ICE2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of appetite (GO:0032099)6.38036659
2negative regulation of response to food (GO:0032096)6.38036659
3behavioral response to nicotine (GO:0035095)6.26188841
4negative regulation of heart rate (GO:0010459)5.27217032
5snRNA transcription (GO:0009301)4.88211920
6signal peptide processing (GO:0006465)4.75944013
7interkinetic nuclear migration (GO:0022027)4.73037606
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.52712991
9protein polyglutamylation (GO:0018095)4.42591845
10regulation of pigment cell differentiation (GO:0050932)4.39495873
11cellular ketone body metabolic process (GO:0046950)4.19327965
12nucleotide transmembrane transport (GO:1901679)4.11453763
13translational termination (GO:0006415)4.08425504
14GMP metabolic process (GO:0046037)3.93922246
15G-protein coupled receptor internalization (GO:0002031)3.89949554
16epithelial cilium movement (GO:0003351)3.80451731
17viral transcription (GO:0019083)3.79289368
18positive regulation of developmental pigmentation (GO:0048087)3.76406506
19protein neddylation (GO:0045116)3.75882074
20ketone body metabolic process (GO:1902224)3.68810846
21regulation of response to food (GO:0032095)3.60575106
22regulation of appetite (GO:0032098)3.46176052
23regulation of cilium movement (GO:0003352)3.44689229
24tryptophan catabolic process (GO:0006569)3.37167771
25indole-containing compound catabolic process (GO:0042436)3.37167771
26indolalkylamine catabolic process (GO:0046218)3.37167771
27microtubule severing (GO:0051013)3.36848503
28positive regulation of DNA repair (GO:0045739)3.34671008
29sleep (GO:0030431)3.30531040
30translational elongation (GO:0006414)3.25558424
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19893505
32cotranslational protein targeting to membrane (GO:0006613)3.15477081
33negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.13359273
34kynurenine metabolic process (GO:0070189)3.12989465
35protein targeting to ER (GO:0045047)3.09668191
36indolalkylamine metabolic process (GO:0006586)3.08097115
37DNA deamination (GO:0045006)3.07891975
38cellular protein complex disassembly (GO:0043624)3.07095352
39cilium movement (GO:0003341)3.06482071
40cytokine biosynthetic process (GO:0042089)3.03157013
41regulation of translational termination (GO:0006449)3.01770466
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01602613
43negative regulation of neurotransmitter transport (GO:0051589)3.01121167
44regulation of memory T cell differentiation (GO:0043380)2.99434154
45cellular biogenic amine catabolic process (GO:0042402)2.97797262
46amine catabolic process (GO:0009310)2.97797262
47head development (GO:0060322)2.97227501
48mature B cell differentiation involved in immune response (GO:0002313)2.97057317
49ribosomal small subunit assembly (GO:0000028)2.94951028
50regulation of female gonad development (GO:2000194)2.93907010
51ribosomal large subunit biogenesis (GO:0042273)2.91755418
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91649266
53viral life cycle (GO:0019058)2.89537686
54poly(A)+ mRNA export from nucleus (GO:0016973)2.88848725
55protein localization to endoplasmic reticulum (GO:0070972)2.88297615
56protein prenylation (GO:0018342)2.87587047
57prenylation (GO:0097354)2.87587047
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86325741
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85406058
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85406058
61ATP synthesis coupled proton transport (GO:0015986)2.83617682
62energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83617682
63definitive hemopoiesis (GO:0060216)2.82471836
64aromatic amino acid family catabolic process (GO:0009074)2.80505756
65mature B cell differentiation (GO:0002335)2.79182586
66regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78331690
67parturition (GO:0007567)2.77922631
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.72568867
69regulation of MHC class II biosynthetic process (GO:0045346)2.71935378
70base-excision repair, AP site formation (GO:0006285)2.68902756
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68544851
