HYOU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.87138608
2Golgi transport vesicle coating (GO:0048200)8.87138608
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.63233921
4* activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.10785049
5* positive regulation of nuclease activity (GO:0032075)5.85645588
6COPII vesicle coating (GO:0048208)5.63309277
7protein retention in ER lumen (GO:0006621)5.42066887
8* regulation of nuclease activity (GO:0032069)5.32224464
9* endoplasmic reticulum unfolded protein response (GO:0030968)5.23838893
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.18088441
11* cellular response to unfolded protein (GO:0034620)5.06439414
12nuclear pore complex assembly (GO:0051292)5.06266260
13* ER-nucleus signaling pathway (GO:0006984)4.92380826
14* cellular response to topologically incorrect protein (GO:0035967)4.72228630
15L-alpha-amino acid transmembrane transport (GO:1902475)4.63507843
164-hydroxyproline metabolic process (GO:0019471)4.59737344
17exocrine pancreas development (GO:0031017)4.53244859
18ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.52874038
19protein maturation by protein folding (GO:0022417)4.51333513
20endocrine pancreas development (GO:0031018)4.46200589
21vesicle coating (GO:0006901)4.38495650
22sequestering of metal ion (GO:0051238)4.35303802
23regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.28974872
24* response to endoplasmic reticulum stress (GO:0034976)4.23508942
25proline biosynthetic process (GO:0006561)4.18115519
26type B pancreatic cell development (GO:0003323)4.16386271
27DNA unwinding involved in DNA replication (GO:0006268)4.14430113
28nuclear pore organization (GO:0006999)4.06180363
29glandular epithelial cell development (GO:0002068)3.95949662
30intestinal cholesterol absorption (GO:0030299)3.95105814
31macroautophagy (GO:0016236)3.94834922
32hemidesmosome assembly (GO:0031581)3.88997506
33* response to unfolded protein (GO:0006986)3.85948814
34mitotic chromosome condensation (GO:0007076)3.76479408
35peptide hormone processing (GO:0016486)3.67267020
36* response to topologically incorrect protein (GO:0035966)3.66852277
37glandular epithelial cell differentiation (GO:0002067)3.66814012
38peptidyl-asparagine modification (GO:0018196)3.66622395
39positive regulation of histone deacetylation (GO:0031065)3.65160888
40protein N-linked glycosylation via asparagine (GO:0018279)3.64940933
41pore complex assembly (GO:0046931)3.63443907
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60887658
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.60865432
44protein localization to endosome (GO:0036010)3.57628405
45regulation of cholesterol homeostasis (GO:2000188)3.57088182
46columnar/cuboidal epithelial cell development (GO:0002066)3.50677362
47adherens junction assembly (GO:0034333)3.40177061
48intestinal absorption (GO:0050892)3.38022671
49UDP-N-acetylglucosamine metabolic process (GO:0006047)3.36599300
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34164328
51chromosome condensation (GO:0030261)3.33436655
52folic acid-containing compound biosynthetic process (GO:0009396)3.32951320
53regulation of RNA export from nucleus (GO:0046831)3.30543760
54cell-substrate junction assembly (GO:0007044)3.30320658
55protein N-linked glycosylation (GO:0006487)3.29901390
56cerebellar Purkinje cell layer development (GO:0021680)3.27958070
57cell-substrate adherens junction assembly (GO:0007045)3.26327295
58focal adhesion assembly (GO:0048041)3.26327295
59ER overload response (GO:0006983)3.24787599
60protein complex localization (GO:0031503)3.23822563
61Golgi organization (GO:0007030)3.23422982
62regulation of nucleobase-containing compound transport (GO:0032239)3.17300555
63epithelial cell-cell adhesion (GO:0090136)3.16539924
64activation of Rac GTPase activity (GO:0032863)3.10215728
65L-phenylalanine catabolic process (GO:0006559)3.08756966
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08756966
67desmosome organization (GO:0002934)3.08374672
68peptidyl-proline hydroxylation (GO:0019511)3.07502286
69basement membrane organization (GO:0071711)3.07265907
70glucose 6-phosphate metabolic process (GO:0051156)3.07100658
71spliceosomal tri-snRNP complex assembly (GO:0000244)3.04804288
72regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04338707
73intestinal epithelial cell development (GO:0060576)3.04221578
74skin morphogenesis (GO:0043589)3.01591774
75heterochromatin organization (GO:0070828)3.00999192
76cellular response to vitamin D (GO:0071305)3.00979460
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.99008964
78L-phenylalanine metabolic process (GO:0006558)2.99008964
79apoptotic cell clearance (GO:0043277)2.98394187
80protein export from nucleus (GO:0006611)2.98114715
81proline metabolic process (GO:0006560)2.96977394
82cell adhesion mediated by integrin (GO:0033627)2.95602208
83paraxial mesoderm development (GO:0048339)2.90553318
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.90366418
85cellular protein complex localization (GO:0034629)2.89765958
86protein autoprocessing (GO:0016540)2.89339093
87protein-DNA complex disassembly (GO:0032986)2.88202678
88nucleosome disassembly (GO:0006337)2.88202678
89mannose metabolic process (GO:0006013)2.88161300
90hormone catabolic process (GO:0042447)2.87417641
91protein localization to microtubule (GO:0035372)2.86580231
92positive regulation of hormone biosynthetic process (GO:0046886)2.86506782
93maternal placenta development (GO:0001893)2.86120504
94establishment of apical/basal cell polarity (GO:0035089)2.85711605
95sulfur amino acid catabolic process (GO:0000098)2.84713581
96negative regulation of cell size (GO:0045792)2.82397885
97regulation of histone H3-K27 methylation (GO:0061085)2.82107224
98insulin-like growth factor receptor signaling pathway (GO:0048009)2.81679896
99regulation of early endosome to late endosome transport (GO:2000641)2.79256274
