HYPM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein shown to interact with huntingtin, which contains an expanded polyglutamine tract in individuals with Huntington's disease (PMID: 9700202). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.97862585
2spermatid development (GO:0007286)9.94741515
3axonemal dynein complex assembly (GO:0070286)9.85220858
4reproduction (GO:0000003)9.45448748
5motile cilium assembly (GO:0044458)9.12963156
6regulation of cilium movement (GO:0003352)8.20219360
7cilium movement (GO:0003341)8.14047553
8cilium or flagellum-dependent cell motility (GO:0001539)7.93171537
9negative regulation of inclusion body assembly (GO:0090084)7.84770280
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.52162159
11single fertilization (GO:0007338)7.26640744
12sperm capacitation (GO:0048240)7.14973960
13spermatogenesis (GO:0007283)6.96428954
14synaptonemal complex organization (GO:0070193)6.95675758
15male gamete generation (GO:0048232)6.93839939
16synaptonemal complex assembly (GO:0007130)6.89991078
17microtubule depolymerization (GO:0007019)6.84817118
18organic cation transport (GO:0015695)6.71813566
19male meiosis (GO:0007140)6.60878010
20regulation of inclusion body assembly (GO:0090083)6.44727411
21gamete generation (GO:0007276)6.38143585
22fertilization (GO:0009566)6.20604828
23piRNA metabolic process (GO:0034587)6.17477276
24chromosome condensation (GO:0030261)5.85589601
25spermatid nucleus differentiation (GO:0007289)5.84983149
26calcium ion-dependent exocytosis (GO:0017156)5.79847961
27glycerol ether metabolic process (GO:0006662)5.55044500
28sexual reproduction (GO:0019953)5.54853078
29DNA packaging (GO:0006323)5.48447762
30germ cell development (GO:0007281)5.44971294
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.31815305
32ether metabolic process (GO:0018904)5.13120531
33ventricular system development (GO:0021591)5.11512222
34single strand break repair (GO:0000012)5.05922483
35cell recognition (GO:0008037)5.03588323
36multicellular organismal reproductive process (GO:0048609)5.01998165
37regulation of microtubule-based movement (GO:0060632)4.90681353
38microtubule severing (GO:0051013)4.68322594
39chromosome organization involved in meiosis (GO:0070192)4.63874122
40seminiferous tubule development (GO:0072520)4.45954158
41male meiosis I (GO:0007141)4.38101779
42chaperone-mediated protein complex assembly (GO:0051131)4.24513300
43DNA methylation involved in gamete generation (GO:0043046)4.06852701
44left/right pattern formation (GO:0060972)4.04874944
45multicellular organismal development (GO:0007275)4.02903020
46meiotic nuclear division (GO:0007126)3.98306971
47sequestering of actin monomers (GO:0042989)3.94966979
48protein K11-linked deubiquitination (GO:0035871)3.83549627
49microtubule polymerization or depolymerization (GO:0031109)3.64939105
50genitalia morphogenesis (GO:0035112)3.53965743
51meiosis I (GO:0007127)3.51495643
52protein refolding (GO:0042026)3.42861664
53regulation of spindle checkpoint (GO:0090231)3.35179941
54glycolytic process (GO:0006096)3.29975672
55protein polyglutamylation (GO:0018095)3.25258035
56nucleus organization (GO:0006997)3.21505000
57polyamine biosynthetic process (GO:0006596)3.19126975
58nucleoside diphosphate phosphorylation (GO:0006165)3.11366150
59interferon-gamma secretion (GO:0072643)3.10412957
60chromatin silencing (GO:0006342)3.09836346
61alditol metabolic process (GO:0019400)3.07336847
62polyol catabolic process (GO:0046174)3.04849189
63monoubiquitinated protein deubiquitination (GO:0035520)3.04432753
64positive regulation of macrophage activation (GO:0043032)3.03898618
65mitotic sister chromatid cohesion (GO:0007064)3.03071928
66meiotic cell cycle (GO:0051321)3.02456214
67GTP biosynthetic process (GO:0006183)2.97573699
68carnitine transport (GO:0015879)2.87996348
69amino-acid betaine transport (GO:0015838)2.87996348
70RNA destabilization (GO:0050779)2.83267326
71protein localization to cilium (GO:0061512)2.73749818
72regulation of cilium assembly (GO:1902017)2.68428073
73carnitine transmembrane transport (GO:1902603)2.67929924
