ICAM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.69636239
2synaptic vesicle maturation (GO:0016188)6.51573517
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.45314495
4locomotory exploration behavior (GO:0035641)6.39402068
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.81390380
6vocalization behavior (GO:0071625)5.71259904
7regulation of glutamate receptor signaling pathway (GO:1900449)5.53665190
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45663284
9regulation of neuronal synaptic plasticity (GO:0048168)5.39257422
10synaptic vesicle exocytosis (GO:0016079)5.38920629
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.36769768
12regulation of long-term neuronal synaptic plasticity (GO:0048169)5.24526273
13glutamate secretion (GO:0014047)5.21741776
14ionotropic glutamate receptor signaling pathway (GO:0035235)5.14397033
15regulation of synapse structural plasticity (GO:0051823)5.08650974
16negative regulation of erythrocyte differentiation (GO:0045647)5.00737929
17protein localization to synapse (GO:0035418)4.99803361
18exploration behavior (GO:0035640)4.92139541
19regulation of synaptic vesicle exocytosis (GO:2000300)4.83784116
20dendritic spine morphogenesis (GO:0060997)4.63408625
21synaptic transmission, glutamatergic (GO:0035249)4.59047795
22cytoskeletal anchoring at plasma membrane (GO:0007016)4.58666891
23neurotransmitter-gated ion channel clustering (GO:0072578)4.51816342
24regulation of synaptic vesicle transport (GO:1902803)4.44633753
25regulation of dendritic spine morphogenesis (GO:0061001)4.40915216
26glutamate receptor signaling pathway (GO:0007215)4.39784034
27long-term memory (GO:0007616)4.39288582
28neuronal action potential propagation (GO:0019227)4.35123312
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.30422685
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29640690
31neurotransmitter secretion (GO:0007269)4.27977230
32positive regulation of membrane potential (GO:0045838)4.27567769
33regulation of synaptic plasticity (GO:0048167)4.19516525
34neuron-neuron synaptic transmission (GO:0007270)4.16335540
35amino acid import (GO:0043090)4.15241374
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08941038
37layer formation in cerebral cortex (GO:0021819)4.04425674
38G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.03781326
39regulation of postsynaptic membrane potential (GO:0060078)3.97498361
40cerebellar granule cell differentiation (GO:0021707)3.92590771
41negative regulation of dendrite morphogenesis (GO:0050774)3.90858484
42positive regulation of synapse maturation (GO:0090129)3.86815331
43neuromuscular process controlling balance (GO:0050885)3.86162340
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.85807590
45potassium ion homeostasis (GO:0055075)3.84851139
46phosphorelay signal transduction system (GO:0000160)3.84699342
47dendritic spine organization (GO:0097061)3.84479903
48neuron cell-cell adhesion (GO:0007158)3.84246417
49cellular potassium ion homeostasis (GO:0030007)3.77739134
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.76233910
51positive regulation of neurotransmitter secretion (GO:0001956)3.76181137
52regulation of early endosome to late endosome transport (GO:2000641)3.74827690
53proline transport (GO:0015824)3.74352769
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.68494419
55long-term synaptic potentiation (GO:0060291)3.63476154
56sodium ion export (GO:0071436)3.61795005
57gamma-aminobutyric acid transport (GO:0015812)3.61701698
58positive regulation of neurotransmitter transport (GO:0051590)3.61203523
59behavioral defense response (GO:0002209)3.60494214
60behavioral fear response (GO:0001662)3.60494214
61regulation of dendritic spine development (GO:0060998)3.58714857
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.58636605
63positive regulation of dendritic spine development (GO:0060999)3.57555153
64prepulse inhibition (GO:0060134)3.57319145
65activation of protein kinase A activity (GO:0034199)3.56867148
66transmission of nerve impulse (GO:0019226)3.56487005
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.50965249
68auditory behavior (GO:0031223)3.49914608
69regulation of vesicle fusion (GO:0031338)3.42997228
70neuronal ion channel clustering (GO:0045161)3.38773886
71regulation of neurotransmitter secretion (GO:0046928)3.38080610
72neurotransmitter transport (GO:0006836)3.35657352
73synaptic vesicle endocytosis (GO:0048488)3.34176345
74regulation of female receptivity (GO:0045924)3.31972542
75neuron recognition (GO:0008038)3.30653198
76response to auditory stimulus (GO:0010996)3.29173597
77learning (GO:0007612)3.29084873
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28009441
79chemosensory behavior (GO:0007635)3.27982695
80membrane depolarization (GO:0051899)3.27725100
81L-amino acid import (GO:0043092)3.26203120
82fear response (GO:0042596)3.25454006
83cerebellar Purkinje cell layer development (GO:0021680)3.24259450
84regulation of glutamate secretion (GO:0014048)3.24070806
85cell communication by electrical coupling (GO:0010644)3.22644935
86regulation of neurotransmitter levels (GO:0001505)3.20786729
87regulation of ARF protein signal transduction (GO:0032012)3.20283930
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19663031
