HTR3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mast cell activation (GO:0033004)5.28854131
2neuron cell-cell adhesion (GO:0007158)5.03321979
3synaptic vesicle endocytosis (GO:0048488)4.94156982
4negative regulation of dendrite morphogenesis (GO:0050774)4.86847140
5presynaptic membrane assembly (GO:0097105)4.82047033
6vocalization behavior (GO:0071625)4.23959548
7inner ear receptor stereocilium organization (GO:0060122)4.21857279
8sympathetic nervous system development (GO:0048485)4.12522191
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11148579
10cornea development in camera-type eye (GO:0061303)4.07651480
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.02253374
12fucose catabolic process (GO:0019317)3.94129846
13L-fucose metabolic process (GO:0042354)3.94129846
14L-fucose catabolic process (GO:0042355)3.94129846
15postsynaptic membrane organization (GO:0001941)3.93094630
16tryptophan catabolic process (GO:0006569)3.91126727
17indole-containing compound catabolic process (GO:0042436)3.91126727
18indolalkylamine catabolic process (GO:0046218)3.91126727
19presynaptic membrane organization (GO:0097090)3.89437732
20negative regulation of stem cell proliferation (GO:2000647)3.88945992
21polyketide metabolic process (GO:0030638)3.84974228
22doxorubicin metabolic process (GO:0044598)3.84974228
23daunorubicin metabolic process (GO:0044597)3.84974228
24behavioral response to nicotine (GO:0035095)3.78870157
25negative regulation of dendrite development (GO:2000171)3.78764459
26axoneme assembly (GO:0035082)3.78524821
27detection of light stimulus involved in visual perception (GO:0050908)3.75233882
28detection of light stimulus involved in sensory perception (GO:0050962)3.75233882
29response to pheromone (GO:0019236)3.73734850
30indolalkylamine metabolic process (GO:0006586)3.73021592
31limb bud formation (GO:0060174)3.70757739
32kynurenine metabolic process (GO:0070189)3.68732813
33auditory receptor cell stereocilium organization (GO:0060088)3.67928726
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.63221539
35central nervous system projection neuron axonogenesis (GO:0021952)3.59275813
36regulation of cilium movement (GO:0003352)3.58206557
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56675855
38startle response (GO:0001964)3.55965769
39piRNA metabolic process (GO:0034587)3.54794228
40gamma-aminobutyric acid transport (GO:0015812)3.52859744
41neural tube formation (GO:0001841)3.51051172
42developmental pigmentation (GO:0048066)3.50032728
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46927863
44ganglion development (GO:0061548)3.41826813
45behavioral response to ethanol (GO:0048149)3.40467751
46glial cell proliferation (GO:0014009)3.40068702
47hindbrain development (GO:0030902)3.37119798
48amine catabolic process (GO:0009310)3.31502425
49cellular biogenic amine catabolic process (GO:0042402)3.31502425
50DNA deamination (GO:0045006)3.30945631
51water-soluble vitamin biosynthetic process (GO:0042364)3.26126599
52regulation of DNA endoreduplication (GO:0032875)3.26048232
53cerebral cortex radially oriented cell migration (GO:0021799)3.24152267
54platelet dense granule organization (GO:0060155)3.23761223
55photoreceptor cell maintenance (GO:0045494)3.23394031
56negative regulation of homotypic cell-cell adhesion (GO:0034111)3.23130724
57epithelial cilium movement (GO:0003351)3.21734246
58cellular ketone body metabolic process (GO:0046950)3.17854870
59central nervous system neuron axonogenesis (GO:0021955)3.15825959
60protein localization to microtubule cytoskeleton (GO:0072698)3.14178675
61tryptophan metabolic process (GO:0006568)3.13589087
62extracellular negative regulation of signal transduction (GO:1900116)3.13476999
63extracellular regulation of signal transduction (GO:1900115)3.13476999
64regulation of timing of cell differentiation (GO:0048505)3.12307613
65negative regulation of telomere maintenance (GO:0032205)3.11388019
66opioid receptor signaling pathway (GO:0038003)3.11192530
67detection of molecule of bacterial origin (GO:0032490)3.07501582
68negative regulation of glycogen metabolic process (GO:0070874)3.04539802
69positive regulation of cellular amide metabolic process (GO:0034250)3.03224317
70protein localization to microtubule (GO:0035372)3.02640254
71lung secretory cell differentiation (GO:0061140)2.99908668
72ubiquinone biosynthetic process (GO:0006744)2.98695944
73superoxide anion generation (GO:0042554)2.98513755
74preassembly of GPI anchor in ER membrane (GO:0016254)2.97407068
75protein polyglutamylation (GO:0018095)2.95987962
76histone H3-K4 trimethylation (GO:0080182)2.95182008
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94504164
78DNA methylation involved in gamete generation (GO:0043046)2.93684481
79indole-containing compound metabolic process (GO:0042430)2.93487170
80protein K11-linked deubiquitination (GO:0035871)2.92441571
81regulation of glucokinase activity (GO:0033131)2.91367184
82regulation of hexokinase activity (GO:1903299)2.91367184
83reflex (GO:0060004)2.91219457
84cardiac chamber formation (GO:0003207)2.91055400
85adenosine metabolic process (GO:0046085)2.90586034
86ketone body metabolic process (GO:1902224)2.89106115
87facial nerve structural organization (GO:0021612)2.87135920
88regulation of neurotransmitter uptake (GO:0051580)2.87073639
89mesenchymal cell differentiation involved in kidney development (GO:0072161)2.86630220
90mesenchymal cell differentiation involved in renal system development (GO:2001012)2.86630220
91cilium morphogenesis (GO:0060271)2.85823468
92cardiac ventricle formation (GO:0003211)2.85103295
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84596578
94regulation of respiratory system process (GO:0044065)2.81053044
95cytochrome complex assembly (GO:0017004)2.80410391
