HSPD1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.54947656
2DNA deamination (GO:0045006)4.82921270
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13453145
4ATP synthesis coupled proton transport (GO:0015986)4.13453145
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00765249
6fucose catabolic process (GO:0019317)3.96840363
7L-fucose metabolic process (GO:0042354)3.96840363
8L-fucose catabolic process (GO:0042355)3.96840363
9water-soluble vitamin biosynthetic process (GO:0042364)3.85191666
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.84748112
11protein complex biogenesis (GO:0070271)3.83325354
12respiratory chain complex IV assembly (GO:0008535)3.80101456
13tryptophan catabolic process (GO:0006569)3.79388673
14indole-containing compound catabolic process (GO:0042436)3.79388673
15indolalkylamine catabolic process (GO:0046218)3.79388673
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.64936267
17NADH dehydrogenase complex assembly (GO:0010257)3.64936267
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64936267
19kynurenine metabolic process (GO:0070189)3.58054798
20mitochondrial respiratory chain complex assembly (GO:0033108)3.56171133
21negative regulation of telomere maintenance (GO:0032205)3.52979185
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46645559
23tryptophan metabolic process (GO:0006568)3.38668711
24cytochrome complex assembly (GO:0017004)3.38323063
25indolalkylamine metabolic process (GO:0006586)3.28632029
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25616988
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22321820
28sulfation (GO:0051923)3.20664484
29positive regulation of defense response to virus by host (GO:0002230)3.10121671
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09116444
31protein-cofactor linkage (GO:0018065)3.07649200
32electron transport chain (GO:0022900)3.05061143
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01964974
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01964974
35preassembly of GPI anchor in ER membrane (GO:0016254)3.00482180
36response to pheromone (GO:0019236)3.00301958
37respiratory electron transport chain (GO:0022904)2.96191039
38maturation of 5.8S rRNA (GO:0000460)2.93548415
39cellular ketone body metabolic process (GO:0046950)2.92646367
40protein neddylation (GO:0045116)2.90705314
41pseudouridine synthesis (GO:0001522)2.90401000
42negative regulation of mast cell activation (GO:0033004)2.88237825
43positive regulation of fatty acid transport (GO:2000193)2.87778880
44platelet dense granule organization (GO:0060155)2.86653063
45positive regulation of prostaglandin secretion (GO:0032308)2.84536518
46neuronal action potential (GO:0019228)2.84119957
47detection of light stimulus involved in visual perception (GO:0050908)2.83144889
48detection of light stimulus involved in sensory perception (GO:0050962)2.83144889
49piRNA metabolic process (GO:0034587)2.77890415
50regulation of action potential (GO:0098900)2.76011622
51phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74110019
52regulation of mesoderm development (GO:2000380)2.71916421
53nephron tubule morphogenesis (GO:0072078)2.71849155
54nephron epithelium morphogenesis (GO:0072088)2.71849155
55regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70936105
56cytidine deamination (GO:0009972)2.70410327
57cytidine metabolic process (GO:0046087)2.70410327
58cytidine catabolic process (GO:0006216)2.70410327
59transcription elongation from RNA polymerase III promoter (GO:0006385)2.68543737
60termination of RNA polymerase III transcription (GO:0006386)2.68543737
61rhodopsin mediated signaling pathway (GO:0016056)2.67333915
62negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66886138
63synaptic transmission, cholinergic (GO:0007271)2.66580064
64regulation of nuclear cell cycle DNA replication (GO:0033262)2.66540697
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66333724
66intracellular protein transmembrane import (GO:0044743)2.64955325
67protein polyglutamylation (GO:0018095)2.63358136
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61384157
69epithelial cilium movement (GO:0003351)2.60909461