89regulation of synaptic transmission (GO:0050804)3.18744666
90regulation of neurotransmitter transport (GO:0051588)3.18276042
91positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.17916506
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17845068
93positive regulation of synaptic transmission (GO:0050806)3.17004775
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13494633
95glycine transport (GO:0015816)3.12382915
96response to histamine (GO:0034776)3.11719363
97negative regulation of amino acid transport (GO:0051956)3.11076364
98gamma-aminobutyric acid signaling pathway (GO:0007214)3.09891447
99positive regulation of fibroblast migration (GO:0010763)3.08241163
100COPI coating of Golgi vesicle (GO:0048205)3.06383401
101Golgi transport vesicle coating (GO:0048200)3.06383401
102dendrite morphogenesis (GO:0048813)3.06350597
103innervation (GO:0060384)3.06159397
104positive regulation of protein dephosphorylation (GO:0035307)3.06067547
105regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05449785
106visual learning (GO:0008542)3.05416646
107neuromuscular process (GO:0050905)3.04583665
108neuromuscular process controlling posture (GO:0050884)3.04555727
109axonal fasciculation (GO:0007413)3.03196146
110mannose metabolic process (GO:0006013)3.02265203
111response to amphetamine (GO:0001975)3.01584800
112regulation of synapse maturation (GO:0090128)3.00184009
113membrane depolarization during action potential (GO:0086010)3.00094549
114cerebellar Purkinje cell differentiation (GO:0021702)3.00060000
115vesicle transport along microtubule (GO:0047496)2.99480677
116synaptic transmission (GO:0007268)2.99183101
117dopamine receptor signaling pathway (GO:0007212)2.98833057
118cellular sodium ion homeostasis (GO:0006883)2.98423735
119proline biosynthetic process (GO:0006561)2.96093605
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95956133
121regulation of translational fidelity (GO:0006450)2.95818048
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94138009
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89927513
124cellular response to thyroid hormone stimulus (GO:0097067)2.86937004
125vesicle docking involved in exocytosis (GO:0006904)2.84345617
126protein retention in ER lumen (GO:0006621)2.83184352
127gas transport (GO:0015669)2.80410046
128protein localization to endosome (GO:0036010)2.80403917
129anatomical structure maturation (GO:0071695)2.73747399
130clathrin coat assembly (GO:0048268)2.71485443
131activation of MAPKKK activity (GO:0000185)2.70639307
132regulation of response to osmotic stress (GO:0047484)2.67327559
133cell migration in hindbrain (GO:0021535)2.67286036
134oxygen transport (GO:0015671)2.65701246
135mitochondrion transport along microtubule (GO:0047497)2.62938348
136establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62938348
137regulation of histone H3-K27 methylation (GO:0061085)2.60809446
138protoporphyrinogen IX metabolic process (GO:0046501)2.60138548
139dicarboxylic acid transport (GO:0006835)2.59510182
140vesicle docking (GO:0048278)2.51296037
141activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50488588
142positive regulation of dendrite development (GO:1900006)2.50315304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23398265
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.34725288
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25928237
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24960317
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20574115
6GBX2_23144817_ChIP-Seq_PC3_Human3.12903988
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90630277
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90630277
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.86794659
10REST_21632747_ChIP-Seq_MESCs_Mouse2.86094973
11* LXR_22292898_ChIP-Seq_THP-1_Human2.82789591
12DROSHA_22980978_ChIP-Seq_HELA_Human2.81485356
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73682648
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66936263
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65860674
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60175474
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55235987
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.54325649
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52605919
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45553019
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.44301640
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42607674
23E2F7_22180533_ChIP-Seq_HELA_Human2.41868530
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.37247538
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36866809
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.34644348
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26910553
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.25425159
29MYC_22102868_ChIP-Seq_BL_Human2.23368679
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17631844
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12573047
32GATA1_19941826_ChIP-Seq_K562_Human2.12553365
33KDM2B_26808549_Chip-Seq_DND41_Human2.06021612
34* ELK3_25401928_ChIP-Seq_HUVEC_Human2.04666659
35VDR_21846776_ChIP-Seq_THP-1_Human2.02551914