96establishment of protein localization to Golgi (GO:0072600)2.78805866
97synaptic transmission, glutamatergic (GO:0035249)2.77724661
98establishment of synaptic vesicle localization (GO:0097480)2.77117256
99synaptic vesicle transport (GO:0048489)2.77117256
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76985018
101nonmotile primary cilium assembly (GO:0035058)2.76361179
102negative regulation of glycogen biosynthetic process (GO:0045719)2.76308900
103ubiquinone metabolic process (GO:0006743)2.76107387
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75227003
105negative regulation of cAMP-mediated signaling (GO:0043951)2.74832191
106phagosome maturation (GO:0090382)2.74020009
107regulation of action potential (GO:0098900)2.73251748
108protein localization to cytoskeleton (GO:0044380)2.71642821
109multicellular organism reproduction (GO:0032504)2.69833011
110positive regulation of mitochondrial fission (GO:0090141)2.67406469
111neuron-neuron synaptic transmission (GO:0007270)2.66955291
112centriole replication (GO:0007099)2.66403878
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.65358623
114regulation of development, heterochronic (GO:0040034)2.65244043
115synaptic transmission, cholinergic (GO:0007271)2.65120627
116primary amino compound metabolic process (GO:1901160)2.64861248
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63535808
118sperm motility (GO:0030317)2.62288935
119lens fiber cell differentiation (GO:0070306)2.62029104
120positive regulation of synapse assembly (GO:0051965)2.61724696
121kidney morphogenesis (GO:0060993)2.60092362
122cilium organization (GO:0044782)2.58828393
123serotonin metabolic process (GO:0042428)2.58750328
124photoreceptor cell development (GO:0042461)2.58268520
125pyrimidine nucleobase catabolic process (GO:0006208)2.58246596
126cilium movement (GO:0003341)2.56955791
127regulation of glutamate receptor signaling pathway (GO:1900449)2.56633239
128protein localization to Golgi apparatus (GO:0034067)2.55509459
129inositol phosphate catabolic process (GO:0071545)2.54664130
130replication fork processing (GO:0031297)2.54420874
131detection of other organism (GO:0098543)2.53987741
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53685976
133cilium assembly (GO:0042384)2.53169497
134adaptation of signaling pathway (GO:0023058)2.52474963
135cranial nerve structural organization (GO:0021604)2.51933799
136membrane assembly (GO:0071709)2.50884582
137retinal cone cell development (GO:0046549)2.50755755
138regulation of respiratory gaseous exchange (GO:0043576)2.50534697
139adrenergic receptor signaling pathway (GO:0071875)2.50204396
140nucleobase catabolic process (GO:0046113)2.49924647
141phosphatidylserine acyl-chain remodeling (GO:0036150)2.49578578
142proline transport (GO:0015824)2.49354914
143regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48260441
144regulation of cell communication by electrical coupling (GO:0010649)2.47888162
145sulfation (GO:0051923)2.47724290
146arginine catabolic process (GO:0006527)2.47124408
147cilium or flagellum-dependent cell motility (GO:0001539)2.47083408
148regulation of platelet aggregation (GO:0090330)2.47038842
149neurotransmitter-gated ion channel clustering (GO:0072578)2.46818072
150rhodopsin mediated signaling pathway (GO:0016056)2.46304274
151regulation of microtubule-based movement (GO:0060632)2.45741710
152GPI anchor metabolic process (GO:0006505)2.45662148
153prostate gland growth (GO:0060736)2.45217212
154calcium ion import (GO:0070509)2.45153653
155transmission of nerve impulse (GO:0019226)2.44759742
156neuronal action potential propagation (GO:0019227)2.44241987
157neurofilament cytoskeleton organization (GO:0060052)2.44108513
158membrane depolarization during action potential (GO:0086010)2.43718117
159transferrin transport (GO:0033572)2.43217347
160protein targeting to Golgi (GO:0000042)2.42804631
161protein complex biogenesis (GO:0070271)2.42174900
162mannosylation (GO:0097502)2.41755917
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.41608421
164regulation of hippo signaling (GO:0035330)2.41428699
165DNA double-strand break processing (GO:0000729)2.41193136
166dopamine transport (GO:0015872)2.40950128
167regulation of meiosis I (GO:0060631)2.40806998
168quinone biosynthetic process (GO:1901663)2.40730538
169regulation of pigment cell differentiation (GO:0050932)2.40517340
170respiratory chain complex IV assembly (GO:0008535)2.40207114
171glycosphingolipid biosynthetic process (GO:0006688)2.39518533
172anterograde synaptic vesicle transport (GO:0048490)2.39337774
173calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39081005
174sequestering of extracellular ligand from receptor (GO:0035581)2.38913337
175embryonic epithelial tube formation (GO:0001838)2.38654828
176regulation of telomere maintenance (GO:0032204)2.38595250
177cAMP catabolic process (GO:0006198)2.38426146
178neuromuscular synaptic transmission (GO:0007274)2.37552364
179protein-cofactor linkage (GO:0018065)2.37141577
180G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.36870026
181reciprocal meiotic recombination (GO:0007131)2.36462860
182reciprocal DNA recombination (GO:0035825)2.36462860
183regulation of synapse assembly (GO:0051963)2.35127931
184* serotonin receptor signaling pathway (GO:0007210)2.35120512
185vesicle docking involved in exocytosis (GO:0006904)2.33696576
186neuronal action potential (GO:0019228)2.33532178
187pigment granule localization (GO:0051875)2.32472467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.17705144
2ZNF274_21170338_ChIP-Seq_K562_Hela3.96523264
3EZH2_22144423_ChIP-Seq_EOC_Human3.76424911
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.09839003
5IGF1R_20145208_ChIP-Seq_DFB_Human3.03163053
