HTR5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)5.89211771
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83315208
3cerebellar granule cell differentiation (GO:0021707)5.72965092
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.70672267
5synaptic vesicle exocytosis (GO:0016079)5.69204846
6glutamate secretion (GO:0014047)5.55522631
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42303699
8vocalization behavior (GO:0071625)5.32327120
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30982094
10synaptic vesicle maturation (GO:0016188)5.14892340
11locomotory exploration behavior (GO:0035641)5.06279945
12neuron cell-cell adhesion (GO:0007158)4.99443327
13protein localization to synapse (GO:0035418)4.91945970
14regulation of glutamate receptor signaling pathway (GO:1900449)4.86852525
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.85805929
16regulation of synaptic vesicle exocytosis (GO:2000300)4.75164072
17retinal cone cell development (GO:0046549)4.74106473
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.57317182
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.51545317
20L-amino acid import (GO:0043092)4.50768737
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.45015599
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43875788
23regulation of synaptic vesicle transport (GO:1902803)4.41778418
24neuronal action potential propagation (GO:0019227)4.39041075
25glutamate receptor signaling pathway (GO:0007215)4.31402386
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.28987942
27synaptic transmission, glutamatergic (GO:0035249)4.27287141
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21555864
29neuron-neuron synaptic transmission (GO:0007270)4.21485406
30neurotransmitter secretion (GO:0007269)4.18118411
31cellular sodium ion homeostasis (GO:0006883)4.18039912
32exploration behavior (GO:0035640)4.12427218
33response to histamine (GO:0034776)4.10421440
34amino acid import (GO:0043090)4.08920406
35regulation of neuronal synaptic plasticity (GO:0048168)4.05156936
36potassium ion homeostasis (GO:0055075)4.01450339
37potassium ion import (GO:0010107)3.99843589
38neurotransmitter-gated ion channel clustering (GO:0072578)3.92801349
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86538347
40synaptic vesicle endocytosis (GO:0048488)3.85896005
41righting reflex (GO:0060013)3.84237963
42positive regulation of membrane potential (GO:0045838)3.84217316
43layer formation in cerebral cortex (GO:0021819)3.82911477
44long-term memory (GO:0007616)3.77039271
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.76987201
46presynaptic membrane assembly (GO:0097105)3.76368857
47regulation of postsynaptic membrane potential (GO:0060078)3.74274568
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.69455111
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68363375
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64851716
51membrane depolarization during action potential (GO:0086010)3.64460166
52cell communication by electrical coupling (GO:0010644)3.64121060
53cell differentiation in hindbrain (GO:0021533)3.62290099
54behavioral fear response (GO:0001662)3.61771164
55behavioral defense response (GO:0002209)3.61771164
56negative regulation of dendrite morphogenesis (GO:0050774)3.61753599
57proline transport (GO:0015824)3.61031992
58neuronal ion channel clustering (GO:0045161)3.59854683
59long-term synaptic potentiation (GO:0060291)3.57827633
60startle response (GO:0001964)3.56512671
61neurotransmitter transport (GO:0006836)3.55969655
62positive regulation of dendritic spine development (GO:0060999)3.53152050
63postsynaptic membrane organization (GO:0001941)3.52959033
64regulation of synaptic plasticity (GO:0048167)3.51475874
65regulation of synapse maturation (GO:0090128)3.51107089
66serotonin metabolic process (GO:0042428)3.50358089
67regulation of neurotransmitter secretion (GO:0046928)3.50079710
68gamma-aminobutyric acid transport (GO:0015812)3.49522353
69acidic amino acid transport (GO:0015800)3.48929579
70neuron recognition (GO:0008038)3.48655166
71dendritic spine morphogenesis (GO:0060997)3.44939143
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.44578145
73presynaptic membrane organization (GO:0097090)3.43614206
74central nervous system myelination (GO:0022010)3.41550200
75axon ensheathment in central nervous system (GO:0032291)3.41550200
76positive regulation of neurotransmitter transport (GO:0051590)3.40568561
77neuromuscular process controlling balance (GO:0050885)3.39625861
