HTRA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.23470840
2protoporphyrinogen IX metabolic process (GO:0046501)5.04864832
3ribosomal small subunit assembly (GO:0000028)4.68612728
4protoporphyrinogen IX biosynthetic process (GO:0006782)4.46237308
5telomere maintenance via semi-conservative replication (GO:0032201)4.09146494
6DNA strand elongation involved in DNA replication (GO:0006271)4.08503369
7chaperone-mediated protein transport (GO:0072321)3.92341017
8viral transcription (GO:0019083)3.88459540
9DNA strand elongation (GO:0022616)3.85790119
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.82466241
11translational termination (GO:0006415)3.78846953
12formation of translation preinitiation complex (GO:0001731)3.78436184
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.77934305
14DNA replication initiation (GO:0006270)3.66359457
15telomere maintenance via recombination (GO:0000722)3.56854585
16translational elongation (GO:0006414)3.54929911
17folic acid-containing compound biosynthetic process (GO:0009396)3.53425155
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.51246297
19protein targeting to membrane (GO:0006612)3.47725817
20maturation of SSU-rRNA (GO:0030490)3.44683346
21negative regulation of erythrocyte differentiation (GO:0045647)3.39171138
22protein maturation by protein folding (GO:0022417)3.39043532
23protein localization to kinetochore (GO:0034501)3.36439271
24pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.34114163
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32974863
26modulation by virus of host process (GO:0019054)3.30978087
27GDP-mannose metabolic process (GO:0019673)3.30937788
28translational initiation (GO:0006413)3.29499163
29heme biosynthetic process (GO:0006783)3.25135447
30cellular component biogenesis (GO:0044085)3.24782567
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22209344
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22209344
33protein targeting to ER (GO:0045047)3.20848367
34DNA unwinding involved in DNA replication (GO:0006268)3.20648214
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19724918
36cotranslational protein targeting to membrane (GO:0006613)3.19706972
37IMP biosynthetic process (GO:0006188)3.16700448
38protein targeting to mitochondrion (GO:0006626)3.14186554
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14079758
40regulation of protein heterodimerization activity (GO:0043497)3.14023508
41antigen processing and presentation of endogenous antigen (GO:0019883)3.13674727
42UV protection (GO:0009650)3.11978139
43mitotic recombination (GO:0006312)3.10815017
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09685858
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07896801
46pyrimidine nucleotide catabolic process (GO:0006244)3.07170490
47proline biosynthetic process (GO:0006561)3.06942995
48ATP synthesis coupled proton transport (GO:0015986)3.05983763
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05983763
50nucleobase biosynthetic process (GO:0046112)3.05581466
51NIK/NF-kappaB signaling (GO:0038061)3.05120886
52deoxyribose phosphate biosynthetic process (GO:0046385)3.03645316
532-deoxyribonucleotide biosynthetic process (GO:0009265)3.03645316
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03595902
55mitotic nuclear envelope disassembly (GO:0007077)3.02823863
56DNA replication checkpoint (GO:0000076)3.01502891
57protein localization to endoplasmic reticulum (GO:0070972)3.00616163
58ribosomal small subunit biogenesis (GO:0042274)3.00055223
59T cell apoptotic process (GO:0070231)2.99709503
60rRNA modification (GO:0000154)2.98913759
61protein localization to chromosome, centromeric region (GO:0071459)2.96199716
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94810699
63negative regulation of DNA-templated transcription, elongation (GO:0032785)2.92276105
64telomere maintenance via telomere lengthening (GO:0010833)2.92229487
65viral life cycle (GO:0019058)2.90977496
66modulation by symbiont of host cellular process (GO:0044068)2.89384818
67establishment of protein localization to mitochondrion (GO:0072655)2.89350878
68negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88630621
69cellular protein complex disassembly (GO:0043624)2.88543800
70positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.87162899
71ribosomal large subunit biogenesis (GO:0042273)2.86244807
72nucleotide-excision repair, DNA gap filling (GO:0006297)2.85918095
73IMP metabolic process (GO:0046040)2.84884470
74pseudouridine synthesis (GO:0001522)2.84239772
75ribosome assembly (GO:0042255)2.83335694
76activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.83029360
77proteasome assembly (GO:0043248)2.82998822
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81578291
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79769331
80protein localization to mitochondrion (GO:0070585)2.79703966
81folic acid metabolic process (GO:0046655)2.79515263
82transcription-coupled nucleotide-excision repair (GO:0006283)2.78665973
83tetrapyrrole biosynthetic process (GO:0033014)2.78362231
84peptidyl-arginine omega-N-methylation (GO:0035247)2.77825709
