ID4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal stem cell maintenance (GO:0097150)5.25067701
2heart valve formation (GO:0003188)4.88980438
3cilium movement (GO:0003341)4.34056446
4layer formation in cerebral cortex (GO:0021819)4.21470881
5neuron fate determination (GO:0048664)4.19990067
6neuron cell-cell adhesion (GO:0007158)4.17927962
7negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.11667658
8vocalization behavior (GO:0071625)4.08571599
9axoneme assembly (GO:0035082)3.95315862
10tongue development (GO:0043586)3.93011466
11dermatan sulfate biosynthetic process (GO:0030208)3.92905632
12dendritic spine morphogenesis (GO:0060997)3.92486259
13otic vesicle formation (GO:0030916)3.91064177
14pattern specification involved in kidney development (GO:0061004)3.81854260
15* central nervous system myelination (GO:0022010)3.81051690
16* axon ensheathment in central nervous system (GO:0032291)3.81051690
17locomotory exploration behavior (GO:0035641)3.80003761
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.78427223
19regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.76499072
20* negative regulation of oligodendrocyte differentiation (GO:0048715)3.68341529
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63096819
22auditory behavior (GO:0031223)3.61644502
23gamma-aminobutyric acid transport (GO:0015812)3.61289664
24response to auditory stimulus (GO:0010996)3.58622676
25cellular potassium ion homeostasis (GO:0030007)3.58110480
26regulation of synapse structural plasticity (GO:0051823)3.56672690
27cell-cell signaling involved in cell fate commitment (GO:0045168)3.55381599
28dermatan sulfate metabolic process (GO:0030205)3.51780160
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51456918
30vascular smooth muscle contraction (GO:0014829)3.50262544
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49522287
32urinary tract smooth muscle contraction (GO:0014848)3.48018592
33cochlea development (GO:0090102)3.47743624
34prepulse inhibition (GO:0060134)3.42841087
35neurotransmitter-gated ion channel clustering (GO:0072578)3.42449409
36negative regulation of sodium ion transport (GO:0010766)3.41661199
37regulation of mesenchymal cell apoptotic process (GO:2001053)3.41648574
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.40540982
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40456529
40olfactory bulb development (GO:0021772)3.39896082
41neuron recognition (GO:0008038)3.38224783
42cGMP-mediated signaling (GO:0019934)3.37957468
43Notch signaling involved in heart development (GO:0061314)3.35600960
44transmission of nerve impulse (GO:0019226)3.34063895
45regulation of glutamate receptor signaling pathway (GO:1900449)3.31752919
46nephron tubule formation (GO:0072079)3.31646824
47epithelial cilium movement (GO:0003351)3.30868855
48protein localization to synapse (GO:0035418)3.30520111
49radial glial cell differentiation (GO:0060019)3.30233794
50axonal fasciculation (GO:0007413)3.28514516
51synaptic vesicle maturation (GO:0016188)3.26954214
52proline transport (GO:0015824)3.25470391
53axonemal dynein complex assembly (GO:0070286)3.23915314
54sodium ion export (GO:0071436)3.23295710
55synaptic vesicle exocytosis (GO:0016079)3.22736494
56pyrimidine nucleobase catabolic process (GO:0006208)3.19358400
57glutamate receptor signaling pathway (GO:0007215)3.18025054
58astrocyte differentiation (GO:0048708)3.17936364
59developmental induction (GO:0031128)3.16662241
60positive regulation of vascular permeability (GO:0043117)3.16428042
61appendage development (GO:0048736)3.16024285
62limb development (GO:0060173)3.16024285
63dendrite morphogenesis (GO:0048813)3.15268326
64glial cell proliferation (GO:0014009)3.14406151
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11904098
66lateral sprouting from an epithelium (GO:0060601)3.11688092
67regulation of neuronal synaptic plasticity (GO:0048168)3.11024286
68positive regulation of neuroblast proliferation (GO:0002052)3.09984346
69alanine transport (GO:0032328)3.02394713
70exploration behavior (GO:0035640)3.02058040
71artery smooth muscle contraction (GO:0014824)3.01753128
72apical protein localization (GO:0045176)3.01433362
73endocardial cushion morphogenesis (GO:0003203)3.01206408
74synaptic transmission, glutamatergic (GO:0035249)2.99305735
75establishment of planar polarity (GO:0001736)2.98610806
76establishment of tissue polarity (GO:0007164)2.98610806
77positive regulation of synapse assembly (GO:0051965)2.98236516
78histone H2B ubiquitination (GO:0033523)2.98184115
79ventricular trabecula myocardium morphogenesis (GO:0003222)2.98086643
80regulation of respiratory system process (GO:0044065)2.97766601
81cilium or flagellum-dependent cell motility (GO:0001539)2.97210172
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97203408
83glutamate secretion (GO:0014047)2.97005288
84neurotransmitter secretion (GO:0007269)2.96910863
85regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.96597521
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.96503246
87postsynaptic membrane organization (GO:0001941)2.96243169
