HSPD1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)7.21030057
2sequestering of extracellular ligand from receptor (GO:0035581)5.74383631
3somite rostral/caudal axis specification (GO:0032525)4.52304653
4negative regulation of activin receptor signaling pathway (GO:0032926)4.44265223
5response to follicle-stimulating hormone (GO:0032354)4.33441258
6estrogen metabolic process (GO:0008210)4.22261066
7endoderm formation (GO:0001706)4.20644034
8pericardium development (GO:0060039)4.20260095
9otic vesicle formation (GO:0030916)4.07744176
10nodal signaling pathway (GO:0038092)3.99904983
11regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.97377341
12cell migration involved in gastrulation (GO:0042074)3.95505703
13signal transduction involved in regulation of gene expression (GO:0023019)3.91517978
14regulation of mesoderm development (GO:2000380)3.85351209
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.84292654
16genitalia morphogenesis (GO:0035112)3.83814209
17primitive streak formation (GO:0090009)3.81296131
18regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.67884030
19mitotic sister chromatid cohesion (GO:0007064)3.66949272
20centriole replication (GO:0007099)3.53960070
21dorsal/ventral axis specification (GO:0009950)3.46043093
22anterior/posterior axis specification, embryo (GO:0008595)3.43922271
23embryonic foregut morphogenesis (GO:0048617)3.43194166
24anterior/posterior axis specification (GO:0009948)3.40740285
25regulation of acyl-CoA biosynthetic process (GO:0050812)3.40696743
26neuron fate determination (GO:0048664)3.39237706
27prostate gland growth (GO:0060736)3.32796916
28embryonic axis specification (GO:0000578)3.32434376
29regulation of transforming growth factor beta2 production (GO:0032909)3.24275483
30cellular response to cholesterol (GO:0071397)3.24202886
31cellular response to sterol (GO:0036315)3.23385377
32regulation of activin receptor signaling pathway (GO:0032925)3.23325259
33kinetochore organization (GO:0051383)3.22734184
34positive regulation of macrophage activation (GO:0043032)3.21686157
35extracellular negative regulation of signal transduction (GO:1900116)3.19880215
36extracellular regulation of signal transduction (GO:1900115)3.19880215
37embryonic retina morphogenesis in camera-type eye (GO:0060059)3.18734361
38embryonic pattern specification (GO:0009880)3.14930553
39regulation of non-canonical Wnt signaling pathway (GO:2000050)3.14380114
40kinetochore assembly (GO:0051382)3.06916728
41positive regulation of cardiac muscle cell proliferation (GO:0060045)3.01096049
42ER overload response (GO:0006983)3.00318220
43regulation of centriole replication (GO:0046599)2.99872394
44UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97799707
45androgen biosynthetic process (GO:0006702)2.97603128
46regulation of cofactor metabolic process (GO:0051193)2.91375740
47regulation of coenzyme metabolic process (GO:0051196)2.91375740
48neural tube formation (GO:0001841)2.89219823
49replication fork processing (GO:0031297)2.89107832
50activin receptor signaling pathway (GO:0032924)2.88012357
51gastrulation with mouth forming second (GO:0001702)2.86523246
52regulation of gonadotropin secretion (GO:0032276)2.86327655
53androgen metabolic process (GO:0008209)2.82747288
54phospholipid scrambling (GO:0017121)2.80088096
55positive regulation of cardiac muscle tissue growth (GO:0055023)2.79834857
56negative regulation of hormone biosynthetic process (GO:0032353)2.79697103
57atrial cardiac muscle cell action potential (GO:0086014)2.79665025
58CENP-A containing nucleosome assembly (GO:0034080)2.79381085
59regulation of relaxation of muscle (GO:1901077)2.78083162
60gastrulation (GO:0007369)2.77119073
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76139854
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73651897
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.73651897
64regulation of translation, ncRNA-mediated (GO:0045974)2.73651897
65regulation of sulfur metabolic process (GO:0042762)2.71247391
66positive regulation of cardiac muscle tissue development (GO:0055025)2.68794936
67protein prenylation (GO:0018342)2.65789205
68prenylation (GO:0097354)2.65789205