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.95987431
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84748047
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83433544
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.55864130
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52284495
11TAF15_26573619_Chip-Seq_HEK293_Human2.41895903
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39697372
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.24313349
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15148311
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12344146
16P300_19829295_ChIP-Seq_ESCs_Human2.11601177
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03383940
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01651021
19SMAD4_21799915_ChIP-Seq_A2780_Human1.98332605
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97085246
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94130175
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.93571827
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89815274
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89275752
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87269828
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85710214
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85117109
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.78203006
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.78092833
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.77174631
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75748834
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73567284
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.73016419
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.72134141
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72117506
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71983370
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70088617
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69169578
39P53_22387025_ChIP-Seq_ESCs_Mouse1.68861138
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68791056
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63605252
42BCAT_22108803_ChIP-Seq_LS180_Human1.60950560
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60602777
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60490978
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.60152779
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60055714
47CBP_20019798_ChIP-Seq_JUKART_Human1.60055714
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59575014
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59575014
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.57127861
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.55207385
52STAT3_18555785_Chip-Seq_ESCs_Mouse1.54876778
53FUS_26573619_Chip-Seq_HEK293_Human1.54143019
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.53977897
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.53154121
56RNF2_27304074_Chip-Seq_NSC_Mouse1.51205494
57ER_23166858_ChIP-Seq_MCF-7_Human1.50922466
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50705463
59REST_21632747_ChIP-Seq_MESCs_Mouse1.50015704
60TP53_22573176_ChIP-Seq_HFKS_Human1.49945589
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49762133
62AR_25329375_ChIP-Seq_VCAP_Human1.49663904
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48075288
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47402974
65JUN_21703547_ChIP-Seq_K562_Human1.46992884
66EWS_26573619_Chip-Seq_HEK293_Human1.46414787
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46207553
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43695954
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.42628869
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42404711
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.40482262
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39748719
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38258527
74SOX2_18555785_Chip-Seq_ESCs_Mouse1.37986407
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37265831
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37023724
77NANOG_19829295_ChIP-Seq_ESCs_Human1.34776960
78SOX2_19829295_ChIP-Seq_ESCs_Human1.34776960
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.34098519
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34053931
81P300_18555785_Chip-Seq_ESCs_Mouse1.33354700
82* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33295772
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33090528
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.32679183
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.31869658
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30954401
87TCF4_22108803_ChIP-Seq_LS180_Human1.30790796
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30228314
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30131576
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30036682
91STAT3_23295773_ChIP-Seq_U87_Human1.29873497
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29807318
93TCF4_23295773_ChIP-Seq_U87_Human1.28634935
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27895815
95VDR_22108803_ChIP-Seq_LS180_Human1.26827274
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23443183
97GATA3_21878914_ChIP-Seq_MCF-7_Human1.23255201
98ZFX_18555785_Chip-Seq_ESCs_Mouse1.23227926
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.23108911
100* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22639328
101* FOXA1_25329375_ChIP-Seq_VCAP_Human1.22639328
102BP1_19119308_ChIP-ChIP_Hs578T_Human1.22462176
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.22284846
104PU1_27457419_Chip-Seq_LIVER_Mouse1.22203864
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21655823