78fear response (GO:0042596)3.38207456
79cerebellar Purkinje cell differentiation (GO:0021702)3.33737330
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32872627
81regulation of synapse structural plasticity (GO:0051823)3.31807269
82regulation of rhodopsin mediated signaling pathway (GO:0022400)3.31293246
83positive regulation of neurotransmitter secretion (GO:0001956)3.31233110
84social behavior (GO:0035176)3.30044560
85intraspecies interaction between organisms (GO:0051703)3.30044560
86membrane hyperpolarization (GO:0060081)3.27974546
87behavioral response to cocaine (GO:0048148)3.27598900
88cerebellar Purkinje cell layer development (GO:0021680)3.27100637
89C4-dicarboxylate transport (GO:0015740)3.26398125
90regulation of ARF protein signal transduction (GO:0032012)3.26111632
91regulation of neurotransmitter transport (GO:0051588)3.24263895
92regulation of neurotransmitter levels (GO:0001505)3.23647277
93regulation of vesicle fusion (GO:0031338)3.23525497
94regulation of dendritic spine morphogenesis (GO:0061001)3.22204912
95auditory behavior (GO:0031223)3.21403937
96neurotransmitter uptake (GO:0001504)3.21231925
97neuromuscular synaptic transmission (GO:0007274)3.20747198
98neuromuscular process controlling posture (GO:0050884)3.15242947
99primary amino compound metabolic process (GO:1901160)3.14781489
100neurofilament cytoskeleton organization (GO:0060052)3.14527907
101rhodopsin mediated signaling pathway (GO:0016056)3.14225980
102cell communication involved in cardiac conduction (GO:0086065)3.13541861
103cellular potassium ion homeostasis (GO:0030007)3.12348517
104chemosensory behavior (GO:0007635)3.10972419
105axonal fasciculation (GO:0007413)3.09778084
106learning (GO:0007612)3.08952576
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08574056
108transmission of nerve impulse (GO:0019226)3.08384830
109L-glutamate transport (GO:0015813)3.07878661
110positive regulation of synaptic transmission (GO:0050806)3.02887147
111synaptic transmission (GO:0007268)3.01554162
112activation of protein kinase A activity (GO:0034199)3.01262532
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00619629
114membrane depolarization (GO:0051899)3.00317259
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99528336
116regulation of voltage-gated calcium channel activity (GO:1901385)2.99376287
117positive regulation of synapse maturation (GO:0090129)2.98551301
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.98255080
119innervation (GO:0060384)2.98077543
120regulation of synaptic transmission (GO:0050804)2.97491601
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95427465
122regulation of clathrin-mediated endocytosis (GO:2000369)2.93231924
123regulation of dendritic spine development (GO:0060998)2.91591185
124long term synaptic depression (GO:0060292)2.89903864
125positive regulation of guanylate cyclase activity (GO:0031284)2.89642509
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89598490
127positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87885939
128regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.87804040
129regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.87804040
130behavioral response to ethanol (GO:0048149)2.86482228
131synaptic vesicle transport (GO:0048489)2.84656954
132establishment of synaptic vesicle localization (GO:0097480)2.84656954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19496288
2GBX2_23144817_ChIP-Seq_PC3_Human4.08062268
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86367911
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86062704
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69434926
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.45312660
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42963593
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42963593
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40518987
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28500417
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24515926
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24196710
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23045959
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.22162792
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17332218
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.08860441
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08142324
18AR_21572438_ChIP-Seq_LNCaP_Human2.05439102
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03715268
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.02425743