88response to histamine (GO:0034776)2.95992102
89ventricular system development (GO:0021591)2.95735298
90positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95199299
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93681934
92neuronal action potential propagation (GO:0019227)2.93088916
93cranial nerve development (GO:0021545)2.92721011
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91616251
95retinal ganglion cell axon guidance (GO:0031290)2.90704079
96cell communication by electrical coupling (GO:0010644)2.89787445
97regulation of dendritic spine morphogenesis (GO:0061001)2.89610874
98cell differentiation involved in metanephros development (GO:0072202)2.89414865
99regulation of non-canonical Wnt signaling pathway (GO:2000050)2.88991527
100neurotransmitter uptake (GO:0001504)2.88039718
101mesenchyme morphogenesis (GO:0072132)2.87668450
102cellular sodium ion homeostasis (GO:0006883)2.85980965
103L-amino acid import (GO:0043092)2.85979366
104neuronal ion channel clustering (GO:0045161)2.85752637
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84645599
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.83555895
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83468006
108cell migration in hindbrain (GO:0021535)2.83462938
109presynaptic membrane assembly (GO:0097105)2.83353094
110cellular response to cholesterol (GO:0071397)2.82827252
111behavioral response to cocaine (GO:0048148)2.82137862
112response to pheromone (GO:0019236)2.81768349
113nephron epithelium morphogenesis (GO:0072088)2.80610748
114nephron tubule morphogenesis (GO:0072078)2.80610748
115positive regulation of dendritic spine development (GO:0060999)2.79317953
116photoreceptor cell differentiation (GO:0046530)2.78800970
117eye photoreceptor cell differentiation (GO:0001754)2.78800970
118neuron-neuron synaptic transmission (GO:0007270)2.77764614
119* negative regulation of glial cell differentiation (GO:0045686)2.76301421
120mechanosensory behavior (GO:0007638)2.76113973
121limb bud formation (GO:0060174)2.75593462
122nonmotile primary cilium assembly (GO:0035058)2.75565338
123outer ear morphogenesis (GO:0042473)2.74129823
124enteric nervous system development (GO:0048484)2.73704693
125cerebral cortex radially oriented cell migration (GO:0021799)2.72835804
126long-term synaptic potentiation (GO:0060291)2.71398558
127innervation (GO:0060384)2.71243707
128regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.70353022
129potassium ion homeostasis (GO:0055075)2.70011982
130central nervous system projection neuron axonogenesis (GO:0021952)2.68851167
131negative regulation of axon guidance (GO:1902668)2.67993159
132mesenchymal cell development (GO:0014031)2.67860802
133synapse assembly (GO:0007416)2.67154204
134positive regulation of male gonad development (GO:2000020)2.66500799
135heart trabecula morphogenesis (GO:0061384)2.65908459
136cell proliferation in forebrain (GO:0021846)2.65009220
137somite development (GO:0061053)2.64912604
138female mating behavior (GO:0060180)2.64884113
139neurotransmitter transport (GO:0006836)2.64685124
140regulation of penile erection (GO:0060405)2.64512630
141regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.63840448
142long-term memory (GO:0007616)2.63733617
143presynaptic membrane organization (GO:0097090)2.63531795
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63257380
145regulation of respiratory gaseous exchange (GO:0043576)2.63213492
146* regulation of oligodendrocyte differentiation (GO:0048713)2.62420831
147amino acid import (GO:0043090)2.61838025
148* negative regulation of astrocyte differentiation (GO:0048712)2.61721880
149forebrain neuron differentiation (GO:0021879)2.60728773
150regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60359372
151oligodendrocyte differentiation (GO:0048709)2.59999679
152establishment of nucleus localization (GO:0040023)2.59961195
153regulation of cilium movement (GO:0003352)2.59797327
154asymmetric protein localization (GO:0008105)2.58984143
155mating behavior (GO:0007617)2.58860227
156regulation of synaptic vesicle exocytosis (GO:2000300)2.58560254
157membrane repolarization (GO:0086009)2.57475821
158axon extension involved in axon guidance (GO:0048846)2.57456805
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.57456805
160tonic smooth muscle contraction (GO:0014820)2.57188998
161positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56868882
162planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55728753
163synapse organization (GO:0050808)2.55427874
164smoothened signaling pathway (GO:0007224)2.54302186
165stem cell development (GO:0048864)2.53769346
166regulation of female receptivity (GO:0045924)2.51905885
167cerebellar granule cell differentiation (GO:0021707)2.51143968
168neuromuscular process controlling balance (GO:0050885)2.51069290
169regulation of dendritic spine development (GO:0060998)2.50358295
170positive regulation of dendritic spine morphogenesis (GO:0061003)2.48586390
171regulation of membrane repolarization (GO:0060306)2.48275575
172positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47844515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67637237