100urea cycle (GO:0000050)2.78101162
101urea metabolic process (GO:0019627)2.78101162
102DNA packaging (GO:0006323)2.77441601
103semaphorin-plexin signaling pathway (GO:0071526)2.77344618
104positive regulation of insulin secretion (GO:0032024)2.76698504
105negative regulation of fibrinolysis (GO:0051918)2.75861290
106protein carboxylation (GO:0018214)2.75663864
107peptidyl-glutamic acid carboxylation (GO:0017187)2.75663864
108negative regulation of histone methylation (GO:0031061)2.74941798
109positive regulation of glycolytic process (GO:0045821)2.74558175
110regulation of NFAT protein import into nucleus (GO:0051532)2.72847392
111protein hydroxylation (GO:0018126)2.72487515
112cellular modified amino acid catabolic process (GO:0042219)2.71363087
113peptidyl-lysine dimethylation (GO:0018027)2.68339644
114cellular copper ion homeostasis (GO:0006878)2.67472372
115regulation of translational fidelity (GO:0006450)2.67336680
116positive regulation of hormone metabolic process (GO:0032352)2.66783704
117branching involved in mammary gland duct morphogenesis (GO:0060444)2.65571363
118apoptotic process involved in morphogenesis (GO:0060561)2.64879136
119alpha-linolenic acid metabolic process (GO:0036109)2.63222317
120membrane protein ectodomain proteolysis (GO:0006509)2.61434173
121regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61177895
122protein targeting to Golgi (GO:0000042)2.60726154
123intra-Golgi vesicle-mediated transport (GO:0006891)2.60311556
124mRNA stabilization (GO:0048255)2.59993923
125RNA stabilization (GO:0043489)2.59993923
126cellular response to epidermal growth factor stimulus (GO:0071364)2.58696681
127tricarboxylic acid metabolic process (GO:0072350)2.58328290
128peptidyl-arginine omega-N-methylation (GO:0035247)2.58090392
129regulation of fatty acid beta-oxidation (GO:0031998)2.55545610
130negative regulation of lipid transport (GO:0032369)2.55543549
131valine metabolic process (GO:0006573)2.54191500
132L-serine metabolic process (GO:0006563)2.53173553
133reverse cholesterol transport (GO:0043691)2.52802417
134positive regulation of triglyceride biosynthetic process (GO:0010867)2.52580243
135gap junction assembly (GO:0016264)2.52260705
136establishment of protein localization to Golgi (GO:0072600)2.51955621
137pentose-phosphate shunt (GO:0006098)2.51791868
138insulin secretion (GO:0030073)2.51198798
139regulation of polysaccharide biosynthetic process (GO:0032885)2.51081940
140convergent extension (GO:0060026)2.50900817
141complement activation, alternative pathway (GO:0006957)2.50548028
142bundle of His cell to Purkinje myocyte communication (GO:0086069)2.49381594
143regulation of translational termination (GO:0006449)2.48628150
144histone H3-K36 demethylation (GO:0070544)2.47063618
145corticosteroid receptor signaling pathway (GO:0031958)2.46683294
146low-density lipoprotein particle clearance (GO:0034383)2.46601279
147positive regulation of glycogen biosynthetic process (GO:0045725)2.46519627
148positive regulation of p38MAPK cascade (GO:1900745)2.46450171
149notochord development (GO:0030903)2.46393404
150ER to Golgi vesicle-mediated transport (GO:0006888)2.46195338
151high-density lipoprotein particle remodeling (GO:0034375)2.45855324
152endoplasmic reticulum organization (GO:0007029)2.45485686
153mitotic sister chromatid cohesion (GO:0007064)2.45400501
154dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44269834
155glucocorticoid receptor signaling pathway (GO:0042921)2.43916009
156embryonic process involved in female pregnancy (GO:0060136)2.43782117
157mitotic sister chromatid segregation (GO:0000070)2.42762032
158protein localization to chromosome, centromeric region (GO:0071459)2.42712318
159positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42337991
160intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.42255036
161tetrahydrofolate metabolic process (GO:0046653)2.41322164
162nitrogen cycle metabolic process (GO:0071941)2.40429955
163response to hexose (GO:0009746)2.40057428
164homocysteine metabolic process (GO:0050667)2.39074041
165cellular zinc ion homeostasis (GO:0006882)2.37428643
166maintenance of protein localization in organelle (GO:0072595)2.37312002
167response to glucose (GO:0009749)2.37250314
168negative regulation of glycogen biosynthetic process (GO:0045719)2.37135253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.65858799
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.13337770
3E2F7_22180533_ChIP-Seq_HELA_Human5.09062213
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.89841968
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.63764146
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.37370165
7GATA1_22025678_ChIP-Seq_K562_Human3.21181328
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07013060
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.87583575
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.81768815
11CLOCK_20551151_ChIP-Seq_293T_Human2.58591264
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54485346
13MYC_22102868_ChIP-Seq_BL_Human2.48257439
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40023256
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27487655
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26515027
17AR_21909140_ChIP-Seq_LNCAP_Human2.15073418
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14040735
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13860681
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13114458
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.10854758
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.09716510
23SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06351253
24ZNF263_19887448_ChIP-Seq_K562_Human1.85209468
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79704821
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77498293