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02232382
22DROSHA_22980978_ChIP-Seq_HELA_Human2.00757978
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00645258
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.99596394
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.97766551
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97553016
27TAF15_26573619_Chip-Seq_HEK293_Human1.96019107
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.93862000
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.90542883
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86800186
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85924376
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85495240
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82934749
34IGF1R_20145208_ChIP-Seq_DFB_Human1.81829877
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.79271943
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72015974
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69747015
38P300_19829295_ChIP-Seq_ESCs_Human1.68514643
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58835915
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55793453
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54652274
42VDR_22108803_ChIP-Seq_LS180_Human1.52320132
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.49785724
44STAT3_23295773_ChIP-Seq_U87_Human1.47144058
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40976126
46RNF2_27304074_Chip-Seq_NSC_Mouse1.39211394
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39179138
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39024504
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.38451214
50* FUS_26573619_Chip-Seq_HEK293_Human1.38098241
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.37814495
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37182731
53* AR_25329375_ChIP-Seq_VCAP_Human1.35526198
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34891486
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32111965
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.31029438
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30030312
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29094668
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26562220
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24338177
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23248972
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22154945
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21525974
64* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21444179
65* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21444179
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21091069
67TCF4_23295773_ChIP-Seq_U87_Human1.20479588
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19911984
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19432643
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.19203007
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17997922
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17907387
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17286811
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16787483
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16538507
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16405936
77AR_19668381_ChIP-Seq_PC3_Human1.15558004
78* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15483982
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14139790
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11759287
81* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10907208
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10294729
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.09518326
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.09078296
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08915299
86ER_23166858_ChIP-Seq_MCF-7_Human1.07177364
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06554681
88RUNX2_22187159_ChIP-Seq_PCA_Human1.06186899
89TP53_16413492_ChIP-PET_HCT116_Human1.05697494
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.05324452
91KDM2B_26808549_Chip-Seq_REH_Human1.04679553
92JUN_21703547_ChIP-Seq_K562_Human1.03298863
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.03252111
94AHR_22903824_ChIP-Seq_MCF-7_Human1.03101077
95* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02584213
96ZNF274_21170338_ChIP-Seq_K562_Hela1.02502824
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99961574
98* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99607462
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.99483584
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99420656
101E2F1_18555785_Chip-Seq_ESCs_Mouse0.98864706
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98498029
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98234474
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97337669
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97091663
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96990647
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.95912948
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.95190886
109CMYC_18555785_Chip-Seq_ESCs_Mouse0.94817288
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91841280
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.90906572
112* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89691496
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.88237080
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87855998
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87463550
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.87153518
117TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84486038
118SMAD4_21741376_ChIP-Seq_EPCs_Human0.83487204
119STAT3_18555785_ChIP-Seq_MESCs_Mouse0.82931249
120EGR1_19032775_ChIP-ChIP_M12_Human0.81905114
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81754980
122KDM2B_26808549_Chip-Seq_K562_Human0.81744700
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80357801
124SOX9_26525672_Chip-Seq_HEART_Mouse0.79708646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.00688367
2MP0003880_abnormal_central_pattern4.83544975
3MP0003635_abnormal_synaptic_transmissio4.01318019
4MP0004270_analgesia3.89923565
5MP0009745_abnormal_behavioral_response3.30844083
6MP0001968_abnormal_touch/_nociception3.28520708
7* MP0002063_abnormal_learning/memory/cond3.23029715
8MP0009046_muscle_twitch3.07214424
9MP0002064_seizures3.02603562
10MP0005423_abnormal_somatic_nervous2.91617238
11* MP0002572_abnormal_emotion/affect_behav2.89881511
12MP0002734_abnormal_mechanical_nocicepti2.85847426
13MP0002272_abnormal_nervous_system2.67729719
14MP0001486_abnormal_startle_reflex2.67433205
15MP0005551_abnormal_eye_electrophysiolog2.61241998
16MP0002736_abnormal_nociception_after2.57274942
17MP0001501_abnormal_sleep_pattern2.45890281
18MP0005646_abnormal_pituitary_gland2.11972978
19MP0001440_abnormal_grooming_behavior2.09562749
20MP0002735_abnormal_chemical_nociception2.07372168
21MP0003787_abnormal_imprinting2.03824833
22MP0002067_abnormal_sensory_capabilities1.97955663
23MP0002733_abnormal_thermal_nociception1.95375020
24MP0001970_abnormal_pain_threshold1.93809230
25MP0004924_abnormal_behavior1.88960406
26MP0005386_behavior/neurological_phenoty1.88960406
27MP0001529_abnormal_vocalization1.86095650
28MP0004147_increased_porphyrin_level1.81809641
29MP0002557_abnormal_social/conspecific_i1.79315202
30MP0003879_abnormal_hair_cell1.79037137
31MP0002184_abnormal_innervation1.77531753
32MP0006276_abnormal_autonomic_nervous1.76146445
33MP0000778_abnormal_nervous_system1.70004709
34MP0001905_abnormal_dopamine_level1.67677294
35MP0008569_lethality_at_weaning1.62993091
36MP0009780_abnormal_chondrocyte_physiolo1.62166478
37MP0003329_amyloid_beta_deposits1.58076205
38MP0002102_abnormal_ear_morphology1.56951852
39MP0001984_abnormal_olfaction1.55620167
40MP0002882_abnormal_neuron_morphology1.52471244
41MP0001502_abnormal_circadian_rhythm1.50197907
42MP0004811_abnormal_neuron_physiology1.46229017
43MP0006072_abnormal_retinal_apoptosis1.40842124
44MP0000955_abnormal_spinal_cord1.36778290
45MP0002822_catalepsy1.35338789
46MP0010386_abnormal_urinary_bladder1.35094350
47MP0002066_abnormal_motor_capabilities/c1.34247932
48MP0001188_hyperpigmentation1.32772996
49MP0003646_muscle_fatigue1.31358658
50MP0002229_neurodegeneration1.29712111
51MP0005253_abnormal_eye_physiology1.27734439
52MP0004885_abnormal_endolymph1.22027584
53MP0005171_absent_coat_pigmentation1.19829830
54MP0003690_abnormal_glial_cell1.15874908
55MP0004142_abnormal_muscle_tone1.13750856
56MP0004742_abnormal_vestibular_system1.13485013
57MP0004858_abnormal_nervous_system1.11177977
58MP0002752_abnormal_somatic_nervous1.09944560
59MP0002909_abnormal_adrenal_gland1.08475668
60MP0003045_fibrosis1.08367315
61MP0005645_abnormal_hypothalamus_physiol1.07769006
62MP0002090_abnormal_vision1.06444639
63MP0001963_abnormal_hearing_physiology1.05879894
64MP0003123_paternal_imprinting1.04802648
65MP0003633_abnormal_nervous_system1.04341913