74RNA localization (GO:0006403)2.67138592
75synapsis (GO:0007129)2.67038070
76UTP biosynthetic process (GO:0006228)2.64845299
77cilium organization (GO:0044782)2.62082889
78meiotic cell cycle process (GO:1903046)2.60587867
79microtubule-based movement (GO:0007018)2.60552754
80mitochondrion degradation (GO:0000422)2.58676897
81cellular component assembly involved in morphogenesis (GO:0010927)2.57451244
82glycerol metabolic process (GO:0006071)2.55659747
83cilium assembly (GO:0042384)2.52595361
84cilium morphogenesis (GO:0060271)2.49179223
85nucleosome disassembly (GO:0006337)2.46885593
86protein-DNA complex disassembly (GO:0032986)2.46885593
87positive regulation of glycolytic process (GO:0045821)2.46363286
88membrane protein intracellular domain proteolysis (GO:0031293)2.45501790
89axoneme assembly (GO:0035082)2.45038041
90sperm motility (GO:0030317)14.6318954
91cell wall macromolecule catabolic process (GO:0016998)13.7508417
92cell wall macromolecule metabolic process (GO:0044036)13.7508417
93fusion of sperm to egg plasma membrane (GO:0007342)13.0782103
94acrosome reaction (GO:0007340)12.5299868
95acrosome assembly (GO:0001675)11.8031224
96sperm-egg recognition (GO:0035036)11.5376380
97binding of sperm to zona pellucida (GO:0007339)10.6376387
98multicellular organism reproduction (GO:0032504)10.5704751
99cell-cell recognition (GO:0009988)10.3310130
100epithelial cilium movement (GO:0003351)10.0181836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.74465825
2EZH2_22144423_ChIP-Seq_EOC_Human4.00630268
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91080391
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34227666
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76332218
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76129563
7VDR_22108803_ChIP-Seq_LS180_Human2.54268490
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48170603
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31347593
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.20217492
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.13976693
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.12709793
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.10965988
14ZNF274_21170338_ChIP-Seq_K562_Hela1.98183253
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.93893424
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83107831
17MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.74172399
18STAT1_17558387_ChIP-Seq_HELA_Human1.72714502
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72534988
20TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70501920
21FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70281867
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.69365453
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65628412
24GATA3_21867929_ChIP-Seq_CD8_Mouse1.61878868
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56977903
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56788809
27KDM2B_26808549_Chip-Seq_REH_Human1.53465350
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.50223762
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48927066
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.45969136
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45438705
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.43117166
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42470632
34P53_21459846_ChIP-Seq_SAOS-2_Human1.41004799
35FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38331854
36REST_21632747_ChIP-Seq_MESCs_Mouse1.36048858
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35944934
38CBP_20019798_ChIP-Seq_JUKART_Human1.35944934
39LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34312820
40SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33402128
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31594329
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.29524268
43GF1_26923725_Chip-Seq_HPCs_Mouse1.28853720
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28669188
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25822373
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.25265994