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77297040
28TCF7_22412390_ChIP-Seq_EML_Mouse1.71932621
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71400662
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67871528
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67317278
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64213750
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63629497
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.63238386
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63169754
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.62862570
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.61766238
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61416509
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61184015
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60638874
41FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.59403560
42* LXR_22292898_ChIP-Seq_THP-1_Human1.55195181
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55177318
44GATA6_25053715_ChIP-Seq_YYC3_Human1.55064391
45RACK7_27058665_Chip-Seq_MCF-7_Human1.54868405
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54266692
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53008335
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52992644
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52788549
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50473806
51KDM2B_26808549_Chip-Seq_DND41_Human1.49084065
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48800415
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47996754
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47669346
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44950356
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43299814
57CREB1_26743006_Chip-Seq_LNCaP_Human1.42939037
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.42770342
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42048769
60ATF3_27146783_Chip-Seq_COLON_Human1.39400322
61* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39308002
62* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38622147
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36866470
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33671573
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33662946
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33540651
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33286096
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32926849
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.32796256
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31169243
71NCOR1_26117541_ChIP-Seq_K562_Human1.31058846
72CHD1_26751641_Chip-Seq_LNCaP_Human1.28782629
73* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28177618
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28049581
75* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27815967
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27739308
77XRN2_22483619_ChIP-Seq_HELA_Human1.27177673
78KDM2B_26808549_Chip-Seq_K562_Human1.25774693
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25241894
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24891281
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21912844
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21445700
83VDR_21846776_ChIP-Seq_THP-1_Human1.21333081
84* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21268450
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19902439
86* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19855615
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.19823115
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19339822
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18498835
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.18447412
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.17844883
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17718447
93UTX_26944678_Chip-Seq_JUKART_Human1.17671156
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17125328
95* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16540194
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15737654
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15400527
98GATA1_19941826_ChIP-Seq_K562_Human1.14373830
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14280455
100FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.12760421
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11403537
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11267390
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10997085
104TP53_22127205_ChIP-Seq_IMR90_Human1.10717216
105* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10531102
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07957925
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07723557
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07405357
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05248327
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04289585
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03833539
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.03053248
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.02479196
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.02275068
115TFEB_21752829_ChIP-Seq_HELA_Human1.02072553
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01433297
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01213553
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01160221
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00946612
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00518919
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.00375844
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99828969
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99578626
124HNF4A_19822575_ChIP-Seq_HepG2_Human0.99474003