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00433886
37ZNF263_19887448_ChIP-Seq_K562_Human1.93564946
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92343012
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.91139803
40* NCOR1_26117541_ChIP-Seq_K562_Human1.82701256
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82078689
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81212845
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80560312
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.80499071
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77746536
46* TCF7_22412390_ChIP-Seq_EML_Mouse1.76310264
47RACK7_27058665_Chip-Seq_MCF-7_Human1.75238161
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75088610
49AR_21572438_ChIP-Seq_LNCaP_Human1.74026800
50* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72894433
51P68_20966046_ChIP-Seq_HELA_Human1.69904635
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67402652
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61907814
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61308953
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61288709
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58409897
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.55256088
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.54953672
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54401182
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53452909
61* CREB1_26743006_Chip-Seq_LNCaP_Human1.53296921
62SMC4_20622854_ChIP-Seq_HELA_Human1.53083836
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51446494
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.45742987
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44965397
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42778994
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.41404374
68SMAD4_21799915_ChIP-Seq_A2780_Human1.40393609
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39973916
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.38531961
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37796982
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36336508
73* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34983136
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34974889
75CLOCK_20551151_ChIP-Seq_293T_Human1.34761922
76KDM2B_26808549_Chip-Seq_K562_Human1.34268446
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.33109213
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33108125
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31191186
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31067204
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.30794973
82* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29933901
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28910199
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28101817
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27835190
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27593370
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27201512
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25526302
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25426338
90* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25330245
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24561633
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22236237
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21037728
94* GATA1_19941827_ChIP-Seq_MEL_Mouse1.20570492
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20399250
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.20336508
97* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19851390
98GATA1_22025678_ChIP-Seq_K562_Human1.19599047
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19222537
100AR_19668381_ChIP-Seq_PC3_Human1.19040805
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.18346046
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16944143
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16140926
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15359087
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.15248730
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15078762
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14956362
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.13843172
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11854605
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11274370
111* GATA2_19941826_ChIP-Seq_K562_Human1.10530168
112* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10512627
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10481349
114ZNF274_21170338_ChIP-Seq_K562_Hela1.10333018
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10061720
116AR_25329375_ChIP-Seq_VCAP_Human1.09446286
117SCL_19346495_ChIP-Seq_HPC-7_Human1.09393874
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09106786
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08698432
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.06341989
121CTCF_27219007_Chip-Seq_Bcells_Human1.05717062
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04354448
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04056989
124ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03847206