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10176414
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93665776
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87276044
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.87137982
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82226447
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82187330
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82187330
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73990520
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.72188977
11GBX2_23144817_ChIP-Seq_PC3_Human2.67901722
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59636556
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56180445
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.38671100
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34791250
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.34623315
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33259209
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25268502
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.19842611
20AR_21572438_ChIP-Seq_LNCaP_Human2.12846772
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.00544612
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92896271
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89794240
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89095300
25DROSHA_22980978_ChIP-Seq_HELA_Human1.87737132
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84371720
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82070687
28TAF15_26573619_Chip-Seq_HEK293_Human1.79903553
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77343176
30* RING1B_27294783_Chip-Seq_ESCs_Mouse1.74427435
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70793548
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69740031
33* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67674689
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.63815695
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.59340249
36* RING1B_27294783_Chip-Seq_NPCs_Mouse1.54788572
37RNF2_27304074_Chip-Seq_NSC_Mouse1.52158379
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.50897166
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47429450
40* REST_18959480_ChIP-ChIP_MESCs_Mouse1.45674036
41* EWS_26573619_Chip-Seq_HEK293_Human1.44750230
42IGF1R_20145208_ChIP-Seq_DFB_Human1.44534920
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42664978
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40307117
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.39760226
46* P300_19829295_ChIP-Seq_ESCs_Human1.39064787
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38498176
48SMAD4_21799915_ChIP-Seq_A2780_Human1.36191458
49* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34789929
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30118681
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28671455
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27197043
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26363154
54* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25926915
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.25629241
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25028733
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24756645
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24288450
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20750240
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20193060
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.19980874
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19464764
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19004966
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18891310
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18210860
66BCAT_22108803_ChIP-Seq_LS180_Human1.18120211
67TP53_18474530_ChIP-ChIP_U2OS_Human1.16942486
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13926500
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12666179
70* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12502086
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11765316
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10337681
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.09850459
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08479697
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08060956
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.07579558
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07454805
78AR_25329375_ChIP-Seq_VCAP_Human1.07122746
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06557006
80RXR_22108803_ChIP-Seq_LS180_Human1.06265850
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05370923
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05370923
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04832447
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04637637
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04290764
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.04064696
