HSPE1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.07931493
2chaperone-mediated protein transport (GO:0072321)6.22419096
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.05644489
4ATP synthesis coupled proton transport (GO:0015986)6.05644489
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.99458897
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.54317136
7ribosomal small subunit assembly (GO:0000028)5.13131666
8DNA deamination (GO:0045006)5.12470384
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.93691766
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.93691766
11NADH dehydrogenase complex assembly (GO:0010257)4.93691766
12GTP biosynthetic process (GO:0006183)4.91495756
13protein complex biogenesis (GO:0070271)4.77598313
14mitochondrial respiratory chain complex assembly (GO:0033108)4.59845900
15UTP biosynthetic process (GO:0006228)4.34050832
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.11394765
17respiratory electron transport chain (GO:0022904)4.01916604
18chromatin remodeling at centromere (GO:0031055)3.99942845
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97258550
20UTP metabolic process (GO:0046051)3.96385854
21electron transport chain (GO:0022900)3.94923012
22rRNA modification (GO:0000154)3.90462257
23proteasome assembly (GO:0043248)3.89462978
24maturation of SSU-rRNA (GO:0030490)3.84913185
25purine nucleoside triphosphate biosynthetic process (GO:0009145)3.81362624
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80928409
27purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.79673376
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78866417
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78866417
30CENP-A containing nucleosome assembly (GO:0034080)3.75718585
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73995176
32behavioral response to nicotine (GO:0035095)3.63764439
33rRNA methylation (GO:0031167)3.56468033
34hydrogen ion transmembrane transport (GO:1902600)3.52937556
35CTP biosynthetic process (GO:0006241)3.52372834
36CTP metabolic process (GO:0046036)3.52372834
37positive regulation of protein homodimerization activity (GO:0090073)3.50287934
38ATP biosynthetic process (GO:0006754)3.44361045
39water-soluble vitamin biosynthetic process (GO:0042364)3.41097685
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.38305320
41termination of RNA polymerase III transcription (GO:0006386)3.38305320
42cellular component biogenesis (GO:0044085)3.36777112
43ribonucleoside triphosphate biosynthetic process (GO:0009201)3.36085172
44rRNA processing (GO:0006364)3.23089863
45pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.18613885
46replication fork processing (GO:0031297)3.16958387
47ribosome biogenesis (GO:0042254)3.16372798
48rRNA metabolic process (GO:0016072)3.15812400
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14227989
50pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14002977
51regulation of immunoglobulin secretion (GO:0051023)3.12263618
52cullin deneddylation (GO:0010388)3.10209914
53viral transcription (GO:0019083)3.10144358
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.08009909
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.08009909
56isotype switching (GO:0045190)3.08009909
57respiratory chain complex IV assembly (GO:0008535)3.07425152
58proton transport (GO:0015992)3.06349225
59translational termination (GO:0006415)3.04729224
60regulation of cellular amino acid metabolic process (GO:0006521)3.04340004
61ribonucleoprotein complex biogenesis (GO:0022613)3.03928851
62ribosomal large subunit biogenesis (GO:0042273)3.03789992
63translation (GO:0006412)3.02756608
64histone exchange (GO:0043486)3.02639340
65guanosine-containing compound biosynthetic process (GO:1901070)3.01017963
66hydrogen transport (GO:0006818)2.98623938
67regulation of chronic inflammatory response (GO:0002676)2.98230790
68protein deneddylation (GO:0000338)2.97470461
69pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.96936372
70protein-cofactor linkage (GO:0018065)2.94642590
71DNA replication-independent nucleosome assembly (GO:0006336)2.89216046