85mitotic chromosome condensation (GO:0007076)2.76632361
86pentose-phosphate shunt (GO:0006098)2.75146021
87membrane disassembly (GO:0030397)2.74932956
88nuclear envelope disassembly (GO:0051081)2.74932956
89base-excision repair, AP site formation (GO:0006285)2.74594916
90cellular response to zinc ion (GO:0071294)2.73938592
91mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.72634307
92viral protein processing (GO:0019082)2.72340170
93ribonucleoprotein complex biogenesis (GO:0022613)2.72149826
94mitochondrial fusion (GO:0008053)2.71305490
95porphyrin-containing compound metabolic process (GO:0006778)2.70170864
96regulation of mitochondrial translation (GO:0070129)2.69085258
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68427355
98immunoglobulin mediated immune response (GO:0016064)2.67720061
99neutrophil activation involved in immune response (GO:0002283)2.67386533
100purine-containing compound salvage (GO:0043101)2.65511089
101B cell mediated immunity (GO:0019724)2.65327230
102ribosome biogenesis (GO:0042254)2.65118713
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65037633
104positive regulation of protein homooligomerization (GO:0032464)2.65026918
105purine nucleobase biosynthetic process (GO:0009113)2.63865619
106translation (GO:0006412)2.62621156
107guanosine-containing compound biosynthetic process (GO:1901070)2.62511210
108positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.62279719
109tRNA methylation (GO:0030488)2.61129335
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.60721512
111termination of RNA polymerase III transcription (GO:0006386)2.60721512
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60498517
113mitotic G1 DNA damage checkpoint (GO:0031571)2.60375984
114pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.59889059
115ncRNA 3-end processing (GO:0043628)2.59211901
116negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59183802
117regulation of release of cytochrome c from mitochondria (GO:0090199)2.57403776
118nucleobase-containing small molecule interconversion (GO:0015949)2.56683792
119heme metabolic process (GO:0042168)2.56081278
120establishment of protein localization to membrane (GO:0090150)2.55638705
121oxygen transport (GO:0015671)2.55117163
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54990115
123protein complex disassembly (GO:0043241)2.54554834
124porphyrin-containing compound biosynthetic process (GO:0006779)2.54034346
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53885658
126pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.53809699
127rRNA transcription (GO:0009303)2.53403750
128negative regulation of RNA splicing (GO:0033119)2.53103157
129rRNA processing (GO:0006364)2.52396859
130deoxyribonucleotide catabolic process (GO:0009264)2.51466357
131pentose metabolic process (GO:0019321)2.49881962
132natural killer cell mediated cytotoxicity (GO:0042267)2.49823714
133natural killer cell mediated immunity (GO:0002228)2.49823714
134positive regulation of natural killer cell differentiation (GO:0032825)2.49781202
135rRNA methylation (GO:0031167)2.49489201
136nuclear-transcribed mRNA catabolic process (GO:0000956)2.48833424
137positive regulation of B cell differentiation (GO:0045579)2.48102522
138cellular response to virus (GO:0098586)2.47835378
139G1/S transition of mitotic cell cycle (GO:0000082)2.47311270
140cell cycle G1/S phase transition (GO:0044843)2.47311270
141pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.46277508
142lymphocyte apoptotic process (GO:0070227)2.45309974
143DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43972420
144rRNA metabolic process (GO:0016072)2.43019428
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.42783994
146negative regulation of ligase activity (GO:0051352)2.42783994
147antigen processing and presentation via MHC class Ib (GO:0002475)2.41457486
148intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40318708
149signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40318708
150RNA catabolic process (GO:0006401)2.40292900
151CENP-A containing nucleosome assembly (GO:0034080)2.38833177
152mRNA catabolic process (GO:0006402)2.38594201
153macromolecular complex disassembly (GO:0032984)2.37382447
154signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.36149074
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.36149074
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.36149074
157regulation of translational termination (GO:0006449)2.36043990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.04942604
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.22760891
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.45759374
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76395412
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.64730470
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50441567
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45711029
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.40419364
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35995072
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.33445865
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31769072
