HYDIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin metabolic process (GO:0042428)4.91405315
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.88074392
3astrocyte differentiation (GO:0048708)4.36973716
4primary amino compound metabolic process (GO:1901160)4.27948295
5L-amino acid import (GO:0043092)4.24955568
6presynaptic membrane assembly (GO:0097105)4.12911105
7negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97810192
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.89025283
9central nervous system myelination (GO:0022010)3.87927965
10axon ensheathment in central nervous system (GO:0032291)3.87927965
11presynaptic membrane organization (GO:0097090)3.75072640
12membrane depolarization during action potential (GO:0086010)3.67257970
13negative regulation of neurotransmitter transport (GO:0051589)3.64533347
14astrocyte development (GO:0014002)3.62050919
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.60628324
16dermatan sulfate biosynthetic process (GO:0030208)3.51809858
17dopamine transport (GO:0015872)3.50172765
18regulation of cytokine production involved in inflammatory response (GO:1900015)3.48969074
19postsynaptic membrane organization (GO:0001941)3.41799103
20regulation of glucocorticoid secretion (GO:2000849)3.35151968
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29124689
22synaptic transmission, glutamatergic (GO:0035249)3.27319013
23photoreceptor cell differentiation (GO:0046530)3.21139609
24eye photoreceptor cell differentiation (GO:0001754)3.21139609
25positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.20919031
26glutamate receptor signaling pathway (GO:0007215)3.19010925
27dermatan sulfate metabolic process (GO:0030205)3.17741866
28amino acid import (GO:0043090)3.14882738
29catecholamine transport (GO:0051937)3.05534793
30neuron cell-cell adhesion (GO:0007158)3.02200307
31auditory behavior (GO:0031223)2.99952852
32positive regulation of synapse maturation (GO:0090129)2.99029766
33synaptic vesicle maturation (GO:0016188)2.97772209
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95510933
35startle response (GO:0001964)2.95244184
36positive regulation of vascular permeability (GO:0043117)2.91972413
37vocalization behavior (GO:0071625)2.89977399
38neuronal ion channel clustering (GO:0045161)2.87165444
39insulin secretion (GO:0030073)2.82416915
40transmission of nerve impulse (GO:0019226)2.81864742
41L-fucose catabolic process (GO:0042355)2.81749640
42fucose catabolic process (GO:0019317)2.81749640
43L-fucose metabolic process (GO:0042354)2.81749640
44neuron-neuron synaptic transmission (GO:0007270)2.81590188
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81520483
46gamma-aminobutyric acid transport (GO:0015812)2.80044173
47urinary tract smooth muscle contraction (GO:0014848)2.78843355
48water-soluble vitamin biosynthetic process (GO:0042364)2.77335230
49regulation of corticosteroid hormone secretion (GO:2000846)2.77148558
50positive regulation of membrane potential (GO:0045838)2.76314482
51response to auditory stimulus (GO:0010996)2.75297236
52regulation of synapse maturation (GO:0090128)2.69284203
53DNA damage induced protein phosphorylation (GO:0006975)2.67981773
54neurotransmitter secretion (GO:0007269)2.67662747
55positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.67377179
56protein localization to synapse (GO:0035418)2.66746647
57regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.64525338
58C4-dicarboxylate transport (GO:0015740)2.64103106
59membrane depolarization (GO:0051899)2.64056712
60neuron recognition (GO:0008038)2.63788011
61toxin metabolic process (GO:0009404)2.63176330
62neuronal action potential propagation (GO:0019227)2.63108874
63axonal fasciculation (GO:0007413)2.62580878
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61429787
65response to corticosterone (GO:0051412)2.60883194
66neuronal action potential (GO:0019228)2.59251770
67neurotransmitter-gated ion channel clustering (GO:0072578)2.59165894
68nonmotile primary cilium assembly (GO:0035058)2.58527862
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58098763