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63082234
70sequestering of actin monomers (GO:0042989)2.61924794
71chromatin remodeling at centromere (GO:0031055)2.61645473
72neuron cell-cell adhesion (GO:0007158)2.60382915
73glucocorticoid biosynthetic process (GO:0006704)2.60321760
74embryonic digestive tract morphogenesis (GO:0048557)2.59395065
75SMAD protein signal transduction (GO:0060395)2.59187706
76response to pheromone (GO:0019236)2.58227957
77establishment of protein localization to Golgi (GO:0072600)2.58100549
78mesenchymal cell differentiation (GO:0048762)2.55555996
79centrosome organization (GO:0051297)2.54938983
80response to sterol (GO:0036314)2.54249035
81histone mRNA catabolic process (GO:0071044)2.53442259
82microtubule organizing center organization (GO:0031023)2.50804732
83limb bud formation (GO:0060174)2.50713656
84regulation of cell communication by electrical coupling (GO:0010649)2.49705008
85protein targeting to Golgi (GO:0000042)2.46841564
86DNA replication-dependent nucleosome organization (GO:0034723)2.45896651
87DNA replication-dependent nucleosome assembly (GO:0006335)2.45896651
88response to cholesterol (GO:0070723)2.44409964
89pancreas development (GO:0031016)2.44057473
90response to BMP (GO:0071772)2.43984848
91cellular response to BMP stimulus (GO:0071773)2.43984848
92positive regulation of heart growth (GO:0060421)2.43540133
93keratinocyte development (GO:0003334)2.43398604
94nuclear pore complex assembly (GO:0051292)2.43020860
95regulation of cardioblast differentiation (GO:0051890)2.41416337
96histone exchange (GO:0043486)2.39767156
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.35150829
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.35150829
99interkinetic nuclear migration (GO:0022027)2.31333207
100retrograde transport, vesicle recycling within Golgi (GO:0000301)2.30883288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.11990494
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.99783946
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93615557
4GBX2_23144817_ChIP-Seq_PC3_Human2.30908972
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26653651
6EWS_26573619_Chip-Seq_HEK293_Human2.18110718
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16488489
8P300_19829295_ChIP-Seq_ESCs_Human2.08074145
9SMAD3_21741376_ChIP-Seq_EPCs_Human2.06348317
10TAF15_26573619_Chip-Seq_HEK293_Human2.04246024
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03864313
12SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.97250467
13FUS_26573619_Chip-Seq_HEK293_Human1.95090912
14VDR_22108803_ChIP-Seq_LS180_Human1.94485538
15SMAD3_21741376_ChIP-Seq_HESCs_Human1.93870530
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.91201085
17ELK1_19687146_ChIP-ChIP_HELA_Human1.87285433
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78370147
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.77253324
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74515296
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72764957
22ZNF274_21170338_ChIP-Seq_K562_Hela1.71356691
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70838830
24ER_23166858_ChIP-Seq_MCF-7_Human1.70131216
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.67675556
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.66492527
27SMAD4_21799915_ChIP-Seq_A2780_Human1.66115352
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63197051
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63104209
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.62094233
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61361084
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58572463
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57996105
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57886545
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56668777
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56595899
37E2F7_22180533_ChIP-Seq_HELA_Human1.54858531
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54332172
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53551352
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.50109756