72negative regulation of T-helper cell differentiation (GO:0045623)2.68544851
73regulation of RIG-I signaling pathway (GO:0039535)2.65993826
74anterograde synaptic vesicle transport (GO:0048490)2.65689177
75polyol catabolic process (GO:0046174)2.63864474
76axoneme assembly (GO:0035082)2.63548195
77negative regulation of neurotransmitter secretion (GO:0046929)2.61138345
78positive regulation of activated T cell proliferation (GO:0042104)2.60378121
79negative regulation of response to extracellular stimulus (GO:0032105)2.59812417
80negative regulation of response to nutrient levels (GO:0032108)2.59812417
81translational initiation (GO:0006413)2.59169138
82rhodopsin mediated signaling pathway (GO:0016056)2.58994547
83regulation of sensory perception of pain (GO:0051930)2.58347113
84regulation of sensory perception (GO:0051931)2.58347113
85protein complex disassembly (GO:0043241)2.56888854
86macromolecular complex disassembly (GO:0032984)2.56393002
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.54690784
88gland morphogenesis (GO:0022612)2.53878886
89organelle membrane fusion (GO:0090174)2.52891844
90reciprocal meiotic recombination (GO:0007131)2.52216929
91reciprocal DNA recombination (GO:0035825)2.52216929
92platelet dense granule organization (GO:0060155)2.52130970
93negative regulation by host of viral transcription (GO:0043922)2.51153274
94parental behavior (GO:0060746)2.50508796
95ribonucleoprotein complex disassembly (GO:0032988)2.49897336
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.49675884
97intra-S DNA damage checkpoint (GO:0031573)2.48260812
98regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.47984750
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.47169271
100negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.46105151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human2.80197516
2FUS_26573619_Chip-Seq_HEK293_Human2.80045192
3GBX2_23144817_ChIP-Seq_PC3_Human2.69744317
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68791348
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61350423
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60819175
7TAF15_26573619_Chip-Seq_HEK293_Human2.56568103
8EZH2_22144423_ChIP-Seq_EOC_Human2.50616837
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.39151881
10VDR_22108803_ChIP-Seq_LS180_Human2.31469477
11EWS_26573619_Chip-Seq_HEK293_Human2.24269382
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23988663
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.22802783
14ZNF274_21170338_ChIP-Seq_K562_Hela2.16688063
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15872570
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10098251
17ELK1_19687146_ChIP-ChIP_HELA_Human2.08058108
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06374083
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.97696748
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96111431
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88923461
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.85714577
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.84087277
24IRF1_19129219_ChIP-ChIP_H3396_Human1.81707231
25ER_23166858_ChIP-Seq_MCF-7_Human1.74721044
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.73662862
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.71773348
28P300_19829295_ChIP-Seq_ESCs_Human1.71438745
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69837843
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.60416780
31FOXA1_27270436_Chip-Seq_PROSTATE_Human1.60416780
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56403597
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55669424
34SOX2_19829295_ChIP-Seq_ESCs_Human1.55625532
35NANOG_19829295_ChIP-Seq_ESCs_Human1.55625532
36FOXA1_21572438_ChIP-Seq_LNCaP_Human1.54841680
37MYC_18940864_ChIP-ChIP_HL60_Human1.53765198
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52407806
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51460351
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49141782
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47626790
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46143852