70central nervous system projection neuron axonogenesis (GO:0021952)2.57808388
71myelination (GO:0042552)2.56823584
72dopamine biosynthetic process (GO:0042416)2.55677459
73central nervous system neuron axonogenesis (GO:0021955)2.55200396
74cerebellar Purkinje cell differentiation (GO:0021702)2.54207471
75cerebellar granule cell differentiation (GO:0021707)2.54085015
76protein-chromophore linkage (GO:0018298)2.53969115
77locomotory exploration behavior (GO:0035641)2.53961942
78synaptic vesicle exocytosis (GO:0016079)2.53556597
79indole-containing compound metabolic process (GO:0042430)2.52191821
80positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.52112797
81phosphorelay signal transduction system (GO:0000160)2.52055899
82musculoskeletal movement (GO:0050881)2.50969263
83multicellular organismal movement (GO:0050879)2.50969263
84cochlea development (GO:0090102)2.50239932
85adult walking behavior (GO:0007628)2.49545596
86regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47751984
87positive regulation of dendritic spine development (GO:0060999)2.47719065
88interkinetic nuclear migration (GO:0022027)2.46985514
89proline transport (GO:0015824)2.46820912
90regulation of neuronal synaptic plasticity (GO:0048168)2.46660085
91reflex (GO:0060004)2.46410186
92mechanosensory behavior (GO:0007638)2.45679999
93regulation of calcium ion-dependent exocytosis (GO:0017158)2.45416850
94kidney morphogenesis (GO:0060993)2.43710659
95ensheathment of neurons (GO:0007272)2.43656469
96axon ensheathment (GO:0008366)2.43656469
97epithelial cell fate commitment (GO:0072148)2.42889978
98substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41062208
99substrate-independent telencephalic tangential migration (GO:0021826)2.41062208
100glutamate secretion (GO:0014047)2.40129330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.71665704
2EZH2_22144423_ChIP-Seq_EOC_Human3.10129039
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57857048
4DROSHA_22980978_ChIP-Seq_HELA_Human2.29909385
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28618260
6TAF15_26573619_Chip-Seq_HEK293_Human2.26714868
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25682208
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22209427
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17936445
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11271166
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.08291422
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03295524
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96589311
14SMAD4_21799915_ChIP-Seq_A2780_Human1.95914361
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94428962
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90696653
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89133477
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84855273
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79721321
20REST_21632747_ChIP-Seq_MESCs_Mouse1.72227283
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68904643
22STAT3_23295773_ChIP-Seq_U87_Human1.68682857
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68454387
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66200217
25AHR_22903824_ChIP-Seq_MCF-7_Human1.64432343
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.62307905
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.58553423
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58450707
29P300_19829295_ChIP-Seq_ESCs_Human1.56722089
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55826226
31TCF4_23295773_ChIP-Seq_U87_Human1.55196562
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55066477
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53339363
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47698752
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47439440
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44741979
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.44401396
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.44076778
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.42997615
40AR_21572438_ChIP-Seq_LNCaP_Human1.42182445
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41657213