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03128336
88* AHR_22903824_ChIP-Seq_MCF-7_Human1.02675522
89AR_19668381_ChIP-Seq_PC3_Human1.02139779
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01703993
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.01547578
92RUNX2_22187159_ChIP-Seq_PCA_Human1.01189776
93* SOX9_26525672_Chip-Seq_HEART_Mouse1.01053681
94ER_23166858_ChIP-Seq_MCF-7_Human1.00743336
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00729801
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00216916
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00172192
98ZNF274_21170338_ChIP-Seq_K562_Hela0.99671076
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99216173
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98201762
101VDR_22108803_ChIP-Seq_LS180_Human0.98099959
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96737795
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95968729
104TP53_16413492_ChIP-PET_HCT116_Human0.95767086
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94351183
106* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92505728
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92485198
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92047941
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.90428489
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90148390
111* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89607341
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89519596
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88847567
114FUS_26573619_Chip-Seq_HEK293_Human0.88626408
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88521999
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88308564
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88019571
118* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87640617
119STAT3_23295773_ChIP-Seq_U87_Human0.87410129
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85910655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.78607265
2MP0005423_abnormal_somatic_nervous3.02647760
3MP0003880_abnormal_central_pattern2.98583079
4MP0003635_abnormal_synaptic_transmissio2.95984058
5MP0004270_analgesia2.78020306
6MP0000778_abnormal_nervous_system2.61406027
7MP0001984_abnormal_olfaction2.60612407
8MP0004858_abnormal_nervous_system2.59102549
9MP0001486_abnormal_startle_reflex2.56023700
10MP0005171_absent_coat_pigmentation2.51024382
11MP0009745_abnormal_behavioral_response2.49671399
12MP0002063_abnormal_learning/memory/cond2.44656713
13MP0003136_yellow_coat_color2.43425998
14MP0009046_muscle_twitch2.39918493
15MP0002064_seizures2.27922087
16MP0002572_abnormal_emotion/affect_behav2.22200744
17MP0004885_abnormal_endolymph2.13776016
18MP0005645_abnormal_hypothalamus_physiol2.06259689
19MP0002653_abnormal_ependyma_morphology2.03946821
20MP0002734_abnormal_mechanical_nocicepti2.00836532
21MP0005499_abnormal_olfactory_system1.98867637
22MP0005394_taste/olfaction_phenotype1.98867637
23MP0008789_abnormal_olfactory_epithelium1.94513606
24MP0002272_abnormal_nervous_system1.92735927
25MP0001485_abnormal_pinna_reflex1.92028094
26MP0005646_abnormal_pituitary_gland1.91694127
27MP0001968_abnormal_touch/_nociception1.91641517
28MP0002184_abnormal_innervation1.83944611
29MP0002557_abnormal_social/conspecific_i1.80959725
30MP0006276_abnormal_autonomic_nervous1.70020056
31MP0001502_abnormal_circadian_rhythm1.62813268
32MP0002822_catalepsy1.61991728
33MP0001440_abnormal_grooming_behavior1.60303829
34MP0003690_abnormal_glial_cell1.60140391
35MP0002733_abnormal_thermal_nociception1.59318180
36MP0002067_abnormal_sensory_capabilities1.57759718
37MP0000049_abnormal_middle_ear1.56254845
38MP0000569_abnormal_digit_pigmentation1.51643276
39MP0003878_abnormal_ear_physiology1.50017534
40MP0005377_hearing/vestibular/ear_phenot1.50017534
41* MP0002882_abnormal_neuron_morphology1.49699870
42MP0000383_abnormal_hair_follicle1.48495849
43MP0008569_lethality_at_weaning1.47999321
44MP0003329_amyloid_beta_deposits1.47393144
45MP0001501_abnormal_sleep_pattern1.47201663
46MP0000955_abnormal_spinal_cord1.43905447
47MP0002928_abnormal_bile_duct1.42440761
48MP0001970_abnormal_pain_threshold1.41843925
49MP0005248_abnormal_Harderian_gland1.40811558
50MP0005623_abnormal_meninges_morphology1.40081025
51MP0002249_abnormal_larynx_morphology1.39907818
52MP0002938_white_spotting1.37318414
53MP0001293_anophthalmia1.36161645
54MP0004742_abnormal_vestibular_system1.35862889
55MP0009053_abnormal_anal_canal1.35766668
56* MP0002152_abnormal_brain_morphology1.35030942
57MP0002736_abnormal_nociception_after1.34095322
58MP0000026_abnormal_inner_ear1.33732918
59* MP0003634_abnormal_glial_cell1.33012687
60MP0002697_abnormal_eye_size1.32148317
61MP0003122_maternal_imprinting1.28038990
62MP0001286_abnormal_eye_development1.27829279
63MP0006072_abnormal_retinal_apoptosis1.25670246
64MP0000631_abnormal_neuroendocrine_gland1.23934413
65MP0002752_abnormal_somatic_nervous1.23881733
66MP0005174_abnormal_tail_pigmentation1.22319276
67MP0004811_abnormal_neuron_physiology1.21871878
