HUWE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.38860398
2nuclear pore complex assembly (GO:0051292)4.95026391
3cytoplasmic mRNA processing body assembly (GO:0033962)4.73346740
4mitotic sister chromatid cohesion (GO:0007064)4.72764292
5nuclear pore organization (GO:0006999)4.50803822
6regulation of RNA export from nucleus (GO:0046831)4.17081968
7regulation of histone H3-K27 methylation (GO:0061085)4.11912920
8glucocorticoid receptor signaling pathway (GO:0042921)3.78675554
9NLS-bearing protein import into nucleus (GO:0006607)3.69927834
10negative regulation of histone methylation (GO:0031061)3.69197800
11regulation of nucleobase-containing compound transport (GO:0032239)3.59407077
12histone H3-K4 trimethylation (GO:0080182)3.58222895
13stress granule assembly (GO:0034063)3.55775904
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.51520521
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.51520521
16regulation of translation, ncRNA-mediated (GO:0045974)3.51520521
17pore complex assembly (GO:0046931)3.50747480
18COPI coating of Golgi vesicle (GO:0048205)3.49482444
19Golgi transport vesicle coating (GO:0048200)3.49482444
20histone H3-K4 methylation (GO:0051568)3.41438623
21cell-substrate adherens junction assembly (GO:0007045)3.41222557
22focal adhesion assembly (GO:0048041)3.41222557
23positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.34510880
24peptidyl-lysine dimethylation (GO:0018027)3.21218423
25establishment of nucleus localization (GO:0040023)3.17661721
26corticosteroid receptor signaling pathway (GO:0031958)3.14960640
27cell-substrate junction assembly (GO:0007044)3.14736284
28protein export from nucleus (GO:0006611)3.12470926
29insulin-like growth factor receptor signaling pathway (GO:0048009)3.11229026
30histone H3-K36 demethylation (GO:0070544)3.10917151
31hippo signaling (GO:0035329)3.09415121
32mitotic sister chromatid segregation (GO:0000070)3.08484431
33negative regulation of DNA repair (GO:0045738)3.02416443
34histone H3-K9 demethylation (GO:0033169)3.02141072
35histone lysine methylation (GO:0034968)3.01376402
36peptidyl-lysine trimethylation (GO:0018023)2.96866539
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93180723
38cytoskeletal anchoring at plasma membrane (GO:0007016)2.92403980
39embryonic camera-type eye morphogenesis (GO:0048596)2.91981276
40heterochromatin organization (GO:0070828)2.90136758
41histone H4-K16 acetylation (GO:0043984)2.88962473
42regulation of histone H3-K9 methylation (GO:0051570)2.84629942
43mitotic nuclear envelope disassembly (GO:0007077)2.83650543
44nuclear envelope disassembly (GO:0051081)2.82661029
45membrane disassembly (GO:0030397)2.82661029
46regulation of glucose import in response to insulin stimulus (GO:2001273)2.81734081
47regulation of NFAT protein import into nucleus (GO:0051532)2.81617293
48hemidesmosome assembly (GO:0031581)2.81491375
49protein localization to microtubule (GO:0035372)2.80671592
50positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.80524261
51regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.80524261
52histone lysine demethylation (GO:0070076)2.79753533
53activation of Rac GTPase activity (GO:0032863)2.78848655
54paraxial mesoderm development (GO:0048339)2.76503236
55regulation of DNA endoreduplication (GO:0032875)2.76464251
56regulation of protein polyubiquitination (GO:1902914)2.75335699
57regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74658699
58embryonic eye morphogenesis (GO:0048048)2.73863576
59cellular protein complex localization (GO:0034629)2.73855295
60response to epidermal growth factor (GO:0070849)2.73187237
61desmosome organization (GO:0002934)2.72968271
62protein-DNA complex disassembly (GO:0032986)2.71359138
63nucleosome disassembly (GO:0006337)2.71359138
64cellular response to epidermal growth factor stimulus (GO:0071364)2.70225403
65regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.69769077
66histone H3-K9 methylation (GO:0051567)2.69326545
67heart morphogenesis (GO:0003007)2.68143735
68nucleus localization (GO:0051647)2.66266498
69embryonic process involved in female pregnancy (GO:0060136)2.66139351
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64377309
71positive regulation of gene expression, epigenetic (GO:0045815)2.63880705
72chromosome condensation (GO:0030261)2.63235113
73regulation of translational fidelity (GO:0006450)2.61586176
74histone methylation (GO:0016571)2.59267916
75positive regulation of histone deacetylation (GO:0031065)2.58069201
76histone demethylation (GO:0016577)2.57704155
77regulation of sister chromatid cohesion (GO:0007063)2.57378412
78negative regulation of histone modification (GO:0031057)2.57296306
79DNA conformation change (GO:0071103)2.57262249
80gastrulation with mouth forming second (GO:0001702)2.57215004
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57044228
82peptidyl-lysine methylation (GO:0018022)2.56423337
83protein complex localization (GO:0031503)2.55964642
84head development (GO:0060322)2.55728802
85regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.55418042
86nuclear envelope organization (GO:0006998)2.54500793
87regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53618962
88positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53618962
89histone H3-K9 modification (GO:0061647)2.51144828
90gene silencing (GO:0016458)2.50738788
91negative regulation of cell size (GO:0045792)2.50479724
92DNA synthesis involved in DNA repair (GO:0000731)2.50392843
93RNA stabilization (GO:0043489)2.49102705
94mRNA stabilization (GO:0048255)2.49102705
95establishment of spindle localization (GO:0051293)2.48972595
96morphogenesis of an epithelial sheet (GO:0002011)2.48963511
97histone H4-K5 acetylation (GO:0043981)2.48545421
98histone H4-K8 acetylation (GO:0043982)2.48545421
99layer formation in cerebral cortex (GO:0021819)2.46969444
100DNA replication initiation (GO:0006270)2.45216925
101negative regulation of chromatin modification (GO:1903309)2.45090355
102chromatin silencing (GO:0006342)2.45047706
103gene silencing by RNA (GO:0031047)2.44942949
104establishment of spindle orientation (GO:0051294)2.44475847
105regulation of histone methylation (GO:0031060)2.43875028
106positive regulation of RNA splicing (GO:0033120)2.43370750
107peptidyl-threonine phosphorylation (GO:0018107)2.42556014
108mitotic chromosome condensation (GO:0007076)2.41775540
109trophectodermal cell differentiation (GO:0001829)2.40484544
110neural tube development (GO:0021915)2.40422875
111DNA topological change (GO:0006265)2.40320900
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40154041
113histone H4-K12 acetylation (GO:0043983)2.39791859
114chromatin assembly (GO:0031497)2.38836748
115regulation of mitotic spindle organization (GO:0060236)2.38635631
116DNA duplex unwinding (GO:0032508)2.37514884
117retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37507652
118DNA geometric change (GO:0032392)2.36539570
119cerebellar Purkinje cell differentiation (GO:0021702)2.36377332
120histone H2A monoubiquitination (GO:0035518)2.35593898
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.35417449
122interkinetic nuclear migration (GO:0022027)2.35189944
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35188659
124adherens junction assembly (GO:0034333)2.34859145
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34654175
126semaphorin-plexin signaling pathway (GO:0071526)2.33946666
127DNA packaging (GO:0006323)2.33903466
128dosage compensation (GO:0007549)2.32207250
129negative regulation of fatty acid transport (GO:2000192)2.31734541
130positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.31670007
131peptidyl-threonine modification (GO:0018210)2.31615607
132sister chromatid segregation (GO:0000819)2.31599664
133epithelial cell-cell adhesion (GO:0090136)2.31069607
134positive regulation of SMAD protein import into nucleus (GO:0060391)2.29918659
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.29908610
136intracellular estrogen receptor signaling pathway (GO:0030520)2.29872070
137protein localization to chromosome, centromeric region (GO:0071459)2.29559948
138DNA unwinding involved in DNA replication (GO:0006268)2.29429994
139polarized epithelial cell differentiation (GO:0030859)2.29273748
140COPII vesicle coating (GO:0048208)2.29170464
141regulation of gene silencing by RNA (GO:0060966)2.29118653
142regulation of posttranscriptional gene silencing (GO:0060147)2.29118653
143regulation of gene silencing by miRNA (GO:0060964)2.29118653
144neural tube closure (GO:0001843)2.29067933
145sister chromatid cohesion (GO:0007062)2.27711705
146protein demethylation (GO:0006482)2.27646971
147protein dealkylation (GO:0008214)2.27646971
148regulation of histone H3-K4 methylation (GO:0051569)2.27576477
149histone H4 acetylation (GO:0043967)2.27043471
150regulation of clathrin-mediated endocytosis (GO:2000369)2.26378547
151anterior/posterior axis specification, embryo (GO:0008595)2.25808738
152tube closure (GO:0060606)2.25502564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06690311
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.68206470
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.53362823
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.50152431
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.36478091
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28827901
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.06218055
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.66338990
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45285366
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36703503
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.29023322
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21418590
13* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.21177999
14AR_21909140_ChIP-Seq_LNCAP_Human2.17454388
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09884991
16MYC_22102868_ChIP-Seq_BL_Human2.08314393
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03254185
18* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.99132836
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96591535
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95268255
21CLOCK_20551151_ChIP-Seq_293T_Human1.93173617
22* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.88176160
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85025720