42VDR_22108803_ChIP-Seq_LS180_Human1.41180042
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40948641
44TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40070897
45TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39432785
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39191889
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39191889
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38295419
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37856684
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37785646
51AR_25329375_ChIP-Seq_VCAP_Human1.37453732
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37439051
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36920278
54TP53_16413492_ChIP-PET_HCT116_Human1.36001474
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34567982
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33995349
57FUS_26573619_Chip-Seq_HEK293_Human1.33489379
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.32416076
59SMAD3_21741376_ChIP-Seq_HESCs_Human1.31716272
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.31658440
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31519648
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.31344777
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.30388725
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25882996
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25882996
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.25880819
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25433000
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24078441
69BCAT_22108803_ChIP-Seq_LS180_Human1.22477756
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20005851
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.19860201
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19698107
73RUNX2_22187159_ChIP-Seq_PCA_Human1.19614573
74IGF1R_20145208_ChIP-Seq_DFB_Human1.19184540
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18861292
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.18577155
77KDM2B_26808549_Chip-Seq_REH_Human1.18344317
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18325420
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16529892
80SMAD4_21741376_ChIP-Seq_HESCs_Human1.14139042
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.13180118
82AR_19668381_ChIP-Seq_PC3_Human1.12739170
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12652813
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12581304
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12240232
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11650928
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.10832036
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10435372
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10435372
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09853076
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.09509917
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.09340441
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.08638852
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06806505
95CBP_20019798_ChIP-Seq_JUKART_Human1.06559127
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06559127
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06401662
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06245136
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.05879008
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05235855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex3.89511924
2MP0009046_muscle_twitch3.77564904
3MP0004859_abnormal_synaptic_plasticity3.47625338
4MP0003880_abnormal_central_pattern3.08661946
5MP0004270_analgesia3.04635669
6MP0001968_abnormal_touch/_nociception3.00440389
7MP0001501_abnormal_sleep_pattern2.85123824
8MP0003635_abnormal_synaptic_transmissio2.75574913
9MP0002064_seizures2.74977584
10MP0002736_abnormal_nociception_after2.69745792
11MP0009745_abnormal_behavioral_response2.69311792
12MP0002735_abnormal_chemical_nociception2.68163076
13MP0001502_abnormal_circadian_rhythm2.48248618