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24927322
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23590168
49FLI1_21867929_ChIP-Seq_TH2_Mouse1.23541267
50CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23515436
51RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22909454
52CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18334019
53TAF15_26573619_Chip-Seq_HEK293_Human1.17031035
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15556336
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15556336
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14836295
57SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14492375
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13421386
59SPI1_26923725_Chip-Seq_HPCs_Mouse1.13208073
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13011134
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12702769
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12305345
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09991482
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.09416915
65ERG_20517297_ChIP-Seq_VCAP_Human1.08907679
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.08490481
67SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07729223
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07615172
69MYC_27129775_Chip-Seq_CORNEA_Mouse1.07481606
70ESET_19884257_ChIP-Seq_ESCs_Mouse1.07307203
71GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05585949
72JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05260305
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04882026
74RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04143452
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.03964681
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.02211161
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01739272
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00885696
79OCT4_18555785_Chip-Seq_ESCs_Mouse0.99032069
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98457973
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98006192
82RARA_24833708_ChIP-Seq_LIVER_Mouse0.97992265
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97636652
84P53_22387025_ChIP-Seq_ESCs_Mouse0.97522438
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96039914
86CMYC_18555785_Chip-Seq_ESCs_Mouse0.95979554
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94541905
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94526125
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94000491
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93638896
91LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92569623
92CTCF_20526341_ChIP-Seq_ESCs_Human0.92512580
93NANOG_20526341_ChIP-Seq_ESCs_Human0.92385252
94FLI1_21867929_ChIP-Seq_CD8_Mouse0.92039918
95SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92035382
96NFYB_21822215_ChIP-Seq_K562_Human0.91764988
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90643577
98SOX9_26525672_Chip-Seq_HEART_Mouse0.90512768
99RNF2_27304074_Chip-Seq_NSC_Mouse0.90262451
100SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90148079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.13023574
2MP0001929_abnormal_gametogenesis5.61049143
3MP0008877_abnormal_DNA_methylation3.73025187
4MP0002161_abnormal_fertility/fecundity3.34545607
5MP0002210_abnormal_sex_determination3.29310766
6MP0005670_abnormal_white_adipose2.93712159
7MP0001145_abnormal_male_reproductive2.78263806
8MP0000653_abnormal_sex_gland2.40171831
9MP0005410_abnormal_fertilization16.9024120
10MP0002653_abnormal_ependyma_morphology1.65420078
11MP0002160_abnormal_reproductive_system1.37361631
12MP0004233_abnormal_muscle_weight1.32687462
13MP0001765_abnormal_ion_homeostasis1.22672766
14MP0003646_muscle_fatigue1.20626612
15MP0005623_abnormal_meninges_morphology1.10565062
16MP0002282_abnormal_trachea_morphology1.00213055
17MP0003011_delayed_dark_adaptation0.99681111
18MP0002234_abnormal_pharynx_morphology0.99347855
19MP0001984_abnormal_olfaction0.91419840
20MP0005647_abnormal_sex_gland0.80189508