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42286295
44VDR_23849224_ChIP-Seq_CD4+_Human1.40439935
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38667794
46TP53_22573176_ChIP-Seq_HFKS_Human1.36929288
47AR_25329375_ChIP-Seq_VCAP_Human1.34738901
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.34615684
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34279616
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33494038
51SMAD4_21799915_ChIP-Seq_A2780_Human1.31747264
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29932511
53RNF2_27304074_Chip-Seq_NSC_Mouse1.27988000
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27111083
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26895861
56STAT3_23295773_ChIP-Seq_U87_Human1.25933891
57BCAT_22108803_ChIP-Seq_LS180_Human1.25619971
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.23379819
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.22820960
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22403216
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20180510
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19664515
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19651955
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19518700
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19034704
66NCOR_22424771_ChIP-Seq_293T_Human1.18199051
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17247219
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17089169
69TCF4_23295773_ChIP-Seq_U87_Human1.16964939
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16299756
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12276730
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10485312
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.08565258
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06510907
75TCF4_22108803_ChIP-Seq_LS180_Human1.06419994
76HOXB7_26014856_ChIP-Seq_BT474_Human1.06066701
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.05008082
78P53_22387025_ChIP-Seq_ESCs_Mouse1.04967093
79REST_21632747_ChIP-Seq_MESCs_Mouse1.02461257
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01201867
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00353989
82TBL1_22424771_ChIP-Seq_293T_Human0.98512302
83ETS1_20019798_ChIP-Seq_JURKAT_Human0.98444615
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97462740
85STAT3_18555785_Chip-Seq_ESCs_Mouse0.95404470
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.95373004
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95343609
88FLI1_21867929_ChIP-Seq_TH2_Mouse0.95065449
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.94736539
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.94345336
91GATA1_22025678_ChIP-Seq_K562_Human0.94016868
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93658613
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93575661
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93049000
95AR_20517297_ChIP-Seq_VCAP_Human0.91649577
96TAF2_19829295_ChIP-Seq_ESCs_Human0.91128165
97ERG_20517297_ChIP-Seq_VCAP_Human0.90385540
98RUNX2_22187159_ChIP-Seq_PCA_Human0.89361046
99CBP_21632823_ChIP-Seq_H3396_Human0.89102975
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88274687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002160_abnormal_reproductive_system4.42879572
2MP0004147_increased_porphyrin_level3.87262072
3MP0001188_hyperpigmentation3.32672320
4MP0009379_abnormal_foot_pigmentation3.14320856
5MP0003136_yellow_coat_color2.98821395
6MP0010386_abnormal_urinary_bladder2.69988148
7MP0003123_paternal_imprinting2.68421062
8MP0003787_abnormal_imprinting2.57288014
9MP0005389_reproductive_system_phenotype2.51450829
10MP0004885_abnormal_endolymph2.41807595
11MP0005075_abnormal_melanosome_morpholog2.40128256
12MP0000569_abnormal_digit_pigmentation2.38928389
13MP0003718_maternal_effect2.29674368
14MP0006276_abnormal_autonomic_nervous2.26933115
15MP0005464_abnormal_platelet_physiology2.19645036
16MP0005174_abnormal_tail_pigmentation2.10038217
17MP0008877_abnormal_DNA_methylation2.05897594
18MP0001485_abnormal_pinna_reflex2.05423521
19MP0003878_abnormal_ear_physiology1.99033825
