.12424104
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.92181182
5Steroid biosynthesis_Homo sapiens_hsa001002.91434911
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76161350
7Butanoate metabolism_Homo sapiens_hsa006502.68046723
8Fatty acid degradation_Homo sapiens_hsa000712.67941362
9Nitrogen metabolism_Homo sapiens_hsa009102.57007286
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46044066
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45427910
12Tryptophan metabolism_Homo sapiens_hsa003802.43922886
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.39778057
14Fatty acid metabolism_Homo sapiens_hsa012122.32123932
15Propanoate metabolism_Homo sapiens_hsa006402.29750677
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29384420
17* Peroxisome_Homo sapiens_hsa041462.23572179
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15045361
19Complement and coagulation cascades_Homo sapiens_hsa046102.11728684
20Arginine biosynthesis_Homo sapiens_hsa002202.10990744
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06276294
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04642688
23Non-homologous end-joining_Homo sapiens_hsa034502.03623817
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03087192
25PPAR signaling pathway_Homo sapiens_hsa033202.01444771
26Mismatch repair_Homo sapiens_hsa034302.00457923
27Sulfur metabolism_Homo sapiens_hsa009202.00045747
28Fatty acid elongation_Homo sapiens_hsa000621.98347846
29Chemical carcinogenesis_Homo sapiens_hsa052041.96954950
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93106270
31Histidine metabolism_Homo sapiens_hsa003401.77471125
32Protein export_Homo sapiens_hsa030601.75532164
33beta-Alanine metabolism_Homo sapiens_hsa004101.68794676
34Retinol metabolism_Homo sapiens_hsa008301.61223307
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58609481
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54076740
37DNA replication_Homo sapiens_hsa030301.52463466
38Staphylococcus aureus infection_Homo sapiens_hsa051501.50595072
39Caffeine metabolism_Homo sapiens_hsa002321.48506690
40Pyruvate metabolism_Homo sapiens_hsa006201.47163134
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.45404429
42Phenylalanine metabolism_Homo sapiens_hsa003601.43168695
43Starch and sucrose metabolism_Homo sapiens_hsa005001.35026385
44Tyrosine metabolism_Homo sapiens_hsa003501.32344061
45RNA transport_Homo sapiens_hsa030131.27531258
46* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24407790
47Fat digestion and absorption_Homo sapiens_hsa049751.21350160
48Bile secretion_Homo sapiens_hsa049761.20114133
49Basal transcription factors_Homo sapiens_hsa030221.15649573
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15564829
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13667383
52Base excision repair_Homo sapiens_hsa034101.13378919
53Selenocompound metabolism_Homo sapiens_hsa004501.09238286
54Homologous recombination_Homo sapiens_hsa034401.09219064
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07641508
56RNA polymerase_Homo sapiens_hsa030201.07342153
57Cell cycle_Homo sapiens_hsa041101.07213010
58* Glutathione metabolism_Homo sapiens_hsa004801.06697265
59Fatty acid biosynthesis_Homo sapiens_hsa000611.06004521
60* Carbon metabolism_Homo sapiens_hsa012001.04464608
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00190288
62Fanconi anemia pathway_Homo sapiens_hsa034601.00177099
63RNA degradation_Homo sapiens_hsa030180.98438310
64Vitamin digestion and absorption_Homo sapiens_hsa049770.97261427
65Spliceosome_Homo sapiens_hsa030400.96410077
66Folate biosynthesis_Homo sapiens_hsa007900.90626470
67Arginine and proline metabolism_Homo sapiens_hsa003300.88608658
68Nucleotide excision repair_Homo sapiens_hsa034200.82671712
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.79576777
70ABC transporters_Homo sapiens_hsa020100.77905487
71Sulfur relay system_Homo sapiens_hsa041220.75526493
72Glycerolipid metabolism_Homo sapiens_hsa005610.70337402
73* Biosynthesis of amino acids_Homo sapiens_hsa012300.70241809
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64614926
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63372823
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.62624835
77Vitamin B6 metabolism_Homo sapiens_hsa007500.62157273
78Lysine degradation_Homo sapiens_hsa003100.60491992
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59387154
80mRNA surveillance pathway_Homo sapiens_hsa030150.57873928
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.54994036
82Ovarian steroidogenesis_Homo sapiens_hsa049130.53132260
83* Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51733519
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50979800
85Pyrimidine metabolism_Homo sapiens_hsa002400.50501022
86Pentose phosphate pathway_Homo sapiens_hsa000300.50288942
87* Metabolic pathways_Homo sapiens_hsa011000.49515509
88Purine metabolism_Homo sapiens_hsa002300.48046020
89Oocyte meiosis_Homo sapiens_hsa041140.44994938
90TGF-beta signaling pathway_Homo sapiens_hsa043500.42498358
91Huntingtons disease_Homo sapiens_hsa050160.41975320
92N-Glycan biosynthesis_Homo sapiens_hsa005100.41723464
93Basal cell carcinoma_Homo sapiens_hsa052170.36770116
94Hippo signaling pathway_Homo sapiens_hsa043900.36305941
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35687789
96Prion diseases_Homo sapiens_hsa050200.34898640
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29762760
98Tight junction_Homo sapiens_hsa045300.29547163
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29343121
100Galactose metabolism_Homo sapiens_hsa000520.26902595
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24647314
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.24165849
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20741142
104Arachidonic acid metabolism_Homo sapiens_hsa005900.19209451
105Linoleic acid metabolism_Homo sapiens_hsa005910.17019085
106Phagosome_Homo sapiens_hsa041450.15305238
107One carbon pool by folate_Homo sapiens_hsa006700.14948900
108Mineral absorption_Homo sapiens_hsa049780.14871030
109Lysosome_Homo sapiens_hsa041420.14433410
110Ether lipid metabolism_Homo sapiens_hsa005650.14016848
111Fructose and mannose metabolism_Homo sapiens_hsa000510.13934441
112Insulin resistance_Homo sapiens_hsa049310.13086843
113Renin-angiotensin system_Homo sapiens_hsa046140.09912654
114AMPK signaling pathway_Homo sapiens_hsa041520.08718833
115Oxidative phosphorylation_Homo sapiens_hsa001900.05233618
116Legionellosis_Homo sapiens_hsa05134-0.1489124
117Collecting duct acid secretion_Homo sapiens_hsa04966-0.1309953
118Sphingolipid metabolism_Homo sapiens_hsa00600-0.1296019
119Proteasome_Homo sapiens_hsa03050-0.1177370
120Parkinsons disease_Homo sapiens_hsa05012-0.1174575
121Protein digestion and absorption_Homo sapiens_hsa04974-0.1121370
122Alzheimers disease_Homo sapiens_hsa05010-0.1119030
123Amoebiasis_Homo sapiens_hsa05146-0.1085025
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0952444
125Pertussis_Homo sapiens_hsa05133-0.0885334
126Axon guidance_Homo sapiens_hsa04360-0.0591442
127Hepatitis C_Homo sapiens_hsa05160-0.0512986
128Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0510707
129Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0133957

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