125STAT3_23295773_ChIP-Seq_U87_Human1.03029453
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02606845
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02290996
128GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01916210
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01831884
130MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01811097
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01745719
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01703778
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.01606451
134P300_19829295_ChIP-Seq_ESCs_Human1.01231454
135TAF15_26573619_Chip-Seq_HEK293_Human0.99491619
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99017943
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95243373
138SMAD_19615063_ChIP-ChIP_OVARY_Human0.94553900
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93816740
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93115028
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.92870665
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92606583
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92518994
144TCF4_23295773_ChIP-Seq_U87_Human0.91372232
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.90967175
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.89833747
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89442125
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.89049636
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88963085
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.88541555
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88502068
152RXR_22108803_ChIP-Seq_LS180_Human0.88192739
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88016136
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.87470503
155TP53_16413492_ChIP-PET_HCT116_Human0.87367321
156AHR_22903824_ChIP-Seq_MCF-7_Human0.86780762
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84577161
158* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81769030
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80509986
160* KLF4_19829295_ChIP-Seq_ESCs_Human0.79643586
161DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79416292
162RUNX2_22187159_ChIP-Seq_PCA_Human0.78575583
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.77725111
164CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77183378
165SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76582879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.20708859
2MP0003880_abnormal_central_pattern4.98943934
3* MP0003635_abnormal_synaptic_transmissio4.53048461
4MP0002822_catalepsy4.43777690
5MP0009745_abnormal_behavioral_response3.77715398
6MP0004270_analgesia3.74211389
7* MP0002063_abnormal_learning/memory/cond3.72642423
8MP0002064_seizures3.28682371
9MP0002572_abnormal_emotion/affect_behav2.92529561
10MP0003705_abnormal_hypodermis_morpholog2.89348783
11MP0001968_abnormal_touch/_nociception2.81617776
12MP0001486_abnormal_startle_reflex2.66062043
13MP0009046_muscle_twitch2.62129657
14MP0005423_abnormal_somatic_nervous2.55946733
15MP0002272_abnormal_nervous_system2.55018974
16MP0004147_increased_porphyrin_level2.47102779
17MP0001501_abnormal_sleep_pattern2.33735300
18MP0002734_abnormal_mechanical_nocicepti2.32756509
19MP0005451_abnormal_body_composition2.30009006
20MP0002736_abnormal_nociception_after2.15860129
21MP0002735_abnormal_chemical_nociception2.06260533
22MP0009780_abnormal_chondrocyte_physiolo2.06122413
23MP0001440_abnormal_grooming_behavior2.05322272
24MP0005058_abnormal_lysosome_morphology2.01742109
25MP0003656_abnormal_erythrocyte_physiolo1.96181034
26MP0004858_abnormal_nervous_system1.93776025
27MP0003329_amyloid_beta_deposits1.92371322
28MP0009278_abnormal_bone_marrow1.91155396
29MP0001348_abnormal_lacrimal_gland1.89377434
30MP0001970_abnormal_pain_threshold1.86047106
31MP0008569_lethality_at_weaning1.85881367
32MP0004811_abnormal_neuron_physiology1.85823828
33MP0002733_abnormal_thermal_nociception1.81893553
34MP0002909_abnormal_adrenal_gland1.79071290
35MP0002877_abnormal_melanocyte_morpholog1.71611870
36MP0003879_abnormal_hair_cell1.70923699
37MP0002557_abnormal_social/conspecific_i1.66694895
38MP0003303_peritoneal_inflammation1.63738135
39MP0002067_abnormal_sensory_capabilities1.63050239
40MP0003075_altered_response_to1.61453253
41MP0005646_abnormal_pituitary_gland1.59363047
42MP0004885_abnormal_endolymph1.58317640
43MP0000678_abnormal_parathyroid_gland1.56076715
44MP0004924_abnormal_behavior1.55399957
45MP0005386_behavior/neurological_phenoty1.55399957
46MP0000778_abnormal_nervous_system1.52552878
47MP0001545_abnormal_hematopoietic_system1.51922858
48MP0005397_hematopoietic_system_phenotyp1.51922858
49MP0003123_paternal_imprinting1.50307154
50MP0002184_abnormal_innervation1.50211985
51MP0000955_abnormal_spinal_cord1.45244647
52MP0005076_abnormal_cell_differentiation1.43784283
53MP0003633_abnormal_nervous_system1.41806004
54MP0002066_abnormal_motor_capabilities/c1.37343678
55MP0003787_abnormal_imprinting1.33783451
56MP0002882_abnormal_neuron_morphology1.32745479
57MP0009840_abnormal_foam_cell1.30086016
58MP0001529_abnormal_vocalization1.29032157
59MP0008438_abnormal_cutaneous_collagen1.25000402
60MP0001984_abnormal_olfaction1.22904057