14MP0002272_abnormal_nervous_system2.40706275
15MP0002572_abnormal_emotion/affect_behav2.38399335
16MP0001486_abnormal_startle_reflex2.27949187
17MP0002063_abnormal_learning/memory/cond2.26143400
18MP0002909_abnormal_adrenal_gland2.24361932
19MP0002734_abnormal_mechanical_nocicepti2.24276923
20MP0005423_abnormal_somatic_nervous2.20889060
21MP0006276_abnormal_autonomic_nervous2.20170324
22MP0003879_abnormal_hair_cell2.16697639
23MP0009780_abnormal_chondrocyte_physiolo2.16124080
24MP0001984_abnormal_olfaction2.12690527
25MP0010386_abnormal_urinary_bladder2.10434989
26MP0001970_abnormal_pain_threshold1.92516481
27MP0000778_abnormal_nervous_system1.79456974
28MP0000569_abnormal_digit_pigmentation1.75814147
29MP0003633_abnormal_nervous_system1.75103308
30MP0005551_abnormal_eye_electrophysiolog1.74922475
31MP0002733_abnormal_thermal_nociception1.74425616
32MP0002557_abnormal_social/conspecific_i1.66773772
33MP0004885_abnormal_endolymph1.64280053
34MP0003690_abnormal_glial_cell1.61878525
35MP0001485_abnormal_pinna_reflex1.60021606
36MP0002067_abnormal_sensory_capabilities1.59951627
37MP0005386_behavior/neurological_phenoty1.53728405
38MP0004924_abnormal_behavior1.53728405
39MP0005253_abnormal_eye_physiology1.52239086
40MP0003631_nervous_system_phenotype1.51442233
41MP0003632_abnormal_nervous_system1.50025750
42MP0005646_abnormal_pituitary_gland1.46193164
43MP0001905_abnormal_dopamine_level1.45135670
44MP0003045_fibrosis1.42707330
45MP0002882_abnormal_neuron_morphology1.34638161
46MP0003195_calcinosis1.33454467
47MP0003950_abnormal_plasma_membrane1.28565075
48MP0005503_abnormal_tendon_morphology1.27030562
49MP0008569_lethality_at_weaning1.26391510
50MP0002229_neurodegeneration1.24807602
51MP0001440_abnormal_grooming_behavior1.20599415
52MP0003634_abnormal_glial_cell1.17957852
53MP0000920_abnormal_myelination1.17301237
54MP0008872_abnormal_physiological_respon1.16209557
55MP0004811_abnormal_neuron_physiology1.16122087
56MP0006072_abnormal_retinal_apoptosis1.15237703
57MP0000955_abnormal_spinal_cord1.11092288
58MP0003283_abnormal_digestive_organ1.08908776
59MP0002066_abnormal_motor_capabilities/c1.05938180
60MP0002876_abnormal_thyroid_physiology1.04233217
61MP0003136_yellow_coat_color1.03230080
62MP0002184_abnormal_innervation1.02152520
63MP0004742_abnormal_vestibular_system0.99744940
64MP0005595_abnormal_vascular_smooth0.97607400
65MP0003787_abnormal_imprinting0.96908345
66MP0000383_abnormal_hair_follicle0.96898818
67MP0000631_abnormal_neuroendocrine_gland0.96010578
68MP0002168_other_aberrant_phenotype0.94927647
69MP0001986_abnormal_taste_sensitivity0.94893534
70MP0001963_abnormal_hearing_physiology0.92888785
71MP0004085_abnormal_heartbeat0.90224952
72MP0005379_endocrine/exocrine_gland_phen0.89970688
73MP0005535_abnormal_body_temperature0.88479065
74MP0002653_abnormal_ependyma_morphology0.88167436
75MP0003137_abnormal_impulse_conducting0.87664042
76MP0005275_abnormal_skin_tensile0.85418867
77MP0005187_abnormal_penis_morphology0.82283979
78MP0002752_abnormal_somatic_nervous0.81258261
79MP0001944_abnormal_pancreas_morphology0.80455450
80MP0002152_abnormal_brain_morphology0.78698297
81MP0004043_abnormal_pH_regulation0.77865702
82MP0001177_atelectasis0.75798465
83MP0000026_abnormal_inner_ear0.75390243
84MP0005645_abnormal_hypothalamus_physiol0.75106929
85MP0002102_abnormal_ear_morphology0.71729452
86MP0003329_amyloid_beta_deposits0.71542229
87MP0002693_abnormal_pancreas_physiology0.71472938
88MP0004215_abnormal_myocardial_fiber0.71022304
89MP0005195_abnormal_posterior_eye0.65887653
90MP0000534_abnormal_ureter_morphology0.64788417
91MP0002069_abnormal_eating/drinking_beha0.63787780
92MP0005248_abnormal_Harderian_gland0.63315033
93MP0002078_abnormal_glucose_homeostasis0.61213266
94MP0000566_synostosis0.60954711
95MP0004142_abnormal_muscle_tone0.59353409
96MP0000462_abnormal_digestive_system0.59129115
97MP0001529_abnormal_vocalization0.58695646
98MP0000613_abnormal_salivary_gland0.58561916
99MP0000230_abnormal_systemic_arterial0.58000762
100MP0001299_abnormal_eye_distance/0.57018854

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)6.71212105
2Limb dystonia (HP:0002451)4.38341320