70ketone body metabolic process (GO:1902224)2.60343047
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59960537
72proton transport (GO:0015992)2.59510048
73mannosylation (GO:0097502)2.59120963
74kidney morphogenesis (GO:0060993)2.58472231
75somite development (GO:0061053)2.56400926
76hydrogen ion transmembrane transport (GO:1902600)2.55816519
77axoneme assembly (GO:0035082)2.54404287
78indole-containing compound metabolic process (GO:0042430)2.54381898
79hydrogen transport (GO:0006818)2.52931636
80regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.48235739
81dopamine transport (GO:0015872)2.46686549
82regulation of hippo signaling (GO:0035330)2.45073632
83negative regulation of T cell differentiation in thymus (GO:0033085)2.43341123
84regulation of mitotic spindle checkpoint (GO:1903504)2.42282179
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42282179
86ATP biosynthetic process (GO:0006754)2.42144454
87rRNA modification (GO:0000154)2.42097440
88positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.40099537
89cellular response to ATP (GO:0071318)2.38575757
90phosphatidylserine acyl-chain remodeling (GO:0036150)2.38007748
91maturation of SSU-rRNA (GO:0030490)2.37813232
92positive regulation of icosanoid secretion (GO:0032305)2.37591189
93protein localization to cilium (GO:0061512)2.35276658
94gamma-aminobutyric acid transport (GO:0015812)2.33775803
95positive regulation of oligodendrocyte differentiation (GO:0048714)2.33084986
96cellular biogenic amine catabolic process (GO:0042402)2.33062868
97amine catabolic process (GO:0009310)2.33062868
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.32179305
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.30221830
100reflex (GO:0060004)2.30178443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.92823967
2VDR_22108803_ChIP-Seq_LS180_Human3.48891030
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75081487
4EZH2_22144423_ChIP-Seq_EOC_Human2.68427920
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49530010
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.47867092
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.34885650
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.22913532
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21342881
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20652604
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17403393
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14029308
13EWS_26573619_Chip-Seq_HEK293_Human2.10072590
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.09660312
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07491478
16IGF1R_20145208_ChIP-Seq_DFB_Human2.06773268
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06678675
18GBX2_23144817_ChIP-Seq_PC3_Human2.01936326
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01799248
20FUS_26573619_Chip-Seq_HEK293_Human1.94238235
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92325259
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85281639
23ER_23166858_ChIP-Seq_MCF-7_Human1.83626970
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82107321
25P300_19829295_ChIP-Seq_ESCs_Human1.80019667
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76117526
27MYC_18940864_ChIP-ChIP_HL60_Human1.65966553
28TP53_22573176_ChIP-Seq_HFKS_Human1.64746178
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61761567
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59740558
31TAF15_26573619_Chip-Seq_HEK293_Human1.59588870
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55382682
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55282125
34VDR_23849224_ChIP-Seq_CD4+_Human1.51720405
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50769298
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49923332
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.49923332
38BCAT_22108803_ChIP-Seq_LS180_Human1.48542437
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47003233
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.45054777
41IRF1_19129219_ChIP-ChIP_H3396_Human1.44788364
42ELK1_19687146_ChIP-ChIP_HELA_Human1.44415986