20MP0005377_hearing/vestibular/ear_phenot1.99033825
21MP0003011_delayed_dark_adaptation1.95253632
22MP0002638_abnormal_pupillary_reflex1.94083376
23MP0006292_abnormal_olfactory_placode1.89962450
24MP0001664_abnormal_digestion1.86337775
25MP0005410_abnormal_fertilization1.81494196
26MP0002837_dystrophic_cardiac_calcinosis1.77571180
27MP0006072_abnormal_retinal_apoptosis1.77362831
28MP0004130_abnormal_muscle_cell1.75224766
29MP0002938_white_spotting1.71184134
30MP0008872_abnormal_physiological_respon1.68643836
31MP0002736_abnormal_nociception_after1.66215792
32MP0005551_abnormal_eye_electrophysiolog1.65717674
33MP0008004_abnormal_stomach_pH1.63772910
34MP0001873_stomach_inflammation1.58533686
35MP0002876_abnormal_thyroid_physiology1.55069171
36MP0000230_abnormal_systemic_arterial1.53817603
37MP0004134_abnormal_chest_morphology1.53655646
38MP0002095_abnormal_skin_pigmentation1.51938145
39MP0002272_abnormal_nervous_system1.44741999
40MP0002234_abnormal_pharynx_morphology1.43055434
41MP0004381_abnormal_hair_follicle1.42869447
42MP0005084_abnormal_gallbladder_morpholo1.38518350
43MP0000372_irregular_coat_pigmentation1.38303079
44MP0005253_abnormal_eye_physiology1.38195056
45MP0003950_abnormal_plasma_membrane1.32702292
46MP0002909_abnormal_adrenal_gland1.29623748
47MP0003890_abnormal_embryonic-extraembry1.25081556
48MP0001501_abnormal_sleep_pattern1.22885471
49MP0003119_abnormal_digestive_system1.22366601
50MP0001968_abnormal_touch/_nociception1.20465432
51MP0005645_abnormal_hypothalamus_physiol1.17487514
52MP0003880_abnormal_central_pattern1.15141515
53MP0010329_abnormal_lipoprotein_level1.14765962
54MP0000465_gastrointestinal_hemorrhage1.10722971
55MP0005670_abnormal_white_adipose1.09740747
56MP0003186_abnormal_redox_activity1.05735105
57MP0001970_abnormal_pain_threshold1.05418881
58MP0005448_abnormal_energy_balance1.04832060
59MP0003806_abnormal_nucleotide_metabolis1.04545269
60MP0002693_abnormal_pancreas_physiology1.02616591
61MP0002928_abnormal_bile_duct1.00854341
62MP0005310_abnormal_salivary_gland0.96185153
63MP0004145_abnormal_muscle_electrophysio0.93934614
64MP0001293_anophthalmia0.93659736
65MP0009046_muscle_twitch0.92762585
66MP0009745_abnormal_behavioral_response0.90945227
67MP0006036_abnormal_mitochondrial_physio0.90809169
68MP0005167_abnormal_blood-brain_barrier0.90804191
69MP0001905_abnormal_dopamine_level0.90220144
70MP0002557_abnormal_social/conspecific_i0.88787851
71MP0002396_abnormal_hematopoietic_system0.87187003
72MP0004133_heterotaxia0.86628982
73MP0002210_abnormal_sex_determination0.85221756
74MP0000631_abnormal_neuroendocrine_gland0.84148137
75MP0003121_genomic_imprinting0.82757026
76MP0004043_abnormal_pH_regulation0.81452043
77MP0004742_abnormal_vestibular_system0.80697485
78MP0005535_abnormal_body_temperature0.80231899
79MP0003724_increased_susceptibility_to0.78305911
80MP0001529_abnormal_vocalization0.77184452
81MP0005085_abnormal_gallbladder_physiolo0.77001420
82MP0004142_abnormal_muscle_tone0.76895223
83MP0003698_abnormal_male_reproductive0.76670102
84MP0000538_abnormal_urinary_bladder0.76188679
85MP0001879_abnormal_lymphatic_vessel0.75927737
86MP0001919_abnormal_reproductive_system0.75194190
87MP0001663_abnormal_digestive_system0.73969864
88MP0008775_abnormal_heart_ventricle0.73230892
89MP0003195_calcinosis0.72384208
90MP0002067_abnormal_sensory_capabilities0.71820347
91MP0001764_abnormal_homeostasis0.71279169
92MP0001756_abnormal_urination0.68323082
93MP0004215_abnormal_myocardial_fiber0.67323923
94MP0005646_abnormal_pituitary_gland0.67234588
95MP0005266_abnormal_metabolism0.67163100
96MP0002733_abnormal_thermal_nociception0.66914164
97MP0004924_abnormal_behavior0.66213830
98MP0005386_behavior/neurological_phenoty0.66213830
99MP0005332_abnormal_amino_acid0.65609982
100MP0003879_abnormal_hair_cell0.65341903

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.38332381
2Increased hepatocellular lipid droplets (HP:0006565)3.94425614
3Pancreatic fibrosis (HP:0100732)3.86775801
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.75434539
5Aplasia/Hypoplasia of the tibia (HP:0005772)3.72305935
6Abnormal ciliary motility (HP:0012262)3.70865938