3Focal motor seizures (HP:0011153)4.07967087
4Diastasis recti (HP:0001540)4.02977101
5Mesangial abnormality (HP:0001966)3.75363437
6Distal arthrogryposis (HP:0005684)3.53269824
7Progressive cerebellar ataxia (HP:0002073)3.41359643
8Action tremor (HP:0002345)3.27871089
9Focal seizures (HP:0007359)3.22647926
10Absent speech (HP:0001344)3.15663468
11Epileptic encephalopathy (HP:0200134)3.10764433
12Difficulty running (HP:0009046)3.06088877
13Epileptiform EEG discharges (HP:0011182)3.02326285
14Metaphyseal dysplasia (HP:0100255)3.01403807
15Gaze-evoked nystagmus (HP:0000640)2.98135448
16Febrile seizures (HP:0002373)2.97462952
17Diplopia (HP:0000651)2.96158462
18Abnormality of binocular vision (HP:0011514)2.96158462
19Broad-based gait (HP:0002136)2.88133302
20Genetic anticipation (HP:0003743)2.79530161
21EEG with generalized epileptiform discharges (HP:0011198)2.79274620
22Hemiparesis (HP:0001269)2.69927448
23Hypsarrhythmia (HP:0002521)2.66683091
24Decreased circulating renin level (HP:0003351)2.51460608
25Abnormality of the ischium (HP:0003174)2.50173989
26Gait imbalance (HP:0002141)2.48251832
27Myokymia (HP:0002411)2.45613150
28Metabolic alkalosis (HP:0200114)2.44806959
29Hypothermia (HP:0002045)2.38728689
30Alacrima (HP:0000522)2.36597731
31Decreased lacrimation (HP:0000633)2.34032278
32Hypoplastic ischia (HP:0003175)2.32546111
33Hemiplegia (HP:0002301)2.31609214
34Dialeptic seizures (HP:0011146)2.30951711
35Bony spicule pigmentary retinopathy (HP:0007737)2.27855061
36Aplasia involving bones of the upper limbs (HP:0009823)2.25489842
37Aplasia of the phalanges of the hand (HP:0009802)2.25489842
38Aplasia involving bones of the extremities (HP:0009825)2.25489842
39Drooling (HP:0002307)2.24095321
40Hepatoblastoma (HP:0002884)2.22354259
41Atonic seizures (HP:0010819)2.22072048
42Absent frontal sinuses (HP:0002688)2.20698703
43Protruding tongue (HP:0010808)2.20531443
44Tubulointerstitial nephritis (HP:0001970)2.20369105
45Attenuation of retinal blood vessels (HP:0007843)2.19191574
46Cutaneous finger syndactyly (HP:0010554)2.16702688
47Medial flaring of the eyebrow (HP:0010747)2.16546825
48Generalized tonic-clonic seizures (HP:0002069)2.15612761
49Widely spaced teeth (HP:0000687)2.13553522
50Congenital primary aphakia (HP:0007707)2.13389756
51Abnormal ciliary motility (HP:0012262)2.08852675
52Cerebral hypomyelination (HP:0006808)2.08106090
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07004803
54Prolonged QT interval (HP:0001657)2.06507732
55Pancreatic fibrosis (HP:0100732)2.05436261
56Genital tract atresia (HP:0001827)2.04572371
57Congenital sensorineural hearing impairment (HP:0008527)2.04328965
58Absence seizures (HP:0002121)2.03908087
59Excessive salivation (HP:0003781)2.01643932
60Nephrogenic diabetes insipidus (HP:0009806)2.00294138
61Lower limb muscle weakness (HP:0007340)1.98047127
62Nephronophthisis (HP:0000090)1.96258698
63Syncope (HP:0001279)1.94423300
64Prominent supraorbital ridges (HP:0000336)1.91889675
65Megalencephaly (HP:0001355)1.90596192
66Abnormality of the renal medulla (HP:0100957)1.90106885
67Vaginal atresia (HP:0000148)1.89945378
68Abnormal pupillary function (HP:0007686)1.89396478
69Agitation (HP:0000713)1.86159390
70Poor eye contact (HP:0000817)1.86150459
71Preaxial foot polydactyly (HP:0001841)1.83626028
72Short foot (HP:0001773)1.82647341
73Limb hypertonia (HP:0002509)1.82064172
74Abnormality of renin-angiotensin system (HP:0000847)1.80580551
75Choroideremia (HP:0001139)1.80494088
76Tubulointerstitial abnormality (HP:0001969)1.79357141
77Urinary bladder sphincter dysfunction (HP:0002839)1.76576452
78Abnormality of incisor morphology (HP:0011063)1.76093374
79Fragile skin (HP:0001030)1.75387193
80Pancreatic cysts (HP:0001737)1.74521783
81Focal segmental glomerulosclerosis (HP:0000097)1.74411700
82Abnormal rod and cone electroretinograms (HP:0008323)1.73511737
83Truncal ataxia (HP:0002078)1.73311570
84Protuberant abdomen (HP:0001538)1.72891967
85True hermaphroditism (HP:0010459)1.72740618
86Hypoplastic nipples (HP:0002557)1.71497186
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71332622
88Bifid tongue (HP:0010297)1.71219033