24KDM2B_26808549_Chip-Seq_DND41_Human1.83356788
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78405554
26PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74294584
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68088504
28ISL1_27105846_Chip-Seq_CPCs_Mouse1.66726451
29RACK7_27058665_Chip-Seq_MCF-7_Human1.66558159
30TP53_16413492_ChIP-PET_HCT116_Human1.63957903
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63545211
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.62138923
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.61377543
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.61309654
35CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.59973266
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.59468090
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58668400
38* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58430522
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54070076
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54037262
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53395075
42DROSHA_22980978_ChIP-Seq_HELA_Human1.51611298
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51211627
44VDR_21846776_ChIP-Seq_THP-1_Human1.49416681
45KDM2B_26808549_Chip-Seq_K562_Human1.49237712
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48810864
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48752398
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.48342795
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47356484
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46195169
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45351149
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43305612
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.43014887
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40978429
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38815827
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37141010
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.37025190
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36208226
59AHR_22903824_ChIP-Seq_MCF-7_Human1.35813780
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33402585
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32928932
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30644061
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30446538
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30291271
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30209562
66TBX3_20139965_ChIP-Seq_MESCs_Mouse1.29510951
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.28769940
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27527912
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.26843098
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26543356
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25120444
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.24679737
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24315475
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23101364
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23001614
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21763483
77EZH2_22144423_ChIP-Seq_EOC_Human1.20904308
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20650732
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20139106
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19820588
81* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19768679
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.19401214
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18594467
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18540719
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17840450
86* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17425579
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16378459
88ATF3_27146783_Chip-Seq_COLON_Human1.16204509
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16173490
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14955239
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14955239
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.14794292
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.14791392
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14378306
95GATA1_22025678_ChIP-Seq_K562_Human1.13933660
96* AR_19668381_ChIP-Seq_PC3_Human1.13243417
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12858721
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12333023
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11120960
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10939626
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09032037
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.08297686
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.08297686
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07928345
105LXR_22292898_ChIP-Seq_THP-1_Human1.07556831
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07400710
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07266680
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.06892346
109* E2F1_21310950_ChIP-Seq_MCF-7_Human1.06828192
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04549782