7Congenital, generalized hypertrichosis (HP:0004540)3.63024318
8Abnormal respiratory epithelium morphology (HP:0012253)3.57103138
9Abnormal respiratory motile cilium morphology (HP:0005938)3.57103138
10Renal Fanconi syndrome (HP:0001994)3.55099530
11Pancreatic cysts (HP:0001737)3.50694787
12True hermaphroditism (HP:0010459)3.38034732
13Decreased central vision (HP:0007663)3.24676514
14Congenital stationary night blindness (HP:0007642)3.15729262
15Agitation (HP:0000713)3.04392521
16Abnormal rod and cone electroretinograms (HP:0008323)2.99857583
17Hyperglycinemia (HP:0002154)2.99480520
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.94119237
19Absent/shortened dynein arms (HP:0200106)2.94119237
20Short tibia (HP:0005736)2.92374896
21Prolonged bleeding time (HP:0003010)2.88936369
22Medial flaring of the eyebrow (HP:0010747)2.86845998
23Abnormality of the phalanges of the 2nd finger (HP:0009541)2.81358867
24Papilledema (HP:0001085)2.79448515
25Abnormal respiratory motile cilium physiology (HP:0012261)2.73825501
26Metaphyseal dysplasia (HP:0100255)2.70177322
27Abnormality of midbrain morphology (HP:0002418)2.68891971
28Molar tooth sign on MRI (HP:0002419)2.68891971
29Congenital primary aphakia (HP:0007707)2.66520849
30Exertional dyspnea (HP:0002875)2.65829207
31Respiratory difficulties (HP:0002880)2.65158786
32Increased CSF lactate (HP:0002490)2.64045592
33Gait imbalance (HP:0002141)2.63163516
34Acute lymphatic leukemia (HP:0006721)2.63012484
35Nephrogenic diabetes insipidus (HP:0009806)2.59476313
36Attenuation of retinal blood vessels (HP:0007843)2.48404804
37Mitochondrial inheritance (HP:0001427)2.41469278
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.41209967
39Arthropathy (HP:0003040)2.35667735
40Thyroid-stimulating hormone excess (HP:0002925)2.34629693
41Cerebral palsy (HP:0100021)2.33006521
42Congenital hepatic fibrosis (HP:0002612)2.29619675
43Abnormality of the renal cortex (HP:0011035)2.28093293
44Asplenia (HP:0001746)2.27921758
45Metabolic alkalosis (HP:0200114)2.24496688
46Anencephaly (HP:0002323)2.22264452
47Chronic sinusitis (HP:0011109)2.22005941
48Dyschromatopsia (HP:0007641)2.21741286
49Rhinitis (HP:0012384)2.21374351
50Progressive microcephaly (HP:0000253)2.16150388
51Increased muscle lipid content (HP:0009058)2.15093180
52Abnormality of renal resorption (HP:0011038)2.09775562
53Renal cortical cysts (HP:0000803)2.09065628
54Cystic liver disease (HP:0006706)2.08726374
55Genital tract atresia (HP:0001827)2.08563568
56Abnormality of the labia minora (HP:0012880)2.05560234
57Abnormality of alanine metabolism (HP:0010916)2.04467316
58Hyperalaninemia (HP:0003348)2.04467316
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04467316
60Genetic anticipation (HP:0003743)2.04046835
61Increased intramyocellular lipid droplets (HP:0012240)2.01996067
62Abnormality of the pubic bones (HP:0003172)2.01132902
63Abnormality of the renal medulla (HP:0100957)1.99713890
64Protruding tongue (HP:0010808)1.97869269
65Nephronophthisis (HP:0000090)1.97644631
66Large for gestational age (HP:0001520)1.96551651
67Hypoplasia of the pons (HP:0012110)1.92205081
68Short hallux (HP:0010109)1.92110408
69Vaginal atresia (HP:0000148)1.91717037
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89223186
71Hyperphosphaturia (HP:0003109)1.89059529
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88740137
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88614576
74Neonatal respiratory distress (HP:0002643)1.88605862
75Menstrual irregularities (HP:0000858)1.88324563
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.86456980
77Acute encephalopathy (HP:0006846)1.86179046
78Abnormal pupillary function (HP:0007686)1.85561129
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85482080
80Acute necrotizing encephalopathy (HP:0006965)1.84023842
81Hypoplastic ischia (HP:0003175)1.82574883
82Abnormality of the pons (HP:0007361)1.81176592
83Abnormality of urine glucose concentration (HP:0011016)1.79792541
84Glycosuria (HP:0003076)1.79792541
85Aplasia/Hypoplasia of the hallux (HP:0008362)1.78540802
86Abnormal platelet volume (HP:0011876)1.77450370
87Furrowed tongue (HP:0000221)1.77375175