66MP0002152_abnormal_brain_morphology1.03225010
67MP0001986_abnormal_taste_sensitivity1.02437551
68MP0008872_abnormal_physiological_respon1.02386183
69MP0008877_abnormal_DNA_methylation1.01812858
70MP0003631_nervous_system_phenotype1.01033312
71MP0003137_abnormal_impulse_conducting0.99316215
72MP0003136_yellow_coat_color0.99306714
73MP0004145_abnormal_muscle_electrophysio0.95184100
74MP0002653_abnormal_ependyma_morphology0.93646947
75MP0000631_abnormal_neuroendocrine_gland0.93352039
76MP0006292_abnormal_olfactory_placode0.90284310
77MP0000569_abnormal_digit_pigmentation0.85901452
78MP0003122_maternal_imprinting0.84978017
79MP0005195_abnormal_posterior_eye0.84686023
80MP0002876_abnormal_thyroid_physiology0.84443559
81MP0002638_abnormal_pupillary_reflex0.83264071
82MP0003632_abnormal_nervous_system0.82260870
83MP0003011_delayed_dark_adaptation0.81290643
84MP0002069_abnormal_eating/drinking_beha0.81198874
85MP0008874_decreased_physiological_sensi0.80919121
86MP0003890_abnormal_embryonic-extraembry0.79595440
87MP0004043_abnormal_pH_regulation0.78497869
88MP0004484_altered_response_of0.77642228
89MP0005167_abnormal_blood-brain_barrier0.74266612
90MP0005535_abnormal_body_temperature0.73556447
91MP0004510_myositis0.72899752
92MP0004085_abnormal_heartbeat0.70461889
93MP0002837_dystrophic_cardiac_calcinosis0.69152998
94MP0000026_abnormal_inner_ear0.68462990
95MP0001348_abnormal_lacrimal_gland0.68088687
96MP0000751_myopathy0.67647213
97MP0001664_abnormal_digestion0.66433659
98MP0003121_genomic_imprinting0.64831164
99MP0003634_abnormal_glial_cell0.60813571
100MP0001177_atelectasis0.60145737
101MP0005499_abnormal_olfactory_system0.59534678
102MP0005394_taste/olfaction_phenotype0.59534678
103MP0004215_abnormal_myocardial_fiber0.58068313
104MP0001485_abnormal_pinna_reflex0.57321134
105MP0005623_abnormal_meninges_morphology0.55411278
106MP0000920_abnormal_myelination0.54408154
107MP0003861_abnormal_nervous_system0.53250734
108MP0004233_abnormal_muscle_weight0.52096610
109MP0003283_abnormal_digestive_organ0.52086483
110MP0008004_abnormal_stomach_pH0.50683245
111MP0004130_abnormal_muscle_cell0.50558286
112MP0000604_amyloidosis0.49883793
113MP0005187_abnormal_penis_morphology0.49664710
114MP0006035_abnormal_mitochondrial_morpho0.48958361
115MP0010769_abnormal_survival0.48556306
116MP0008875_abnormal_xenobiotic_pharmacok0.47897710
117MP0003956_abnormal_body_size0.46812444
118MP0000566_synostosis0.46313765
119MP0010768_mortality/aging0.45621536
120MP0003075_altered_response_to0.44405828

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.64939569
2Myokymia (HP:0002411)5.86861608
3Dyschromatopsia (HP:0007641)5.53911765
4Epileptic encephalopathy (HP:0200134)5.32316603
5Focal seizures (HP:0007359)5.29223487
6Febrile seizures (HP:0002373)4.76430082
7Atonic seizures (HP:0010819)4.66536771
8Visual hallucinations (HP:0002367)4.47354623
9Abnormality of macular pigmentation (HP:0008002)4.41432226
10Progressive cerebellar ataxia (HP:0002073)4.15756336
11Absence seizures (HP:0002121)3.93397484
12Broad-based gait (HP:0002136)3.90905961
13Hyperventilation (HP:0002883)3.86723418
14Generalized tonic-clonic seizures (HP:0002069)3.80230962
15Bony spicule pigmentary retinopathy (HP:0007737)3.60931850
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.56506967
17Congenital stationary night blindness (HP:0007642)3.53097100
18Dialeptic seizures (HP:0011146)3.49620601
19Abnormal rod and cone electroretinograms (HP:0008323)3.38769654
20Central scotoma (HP:0000603)3.22532809
21Gaze-evoked nystagmus (HP:0000640)3.15741242
22Mutism (HP:0002300)3.09996613
23Dysdiadochokinesis (HP:0002075)3.04779058
24Hemiplegia (HP:0002301)2.98055546
25Poor eye contact (HP:0000817)2.97488848
26Impaired vibration sensation in the lower limbs (HP:0002166)2.97378564
27Decreased central vision (HP:0007663)2.94660735
28Dysmetria (HP:0001310)2.91615032
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.88269979
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88269979
31Supranuclear gaze palsy (HP:0000605)2.85478032
32Cerebral hypomyelination (HP:0006808)2.83002561
33Genetic anticipation (HP:0003743)2.82070141
34Gait imbalance (HP:0002141)2.82011113
35Urinary bladder sphincter dysfunction (HP:0002839)2.81561203
36Progressive inability to walk (HP:0002505)2.81438279
37Action tremor (HP:0002345)2.76704565
38Drooling (HP:0002307)2.74509808
39Excessive salivation (HP:0003781)2.74509808
40Inability to walk (HP:0002540)2.74311840
41Truncal ataxia (HP:0002078)2.71782581
42Tetraplegia (HP:0002445)2.69352996