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49930554
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49837047
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49777299
44CBP_20019798_ChIP-Seq_JUKART_Human1.49777299
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48164584
46SMAD4_21741376_ChIP-Seq_HESCs_Human1.45994615
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.44196622
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43425531
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42821246
50BCAT_22108803_ChIP-Seq_LS180_Human1.42443396
51STAT3_23295773_ChIP-Seq_U87_Human1.41739908
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40984915
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.40890003
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40526834
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.39286066
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38903798
57TP53_16413492_ChIP-PET_HCT116_Human1.37891108
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37409524
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36589342
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.35795469
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34858480
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34079841
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34079841
64TP53_18474530_ChIP-ChIP_U2OS_Human1.33868809
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33444416
66P53_22387025_ChIP-Seq_ESCs_Mouse1.30718558
67TCF4_22108803_ChIP-Seq_LS180_Human1.28419140
68AR_25329375_ChIP-Seq_VCAP_Human1.27412849
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27203064
70TCF4_23295773_ChIP-Seq_U87_Human1.26748567
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.26438922
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26101897
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26046565
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24674152
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.24528128
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23401550
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23401550
78CDX2_22108803_ChIP-Seq_LS180_Human1.22255743
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21452031
80BRD4_25478319_ChIP-Seq_HGPS_Human1.20251369
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19947301
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19222345
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.18935844
84SOX2_19829295_ChIP-Seq_ESCs_Human1.18210672
85NANOG_19829295_ChIP-Seq_ESCs_Human1.18210672
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17249230
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.17141698
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16114281
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15444489
90RUNX2_22187159_ChIP-Seq_PCA_Human1.14743685
91P300_18555785_Chip-Seq_ESCs_Mouse1.14706894
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.14293213
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14141592
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.13487283
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.11006697
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.07725665
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05593408
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05305245
99AR_21909140_ChIP-Seq_LNCAP_Human1.04721932
100AHR_22903824_ChIP-Seq_MCF-7_Human1.04473297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry5.66277458
2MP0009697_abnormal_copulation3.50086191
3MP0008995_early_reproductive_senescence2.65804351
4MP0003941_abnormal_skin_development2.63178139
5MP0002254_reproductive_system_inflammat2.60397287
6MP0003283_abnormal_digestive_organ2.46349092
7MP0002102_abnormal_ear_morphology2.41558359
8MP0002638_abnormal_pupillary_reflex2.38570204
9MP0008057_abnormal_DNA_replication2.38468496
10MP0004133_heterotaxia2.30523042
11MP0004145_abnormal_muscle_electrophysio2.15252544
12MP0003937_abnormal_limbs/digits/tail_de2.07162233
13MP0003119_abnormal_digestive_system1.96775666
14MP0003950_abnormal_plasma_membrane1.81576895
15MP0003385_abnormal_body_wall1.81382683