72DNA replication-independent nucleosome organization (GO:0034724)2.89216046
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87616450
74nucleoside triphosphate biosynthetic process (GO:0009142)2.86941713
75head development (GO:0060322)2.86478644
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.86349555
77ribosomal small subunit biogenesis (GO:0042274)2.84518219
78negative regulation of ligase activity (GO:0051352)2.83578812
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83578812
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82006644
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82006644
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82006644
83DNA strand renaturation (GO:0000733)2.81848929
84intracellular protein transmembrane import (GO:0044743)2.81242110
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80957182
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79603757
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79603757
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79243604
89cotranslational protein targeting to membrane (GO:0006613)2.79076435
90cytochrome complex assembly (GO:0017004)2.77362445
91cellular ketone body metabolic process (GO:0046950)2.76680242
92protein targeting to ER (GO:0045047)2.76579144
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76153572
94regulation of oxidative phosphorylation (GO:0002082)2.75141788
95nucleoside diphosphate phosphorylation (GO:0006165)2.74664122
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.74593334
97kinetochore assembly (GO:0051382)2.74310584
98piRNA metabolic process (GO:0034587)2.73631653
99tRNA metabolic process (GO:0006399)2.73033043
100tRNA processing (GO:0008033)2.71989283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.36746143
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.59296083
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.99095883
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36403090
5EZH2_22144423_ChIP-Seq_EOC_Human3.32739458
6VDR_22108803_ChIP-Seq_LS180_Human3.07631873
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97699563
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.86907244
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.86685635
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.82639807
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80438881
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74443052
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56046638
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45235149
15ELK1_19687146_ChIP-ChIP_HELA_Human2.29876775
16VDR_23849224_ChIP-Seq_CD4+_Human2.24921631
17ZNF274_21170338_ChIP-Seq_K562_Hela2.09042624
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02634978
19EWS_26573619_Chip-Seq_HEK293_Human1.99336612
20MYC_18940864_ChIP-ChIP_HL60_Human1.82939596
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79907497
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.79466686
23YY1_21170310_ChIP-Seq_MESCs_Mouse1.75981713
24FOXP3_21729870_ChIP-Seq_TREG_Human1.74949520
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68362836
26TTF2_22483619_ChIP-Seq_HELA_Human1.67331641
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65257097
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64398581
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62444729
30TP53_22573176_ChIP-Seq_HFKS_Human1.60300456
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60068538
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58752548
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.58488712
34GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56394715
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55317644
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52924689
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47681304
38GABP_19822575_ChIP-Seq_HepG2_Human1.43447251
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40971956
40IRF1_19129219_ChIP-ChIP_H3396_Human1.40146331
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37560953
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37477981