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43021018
44NANOG_19829295_ChIP-Seq_ESCs_Human1.39972651
45SOX2_19829295_ChIP-Seq_ESCs_Human1.39972651
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.35513861
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34758030
48AR_20517297_ChIP-Seq_VCAP_Human1.31712034
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.30656249
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26404166
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26404166
52REST_21632747_ChIP-Seq_MESCs_Mouse1.24197759
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23181423
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.22801179
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22624310
56AR_21572438_ChIP-Seq_LNCaP_Human1.20808331
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.20418058
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.20044029
59CBP_20019798_ChIP-Seq_JUKART_Human1.18403034
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18403034
61TCF4_22108803_ChIP-Seq_LS180_Human1.18012211
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17144706
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16387295
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15723268
65AR_25329375_ChIP-Seq_VCAP_Human1.15620667
66HOXB7_26014856_ChIP-Seq_BT474_Human1.11651303
67NCOR_22424771_ChIP-Seq_293T_Human1.11273488
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11049071
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.10387059
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10210971
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.09775063
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09558186
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09343021
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09234401
75TCF4_23295773_ChIP-Seq_U87_Human1.08739195
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08162406
77P53_22387025_ChIP-Seq_ESCs_Mouse1.08035162
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07447214
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06580771
80GATA3_26560356_Chip-Seq_TH2_Human1.05527538
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.05060870
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.04029685
83STAT3_23295773_ChIP-Seq_U87_Human1.03579067
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.02313815
85MYC_19829295_ChIP-Seq_ESCs_Human1.02025296
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01874246
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00531296
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00497760
89RNF2_27304074_Chip-Seq_NSC_Mouse1.00225197
90RUNX2_22187159_ChIP-Seq_PCA_Human1.00023169
91ERA_21632823_ChIP-Seq_H3396_Human0.99482914
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99034316
93IRF8_22096565_ChIP-ChIP_GC-B_Human0.98975307
94FOXP3_21729870_ChIP-Seq_TREG_Human0.98944804
95SMAD4_21799915_ChIP-Seq_A2780_Human0.98903508
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97557638
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97408616
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.97104698
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96424806
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95392937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.07824976
2MP0008875_abnormal_xenobiotic_pharmacok2.92747950
3MP0008877_abnormal_DNA_methylation2.89203022
4MP0006072_abnormal_retinal_apoptosis2.56895199
5MP0004147_increased_porphyrin_level2.37788330
6MP0005551_abnormal_eye_electrophysiolog2.24786535
7MP0000569_abnormal_digit_pigmentation2.24130821
8MP0003195_calcinosis2.18628241
9MP0006292_abnormal_olfactory_placode2.10709769
10MP0004142_abnormal_muscle_tone2.10265157
11MP0008872_abnormal_physiological_respon2.08052114
12MP0004885_abnormal_endolymph2.07523549
13MP0001968_abnormal_touch/_nociception2.02771422
14MP0002736_abnormal_nociception_after2.01410015
15MP0002876_abnormal_thyroid_physiology2.00480254
16MP0005646_abnormal_pituitary_gland1.99904955
17MP0002138_abnormal_hepatobiliary_system1.90780552
18MP0002837_dystrophic_cardiac_calcinosis1.89147466