21MP0008058_abnormal_DNA_repair0.77267732
22MP0005636_abnormal_mineral_homeostasis0.70260824
23MP0009046_muscle_twitch0.67180045
24MP0005389_reproductive_system_phenotype0.64809712
25MP0003115_abnormal_respiratory_system0.64649042
26MP0003329_amyloid_beta_deposits0.63529375
27MP0002736_abnormal_nociception_after0.60856901
28MP0004036_abnormal_muscle_relaxation0.58453661
29MP0008995_early_reproductive_senescence0.58302913
30MP0005666_abnormal_adipose_tissue0.56845838
31MP0001764_abnormal_homeostasis0.53570649
32MP0001324_abnormal_eye_pigmentation0.53541190
33MP0003950_abnormal_plasma_membrane0.49062533
34MP0005377_hearing/vestibular/ear_phenot0.48151618
35MP0003878_abnormal_ear_physiology0.48151618
36MP0005551_abnormal_eye_electrophysiolog0.44272609
37MP0002269_muscular_atrophy0.43878625
38MP0005253_abnormal_eye_physiology0.43560435
39MP0003699_abnormal_female_reproductive0.41862663
40MP0000358_abnormal_cell_content/0.41463791
41MP0006036_abnormal_mitochondrial_physio0.40673750
42MP0001293_anophthalmia0.38017847
43MP0002139_abnormal_hepatobiliary_system0.37436945
44MP0002102_abnormal_ear_morphology0.35383075
45MP0000569_abnormal_digit_pigmentation0.34901107
46MP0004133_heterotaxia0.34626417
47MP0001968_abnormal_touch/_nociception0.34373718
48MP0004270_analgesia0.34304728
49MP0003633_abnormal_nervous_system0.33640668
50MP0004145_abnormal_muscle_electrophysio0.33262162
51MP0000604_amyloidosis0.32812422
52MP0000534_abnormal_ureter_morphology0.32385337
53MP0003879_abnormal_hair_cell0.31369307
54MP0009115_abnormal_fat_cell0.31298708
55MP0004742_abnormal_vestibular_system0.31182506
56MP0002971_abnormal_brown_adipose0.30990638
57MP0008875_abnormal_xenobiotic_pharmacok0.30704170
58MP0005391_vision/eye_phenotype0.30554915
59MP0005397_hematopoietic_system_phenotyp0.30483243
60MP0001545_abnormal_hematopoietic_system0.30483243
61MP0004019_abnormal_vitamin_homeostasis0.28207771
62MP0001727_abnormal_embryo_implantation0.27425158
63MP0000920_abnormal_myelination0.26608196
64MP0004811_abnormal_neuron_physiology0.26398609
65MP0002169_no_abnormal_phenotype0.24707963
66MP0002873_normal_phenotype0.24604788
67MP0003111_abnormal_nucleus_morphology0.24359344
68MP0010094_abnormal_chromosome_stability0.24150229
69MP0003631_nervous_system_phenotype0.23996715
70MP0003861_abnormal_nervous_system0.23656386
71MP0002928_abnormal_bile_duct0.22989818
72MP0001730_embryonic_growth_arrest0.22920977
73MP0000462_abnormal_digestive_system0.22050146
74MP0006072_abnormal_retinal_apoptosis0.21938436
75MP0001661_extended_life_span0.21861865
76MP0002152_abnormal_brain_morphology0.21679434
77MP0003948_abnormal_gas_homeostasis0.20658494
78MP0003942_abnormal_urinary_system0.20348049
79MP0008569_lethality_at_weaning0.19680368
80MP0009278_abnormal_bone_marrow0.19253882
81MP0001119_abnormal_female_reproductive0.18786534
82MP0006035_abnormal_mitochondrial_morpho0.18779611
83MP0005365_abnormal_bile_salt0.18663266
84MP0004043_abnormal_pH_regulation0.17961610
85MP0005319_abnormal_enzyme/_coenzyme0.17407300
86MP0003806_abnormal_nucleotide_metabolis0.16565158
87MP0004084_abnormal_cardiac_muscle0.16341414
88MP0005375_adipose_tissue_phenotype0.16229952
89MP0002909_abnormal_adrenal_gland0.15973215
90MP0002229_neurodegeneration0.15826306
91MP0002693_abnormal_pancreas_physiology0.15682178
92MP0002118_abnormal_lipid_homeostasis0.15319172
93MP0001849_ear_inflammation0.15280273
94MP0000001_mammalian_phenotype0.14823078
95MP0002295_abnormal_pulmonary_circulatio0.14098028
96MP0002092_abnormal_eye_morphology0.13706182
97MP0001348_abnormal_lacrimal_gland0.13487095
98MP0005195_abnormal_posterior_eye0.12852425
99MP0002132_abnormal_respiratory_system0.11435842
100MP0002272_abnormal_nervous_system0.10426555

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.83027242
2Abnormal respiratory motile cilium morphology (HP:0005938)9.53168449
3Abnormal respiratory epithelium morphology (HP:0012253)9.53168449
4Chronic bronchitis (HP:0004469)7.80844867
5Abnormal ciliary motility (HP:0012262)7.75848081
6Rhinitis (HP:0012384)7.43873242
7Infertility (HP:0000789)7.01673942
8Nasal polyposis (HP:0100582)6.12377397