61MP0001905_abnormal_dopamine_level1.22624974
62MP0010234_abnormal_vibrissa_follicle1.21573707
63MP0003631_nervous_system_phenotype1.16385939
64MP0008260_abnormal_autophagy1.13137846
65MP0001502_abnormal_circadian_rhythm1.13096395
66MP0001177_atelectasis1.10507435
67MP0008874_decreased_physiological_sensi1.08537838
68MP0008872_abnormal_physiological_respon1.06964448
69MP0008961_abnormal_basal_metabolism1.04748543
70MP0003566_abnormal_cell_adhesion1.04201292
71MP0002152_abnormal_brain_morphology1.03636426
72MP0005167_abnormal_blood-brain_barrier1.00238294
73MP0003111_abnormal_nucleus_morphology0.99701431
74MP0000747_muscle_weakness0.98426905
75MP0004142_abnormal_muscle_tone0.97126780
76MP0002069_abnormal_eating/drinking_beha0.96250107
77MP0000681_abnormal_thyroid_gland0.96024736
78MP0000751_myopathy0.95876261
79MP0003453_abnormal_keratinocyte_physiol0.95394595
80MP0003690_abnormal_glial_cell0.95070918
81MP0004510_myositis0.93240279
82MP0000604_amyloidosis0.92753652
83MP0003283_abnormal_digestive_organ0.92571619
84MP0005645_abnormal_hypothalamus_physiol0.91588908
85MP0005535_abnormal_body_temperature0.89649929
86MP0001346_abnormal_lacrimal_gland0.88825948
87MP0002249_abnormal_larynx_morphology0.88369328
88MP0006276_abnormal_autonomic_nervous0.87623700
89MP0004085_abnormal_heartbeat0.81737822
90MP0004947_skin_inflammation0.81221163
91MP0003045_fibrosis0.80061819
92MP0004808_abnormal_hematopoietic_stem0.79361749
93MP0000920_abnormal_myelination0.78988319
94MP0002090_abnormal_vision0.78508355
95MP0002229_neurodegeneration0.77871708
96MP0005409_darkened_coat_color0.77263184
97MP0001188_hyperpigmentation0.75357780
98MP0005621_abnormal_cell_physiology0.74663739
99MP0000013_abnormal_adipose_tissue0.74277645
100MP0003634_abnormal_glial_cell0.73909577
101MP0003632_abnormal_nervous_system0.73899865
102MP0002089_abnormal_postnatal_growth/wei0.73873382
103MP0000579_abnormal_nail_morphology0.72894086
104MP0000569_abnormal_digit_pigmentation0.72656198
105MP0005166_decreased_susceptibility_to0.66859483
106MP0005394_taste/olfaction_phenotype0.66780902
107MP0005499_abnormal_olfactory_system0.66780902
108MP0001963_abnormal_hearing_physiology0.66468465
109MP0001664_abnormal_digestion0.64014246
110MP0004185_abnormal_adipocyte_glucose0.63272543
111MP0010386_abnormal_urinary_bladder0.63201969
112MP0001849_ear_inflammation0.61633141
113MP0004484_altered_response_of0.61320869
114MP0003122_maternal_imprinting0.60231539
115MP0000858_altered_metastatic_potential0.60198962
116MP0008995_early_reproductive_senescence0.60117214
117MP0000003_abnormal_adipose_tissue0.59510558
118MP0003191_abnormal_cellular_cholesterol0.59453884
119MP0005551_abnormal_eye_electrophysiolog0.58844895
120MP0003137_abnormal_impulse_conducting0.58495487
121MP0001485_abnormal_pinna_reflex0.58221046
122MP0005666_abnormal_adipose_tissue0.56434615
123MP0001730_embryonic_growth_arrest0.55688592
124MP0003091_abnormal_cell_migration0.55216316
125MP0005375_adipose_tissue_phenotype0.54070645
126MP0001765_abnormal_ion_homeostasis0.53934227
127MP0003172_abnormal_lysosome_physiology0.53737281
128MP0004215_abnormal_myocardial_fiber0.53693764
129MP0005623_abnormal_meninges_morphology0.53587098
130MP0002234_abnormal_pharynx_morphology0.53518421
131MP0002752_abnormal_somatic_nervous0.52861617
132MP0004742_abnormal_vestibular_system0.52323900
133MP0003436_decreased_susceptibility_to0.51934554
134MP0000631_abnormal_neuroendocrine_gland0.51779149
135MP0004145_abnormal_muscle_electrophysio0.50300952
136MP0004130_abnormal_muscle_cell0.49167787
137MP0004233_abnormal_muscle_weight0.47274524
138MP0003956_abnormal_body_size0.46556632
139MP0003861_abnormal_nervous_system0.46173617
140MP0010769_abnormal_survival0.46048687
141MP0001943_abnormal_respiration0.44921116

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.86998059
2Focal motor seizures (HP:0011153)8.10105812
3Focal seizures (HP:0007359)6.01158741
4Visual hallucinations (HP:0002367)5.58418221
5Cholecystitis (HP:0001082)5.30776087
6Abnormal gallbladder physiology (HP:0012438)5.30776087
7Epileptic encephalopathy (HP:0200134)4.66834254
8Atonic seizures (HP:0010819)4.22095641
9Reticulocytosis (HP:0001923)4.22029600
10Febrile seizures (HP:0002373)4.16931691
11Action tremor (HP:0002345)4.13710776
12Progressive cerebellar ataxia (HP:0002073)4.03206189
13Impaired vibration sensation in the lower limbs (HP:0002166)3.99096541
14Absence seizures (HP:0002121)3.97439927
15Generalized tonic-clonic seizures (HP:0002069)3.87535867
16Dialeptic seizures (HP:0011146)3.75273995
17Abnormality of the lower motor neuron (HP:0002366)3.73150885
18Poor eye contact (HP:0000817)3.69578615
19Ankle clonus (HP:0011448)3.69136456
20Depression (HP:0000716)3.59476140
21Supranuclear gaze palsy (HP:0000605)3.50950758
22Anxiety (HP:0000739)3.41404298
23Annular pancreas (HP:0001734)3.40399075
24Dysmetria (HP:0001310)3.38625218
25Broad-based gait (HP:0002136)3.37930669
26Urinary bladder sphincter dysfunction (HP:0002839)3.32602591
27Postural instability (HP:0002172)3.32036119
28Gaze-evoked nystagmus (HP:0000640)3.30370024
29Abnormal social behavior (HP:0012433)3.29303118
30Impaired social interactions (HP:0000735)3.29303118
31Torticollis (HP:0000473)3.28974197
32Dysdiadochokinesis (HP:0002075)3.27549055