19MP0002102_abnormal_ear_morphology1.87779641
20MP0005671_abnormal_response_to1.87420988
21MP0009046_muscle_twitch1.84251234
22MP0002638_abnormal_pupillary_reflex1.83568106
23MP0005084_abnormal_gallbladder_morpholo1.83400821
24MP0002277_abnormal_respiratory_mucosa1.76793803
25MP0009745_abnormal_behavioral_response1.72940294
26MP0001501_abnormal_sleep_pattern1.69491429
27MP0002938_white_spotting1.68000289
28MP0005253_abnormal_eye_physiology1.67368535
29MP0002653_abnormal_ependyma_morphology1.61965742
30MP0000372_irregular_coat_pigmentation1.61768588
31MP0003011_delayed_dark_adaptation1.61137645
32MP0004133_heterotaxia1.59815802
33MP0005645_abnormal_hypothalamus_physiol1.58864162
34MP0002272_abnormal_nervous_system1.57359546
35MP0001485_abnormal_pinna_reflex1.54547401
36MP0009379_abnormal_foot_pigmentation1.53228991
37MP0003283_abnormal_digestive_organ1.50588309
38MP0004145_abnormal_muscle_electrophysio1.45064885
39MP0001529_abnormal_vocalization1.44120202
40MP0005174_abnormal_tail_pigmentation1.43010904
41MP0000631_abnormal_neuroendocrine_gland1.42078047
42MP0004043_abnormal_pH_regulation1.40643076
43MP0005075_abnormal_melanosome_morpholog1.30873162
44MP0002928_abnormal_bile_duct1.29322504
45MP0003878_abnormal_ear_physiology1.22353337
46MP0005377_hearing/vestibular/ear_phenot1.22353337
47MP0001486_abnormal_startle_reflex1.20267504
48MP0001905_abnormal_dopamine_level1.19551236
49MP0002064_seizures1.17156109
50MP0005389_reproductive_system_phenotype1.15969077
51MP0003646_muscle_fatigue1.14666558
52MP0002572_abnormal_emotion/affect_behav1.14232130
53MP0001986_abnormal_taste_sensitivity1.14012501
54MP0001919_abnormal_reproductive_system1.13618540
55MP0008058_abnormal_DNA_repair1.11537993
56MP0005085_abnormal_gallbladder_physiolo1.07728902
57MP0002822_catalepsy1.04654028
58MP0002733_abnormal_thermal_nociception1.04634442
59MP0001970_abnormal_pain_threshold1.04534390
60MP0000685_abnormal_immune_system1.03429035
61MP0002751_abnormal_autonomic_nervous1.02695514
62MP0002735_abnormal_chemical_nociception1.02231407
63MP0003890_abnormal_embryonic-extraembry1.01359708
64MP0000427_abnormal_hair_cycle1.00135024
65MP0003787_abnormal_imprinting0.99993083
66MP0003252_abnormal_bile_duct0.98297204
67MP0004742_abnormal_vestibular_system0.97450249
68MP0005195_abnormal_posterior_eye0.96033284
69MP0002557_abnormal_social/conspecific_i0.95200962
70MP0003119_abnormal_digestive_system0.94670484
71MP0002160_abnormal_reproductive_system0.92959696
72MP0002067_abnormal_sensory_capabilities0.92427892
73MP0005167_abnormal_blood-brain_barrier0.91936105
74MP0001293_anophthalmia0.90628176
75MP0001835_abnormal_antigen_presentation0.90100707
76MP0003718_maternal_effect0.89029083
77MP0002095_abnormal_skin_pigmentation0.88862110
78MP0002693_abnormal_pancreas_physiology0.88299974
79MP0002148_abnormal_hypersensitivity_rea0.87023784
80MP0005332_abnormal_amino_acid0.86836291
81MP0002163_abnormal_gland_morphology0.83490716
82MP0008995_early_reproductive_senescence0.83131881
83MP0004924_abnormal_behavior0.82445515
84MP0005386_behavior/neurological_phenoty0.82445515
85MP0002234_abnormal_pharynx_morphology0.81432833
86MP0005410_abnormal_fertilization0.79369997
87MP0000026_abnormal_inner_ear0.77905957
88MP0004215_abnormal_myocardial_fiber0.77028396
89MP0001984_abnormal_olfaction0.76510993
90MP0005379_endocrine/exocrine_gland_phen0.76132944
91MP0006036_abnormal_mitochondrial_physio0.75812387
92MP0006276_abnormal_autonomic_nervous0.75285947
93MP0002752_abnormal_somatic_nervous0.75051093
94MP0002909_abnormal_adrenal_gland0.74496451
95MP0000230_abnormal_systemic_arterial0.74342544
96MP0005365_abnormal_bile_salt0.73854415
97MP0001800_abnormal_humoral_immune0.73528735
98MP0001502_abnormal_circadian_rhythm0.73092702
99MP0003786_premature_aging0.72403624
100MP0001764_abnormal_homeostasis0.71146107

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.54987918
2Pancreatic cysts (HP:0001737)4.12751406
3Congenital, generalized hypertrichosis (HP:0004540)3.91001676
4Pancreatic fibrosis (HP:0100732)3.88572924
5Molar tooth sign on MRI (HP:0002419)3.63793674
6Abnormality of midbrain morphology (HP:0002418)3.63793674