68MP0002909_abnormal_adrenal_gland1.21685148
69MP0003938_abnormal_ear_development1.19381414
70MP0001963_abnormal_hearing_physiology1.19195579
71MP0009250_abnormal_appendicular_skeleto1.17855091
72MP0002638_abnormal_pupillary_reflex1.14663265
73MP0004924_abnormal_behavior1.12447406
74MP0005386_behavior/neurological_phenoty1.12447406
75MP0002282_abnormal_trachea_morphology1.12414253
76MP0002066_abnormal_motor_capabilities/c1.12310226
77MP0009379_abnormal_foot_pigmentation1.11992978
78MP0005551_abnormal_eye_electrophysiolog1.11862526
79MP0002254_reproductive_system_inflammat1.11150285
80MP0002735_abnormal_chemical_nociception1.09244559
81MP0009780_abnormal_chondrocyte_physiolo1.08348555
82MP0005503_abnormal_tendon_morphology1.08246299
83MP0002233_abnormal_nose_morphology1.04200562
84* MP0003861_abnormal_nervous_system1.04001131
85MP0002277_abnormal_respiratory_mucosa1.02273032
86MP0000762_abnormal_tongue_morphology1.01717108
87MP0006292_abnormal_olfactory_placode1.01396219
88MP0003633_abnormal_nervous_system0.99249801
89MP0002751_abnormal_autonomic_nervous0.98847029
90MP0003632_abnormal_nervous_system0.95444851
91MP0003075_altered_response_to0.95302313
92MP0009384_cardiac_valve_regurgitation0.94385219
93MP0000751_myopathy0.93714075
94MP0001299_abnormal_eye_distance/0.93704000
95MP0002092_abnormal_eye_morphology0.93534369
96MP0000647_abnormal_sebaceous_gland0.93047223
97MP0003942_abnormal_urinary_system0.92979143
98MP0001905_abnormal_dopamine_level0.92695601
99MP0005391_vision/eye_phenotype0.91722744
100MP0004142_abnormal_muscle_tone0.91474609
101MP0002234_abnormal_pharynx_morphology0.91420281
102MP0010030_abnormal_orbit_morphology0.91256519
103MP0003879_abnormal_hair_cell0.90119207
104MP0001529_abnormal_vocalization0.87599912
105MP0000566_synostosis0.87565120
106MP0003119_abnormal_digestive_system0.86772884
107MP0000534_abnormal_ureter_morphology0.86403264
108MP0005187_abnormal_penis_morphology0.84857764
109MP0003385_abnormal_body_wall0.84778360
110MP0005084_abnormal_gallbladder_morpholo0.84036937
111MP0005195_abnormal_posterior_eye0.83916539
112MP0005253_abnormal_eye_physiology0.83793844
113MP0004133_heterotaxia0.83465556
114MP0000537_abnormal_urethra_morphology0.82749374
115MP0003137_abnormal_impulse_conducting0.82196747
116MP0002116_abnormal_craniofacial_bone0.80571516
117MP0002102_abnormal_ear_morphology0.80249197
118MP0003631_nervous_system_phenotype0.78986961
119MP0003755_abnormal_palate_morphology0.78939470
120MP0010678_abnormal_skin_adnexa0.78926647
121MP0002932_abnormal_joint_morphology0.77173210
122MP0002111_abnormal_tail_morphology0.75960207
123MP0005508_abnormal_skeleton_morphology0.75349515
124MP0001188_hyperpigmentation0.74916493
125MP0003283_abnormal_digestive_organ0.72213987
126MP0002069_abnormal_eating/drinking_beha0.72191127
127MP0000428_abnormal_craniofacial_morphol0.71818998
128MP0003937_abnormal_limbs/digits/tail_de0.71354381
129MP0000462_abnormal_digestive_system0.69542827
130MP0001177_atelectasis0.68009877

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.59388624
2Abnormal respiratory motile cilium physiology (HP:0012261)5.33459645
3Megalencephaly (HP:0001355)4.56194084
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.49517426
5Myokymia (HP:0002411)4.36093699
6Abnormal respiratory epithelium morphology (HP:0012253)4.34627545
7Abnormal respiratory motile cilium morphology (HP:0005938)4.34627545
8Rhinitis (HP:0012384)4.25799926
9Septo-optic dysplasia (HP:0100842)4.13042161
10Aplasia involving bones of the extremities (HP:0009825)3.76776929
11Aplasia involving bones of the upper limbs (HP:0009823)3.76776929
12Aplasia of the phalanges of the hand (HP:0009802)3.76776929
13Focal motor seizures (HP:0011153)3.62271354
14Esophageal atresia (HP:0002032)3.61064473
15Absent/shortened dynein arms (HP:0200106)3.37252008
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.37252008
17Hemiparesis (HP:0001269)3.18553674
18Rib fusion (HP:0000902)3.16010528
19Abnormality of binocular vision (HP:0011514)3.11911261
20Diplopia (HP:0000651)3.11911261
21Maternal diabetes (HP:0009800)3.08674567
22Focal seizures (HP:0007359)3.04954666
23Gastrointestinal atresia (HP:0002589)2.93938648
24Missing ribs (HP:0000921)2.90854345
25Bronchomalacia (HP:0002780)2.82594094
26Neurofibrillary tangles (HP:0002185)2.80356194
27Broad distal phalanx of finger (HP:0009836)2.77907862
28Progressive cerebellar ataxia (HP:0002073)2.77411293
29Anosmia (HP:0000458)2.71218901
30Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.70837604
31Vertebral hypoplasia (HP:0008417)2.70837604
32Large for gestational age (HP:0001520)2.67327456
33Oligodactyly (hands) (HP:0001180)2.61390386
34Humeroradial synostosis (HP:0003041)2.61009754
35Synostosis involving the elbow (HP:0003938)2.61009754
36Abnormality of the 4th metacarpal (HP:0010012)2.53638979
37Limb dystonia (HP:0002451)2.51161107
38Action tremor (HP:0002345)2.50800041
39Fibular hypoplasia (HP:0003038)2.46337988
40Partial duplication of thumb phalanx (HP:0009944)2.46332497
41Pancreatic cysts (HP:0001737)2.45369437
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.44165484