88Aplasia/Hypoplasia of the patella (HP:0006498)1.76043091
89Sclerocornea (HP:0000647)1.74554120
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74153974
91Febrile seizures (HP:0002373)1.72954777
92Left ventricular hypertrophy (HP:0001712)1.72855987
93Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72361152
94Pendular nystagmus (HP:0012043)1.72063572
95Decreased circulating renin level (HP:0003351)1.71738810
96Increased mean platelet volume (HP:0011877)1.71635010
97Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70498046
98Mesomelia (HP:0003027)1.70007368
99Male pseudohermaphroditism (HP:0000037)1.69782571
100Gaze-evoked nystagmus (HP:0000640)1.69622156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.90744546
2FRK5.18811045
3CAMKK24.44152495
4ACVR1B3.01392975
5TAF12.57811261
6TNIK2.34119156
7ADRBK22.27130339
8BMPR1B2.26306848
9ZAK2.04553939
10TAOK31.84277324
11NUAK11.76981962
12TLK11.66653730
13EPHA41.57878061
14ADRBK11.45853475
15TRIM281.45403094
16PASK1.42957689
17AKT31.37277544
18CAMKK11.32987963
19CDC71.21925307
20VRK11.20583123
21TXK1.20189272
22BRSK21.19070972
23SRPK11.18277892
24MST41.17861514
25VRK21.15474409
26WNK31.13454691
27TGFBR11.11996740
28DYRK31.11873927
29TEC1.08206605
30IRAK30.99587514
31MKNK10.94577518
32CAMK10.92831661
33PINK10.89023584
34BRAF0.88604623
35STK30.87292903
36STK240.87265717
37GRK10.83623637
38GRK70.81853864
39PNCK0.75161925
40BMPR20.73721440
41CASK0.72200056
42MAP3K60.69412512
43BTK0.69017245
44STK160.66463497
45PDK20.66350220
46IKBKB0.66139226
47EIF2AK10.64175471
48RPS6KA40.64104863
49PBK0.62658350
50PRKCQ0.62418969
51FLT30.61337461
52EIF2AK30.60389401
53CDK190.60292840
54GRK50.59893175
55STK390.58718413
56WNK40.57962220
57ARAF0.57385502
58OXSR10.57104107
59MAP2K60.56882966
60MINK10.56624768
61MYLK0.56290997
62MKNK20.54055387
63PAK30.53606492
64PTK2B0.53579662
65ERBB30.52133069
66ILK0.51956395
67MATK0.51763517
68MAP3K130.48591420
69NEK20.48380161
70INSRR0.48283511
71PLK20.46649746
72CCNB10.44489775
73DMPK0.44103072
74RPS6KA50.43531865
75PLK30.42817914
76IRAK10.41992270
77SGK20.39127731
78CAMK1G0.38801566
79CSNK1A10.37984711
80PRKCG0.35626401
81SYK0.35407262
82MAPK40.35225043
83FES0.35175583
84PRKCE0.35091261
85NME10.33890506
86CSNK1G30.33590889
87PRKG10.32469231
88DAPK20.31500839
89RPS6KA60.30641390
90CAMK2A0.30481117
91RIPK40.30313170
92HCK0.30203659
93STK40.30194550
94ITK0.29341107
95CSNK1G20.29211647
96AURKA0.28672986
97CDK30.28609208
98CAMK40.28409828
99CSF1R0.28305613
100PRKACA0.28156938

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.47589660
2Butanoate metabolism_Homo sapiens_hsa006503.34382831
3Ribosome_Homo sapiens_hsa030103.34041025
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14536945
5Linoleic acid metabolism_Homo sapiens_hsa005912.97565280
6Phototransduction_Homo sapiens_hsa047442.17197618
7Tryptophan metabolism_Homo sapiens_hsa003802.17186903
8Selenocompound metabolism_Homo sapiens_hsa004502.16769233
9Oxidative phosphorylation_Homo sapiens_hsa001902.14415633
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.06913550
11Protein export_Homo sapiens_hsa030601.99762294
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.91769607
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89241296
14Sulfur metabolism_Homo sapiens_hsa009201.84166334
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83098302
16Homologous recombination_Homo sapiens_hsa034401.81044065
17Arachidonic acid metabolism_Homo sapiens_hsa005901.81009029
18Parkinsons disease_Homo sapiens_hsa050121.71318653
19Fat digestion and absorption_Homo sapiens_hsa049751.67790933
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64727861
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56068523
22One carbon pool by folate_Homo sapiens_hsa006701.53795330
23Nitrogen metabolism_Homo sapiens_hsa009101.52728395
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.48310357
25Glycerolipid metabolism_Homo sapiens_hsa005611.45453832
26Basal transcription factors_Homo sapiens_hsa030221.43469941
27Sulfur relay system_Homo sapiens_hsa041221.34652630
28Huntingtons disease_Homo sapiens_hsa050161.32724093