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.29422085
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.28308932
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24648188
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.23998439
16VDR_21846776_ChIP-Seq_THP-1_Human2.23122235
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19750446
18MYC_22102868_ChIP-Seq_BL_Human2.19420939
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14233505
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10590515
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.06845793
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00625297
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98126974
24* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97891023
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97725809
26XRN2_22483619_ChIP-Seq_HELA_Human1.95011881
27VDR_23849224_ChIP-Seq_CD4+_Human1.89449121
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89300734
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86911680
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84215415
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83538551
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83445740
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79509790
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76815635
35DCP1A_22483619_ChIP-Seq_HELA_Human1.75458250
36LXR_22292898_ChIP-Seq_THP-1_Human1.74566535
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71557641
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68963729
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66737655
40* GABP_19822575_ChIP-Seq_HepG2_Human1.66217084
41SPI1_23547873_ChIP-Seq_NB4_Human1.63084548
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.60705006
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59746197
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59190099
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59121344
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.58059391
47FOXP3_21729870_ChIP-Seq_TREG_Human1.56695898
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51334543
49P68_20966046_ChIP-Seq_HELA_Human1.46838807
50* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46785415
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45483044
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.45349419
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44739125
54CIITA_25753668_ChIP-Seq_RAJI_Human1.43351432
55TFEB_21752829_ChIP-Seq_HELA_Human1.43333473
56* SRF_21415370_ChIP-Seq_HL-1_Mouse1.43036945
57AR_21909140_ChIP-Seq_LNCAP_Human1.42670308
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41865886
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41498617
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39312551
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38534442
62* TTF2_22483619_ChIP-Seq_HELA_Human1.37843469
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37731568
64* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36430334
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35657666
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32965983
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32909691
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32268660
69MAF_26560356_Chip-Seq_TH1_Human1.32015408
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30929642
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30871813
72VDR_24763502_ChIP-Seq_THP-1_Human1.30545194
73SCL_19346495_ChIP-Seq_HPC-7_Human1.29970374
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28386188
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27717988
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27626650
77BCL6_27268052_Chip-Seq_Bcells_Human1.27425007
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27302809
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.25580428
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24319651
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24319330
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23891446
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.21232163
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20924155
85KDM5A_27292631_Chip-Seq_BREAST_Human1.20812402
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.20749009
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20087565
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20038868
89BCOR_27268052_Chip-Seq_Bcells_Human1.19572209
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19188879
91* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18935133
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17752973
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.17620829
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17389200
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17218070
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17060003
97* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16028644
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15431469
99NCOR1_26117541_ChIP-Seq_K562_Human1.14715963