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.20033517
107CDX2_22108803_ChIP-Seq_LS180_Human1.18310681
108IRF1_19129219_ChIP-ChIP_H3396_Human1.18110781
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.17823028
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17000808
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.16338310
112TP53_18474530_ChIP-ChIP_U2OS_Human1.15908855
113ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15856318
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.15721845
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15676600
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15586332
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15518052
118RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15461200
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14954603
120NCOR_22424771_ChIP-Seq_293T_Human1.13878715
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13663137
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13057715
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13046961
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12829456
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12539028
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12239142
127HOXB7_26014856_ChIP-Seq_BT474_Human1.10851459
128GABP_17652178_ChIP-ChIP_JURKAT_Human1.10834842
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.09682282
130KDM2B_26808549_Chip-Seq_REH_Human1.09508829
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08513481
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08513481
133ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08279180
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07877380
135SOX9_26525672_Chip-Seq_HEART_Mouse1.07801635
136* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06312557
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03409656
138TP53_16413492_ChIP-PET_HCT116_Human1.02019898
139MYC_18940864_ChIP-ChIP_HL60_Human0.95376142
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95166609
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95018742
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.94002882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.64323437
2MP0006292_abnormal_olfactory_placode4.29805080
3MP0002638_abnormal_pupillary_reflex3.95073333
4MP0000569_abnormal_digit_pigmentation3.43751325
5MP0005257_abnormal_intraocular_pressure3.26995873
6MP0002735_abnormal_chemical_nociception3.04868625
7MP0000015_abnormal_ear_pigmentation2.98253658
8MP0003195_calcinosis2.86328167
9MP0001188_hyperpigmentation2.82960580
10MP0005551_abnormal_eye_electrophysiolog2.80413929
11MP0005646_abnormal_pituitary_gland2.79155618
12MP0006276_abnormal_autonomic_nervous2.60461267
13MP0005171_absent_coat_pigmentation2.54709660
14MP0002736_abnormal_nociception_after2.42248051
15MP0009697_abnormal_copulation2.40901060
16MP0005174_abnormal_tail_pigmentation2.33436994
17MP0002876_abnormal_thyroid_physiology2.31373520
18MP0001529_abnormal_vocalization2.30218681
19MP0010386_abnormal_urinary_bladder2.26172874
20MP0001968_abnormal_touch/_nociception2.24965605
21MP0001984_abnormal_olfaction2.15667530
22MP0002102_abnormal_ear_morphology2.13097396
23MP0002837_dystrophic_cardiac_calcinosis2.12390353
24MP0003880_abnormal_central_pattern2.09292962
25MP0008872_abnormal_physiological_respon2.06894055
26MP0001986_abnormal_taste_sensitivity2.03093611
27MP0004885_abnormal_endolymph1.97640234
28MP0009745_abnormal_behavioral_response1.84859188
29MP0002822_catalepsy1.79437555
30MP0008875_abnormal_xenobiotic_pharmacok1.75180875
31MP0003121_genomic_imprinting1.71968063
32MP0004859_abnormal_synaptic_plasticity1.70268743
33MP0000427_abnormal_hair_cycle1.69677648
34MP0006072_abnormal_retinal_apoptosis1.69531914
35MP0002734_abnormal_mechanical_nocicepti1.68188700
36MP0000778_abnormal_nervous_system1.65184374
37MP0005253_abnormal_eye_physiology1.64907869
38MP0002572_abnormal_emotion/affect_behav1.64529857
39MP0008260_abnormal_autophagy1.63432202
40MP0000372_irregular_coat_pigmentation1.62434042
41MP0009046_muscle_twitch1.60024417
42MP0003635_abnormal_synaptic_transmissio1.57784110
43MP0005075_abnormal_melanosome_morpholog1.57321250
44MP0003172_abnormal_lysosome_physiology1.56698521
45MP0002063_abnormal_learning/memory/cond1.55548385
46MP0004133_heterotaxia1.54372940
47MP0002938_white_spotting1.51703887
48MP0005645_abnormal_hypothalamus_physiol1.48872091
49MP0004858_abnormal_nervous_system1.44968226
50MP0002751_abnormal_autonomic_nervous1.44615515
51MP0004043_abnormal_pH_regulation1.43223617
52MP0002064_seizures1.42895767
53MP0002184_abnormal_innervation1.42883828
54MP0008057_abnormal_DNA_replication1.42688641
55MP0004270_analgesia1.41263232
56MP0001177_atelectasis1.41126269
57MP0001970_abnormal_pain_threshold1.35372763
58MP0003183_abnormal_peptide_metabolism1.35159230
59MP0003011_delayed_dark_adaptation1.33988496
60MP0002067_abnormal_sensory_capabilities1.30984693
61MP0002733_abnormal_thermal_nociception1.29495492
62MP0001501_abnormal_sleep_pattern1.29278494
63MP0002163_abnormal_gland_morphology1.29011043
64MP0004924_abnormal_behavior1.25793193
65MP0005386_behavior/neurological_phenoty1.25793193
66MP0000631_abnormal_neuroendocrine_gland1.24532624
67MP0001486_abnormal_startle_reflex1.24277777
68MP0002272_abnormal_nervous_system1.19993376
69MP0004134_abnormal_chest_morphology1.19225421
70MP0005084_abnormal_gallbladder_morpholo1.16950252
71MP0005423_abnormal_somatic_nervous1.16935767
72MP0004147_increased_porphyrin_level1.15857119
73MP0003646_muscle_fatigue1.15765973
74MP0008058_abnormal_DNA_repair1.15695948
75MP0003252_abnormal_bile_duct1.15322948
76MP0002160_abnormal_reproductive_system1.14997669
77MP0002557_abnormal_social/conspecific_i1.14859598