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28647644
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28184573
31Sphingolipid metabolism_Homo sapiens_hsa006001.26833940
32Ether lipid metabolism_Homo sapiens_hsa005651.23590773
33Serotonergic synapse_Homo sapiens_hsa047261.23391809
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22993312
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20254648
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.12470780
37Fatty acid degradation_Homo sapiens_hsa000711.09141234
38Peroxisome_Homo sapiens_hsa041461.08460140
39Retinol metabolism_Homo sapiens_hsa008301.05152477
40Propanoate metabolism_Homo sapiens_hsa006401.04438415
41Olfactory transduction_Homo sapiens_hsa047401.00995276
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99945905
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96732591
44Alzheimers disease_Homo sapiens_hsa050100.96682981
45ABC transporters_Homo sapiens_hsa020100.95894790
46Cardiac muscle contraction_Homo sapiens_hsa042600.94485795
47Glutathione metabolism_Homo sapiens_hsa004800.92921346
48RNA polymerase_Homo sapiens_hsa030200.92843914
49Nicotine addiction_Homo sapiens_hsa050330.91953017
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.91045575
51Insulin secretion_Homo sapiens_hsa049110.90933661
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90912771
53Pyrimidine metabolism_Homo sapiens_hsa002400.90242757
54Chemical carcinogenesis_Homo sapiens_hsa052040.89203241
55Salivary secretion_Homo sapiens_hsa049700.86583700
56Morphine addiction_Homo sapiens_hsa050320.86087389
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84508631
58Steroid biosynthesis_Homo sapiens_hsa001000.84166471
59Purine metabolism_Homo sapiens_hsa002300.82113835
60Alcoholism_Homo sapiens_hsa050340.81550718
61Glutamatergic synapse_Homo sapiens_hsa047240.80723489
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78784161
63Long-term depression_Homo sapiens_hsa047300.77420451
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77285749
65Histidine metabolism_Homo sapiens_hsa003400.75794108
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74982320
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74770971
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74560480
69Fatty acid metabolism_Homo sapiens_hsa012120.74342890
70Metabolic pathways_Homo sapiens_hsa011000.64606180
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.64454035
72Platelet activation_Homo sapiens_hsa046110.63890671
73Taste transduction_Homo sapiens_hsa047420.63869088
74Pyruvate metabolism_Homo sapiens_hsa006200.63208330
75Systemic lupus erythematosus_Homo sapiens_hsa053220.62698749
76Ovarian steroidogenesis_Homo sapiens_hsa049130.61182393
77Starch and sucrose metabolism_Homo sapiens_hsa005000.60745038
78Pancreatic secretion_Homo sapiens_hsa049720.59407212
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59183141
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.58166189
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.57261144
82Nucleotide excision repair_Homo sapiens_hsa034200.56129694
83Base excision repair_Homo sapiens_hsa034100.52849548
84Circadian entrainment_Homo sapiens_hsa047130.52428882
85beta-Alanine metabolism_Homo sapiens_hsa004100.51392010
86Type I diabetes mellitus_Homo sapiens_hsa049400.51305301
87Cholinergic synapse_Homo sapiens_hsa047250.49925078
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49884179
89RNA degradation_Homo sapiens_hsa030180.49493313
90GABAergic synapse_Homo sapiens_hsa047270.49054946
91Calcium signaling pathway_Homo sapiens_hsa040200.48688296
92Amphetamine addiction_Homo sapiens_hsa050310.46494464
93Proteasome_Homo sapiens_hsa030500.46083387
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37333964
95RNA transport_Homo sapiens_hsa030130.36812975
96Regulation of autophagy_Homo sapiens_hsa041400.36528472
97Circadian rhythm_Homo sapiens_hsa047100.36020336
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34218106
99Mineral absorption_Homo sapiens_hsa049780.31844700
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31581300

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