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35340149
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35238401
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34724790
46XRN2_22483619_ChIP-Seq_HELA_Human1.30527166
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29978955
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29012031
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26679529
50DCP1A_22483619_ChIP-Seq_HELA_Human1.20321700
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19753918
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16932955
53P300_19829295_ChIP-Seq_ESCs_Human1.15502357
54FUS_26573619_Chip-Seq_HEK293_Human1.14090502
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14048196
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.14048196
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14011384
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13990024
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.13933414
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12593052
61IGF1R_20145208_ChIP-Seq_DFB_Human1.12051900
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12048529
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.12014565
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09394938
65REST_21632747_ChIP-Seq_MESCs_Mouse1.04065853
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02757838
67SOX2_19829295_ChIP-Seq_ESCs_Human1.01022603
68NANOG_19829295_ChIP-Seq_ESCs_Human1.01022603
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00815118
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00692797
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00606425
72ER_23166858_ChIP-Seq_MCF-7_Human0.98519521
73NCOR_22424771_ChIP-Seq_293T_Human0.98232588
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98154898
75GBX2_23144817_ChIP-Seq_PC3_Human0.97348998
76E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94993280
77REST_18959480_ChIP-ChIP_MESCs_Mouse0.94814230
78BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93985421
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93521175
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93419699
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93109565
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92399455
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91437434
84TCF4_22108803_ChIP-Seq_LS180_Human0.91199553
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90091407
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88122804
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.87745787
88CBX2_27304074_Chip-Seq_ESCs_Mouse0.87625764
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.86252603
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.85642068
91P53_22387025_ChIP-Seq_ESCs_Mouse0.85422505
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85055294
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83952420
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81239558
95HOXB7_26014856_ChIP-Seq_BT474_Human0.81229973
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81192196
97E2F7_22180533_ChIP-Seq_HELA_Human0.80075814
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.79809291
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.78659874
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78612214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.31243662
2MP0008877_abnormal_DNA_methylation3.76486483
3MP0002102_abnormal_ear_morphology2.85105545
4MP0003787_abnormal_imprinting2.73427454
5MP0004147_increased_porphyrin_level2.58094568
6MP0009379_abnormal_foot_pigmentation2.49033619
7MP0003693_abnormal_embryo_hatching2.39640531
8MP0001348_abnormal_lacrimal_gland2.26455007
9MP0003122_maternal_imprinting2.23218769
10MP0002653_abnormal_ependyma_morphology2.15342098
11MP0001873_stomach_inflammation2.01478179
12MP0003718_maternal_effect2.00250728
13MP0008872_abnormal_physiological_respon1.88595476
14MP0003121_genomic_imprinting1.81749804
15MP0005423_abnormal_somatic_nervous1.68856304
16MP0002733_abnormal_thermal_nociception1.66521849
17MP0006036_abnormal_mitochondrial_physio1.65921683