9Abnormality of the nasal mucosa (HP:0000433)5.02743899
10Male infertility (HP:0003251)4.95280059
11Bronchitis (HP:0012387)4.53975924
12Bronchiectasis (HP:0002110)4.37367323
13Abnormal spermatogenesis (HP:0008669)3.71408898
14Nephronophthisis (HP:0000090)3.63621859
15Recurrent sinusitis (HP:0011108)3.36805734
16Recurrent otitis media (HP:0000403)3.24163047
17Abnormality of the renal medulla (HP:0100957)2.72791212
18Tubulointerstitial nephritis (HP:0001970)2.72452889
19Molar tooth sign on MRI (HP:0002419)2.46443368
20Abnormality of midbrain morphology (HP:0002418)2.46443368
21Recurrent bronchitis (HP:0002837)2.36063296
22Azoospermia (HP:0000027)2.34935327
23Impulsivity (HP:0100710)2.34576784
24Tubular atrophy (HP:0000092)2.28448984
25Cholecystitis (HP:0001082)2.27980239
26Abnormal gallbladder physiology (HP:0012438)2.27980239
27Tubulointerstitial abnormality (HP:0001969)2.23280602
28Medial flaring of the eyebrow (HP:0010747)2.16258110
29Dyschromatopsia (HP:0007641)2.13468115
30Gonadotropin excess (HP:0000837)2.05356579
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.9495929
32Absent/shortened dynein arms (HP:0200106)13.9495929
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2716010
34Decreased central vision (HP:0007663)1.94680776
35Double outlet right ventricle (HP:0001719)1.89661381
36Congenital malformation of the right heart (HP:0011723)1.89661381
37Spastic tetraparesis (HP:0001285)1.88550189
38Hemorrhage of the eye (HP:0011885)1.78291033
39Choroideremia (HP:0001139)1.77856632
40Tubulointerstitial fibrosis (HP:0005576)1.72916295
41Neurofibrillary tangles (HP:0002185)1.67484430
42Asymmetric septal hypertrophy (HP:0001670)1.58655487
43Stage 5 chronic kidney disease (HP:0003774)1.57630896
44Postaxial foot polydactyly (HP:0001830)1.55419366
45Abnormality of renal excretion (HP:0011036)1.54389781
46Abnormal drinking behavior (HP:0030082)1.53990369
47Polydipsia (HP:0001959)1.53990369
48Bundle branch block (HP:0011710)1.52365575
49Decreased electroretinogram (ERG) amplitude (HP:0000654)1.49484951
50Heterotopia (HP:0002282)1.48243874
51Abnormality of the dental root (HP:0006486)1.47470771
52Taurodontia (HP:0000679)1.47470771
53Abnormality of permanent molar morphology (HP:0011071)1.47470771
54Hypoplasia of the capital femoral epiphysis (HP:0003090)1.46645673
55Exercise-induced myalgia (HP:0003738)1.46403481
56Congenital hepatic fibrosis (HP:0002612)1.44379203
57Abnormality of the renal cortex (HP:0011035)1.43506379
58Chronic sinusitis (HP:0011109)1.42731873
59Abnormal biliary tract physiology (HP:0012439)1.41765868
60Bile duct proliferation (HP:0001408)1.41765868
61Aplasia/Hypoplasia of the lens (HP:0008063)1.41728015
62Abnormality of the dental pulp (HP:0006479)1.38586287
63Sensory axonal neuropathy (HP:0003390)1.37974368
64Oculomotor apraxia (HP:0000657)1.37376852
65Easy fatigability (HP:0003388)1.37108025
66Abnormality of molar (HP:0011077)1.36517467
67Abnormality of molar morphology (HP:0011070)1.36517467
68Constricted visual fields (HP:0001133)1.35608137
69Cerebral inclusion bodies (HP:0100314)1.35540934
70Bell-shaped thorax (HP:0001591)1.33584474
71Cystic liver disease (HP:0006706)1.32460112
72Abnormality of dentin (HP:0010299)1.32318712
73Fibular hypoplasia (HP:0003038)1.31973455
74Short ribs (HP:0000773)1.30754894
75Hypercholesterolemia (HP:0003124)1.29609044
76Myoglobinuria (HP:0002913)1.25640463
77Postaxial hand polydactyly (HP:0001162)1.25577529
78Abnormal urine output (HP:0012590)1.25223814
79Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.24914212
80Hyperkalemia (HP:0002153)1.23755453
81Broad distal phalanx of finger (HP:0009836)1.23361948
82Supernumerary spleens (HP:0009799)1.23011182
83Fatigable weakness (HP:0003473)1.22137149
84Abnormality of the neuromuscular junction (HP:0003398)1.22137149
85Renal dysplasia (HP:0000110)1.20579612
86Hemiparesis (HP:0001269)1.15583759
87Neoplasm of the heart (HP:0100544)1.15117251
88Facial cleft (HP:0002006)1.14824553
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.14117552
90Absent epiphyses (HP:0010577)1.14117552
91Pancreatic fibrosis (HP:0100732)1.13788785