43Abnormality of the axillary hair (HP:0100134)2.43763549
44Abnormality of secondary sexual hair (HP:0009888)2.43763549
45Supranuclear gaze palsy (HP:0000605)2.43438165
46Epileptic encephalopathy (HP:0200134)2.39965430
47Morphological abnormality of the inner ear (HP:0011390)2.35313971
48Abnormality of the middle phalanges of the toes (HP:0010183)2.33586112
49Oligodactyly (HP:0012165)2.27261702
50Concave nail (HP:0001598)2.26743019
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26385425
52Morphological abnormality of the middle ear (HP:0008609)2.26190973
53Sclerocornea (HP:0000647)2.23180660
54Cerebral inclusion bodies (HP:0100314)2.21276293
55Hemiplegia (HP:0002301)2.21085315
56Neuroendocrine neoplasm (HP:0100634)2.20595055
57Optic nerve hypoplasia (HP:0000609)2.19473770
58Neonatal short-limb short stature (HP:0008921)2.19271799
59Visual hallucinations (HP:0002367)2.19246482
60Supernumerary ribs (HP:0005815)2.19144066
61Partial duplication of the phalanx of hand (HP:0009999)2.19039742
62Generalized tonic-clonic seizures (HP:0002069)2.18431905
63Gait imbalance (HP:0002141)2.17647717
64Tubulointerstitial nephritis (HP:0001970)2.15486860
65Postaxial foot polydactyly (HP:0001830)2.15179442
6611 pairs of ribs (HP:0000878)2.14135825
67Absent septum pellucidum (HP:0001331)2.10012476
68Pheochromocytoma (HP:0002666)2.07474494
69Anencephaly (HP:0002323)2.07436735
70Abnormality of the renal medulla (HP:0100957)2.06756205
71Atonic seizures (HP:0010819)2.05501726
72Postaxial hand polydactyly (HP:0001162)2.05039757
73Ankle clonus (HP:0011448)2.04630814
74Retinal dysplasia (HP:0007973)2.04494011
75Midline defect of the nose (HP:0004122)2.03148610
76Cystic liver disease (HP:0006706)2.02810650
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01554156
78Short 4th metacarpal (HP:0010044)2.01554156
79Aplasia/Hypoplasia of the fibula (HP:0006492)2.01464006
80Coronal craniosynostosis (HP:0004440)2.01075629
81Supernumerary bones of the axial skeleton (HP:0009144)2.00966770
82Renal hypoplasia (HP:0000089)1.96469398
83Hemivertebrae (HP:0002937)1.95590412
84Pancreatic fibrosis (HP:0100732)1.95072520
85Genital tract atresia (HP:0001827)1.94990033
86Preaxial foot polydactyly (HP:0001841)1.93052594
87Broad-based gait (HP:0002136)1.92649259
88Mixed hearing impairment (HP:0000410)1.91974979
89Potter facies (HP:0002009)1.90641518
90Facial shape deformation (HP:0011334)1.90641518
91Median cleft lip (HP:0000161)1.90198824
92Hypoplastic ilia (HP:0000946)1.89655460
93Torticollis (HP:0000473)1.89267746
94Supernumerary spleens (HP:0009799)1.89046490
95Anxiety (HP:0000739)1.88516176
96Absence seizures (HP:0002121)1.87819248
97Absent hair (HP:0002298)1.87448380
98Abnormality of the labia minora (HP:0012880)1.86897781
99Vaginal atresia (HP:0000148)1.86503878
100Amblyopia (HP:0000646)1.86369642
101Excessive salivation (HP:0003781)1.86217788
102Drooling (HP:0002307)1.86217788
103Split foot (HP:0001839)1.85541262
104Hepatoblastoma (HP:0002884)1.85236467
105Truncal ataxia (HP:0002078)1.84975257
106Dysdiadochokinesis (HP:0002075)1.83496268
107Vertebral clefting (HP:0008428)1.83424074
108True hermaphroditism (HP:0010459)1.83178286
109Abnormality of dentin (HP:0010299)1.82774429
110Febrile seizures (HP:0002373)1.82737540
111Congenital primary aphakia (HP:0007707)1.82420459
112Bicornuate uterus (HP:0000813)1.81905841
113Abnormal eating behavior (HP:0100738)1.81653186
114Intestinal atresia (HP:0011100)1.80590551
115Abnormality of the diencephalon (HP:0010662)1.80059991
116Chronic bronchitis (HP:0004469)1.78873411
117Bronchiectasis (HP:0002110)1.78483470
118Abnormality of the dental pulp (HP:0006479)1.78453282
119Short foot (HP:0001773)1.78101304
120Dialeptic seizures (HP:0011146)1.77893828
121Renal dysplasia (HP:0000110)1.77648875
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76867985
123Occipital encephalocele (HP:0002085)1.76629850
124Atelectasis (HP:0100750)1.76072736
125Abnormality of the dental root (HP:0006486)1.75810865
126Taurodontia (HP:0000679)1.75810865
127Abnormality of permanent molar morphology (HP:0011071)1.75810865
128Tubular atrophy (HP:0000092)1.75500993
129Bifid scrotum (HP:0000048)1.75225028
130Medial flaring of the eyebrow (HP:0010747)1.70611993
131Specific learning disability (HP:0001328)1.69236192
132Sex reversal (HP:0012245)1.67715926
133Abnormal sex determination (HP:0012244)1.67715926
134Abnormality of molar morphology (HP:0011070)1.67441810
135Abnormality of molar (HP:0011077)1.67441810
136Depression (HP:0000716)1.67317499
137Nephronophthisis (HP:0000090)1.66666271
138Cutaneous finger syndactyly (HP:0010554)1.66537665
139Focal dystonia (HP:0004373)1.66210424
140Hypoplastic left heart (HP:0004383)1.64821947
141Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.64043860
142Narrow nasal bridge (HP:0000446)1.63565499
143Molar tooth sign on MRI (HP:0002419)1.63523639
144Abnormality of midbrain morphology (HP:0002418)1.63523639
145Obstructive sleep apnea (HP:0002870)1.63356760
146Back pain (HP:0003418)1.62441491
147Anophthalmia (HP:0000528)1.61701591
148Fibular aplasia (HP:0002990)1.61673852
149Cutaneous syndactyly (HP:0012725)1.60283112