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14187965
101ELK1_19687146_ChIP-ChIP_HELA_Human1.13903484
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13888116
103RACK7_27058665_Chip-Seq_MCF-7_Human1.13207555
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12312652
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12058619
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11408620
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11344070
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.11040614
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10706720
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10493823
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.10053935
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.09720175
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08629567
114MYB_26560356_Chip-Seq_TH2_Human1.08553959
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07881529
116KDM2B_26808549_Chip-Seq_DND41_Human1.07672733
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07424735
118* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06825246
119MYB_26560356_Chip-Seq_TH1_Human1.06577263
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06350782
121CTCF_21964334_Chip-Seq_Bcells_Human1.06251648
122UTX_26944678_Chip-Seq_JUKART_Human1.06135645
123MAF_26560356_Chip-Seq_TH2_Human1.04924691
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02537401
125* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02279234
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94620073
127TCF7_22412390_ChIP-Seq_EML_Mouse0.94145219
128ZNF263_19887448_ChIP-Seq_K562_Human0.94024600
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93398530
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91708843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.79410079
2MP0003693_abnormal_embryo_hatching3.30360097
3MP0001835_abnormal_antigen_presentation3.17729876
4MP0002396_abnormal_hematopoietic_system3.09357308
5MP0003111_abnormal_nucleus_morphology2.76334210
6MP0005451_abnormal_body_composition2.73274920
7MP0010094_abnormal_chromosome_stability2.70249024
8MP0003656_abnormal_erythrocyte_physiolo2.62686190
9* MP0000685_abnormal_immune_system2.55049174
10MP0005397_hematopoietic_system_phenotyp2.51076570
11MP0001545_abnormal_hematopoietic_system2.51076570
12MP0003077_abnormal_cell_cycle2.49672219
13MP0004957_abnormal_blastocyst_morpholog2.48376079
14MP0003436_decreased_susceptibility_to2.28158347
15MP0008057_abnormal_DNA_replication2.25562103
16MP0010307_abnormal_tumor_latency2.17248789
17MP0009333_abnormal_splenocyte_physiolog2.08205925
18MP0000490_abnormal_crypts_of2.06589897
19MP0008260_abnormal_autophagy2.03199412
20MP0004808_abnormal_hematopoietic_stem2.02468113
21MP0004233_abnormal_muscle_weight1.99764279
22* MP0002398_abnormal_bone_marrow1.96747171
23MP0005671_abnormal_response_to1.96515315
24MP0001800_abnormal_humoral_immune1.94370658
25MP0009785_altered_susceptibility_to1.93753688
26MP0006054_spinal_hemorrhage1.92899931
27MP0008007_abnormal_cellular_replicative1.92182088
28MP0002148_abnormal_hypersensitivity_rea1.92121576
29MP0002163_abnormal_gland_morphology1.91499950
30MP0002452_abnormal_antigen_presenting1.90845504
31MP0001853_heart_inflammation1.90597360
32MP0008058_abnormal_DNA_repair1.88900316
33MP0005000_abnormal_immune_tolerance1.87404259
34MP0010352_gastrointestinal_tract_polyps1.83463336
35MP0005025_abnormal_response_to1.82771313
36MP0002419_abnormal_innate_immunity1.76247222
37MP0001819_abnormal_immune_cell1.74007476
38* MP0000689_abnormal_spleen_morphology1.73759219
39MP0002420_abnormal_adaptive_immunity1.73044676
40* MP0002723_abnormal_immune_serum1.71357426
41MP0001790_abnormal_immune_system1.71192155
42MP0005387_immune_system_phenotype1.71192155
43MP0005058_abnormal_lysosome_morphology1.71078320
44* MP0002722_abnormal_immune_system1.67847535
45MP0002166_altered_tumor_susceptibility1.63467094
46MP0005464_abnormal_platelet_physiology1.62710916
47MP0001348_abnormal_lacrimal_gland1.62435409
48* MP0002429_abnormal_blood_cell1.61428765
49* MP0000716_abnormal_immune_system1.61084562
50MP0000858_altered_metastatic_potential1.56367669
51MP0003303_peritoneal_inflammation1.49720548
52MP0002405_respiratory_system_inflammati1.45975181
53MP0004147_increased_porphyrin_level1.45718130
54MP0003763_abnormal_thymus_physiology1.45336247
55MP0002132_abnormal_respiratory_system1.43204717
56MP0002019_abnormal_tumor_incidence1.42935453
57MP0003172_abnormal_lysosome_physiology1.42768930
58MP0009278_abnormal_bone_marrow1.40154977
59MP0000350_abnormal_cell_proliferation1.36042479
60MP0003186_abnormal_redox_activity1.30420463
61* MP0000313_abnormal_cell_death1.28389832
62MP0005076_abnormal_cell_differentiation1.27107329
63MP0004510_myositis1.27105848
64MP0002006_tumorigenesis1.25206513
65* MP0000703_abnormal_thymus_morphology1.24672053
66MP0000678_abnormal_parathyroid_gland1.22853312
67MP0008932_abnormal_embryonic_tissue1.22613316
68MP0003866_abnormal_defecation1.20894203
69MP0001845_abnormal_inflammatory_respons1.20303015
70MP0006082_CNS_inflammation1.19452731
71MP0005501_abnormal_skin_physiology1.18605582
72MP0009840_abnormal_foam_cell1.18368470