92Deformed sella turcica (HP:0002681)1.13466453
93Rhabdomyolysis (HP:0003201)1.12424756
94Peripheral hypomyelination (HP:0007182)1.12150796
95Gait imbalance (HP:0002141)1.10958440
96Retinal dysplasia (HP:0007973)1.09454834
97Congenital primary aphakia (HP:0007707)1.09253759
98Vascular calcification (HP:0004934)1.09180516
99Exercise-induced muscle cramps (HP:0003710)1.07166829
100Abnormal connection of the cardiac segments (HP:0011545)1.06490342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.50841374
2PDK48.50841374
3TESK15.92844247
4PDK25.59253853
5PRKD34.55254526
6ICK4.29188411
7STK392.06535246
8PTK2B2.05513633
9WNK42.03623659
10STK381.67670323
11DYRK1B1.66388362
12PNCK1.64352565
13NEK21.35213366
14PDK11.26615212
15IRAK11.13547852
16MAPK151.04847820
17DYRK30.95512706
18TYRO30.83179518
19PDPK10.83066483
20IRAK20.82875823
21WNK10.78174289
22RIPK40.76530176
23CCNB10.71128374
24PASK0.66432270
25CHEK20.57055607
26MUSK0.56202584
27PINK10.56146987
28EEF2K0.55900809
29MAP2K60.53382953
30STK30.52723851
31NEK60.51311449
32TTK0.49733991
33TESK20.47120340
34LMTK20.46035012
35NTRK20.42855414
36MAPKAPK50.41355085
37PRKCG0.38929208
38PAK10.37166579
39BRD40.36296888
40STK38L0.33425531
41CAMK1G0.33150515
42CHEK10.32977406
43MAP3K100.29852797
44MARK20.25578226
45PAK20.25244729
46CDK150.22276386
47PRKCZ0.22209901
48MTOR0.20455345
49PRKCQ0.20404940
50CDK11A0.19235505
51CDK180.19141684
52ATM0.19073905
53PRKG20.18642105
54CAMKK10.17523484
55PKN10.16419696
56WEE10.15805294
57CDK140.14998596
58PRKAA10.13785779
59PAK40.13101504
60BRSK20.12760993
61PLK10.11417931
62RPS6KB10.10078028
63ATR0.10076016
64MAP3K10.07934800
65CDK60.07207359
66STK100.07097767
67PLK40.06662115
68CSNK2A10.06433412
69PRKG10.06350732
70BRSK10.06305555
71WNK30.05888160
72GSK3B0.05786256
73PRKCD0.05096704
74RPS6KA10.03978493
75PRKACG0.03246423
76CLK10.03050576
77CAMK2A0.03002404
78PRKCB0.02813406
79PRKCA0.01568422
80BMPR1B0.01469996
81CDK20.01290008
82MAPK80.01238419
83STK110.01201375
84CDK10.01002983
85PRKACB0.00976627
86MARK30.00258646
87CSNK2A20.00215129
88CSNK1D0.00028607
89PRKACA-0.0255248
90RPS6KA3-0.0242721
91EGFR-0.0231750
92MAP4K1-0.0224797
93CDK4-0.0169799
94PIM1-0.0155334
95CDC7-0.0126182
96MARK1-0.0117247
97AURKA-0.0113676
98BRAF-0.0095388
99CSF1R-0.0051715
100MAP2K7-0.0006811

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.66872245
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.56208281
3Vitamin B6 metabolism_Homo sapiens_hsa007504.03813619
4Pyruvate metabolism_Homo sapiens_hsa006203.38335068
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.15217145
6Linoleic acid metabolism_Homo sapiens_hsa005913.10568598
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.92209278
8Propanoate metabolism_Homo sapiens_hsa006402.56674234
9Glucagon signaling pathway_Homo sapiens_hsa049222.50503742
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.34695673
11Basal transcription factors_Homo sapiens_hsa030222.11073347
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03757095
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03655284
14Selenocompound metabolism_Homo sapiens_hsa004501.99223271
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.98627116
16Glycerolipid metabolism_Homo sapiens_hsa005611.96189252
17PPAR signaling pathway_Homo sapiens_hsa033201.81579193
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.68436245
19Mineral absorption_Homo sapiens_hsa049781.64906359
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.58878722
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.56066484
22Fat digestion and absorption_Homo sapiens_hsa049751.54449522
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53725780
24Oocyte meiosis_Homo sapiens_hsa041141.52584412
25Amphetamine addiction_Homo sapiens_hsa050311.52269850
26Ether lipid metabolism_Homo sapiens_hsa005651.50987544
27Fatty acid degradation_Homo sapiens_hsa000711.47494002
28Fructose and mannose metabolism_Homo sapiens_hsa000511.46449196
29Pentose phosphate pathway_Homo sapiens_hsa000301.44057569
30Fatty acid metabolism_Homo sapiens_hsa012121.43583232
31Carbon metabolism_Homo sapiens_hsa012001.33546760