18MP0004957_abnormal_blastocyst_morpholog1.60510900
19MP0008058_abnormal_DNA_repair1.60393719
20MP0001968_abnormal_touch/_nociception1.59996475
21MP0008875_abnormal_xenobiotic_pharmacok1.59547594
22MP0002272_abnormal_nervous_system1.57660555
23MP0004142_abnormal_muscle_tone1.56474240
24MP0001485_abnormal_pinna_reflex1.55815781
25MP0004145_abnormal_muscle_electrophysio1.54203536
26MP0003786_premature_aging1.52313248
27MP0002277_abnormal_respiratory_mucosa1.52189636
28MP0001529_abnormal_vocalization1.51971726
29MP0002735_abnormal_chemical_nociception1.51576692
30MP0003123_paternal_imprinting1.49788463
31MP0003880_abnormal_central_pattern1.49570634
32MP0010094_abnormal_chromosome_stability1.49130911
33MP0004043_abnormal_pH_regulation1.47913047
34MP0009745_abnormal_behavioral_response1.46317214
35MP0001970_abnormal_pain_threshold1.44396407
36MP0002184_abnormal_innervation1.43165034
37MP0004742_abnormal_vestibular_system1.42563531
38MP0005551_abnormal_eye_electrophysiolog1.41170557
39MP0000049_abnormal_middle_ear1.39740449
40MP0005084_abnormal_gallbladder_morpholo1.37283505
41MP0003646_muscle_fatigue1.36380962
42MP0002736_abnormal_nociception_after1.35407574
43MP0006072_abnormal_retinal_apoptosis1.34562922
44MP0003635_abnormal_synaptic_transmissio1.33008925
45MP0004859_abnormal_synaptic_plasticity1.25197603
46MP0003011_delayed_dark_adaptation1.24961251
47MP0006035_abnormal_mitochondrial_morpho1.24868832
48MP0002163_abnormal_gland_morphology1.23663209
49MP0001440_abnormal_grooming_behavior1.22889103
50MP0001986_abnormal_taste_sensitivity1.21957778
51MP0003936_abnormal_reproductive_system1.21755188
52MP0008007_abnormal_cellular_replicative1.20938089
53MP0000569_abnormal_digit_pigmentation1.17290214
54MP0003283_abnormal_digestive_organ1.15197908
55MP0006276_abnormal_autonomic_nervous1.13183079
56MP0002063_abnormal_learning/memory/cond1.11645735
57MP0001919_abnormal_reproductive_system1.11230775
58MP0001984_abnormal_olfaction1.09568411
59MP0002557_abnormal_social/conspecific_i1.09548116
60MP0002138_abnormal_hepatobiliary_system1.09295228
61MP0005389_reproductive_system_phenotype1.09168140
62MP0001486_abnormal_startle_reflex1.08710751
63MP0003937_abnormal_limbs/digits/tail_de1.08662904
64MP0001293_anophthalmia1.08477940
65MP0002638_abnormal_pupillary_reflex1.06881014
66MP0008789_abnormal_olfactory_epithelium1.06244265
67MP0001727_abnormal_embryo_implantation1.05458056
68MP0002572_abnormal_emotion/affect_behav1.05398930
69MP0005645_abnormal_hypothalamus_physiol1.04872624
70MP0000955_abnormal_spinal_cord1.04306004
71MP0002160_abnormal_reproductive_system1.02243978
72MP0000778_abnormal_nervous_system1.01740054
73MP0009046_muscle_twitch0.98617732
74MP0002752_abnormal_somatic_nervous0.98167873
75MP0003195_calcinosis0.97980234
76MP0005379_endocrine/exocrine_gland_phen0.97829767
77MP0000631_abnormal_neuroendocrine_gland0.97550219
78MP0001188_hyperpigmentation0.96893933
79MP0008995_early_reproductive_senescence0.96649267
80MP0001790_abnormal_immune_system0.96520720
81MP0005387_immune_system_phenotype0.96520720
82MP0005671_abnormal_response_to0.95819064
83MP0003567_abnormal_fetal_cardiomyocyte0.94976504
84MP0004133_heterotaxia0.92426680
85MP0002006_tumorigenesis0.92323530
86MP0001905_abnormal_dopamine_level0.91723374
87MP0002064_seizures0.91252080
88MP0001881_abnormal_mammary_gland0.90559409
89MP0002210_abnormal_sex_determination0.88645703
90MP0004885_abnormal_endolymph0.88554518
91MP0000685_abnormal_immune_system0.86544194
92MP0002734_abnormal_mechanical_nocicepti0.84902343
93MP0001835_abnormal_antigen_presentation0.84365415
94MP0003890_abnormal_embryonic-extraembry0.84223306
95MP0008569_lethality_at_weaning0.83973940
96MP0003077_abnormal_cell_cycle0.83591812
97MP0000026_abnormal_inner_ear0.79739698
98MP0003186_abnormal_redox_activity0.78407188
99MP0003315_abnormal_perineum_morphology0.75644257
100MP0002751_abnormal_autonomic_nervous0.73985948

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.23722395
2Abnormal mitochondria in muscle tissue (HP:0008316)4.51131686
3Mitochondrial inheritance (HP:0001427)4.40801994
4Acute encephalopathy (HP:0006846)4.40136645