73MP0004185_abnormal_adipocyte_glucose1.17987113
74MP0005174_abnormal_tail_pigmentation1.14287116
75MP0003959_abnormal_lean_body1.13468398
76MP0001730_embryonic_growth_arrest1.13125099
77MP0003448_altered_tumor_morphology1.12701181
78MP0001873_stomach_inflammation1.11788718
79MP0010155_abnormal_intestine_physiology1.08666229
80* MP0008469_abnormal_protein_level1.07076157
81MP0001533_abnormal_skeleton_physiology1.06651283
82MP0001661_extended_life_span1.03705961
83MP0003724_increased_susceptibility_to1.03662111
84MP0009765_abnormal_xenobiotic_induced1.03613039
85MP0001905_abnormal_dopamine_level1.03196572
86* MP0006035_abnormal_mitochondrial_morpho1.00670038
87MP0003183_abnormal_peptide_metabolism1.00097104
88MP0000343_altered_response_to0.99996339
89MP0004947_skin_inflammation0.99218207
90MP0010030_abnormal_orbit_morphology0.98613232
91MP0003566_abnormal_cell_adhesion0.98336282
92MP0003786_premature_aging0.97661108
93MP0002877_abnormal_melanocyte_morpholog0.96410651
94MP0009764_decreased_sensitivity_to0.95827842
95MP0003705_abnormal_hypodermis_morpholog0.95314093
96MP0002080_prenatal_lethality0.94285829
97MP0008438_abnormal_cutaneous_collagen0.94264408
98MP0005023_abnormal_wound_healing0.92820640
99* MP0000358_abnormal_cell_content/0.88218726
100MP0003806_abnormal_nucleotide_metabolis0.87594701
101MP0001915_intracranial_hemorrhage0.84145125
102MP0000750_abnormal_muscle_regeneration0.84131894
103MP0000371_diluted_coat_color0.84032622
104MP0001697_abnormal_embryo_size0.83600194
105MP0002210_abnormal_sex_determination0.83370435
106MP0005621_abnormal_cell_physiology0.81701641
107MP0005310_abnormal_salivary_gland0.80700439
108MP0009931_abnormal_skin_appearance0.79759861
109MP0000015_abnormal_ear_pigmentation0.78565255
110MP0001727_abnormal_embryo_implantation0.78401120
111MP0000465_gastrointestinal_hemorrhage0.77902992
112MP0005075_abnormal_melanosome_morpholog0.75632200
113MP0005319_abnormal_enzyme/_coenzyme0.75465942
114MP0008995_early_reproductive_senescence0.75428485
115MP0006292_abnormal_olfactory_placode0.75368091
116MP0005666_abnormal_adipose_tissue0.74574021
117MP0003123_paternal_imprinting0.74398115
118MP0009763_increased_sensitivity_to0.74109180
119MP0000598_abnormal_liver_morphology0.73811759
120MP0002138_abnormal_hepatobiliary_system0.73448174
121MP0005584_abnormal_enzyme/coenzyme_acti0.73384007
122MP0000681_abnormal_thyroid_gland0.72365324
123MP0003984_embryonic_growth_retardation0.72290504
124MP0005083_abnormal_biliary_tract0.71285033
125* MP0005384_cellular_phenotype0.71025565
126MP0000609_abnormal_liver_physiology0.70522981
127MP0002086_abnormal_extraembryonic_tissu0.70359108
128MP0002088_abnormal_embryonic_growth/wei0.69590771
129MP0003191_abnormal_cellular_cholesterol0.69280415
130MP0006036_abnormal_mitochondrial_physio0.69124117
131MP0001672_abnormal_embryogenesis/_devel0.66869205

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.96369415
2Abnormality of cells of the erythroid lineage (HP:0012130)4.91441224
3Thrombocytosis (HP:0001894)4.22381951
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.05075319
5Reticulocytopenia (HP:0001896)3.56089624
6Recurrent abscess formation (HP:0002722)3.55790765
7Petechiae (HP:0000967)3.37301318
8Aplastic anemia (HP:0001915)3.32016580
9Agammaglobulinemia (HP:0004432)3.24970285
10Birth length less than 3rd percentile (HP:0003561)3.14004121
11Elevated erythrocyte sedimentation rate (HP:0003565)3.12813785
12Recurrent bacterial skin infections (HP:0005406)3.11465622
13Abnormal hemoglobin (HP:0011902)3.07648598
14Pallor (HP:0000980)3.05789053
15Autoimmune thrombocytopenia (HP:0001973)2.90810588
16Hypertensive crisis (HP:0100735)2.85871771
17Eczematoid dermatitis (HP:0000976)2.80377248
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78711490
19Myositis (HP:0100614)2.75259295
20Chronic otitis media (HP:0000389)2.70802456
21Vertebral compression fractures (HP:0002953)2.70451254
22Increased muscle lipid content (HP:0009058)2.69081621
23Abnormal mitochondria in muscle tissue (HP:0008316)2.68462755
24Esophageal neoplasm (HP:0100751)2.65155708
25Neoplasm of head and neck (HP:0012288)2.65155708
26Abnormality of reticulocytes (HP:0004312)2.62001144
27Poor head control (HP:0002421)2.61127873
28Increased intramyocellular lipid droplets (HP:0012240)2.60902043
29Gastrointestinal stroma tumor (HP:0100723)2.59138974
30Progressive muscle weakness (HP:0003323)2.58961960
31Increased serum ferritin (HP:0003281)2.58859708
32Abnormality of T cell physiology (HP:0011840)2.56473779
33Cholelithiasis (HP:0001081)2.56234961
34IgM deficiency (HP:0002850)2.54791426
35Recurrent viral infections (HP:0004429)2.50963218
36Cholecystitis (HP:0001082)2.50195512
37Abnormal gallbladder physiology (HP:0012438)2.50195512
38Selective tooth agenesis (HP:0001592)2.49048613
39Mediastinal lymphadenopathy (HP:0100721)2.48177748
40Abnormality of macrophages (HP:0004311)2.45718661
41Panhypogammaglobulinemia (HP:0003139)2.45134981
42Purpura (HP:0000979)2.39309349
43Recurrent fungal infections (HP:0002841)2.36926980
44Oral leukoplakia (HP:0002745)2.35672536
45Entropion (HP:0000621)2.35301857
46Truncus arteriosus (HP:0001660)2.34743109