78MP0001905_abnormal_dopamine_level1.08834171
79MP0001764_abnormal_homeostasis1.08125241
80MP0000049_abnormal_middle_ear1.07694090
81MP0003950_abnormal_plasma_membrane1.07068352
82MP0008789_abnormal_olfactory_epithelium1.06863533
83MP0002928_abnormal_bile_duct1.06669102
84MP0008775_abnormal_heart_ventricle1.03480546
85MP0004145_abnormal_muscle_electrophysio1.01899898
86MP0004142_abnormal_muscle_tone1.01796251
87MP0005389_reproductive_system_phenotype0.99583266
88MP0000681_abnormal_thyroid_gland0.97645684
89MP0008995_early_reproductive_senescence0.97127081
90MP0004782_abnormal_surfactant_physiolog0.96455678
91MP0005503_abnormal_tendon_morphology0.96053703
92MP0002229_neurodegeneration0.93828639
93MP0003718_maternal_effect0.93617489
94MP0002277_abnormal_respiratory_mucosa0.89655574
95MP0005394_taste/olfaction_phenotype0.88051283
96MP0005499_abnormal_olfactory_system0.88051283
97MP0002127_abnormal_cardiovascular_syste0.87934785
98MP0000230_abnormal_systemic_arterial0.87164047
99MP0005195_abnormal_posterior_eye0.87109846
100MP0002095_abnormal_skin_pigmentation0.86503518
101MP0002909_abnormal_adrenal_gland0.84602888
102MP0008961_abnormal_basal_metabolism0.84462351
103MP0000538_abnormal_urinary_bladder0.84451067
104MP0003698_abnormal_male_reproductive0.82872463
105MP0002177_abnormal_outer_ear0.82613376
106MP0002752_abnormal_somatic_nervous0.82059472
107MP0005410_abnormal_fertilization0.81825808
108MP0005167_abnormal_blood-brain_barrier0.81645222
109MP0002693_abnormal_pancreas_physiology0.81477475
110MP0005083_abnormal_biliary_tract0.81159319
111MP0003755_abnormal_palate_morphology0.81042408
112MP0005379_endocrine/exocrine_gland_phen0.80963951
113MP0005377_hearing/vestibular/ear_phenot0.80933159
114MP0003878_abnormal_ear_physiology0.80933159
115MP0004215_abnormal_myocardial_fiber0.80070636
116MP0000026_abnormal_inner_ear0.79544070
117MP0001440_abnormal_grooming_behavior0.79191125
118MP0009250_abnormal_appendicular_skeleto0.78893322
119MP0001929_abnormal_gametogenesis0.78412480
120MP0001963_abnormal_hearing_physiology0.76955233
121MP0001502_abnormal_circadian_rhythm0.75543989
122MP0002210_abnormal_sex_determination0.74704607
123MP0004811_abnormal_neuron_physiology0.73407737
124MP0003879_abnormal_hair_cell0.73110591
125MP0000566_synostosis0.72877191
126MP0000516_abnormal_urinary_system0.70723403
127MP0005367_renal/urinary_system_phenotyp0.70723403
128MP0003656_abnormal_erythrocyte_physiolo0.69967601
129MP0003122_maternal_imprinting0.66807670
130MP0003123_paternal_imprinting0.66081383
131MP0004742_abnormal_vestibular_system0.64655114
132MP0002148_abnormal_hypersensitivity_rea0.64420692
133MP0000955_abnormal_spinal_cord0.64373362
134MP0003136_yellow_coat_color0.64192248
135MP0005409_darkened_coat_color0.63949648
136MP0003137_abnormal_impulse_conducting0.63601055
137MP0008877_abnormal_DNA_methylation0.62303452
138MP0001324_abnormal_eye_pigmentation0.61645457
139MP0004381_abnormal_hair_follicle0.60888931
140MP0001270_distended_abdomen0.59632085
141MP0001186_pigmentation_phenotype0.59579726
142MP0002066_abnormal_motor_capabilities/c0.57315256
143MP0000678_abnormal_parathyroid_gland0.57014759
144MP0001485_abnormal_pinna_reflex0.56805651

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)5.73680361
2Hypothermia (HP:0002045)4.77140195
3Abnormal hair whorl (HP:0010721)4.67331180
4Focal motor seizures (HP:0011153)4.47034125
5Fair hair (HP:0002286)4.42297221
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.40453090
7Hypoplasia of the fovea (HP:0007750)4.40453090
8Pancreatic cysts (HP:0001737)4.20929280
9Congenital stationary night blindness (HP:0007642)3.97892661
10Molar tooth sign on MRI (HP:0002419)3.84327535
11Abnormality of midbrain morphology (HP:0002418)3.84327535
12Generalized hypopigmentation of hair (HP:0011358)3.77371557
13Progressive cerebellar ataxia (HP:0002073)3.64669765
14Hyperventilation (HP:0002883)3.61012422
15Abnormality of the renal cortex (HP:0011035)3.57308440
16Abnormal rod and cone electroretinograms (HP:0008323)3.51336531
17Abnormality of the fovea (HP:0000493)3.43429934
18Attenuation of retinal blood vessels (HP:0007843)3.42905187
19Nephronophthisis (HP:0000090)3.42531644
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26057516
21Optic neuritis (HP:0100653)3.23421949
22Retrobulbar optic neuritis (HP:0100654)3.23421949
23Abnormality of the renal medulla (HP:0100957)3.20905320
24Epileptic encephalopathy (HP:0200134)3.16404051
25Abolished electroretinogram (ERG) (HP:0000550)3.16265064
26Prostate neoplasm (HP:0100787)3.13208491
27Abnormality of incisor morphology (HP:0011063)3.00880476
28Blue irides (HP:0000635)2.97176382
29Optic nerve hypoplasia (HP:0000609)2.90354894
30Protruding tongue (HP:0010808)2.90311676
31Aplasia/Hypoplasia of the macula (HP:0008059)2.89586085
32Pendular nystagmus (HP:0012043)2.88994528
33Type II lissencephaly (HP:0007260)2.84887605
34Pancreatic fibrosis (HP:0100732)2.82671717
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80734120
36Arthropathy (HP:0003040)2.76184611
37Tubular atrophy (HP:0000092)2.75859601
38Fetal akinesia sequence (HP:0001989)2.75304507
39Abnormality of macular pigmentation (HP:0008002)2.72855643
40Chromsome breakage (HP:0040012)2.72714716
41Keratoconus (HP:0000563)2.71103356
42Increased corneal curvature (HP:0100692)2.71103356
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.69047352
44True hermaphroditism (HP:0010459)2.68078393
45Neonatal hypoglycemia (HP:0001998)2.68056801
46Polydipsia (HP:0001959)2.64984708
47Abnormal drinking behavior (HP:0030082)2.64984708
48Albinism (HP:0001022)2.61413482
49Congenital sensorineural hearing impairment (HP:0008527)2.57310193
50Tented upper lip vermilion (HP:0010804)2.55541859
51Atonic seizures (HP:0010819)2.55492527