5Increased hepatocellular lipid droplets (HP:0006565)4.30668807
6Increased CSF lactate (HP:0002490)4.20051301
7Progressive macrocephaly (HP:0004481)4.19170433
8Lipid accumulation in hepatocytes (HP:0006561)4.06877088
9Renal Fanconi syndrome (HP:0001994)3.88501321
10Increased serum pyruvate (HP:0003542)3.76007809
11Reticulocytopenia (HP:0001896)3.59877370
12Abnormality of the labia minora (HP:0012880)3.57665492
13Hepatocellular necrosis (HP:0001404)3.45646140
14Cerebral edema (HP:0002181)3.26306125
15Myokymia (HP:0002411)3.26246021
16Abnormality of glycolysis (HP:0004366)3.13366937
17Optic disc pallor (HP:0000543)3.12423169
18Pancreatic cysts (HP:0001737)3.09236775
19Abnormality of midbrain morphology (HP:0002418)3.07683766
20Molar tooth sign on MRI (HP:0002419)3.07683766
21Increased serum lactate (HP:0002151)3.01407299
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00374885
23Hepatic necrosis (HP:0002605)2.86943506
24Pendular nystagmus (HP:0012043)2.78955187
25Increased intramyocellular lipid droplets (HP:0012240)2.74241527
26Exertional dyspnea (HP:0002875)2.73712804
27Colon cancer (HP:0003003)2.64167835
28Abnormality of renal resorption (HP:0011038)2.63999265
29True hermaphroditism (HP:0010459)2.63078636
30Respiratory difficulties (HP:0002880)2.61568214
31Agitation (HP:0000713)2.56820962
32Pancreatic fibrosis (HP:0100732)2.56044075
33Stomatitis (HP:0010280)2.45036483
343-Methylglutaconic aciduria (HP:0003535)2.44524719
35Abnormality of the pons (HP:0007361)2.41400331
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41051383
37Macrocytic anemia (HP:0001972)2.39759470
38Respiratory failure (HP:0002878)2.38249735
39Leukodystrophy (HP:0002415)2.37332525
40Septo-optic dysplasia (HP:0100842)2.36125247
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.35842225
42Nephronophthisis (HP:0000090)2.31803976
43Congenital stationary night blindness (HP:0007642)2.31250556
44Sclerocornea (HP:0000647)2.30917421
45Supernumerary spleens (HP:0009799)2.29837517
46Increased muscle lipid content (HP:0009058)2.27078179
47Exercise intolerance (HP:0003546)2.26784994
48Absent thumb (HP:0009777)2.25756254
49Hypoplasia of the pons (HP:0012110)2.25206455
50Lactic acidosis (HP:0003128)2.22819801
51Abnormality of cells of the erythroid lineage (HP:0012130)2.19300237
52IgG deficiency (HP:0004315)2.18985361
53Chromsome breakage (HP:0040012)2.17827381
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15135413
55Abnormality of DNA repair (HP:0003254)2.11625351
56Methylmalonic acidemia (HP:0002912)2.10720111
57Abnormality of alanine metabolism (HP:0010916)2.07960350
58Hyperalaninemia (HP:0003348)2.07960350
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07960350
60Aplastic anemia (HP:0001915)2.05133350
61Lethargy (HP:0001254)2.05044258
62Hyperphosphaturia (HP:0003109)2.02797473
63Meckel diverticulum (HP:0002245)2.02752848
64Increased IgM level (HP:0003496)2.02483249
65Cerebral hypomyelination (HP:0006808)2.01980972
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97119647
67Abnormality of the ileum (HP:0001549)1.94984987
68Congenital, generalized hypertrichosis (HP:0004540)1.94779720
69Abnormal hair whorl (HP:0010721)1.94188261
70Male pseudohermaphroditism (HP:0000037)1.94011610
71X-linked dominant inheritance (HP:0001423)1.91317204
72Methylmalonic aciduria (HP:0012120)1.91271243
73Abnormality of urine glucose concentration (HP:0011016)1.91041629
74Glycosuria (HP:0003076)1.91041629
75Genetic anticipation (HP:0003743)1.90932688
76Optic nerve hypoplasia (HP:0000609)1.89016697
77Pallor (HP:0000980)1.87109852
78Abnormality of the renal collecting system (HP:0004742)1.84989978
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84343122
80Progressive cerebellar ataxia (HP:0002073)1.84262051
81Duplicated collecting system (HP:0000081)1.83891325
82Multiple enchondromatosis (HP:0005701)1.82482817
83Impulsivity (HP:0100710)1.82220060
84Type 2 muscle fiber atrophy (HP:0003554)1.82043166
85Abnormal number of erythroid precursors (HP:0012131)1.81766777
86Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80417458
87Narrow forehead (HP:0000341)1.78807605