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04549782
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04549782
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03556143
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02892378
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02891440
116* STAT3_23295773_ChIP-Seq_U87_Human1.01056087
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.00148472
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99997974
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99921367
120BRD4_25478319_ChIP-Seq_HGPS_Human0.99410737
121CIITA_25753668_ChIP-Seq_RAJI_Human0.97664220
122NCOR1_26117541_ChIP-Seq_K562_Human0.97613323
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97505145
124AR_21572438_ChIP-Seq_LNCaP_Human0.97102543
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96979617
126CREB1_26743006_Chip-Seq_LNCaP_Human0.96609265
127CHD1_26751641_Chip-Seq_LNCaP_Human0.95910838
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95708244
129* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95591706
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95358699
131* NANOG_21062744_ChIP-ChIP_HESCs_Human0.95190725
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.94376124
133KDM5A_27292631_Chip-Seq_BREAST_Human0.93701098
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92436136
135GATA6_25053715_ChIP-Seq_YYC3_Human0.92105364
136* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92037216
137POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91781566
138* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88973750
139TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88768866
140TCF4_23295773_ChIP-Seq_U87_Human0.87908123
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.87872507
142* RUNX1_27514584_Chip-Seq_MCF-7_Human0.87286609
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86572043
144* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86081680
145TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85092949
146HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83862690
147ZNF263_19887448_ChIP-Seq_K562_Human0.83201210
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82117461
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81059295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.17464512
2MP0005076_abnormal_cell_differentiation3.26078152
3MP0010352_gastrointestinal_tract_polyps2.88976627
4MP0003705_abnormal_hypodermis_morpholog2.88805799
5MP0003121_genomic_imprinting2.43169572
6MP0005409_darkened_coat_color2.38999595
7MP0003787_abnormal_imprinting2.31474897
8MP0000537_abnormal_urethra_morphology2.22746609
9MP0010234_abnormal_vibrissa_follicle2.22643257
10MP0003890_abnormal_embryonic-extraembry2.11448068
11MP0005451_abnormal_body_composition1.95587270
12MP0004197_abnormal_fetal_growth/weight/1.86689471
13MP0010307_abnormal_tumor_latency1.85144418
14MP0003300_gastrointestinal_ulcer1.83335907
15MP0003123_paternal_imprinting1.82775667
16MP0005187_abnormal_penis_morphology1.82076604
17MP0000733_abnormal_muscle_development1.81436896
18* MP0002084_abnormal_developmental_patter1.79339544
19MP0008877_abnormal_DNA_methylation1.74665227
20MP0003045_fibrosis1.74518827
21MP0009703_decreased_birth_body1.73337843
22MP0008961_abnormal_basal_metabolism1.72574784
23MP0009780_abnormal_chondrocyte_physiolo1.69939403
24MP0008057_abnormal_DNA_replication1.67713948
25MP0004957_abnormal_blastocyst_morpholog1.66742347
26MP0005623_abnormal_meninges_morphology1.65156093
27MP0003122_maternal_imprinting1.64027088
28MP0000428_abnormal_craniofacial_morphol1.62376537
29MP0003935_abnormal_craniofacial_develop1.60854914
30MP0001299_abnormal_eye_distance/1.60434009
31MP0003941_abnormal_skin_development1.59729886
32MP0008438_abnormal_cutaneous_collagen1.58207887
33MP0010678_abnormal_skin_adnexa1.57147343
34MP0001661_extended_life_span1.55810491
35MP0003453_abnormal_keratinocyte_physiol1.52621524
36MP0001849_ear_inflammation1.50810387
37MP0001730_embryonic_growth_arrest1.50799806
38MP0004272_abnormal_basement_membrane1.49440078
39MP0004233_abnormal_muscle_weight1.48294620
40* MP0002085_abnormal_embryonic_tissue1.46130534
41* MP0001672_abnormal_embryogenesis/_devel1.45783192
42* MP0005380_embryogenesis_phenotype1.45783192
43MP0003283_abnormal_digestive_organ1.45532540
44MP0009672_abnormal_birth_weight1.45341817
45* MP0003984_embryonic_growth_retardation1.44608582
46MP0003937_abnormal_limbs/digits/tail_de1.44496026
47MP0002086_abnormal_extraembryonic_tissu1.44220738
48* MP0002088_abnormal_embryonic_growth/wei1.43990887
49MP0003111_abnormal_nucleus_morphology1.43878361
50MP0003693_abnormal_embryo_hatching1.43581121
51MP0009053_abnormal_anal_canal1.43378191
52MP0003115_abnormal_respiratory_system1.39834394
53MP0004859_abnormal_synaptic_plasticity1.39289695
54MP0004185_abnormal_adipocyte_glucose1.38719619
55MP0001348_abnormal_lacrimal_gland1.36362156
56MP0010094_abnormal_chromosome_stability1.35420135
57MP0002796_impaired_skin_barrier1.33884650
58MP0001293_anophthalmia1.33158489
59MP0000350_abnormal_cell_proliferation1.32871942
60MP0001346_abnormal_lacrimal_gland1.29817930