47Hyperthyroidism (HP:0000836)2.33302378
48Microretrognathia (HP:0000308)2.33078777
49Paralysis (HP:0003470)2.31538810
50Macrocytic anemia (HP:0001972)2.30880093
51Mitochondrial inheritance (HP:0001427)2.30170123
52Cellulitis (HP:0100658)2.29626186
53Acute necrotizing encephalopathy (HP:0006965)2.29565122
54Poikiloderma (HP:0001029)2.28533590
55Broad distal phalanx of finger (HP:0009836)2.26176792
56Chronic mucocutaneous candidiasis (HP:0002728)2.25881944
57Recurrent cutaneous fungal infections (HP:0011370)2.25881944
58Myelodysplasia (HP:0002863)2.23752719
59Acute encephalopathy (HP:0006846)2.22958176
60Agnosia (HP:0010524)2.22255270
61Microvesicular hepatic steatosis (HP:0001414)2.22075247
62Polycythemia (HP:0001901)2.21346306
63Amaurosis fugax (HP:0100576)2.18721877
64Hepatocellular necrosis (HP:0001404)2.18422978
65Pustule (HP:0200039)2.17584534
66Seborrheic dermatitis (HP:0001051)2.16922240
67Increased IgM level (HP:0003496)2.16628886
68Ragged-red muscle fibers (HP:0003200)2.16297465
69Exertional dyspnea (HP:0002875)2.15144155
70Hepatosplenomegaly (HP:0001433)2.14856823
71Granulocytopenia (HP:0001913)2.12194395
72Microcytic anemia (HP:0001935)2.11278068
73Fatigue (HP:0012378)2.10435144
74Nausea (HP:0002018)2.09597596
75Reticulocytosis (HP:0001923)2.09076374
76Exercise intolerance (HP:0003546)2.08621692
77Prolonged bleeding time (HP:0003010)2.08519818
78Slender long bone (HP:0003100)2.08194286
79Hypokinesia (HP:0002375)2.08037750
80Epistaxis (HP:0000421)2.07891237
81Impaired platelet aggregation (HP:0003540)2.07745803
82Abnormal platelet function (HP:0011869)2.07745803
83Abnormality of the thoracic spine (HP:0100711)2.06886572
84Albinism (HP:0001022)2.06041396
85Abnormality of iron homeostasis (HP:0011031)2.05488033
86Type I transferrin isoform profile (HP:0003642)2.03896824
87Prolonged neonatal jaundice (HP:0006579)2.01619429
88Rough bone trabeculation (HP:0100670)2.01448604
89Squamous cell carcinoma (HP:0002860)2.00972093
90Increased IgE level (HP:0003212)2.00624332
91Respiratory difficulties (HP:0002880)2.00612180
92Opisthotonus (HP:0002179)1.99642081
93Hepatic necrosis (HP:0002605)1.99086142
94Abnormal gallbladder morphology (HP:0012437)1.98899214
95Increased CSF lactate (HP:0002490)1.98802076
96Hypoparathyroidism (HP:0000829)1.98786658
97Multiple enchondromatosis (HP:0005701)1.97251094
98Pulmonary fibrosis (HP:0002206)1.97126209
99Increased serum lactate (HP:0002151)1.95693455
100Basal ganglia calcification (HP:0002135)1.93711381
101Hypochromic anemia (HP:0001931)1.93643234
102Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93046262
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93046262
104Abnormality of DNA repair (HP:0003254)1.92808861
105Lymphoma (HP:0002665)1.92719013
106Nonimmune hydrops fetalis (HP:0001790)1.91719850
107Orchitis (HP:0100796)1.91582777
108Recurrent skin infections (HP:0001581)1.91248949
109Recurrent bronchitis (HP:0002837)1.91105569
110Abnormality of the anterior horn cell (HP:0006802)1.91064197
111Degeneration of anterior horn cells (HP:0002398)1.91064197
112Aplasia/Hypoplasia of the thymus (HP:0010515)1.90517856
113Vasculitis (HP:0002633)1.90194689
114Vacuolated lymphocytes (HP:0001922)1.89693715
115Pancytopenia (HP:0001876)1.89533939
116Interstitial pulmonary disease (HP:0006530)1.88773739
117Neutropenia (HP:0001875)1.88573010
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88447139
119Renal Fanconi syndrome (HP:0001994)1.88427930
120Hypertriglyceridemia (HP:0002155)1.87974145
121Abnormality of T cells (HP:0002843)1.87747507
122Gastrointestinal infarctions (HP:0005244)1.87650121
123Abnormality of the nasal mucosa (HP:0000433)1.86419702
124Abnormality of lateral ventricle (HP:0030047)1.86289190
125Ileus (HP:0002595)1.86046472
126Abnormality of the gallbladder (HP:0005264)1.85116418
127Abnormality of transition element cation homeostasis (HP:0011030)1.85033246
128Peritonitis (HP:0002586)1.84413892
129Colitis (HP:0002583)1.84203417
130Cervical subluxation (HP:0003308)1.83613995
131Achilles tendon contracture (HP:0001771)1.83474992
132Cutaneous photosensitivity (HP:0000992)1.83344783
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.82880706
134Joint stiffness (HP:0001387)1.82828267
135Nasal polyposis (HP:0100582)1.82426478
136Osteolytic defects of the hand bones (HP:0009699)1.82133085
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.82133085
138Increased serum pyruvate (HP:0003542)1.81390975
139Biconcave vertebral bodies (HP:0004586)1.81199105
140Lactic acidosis (HP:0003128)1.80786300
141Poikilocytosis (HP:0004447)1.80727335
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.80169983
143Chest pain (HP:0100749)1.79142554
144Premature graying of hair (HP:0002216)1.78392445
145Obstructive lung disease (HP:0006536)1.77735767
146Chronic obstructive pulmonary disease (HP:0006510)1.77735767
147Encephalitis (HP:0002383)1.77493486
148Meningitis (HP:0001287)1.77377123
149Recurrent gram-negative bacterial infections (HP:0005420)1.77345513
150Muscle fiber atrophy (HP:0100295)1.77228923
151Urticaria (HP:0001025)1.77108702
152Arterial thrombosis (HP:0004420)1.76181759
153Breast hypoplasia (HP:0003187)1.75624969