7True hermaphroditism (HP:0010459)3.59229337
8Type II lissencephaly (HP:0007260)3.36517182
9Nephronophthisis (HP:0000090)3.34756970
10Mitochondrial inheritance (HP:0001427)3.11324819
11Acute necrotizing encephalopathy (HP:0006965)3.07858426
12Increased CSF lactate (HP:0002490)3.00739978
13Abnormality of the renal cortex (HP:0011035)2.93170447
14Increased hepatocellular lipid droplets (HP:0006565)2.78895707
15Abolished electroretinogram (ERG) (HP:0000550)2.77996105
16Lipid accumulation in hepatocytes (HP:0006561)2.76914220
17Abnormality of the renal medulla (HP:0100957)2.75925326
18Large for gestational age (HP:0001520)2.70118077
19Acute encephalopathy (HP:0006846)2.68185542
20Progressive macrocephaly (HP:0004481)2.67541495
21Renal cortical cysts (HP:0000803)2.64259260
22Attenuation of retinal blood vessels (HP:0007843)2.59550329
23Abnormal mitochondria in muscle tissue (HP:0008316)2.59216415
24IgG deficiency (HP:0004315)2.54769356
25Hepatocellular necrosis (HP:0001404)2.50971346
26Abnormality of the pons (HP:0007361)2.50063779
273-Methylglutaconic aciduria (HP:0003535)2.49926860
28Pendular nystagmus (HP:0012043)2.47340178
29Abnormal rod and cone electroretinograms (HP:0008323)2.45889506
30Sclerocornea (HP:0000647)2.40371916
31Hypoplasia of the pons (HP:0012110)2.39690185
32Absent/shortened dynein arms (HP:0200106)2.39141492
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.39141492
34Cystic liver disease (HP:0006706)2.38310151
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35794417
36Abnormality of alanine metabolism (HP:0010916)2.35794417
37Hyperalaninemia (HP:0003348)2.35794417
38Concave nail (HP:0001598)2.35322995
39Hepatic necrosis (HP:0002605)2.33800383
40Optic disc pallor (HP:0000543)2.31939920
41Polydipsia (HP:0001959)2.31685178
42Abnormal drinking behavior (HP:0030082)2.31685178
43Tubular atrophy (HP:0000092)2.28732182
44Abnormal respiratory epithelium morphology (HP:0012253)2.26660415
45Abnormal respiratory motile cilium morphology (HP:0005938)2.26660415
46Inability to walk (HP:0002540)2.25010824
47Chronic hepatic failure (HP:0100626)2.22296116
48Aplasia/hypoplasia of the uterus (HP:0008684)2.21520245
49Medial flaring of the eyebrow (HP:0010747)2.20099897
50Abnormal biliary tract physiology (HP:0012439)2.18344996
51Bile duct proliferation (HP:0001408)2.18344996
52Methylmalonic acidemia (HP:0002912)2.18042755
53Type 2 muscle fiber atrophy (HP:0003554)2.15138019
54Methylmalonic aciduria (HP:0012120)2.10665550
55Abnormal number of erythroid precursors (HP:0012131)2.10304115
56Abnormality of B cell number (HP:0010975)2.09184469
57Bilateral microphthalmos (HP:0007633)2.07215799
58Abnormal ciliary motility (HP:0012262)2.05399078
59Anencephaly (HP:0002323)2.03623446
60Stomatitis (HP:0010280)2.03456463
61Furrowed tongue (HP:0000221)2.02388006
62Cerebellar dysplasia (HP:0007033)2.00676262
63Increased corneal curvature (HP:0100692)1.99784946
64Keratoconus (HP:0000563)1.99784946
65Rib fusion (HP:0000902)1.97928025
66Focal motor seizures (HP:0011153)1.97912817
67Chorioretinal atrophy (HP:0000533)1.96127778
68Renal Fanconi syndrome (HP:0001994)1.96040312
69Increased serum lactate (HP:0002151)1.94872805
70Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94845774
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93723096
72Hyperventilation (HP:0002883)1.93035623
73Thyroiditis (HP:0100646)1.92385273
74Progressive cerebellar ataxia (HP:0002073)1.91994395
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.91832935
76Polyuria (HP:0000103)1.89714332
77B lymphocytopenia (HP:0010976)1.89559677
78Abnormal respiratory motile cilium physiology (HP:0012261)1.87657547
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.86784697
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86655692
81Hypothermia (HP:0002045)1.86279834
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.85782136
83Optic nerve hypoplasia (HP:0000609)1.83997459
84Delayed CNS myelination (HP:0002188)1.83659969
85Abnormality of the renal collecting system (HP:0004742)1.82489556
86Severe muscular hypotonia (HP:0006829)1.82488441
87Cerebral edema (HP:0002181)1.81849185