52Alveolar cell carcinoma (HP:0006519)2.53193270
53Severe visual impairment (HP:0001141)2.51244418
54Chronic hepatic failure (HP:0100626)2.49827004
55Gaze-evoked nystagmus (HP:0000640)2.49515773
56Cystic liver disease (HP:0006706)2.45351198
57Polyuria (HP:0000103)2.44355025
58Short tibia (HP:0005736)2.43300794
59Large for gestational age (HP:0001520)2.41219053
60Nephrogenic diabetes insipidus (HP:0009806)2.38118911
61Medial flaring of the eyebrow (HP:0010747)2.37924336
62Genetic anticipation (HP:0003743)2.32591684
63Keratitis (HP:0000491)2.32018561
64Decreased central vision (HP:0007663)2.29282581
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28357789
66Type 2 muscle fiber atrophy (HP:0003554)2.27817877
67Abnormality of alanine metabolism (HP:0010916)2.26378908
68Hyperalaninemia (HP:0003348)2.26378908
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26378908
70Metaphyseal dysplasia (HP:0100255)2.25494360
71Thyroid carcinoma (HP:0002890)2.25025688
72Orchitis (HP:0100796)2.24410095
73Volvulus (HP:0002580)2.22224752
74Hip dysplasia (HP:0001385)2.21079594
75Aplasia/Hypoplasia affecting the retina (HP:0008061)2.20663153
76Inability to walk (HP:0002540)2.20299847
77Absent speech (HP:0001344)2.18959261
78Cerebellar dysplasia (HP:0007033)2.18498526
79Intestinal atresia (HP:0011100)2.18066694
80Polyphagia (HP:0002591)2.16325420
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14144718
82Gait imbalance (HP:0002141)2.12921300
83Thyroid-stimulating hormone excess (HP:0002925)2.12734262
84Bony spicule pigmentary retinopathy (HP:0007737)2.12657398
85Congenital primary aphakia (HP:0007707)2.12275314
86Sclerocornea (HP:0000647)2.11724071
87Irregular epiphyses (HP:0010582)2.10661104
88Anencephaly (HP:0002323)2.10219902
89Neoplasm of the tracheobronchial system (HP:0100552)2.08961757
90Astigmatism (HP:0000483)2.06470720
91Congenital hepatic fibrosis (HP:0002612)2.05925816
92Spinal muscular atrophy (HP:0007269)2.04386713
93Abnormality of the intervertebral disk (HP:0005108)2.02938076
94Esotropia (HP:0000565)2.02766828
95Hemiparesis (HP:0001269)2.02755660
96Generalized hypopigmentation (HP:0007513)2.01213340
97Lissencephaly (HP:0001339)2.01095613
98Abnormality of the right ventricle (HP:0001707)2.00214709
99Progressive inability to walk (HP:0002505)1.99696232
100Small hand (HP:0200055)1.99362842
101Furrowed tongue (HP:0000221)1.99203365
102Ketoacidosis (HP:0001993)1.99125118
103Supernumerary spleens (HP:0009799)1.98400753
104Aplasia/Hypoplasia of the lens (HP:0008063)1.98223794
105Disproportionate short-trunk short stature (HP:0003521)1.98140341
106Broad-based gait (HP:0002136)1.97178278
107Poor suck (HP:0002033)1.97037568
108Methylmalonic acidemia (HP:0002912)1.96346690
109Optic nerve coloboma (HP:0000588)1.96179302
110Vaginal atresia (HP:0000148)1.95859599
111Chorioretinal atrophy (HP:0000533)1.95668933
112Patent foramen ovale (HP:0001655)1.95566877
113Hypomagnesemia (HP:0002917)1.94476269
114Spinal canal stenosis (HP:0003416)1.93905441
115Optic disc pallor (HP:0000543)1.92637014
116Abnormal urine output (HP:0012590)1.92327534
117Methylmalonic aciduria (HP:0012120)1.90194360
118Retinitis pigmentosa (HP:0000510)1.90153868
119Septo-optic dysplasia (HP:0100842)1.90046951
120Tubulointerstitial abnormality (HP:0001969)1.89824085
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.89593914
122Type I transferrin isoform profile (HP:0003642)1.89292512
123Abnormality of the labia minora (HP:0012880)1.87396263
124Tubulointerstitial nephritis (HP:0001970)1.86629452
125Constricted visual fields (HP:0001133)1.85001431
126Male pseudohermaphroditism (HP:0000037)1.84783289
127Renal cortical cysts (HP:0000803)1.84032094
128Corneal dystrophy (HP:0001131)1.83103819
129Bulbar palsy (HP:0001283)1.83018881
130Thyroiditis (HP:0100646)1.82605866
131Submucous cleft hard palate (HP:0000176)1.82129182
132Genital tract atresia (HP:0001827)1.82054018
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.81889183
134Absent/shortened dynein arms (HP:0200106)1.81889183
135Bradycardia (HP:0001662)1.81885961
136Limb dystonia (HP:0002451)1.81678475
137Horizontal nystagmus (HP:0000666)1.81400518
138Neoplasm of the adrenal cortex (HP:0100641)1.79862610
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.79564554
140Aplasia cutis congenita (HP:0001057)1.79492602
141Poor coordination (HP:0002370)1.78129694
142Decreased circulating renin level (HP:0003351)1.77847698
143Hypokalemic alkalosis (HP:0001949)1.77270943
144Keratoconjunctivitis sicca (HP:0001097)1.76328031
145Xerostomia (HP:0000217)1.75670281
146Pachygyria (HP:0001302)1.74968861
147Postaxial hand polydactyly (HP:0001162)1.73711409
148Recurrent corneal erosions (HP:0000495)1.71800634
149Autoamputation (HP:0001218)1.71142404
150Insulin-resistant diabetes mellitus (HP:0000831)1.70696658
151Occipital encephalocele (HP:0002085)1.69196787
152Papillary thyroid carcinoma (HP:0002895)1.68355502
153Myelomeningocele (HP:0002475)1.68119677
154Increased IgM level (HP:0003496)1.67667409
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67010706
156White forelock (HP:0002211)1.65346929
157Focal seizures (HP:0007359)1.65020594
158Myositis (HP:0100614)1.64523250
159Abnormality of the incisor (HP:0000676)1.62897178
160Muscle fiber atrophy (HP:0100295)1.62838581
161Postaxial foot polydactyly (HP:0001830)1.60905704
162Gastroesophageal reflux (HP:0002020)1.60169889
163Palpebral edema (HP:0100540)1.59473680
164Bell-shaped thorax (HP:0001591)1.59361817
165Iris hypopigmentation (HP:0007730)1.59279958
166Keratoconjunctivitis (HP:0001096)1.59106984
167Patchy hypopigmentation of hair (HP:0011365)1.57774905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.91007959
2FRK5.80838462
3SIK33.81486726
4MAP2K73.54537048
5MAP4K22.94075881
6AKT32.64437819
7STK242.51854249