154Reduced antithrombin III activity (HP:0001976)1.74848864
155Hypoplasia of the pons (HP:0012110)1.74483649
156Gastrointestinal inflammation (HP:0004386)1.71761840
157Protrusio acetabuli (HP:0003179)1.71276124
158Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71096562
159Increased cerebral lipofuscin (HP:0011813)1.71013537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.25826982
2PIM23.03331011
3BUB12.86987252
4WEE12.77811810
5TRIB32.47626079
6EIF2AK12.44149462
7PRPF4B2.43405217
8SMG12.39386674
9MAP4K12.06730698
10VRK21.98672428
11PKN21.98240919
12ERN11.98233533
13CDC71.93721390
14EEF2K1.92841736
15NEK21.92721236
16ACVR1B1.91326520
17SCYL21.90109153
18BRSK21.89734341
19RPS6KA41.89412765
20TYK21.87050161
21TBK11.83436231
22MAPKAPK31.74422073
23JAK31.70453818
24KIT1.64248968
25FLT31.61769983
26MAP3K101.60703395
27TAF11.58365105
28BLK1.55464904
29STK161.48572658
30MAP3K111.43654191
31IKBKB1.43319228
32ZAP701.39036649
33EIF2AK31.38915006
34PIM11.38490342
35MAP3K141.38096096
36LRRK21.37938726
37PAK41.30948658
38TESK21.30241804
39NEK11.28117127
40TGFBR11.27740441
41MAP3K11.26722969
42KDR1.24886049
43VRK11.20786766
44MAP3K81.20151922
45MAP2K31.18481399
46DYRK31.18385196
47RPS6KB21.16952659
48BTK1.15757030
49STK101.14049689
50ZAK1.13900925
51BRSK11.12847748
52CDK81.12803007
53CSF1R1.10636040
54RPS6KA51.08383743
55IRAK41.06702035
56ATR1.06670571
57CDK41.04084926
58STK41.01481034
59PLK11.00427524
60SYK1.00179695
61CDK70.99461788
62SIK10.98962712
63TTN0.98930507
64MAP3K130.98847804
65TSSK60.95607521
66AURKB0.94533829
67FGFR40.92219796
68KSR20.92013294
69ICK0.91359534
70TAOK10.88630982
71MAP3K30.88392102
72NEK90.87692545
73FES0.87590257
74DAPK10.85549649
75EPHB10.81751953
76DAPK30.79287309
77TESK10.78740741
78ARAF0.78474890
79MATK0.78088450
80PLK40.77206329
81TGFBR20.76945631
82DYRK20.76064522
83PDK20.75308104
84CDK190.75117314
85IKBKE0.73824723
86BMX0.73797527
87ILK0.72891484
88RIPK40.72616568
89CHUK0.70600689
90SRPK10.69973627
91IRAK30.69729744
92RAF10.69537322
93NME10.69435568
94MAPK110.69267874
95ABL20.69155580
96MAPKAPK20.68045360
97GRK60.67521528
98LYN0.66851576
99MOS0.66234034
100BCKDK0.65511188
101MAP2K20.65367614
102TEC0.64442543
103PAK10.63889494
104AURKA0.60543622
105SIK20.58671319
106TLK10.57897519
107TAOK30.56142426
108IRAK20.56000628
109EIF2AK20.55912678
110RPS6KA60.54547020
111NTRK10.53360013
112PRKD20.53068471
113MARK30.52537783
114DYRK1B0.51162753
115BRAF0.49644980
116CHEK10.49244435
117TRPM70.48830117
118CCNB10.48033780
119CHEK20.47160320
120JAK10.46659534
121RPS6KL10.46109460
122RPS6KC10.46109460
123JAK20.45599262
124PRKCI0.45572822
125CDK60.45154956
126MAP3K60.44373907
127TAOK20.43978120
128LCK0.43755408
129TTK0.43206454
130MAP3K50.43084988
131MARK20.40814578
132HIPK20.39731010
133PDPK10.39493823
134RPS6KA20.37861695
135PKN10.35085405
136CSNK2A20.34092372
137RPS6KA10.32279713
138EPHA30.32257604

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58612817
2Ribosome_Homo sapiens_hsa030103.40350189
3Proteasome_Homo sapiens_hsa030503.06634330
4Mismatch repair_Homo sapiens_hsa034303.03284159
5Base excision repair_Homo sapiens_hsa034102.96665524
6Oxidative phosphorylation_Homo sapiens_hsa001902.35874131
7Parkinsons disease_Homo sapiens_hsa050122.35360052
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28876597
9One carbon pool by folate_Homo sapiens_hsa006702.17317239
10Spliceosome_Homo sapiens_hsa030402.11627199
11Homologous recombination_Homo sapiens_hsa034402.08118771
12Pyrimidine metabolism_Homo sapiens_hsa002402.02936256
13Nucleotide excision repair_Homo sapiens_hsa034202.01820061
14RNA transport_Homo sapiens_hsa030131.94750813
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90391472
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88700085
17RNA polymerase_Homo sapiens_hsa030201.87999876
18Cell cycle_Homo sapiens_hsa041101.83268020
19Huntingtons disease_Homo sapiens_hsa050161.80600845
20p53 signaling pathway_Homo sapiens_hsa041151.66662606
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62439125
22Leishmaniasis_Homo sapiens_hsa051401.55803779
23Legionellosis_Homo sapiens_hsa051341.51989321
24Herpes simplex infection_Homo sapiens_hsa051681.46706695
25Antigen processing and presentation_Homo sapiens_hsa046121.44598104
26Alzheimers disease_Homo sapiens_hsa050101.35053404
27Sulfur relay system_Homo sapiens_hsa041221.30959046
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.29671137
29Epstein-Barr virus infection_Homo sapiens_hsa051691.28187527
30Pentose phosphate pathway_Homo sapiens_hsa000301.27687492
31Alcoholism_Homo sapiens_hsa050341.27135730
32* Apoptosis_Homo sapiens_hsa042101.26779610
33Measles_Homo sapiens_hsa051621.26684312
34Allograft rejection_Homo sapiens_hsa053301.26663179
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25575647
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24760509
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.22413553
38RNA degradation_Homo sapiens_hsa030181.19664270
39Non-homologous end-joining_Homo sapiens_hsa034501.13607198
40Fanconi anemia pathway_Homo sapiens_hsa034601.13387809
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11416130