16MP0004215_abnormal_myocardial_fiber1.80559778
17MP0008058_abnormal_DNA_repair1.76762349
18MP0000372_irregular_coat_pigmentation1.68288302
19MP0005379_endocrine/exocrine_gland_phen1.67806059
20MP0003195_calcinosis1.65066238
21MP0003786_premature_aging1.60739376
22MP0009780_abnormal_chondrocyte_physiolo1.52747520
23MP0006276_abnormal_autonomic_nervous1.49904876
24MP0006072_abnormal_retinal_apoptosis1.45646226
25MP0001293_anophthalmia1.44022813
26MP0002084_abnormal_developmental_patter1.40156419
27MP0002736_abnormal_nociception_after1.38230061
28MP0005551_abnormal_eye_electrophysiolog1.35973360
29MP0004885_abnormal_endolymph1.34900620
30MP0002233_abnormal_nose_morphology1.32064126
31MP0002938_white_spotting1.31915324
32MP0003567_abnormal_fetal_cardiomyocyte1.30016399
33MP0004957_abnormal_blastocyst_morpholog1.29594869
34MP0003880_abnormal_central_pattern1.27940287
35MP0000462_abnormal_digestive_system1.26207424
36MP0004085_abnormal_heartbeat1.25381882
37MP0003935_abnormal_craniofacial_develop1.25304574
38MP0008775_abnormal_heart_ventricle1.25035514
39MP0000647_abnormal_sebaceous_gland1.24884145
40MP0006292_abnormal_olfactory_placode1.24580878
41MP0000639_abnormal_adrenal_gland1.23444631
42MP0006054_spinal_hemorrhage1.22433559
43MP0001286_abnormal_eye_development1.20824504
44MP0001984_abnormal_olfaction1.19212222
45MP0003936_abnormal_reproductive_system1.19179627
46MP0001299_abnormal_eye_distance/1.14544180
47MP0001666_abnormal_nutrient_absorption1.14212633
48MP0005187_abnormal_penis_morphology1.12371977
49MP0002127_abnormal_cardiovascular_syste1.11538599
50MP0000427_abnormal_hair_cycle1.10690640
51MP0005253_abnormal_eye_physiology1.10182410
52MP0000383_abnormal_hair_follicle1.09394950
53MP0002697_abnormal_eye_size1.09051327
54MP0010386_abnormal_urinary_bladder1.08593159
55MP0002163_abnormal_gland_morphology1.08247405
56MP0002088_abnormal_embryonic_growth/wei1.07018128
57MP0001672_abnormal_embryogenesis/_devel1.06860083
58MP0005380_embryogenesis_phenotype1.06860083
59MP0009703_decreased_birth_body1.06292082
60MP0003984_embryonic_growth_retardation1.05622381
61MP0004272_abnormal_basement_membrane1.02735677
62MP0000013_abnormal_adipose_tissue1.01952626
63MP0005645_abnormal_hypothalamus_physiol1.01738018
64MP0002109_abnormal_limb_morphology1.00370337
65MP0000631_abnormal_neuroendocrine_gland0.98365430
66MP0002234_abnormal_pharynx_morphology0.96135939
67MP0010094_abnormal_chromosome_stability0.94313311
68MP0003077_abnormal_cell_cycle0.92942971
69MP0000569_abnormal_digit_pigmentation0.90815464
70MP0002086_abnormal_extraembryonic_tissu0.90666640
71MP0005389_reproductive_system_phenotype0.89484355
72MP0002160_abnormal_reproductive_system0.88918074
73MP0008932_abnormal_embryonic_tissue0.88910571
74MP0001727_abnormal_embryo_implantation0.88584363
75MP0003943_abnormal_hepatobiliary_system0.87000082
76MP0010352_gastrointestinal_tract_polyps0.86856718
77MP0004084_abnormal_cardiac_muscle0.86655513
78MP0001919_abnormal_reproductive_system0.85157400
79MP0005647_abnormal_sex_gland0.84215088
80MP0002837_dystrophic_cardiac_calcinosis0.83742684
81MP0002177_abnormal_outer_ear0.77770835
82MP0001697_abnormal_embryo_size0.77205754
83MP0005391_vision/eye_phenotype0.76340399
84MP0002282_abnormal_trachea_morphology0.75310237
85MP0002085_abnormal_embryonic_tissue0.75156067
86MP0003115_abnormal_respiratory_system0.72901953
87MP0010368_abnormal_lymphatic_system0.72619972
88MP0002115_abnormal_skeleton_extremities0.70665554
89MP0002925_abnormal_cardiovascular_devel0.70451190
90MP0001968_abnormal_touch/_nociception0.70414327
91MP0002557_abnormal_social/conspecific_i0.70305944
92MP0006035_abnormal_mitochondrial_morpho0.69941571
93MP0002111_abnormal_tail_morphology0.69301494
94MP0003137_abnormal_impulse_conducting0.69093052
95MP0002210_abnormal_sex_determination0.66975238
96MP0001879_abnormal_lymphatic_vessel0.66596167
97MP0003755_abnormal_palate_morphology0.65841896
98MP0008004_abnormal_stomach_pH0.65456417
99MP0010329_abnormal_lipoprotein_level0.65361290
100MP0000428_abnormal_craniofacial_morphol0.64809652

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the ischium (HP:0003174)4.31847415