33Papilledema (HP:0001085)3.19107041
34Amblyopia (HP:0000646)3.15208189
35Focal dystonia (HP:0004373)3.13745770
36Distal upper limb amyotrophy (HP:0007149)3.12025420
37Upper limb amyotrophy (HP:0009129)3.12025420
38Peripheral hypomyelination (HP:0007182)3.03776086
39Hyperthyroidism (HP:0000836)2.99016915
40Mutism (HP:0002300)2.93812157
41Urinary urgency (HP:0000012)2.93627616
42Hyperacusis (HP:0010780)2.93483720
43Polycythemia (HP:0001901)2.91956632
44Stereotypic behavior (HP:0000733)2.86975432
45Abnormal eating behavior (HP:0100738)2.86789009
46Cholelithiasis (HP:0001081)2.82509379
47Truncal ataxia (HP:0002078)2.82330416
48Bowel incontinence (HP:0002607)2.82067380
49Ventricular fibrillation (HP:0001663)2.81396364
50Hand muscle atrophy (HP:0009130)2.80489817
51Impaired smooth pursuit (HP:0007772)2.78999714
52Cerebral inclusion bodies (HP:0100314)2.74070225
53Craniofacial dystonia (HP:0012179)2.73007556
54Abnormality of reticulocytes (HP:0004312)2.71918962
55Abnormal large intestine physiology (HP:0012700)2.70868254
56Intention tremor (HP:0002080)2.68714734
57Bradykinesia (HP:0002067)2.68542641
58Impaired vibratory sensation (HP:0002495)2.67243316
59Genetic anticipation (HP:0003743)2.65246918
60Pointed chin (HP:0000307)2.65138968
61Spastic gait (HP:0002064)2.65035251
62Megalencephaly (HP:0001355)2.60245775
63Neurofibrillary tangles (HP:0002185)2.59088104
64Hemiplegia (HP:0002301)2.56582994
65Hyperventilation (HP:0002883)2.54601181
66Scanning speech (HP:0002168)2.49921430
67Bundle branch block (HP:0011710)2.48738609
68Hemiparesis (HP:0001269)2.43815985
69Ankyloglossia (HP:0010296)2.40453982
70Hammertoe (HP:0001765)2.39937154
71Tetraplegia (HP:0002445)2.39237464
72Abnormality of ocular smooth pursuit (HP:0000617)2.38221757
73Abnormal gallbladder morphology (HP:0012437)2.37428958
74Resting tremor (HP:0002322)2.37403435
75Obstructive sleep apnea (HP:0002870)2.37369171
76Epileptiform EEG discharges (HP:0011182)2.37353925
77Excessive salivation (HP:0003781)2.34962083
78Drooling (HP:0002307)2.34962083
79Diplopia (HP:0000651)2.33656726
80Abnormality of binocular vision (HP:0011514)2.33656726
81Disproportionate tall stature (HP:0001519)2.31741789
82Dysmetric saccades (HP:0000641)2.31170118
83Distal sensory impairment (HP:0002936)2.30537316
84Lower limb amyotrophy (HP:0007210)2.29655020
85Diminished motivation (HP:0000745)2.26688050
86Insomnia (HP:0100785)2.24590727
87Upper limb muscle weakness (HP:0003484)2.24360219
88Incomplete penetrance (HP:0003829)2.23639324
89Progressive inability to walk (HP:0002505)2.23150389
90Distal lower limb amyotrophy (HP:0008944)2.22368663
91Lower limb muscle weakness (HP:0007340)2.20908811
92Lower limb asymmetry (HP:0100559)2.20068204
93EEG with generalized epileptiform discharges (HP:0011198)2.19281896
94Delusions (HP:0000746)2.15718473
95Flat cornea (HP:0007720)2.15452054
96Generalized myoclonic seizures (HP:0002123)2.14381116
97Status epilepticus (HP:0002133)2.14107436
98Fetal akinesia sequence (HP:0001989)2.12518536
99Hypsarrhythmia (HP:0002521)2.11222510
100Abnormality of the gallbladder (HP:0005264)2.09745600
101Decreased motor nerve conduction velocity (HP:0003431)2.06524178
102Slow saccadic eye movements (HP:0000514)2.06510129
103Hypertensive crisis (HP:0100735)2.06383588
104Abnormal EKG (HP:0003115)2.04277680
105Atelectasis (HP:0100750)2.03053260
106Termporal pattern (HP:0011008)1.99584239
107Insidious onset (HP:0003587)1.99584239
108Rapidly progressive (HP:0003678)1.99082300
109Abnormality of the periventricular white matter (HP:0002518)1.97636623
110Cerebral aneurysm (HP:0004944)1.97368371
111Clonus (HP:0002169)1.96146617
112Absent speech (HP:0001344)1.95149413
113Abnormality of the Achilles tendon (HP:0005109)1.94864991
114Cerebral hypomyelination (HP:0006808)1.94782806
115Apathy (HP:0000741)1.90157803
116Abnormality of the heme biosynthetic pathway (HP:0010472)1.88755362
117Increased circulating renin level (HP:0000848)1.88370373
118Rigidity (HP:0002063)1.87213093
119Premature rupture of membranes (HP:0001788)1.87066725
120Gait ataxia (HP:0002066)1.86280248
121Ulnar bowing (HP:0003031)1.84193018
122Anosmia (HP:0000458)1.82271606
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81986930
124Interstitial pulmonary disease (HP:0006530)1.81255812
125Abnormality of saccadic eye movements (HP:0000570)1.81048964
126Neuronal loss in central nervous system (HP:0002529)1.79781354
127Segmental peripheral demyelination/remyelination (HP:0003481)1.77948879
128Inability to walk (HP:0002540)1.77456152
129Stridor (HP:0010307)1.76791835
130Achilles tendon contracture (HP:0001771)1.76348125
131Abnormality of oral frenula (HP:0000190)1.75122813
132Abnormality of glycolysis (HP:0004366)1.74388180
133Foot dorsiflexor weakness (HP:0009027)1.73597305
134Overriding aorta (HP:0002623)1.72825224
135Spinal canal stenosis (HP:0003416)1.72591710
136Intellectual disability, profound (HP:0002187)1.70423395
137Hyperparathyroidism (HP:0000843)1.69648613
138Elfin facies (HP:0004428)1.67963157
139Abnormality of the tricuspid valve (HP:0001702)1.67882158
140Limb ataxia (HP:0002070)1.67582917
141Truncus arteriosus (HP:0001660)1.67400676
142Aplasia involving bones of the upper limbs (HP:0009823)1.67200219
143Aplasia of the phalanges of the hand (HP:0009802)1.67200219