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99047877
126SMC4_20622854_ChIP-Seq_HELA_Human0.98899622
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97579646
128TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97574919
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97559496
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97243691
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96887215
132GATA4_25053715_ChIP-Seq_YYC3_Human0.96726636
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95268905
134* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94667269
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93441910
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.93258673
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.93258673
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90907758
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89374825
140* GATA3_24758297_ChIP-Seq_MCF-7_Human0.89331087
141HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89079942
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86141318
143* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84988860
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84044311
145KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83323512
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.83194615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.20124454
2MP0003283_abnormal_digestive_organ4.16740823
3MP0002139_abnormal_hepatobiliary_system3.82149288
4MP0005365_abnormal_bile_salt3.21292229
5MP0003300_gastrointestinal_ulcer3.18040576
6MP0003252_abnormal_bile_duct3.09397518
7MP0009780_abnormal_chondrocyte_physiolo3.00662199
8MP0001944_abnormal_pancreas_morphology2.96754742
9MP0002693_abnormal_pancreas_physiology2.94966536
10MP0002909_abnormal_adrenal_gland2.88806733
11MP0003195_calcinosis2.80298786
12MP0003705_abnormal_hypodermis_morpholog2.73338033
13MP0005451_abnormal_body_composition2.63240192
14MP0005220_abnormal_exocrine_pancreas2.61920938
15MP0004233_abnormal_muscle_weight2.57262882
16MP0005085_abnormal_gallbladder_physiolo2.55477016
17MP0004264_abnormal_extraembryonic_tissu2.47730419
18MP0010234_abnormal_vibrissa_follicle2.42859949
19MP0005360_urolithiasis2.34682898
20MP0005076_abnormal_cell_differentiation2.30018203
21MP0003693_abnormal_embryo_hatching2.25552937
22MP0004043_abnormal_pH_regulation2.17769754
23MP0004957_abnormal_blastocyst_morpholog2.17674088
24MP0003868_abnormal_feces_composition2.16034327
25MP0004858_abnormal_nervous_system2.07216912
26MP0005623_abnormal_meninges_morphology2.05492758
27MP0001730_embryonic_growth_arrest2.05224709
28MP0000678_abnormal_parathyroid_gland2.04875262
29MP0003111_abnormal_nucleus_morphology1.99954800
30MP0001666_abnormal_nutrient_absorption1.94081578
31MP0005083_abnormal_biliary_tract1.92002021
32MP0010352_gastrointestinal_tract_polyps1.88280442
33MP0003941_abnormal_skin_development1.87966215
34MP0000566_synostosis1.82124841
35MP0002078_abnormal_glucose_homeostasis1.80835487
36MP0005409_darkened_coat_color1.79156716
37MP0002928_abnormal_bile_duct1.74897882
38MP0002796_impaired_skin_barrier1.73320581
39MP0009840_abnormal_foam_cell1.70308853
40MP0008961_abnormal_basal_metabolism1.69755518
41MP0002896_abnormal_bone_mineralization1.68555016
42MP0002089_abnormal_postnatal_growth/wei1.66219631
43MP0000579_abnormal_nail_morphology1.64105544
44MP0001348_abnormal_lacrimal_gland1.60598487
45MP0000013_abnormal_adipose_tissue1.59116684
46MP0003566_abnormal_cell_adhesion1.56798652
47MP0003453_abnormal_keratinocyte_physiol1.56792779
48MP0005380_embryogenesis_phenotype1.53780873
49MP0001672_abnormal_embryogenesis/_devel1.53780873
50MP0006054_spinal_hemorrhage1.52045708
51MP0003045_fibrosis1.51958881
52MP0010329_abnormal_lipoprotein_level1.50785454
53MP0003091_abnormal_cell_migration1.50029816
54MP0008932_abnormal_embryonic_tissue1.49442991
55MP0003984_embryonic_growth_retardation1.48258292
56MP0003183_abnormal_peptide_metabolism1.47656471
57MP0009643_abnormal_urine_homeostasis1.43895598
58MP0003077_abnormal_cell_cycle1.41960809
59MP0000609_abnormal_liver_physiology1.40804724
60MP0002060_abnormal_skin_morphology1.40400851
61MP0002088_abnormal_embryonic_growth/wei1.40195736
62MP0000350_abnormal_cell_proliferation1.39956032
63MP0005501_abnormal_skin_physiology1.39911257
64* MP0002080_prenatal_lethality1.39415891
65MP0003303_peritoneal_inflammation1.37548268
66MP0004782_abnormal_surfactant_physiolog1.37381795
67MP0000003_abnormal_adipose_tissue1.35054585
68MP0001915_intracranial_hemorrhage1.29284732
69MP0010030_abnormal_orbit_morphology1.28635947
70MP0000613_abnormal_salivary_gland1.26830501
71MP0002234_abnormal_pharynx_morphology1.26820310
72MP0009672_abnormal_birth_weight1.25837186
73MP0003172_abnormal_lysosome_physiology1.25109429
74MP0002085_abnormal_embryonic_tissue1.24988713
75MP0001765_abnormal_ion_homeostasis1.21383825
76MP0005187_abnormal_penis_morphology1.20533915
77MP0003329_amyloid_beta_deposits1.20273207
78MP0001697_abnormal_embryo_size1.19633392
79MP0010094_abnormal_chromosome_stability1.19473813
80MP0000467_abnormal_esophagus_morphology1.16515328
81MP0003385_abnormal_body_wall1.13498077
82MP0002254_reproductive_system_inflammat1.13089408
83MP0002138_abnormal_hepatobiliary_system1.12419985
84MP0005621_abnormal_cell_physiology1.12049967
85MP0005058_abnormal_lysosome_morphology1.10558240
86MP0001216_abnormal_epidermal_layer1.09037341
87MP0000762_abnormal_tongue_morphology1.08145696
88MP0005257_abnormal_intraocular_pressure1.07624473
89MP0008875_abnormal_xenobiotic_pharmacok1.05960233
90MP0003119_abnormal_digestive_system1.05305169
91MP0002697_abnormal_eye_size1.03945635
92MP0003959_abnormal_lean_body1.03402197
93MP0002118_abnormal_lipid_homeostasis1.03145085
94MP0005379_endocrine/exocrine_gland_phen1.02894836
95MP0005375_adipose_tissue_phenotype1.01119587
96MP0003315_abnormal_perineum_morphology1.00424874