2Volvulus (HP:0002580)3.69385626
3Double outlet right ventricle (HP:0001719)3.45605993
4Congenital malformation of the right heart (HP:0011723)3.45605993
5Abnormal pancreas size (HP:0012094)3.29764653
6Abnormality of the renal cortex (HP:0011035)3.17136255
7Renal cortical cysts (HP:0000803)3.14907663
8Intestinal atresia (HP:0011100)3.13721309
9Progressive inability to walk (HP:0002505)2.76441334
10Oligodactyly (hands) (HP:0001180)2.72470839
11Hypoplastic pelvis (HP:0008839)2.67317265
12Hypoplastic labia majora (HP:0000059)2.65246152
13Conjugated hyperbilirubinemia (HP:0002908)2.56016084
14Pancreatic islet-cell hyperplasia (HP:0004510)2.42696596
15Aplasia/Hypoplasia of the tibia (HP:0005772)2.38416060
16Abnormality of the labia majora (HP:0012881)2.38303617
17Neoplasm of the small intestine (HP:0100833)2.36269025
18Small hand (HP:0200055)2.32956177
19Bifid tongue (HP:0010297)2.31038742
20Hypoplastic ischia (HP:0003175)2.30614264
21Papillary thyroid carcinoma (HP:0002895)2.30435481
22Abnormality of the right ventricle (HP:0001707)2.29086628
23Abnormality of the nasal septum (HP:0000419)2.26975324
24Abnormality of chromosome stability (HP:0003220)2.25432474
25Anal stenosis (HP:0002025)2.25298962
26Entropion (HP:0000621)2.24896103
27Abnormal umbilical cord blood vessels (HP:0011403)2.22054922
28Single umbilical artery (HP:0001195)2.22054922
29Abnormality of the fetal cardiovascular system (HP:0010948)2.22054922
30Labial hypoplasia (HP:0000066)2.20564955
31Hip dysplasia (HP:0001385)2.20198782
32Hyperventilation (HP:0002883)2.15915006
33Chorioretinal atrophy (HP:0000533)2.13244544
34Abnormality of incisor morphology (HP:0011063)2.11145723
35Long clavicles (HP:0000890)2.09844922
36Shawl scrotum (HP:0000049)2.09493714
37Colon cancer (HP:0003003)2.09485626
38Abnormality of the aortic arch (HP:0012303)2.06469373
39Methylmalonic acidemia (HP:0002912)2.04109129
40Absent radius (HP:0003974)2.04077960
41Abnormality of the renal medulla (HP:0100957)2.00660473
42Aqueductal stenosis (HP:0002410)1.94669767
43Hypoplastic female external genitalia (HP:0012815)1.94491540
44Aplasia/Hypoplasia of the uvula (HP:0010293)1.91419619
45Knee flexion contracture (HP:0006380)1.91352411
46Short tibia (HP:0005736)1.91288851
47Chromsome breakage (HP:0040012)1.90644215
48Transposition of the great arteries (HP:0001669)1.90375420
49Abnormal connection of the cardiac segments (HP:0011545)1.90375420
50Abnormal ventriculo-arterial connection (HP:0011563)1.90375420
51Abnormal auditory evoked potentials (HP:0006958)1.89472242
52Absent forearm bone (HP:0003953)1.87238702
53Aplasia involving forearm bones (HP:0009822)1.87238702
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83956486
55Abnormality of alanine metabolism (HP:0010916)1.83956486
56Hyperalaninemia (HP:0003348)1.83956486
57Abnormality of midbrain morphology (HP:0002418)1.83517926
58Molar tooth sign on MRI (HP:0002419)1.83517926
59Abnormality of the parathyroid morphology (HP:0011766)1.83388106
60Pancreatic cysts (HP:0001737)1.81262228
61Thyroid-stimulating hormone excess (HP:0002925)1.79110969
62Anophthalmia (HP:0000528)1.78647969
63Chin dimple (HP:0010751)1.78604560
64Glioma (HP:0009733)1.78499662
65Nephrogenic diabetes insipidus (HP:0009806)1.77946355
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77455542
67Pheochromocytoma (HP:0002666)1.76729239
68Enlarged kidneys (HP:0000105)1.75819880
69Pulmonic stenosis (HP:0001642)1.75697500
70Secondary amenorrhea (HP:0000869)1.72715454
71Abnormal biliary tract morphology (HP:0012440)1.71931508
72Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.71055247
73Overlapping toe (HP:0001845)1.70245317
74Abnormality of the duodenum (HP:0002246)1.69654569
75Patent foramen ovale (HP:0001655)1.69616273
76Abnormality of the ileum (HP:0001549)1.69030129
77Neoplasm of the rectum (HP:0100743)1.68474485
78Missing ribs (HP:0000921)1.68364580
79Astrocytoma (HP:0009592)1.67812366
80Abnormality of the astrocytes (HP:0100707)1.67812366
81Rhabdomyosarcoma (HP:0002859)1.67358059
82Short chin (HP:0000331)1.65420117
83Neonatal respiratory distress (HP:0002643)1.64938901
84Thyroid carcinoma (HP:0002890)1.64883205
85Pancreatic fibrosis (HP:0100732)1.64324972
86Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63453387
87Drooling (HP:0002307)1.62177615
88Hyperaldosteronism (HP:0000859)1.62053157
89Abnormality of the labia (HP:0000058)1.62036256
90Renal salt wasting (HP:0000127)1.61948787
91Cupped ear (HP:0000378)1.61457340
92Absent eyebrow (HP:0002223)1.61343803
93Neuroendocrine neoplasm (HP:0100634)1.60453286
94True hermaphroditism (HP:0010459)1.60132338
95Abnormal lung lobation (HP:0002101)1.59783957
96Hypoplastic ilia (HP:0000946)1.58638019
97Hypoglycemic coma (HP:0001325)1.58190404
98Nephronophthisis (HP:0000090)1.57445658
99Meckel diverticulum (HP:0002245)1.57352902
100Inability to walk (HP:0002540)1.56364546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.10653768
2ACVR1B3.94474123
3NUAK13.46297528
4PBK3.29718653
5BMPR1B3.02360873
6ERBB42.99722500
7TRIM282.98576282
8LATS12.91899470
9WNK32.79151503
10PDK22.53033277
11FRK2.51055351
12MAP3K42.33834646
13PNCK2.19659569
14MST42.10479906
15OBSCN1.98416681
16TNIK1.93760110
17PKN21.78670831
18MKNK21.77347488
19PLK41.74042309
20ADRBK21.67132115
21FLT31.63013438
22ZAK1.47226485
23BRSK21.43733797
24CASK1.41363513
25CAMK1G1.39718247
26TGFBR11.33716944
27ERBB31.33208285
28NLK1.23376433
29MAP4K21.20531920
30STK31.19181791
31WEE11.18729904
32EIF2AK31.15759413
33MELK1.12096783
34FGFR11.07667762
35MKNK11.07246902
36BRD41.07171629
37BCR1.03993391
38SIK30.99132089
39PAK30.98220839
40TTK0.93860694
41PDGFRA0.93325086
42NEK10.92987904
43TRPM70.89373499
44PLK20.87672746
45PLK30.85651411
46DAPK20.80789792
47EIF2AK10.79867963
48STK100.79683161
49MAPK130.79540776
50MAP2K70.78977995
51EIF2AK20.76046265
52TSSK60.75071967
53SGK20.68973313
54STK40.67807512
55DYRK30.66949450
56CDK30.66935222
57ADRBK10.64480108
58MUSK0.62105702
59PDGFRB0.61259109
60AURKB0.60158701
61STK38L0.58993024
62CSNK1G10.57982652
63ATM0.55400874
64MYLK0.55083303
65PRKCE0.55072765
66NME10.53781503
67PLK10.52999478
68ATR0.52369370
69FER0.51785244
70PIK3CG0.50278297
71TLK10.49110319
72CAMK1D0.47919865
73WNK40.47525402
74BUB10.45417960
75AKT20.44374122
76GRK10.43111243
77CHEK10.41411359
78CHEK20.40804259
79CAMK2D0.38780978
80PRKG10.38730598
81MINK10.37104262
82PRKAA20.36727114
83MAP2K60.36045527
84DMPK0.35815138
85VRK10.33303928
86NEK20.32341224
87RPS6KB10.31411331
88INSRR0.31349094
89MAPKAPK30.30367808
90CSNK1E0.27953661
91PRKACB0.26907069
92CHUK0.26090466
93SGK2230.25717673
94SGK4940.25717673
95WNK10.25684094
96STK390.22050982
97CDK10.21541285
98MAPK140.21427095
99NEK90.20890895
100MAP2K10.20712317

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81366982
2Selenocompound metabolism_Homo sapiens_hsa004502.48701056
3Protein export_Homo sapiens_hsa030602.44825223
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43064285
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.42769399
6Fanconi anemia pathway_Homo sapiens_hsa034602.37404105
7Propanoate metabolism_Homo sapiens_hsa006402.25842955
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22000296
9Homologous recombination_Homo sapiens_hsa034402.17881250
10Non-homologous end-joining_Homo sapiens_hsa034502.12078852
11TGF-beta signaling pathway_Homo sapiens_hsa043502.10064715
12Basal transcription factors_Homo sapiens_hsa030222.09440850
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89064507
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84828006
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83737927
16Proteasome_Homo sapiens_hsa030501.82229029
17Steroid biosynthesis_Homo sapiens_hsa001001.72691335
18Ovarian steroidogenesis_Homo sapiens_hsa049131.70825576
19Butanoate metabolism_Homo sapiens_hsa006501.68185454
20Olfactory transduction_Homo sapiens_hsa047401.65376222
21RNA degradation_Homo sapiens_hsa030181.56514474
22Nitrogen metabolism_Homo sapiens_hsa009101.54461056
23Circadian rhythm_Homo sapiens_hsa047101.49589836
24RNA transport_Homo sapiens_hsa030131.44782043
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42333223
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36696965
27Phototransduction_Homo sapiens_hsa047441.33165895
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31316052
29One carbon pool by folate_Homo sapiens_hsa006701.28919360