88Duplicated collecting system (HP:0000081)1.81119439
89Exertional dyspnea (HP:0002875)1.79733598
90Congenital hepatic fibrosis (HP:0002612)1.79651949
91Progressive inability to walk (HP:0002505)1.79519282
92Male pseudohermaphroditism (HP:0000037)1.76866602
93Lissencephaly (HP:0001339)1.76854088
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76516362
95Asplenia (HP:0001746)1.75391534
96Hypoproteinemia (HP:0003075)1.75037034
97Abnormality of cells of the erythroid lineage (HP:0012130)1.74200217
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.73769396
99Severe combined immunodeficiency (HP:0004430)1.73248261
100Short tibia (HP:0005736)1.72281083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.45403709
2TLK13.43772985
3ADRBK23.34076088
4ZAK3.27878138
5TXK2.98522624
6BMPR1B2.83359707
7MAP4K22.80294253
8PNCK2.76138662
9GRK12.75390872
10WNK42.65155229
11MAPK152.23928484
12TAOK32.07085369
13NUAK12.05974708
14ACVR1B2.04984141
15TSSK62.01798145
16WNK31.83057660
17TIE11.76664227
18DAPK21.76209142
19PINK11.54659144
20OXSR11.47783335
21MKNK21.45811651
22INSRR1.45730096
23NME11.45659363
24MAPK131.40863862
25BCKDK1.39776465
26VRK11.39321998
27MST41.38637793
28TAF11.35588649
29STK391.34055266
30TGFBR11.26542607
31PHKG21.21534045
32PHKG11.21534045
33EIF2AK31.17140922
34ADRBK11.14644032
35CASK1.14147751
36WEE11.11624670
37MKNK11.03253959
38DYRK21.02268258
39MAPKAPK30.97990703
40CAMKK20.96527804
41VRK20.94544944
42MAP3K40.86335017
43IKBKB0.84093400
44NTRK20.82778777
45KIT0.81444259
46PRKCG0.79724874
47STK38L0.78206536
48PLK30.76324865
49TNIK0.74504743
50TEC0.74276501
51SRPK10.71931338
52MAP2K20.71833164
53NTRK30.70337655
54RPS6KA50.68619692
55FES0.67629385
56ITK0.67527319
57MAP4K10.65264961
58GRK70.64700173
59MAPKAPK50.64566951
60IKBKE0.62930223
61PRKCQ0.62485534
62PASK0.60720529
63MAP2K60.59605384
64PRKCE0.58750201
65PAK30.56636292
66PRKCI0.55687642
67SYK0.52178023
68CHUK0.51059810
69CSNK1G10.48532501
70EIF2AK20.48460163
71CDC70.47899103
72EIF2AK10.46441946
73STK110.46159399
74CAMK10.45712315
75CSNK1G20.45430943
76PIK3CA0.45022126
77PKN10.40432875
78CSNK1G30.39804616
79CDK80.39638278
80OBSCN0.39387768
81PRKACA0.39047707
82FGFR20.38918158
83WNK10.38259141
84LCK0.38132311
85CAMK2A0.37123896
86GRK50.36763156
87LYN0.36353422
88IGF1R0.34572343
89IRAK10.33775790
90PLK20.32348313
91MUSK0.32178706
92PTK2B0.32140711
93PRKCA0.31984035
94PLK40.31687731
95NEK20.31230691
96GRK60.29993411
97FLT30.29690914
98CDK30.28566076
99CSF1R0.27794764
100IRAK40.27614029

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.13379516
2Caffeine metabolism_Homo sapiens_hsa002322.86080405
3Linoleic acid metabolism_Homo sapiens_hsa005912.51451126
4Phototransduction_Homo sapiens_hsa047442.48243964
5Proteasome_Homo sapiens_hsa030502.45003528
6Parkinsons disease_Homo sapiens_hsa050122.43690144
7Nitrogen metabolism_Homo sapiens_hsa009102.42644667
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37558101
9Protein export_Homo sapiens_hsa030602.30621810
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22843919
11RNA polymerase_Homo sapiens_hsa030202.20103829
12Ribosome_Homo sapiens_hsa030102.04125827
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.98283909
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.93183989
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89064216
16Homologous recombination_Homo sapiens_hsa034401.74903127
17Asthma_Homo sapiens_hsa053101.71762004
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69478096
19Selenocompound metabolism_Homo sapiens_hsa004501.62059658
20Alzheimers disease_Homo sapiens_hsa050101.60514534
21Basal transcription factors_Homo sapiens_hsa030221.57816884
22Huntingtons disease_Homo sapiens_hsa050161.57770475
23Tryptophan metabolism_Homo sapiens_hsa003801.56934594
24Cardiac muscle contraction_Homo sapiens_hsa042601.56311583
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51014199
26Butanoate metabolism_Homo sapiens_hsa006501.49749795
27Primary immunodeficiency_Homo sapiens_hsa053401.47755389
28Ether lipid metabolism_Homo sapiens_hsa005651.47402417
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45389314
30RNA degradation_Homo sapiens_hsa030181.44151125