97MP0000462_abnormal_digestive_system1.00353589
98MP0004185_abnormal_adipocyte_glucose1.00243078
99MP0005332_abnormal_amino_acid0.98547261
100MP0001756_abnormal_urination0.98105584
101MP0000627_abnormal_mammary_gland0.96852025
102MP0003953_abnormal_hormone_level0.96152938
103MP0005248_abnormal_Harderian_gland0.96025456
104MP0010630_abnormal_cardiac_muscle0.95399386
105MP0002098_abnormal_vibrissa_morphology0.95068323
106MP0010307_abnormal_tumor_latency0.94859922
107MP0003942_abnormal_urinary_system0.93993625
108MP0009703_decreased_birth_body0.93431120
109MP0004272_abnormal_basement_membrane0.93193326
110MP0000534_abnormal_ureter_morphology0.93174221
111MP0000733_abnormal_muscle_development0.92869063
112MP0000858_altered_metastatic_potential0.92837196
113MP0008260_abnormal_autophagy0.92554156
114MP0003890_abnormal_embryonic-extraembry0.91691281
115MP0001849_ear_inflammation0.91007037
116MP0001346_abnormal_lacrimal_gland0.90035487
117MP0000377_abnormal_hair_follicle0.88524871
118MP0008057_abnormal_DNA_replication0.88015830
119MP0000537_abnormal_urethra_morphology0.87725864
120MP0000598_abnormal_liver_morphology0.86515970
121MP0005384_cellular_phenotype0.85933190
122MP0002168_other_aberrant_phenotype0.85588673
123MP0008007_abnormal_cellular_replicative0.85025753
124MP0003806_abnormal_nucleotide_metabolis0.84470822
125MP0005310_abnormal_salivary_gland0.84301789
126MP0000428_abnormal_craniofacial_morphol0.83919164
127MP0005666_abnormal_adipose_tissue0.80266616
128MP0005408_hypopigmentation0.80097846
129MP0004808_abnormal_hematopoietic_stem0.78822571
130MP0004197_abnormal_fetal_growth/weight/0.78748150
131MP0000432_abnormal_head_morphology0.78111441
132MP0005319_abnormal_enzyme/_coenzyme0.78050982
133MP0002925_abnormal_cardiovascular_devel0.76907016
134MP0000639_abnormal_adrenal_gland0.76593025
135MP0009931_abnormal_skin_appearance0.76396403
136MP0003191_abnormal_cellular_cholesterol0.76351899
137MP0001661_extended_life_span0.76206523
138MP0001881_abnormal_mammary_gland0.76108819
139MP0010386_abnormal_urinary_bladder0.73769687
140MP0003866_abnormal_defecation0.72909630
141MP0002092_abnormal_eye_morphology0.72032126
142MP0005023_abnormal_wound_healing0.70162433
143MP0008438_abnormal_cutaneous_collagen0.70034178
144MP0005334_abnormal_fat_pad0.69891387
145MP0010678_abnormal_skin_adnexa0.69456986
146MP0000371_diluted_coat_color0.69300627
147MP0002166_altered_tumor_susceptibility0.69280753
148MP0003935_abnormal_craniofacial_develop0.69152663
149MP0002249_abnormal_larynx_morphology0.69023131
150MP0010368_abnormal_lymphatic_system0.68942768
151MP0009642_abnormal_blood_homeostasis0.66956634
152MP0005636_abnormal_mineral_homeostasis0.65247781
153MP0001270_distended_abdomen0.64522377
154MP0002086_abnormal_extraembryonic_tissu0.64122711
155MP0005670_abnormal_white_adipose0.63362803
156MP0005448_abnormal_energy_balance0.63316779
157MP0009053_abnormal_anal_canal0.60002060
158MP0003115_abnormal_respiratory_system0.55346122
159MP0002970_abnormal_white_adipose0.55281281
160MP0001299_abnormal_eye_distance/0.55171096
161MP0003123_paternal_imprinting0.54260757
162MP0005647_abnormal_sex_gland0.53196732
163MP0003122_maternal_imprinting0.52576066
164MP0002084_abnormal_developmental_patter0.50949284
165MP0003795_abnormal_bone_structure0.50875967

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.20935257
2Hypoglycemic seizures (HP:0002173)5.47415741
3Hypoglycemic coma (HP:0001325)5.11375669
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.39822628
5Abnormality of the pancreatic islet cells (HP:0006476)4.31869834
6Abnormality of endocrine pancreas physiology (HP:0012093)4.31869834
7Symptomatic seizures (HP:0011145)4.31744208
8Pancreatic islet-cell hyperplasia (HP:0004510)3.97153610
9Late onset (HP:0003584)3.96010537
10Hyperglycemia (HP:0003074)3.95108923
11Abnormality of the intrinsic pathway (HP:0010989)3.76450978
12Premature rupture of membranes (HP:0001788)3.75029532
13Ketoacidosis (HP:0001993)3.59596222
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.58985043
15Insulin-resistant diabetes mellitus (HP:0000831)3.58880465
16Abnormality of the common coagulation pathway (HP:0010990)3.48030506
17Intrahepatic cholestasis (HP:0001406)3.42451215
18Protrusio acetabuli (HP:0003179)3.30808267
19Urinary glycosaminoglycan excretion (HP:0003541)3.30230706
20Mucopolysacchariduria (HP:0008155)3.30230706
21Deep venous thrombosis (HP:0002625)3.01998154
22Flat acetabular roof (HP:0003180)2.99254223
23Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96301273
24Abnormality of polysaccharide metabolism (HP:0011012)2.96301273
25Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96301273
26Large for gestational age (HP:0001520)2.93759375
27Insulin resistance (HP:0000855)2.92196885
28Ketosis (HP:0001946)2.85564433
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82873794
30Cerebral aneurysm (HP:0004944)2.75611885
31Insomnia (HP:0100785)2.73502454
32Agitation (HP:0000713)2.72929891
33Xanthomatosis (HP:0000991)2.67815073
34Asymmetry of the thorax (HP:0001555)2.65941755
35Dysostosis multiplex (HP:0000943)2.65156891
36Back pain (HP:0003418)2.61302555
37Broad face (HP:0000283)2.60601857
38Conjugated hyperbilirubinemia (HP:0002908)2.60145049
39Unilateral renal agenesis (HP:0000122)2.57788130
40Abnormal pancreas size (HP:0012094)2.53920099
41Skin nodule (HP:0200036)2.48568549
42Ulnar bowing (HP:0003031)2.48288600
43Hand muscle atrophy (HP:0009130)2.47761219
44Shallow orbits (HP:0000586)2.47194838
45Atrophic scars (HP:0001075)2.45417717
46Abnormality of calcium-phosphate metabolism (HP:0100530)2.42748353
47Aneurysm (HP:0002617)2.39743466
48Abnormality of oral frenula (HP:0000190)2.39671687
49Retinal atrophy (HP:0001105)2.39640518
50Macroorchidism (HP:0000053)2.36826426
51Hypercortisolism (HP:0001578)2.36402973
52Abdominal distention (HP:0003270)2.35867054
53Short nail (HP:0001799)2.33965410
54Complement deficiency (HP:0004431)2.29290704