150Insomnia (HP:0100785)1.59765939
151Nephrogenic diabetes insipidus (HP:0009806)1.57469986
152Hyperventilation (HP:0002883)1.57147997
153Fragile nails (HP:0001808)1.56787188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.19324534
2MARK13.71151790
3NTRK23.45919878
4WEE13.43170575
5NTRK32.87732349
6PHKG12.74817854
7PHKG22.74817854
8PNCK2.54682657
9TNIK2.49557745
10LMTK22.39326262
11MAPK132.30575485
12TSSK62.29258116
13CASK2.28385751
14MAP3K42.28366580
15MINK12.10835867
16MAP3K91.94198734
17MAP2K71.91946210
18MAPK151.82436548
19DAPK21.78182548
20VRK11.76558684
21ERBB31.63112542
22EPHA31.60201164
23SIK21.55929868
24PRKD31.55387782
25PAK61.48305039
26EPHB21.43668918
27DDR21.40471389
28KSR11.36760677
29PAK31.33012635
30CDK51.29158666
31UHMK11.27297957
32MUSK1.23022156
33WNK11.14962018
34MAP3K21.09117369
35TYRO31.08242000
36MKNK11.07100733
37NTRK11.05804557
38DYRK21.04961520
39MAP2K41.02904016
40BRSK20.99372868
41PRKCG0.99337453
42SGK4940.98763067
43SGK2230.98763067
44BMPR1B0.98105152
45FGFR20.98089537
46DYRK1A0.97417497
47PINK10.96855846
48GRK50.95556236
49CAMKK10.95429549
50ROCK20.94765641
51ROCK10.93199953
52CAMK2A0.91570657
53CSNK1G20.84607283
54CDK140.84506068
55STK110.83743337
56CAMK2B0.83260791
57CAMK1G0.80448675
58FES0.78504087
59ARAF0.78049886
60CDK30.77950773
61PLK20.77758425
62ADRBK10.76802027
63PASK0.76694418
64CDK190.76091118
65CDK150.75647398
66KSR20.75038075
67CDK180.74015549
68MARK20.72436221
69SGK20.71842337
70NLK0.71329879
71OXSR10.70556587
72PRKCE0.69189567
73MAPK120.67207703
74LIMK10.67183897
75CDK11A0.66218525
76CDC42BPA0.66187659
77TGFBR10.65753595
78STK390.65572922
79WNK30.63144345
80FER0.62548554
81MKNK20.60308282
82CSNK1A1L0.60024973
83FGR0.59003215
84STK38L0.58860017
85SIK10.58303885
86CSNK1G30.57171862
87PAK20.56536194
88LATS10.55469192
89PRKCZ0.54272385
90DYRK30.54023741
91INSRR0.54012544
92FRK0.53769889
93PKN10.53593644
94SGK10.53585492
95CSNK1G10.52580646
96LATS20.52087018
97CAMK2G0.51824458
98STK380.51126241
99PRKCH0.50500622
100TRIB30.50462989
101CAMK2D0.50007156
102DAPK10.49617495
103MAP2K20.49406209
104PRKG10.49372916
105CAMKK20.49239921
106PRKD20.49070963
107WNK40.48520857
108FGFR10.47483980
109MAPK100.46805956
110FYN0.46634583
111DYRK1B0.45664742
112MAP3K70.45597390
113PLK30.44855190
114NEK90.44622945
115MAP3K60.44047431
116PRPF4B0.43924215
117BCR0.43710029
118PRKACA0.42559098
119GRK10.42469340
120AKT30.42366100
121RPS6KA30.42035685
122SGK30.41368694
123TAOK10.41186554
124TAF10.40701120
125RPS6KA20.40540385
126ERBB20.40357073
127MAPKAPK50.39726756
128IRAK10.38917499
129GSK3A0.37764578
130YES10.36192449
131PTK2B0.35146079
132STK240.34721397
133MOS0.34123999
134PIK3CA0.33986537
135ADRBK20.32038795
136BRSK10.31441221
137CAMK10.30091917
138PDGFRB0.26284844
139CSNK1D0.26099026
140RPS6KA50.25169122

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.38407217
2Nicotine addiction_Homo sapiens_hsa050333.30407407
3Olfactory transduction_Homo sapiens_hsa047403.02328532
4GABAergic synapse_Homo sapiens_hsa047272.58967139
5Glutamatergic synapse_Homo sapiens_hsa047242.42065303
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.31484541
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19504686
8Circadian entrainment_Homo sapiens_hsa047132.14568858
9Morphine addiction_Homo sapiens_hsa050322.11671533
10Amphetamine addiction_Homo sapiens_hsa050312.02074970
11Synaptic vesicle cycle_Homo sapiens_hsa047211.96095608
12Gastric acid secretion_Homo sapiens_hsa049711.94752171
13Steroid biosynthesis_Homo sapiens_hsa001001.93191058
14Cocaine addiction_Homo sapiens_hsa050301.91359292
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.89692540
16Taste transduction_Homo sapiens_hsa047421.86887073
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85946167
18Salivary secretion_Homo sapiens_hsa049701.83894089
19Long-term potentiation_Homo sapiens_hsa047201.82240621
20Dopaminergic synapse_Homo sapiens_hsa047281.81502293
21Insulin secretion_Homo sapiens_hsa049111.77809520
22Fatty acid biosynthesis_Homo sapiens_hsa000611.72794586
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58021670
24Axon guidance_Homo sapiens_hsa043601.56188288
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53851462
26Renin secretion_Homo sapiens_hsa049241.52931912
27Serotonergic synapse_Homo sapiens_hsa047261.50848286
28Cholinergic synapse_Homo sapiens_hsa047251.47730864
29Dorso-ventral axis formation_Homo sapiens_hsa043201.44034518
30* TGF-beta signaling pathway_Homo sapiens_hsa043501.44016345
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43438897
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39785931
33Gap junction_Homo sapiens_hsa045401.38542718
34Long-term depression_Homo sapiens_hsa047301.35839200
35Melanogenesis_Homo sapiens_hsa049161.34815449
36Calcium signaling pathway_Homo sapiens_hsa040201.32889288
37Cardiac muscle contraction_Homo sapiens_hsa042601.28513364
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26593451
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25855871
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19527765