43Peripheral hypomyelination (HP:0007182)2.68532257
44Absent speech (HP:0001344)2.68002488
45Abnormal eating behavior (HP:0100738)2.64196045
46Amblyopia (HP:0000646)2.63266071
47Attenuation of retinal blood vessels (HP:0007843)2.59841499
48Fetal akinesia sequence (HP:0001989)2.59825103
49Annular pancreas (HP:0001734)2.57172399
50Postural instability (HP:0002172)2.54600647
51Scanning speech (HP:0002168)2.53077412
52Ankle clonus (HP:0011448)2.50067970
53Craniofacial dystonia (HP:0012179)2.49995008
54Abnormality of saccadic eye movements (HP:0000570)2.49390477
55Impaired social interactions (HP:0000735)2.49368550
56Abnormal social behavior (HP:0012433)2.49368550
57Choroideremia (HP:0001139)2.48013418
58Postural tremor (HP:0002174)2.47648997
59Scotoma (HP:0000575)2.43472117
60Congenital primary aphakia (HP:0007707)2.43034904
61Papilledema (HP:0001085)2.41356926
62Obstructive sleep apnea (HP:0002870)2.41059567
63Neuronal loss in central nervous system (HP:0002529)2.40789939
64Anxiety (HP:0000739)2.38772897
65Depression (HP:0000716)2.36398698
66Epileptiform EEG discharges (HP:0011182)2.35861209
67Delusions (HP:0000746)2.33055306
68Generalized myoclonic seizures (HP:0002123)2.31665310
69Impaired smooth pursuit (HP:0007772)2.30431193
70Morphological abnormality of the pyramidal tract (HP:0002062)2.28744451
71Torticollis (HP:0000473)2.28511914
72Sleep apnea (HP:0010535)2.28443223
73Polyphagia (HP:0002591)2.26297128
74Gait ataxia (HP:0002066)2.24163678
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.22886155
76Nephrogenic diabetes insipidus (HP:0009806)2.20792097
77Clonus (HP:0002169)2.20520072
78Neurofibrillary tangles (HP:0002185)2.19498640
79Abnormality of the corticospinal tract (HP:0002492)2.18816210
80Akinesia (HP:0002304)2.18591822
81Photophobia (HP:0000613)2.17869626
82Spastic gait (HP:0002064)2.17696799
83Medial flaring of the eyebrow (HP:0010747)2.17409317
84EEG with generalized epileptiform discharges (HP:0011198)2.14618719
85Abnormality of binocular vision (HP:0011514)2.13912496
86Diplopia (HP:0000651)2.13912496
87CNS hypomyelination (HP:0003429)2.13086167
88Ulnar claw (HP:0001178)2.10740752
89Hemiparesis (HP:0001269)2.08875337
90Protruding tongue (HP:0010808)2.08618053
91Stereotypic behavior (HP:0000733)2.08601459
92Cerebral inclusion bodies (HP:0100314)2.07577001
93Apathy (HP:0000741)2.06311717
94Limb dystonia (HP:0002451)2.06307167
95Rigidity (HP:0002063)2.06239518
96Urinary urgency (HP:0000012)2.05935367
97Limb ataxia (HP:0002070)2.05347804
98Specific learning disability (HP:0001328)2.04495321
99Amelogenesis imperfecta (HP:0000705)2.03495451
100Impaired vibratory sensation (HP:0002495)2.03296254
101Focal dystonia (HP:0004373)2.02840955
102Abnormality of ocular smooth pursuit (HP:0000617)2.01888856
103Pendular nystagmus (HP:0012043)1.99362325
104Genital tract atresia (HP:0001827)1.99145774
105Termporal pattern (HP:0011008)1.97950327
106Insidious onset (HP:0003587)1.97950327
107Spastic tetraparesis (HP:0001285)1.97831311
108Abnormality of the lower motor neuron (HP:0002366)1.97308349
109Inappropriate behavior (HP:0000719)1.96230277
110Hypsarrhythmia (HP:0002521)1.95834373
111Intention tremor (HP:0002080)1.94834652
112Choreoathetosis (HP:0001266)1.94811812
113Vaginal atresia (HP:0000148)1.92501508
114Dysmetric saccades (HP:0000641)1.91300193
115Generalized hypopigmentation of hair (HP:0011358)1.90823166
116Bradykinesia (HP:0002067)1.90636080
117Abnormality of salivation (HP:0100755)1.87986824
118Diminished motivation (HP:0000745)1.87644807
119Horizontal nystagmus (HP:0000666)1.87233273
120Poor coordination (HP:0002370)1.87146871
121Status epilepticus (HP:0002133)1.86330352
122Pigmentary retinal degeneration (HP:0001146)1.86314110
123Rapidly progressive (HP:0003678)1.85427533
124Amyotrophic lateral sclerosis (HP:0007354)1.83741881
125Widely spaced teeth (HP:0000687)1.82203699
126Blue irides (HP:0000635)1.80881420
127Fair hair (HP:0002286)1.80087755
128Incomplete penetrance (HP:0003829)1.78536316
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.78070340
130Absent/shortened dynein arms (HP:0200106)1.78070340
131Lower limb muscle weakness (HP:0007340)1.77568890
132Bundle branch block (HP:0011710)1.77076706
133Dysarthria (HP:0001260)1.74140069
134Spastic tetraplegia (HP:0002510)1.73728915
135Memory impairment (HP:0002354)1.69630622
136Prolonged QT interval (HP:0001657)1.65972427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.04411462
2NTRK33.97192767
3MAP3K93.71995926
4MAP3K43.60188145
5MAP2K73.24189615
6CASK3.03912784
7MARK12.58132733
8KSR22.25525929