55Long palpebral fissure (HP:0000637)2.27822248
56Advanced eruption of teeth (HP:0006288)2.27619722
57Vertebral compression fractures (HP:0002953)2.27210518
58Termporal pattern (HP:0011008)2.26555229
59Insidious onset (HP:0003587)2.26555229
60Achilles tendon contracture (HP:0001771)2.26293275
61Thoracolumbar scoliosis (HP:0002944)2.21389534
62Missing ribs (HP:0000921)2.20506975
63Congenital glaucoma (HP:0001087)2.20446607
64Prominent metopic ridge (HP:0005487)2.19676373
65Disproportionate tall stature (HP:0001519)2.18401281
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.17937566
67Abnormality of the Achilles tendon (HP:0005109)2.15707962
68Exocrine pancreatic insufficiency (HP:0001738)2.15366436
69Abnormality of dentin (HP:0010299)2.14402633
70Cholecystitis (HP:0001082)2.13876017
71Abnormal gallbladder physiology (HP:0012438)2.13876017
72Deviation of the thumb (HP:0009603)2.11883104
73Arterial tortuosity (HP:0005116)2.10695044
74Abnormality of carpal bone ossification (HP:0006257)2.09385096
75Upper limb amyotrophy (HP:0009129)2.08091537
76Distal upper limb amyotrophy (HP:0007149)2.08091537
77Selective tooth agenesis (HP:0001592)2.07196004
78Turricephaly (HP:0000262)2.04812133
79Fragile skin (HP:0001030)2.03800804
80Restlessness (HP:0000711)2.03412339
81Increased nuchal translucency (HP:0010880)2.03395146
82Renal duplication (HP:0000075)2.02651082
83Fat malabsorption (HP:0002630)2.02143282
84Abnormal ossification of hand bones (HP:0005921)2.01902101
85Natal tooth (HP:0000695)2.01709563
86Patellar dislocation (HP:0002999)2.00890497
87Severe short stature (HP:0003510)2.00346172
88Distal lower limb amyotrophy (HP:0008944)1.98200260
89Overriding aorta (HP:0002623)1.96174699
90Cerebral inclusion bodies (HP:0100314)1.95947135
91Blue sclerae (HP:0000592)1.95943820
92Epidermoid cyst (HP:0200040)1.93973339
93Abnormality of the metopic suture (HP:0005556)1.91716965
94Right ventricular cardiomyopathy (HP:0011663)1.91443516
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.90780235
96Osteolytic defects of the hand bones (HP:0009699)1.90780235
97Trismus (HP:0000211)1.89714535
98Hyperparathyroidism (HP:0000843)1.89701572
99Cortical dysplasia (HP:0002539)1.88729193
100Pterygium (HP:0001059)1.88495338
101Dysmetric saccades (HP:0000641)1.87852904
102Overlapping toe (HP:0001845)1.87611398
103Renovascular hypertension (HP:0100817)1.87199896
104Subacute progressive viral hepatitis (HP:0006572)1.87134658
105Bladder diverticulum (HP:0000015)1.86520301
106Abnormality of the acetabulum (HP:0003170)1.86367717
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.86270257
108Resting tremor (HP:0002322)1.85978368
109Abnormality of the distal phalanges of the toes (HP:0010182)1.85403488
110Protuberant abdomen (HP:0001538)1.84773312
111Abnormality of complement system (HP:0005339)1.84493762
112Bronchomalacia (HP:0002780)1.83613963
113Long toe (HP:0010511)1.83251850
114Reticulocytosis (HP:0001923)1.83030036
115Global brain atrophy (HP:0002283)1.81440024
116Progressive hearing impairment (HP:0001730)1.81432367
117Hyperacusis (HP:0010780)1.81398777
118Arnold-Chiari malformation (HP:0002308)1.81397762
119Wormian bones (HP:0002645)1.81176877
120Myocardial infarction (HP:0001658)1.80466447
121Elfin facies (HP:0004428)1.79946574
122Increased CSF protein (HP:0002922)1.79823567
123Striae distensae (HP:0001065)1.79776943
124Prolonged partial thromboplastin time (HP:0003645)1.79774535
125Thin bony cortex (HP:0002753)1.79407379
126Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79298984
127Enlarged penis (HP:0000040)1.79201928
128Elevated alkaline phosphatase (HP:0003155)1.78913548
129Vascular tortuosity (HP:0004948)1.77139883
130Abnormal enzyme/coenzyme activity (HP:0012379)1.76782861
131Abnormality of alkaline phosphatase activity (HP:0004379)1.75842213
132Flattened epiphyses (HP:0003071)1.75799473
133Hypokalemia (HP:0002900)1.75360352
134Abnormality of the salivary glands (HP:0010286)1.75342040
135Papilledema (HP:0001085)1.75155383
136Spinal rigidity (HP:0003306)1.73318568
137Abnormality of sulfur amino acid metabolism (HP:0004339)1.72916475
138Biconcave vertebral bodies (HP:0004586)1.72742226
139Proximal placement of thumb (HP:0009623)1.72730243
140Vertebral arch anomaly (HP:0008438)1.71451798
141Abnormal foot bone ossification (HP:0010675)1.70386633
142Ankle contracture (HP:0006466)1.69514392
143Increased connective tissue (HP:0009025)1.69000625
144Abnormality of purine metabolism (HP:0004352)1.68983842
145Midface retrusion (HP:0011800)1.68860415
146Relative macrocephaly (HP:0004482)1.68091974
147Premature skin wrinkling (HP:0100678)1.67952343
148Long eyelashes (HP:0000527)1.67802986
149Menorrhagia (HP:0000132)1.66821396
150Hypophosphatemia (HP:0002148)1.65697672
151Cervical subluxation (HP:0003308)1.64673635
152Hammertoe (HP:0001765)1.64177324
153Limb hypertonia (HP:0002509)1.63322902
154Abnormal tarsal ossification (HP:0008369)1.62786075
155Bowel diverticulosis (HP:0005222)1.62637337
156Neonatal death (HP:0003811)1.62144860
157Hepatocellular carcinoma (HP:0001402)1.62144620
158Pseudobulbar signs (HP:0002200)1.61143951
159Upper limb muscle weakness (HP:0003484)1.60794138
160Abnormal biliary tract morphology (HP:0012440)1.59091304
161Decreased circulating renin level (HP:0003351)1.59065445
162Micronodular cirrhosis (HP:0001413)1.58994314
163Abnormality of the thoracic spine (HP:0100711)1.58562161
164Spastic diplegia (HP:0001264)1.58343274
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57137501
166Urethral obstruction (HP:0000796)1.56795456
167Gout (HP:0001997)1.56503596
168Mitral valve prolapse (HP:0001634)1.56287987
169Lymphangioma (HP:0100764)1.56278854
170Lower limb amyotrophy (HP:0007210)1.55975112
171Small epiphyses (HP:0010585)1.55941860
172Breech presentation (HP:0001623)1.55581850
173Generalized aminoaciduria (HP:0002909)1.54243232