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77908598
89Anencephaly (HP:0002323)1.77750855
90Abnormality of the renal medulla (HP:0100957)1.76626253
91Horseshoe kidney (HP:0000085)1.74427331
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74125873
93Abnormality of serum amino acid levels (HP:0003112)1.72342323
94Medial flaring of the eyebrow (HP:0010747)1.71847628
95Rib fusion (HP:0000902)1.69784055
96Keratoconus (HP:0000563)1.69205056
97Increased corneal curvature (HP:0100692)1.69205056
98Myotonia (HP:0002486)1.69068907
99Abnormality of the phalanges of the 5th finger (HP:0004213)1.68553289
100CNS demyelination (HP:0007305)1.68388597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.05649453
2VRK23.95928654
3MST42.96828700
4EIF2AK12.88686274
5BUB12.52155196
6TAF12.51661183
7EIF2AK32.30781213
8CASK2.14714503
9PBK2.13544338
10VRK12.05945817
11PLK32.05814198
12NEK12.03238533
13NUAK11.98118359
14DYRK21.93065485
15NME11.91793414
16PLK41.87557317
17STK161.87072267
18SRPK11.82417947
19TLK11.82342372
20PLK21.74626226
21WNK41.64783896
22ZAK1.57802912
23DYRK31.57363456
24GRK11.53683230
25CDC71.51386571
26MKNK21.49578588
27PNCK1.46785619
28WNK31.46447548
29ADRBK21.44532996
30EIF2AK21.29801076
31MAP3K91.19388527
32TRIM281.12811343
33MINK11.12790997
34ALK1.09790307
35SIK21.04970417
36PDK21.00232868
37CDK80.95000194
38PLK10.93708732
39OXSR10.92701866
40CSNK1G20.92517747
41MAP3K40.91249092
42WEE10.90742907
43FRK0.85490943
44CSNK1G30.83300276
45MKNK10.82105013
46PIK3CA0.81271965
47NME20.78120833
48GRK50.77774550
49MAPK130.77541501
50CSNK1A1L0.76345452
51PRKCG0.75299804
52BMPR1B0.75075150
53TTK0.73724161
54ATR0.72986193
55CSNK1E0.72754305
56AURKB0.69933520
57TAOK30.68147749
58PHKG10.67855437
59PHKG20.67855437
60ADRBK10.67814766
61INSRR0.67699245
62CSNK2A20.66602585
63BCR0.66063412
64CSNK1G10.65629931
65TNIK0.62952183
66TXK0.61349925
67MARK10.61096125
68STK390.60696105
69MAP4K20.60574804
70PASK0.59161462
71MAPKAPK50.57968748
72AKT30.56100548
73NTRK20.54888863
74CSNK2A10.52993606
75EPHB20.52142107
76GRK70.51937203
77DAPK30.51589568
78SIK30.50713753
79EPHA40.50039997
80STK40.45415716
81ERBB30.44274946
82TYRO30.43283712
83PINK10.42595285
84TIE10.42299693
85PRKACA0.40292324
86ATM0.40221967
87AURKA0.38428620
88NTRK30.37231139
89CAMK2A0.36348041
90CCNB10.35246793
91PRKCI0.34706870
92CSNK1A10.34353103
93DAPK10.33542879
94CHEK10.32971101
95DYRK1A0.32709020
96CHEK20.31896861
97ILK0.30917346
98PRKDC0.29348179
99CDK140.29160322
100KIT0.29117949

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.10763570
2Oxidative phosphorylation_Homo sapiens_hsa001903.80843478
3Ribosome_Homo sapiens_hsa030103.57007820
4Parkinsons disease_Homo sapiens_hsa050123.46644676
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31565356
6RNA polymerase_Homo sapiens_hsa030202.89172508
7Protein export_Homo sapiens_hsa030602.80855849
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57959327
9Huntingtons disease_Homo sapiens_hsa050162.54000385
10Alzheimers disease_Homo sapiens_hsa050102.41406738
11Homologous recombination_Homo sapiens_hsa034402.37255238
12Vitamin B6 metabolism_Homo sapiens_hsa007502.26246387
13Cardiac muscle contraction_Homo sapiens_hsa042602.19585413
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13973664
15Mismatch repair_Homo sapiens_hsa034301.94967572
16RNA degradation_Homo sapiens_hsa030181.88479671
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84828166
18Basal transcription factors_Homo sapiens_hsa030221.84611386
19Asthma_Homo sapiens_hsa053101.84603404
20One carbon pool by folate_Homo sapiens_hsa006701.73517414
21RNA transport_Homo sapiens_hsa030131.63257002
22Propanoate metabolism_Homo sapiens_hsa006401.57220002
23Nucleotide excision repair_Homo sapiens_hsa034201.56730050
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51629913
25DNA replication_Homo sapiens_hsa030301.50739745
26Spliceosome_Homo sapiens_hsa030401.43331322
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41619352
28Pyrimidine metabolism_Homo sapiens_hsa002401.35886638
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.32721780
30Fanconi anemia pathway_Homo sapiens_hsa034601.29496902