9LATS12.23526332
10PAK62.13842138
11MAP3K122.09378121
12MUSK2.09139475
13DAPK22.08769393
14RIPK42.07627839
15MINK12.05197273
16MAP2K42.04953005
17NTRK22.04091596
18MAP3K61.98784702
19STK38L1.88174995
20MAPK131.86152414
21CDK191.83253185
22PLK21.79336847
23ARAF1.66698653
24KSR11.61171978
25MAP3K131.60614222
26PRKD31.51043165
27TNIK1.47068888
28LATS21.44731422
29DAPK11.43144890
30TAOK11.40209708
31CDK51.34645406
32GRK51.30377719
33BMPR21.27006613
34RAF11.25556811
35BRAF1.23804960
36STK381.20540503
37NTRK11.19170962
38CAMKK11.15806772
39CAMK2A1.14708814
40PNCK1.07843661
41SIK21.06942460
42SGK2230.97723763
43SGK4940.97723763
44OXSR10.97640141
45PRPF4B0.95411658
46PRKCG0.94934029
47SGK20.93324793
48CCNB10.91258919
49FES0.88881937
50CDK180.85067201
51RIPK10.83698677
52CDK150.82363999
53WNK10.81323898
54CSNK1G20.81009776
55TYRO30.77118142
56CDK140.76677807
57FGR0.76108175
58RET0.74811781
59CDK30.74697943
60CAMK10.73685019
61CDK11A0.73462911
62ERBB40.73437122
63MAPKAPK50.73007472
64STK110.70539584
65CSNK1A1L0.68249701
66CDK80.68234271
67UHMK10.68194561
68CAMK2B0.66995799
69MARK20.65990527
70CAMKK20.65619417
71SGK30.65347751
72PINK10.64326973
73CAMK40.62859060
74SIK30.62247941
75SGK10.61614586
76BMPR1B0.60275654
77MAPK120.58752031
78MAP3K110.58723482
79DYRK1A0.56508989
80GRK10.55413071
81NEK60.55092827
82PAK30.54265758
83AKT30.53367852
84ALK0.52633204
85PDK10.51771519
86PKN10.51641034
87LIMK10.51592517
88PTK2B0.51160690
89ACVR1B0.51103507
90PRKCH0.50341513
91PRKCE0.50002679
92PHKG20.49088439
93PHKG10.49088439
94MOS0.46676573
95MAP3K20.46567821
96BCR0.45665884
97PDPK10.45424941
98DAPK30.43772261
99RPS6KA30.42850265
100PRKD20.42358752
101PRKCZ0.40674173
102MAPK100.39720819
103FYN0.39594028
104CSNK1G30.39315814
105CSNK1D0.38378111
106PRKG10.38305939
107ADRBK10.37644338
108CAMK2D0.37069976
109PRKG20.36681983
110PRKCA0.36354998
111MAP3K10.35290074
112BRSK10.33909749
113ROCK20.33298432
114CAMK2G0.32788586
115DYRK20.32099684
116MAPK70.31151343
117DMPK0.31064027
118WNK30.29183583
119TNK20.29114472
120GRK70.28889644
121TESK10.28832521
122CSNK1A10.28086382
123PRKACA0.27732241
124MAP2K10.27210911

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.31091040
2Nicotine addiction_Homo sapiens_hsa050333.81255425
3Synaptic vesicle cycle_Homo sapiens_hsa047213.25427065
4Olfactory transduction_Homo sapiens_hsa047402.79520761
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78144530
6Glutamatergic synapse_Homo sapiens_hsa047242.75223010
7GABAergic synapse_Homo sapiens_hsa047272.65445611
8Long-term potentiation_Homo sapiens_hsa047202.61877290
9Circadian entrainment_Homo sapiens_hsa047132.60205082
10Morphine addiction_Homo sapiens_hsa050322.47641979
11Amphetamine addiction_Homo sapiens_hsa050312.31523472
12Salivary secretion_Homo sapiens_hsa049702.12922236
13Dopaminergic synapse_Homo sapiens_hsa047282.11582087
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02572883
15* Serotonergic synapse_Homo sapiens_hsa047261.89505503
16Insulin secretion_Homo sapiens_hsa049111.87953027
17Long-term depression_Homo sapiens_hsa047301.84573217
18Cholinergic synapse_Homo sapiens_hsa047251.83517558
19Taste transduction_Homo sapiens_hsa047421.83327108
20Gastric acid secretion_Homo sapiens_hsa049711.70065426
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69804890
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69724741
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64394110
24GnRH signaling pathway_Homo sapiens_hsa049121.61843036
25Renin secretion_Homo sapiens_hsa049241.58499454
26Collecting duct acid secretion_Homo sapiens_hsa049661.53966174
27* Calcium signaling pathway_Homo sapiens_hsa040201.51152590
28Cocaine addiction_Homo sapiens_hsa050301.48056461
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37151400
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31943132
31cAMP signaling pathway_Homo sapiens_hsa040241.27055342
32Gap junction_Homo sapiens_hsa045401.23004190
33* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21143716
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12088148
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09163673
36Vitamin B6 metabolism_Homo sapiens_hsa007501.05709917
37Estrogen signaling pathway_Homo sapiens_hsa049151.04563700
38Axon guidance_Homo sapiens_hsa043601.03550237
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03295045
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02530631
41ErbB signaling pathway_Homo sapiens_hsa040121.02064682
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01621344