174Abnormality of the gastric mucosa (HP:0004295)1.54161671
175Hypobetalipoproteinemia (HP:0003563)1.54070954
176Septate vagina (HP:0001153)1.53902456
177Hemorrhage of the eye (HP:0011885)1.53661327
178Pili torti (HP:0003777)1.53632581
179Heterotopia (HP:0002282)1.53602189
180Mildly elevated creatine phosphokinase (HP:0008180)1.53122532
181Microglossia (HP:0000171)1.52615310
182Abnormal delivery (HP:0001787)1.52290457
183Spinal cord compression (HP:0002176)1.52032623
184Coxa vara (HP:0002812)1.51810067
185Rectal prolapse (HP:0002035)1.50896877
186Death in childhood (HP:0003819)1.50781299
187Lower limb hyperreflexia (HP:0002395)1.49111509
188Ankyloglossia (HP:0010296)1.48548186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.74194830
2TAOK34.22814274
3INSRR4.04166467
4SMG13.80692339
5PASK3.77591556
6TRIB33.73637478
7PKN22.64192394
8SCYL22.49015783
9FRK2.41690194
10LATS12.39617251
11EEF2K2.35534057
12SIK12.34145233
13PTK62.26913700
14LATS22.26826961
15PDGFRA2.22908639
16CDK122.14813853
17PRKD32.10346027
18HIPK21.96982680
19MAP3K101.95771281
20MAP3K21.93563184
21FLT31.81506427
22PRPF4B1.81446937
23TSSK61.64444346
24LMTK21.53992315
25TTK1.47211658
26MAP3K91.45145168
27MAPK151.41890816
28MAP3K11.40390172
29FGFR41.35972363
30RIPK11.33847401
31PTK21.30318858
32BCKDK1.28325788
33MTOR1.26848343
34EPHA21.22029951
35ICK1.21802744
36PRKCH1.13526154
37SRPK11.13462002
38CDK71.12486499
39ALK1.09377528
40ARAF1.08757634
41AKT31.07526060
42EIF2AK11.02932037
43MET1.01274208
44JAK20.99341657
45RET0.96754946
46NME20.93325265
47FER0.92745054
48PRKD20.91560795
49EPHA30.90172444
50DYRK1B0.89576370
51NTRK10.86821883
52CDC42BPA0.86795283
53PAK20.86749005
54CAMK1G0.83617233
55BMX0.83067588
56JAK10.81204132
57TTN0.79330933
58EPHB10.79037748
59CAMK1D0.78225767
60FGFR30.77619613
61BRAF0.76874305
62TYRO30.74874505
63IRAK30.74134624
64PDGFRB0.73868757
65CDC70.73513106
66LRRK20.70169588
67CDK60.68724013
68MAP2K20.68239067
69CLK10.66603876
70UHMK10.65235495
71MAPK110.65010110
72CHEK10.64398811
73WNK40.64383011
74PNCK0.63108861
75MAP3K130.60389335
76TESK10.59609449
77STK30.59322463
78BRD40.59175791
79PRKAA10.59104000
80PBK0.57435607
81TESK20.57166561
82PRKG20.56993204
83CDK80.56968523
84EIF2AK30.56778647
85CDK90.56621135
86VRK20.56395516
87PAK40.55846351
88GSK3A0.54086996
89RPS6KA20.52564267
90KSR20.52538640
91CAMKK10.51865102
92PDPK10.49615272
93JAK30.47854792
94MAP3K30.47518781
95PRKD10.46662910
96TAOK20.46604268
97CSK0.46366094
98TAF10.45668600
99CHEK20.43717583
100STK380.43643516
101PAK30.43466912
102BUB10.43270772
103BRSK20.42754131
104CDK10.42304571
105SGK30.42103145
106PIK3CG0.41881445
107MAP3K80.41679479
108CDK20.40813946
109RPS6KB20.40379767
110AURKB0.39964842
111ZAP700.39689470
112ROCK20.39335804
113BRSK10.39174370
114AURKA0.39152771
115DDR20.39019876
116AKT20.38481776
117MAP3K70.37811271
118MST1R0.37375332
119NEK10.36817152
120CHUK0.34678468
121MAPK100.34516790
122CDK11A0.34176544
123CDK150.34010093
124WNK10.33663240
125BTK0.33006117
126MAPK140.32065315
127TAOK10.32040190
128PRKCI0.31158583
129RPS6KB10.30500875
130PRKDC0.29664953
131EGFR0.29577855
132MAPKAPK30.29257846
133STK100.28408542
134MARK20.27125179
135FGFR10.27101925
136ITK0.27059964
137ERBB40.26591164
138FGFR20.26371150
139CDK40.25983905
140NEK20.25615763
141CAMKK20.25456084
142TYK20.24869649

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.70858973
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.48365708
3Selenocompound metabolism_Homo sapiens_hsa004502.69001350
4Nitrogen metabolism_Homo sapiens_hsa009102.63578030
5Protein export_Homo sapiens_hsa030602.27362151
6Sulfur metabolism_Homo sapiens_hsa009202.25730076
7Type II diabetes mellitus_Homo sapiens_hsa049302.09846081
8N-Glycan biosynthesis_Homo sapiens_hsa005101.82084204
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.81703338
10Tryptophan metabolism_Homo sapiens_hsa003801.79387474
11Insulin secretion_Homo sapiens_hsa049111.71849288
12Arginine biosynthesis_Homo sapiens_hsa002201.63361859
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62081950
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59011915
15Fatty acid biosynthesis_Homo sapiens_hsa000611.55335785
16Fat digestion and absorption_Homo sapiens_hsa049751.53753892
17Lysine degradation_Homo sapiens_hsa003101.53248202
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52546713
19Pentose phosphate pathway_Homo sapiens_hsa000301.48265020
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46382445
21Insulin resistance_Homo sapiens_hsa049311.42980718
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42719061
23ECM-receptor interaction_Homo sapiens_hsa045121.42372293
24Fructose and mannose metabolism_Homo sapiens_hsa000511.42102415
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41025019
26ABC transporters_Homo sapiens_hsa020101.39699629
27DNA replication_Homo sapiens_hsa030301.37998709
28One carbon pool by folate_Homo sapiens_hsa006701.37218776
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.34504044
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28593657
31Carbon metabolism_Homo sapiens_hsa012001.27641477
32Complement and coagulation cascades_Homo sapiens_hsa046101.27638266
33Type I diabetes mellitus_Homo sapiens_hsa049401.27564290
34mRNA surveillance pathway_Homo sapiens_hsa030151.24653710
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.21870574
36Vitamin B6 metabolism_Homo sapiens_hsa007501.21645013
37Pancreatic cancer_Homo sapiens_hsa052121.20238820
38Cell cycle_Homo sapiens_hsa041101.14206265
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13053752
40Prion diseases_Homo sapiens_hsa050201.09087137
41Notch signaling pathway_Homo sapiens_hsa043301.08829808
42Bile secretion_Homo sapiens_hsa049761.08642223
43Thyroid hormone synthesis_Homo sapiens_hsa049181.07932580
44mTOR signaling pathway_Homo sapiens_hsa041501.07328974
45ErbB signaling pathway_Homo sapiens_hsa040121.07084054