144Aplasia involving bones of the extremities (HP:0009825)1.67200219
145Hypercortisolism (HP:0001578)1.64804093
146Relative macrocephaly (HP:0004482)1.62551960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.38142958
2NTRK34.77729089
3MAP3K94.07594757
4EEF2K2.95246389
5DAPK22.89279663
6PRKD32.82867907
7KSR22.77921990
8TRIB32.61921119
9MINK12.52083603
10ICK2.31152711
11IRAK32.23360292
12PAK62.21460518
13MAP3K42.19379024
14CDK122.08942727
15RIPK42.08626456
16MARK12.07923937
17CAMKK12.07652713
18ARAF1.99859026
19MAP3K131.98752617
20NTRK21.91396300
21KSR11.85856684
22SMG11.78803242
23MAP2K71.76638358
24DAPK11.76637770
25NTRK11.72875079
26CDK51.61233325
27PRPF4B1.59319062
28FES1.55668341
29TNIK1.53906983
30STK381.42371600
31NME21.38703521
32MAP3K21.38081602
33MAP2K41.36193720
34PLK21.34988404
35TAOK11.31256885
36TYRO31.29234286
37GRK51.28792600
38SIK21.28684321
39RAF11.27610235
40MAP3K121.27092089
41ERN11.22194528
42PTK2B1.19183670
43PRKCG1.17285587
44CAMK11.13521552
45CLK11.01280646
46SIK10.94364784
47PRKCH0.93015998
48CDK190.92857380
49MAPK120.92300479
50CAMK2A0.91999703
51MARK20.89368817
52PINK10.88570647
53UHMK10.88252484
54CDK150.88178762
55MAPK130.88171248
56CDK180.88099632
57MAP3K110.87999458
58ALK0.86656925
59STK110.84978560
60CAMK2B0.84644050
61PDGFRA0.84175108
62PDK10.83049961
63CDK140.81397369
64CDK11A0.77312014
65BMPR20.77117348
66MAP3K10.76817720
67CAMKK20.75530089
68PDPK10.74404810
69SGK4940.73134959
70SGK2230.73134959
71MAP2K30.72916681
72LMTK20.72382347
73PIM20.71331315
74SGK10.70792263
75MTOR0.69490901
76LATS20.68914424
77MAP3K70.67700808
78RET0.67294467
79EIF2AK10.65654117
80MAP3K80.65510243
81IRAK20.64960571
82PAK20.63576159
83PRKG20.61912525
84PNCK0.61169199
85PAK30.59605682
86SGK30.58788056
87NME10.58202120
88DYRK1A0.57296919
89SGK20.56348549
90CCNB10.56263904
91CAMK40.55824291
92BRSK10.55787712
93PHKG10.54749307
94PHKG20.54749307
95TNK20.54689667
96JAK20.54295278
97DMPK0.54237142
98DAPK30.53324465
99NEK60.52152403
100MAP2K10.52093341
101NEK10.51799949
102FGR0.51113741
103RPS6KA20.50615489
104CAMK1D0.50315592
105PKN20.49896880
106RPS6KA30.48959216
107MOS0.48203058
108CASK0.48071853
109PAK10.48031497
110TTN0.47489683
111SCYL20.47228069
112PRKCZ0.46492397
113AKT20.46165748
114FYN0.46114329
115BRAF0.45886248
116CSNK1G20.45017684
117PRKD20.42367383
118MAP2K60.41946614
119MAPKAPK50.41477032
120MAPK100.40709851
121RIPK10.40013834
122BRD40.39834782
123TTK0.39445612
124DDR20.37831174
125JAK10.37415170
126CDC42BPA0.36693172
127PDK20.36503307
128FER0.36075968
129MAPK110.35416163
130OXSR10.35367523
131CAMK2G0.35241150
132TESK10.33685058
133PRKCE0.33565335
134CAMK2D0.33242705
135HIPK20.32771294
136MAPK80.31797604
137TAOK20.31537130
138BMX0.30174259
139PRKCB0.29448974
140* PRKCA0.26724240

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42797130
2Olfactory transduction_Homo sapiens_hsa047403.20132639
3Synaptic vesicle cycle_Homo sapiens_hsa047213.06160917
4Long-term potentiation_Homo sapiens_hsa047202.90631053
5Circadian entrainment_Homo sapiens_hsa047132.86884269
6Amphetamine addiction_Homo sapiens_hsa050312.67060809
7Glutamatergic synapse_Homo sapiens_hsa047242.66642667
8GABAergic synapse_Homo sapiens_hsa047272.57327168
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56380424
10Morphine addiction_Homo sapiens_hsa050322.52950139
11Salivary secretion_Homo sapiens_hsa049702.28508035
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27054886
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25418495
14Dopaminergic synapse_Homo sapiens_hsa047282.17037296
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.05132986
16Cholinergic synapse_Homo sapiens_hsa047252.04686264
17Gastric acid secretion_Homo sapiens_hsa049712.01742064
18Insulin secretion_Homo sapiens_hsa049111.99436546
19Oxytocin signaling pathway_Homo sapiens_hsa049211.82001597
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75450159
21Calcium signaling pathway_Homo sapiens_hsa040201.74727730
22Cocaine addiction_Homo sapiens_hsa050301.72091002
23Renin secretion_Homo sapiens_hsa049241.67796842
24Long-term depression_Homo sapiens_hsa047301.59203018
25GnRH signaling pathway_Homo sapiens_hsa049121.58582170
26Vitamin B6 metabolism_Homo sapiens_hsa007501.57627359
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51992932
28Nitrogen metabolism_Homo sapiens_hsa009101.51411059
29Taste transduction_Homo sapiens_hsa047421.46887585
30Serotonergic synapse_Homo sapiens_hsa047261.46257278
31Glioma_Homo sapiens_hsa052141.36087865
32cAMP signaling pathway_Homo sapiens_hsa040241.35848813
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35779281
34Gap junction_Homo sapiens_hsa045401.34249419
35Chronic myeloid leukemia_Homo sapiens_hsa052201.33151905
36Other glycan degradation_Homo sapiens_hsa005111.29572578
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.24991330
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20370739
39Acute myeloid leukemia_Homo sapiens_hsa052211.18732132
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16324049
41Estrogen signaling pathway_Homo sapiens_hsa049151.16007209
42Type II diabetes mellitus_Homo sapiens_hsa049301.12664492
43Melanogenesis_Homo sapiens_hsa049161.10080539
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09630602