43Dorso-ventral axis formation_Homo sapiens_hsa043201.00726012
44Oocyte meiosis_Homo sapiens_hsa041141.00098109
45Glioma_Homo sapiens_hsa052140.99271356
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98868885
47Ovarian steroidogenesis_Homo sapiens_hsa049130.96449195
48Circadian rhythm_Homo sapiens_hsa047100.95121419
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.94092124
50Melanogenesis_Homo sapiens_hsa049160.93140872
51Nitrogen metabolism_Homo sapiens_hsa009100.91636074
52Type II diabetes mellitus_Homo sapiens_hsa049300.89051879
53Choline metabolism in cancer_Homo sapiens_hsa052310.87078206
54Vibrio cholerae infection_Homo sapiens_hsa051100.83004469
55Bile secretion_Homo sapiens_hsa049760.80700906
56MAPK signaling pathway_Homo sapiens_hsa040100.80398914
57Cardiac muscle contraction_Homo sapiens_hsa042600.79822026
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.79052583
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77193409
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76543558
61Ras signaling pathway_Homo sapiens_hsa040140.76527847
62Type I diabetes mellitus_Homo sapiens_hsa049400.67305284
63Pancreatic secretion_Homo sapiens_hsa049720.67285879
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67002680
65VEGF signaling pathway_Homo sapiens_hsa043700.63175732
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63145614
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61299321
68Dilated cardiomyopathy_Homo sapiens_hsa054140.60629954
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60064530
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59685158
71Thyroid hormone synthesis_Homo sapiens_hsa049180.56050460
72African trypanosomiasis_Homo sapiens_hsa051430.56010124
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53614137
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.51856590
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51828518
76Inositol phosphate metabolism_Homo sapiens_hsa005620.49996857
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.48866165
78Wnt signaling pathway_Homo sapiens_hsa043100.48762024
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48545858
80Rap1 signaling pathway_Homo sapiens_hsa040150.46296670
81Prion diseases_Homo sapiens_hsa050200.46211581
82Renal cell carcinoma_Homo sapiens_hsa052110.42069847
83Ether lipid metabolism_Homo sapiens_hsa005650.41348867
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41156036
85Glucagon signaling pathway_Homo sapiens_hsa049220.40555290
86Colorectal cancer_Homo sapiens_hsa052100.40312099
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39606464
88Rheumatoid arthritis_Homo sapiens_hsa053230.39063472
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38247538
90mTOR signaling pathway_Homo sapiens_hsa041500.36973102
91Arginine and proline metabolism_Homo sapiens_hsa003300.36373310
92Non-small cell lung cancer_Homo sapiens_hsa052230.35565520
93Alcoholism_Homo sapiens_hsa050340.35416537
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34165114
95Histidine metabolism_Homo sapiens_hsa003400.33828667
96Fatty acid biosynthesis_Homo sapiens_hsa000610.33614547
97Alzheimers disease_Homo sapiens_hsa050100.32860949
98Prolactin signaling pathway_Homo sapiens_hsa049170.31852956
99Chemokine signaling pathway_Homo sapiens_hsa040620.31729440
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30713674
101Endometrial cancer_Homo sapiens_hsa052130.30454498
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.30345588
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29761117
104Oxidative phosphorylation_Homo sapiens_hsa001900.28413324
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28272723
106Endocytosis_Homo sapiens_hsa041440.28185162
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27572772
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26153423
109Mineral absorption_Homo sapiens_hsa049780.26131614
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25067192
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24833085
112Arginine biosynthesis_Homo sapiens_hsa002200.24739605
113Phenylalanine metabolism_Homo sapiens_hsa003600.24597823
114Sphingolipid metabolism_Homo sapiens_hsa006000.21431132
115ABC transporters_Homo sapiens_hsa020100.16124265
116Parkinsons disease_Homo sapiens_hsa050120.14234785
117beta-Alanine metabolism_Homo sapiens_hsa004100.13107155
118Hippo signaling pathway_Homo sapiens_hsa043900.12955982

Most similar genes based on co-expression Upload to Enrichr

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