42Shigellosis_Homo sapiens_hsa051311.10197203
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06292791
44Primary immunodeficiency_Homo sapiens_hsa053401.05588184
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04402373
46Non-small cell lung cancer_Homo sapiens_hsa052230.99221080
47Influenza A_Homo sapiens_hsa051640.98872638
48Viral carcinogenesis_Homo sapiens_hsa052030.98338411
49B cell receptor signaling pathway_Homo sapiens_hsa046620.96037115
50Viral myocarditis_Homo sapiens_hsa054160.94397304
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91685508
52Osteoclast differentiation_Homo sapiens_hsa043800.91439441
53Systemic lupus erythematosus_Homo sapiens_hsa053220.91106299
54Small cell lung cancer_Homo sapiens_hsa052220.90677147
55Other glycan degradation_Homo sapiens_hsa005110.88401147
56Bladder cancer_Homo sapiens_hsa052190.88275095
57Hepatitis B_Homo sapiens_hsa051610.88108699
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.86776654
59Folate biosynthesis_Homo sapiens_hsa007900.86697079
60Purine metabolism_Homo sapiens_hsa002300.85963602
61Acute myeloid leukemia_Homo sapiens_hsa052210.85732552
62Toxoplasmosis_Homo sapiens_hsa051450.83508973
63N-Glycan biosynthesis_Homo sapiens_hsa005100.83125295
64Biosynthesis of amino acids_Homo sapiens_hsa012300.82726623
65Pancreatic cancer_Homo sapiens_hsa052120.79921574
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79798213
67HTLV-I infection_Homo sapiens_hsa051660.78729380
68Tuberculosis_Homo sapiens_hsa051520.78672258
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77395052
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.77162012
71Chronic myeloid leukemia_Homo sapiens_hsa052200.77146037
72Pertussis_Homo sapiens_hsa051330.75451348
73Hematopoietic cell lineage_Homo sapiens_hsa046400.73250951
74Galactose metabolism_Homo sapiens_hsa000520.72965413
75Malaria_Homo sapiens_hsa051440.72170306
76TNF signaling pathway_Homo sapiens_hsa046680.72085611
77VEGF signaling pathway_Homo sapiens_hsa043700.71906410
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70860041
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68814233
80Fructose and mannose metabolism_Homo sapiens_hsa000510.68008487
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66907812
82Cardiac muscle contraction_Homo sapiens_hsa042600.65410256
83Lysosome_Homo sapiens_hsa041420.65116411
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64547204
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.63665474
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61893947
87Prion diseases_Homo sapiens_hsa050200.61094792
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59968382
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59622942
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59127952
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57386078
92Asthma_Homo sapiens_hsa053100.56824282
93Fatty acid elongation_Homo sapiens_hsa000620.56280080
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56221605
95HIF-1 signaling pathway_Homo sapiens_hsa040660.55683309
96Graft-versus-host disease_Homo sapiens_hsa053320.54680335
97Selenocompound metabolism_Homo sapiens_hsa004500.53500860
98Notch signaling pathway_Homo sapiens_hsa043300.52913914
99Carbon metabolism_Homo sapiens_hsa012000.52804850
100Glutathione metabolism_Homo sapiens_hsa004800.50747875
101mRNA surveillance pathway_Homo sapiens_hsa030150.49096875
102Salmonella infection_Homo sapiens_hsa051320.46880593
103Vibrio cholerae infection_Homo sapiens_hsa051100.46522549
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46122010
105Basal transcription factors_Homo sapiens_hsa030220.44994507
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44864306
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43404955
108Autoimmune thyroid disease_Homo sapiens_hsa053200.43119222
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42891181
110Pyruvate metabolism_Homo sapiens_hsa006200.42023529
111Renin-angiotensin system_Homo sapiens_hsa046140.41648115
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41373873
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.40562466
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40542621
115Hepatitis C_Homo sapiens_hsa051600.40539178
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.40521234
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39654537
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39507148
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38865499
120Metabolic pathways_Homo sapiens_hsa011000.38725182
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38525308
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38179265
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37582703
124Protein export_Homo sapiens_hsa030600.37248590
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.36911499
126T cell receptor signaling pathway_Homo sapiens_hsa046600.36443965
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35068318
128Collecting duct acid secretion_Homo sapiens_hsa049660.33322303
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.30000366

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