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29131445
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26530732
34Dorso-ventral axis formation_Homo sapiens_hsa043201.25513941
35Cardiac muscle contraction_Homo sapiens_hsa042601.24739952
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15403127
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.12743414
38Renin secretion_Homo sapiens_hsa049241.11804374
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07888109
40Purine metabolism_Homo sapiens_hsa002301.07780236
41Collecting duct acid secretion_Homo sapiens_hsa049661.04710320
42Glutathione metabolism_Homo sapiens_hsa004801.02679905
43Antigen processing and presentation_Homo sapiens_hsa046120.96861556
44Hedgehog signaling pathway_Homo sapiens_hsa043400.96381400
45Biosynthesis of amino acids_Homo sapiens_hsa012300.90704118
46Chemical carcinogenesis_Homo sapiens_hsa052040.90539104
47Insulin secretion_Homo sapiens_hsa049110.86397172
48Arachidonic acid metabolism_Homo sapiens_hsa005900.85708840
49Bile secretion_Homo sapiens_hsa049760.82308896
50Fanconi anemia pathway_Homo sapiens_hsa034600.80769997
51Thyroid hormone synthesis_Homo sapiens_hsa049180.78478284
52mRNA surveillance pathway_Homo sapiens_hsa030150.75550842
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.74543612
54Estrogen signaling pathway_Homo sapiens_hsa049150.72685374
55Huntingtons disease_Homo sapiens_hsa050160.70784280
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69579038
57Long-term potentiation_Homo sapiens_hsa047200.65334993
58Pancreatic secretion_Homo sapiens_hsa049720.64664190
59Salivary secretion_Homo sapiens_hsa049700.60894448
60Sulfur metabolism_Homo sapiens_hsa009200.60165925
61RNA transport_Homo sapiens_hsa030130.57228318
62Legionellosis_Homo sapiens_hsa051340.55411241
63Protein digestion and absorption_Homo sapiens_hsa049740.51515699
64Synaptic vesicle cycle_Homo sapiens_hsa047210.50362569
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50359467
66Calcium signaling pathway_Homo sapiens_hsa040200.50077421
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48251831
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48074135
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.46456199
70Renin-angiotensin system_Homo sapiens_hsa046140.44745643
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.44542677
72Gastric acid secretion_Homo sapiens_hsa049710.44494799
73Systemic lupus erythematosus_Homo sapiens_hsa053220.43901354
74ABC transporters_Homo sapiens_hsa020100.43769759
75Endocytosis_Homo sapiens_hsa041440.42671438
76Metabolic pathways_Homo sapiens_hsa011000.41148785
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40902383
78Inositol phosphate metabolism_Homo sapiens_hsa005620.39677730
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39042487
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35950143
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35361192
82cAMP signaling pathway_Homo sapiens_hsa040240.31737579
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31404156
84Pyrimidine metabolism_Homo sapiens_hsa002400.31066427
85AMPK signaling pathway_Homo sapiens_hsa041520.30998274
86Cocaine addiction_Homo sapiens_hsa050300.28050199
87VEGF signaling pathway_Homo sapiens_hsa043700.26708411
88Circadian entrainment_Homo sapiens_hsa047130.24714939
89Taste transduction_Homo sapiens_hsa047420.22891225
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21967628
91Alcoholism_Homo sapiens_hsa050340.19397278
92Retinol metabolism_Homo sapiens_hsa008300.16704910
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.16569372
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12267025
95Salmonella infection_Homo sapiens_hsa051320.11605321
96Wnt signaling pathway_Homo sapiens_hsa043100.10937908
97B cell receptor signaling pathway_Homo sapiens_hsa046620.10073804
98Sulfur relay system_Homo sapiens_hsa041220.08674978
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08104048
100Glutamatergic synapse_Homo sapiens_hsa047240.06015968

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