46Starch and sucrose metabolism_Homo sapiens_hsa005001.06983489
47Fatty acid degradation_Homo sapiens_hsa000711.05966510
48Glucagon signaling pathway_Homo sapiens_hsa049221.04976986
49Bladder cancer_Homo sapiens_hsa052191.01706941
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00831726
51Renal cell carcinoma_Homo sapiens_hsa052110.99977789
52RNA transport_Homo sapiens_hsa030130.99268826
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98811267
54VEGF signaling pathway_Homo sapiens_hsa043700.98333217
55Pancreatic secretion_Homo sapiens_hsa049720.94369158
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92022477
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91720920
58Tight junction_Homo sapiens_hsa045300.89774202
59Steroid biosynthesis_Homo sapiens_hsa001000.89108478
60Protein digestion and absorption_Homo sapiens_hsa049740.88895035
61Lysosome_Homo sapiens_hsa041420.88161955
62Hippo signaling pathway_Homo sapiens_hsa043900.87159920
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83013828
64Spliceosome_Homo sapiens_hsa030400.82766645
65Antigen processing and presentation_Homo sapiens_hsa046120.78787958
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78241823
67Prolactin signaling pathway_Homo sapiens_hsa049170.77882511
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.76459095
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76101998
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75645534
71HIF-1 signaling pathway_Homo sapiens_hsa040660.75560495
72Prostate cancer_Homo sapiens_hsa052150.74792372
73Dorso-ventral axis formation_Homo sapiens_hsa043200.74143893
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73228469
75Chronic myeloid leukemia_Homo sapiens_hsa052200.72883458
76Estrogen signaling pathway_Homo sapiens_hsa049150.71569464
77Thyroid cancer_Homo sapiens_hsa052160.71051669
78Insulin signaling pathway_Homo sapiens_hsa049100.70951009
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68706977
80Endometrial cancer_Homo sapiens_hsa052130.68452324
81Colorectal cancer_Homo sapiens_hsa052100.68434502
82Butanoate metabolism_Homo sapiens_hsa006500.65704153
83PPAR signaling pathway_Homo sapiens_hsa033200.64720996
84AMPK signaling pathway_Homo sapiens_hsa041520.63945731
85Galactose metabolism_Homo sapiens_hsa000520.63024618
86Adherens junction_Homo sapiens_hsa045200.62772023
87Basal cell carcinoma_Homo sapiens_hsa052170.62515341
88Apoptosis_Homo sapiens_hsa042100.59993589
89Amoebiasis_Homo sapiens_hsa051460.59706749
90Arginine and proline metabolism_Homo sapiens_hsa003300.57991327
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.57768189
92Other glycan degradation_Homo sapiens_hsa005110.57322275
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57099566
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.56883073
95Focal adhesion_Homo sapiens_hsa045100.56485776
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56397361
97Fatty acid metabolism_Homo sapiens_hsa012120.55956383
98Phenylalanine metabolism_Homo sapiens_hsa003600.55637720
99Pathways in cancer_Homo sapiens_hsa052000.55220862
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54741001
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53349672
102Biosynthesis of amino acids_Homo sapiens_hsa012300.52332355
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52134801
104Histidine metabolism_Homo sapiens_hsa003400.52020555
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51646893
106Wnt signaling pathway_Homo sapiens_hsa043100.51352182
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.51311873
108Vibrio cholerae infection_Homo sapiens_hsa051100.51102557
109Hepatitis C_Homo sapiens_hsa051600.50664801
110Melanogenesis_Homo sapiens_hsa049160.50488377
111Base excision repair_Homo sapiens_hsa034100.50153236
112Melanoma_Homo sapiens_hsa052180.49953028
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48770463
114Hepatitis B_Homo sapiens_hsa051610.48649289
115Shigellosis_Homo sapiens_hsa051310.48433506
116Folate biosynthesis_Homo sapiens_hsa007900.48343091
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48074004
118Cocaine addiction_Homo sapiens_hsa050300.48066693
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47275321
120Pyruvate metabolism_Homo sapiens_hsa006200.46275636
121Proteoglycans in cancer_Homo sapiens_hsa052050.45673052
122Staphylococcus aureus infection_Homo sapiens_hsa051500.45317666
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44905306
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43685104
125Small cell lung cancer_Homo sapiens_hsa052220.43415213
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43166633
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42723244
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41872748
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41268642
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.40747947
131Glycerolipid metabolism_Homo sapiens_hsa005610.39497105
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38732612
133Renin-angiotensin system_Homo sapiens_hsa046140.38664535
134Non-small cell lung cancer_Homo sapiens_hsa052230.37794958
135Acute myeloid leukemia_Homo sapiens_hsa052210.36439337
136Viral carcinogenesis_Homo sapiens_hsa052030.33823077
137Tyrosine metabolism_Homo sapiens_hsa003500.32687794
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31795473
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31345058
140Glioma_Homo sapiens_hsa052140.31047216
141Inositol phosphate metabolism_Homo sapiens_hsa005620.30890130
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30302380
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27240600
144Caffeine metabolism_Homo sapiens_hsa002320.27157396
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25566719
146MicroRNAs in cancer_Homo sapiens_hsa052060.25208837

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