31Nicotine addiction_Homo sapiens_hsa050331.43850141
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36706254
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34905673
34One carbon pool by folate_Homo sapiens_hsa006701.34772240
35Fanconi anemia pathway_Homo sapiens_hsa034601.29913039
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28832931
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28717135
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27452337
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24595495
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21699604
41Type I diabetes mellitus_Homo sapiens_hsa049401.18175718
42Allograft rejection_Homo sapiens_hsa053301.14910870
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10733701
44Autoimmune thyroid disease_Homo sapiens_hsa053201.09583214
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09083073
46Chemical carcinogenesis_Homo sapiens_hsa052041.08633763
47Propanoate metabolism_Homo sapiens_hsa006401.05439647
48Peroxisome_Homo sapiens_hsa041460.99151372
49Arachidonic acid metabolism_Homo sapiens_hsa005900.98622177
50Graft-versus-host disease_Homo sapiens_hsa053320.96257975
51Olfactory transduction_Homo sapiens_hsa047400.95793786
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95511175
53Retinol metabolism_Homo sapiens_hsa008300.93017484
54Taste transduction_Homo sapiens_hsa047420.92226335
55Purine metabolism_Homo sapiens_hsa002300.86107630
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85871718
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.85269196
58Nucleotide excision repair_Homo sapiens_hsa034200.85157162
59Sulfur metabolism_Homo sapiens_hsa009200.84357873
60Morphine addiction_Homo sapiens_hsa050320.80689189
61Sulfur relay system_Homo sapiens_hsa041220.78789687
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75512008
63ABC transporters_Homo sapiens_hsa020100.73619838
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.71363957
65Antigen processing and presentation_Homo sapiens_hsa046120.70792126
66Fat digestion and absorption_Homo sapiens_hsa049750.69499538
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68081349
68Collecting duct acid secretion_Homo sapiens_hsa049660.65757578
69Rheumatoid arthritis_Homo sapiens_hsa053230.65230099
70Pyrimidine metabolism_Homo sapiens_hsa002400.65091281
71Insulin secretion_Homo sapiens_hsa049110.62376160
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61964295
73Vitamin digestion and absorption_Homo sapiens_hsa049770.59657189
74Serotonergic synapse_Homo sapiens_hsa047260.59518468
75Metabolic pathways_Homo sapiens_hsa011000.57459518
76GABAergic synapse_Homo sapiens_hsa047270.57108920
77Glycerolipid metabolism_Homo sapiens_hsa005610.55075687
78Ovarian steroidogenesis_Homo sapiens_hsa049130.52819244
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51417550
80Hematopoietic cell lineage_Homo sapiens_hsa046400.49683315
81Circadian entrainment_Homo sapiens_hsa047130.49203626
82Glutamatergic synapse_Homo sapiens_hsa047240.48570508
83Salivary secretion_Homo sapiens_hsa049700.47178098
84Regulation of autophagy_Homo sapiens_hsa041400.46885794
85beta-Alanine metabolism_Homo sapiens_hsa004100.44325531
86Mismatch repair_Homo sapiens_hsa034300.42335435
87Mineral absorption_Homo sapiens_hsa049780.40345924
88Histidine metabolism_Homo sapiens_hsa003400.39570358
89Calcium signaling pathway_Homo sapiens_hsa040200.39549077
90Spliceosome_Homo sapiens_hsa030400.38238758
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37986805
92Folate biosynthesis_Homo sapiens_hsa007900.35857537
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34505496
94Steroid biosynthesis_Homo sapiens_hsa001000.34241525
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34089018
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33353676
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32515403
98RNA transport_Homo sapiens_hsa030130.32367214
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.31721893
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30747172

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