89Postural instability (HP:0002172)1.69676098
90Thin upper lip vermilion (HP:0000219)1.69279609
91Protruding ear (HP:0000411)1.68668952
92Tetraplegia (HP:0002445)1.68378919
93Abnormal drinking behavior (HP:0030082)1.68087547
94Polydipsia (HP:0001959)1.68087547
95Short chin (HP:0000331)1.67304409
96Increased circulating renin level (HP:0000848)1.66469896
97Large eyes (HP:0001090)1.66167773
98Fair hair (HP:0002286)1.65348158
99Cutaneous syndactyly (HP:0012725)1.65001035
100Cystic liver disease (HP:0006706)1.63331427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.67481272
2CASK4.01547428
3NTRK33.64351952
4MARK12.94040111
5PIK3CG2.59693955
6SGK22.42475742
7CSNK1G12.20812682
8INSRR2.20510076
9FGFR22.19180685
10EPHA42.13918137
11MAP3K42.11025486
12CSNK1G22.09254293
13TNIK2.09106930
14CSNK1G32.03216143
15NTRK22.03089432
16DAPK21.98420810
17SGK4941.92899345
18SGK2231.92899345
19PNCK1.79437170
20MAPK131.71157699
21SGK31.59274503
22PHKG11.42997889
23PHKG21.42997889
24LATS11.31948697
25CDK121.31078849
26PINK11.22623492
27PDK21.18577562
28CCNB11.17416015
29STK38L1.15824955
30AKT31.14751897
31DMPK1.14153010
32WNK31.12493284
33ADRBK21.12425769
34MAP2K71.07724782
35UHMK11.06747964
36SGK11.04808142
37CAMK1G1.04612232
38PRKCG1.03802657
39GRK11.00844267
40MAP3K120.99372606
41MYLK0.98576358
42PIK3CA0.97263394
43NUAK10.97215743
44ERN10.96342776
45PAK30.95374524
46MAP3K20.95265681
47CAMK10.94750580
48ACVR1B0.92081855
49MAP3K70.89960448
50CAMK2B0.85866427
51PKN10.84916545
52PRKCE0.84696033
53CSNK1A10.83214344
54TYRO30.82873447
55MARK20.82316460
56CDK50.79596904
57OXSR10.79073869
58CAMK2A0.77863628
59PRKCH0.74762623
60LMTK20.74659373
61GSK3A0.73093065
62CSNK1D0.72176125
63DYRK1A0.68717351
64CAMK40.67804311
65PDGFRB0.67679815
66PRKAA10.67333716
67MINK10.67065505
68MAPK100.66454600
69NLK0.65798679
70STK390.62316409
71CSNK1E0.62147140
72PTK2B0.59947227
73ROCK10.59673716
74WNK10.58933423
75CAMK2D0.57809919
76DAPK10.57787872
77RPS6KA30.57278530
78BMPR1B0.56657625
79STK380.55922703
80MAP2K40.54526072
81PRKCZ0.53021998
82CSNK1A1L0.52489154
83HIPK20.52297643
84PRKG10.51035971
85PAK60.50496315
86PLK20.49106824
87STK110.48383115
88EPHA30.46964547
89ADRBK10.45501763
90ZAK0.45161395
91PRKACA0.43024020
92PDGFRA0.42708600
93FGFR30.42237556
94NEK60.41837624
95MAPK150.40795062
96DDR20.40252537
97NTRK10.40069995
98CAMK2G0.39089571
99PRKAA20.38060135
100ERBB20.36757464

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44336980
2Circadian rhythm_Homo sapiens_hsa047102.56288395
3Amphetamine addiction_Homo sapiens_hsa050312.53466488
4Circadian entrainment_Homo sapiens_hsa047132.47154148
5Cocaine addiction_Homo sapiens_hsa050302.44815159
6Insulin secretion_Homo sapiens_hsa049112.35804936
7Glutamatergic synapse_Homo sapiens_hsa047242.35227045
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09878491
9GABAergic synapse_Homo sapiens_hsa047272.07879129
10Nitrogen metabolism_Homo sapiens_hsa009101.94697217
11Dopaminergic synapse_Homo sapiens_hsa047281.91982926
12Morphine addiction_Homo sapiens_hsa050321.87574618
13Synaptic vesicle cycle_Homo sapiens_hsa047211.86581006
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76263412
15Histidine metabolism_Homo sapiens_hsa003401.75575515
16Taste transduction_Homo sapiens_hsa047421.69087329
17Serotonergic synapse_Homo sapiens_hsa047261.66876983
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66797286
19Salivary secretion_Homo sapiens_hsa049701.59523910
20Renin secretion_Homo sapiens_hsa049241.51323657
21Gastric acid secretion_Homo sapiens_hsa049711.51227213
22Long-term potentiation_Homo sapiens_hsa047201.48417438
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47703440
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47309265
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.45255102
26Type II diabetes mellitus_Homo sapiens_hsa049301.40337344
27Calcium signaling pathway_Homo sapiens_hsa040201.37472956
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36882167
29Cholinergic synapse_Homo sapiens_hsa047251.35538778
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34359895
31Long-term depression_Homo sapiens_hsa047301.33985237