30Mismatch repair_Homo sapiens_hsa034301.28090459
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27364965
32Basal cell carcinoma_Homo sapiens_hsa052171.18746104
33Pyruvate metabolism_Homo sapiens_hsa006201.18423153
34Wnt signaling pathway_Homo sapiens_hsa043101.17128069
35Fatty acid metabolism_Homo sapiens_hsa012121.15575206
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.15475346
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07590554
38Hippo signaling pathway_Homo sapiens_hsa043901.04922795
39Retinol metabolism_Homo sapiens_hsa008301.04215251
40Fat digestion and absorption_Homo sapiens_hsa049751.03645561
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02344338
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01392481
43Cell cycle_Homo sapiens_hsa041101.01272440
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97776594
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97675523
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97255417
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.96001500
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95304976
49Fatty acid degradation_Homo sapiens_hsa000710.90826582
50Tryptophan metabolism_Homo sapiens_hsa003800.90763217
51Regulation of autophagy_Homo sapiens_hsa041400.89838419
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89069560
53N-Glycan biosynthesis_Homo sapiens_hsa005100.87079599
54Hedgehog signaling pathway_Homo sapiens_hsa043400.86524971
55Nucleotide excision repair_Homo sapiens_hsa034200.84210185
56Adherens junction_Homo sapiens_hsa045200.80248881
57Peroxisome_Homo sapiens_hsa041460.80075823
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79870618
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79371648
60mRNA surveillance pathway_Homo sapiens_hsa030150.77620080
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.75332977
62Mineral absorption_Homo sapiens_hsa049780.69944533
63Lysine degradation_Homo sapiens_hsa003100.69419799
64Inositol phosphate metabolism_Homo sapiens_hsa005620.68579055
65Oxidative phosphorylation_Homo sapiens_hsa001900.66329157
66Oocyte meiosis_Homo sapiens_hsa041140.66161396
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61652075
68Glutathione metabolism_Homo sapiens_hsa004800.61644936
69Linoleic acid metabolism_Homo sapiens_hsa005910.61297501
70Tight junction_Homo sapiens_hsa045300.58940924
71ABC transporters_Homo sapiens_hsa020100.58076319
72Vitamin digestion and absorption_Homo sapiens_hsa049770.56695059
73Chemical carcinogenesis_Homo sapiens_hsa052040.56645818
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.54616482
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54531111
76Melanogenesis_Homo sapiens_hsa049160.53995253
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53654678
78Purine metabolism_Homo sapiens_hsa002300.51340208
79Metabolic pathways_Homo sapiens_hsa011000.51083519
80PPAR signaling pathway_Homo sapiens_hsa033200.50866912
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50313341
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47796920
83RNA polymerase_Homo sapiens_hsa030200.46649524
84Ether lipid metabolism_Homo sapiens_hsa005650.46440241
85Fatty acid biosynthesis_Homo sapiens_hsa000610.46399489
86Taste transduction_Homo sapiens_hsa047420.45657341
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45442271
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44998741
89Nicotine addiction_Homo sapiens_hsa050330.41059259
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40311513
91Huntingtons disease_Homo sapiens_hsa050160.37849158
92Spliceosome_Homo sapiens_hsa030400.36536955
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35830432
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35537203
95Calcium signaling pathway_Homo sapiens_hsa040200.34293299
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34176744
97cAMP signaling pathway_Homo sapiens_hsa040240.33988999
98Glycerolipid metabolism_Homo sapiens_hsa005610.33132005
99Melanoma_Homo sapiens_hsa052180.32522991
100Small cell lung cancer_Homo sapiens_hsa052220.32316450

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