8WNK32.50422767
9YES12.41794501
10MAP3K42.38394801
11VRK12.37923951
12EPHA42.36821345
13TRIM282.36454739
14GRK12.30526828
15ZAK2.27244887
16NTRK32.26546683
17NUAK12.17813652
18PRPF4B2.15168713
19BMPR1B2.15154348
20PLK22.07822708
21WNK41.97248199
22STK38L1.97132279
23SGK21.97093720
24OXSR11.90295272
25MAP3K141.76470466
26MKNK21.75867507
27GRK71.75057560
28STK391.73882324
29TNIK1.67257390
30ADRBK21.65566741
31TXK1.56305595
32PAK31.48658276
33BMPR21.43655339
34ERBB31.35373688
35ACVR1B1.35137751
36MAPK131.33894539
37IRAK31.27724235
38SGK31.27376750
39PLK41.25686086
40MUSK1.24137649
41SGK4941.20818617
42SGK2231.20818617
43NEK61.17696660
44CDK191.14859580
45MAP3K121.14351851
46BCKDK1.13078179
47PRKCE1.12231852
48TLK11.10628848
49TAOK31.09163702
50PRKCG1.06826266
51PLK31.03615824
52MKNK11.02611352
53BLK0.99801920
54PINK10.96102824
55MATK0.95083039
56ERBB40.94095688
57RPS6KB10.93585844
58CSNK1G20.89274475
59CSNK1G10.88933144
60MINK10.88111232
61MAP3K60.87275944
62CSNK1G30.86608187
63EIF2AK30.84116306
64IRAK40.83448289
65PTK2B0.82654856
66STK160.82027996
67PRKCH0.80872562
68NTRK20.79701466
69MST40.78446280
70GRK50.78024771
71PNCK0.77839595
72CSNK1A1L0.75539570
73PAK60.74568234
74FGFR20.72692595
75EPHA30.72557562
76NEK20.72514801
77MAP2K40.72176899
78STK30.70567892
79TRPM70.70324298
80CDK80.69715826
81CDK30.69297050
82EIF2AK20.67978215
83CAMK10.67695032
84PHKG10.66370562
85PHKG20.66370562
86IRAK10.66283083
87NTRK10.66271854
88DYRK20.64639220
89RPS6KA20.64226921
90BRSK20.62655794
91DAPK10.62548881
92MARK10.62532481
93PIK3CA0.62118647
94ADRBK10.61964063
95IKBKB0.61475165
96FER0.59060290
97TIE10.58809547
98RPS6KA40.58803844
99NLK0.58179034
100FLT30.57970557
101BCR0.57758681
102SIK20.57363266
103CAMK2A0.57257736
104CAMKK20.57214046
105PRKAA20.57073597
106INSRR0.53110110
107TSSK60.52984138
108TEC0.52883157
109TNK20.50493833
110MAP3K70.47713038
111PRKCI0.47544723
112CCNB10.46226300
113PRKAA10.44899988
114DAPK20.44496967
115PKN10.43190565
116TGFBR10.43034442
117CSNK1D0.42446808
118MAPK70.42061826
119KIT0.40757372
120RIPK40.39728930
121MARK30.39602898
122CHUK0.39546840
123STK110.38278956
124MAPKAPK50.38037523
125CAMK2G0.38001134
126DYRK1A0.37771378
127PRKCD0.37596284
128MAP2K10.36597266
129LYN0.36436204
130SGK10.36386787
131RPS6KA50.36047400
132MAP2K60.35351823
133PRKG10.34764699
134RPS6KL10.34691574
135RPS6KC10.34691574
136PRKACA0.34414700
137MAPK80.34254008
138LIMK10.33980962
139PRKCA0.33651712
140RPS6KA60.31963893
141PRKCQ0.31833121
142CAMK2B0.31216405
143IGF1R0.31148404
144SRPK10.29413745
145HIPK20.26125659
146MAPK30.24933993
147SYK0.24289034
148CDK50.23366873
149WNK10.23273933
150CSNK1A10.22585024
151MYLK0.22409665
152PRKACB0.21878557

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60779885
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.99482010
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72784573
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.69552900
5Synaptic vesicle cycle_Homo sapiens_hsa047212.68438175
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.65397337
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60620298
8Collecting duct acid secretion_Homo sapiens_hsa049662.57054999
9Butanoate metabolism_Homo sapiens_hsa006502.55712164
10Olfactory transduction_Homo sapiens_hsa047402.42744099
11Linoleic acid metabolism_Homo sapiens_hsa005912.26929478
12Selenocompound metabolism_Homo sapiens_hsa004502.25729329
13SNARE interactions in vesicular transport_Homo sapiens_hsa041302.19697743
14Morphine addiction_Homo sapiens_hsa050322.18579682
15Nitrogen metabolism_Homo sapiens_hsa009102.16496771
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15818451
17* Serotonergic synapse_Homo sapiens_hsa047261.97820639
18Circadian entrainment_Homo sapiens_hsa047131.94791550
19Rheumatoid arthritis_Homo sapiens_hsa053231.94131884
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.88057532
21GABAergic synapse_Homo sapiens_hsa047271.81572018
22Tryptophan metabolism_Homo sapiens_hsa003801.80196413
23Type I diabetes mellitus_Homo sapiens_hsa049401.77970749
24Phagosome_Homo sapiens_hsa041451.72591146
25* Taste transduction_Homo sapiens_hsa047421.61867850
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60745190
27Glutamatergic synapse_Homo sapiens_hsa047241.59810856
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57702271
29RNA polymerase_Homo sapiens_hsa030201.49052555
30Vibrio cholerae infection_Homo sapiens_hsa051101.48945596
31Propanoate metabolism_Homo sapiens_hsa006401.44571872
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44448325
33Caffeine metabolism_Homo sapiens_hsa002321.42799991
34Autoimmune thyroid disease_Homo sapiens_hsa053201.41658625
35Dopaminergic synapse_Homo sapiens_hsa047281.41268199
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.37827500
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37729225
38Regulation of autophagy_Homo sapiens_hsa041401.36853044
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.36814994
40Allograft rejection_Homo sapiens_hsa053301.35567598
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34418788
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33185747
43Amphetamine addiction_Homo sapiens_hsa050311.29786842
44Cholinergic synapse_Homo sapiens_hsa047251.28933764
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28433802
46ABC transporters_Homo sapiens_hsa020101.28234976
47Homologous recombination_Homo sapiens_hsa034401.27406052
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23466303
49Calcium signaling pathway_Homo sapiens_hsa040201.21811956
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20042434
51Other glycan degradation_Homo sapiens_hsa005111.19729609
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17292525
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16761885