61MP0003119_abnormal_digestive_system1.28816706
62MP0000383_abnormal_hair_follicle1.28486189
63MP0002925_abnormal_cardiovascular_devel1.28061003
64MP0003385_abnormal_body_wall1.26807291
65MP0003091_abnormal_cell_migration1.24831357
66MP0005248_abnormal_Harderian_gland1.23666441
67MP0001697_abnormal_embryo_size1.22574687
68* MP0003861_abnormal_nervous_system1.21582917
69MP0002697_abnormal_eye_size1.21399939
70MP0000579_abnormal_nail_morphology1.20996660
71MP0005621_abnormal_cell_physiology1.19969534
72MP0004858_abnormal_nervous_system1.17114566
73MP0002060_abnormal_skin_morphology1.15686774
74MP0003567_abnormal_fetal_cardiomyocyte1.14093978
75MP0003566_abnormal_cell_adhesion1.13281545
76MP0004885_abnormal_endolymph1.13177012
77MP0000003_abnormal_adipose_tissue1.12280243
78MP0005257_abnormal_intraocular_pressure1.12257663
79* MP0000432_abnormal_head_morphology1.12216871
80MP0003755_abnormal_palate_morphology1.11959212
81MP0010030_abnormal_orbit_morphology1.09627474
82MP0000534_abnormal_ureter_morphology1.09194676
83MP0003077_abnormal_cell_cycle1.09057873
84MP0002092_abnormal_eye_morphology1.07211099
85MP0010630_abnormal_cardiac_muscle1.06020415
86MP0002009_preneoplasia1.05988628
87MP0008932_abnormal_embryonic_tissue1.04194556
88MP0000751_myopathy1.03842656
89MP0003763_abnormal_thymus_physiology1.02696363
90MP0009278_abnormal_bone_marrow1.01462312
91MP0000759_abnormal_skeletal_muscle0.99452125
92MP0000778_abnormal_nervous_system0.99300039
93MP0005375_adipose_tissue_phenotype0.98660917
94MP0004264_abnormal_extraembryonic_tissu0.96588038
95MP0005501_abnormal_skin_physiology0.95790253
96MP0005666_abnormal_adipose_tissue0.95321070
97* MP0002080_prenatal_lethality0.93547481
98MP0004808_abnormal_hematopoietic_stem0.92918830
99MP0002116_abnormal_craniofacial_bone0.92831419
100MP0002396_abnormal_hematopoietic_system0.92731844
101MP0002006_tumorigenesis0.92619398
102MP0000627_abnormal_mammary_gland0.92117612
103MP0001915_intracranial_hemorrhage0.91746782
104* MP0000266_abnormal_heart_morphology0.91612036
105MP0002249_abnormal_larynx_morphology0.90903207
106MP0002108_abnormal_muscle_morphology0.90092179
107MP0002269_muscular_atrophy0.90082025
108MP0008770_decreased_survivor_rate0.89723862
109MP0005023_abnormal_wound_healing0.89448130
110MP0008007_abnormal_cellular_replicative0.89086444
111MP0001873_stomach_inflammation0.88803897
112MP0005275_abnormal_skin_tensile0.88206345
113MP0006138_congestive_heart_failure0.87742956
114MP0001784_abnormal_fluid_regulation0.87467588
115MP0000377_abnormal_hair_follicle0.87136172
116MP0003950_abnormal_plasma_membrane0.85922276
117MP0001216_abnormal_epidermal_layer0.84444763
118MP0005384_cellular_phenotype0.84133300
119MP0002877_abnormal_melanocyte_morpholog0.83581031
120MP0000747_muscle_weakness0.83357280
121MP0002166_altered_tumor_susceptibility0.80930061
122MP0004087_abnormal_muscle_fiber0.79858961
123* MP0002152_abnormal_brain_morphology0.79542070
124MP0002098_abnormal_vibrissa_morphology0.78659299
125MP0002233_abnormal_nose_morphology0.78608063
126* MP0002081_perinatal_lethality0.78504851
127MP0003942_abnormal_urinary_system0.77427851
128MP0000462_abnormal_digestive_system0.76050298
129MP0002896_abnormal_bone_mineralization0.73036372
130MP0002089_abnormal_postnatal_growth/wei0.71730767
131MP0005367_renal/urinary_system_phenotyp0.70908168
132MP0000516_abnormal_urinary_system0.70908168
133MP0002111_abnormal_tail_morphology0.70653661
134MP0002234_abnormal_pharynx_morphology0.70168171
135MP0002168_other_aberrant_phenotype0.70123116
136MP0003632_abnormal_nervous_system0.69741722
137MP0001286_abnormal_eye_development0.69193497

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.63894516
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.63894516
3Volvulus (HP:0002580)3.36368166
4Abnormality of the fingertips (HP:0001211)3.32249669
5Astrocytoma (HP:0009592)3.03156499
6Abnormality of the astrocytes (HP:0100707)3.03156499
7Broad face (HP:0000283)2.87295439
8Trigonocephaly (HP:0000243)2.83310679
9Narrow palate (HP:0000189)2.83139515
10Long eyelashes (HP:0000527)2.75847800
11Hyperacusis (HP:0010780)2.73787062
12Abnormality of the 4th metacarpal (HP:0010012)2.71738112
13Shallow orbits (HP:0000586)2.69868394
14Urethral obstruction (HP:0000796)2.67745866
15Heterotopia (HP:0002282)2.67513134
16Ependymoma (HP:0002888)2.66533943
17Abnormality of the distal phalanx of the thumb (HP:0009617)2.64190969
18Obsessive-compulsive behavior (HP:0000722)2.58344687
19Increased nuchal translucency (HP:0010880)2.49315801
20Glioma (HP:0009733)2.43789403
21Ulnar bowing (HP:0003031)2.40938243
22Asymmetry of the thorax (HP:0001555)2.39179948
23Renovascular hypertension (HP:0100817)2.38244861
24Neoplasm of the oral cavity (HP:0100649)2.37429481
25Flat acetabular roof (HP:0003180)2.35103639
26Elfin facies (HP:0004428)2.34700500
27Cerebral aneurysm (HP:0004944)2.27125456
28Broad thumb (HP:0011304)2.25518584
29* Macroorchidism (HP:0000053)2.25141159
30Sparse lateral eyebrow (HP:0005338)2.21909096
31Advanced eruption of teeth (HP:0006288)2.21729011
32Supernumerary ribs (HP:0005815)2.21011100
33Dislocated radial head (HP:0003083)2.18760127
34Absent frontal sinuses (HP:0002688)2.18265844
35Truncal obesity (HP:0001956)2.17351167