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07196318
46Bladder cancer_Homo sapiens_hsa052191.07149192
47Collecting duct acid secretion_Homo sapiens_hsa049661.06173388
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04927820
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03801449
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02658005
51ErbB signaling pathway_Homo sapiens_hsa040121.02581011
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.01244833
53Biosynthesis of amino acids_Homo sapiens_hsa012301.00768594
54Axon guidance_Homo sapiens_hsa043601.00584224
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00055547
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.95513102
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93545393
58HIF-1 signaling pathway_Homo sapiens_hsa040660.93495393
59Oocyte meiosis_Homo sapiens_hsa041140.91293828
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90781251
61Pentose phosphate pathway_Homo sapiens_hsa000300.88610708
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88460022
63Pancreatic secretion_Homo sapiens_hsa049720.84047191
64Fructose and mannose metabolism_Homo sapiens_hsa000510.83868658
65Cardiac muscle contraction_Homo sapiens_hsa042600.82092625
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81194622
67VEGF signaling pathway_Homo sapiens_hsa043700.80655076
68Dorso-ventral axis formation_Homo sapiens_hsa043200.79037348
69Thyroid hormone synthesis_Homo sapiens_hsa049180.78987355
70Choline metabolism in cancer_Homo sapiens_hsa052310.76773163
71Dilated cardiomyopathy_Homo sapiens_hsa054140.73733887
72Pancreatic cancer_Homo sapiens_hsa052120.71058655
73Prolactin signaling pathway_Homo sapiens_hsa049170.69909746
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.69764178
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68094867
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67759360
77MAPK signaling pathway_Homo sapiens_hsa040100.67208256
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67206229
79Rap1 signaling pathway_Homo sapiens_hsa040150.67022261
80Vibrio cholerae infection_Homo sapiens_hsa051100.64353951
81B cell receptor signaling pathway_Homo sapiens_hsa046620.63732418
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.63075348
83Carbon metabolism_Homo sapiens_hsa012000.61610193
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61016400
85Non-small cell lung cancer_Homo sapiens_hsa052230.59968886
86Phototransduction_Homo sapiens_hsa047440.59791466
87Glucagon signaling pathway_Homo sapiens_hsa049220.59768996
88Ras signaling pathway_Homo sapiens_hsa040140.57692653
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57114185
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56845315
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56399133
92Type I diabetes mellitus_Homo sapiens_hsa049400.56154821
93Bile secretion_Homo sapiens_hsa049760.56055328
94Salmonella infection_Homo sapiens_hsa051320.54991682
95Endocytosis_Homo sapiens_hsa041440.54975311
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.54083292
97Alcoholism_Homo sapiens_hsa050340.53323422
98Lysosome_Homo sapiens_hsa041420.52845366
99mTOR signaling pathway_Homo sapiens_hsa041500.51453307
100AMPK signaling pathway_Homo sapiens_hsa041520.50952201
101Amoebiasis_Homo sapiens_hsa051460.49516220
102Prion diseases_Homo sapiens_hsa050200.49027931
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48685799
104African trypanosomiasis_Homo sapiens_hsa051430.48119090
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47547908
106MicroRNAs in cancer_Homo sapiens_hsa052060.46701535
107Thyroid cancer_Homo sapiens_hsa052160.46652381
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46363134
109TNF signaling pathway_Homo sapiens_hsa046680.45615149
110Inositol phosphate metabolism_Homo sapiens_hsa005620.45260254
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43846019
112Chemokine signaling pathway_Homo sapiens_hsa040620.43242017
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41916135
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39905389
115Endometrial cancer_Homo sapiens_hsa052130.38925595
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37560122
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37051011
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36824704
119Wnt signaling pathway_Homo sapiens_hsa043100.36740229
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35326180
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34493785
122Circadian rhythm_Homo sapiens_hsa047100.32755813
123Renal cell carcinoma_Homo sapiens_hsa052110.32141691
124Insulin signaling pathway_Homo sapiens_hsa049100.32136156
125Ovarian steroidogenesis_Homo sapiens_hsa049130.30970692
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29485816
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28824291
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28250610
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28015016
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27697352
131Platelet activation_Homo sapiens_hsa046110.26761512
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26226733

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