54Peroxisome_Homo sapiens_hsa041461.16214370
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11562526
56Sphingolipid metabolism_Homo sapiens_hsa006001.10262947
57Oxidative phosphorylation_Homo sapiens_hsa001901.10229635
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08130158
59Insulin secretion_Homo sapiens_hsa049111.04152850
60Chemical carcinogenesis_Homo sapiens_hsa052041.03910255
61Cocaine addiction_Homo sapiens_hsa050301.02047086
62Glycerolipid metabolism_Homo sapiens_hsa005611.01377228
63Phototransduction_Homo sapiens_hsa047441.00436675
64RNA degradation_Homo sapiens_hsa030180.99215144
65Long-term depression_Homo sapiens_hsa047300.98999313
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97989143
67Base excision repair_Homo sapiens_hsa034100.95349282
68Retinol metabolism_Homo sapiens_hsa008300.92935915
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92919963
70Cardiac muscle contraction_Homo sapiens_hsa042600.91259589
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.90414910
72Graft-versus-host disease_Homo sapiens_hsa053320.89815675
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87531806
74Fat digestion and absorption_Homo sapiens_hsa049750.86304711
75African trypanosomiasis_Homo sapiens_hsa051430.83509790
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82813891
77Primary immunodeficiency_Homo sapiens_hsa053400.82511930
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82449965
79Proteasome_Homo sapiens_hsa030500.82023772
80Circadian rhythm_Homo sapiens_hsa047100.81407824
81Fanconi anemia pathway_Homo sapiens_hsa034600.80657042
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78335899
83Histidine metabolism_Homo sapiens_hsa003400.78243070
84Dorso-ventral axis formation_Homo sapiens_hsa043200.77819002
85Tuberculosis_Homo sapiens_hsa051520.76980775
86Mineral absorption_Homo sapiens_hsa049780.76508137
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73357353
88Legionellosis_Homo sapiens_hsa051340.71489942
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71401393
90Axon guidance_Homo sapiens_hsa043600.71130235
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71045487
92Arachidonic acid metabolism_Homo sapiens_hsa005900.68902401
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.68122853
94beta-Alanine metabolism_Homo sapiens_hsa004100.67897714
95Non-homologous end-joining_Homo sapiens_hsa034500.66176567
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65777229
97Purine metabolism_Homo sapiens_hsa002300.65197002
98Salivary secretion_Homo sapiens_hsa049700.64672982
99Metabolic pathways_Homo sapiens_hsa011000.64663268
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63908434
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62921177
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62404222
103cAMP signaling pathway_Homo sapiens_hsa040240.62201608
104Measles_Homo sapiens_hsa051620.61626383
105Renin secretion_Homo sapiens_hsa049240.61068215
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.59732056
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59403321
108Ovarian steroidogenesis_Homo sapiens_hsa049130.58009844
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56667212
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.56644322
111Phenylalanine metabolism_Homo sapiens_hsa003600.56519627
112Huntingtons disease_Homo sapiens_hsa050160.54971664
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54128462
114Melanoma_Homo sapiens_hsa052180.53449558
115Alzheimers disease_Homo sapiens_hsa050100.52526553
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51412816
117Hematopoietic cell lineage_Homo sapiens_hsa046400.50651797
118ErbB signaling pathway_Homo sapiens_hsa040120.50407438
119TNF signaling pathway_Homo sapiens_hsa046680.50254355
120Long-term potentiation_Homo sapiens_hsa047200.50201292
121Basal transcription factors_Homo sapiens_hsa030220.48276098
122Inositol phosphate metabolism_Homo sapiens_hsa005620.47325255
123Sulfur metabolism_Homo sapiens_hsa009200.47146755
124Ether lipid metabolism_Homo sapiens_hsa005650.46855622
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46330598
126Asthma_Homo sapiens_hsa053100.45574237
127One carbon pool by folate_Homo sapiens_hsa006700.43849199
128Hedgehog signaling pathway_Homo sapiens_hsa043400.43320509
129Ras signaling pathway_Homo sapiens_hsa040140.43226424
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43160269
131Parkinsons disease_Homo sapiens_hsa050120.41666437
132Protein export_Homo sapiens_hsa030600.41583208
133Fatty acid degradation_Homo sapiens_hsa000710.40430437
134Arginine and proline metabolism_Homo sapiens_hsa003300.39765643
135Chemokine signaling pathway_Homo sapiens_hsa040620.39707925
136Wnt signaling pathway_Homo sapiens_hsa043100.39275383
137Steroid biosynthesis_Homo sapiens_hsa001000.39020811
138Tyrosine metabolism_Homo sapiens_hsa003500.38785964
139Mismatch repair_Homo sapiens_hsa034300.38171246
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38031846
141Influenza A_Homo sapiens_hsa051640.38011889
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.37546185
143Pancreatic secretion_Homo sapiens_hsa049720.37175797
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36477375
145MAPK signaling pathway_Homo sapiens_hsa040100.35780777
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.35546900
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35510184
148Pertussis_Homo sapiens_hsa051330.34180159
149Malaria_Homo sapiens_hsa051440.34012342
150Salmonella infection_Homo sapiens_hsa051320.32927649
151Folate biosynthesis_Homo sapiens_hsa007900.32510318
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31397339

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