36Anal stenosis (HP:0002025)2.17012320
37Abnormality of the nasal septum (HP:0000419)2.16740078
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.14792070
39Osteolytic defects of the hand bones (HP:0009699)2.14792070
40Renal duplication (HP:0000075)2.14709483
41Aqueductal stenosis (HP:0002410)2.10180677
42Distal lower limb amyotrophy (HP:0008944)2.10008518
43Protrusio acetabuli (HP:0003179)2.09803849
44Relative macrocephaly (HP:0004482)2.08565052
45Overriding aorta (HP:0002623)2.05061682
46Deviation of the thumb (HP:0009603)2.03147705
47Proximal placement of thumb (HP:0009623)2.02159022
48Obstructive sleep apnea (HP:0002870)2.01873733
49Pointed chin (HP:0000307)2.01201414
50Abnormality of the radial head (HP:0003995)1.99926280
51Papillary thyroid carcinoma (HP:0002895)1.98927245
52Abnormality of oral frenula (HP:0000190)1.98885262
53Medulloblastoma (HP:0002885)1.98727849
54Persistence of primary teeth (HP:0006335)1.98341142
55High anterior hairline (HP:0009890)1.96951704
56Dysmetric saccades (HP:0000641)1.96657395
57Spinal cord lesions (HP:0100561)1.96297296
58Syringomyelia (HP:0003396)1.96297296
59Midline defect of the nose (HP:0004122)1.95992185
60Skull defect (HP:0001362)1.95733510
61Insidious onset (HP:0003587)1.95329467
62Termporal pattern (HP:0011008)1.95329467
63Increased connective tissue (HP:0009025)1.94837938
64Genetic anticipation (HP:0003743)1.94760521
65Disproportionate tall stature (HP:0001519)1.94101422
66Prominent nose (HP:0000448)1.93458328
67Overgrowth (HP:0001548)1.92997964
68Right ventricular cardiomyopathy (HP:0011663)1.92967263
69Germ cell neoplasia (HP:0100728)1.92760781
70Patellar dislocation (HP:0002999)1.90463826
71Hypoplastic labia majora (HP:0000059)1.89932857
72Abnormality of the calcaneus (HP:0008364)1.89849238
73Smooth philtrum (HP:0000319)1.88671854
74Chromsome breakage (HP:0040012)1.88657102
75Bowel diverticulosis (HP:0005222)1.87682653
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86684624
77Hypoplasia of the maxilla (HP:0000327)1.86549610
78Missing ribs (HP:0000921)1.86433320
79Abnormality of the labia minora (HP:0012880)1.86108625
80Pseudobulbar signs (HP:0002200)1.85789945
81Subacute progressive viral hepatitis (HP:0006572)1.85065912
82Abnormality of the diencephalon (HP:0010662)1.84523400
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83222120
84Short nail (HP:0001799)1.82834573
85Neonatal hypoglycemia (HP:0001998)1.82735370
86Septate vagina (HP:0001153)1.82553577
87Sacral dimple (HP:0000960)1.81511766
88Supernumerary bones of the axial skeleton (HP:0009144)1.80093914
89Lip pit (HP:0100267)1.79613615
90Abnormality of the phalanges of the hallux (HP:0010057)1.78982286
91Gastrointestinal carcinoma (HP:0002672)1.78682466
92Malignant gastrointestinal tract tumors (HP:0006749)1.78682466
93Overlapping toe (HP:0001845)1.78611448
94Neoplasm of striated muscle (HP:0009728)1.78356137
95Lower limb amyotrophy (HP:0007210)1.77996460
96Neoplasm of the heart (HP:0100544)1.77938168
97Low anterior hairline (HP:0000294)1.77359842
98Broad phalanges of the hand (HP:0009768)1.77251931
99Selective tooth agenesis (HP:0001592)1.76489207
100Insomnia (HP:0100785)1.75692861
101Attention deficit hyperactivity disorder (HP:0007018)1.75213060
102Ankyloglossia (HP:0010296)1.74850981
103Enlarged penis (HP:0000040)1.74796906
104Vertebral arch anomaly (HP:0008438)1.74621345
105Long palpebral fissure (HP:0000637)1.72949085
106Large earlobe (HP:0009748)1.72715740
107Broad palm (HP:0001169)1.72588152
108Precocious puberty (HP:0000826)1.71613638
109Thick eyebrow (HP:0000574)1.70627266
110Ectopic kidney (HP:0000086)1.69966267
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.69886759
112Natal tooth (HP:0000695)1.68992484
113Sandal gap (HP:0001852)1.68687073
114Hypoplastic ischia (HP:0003175)1.68509488
115Broad finger (HP:0001500)1.67959285
116Flat cornea (HP:0007720)1.66994061
117Urinary bladder sphincter dysfunction (HP:0002839)1.66839067
118Deep philtrum (HP:0002002)1.66684081
119Abnormality of the labia majora (HP:0012881)1.66663383
120Arterial tortuosity (HP:0005116)1.66422078
121Skin tags (HP:0010609)1.66218218
122Cubitus valgus (HP:0002967)1.65818805
123Transitional cell carcinoma of the bladder (HP:0006740)1.65456369
124Fibrous tissue neoplasm (HP:0012316)1.64511474
125Arnold-Chiari malformation (HP:0002308)1.64508054
126Abnormality of the lower motor neuron (HP:0002366)1.64007497
127Aneurysm (HP:0002617)1.63399642
128Rectal prolapse (HP:0002035)1.62880156
129Premature rupture of membranes (HP:0001788)1.62579172
130Difficulty running (HP:0009046)1.62403929
131Mitral valve prolapse (HP:0001634)1.62192371
132Cutis marmorata (HP:0000965)1.61545404
133Aortic aneurysm (HP:0004942)1.58874003
134Fibroma (HP:0010614)1.58869553
135Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58279693
136Abnormality of chromosome segregation (HP:0002916)1.58181187
137Abnormal number of incisors (HP:0011064)1.58091253
138Wormian bones (HP:0002645)1.57515133
139Hypopigmentation of the fundus (HP:0007894)1.57401532
140Oligodontia (HP:0000677)1.57176813
141Broad phalanx (HP:0006009)1.56544139
142Abnormality of the epiphyses of the hand (HP:0005924)1.56393460
143Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56171994
144Biliary tract neoplasm (HP:0100574)1.55550076
145Lymphangioma (HP:0100764)1.54966015
146Facial hemangioma (HP:0000329)1.54961685
147Acute myeloid leukemia (HP:0004808)1.54915307
148Leiomyosarcoma (HP:0100243)1.54878611
14911 pairs of ribs (HP:0000878)1.54265588
150Abnormal ossification of hand bones (HP:0005921)1.52983182
151Abnormality of the salivary glands (HP:0010286)1.52215697
152Mitral regurgitation (HP:0001653)1.52031182
153Bronchomalacia (HP:0002780)1.51422500
154Dental malocclusion (HP:0000689)1.51177406
155Deep palmar crease (HP:0006191)1.49196868
156Open mouth (HP:0000194)1.47987881
157Subaortic stenosis (HP:0001682)1.46128010
158Abnormality of the left ventricular outflow tract (HP:0011103)1.46128010
159Abnormality of the humeroradial joint (HP:0100744)1.45552465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.76936358
2SMG13.32031242
3CAMK1G3.13851673
4CAMK1D3.07093786
5BRD42.90362448
6LATS12.70643501
7PRPF4B2.50690391
8EEF2K2.22739487
9CDC72.04478917
10MAP3K101.91596643
11FGFR21.90075267
12ICK1.83602948
13MTOR1.79293620
14PKN21.77210752
15RIPK11.76034512
16PNCK1.72374467
17MST1R1.68283943
18SIK11.65168528
19PDGFRA1.64566772
20TTN1.56972408
21ALK1.54468219
22SIK21.47788597
23TRIB31.43594593
24DMPK1.41380092
25SCYL21.32488956
26WNK11.28233280
27STK31.26864452
28FGFR11.24527581
29MAP3K91.23300073
30PTK61.21886291
31IRAK31.18263969
32CDK61.17527378
33PDGFRB1.16854983
34FGFR31.14779068
35TYRO31.14023121
36EPHA21.12262304
37NEK21.11674726
38MAP3K41.06953518
39MAP3K71.06025402
40SGK31.03929921
41CDC42BPA1.03836076
42CDK91.02903293
43AKT31.01984316
44NTRK31.01181053
45CHEK10.99385004
46RET0.98341494
47LATS20.97719479
48PRKD30.96211799
49KSR10.93778542
50MARK20.90926824
51CSNK1A1L0.90376478
52CSNK1D0.89285675
53CDK40.85691112
54MAP3K130.84461818
55MAPK110.82866378
56PAK60.81310040
57BMX0.80732654
58* ATM0.80028156
59TRPM70.78909833
60MELK0.78637259
61CDK20.77771817
62NEK90.74693565
63NTRK10.74445213
64NTRK20.72845811
65PAK20.72357161
66CSNK1E0.71686624
67TAOK10.70389848
68STK110.70092388
69TTK0.69724556
70DDR20.69541447
71MAPK100.68426248
72PRKCH0.68205652
73PRKDC0.67681990
74TSSK60.67603610
75PTK20.67084143
76MAPK140.66806323
77CDK10.66580295
78STK380.66125190
79MAP3K20.66093224
80GSK3B0.65550087
81ERBB20.65014096
82SGK10.64532458
83* ATR0.64061342
84SGK20.62790161
85RPS6KA20.60811711
86MARK10.58758967
87MAPK80.56320295
88PAK40.55919419
89CAMK40.55592059
90MKNK20.54158589
91MAP3K140.52553026
92TAF10.52466331
93MAPK10.50551978
94FGFR40.50503588
95CHEK20.48629755
96EPHA30.48473713
97RPS6KB10.48061530
98RPS6KB20.47984072
99RPS6KA30.47917110
100EPHB10.47605301
101MET0.46493283
102JAK10.45849777
103SRPK10.45741031
104NEK60.45519135
105KSR20.45472485
106AURKB0.44486306
107STK100.43904129
108PRKAA10.43367121
109CDK80.42755253
110FER0.41901109
111CLK10.41741201
112AKT10.41283766
113INSRR0.40893288
114CDK70.40823160
115STK40.40532877
116HIPK20.40015004
117CHUK0.39866461
118CSNK1G20.39601019
119PRKAA20.39071755
120EIF2AK10.38633773
121PAK30.38239083
122SGK2230.37857437
123SGK4940.37857437
124MKNK10.37628210
125NEK10.36734900
126FRK0.36283992
127AKT20.36018788
128ERN10.35993790
129MAP3K80.35718874
130RPS6KL10.35336010
131RPS6KC10.35336010
132LMTK20.35035783

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.29983903
2mTOR signaling pathway_Homo sapiens_hsa041501.72765031
3Dorso-ventral axis formation_Homo sapiens_hsa043201.71372998
4Adherens junction_Homo sapiens_hsa045201.68082783
5Thyroid hormone signaling pathway_Homo sapiens_hsa049191.59166551
6Type II diabetes mellitus_Homo sapiens_hsa049301.58517258
7MicroRNAs in cancer_Homo sapiens_hsa052061.56004631
8Basal cell carcinoma_Homo sapiens_hsa052171.53449101
9Nitrogen metabolism_Homo sapiens_hsa009101.45771682
10Chronic myeloid leukemia_Homo sapiens_hsa052201.43220583
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42074039
12Endometrial cancer_Homo sapiens_hsa052131.41898477
13mRNA surveillance pathway_Homo sapiens_hsa030151.36031244
14Bladder cancer_Homo sapiens_hsa052191.35439499
15Glioma_Homo sapiens_hsa052141.34182503
16Proteoglycans in cancer_Homo sapiens_hsa052051.31303236
17Hippo signaling pathway_Homo sapiens_hsa043901.30889341
18Colorectal cancer_Homo sapiens_hsa052101.29540681
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27488447
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21927172
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21745584
22DNA replication_Homo sapiens_hsa030301.21110066
23Long-term potentiation_Homo sapiens_hsa047201.20711378
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19676591
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18987102
26Notch signaling pathway_Homo sapiens_hsa043301.18230220
27Estrogen signaling pathway_Homo sapiens_hsa049151.16562647
28Non-small cell lung cancer_Homo sapiens_hsa052231.15066843
29Wnt signaling pathway_Homo sapiens_hsa043101.14743037
30ErbB signaling pathway_Homo sapiens_hsa040121.13841432
31Hedgehog signaling pathway_Homo sapiens_hsa043401.12338805
32Focal adhesion_Homo sapiens_hsa045101.12081939
33Axon guidance_Homo sapiens_hsa043601.11913213