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26061981
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20321565
33Steroid biosynthesis_Homo sapiens_hsa001001.19376484
34Sulfur relay system_Homo sapiens_hsa041221.10265901
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04155292
36Pyruvate metabolism_Homo sapiens_hsa006201.03318921
37Tryptophan metabolism_Homo sapiens_hsa003801.02430934
38Purine metabolism_Homo sapiens_hsa002301.01630323
39Phototransduction_Homo sapiens_hsa047440.99859596
40Nicotine addiction_Homo sapiens_hsa050330.99156773
41Peroxisome_Homo sapiens_hsa041460.96567294
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96197155
43Butanoate metabolism_Homo sapiens_hsa006500.93944797
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90571788
45Allograft rejection_Homo sapiens_hsa053300.87813851
46Autoimmune thyroid disease_Homo sapiens_hsa053200.86996338
47beta-Alanine metabolism_Homo sapiens_hsa004100.85645988
48Folate biosynthesis_Homo sapiens_hsa007900.82183092
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80635237
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78770241
51Linoleic acid metabolism_Homo sapiens_hsa005910.76862305
52Primary immunodeficiency_Homo sapiens_hsa053400.76523334
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76048868
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.70071530
55Base excision repair_Homo sapiens_hsa034100.69649204
56Olfactory transduction_Homo sapiens_hsa047400.67307125
57Caffeine metabolism_Homo sapiens_hsa002320.64788839
58Fatty acid degradation_Homo sapiens_hsa000710.63291836
59Nitrogen metabolism_Homo sapiens_hsa009100.63227272
60Metabolic pathways_Homo sapiens_hsa011000.62996762
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.62783726
62Non-homologous end-joining_Homo sapiens_hsa034500.57642728
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56491415
64Taste transduction_Homo sapiens_hsa047420.56178122
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53284296
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51460614
67Fat digestion and absorption_Homo sapiens_hsa049750.50906420
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50096797
69Arginine and proline metabolism_Homo sapiens_hsa003300.49104908
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45346406
71Retinol metabolism_Homo sapiens_hsa008300.44803026
72Chemical carcinogenesis_Homo sapiens_hsa052040.43350689
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41965950
74mRNA surveillance pathway_Homo sapiens_hsa030150.38214395
75Cell cycle_Homo sapiens_hsa041100.35588252
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.34953669
77Fatty acid metabolism_Homo sapiens_hsa012120.34636448
78p53 signaling pathway_Homo sapiens_hsa041150.32638331
79Selenocompound metabolism_Homo sapiens_hsa004500.31606332
80Epstein-Barr virus infection_Homo sapiens_hsa051690.31480461
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30611784
82Morphine addiction_Homo sapiens_hsa050320.29001550
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27909043
84Fatty acid elongation_Homo sapiens_hsa000620.26816152
85Serotonergic synapse_Homo sapiens_hsa047260.25109427
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25065236
87Glutamatergic synapse_Homo sapiens_hsa047240.24707167
88Rheumatoid arthritis_Homo sapiens_hsa053230.22588415
89Glycerolipid metabolism_Homo sapiens_hsa005610.21158150
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19454442
91GABAergic synapse_Homo sapiens_hsa047270.18185762
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17722647
93Ether lipid metabolism_Homo sapiens_hsa005650.17417163
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15927437
95Collecting duct acid secretion_Homo sapiens_hsa049660.15845122
96Starch and sucrose metabolism_Homo sapiens_hsa005000.14245212
97Insulin secretion_Homo sapiens_hsa049110.13626532
98Wnt signaling pathway_Homo sapiens_hsa043100.12414312
99Phenylalanine metabolism_Homo sapiens_hsa003600.12242721
100Glutathione metabolism_Homo sapiens_hsa004800.11940122

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