41Oxytocin signaling pathway_Homo sapiens_hsa049211.18538291
42GnRH signaling pathway_Homo sapiens_hsa049121.18373016
43cAMP signaling pathway_Homo sapiens_hsa040241.16920794
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16264693
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15146114
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14043831
47Hedgehog signaling pathway_Homo sapiens_hsa043401.12617621
48Basal cell carcinoma_Homo sapiens_hsa052171.07086099
49Phototransduction_Homo sapiens_hsa047441.06789292
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04503966
51Estrogen signaling pathway_Homo sapiens_hsa049151.02462348
52Thyroid hormone synthesis_Homo sapiens_hsa049181.01761428
53ECM-receptor interaction_Homo sapiens_hsa045121.00397136
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97184734
55Protein export_Homo sapiens_hsa030600.96877448
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94439683
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94003653
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90808959
59beta-Alanine metabolism_Homo sapiens_hsa004100.85565328
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84860850
61Bile secretion_Homo sapiens_hsa049760.84531992
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84418880
63Wnt signaling pathway_Homo sapiens_hsa043100.83805364
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82543432
65Histidine metabolism_Homo sapiens_hsa003400.81932542
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79269096
67ErbB signaling pathway_Homo sapiens_hsa040120.77316697
68Alcoholism_Homo sapiens_hsa050340.76748913
69Hippo signaling pathway_Homo sapiens_hsa043900.76053531
70Protein digestion and absorption_Homo sapiens_hsa049740.75723619
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.73653252
72Colorectal cancer_Homo sapiens_hsa052100.72830787
73Pancreatic secretion_Homo sapiens_hsa049720.71713525
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71587509
75Butanoate metabolism_Homo sapiens_hsa006500.71426522
76Glioma_Homo sapiens_hsa052140.70161866
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.69940259
78Alzheimers disease_Homo sapiens_hsa050100.69118243
79Dilated cardiomyopathy_Homo sapiens_hsa054140.69014885
80Circadian rhythm_Homo sapiens_hsa047100.68288523
81Propanoate metabolism_Homo sapiens_hsa006400.68243589
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67953167
83Fanconi anemia pathway_Homo sapiens_hsa034600.67731231
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.65831421
85Rap1 signaling pathway_Homo sapiens_hsa040150.65816292
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65723576
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64185234
88Huntingtons disease_Homo sapiens_hsa050160.63445161
89Prion diseases_Homo sapiens_hsa050200.63188838
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62890269
91Pathways in cancer_Homo sapiens_hsa052000.62357366
92* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61126219
93Collecting duct acid secretion_Homo sapiens_hsa049660.60533265
94Mineral absorption_Homo sapiens_hsa049780.60469898
95Folate biosynthesis_Homo sapiens_hsa007900.60181068
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58820937
97Parkinsons disease_Homo sapiens_hsa050120.57981060
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57968127
99Oxidative phosphorylation_Homo sapiens_hsa001900.57913485
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57414151
101Ras signaling pathway_Homo sapiens_hsa040140.54336027
102Linoleic acid metabolism_Homo sapiens_hsa005910.54172595
103Choline metabolism in cancer_Homo sapiens_hsa052310.53355602
104Tight junction_Homo sapiens_hsa045300.52423684
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52379512
106Oocyte meiosis_Homo sapiens_hsa041140.52149754
107MAPK signaling pathway_Homo sapiens_hsa040100.52139599
108Renal cell carcinoma_Homo sapiens_hsa052110.49285496
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48670536
110Type II diabetes mellitus_Homo sapiens_hsa049300.48404103
111Sulfur relay system_Homo sapiens_hsa041220.47996526
112Glucagon signaling pathway_Homo sapiens_hsa049220.47103064
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.46129308
114Tryptophan metabolism_Homo sapiens_hsa003800.45949921
115Ether lipid metabolism_Homo sapiens_hsa005650.45616066
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45140079
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44119479
118Melanoma_Homo sapiens_hsa052180.37120868
119Notch signaling pathway_Homo sapiens_hsa043300.37030984
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36407956
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.35064857
122PPAR signaling pathway_Homo sapiens_hsa033200.32153519
123Ovarian steroidogenesis_Homo sapiens_hsa049130.31139468
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30823556
125Endometrial cancer_Homo sapiens_hsa052130.30645944
126Insulin signaling pathway_Homo sapiens_hsa049100.28124004
127Vibrio cholerae infection_Homo sapiens_hsa051100.26400789

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