34Small cell lung cancer_Homo sapiens_hsa052221.11473462
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.11324632
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10889169
37Renal cell carcinoma_Homo sapiens_hsa052111.10799018
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10645905
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10585138
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10388874
41Prostate cancer_Homo sapiens_hsa052151.09148280
42Non-homologous end-joining_Homo sapiens_hsa034501.07703089
43* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03945237
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03607942
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01638529
46Viral myocarditis_Homo sapiens_hsa054161.00786068
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00608205
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00604092
49Dilated cardiomyopathy_Homo sapiens_hsa054141.00188991
50Oocyte meiosis_Homo sapiens_hsa041140.99926818
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.99466418
52Insulin resistance_Homo sapiens_hsa049310.99137331
53Pancreatic cancer_Homo sapiens_hsa052120.96892132
54Hepatitis B_Homo sapiens_hsa051610.95785666
55Melanogenesis_Homo sapiens_hsa049160.95581282
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94140226
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93850907
58TGF-beta signaling pathway_Homo sapiens_hsa043500.93590150
59GnRH signaling pathway_Homo sapiens_hsa049120.92854639
60Prion diseases_Homo sapiens_hsa050200.91360593
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91218207
62Insulin signaling pathway_Homo sapiens_hsa049100.90928936
63Tight junction_Homo sapiens_hsa045300.90779209
64AMPK signaling pathway_Homo sapiens_hsa041520.90762493
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.89881420
66Choline metabolism in cancer_Homo sapiens_hsa052310.89446791
67HTLV-I infection_Homo sapiens_hsa051660.89321944
68Cell cycle_Homo sapiens_hsa041100.86604938
69FoxO signaling pathway_Homo sapiens_hsa040680.86479545
70Inositol phosphate metabolism_Homo sapiens_hsa005620.86272999
71Pathways in cancer_Homo sapiens_hsa052000.86005919
72Oxytocin signaling pathway_Homo sapiens_hsa049210.85749166
73Rap1 signaling pathway_Homo sapiens_hsa040150.85419833
74Renin secretion_Homo sapiens_hsa049240.84724976
75Gastric acid secretion_Homo sapiens_hsa049710.84152173
76MAPK signaling pathway_Homo sapiens_hsa040100.83880747
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83761401
78ECM-receptor interaction_Homo sapiens_hsa045120.83577273
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83118157
80Gap junction_Homo sapiens_hsa045400.82453489
81Circadian entrainment_Homo sapiens_hsa047130.81700427
82cAMP signaling pathway_Homo sapiens_hsa040240.81267818
83HIF-1 signaling pathway_Homo sapiens_hsa040660.80766168
84Glucagon signaling pathway_Homo sapiens_hsa049220.80246224
85Viral carcinogenesis_Homo sapiens_hsa052030.80190183
86VEGF signaling pathway_Homo sapiens_hsa043700.77825859
87Salivary secretion_Homo sapiens_hsa049700.77629297
88T cell receptor signaling pathway_Homo sapiens_hsa046600.76689654
89Insulin secretion_Homo sapiens_hsa049110.75913778
90Dopaminergic synapse_Homo sapiens_hsa047280.75795480
91Amoebiasis_Homo sapiens_hsa051460.75650719
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75512024
93Acute myeloid leukemia_Homo sapiens_hsa052210.75122376
94Hepatitis C_Homo sapiens_hsa051600.73361540
95Glutamatergic synapse_Homo sapiens_hsa047240.73235018
96Biosynthesis of amino acids_Homo sapiens_hsa012300.72290017
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72235529
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72223460
99Cholinergic synapse_Homo sapiens_hsa047250.72045487
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69998904
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69752677
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.69130836
103Pentose phosphate pathway_Homo sapiens_hsa000300.68594073
104B cell receptor signaling pathway_Homo sapiens_hsa046620.68486310
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68421723
106RNA transport_Homo sapiens_hsa030130.68257368
107Platelet activation_Homo sapiens_hsa046110.67784138
108Prolactin signaling pathway_Homo sapiens_hsa049170.66362517
109Thyroid hormone synthesis_Homo sapiens_hsa049180.65612272
110Fatty acid biosynthesis_Homo sapiens_hsa000610.65419896
111Long-term depression_Homo sapiens_hsa047300.64464849
112Spliceosome_Homo sapiens_hsa030400.62959489
113Melanoma_Homo sapiens_hsa052180.62920667
114Apoptosis_Homo sapiens_hsa042100.62558783
115Thyroid cancer_Homo sapiens_hsa052160.61564242
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.60468053
117Morphine addiction_Homo sapiens_hsa050320.59765431
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56155310
119Measles_Homo sapiens_hsa051620.54322681
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.54159420
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52878710
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51469953
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50135737

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