32beta-Alanine metabolism_Homo sapiens_hsa004101.30683140
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29055214
34Ovarian steroidogenesis_Homo sapiens_hsa049131.26230379
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.24740812
36cAMP signaling pathway_Homo sapiens_hsa040241.24479551
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20615338
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17496161
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14494602
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14202311
41ABC transporters_Homo sapiens_hsa020101.09855502
42Pancreatic secretion_Homo sapiens_hsa049721.09020922
43Butanoate metabolism_Homo sapiens_hsa006501.08108260
44Bile secretion_Homo sapiens_hsa049761.06592789
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04331552
46Dorso-ventral axis formation_Homo sapiens_hsa043201.02912441
47Phototransduction_Homo sapiens_hsa047441.00048174
48Oxytocin signaling pathway_Homo sapiens_hsa049210.99808575
49Ether lipid metabolism_Homo sapiens_hsa005650.96764463
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95619849
51Tryptophan metabolism_Homo sapiens_hsa003800.95448482
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93191350
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89629999
54Fatty acid biosynthesis_Homo sapiens_hsa000610.88612224
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86696268
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85895344
57Dilated cardiomyopathy_Homo sapiens_hsa054140.85873853
58Linoleic acid metabolism_Homo sapiens_hsa005910.82448052
59Thyroid hormone synthesis_Homo sapiens_hsa049180.81250813
60Olfactory transduction_Homo sapiens_hsa047400.79838430
61Glycerolipid metabolism_Homo sapiens_hsa005610.79635409
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79100323
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.78826742
64Estrogen signaling pathway_Homo sapiens_hsa049150.75197444
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73404323
66Ras signaling pathway_Homo sapiens_hsa040140.71833492
67Gap junction_Homo sapiens_hsa045400.70787212
68GnRH signaling pathway_Homo sapiens_hsa049120.70042467
69Rap1 signaling pathway_Homo sapiens_hsa040150.69490751
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67150604
71Inositol phosphate metabolism_Homo sapiens_hsa005620.64868377
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64866229
73Axon guidance_Homo sapiens_hsa043600.64007297
74Mineral absorption_Homo sapiens_hsa049780.63780567
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.63332496
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61002151
77Tight junction_Homo sapiens_hsa045300.60339034
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.60306752
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58627241
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57827108
81Wnt signaling pathway_Homo sapiens_hsa043100.56624454
82Melanoma_Homo sapiens_hsa052180.55786808
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53985049
84ECM-receptor interaction_Homo sapiens_hsa045120.50836636
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48473148
86Choline metabolism in cancer_Homo sapiens_hsa052310.48412179
87Melanogenesis_Homo sapiens_hsa049160.45400734
88MAPK signaling pathway_Homo sapiens_hsa040100.45285194
89Arginine and proline metabolism_Homo sapiens_hsa003300.45051311
90Cardiac muscle contraction_Homo sapiens_hsa042600.43914268
91Protein digestion and absorption_Homo sapiens_hsa049740.43809722
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41211741
93ErbB signaling pathway_Homo sapiens_hsa040120.40917259
94Hippo signaling pathway_Homo sapiens_hsa043900.40708103
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40641463
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.40554516
97Hedgehog signaling pathway_Homo sapiens_hsa043400.40255013
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39109670
99Platelet activation_Homo sapiens_hsa046110.37085384
100TGF-beta signaling pathway_Homo sapiens_hsa043500.36099933

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