HSPBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.90006094
2axonemal dynein complex assembly (GO:0070286)5.61953728
3ribosomal small subunit assembly (GO:0000028)4.89951499
4proteasome assembly (GO:0043248)4.76873522
5motile cilium assembly (GO:0044458)4.69978296
6viral transcription (GO:0019083)4.59937477
7maturation of SSU-rRNA (GO:0030490)4.58207042
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.57787523
9formation of translation preinitiation complex (GO:0001731)4.55548229
10translational termination (GO:0006415)4.50922692
11ribosomal small subunit biogenesis (GO:0042274)4.46659493
12nucleobase biosynthetic process (GO:0046112)4.34628034
13DNA strand elongation involved in DNA replication (GO:0006271)4.34067792
14translational elongation (GO:0006414)4.30567446
15protein maturation by protein folding (GO:0022417)4.29145007
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.28481403
17purine nucleobase biosynthetic process (GO:0009113)4.20578643
18GTP biosynthetic process (GO:0006183)4.19492809
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.16928490
20ribosome biogenesis (GO:0042254)4.15955089
21termination of RNA polymerase III transcription (GO:0006386)4.12824226
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.12824226
23ribonucleoprotein complex biogenesis (GO:0022613)4.12232877
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.11907111
25DNA strand elongation (GO:0022616)4.10737924
26translational initiation (GO:0006413)4.08942024
27peptidyl-arginine N-methylation (GO:0035246)4.07409636
28peptidyl-arginine methylation (GO:0018216)4.07409636
29pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.07239703
30telomere maintenance via semi-conservative replication (GO:0032201)4.03862223
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.00785251
32pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.00347198
33regulation of mitochondrial translation (GO:0070129)3.99197955
34pseudouridine synthesis (GO:0001522)3.98778446
35ribosomal large subunit biogenesis (GO:0042273)3.96666971
36UTP metabolic process (GO:0046051)3.96483174
37DNA replication initiation (GO:0006270)3.95769014
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.94238552
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.93575494
40negative regulation of ligase activity (GO:0051352)3.93575494
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.93128695
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92962471
43pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.91051276
44GDP-mannose metabolic process (GO:0019673)3.87413301
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.84154477
46left/right pattern formation (GO:0060972)3.82767793
47spliceosomal snRNP assembly (GO:0000387)3.82488781
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.80566151
49proline biosynthetic process (GO:0006561)3.77699830
50protein insertion into membrane (GO:0051205)3.77226767
51mitotic nuclear envelope reassembly (GO:0007084)3.75746087
52nuclear envelope reassembly (GO:0031468)3.75746087
53cotranslational protein targeting to membrane (GO:0006613)3.75745125
54CTP biosynthetic process (GO:0006241)3.75271266
55CTP metabolic process (GO:0046036)3.75271266
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.74755322
57cellular protein complex disassembly (GO:0043624)3.73152121
58protein targeting to ER (GO:0045047)3.72831161
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.72801368
60regulation of cellular amino acid metabolic process (GO:0006521)3.71073510
61rRNA processing (GO:0006364)3.69785515
62guanosine-containing compound biosynthetic process (GO:1901070)3.65821914
632-deoxyribonucleotide biosynthetic process (GO:0009265)3.65678037
64deoxyribose phosphate biosynthetic process (GO:0046385)3.65678037
65rRNA modification (GO:0000154)3.64195056
66viral life cycle (GO:0019058)3.64175429
67pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.62971697
68pyrimidine nucleotide catabolic process (GO:0006244)3.61340555
69translation (GO:0006412)3.59642370
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59573685
71ATP synthesis coupled proton transport (GO:0015986)3.59573685
72protein localization to endoplasmic reticulum (GO:0070972)3.59358650
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58445366
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.58131608
75rRNA metabolic process (GO:0016072)3.55454806
76cellular component biogenesis (GO:0044085)3.55304760
77pentose metabolic process (GO:0019321)3.55143354
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55012043
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52752153
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51818182
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51818182
82establishment of protein localization to mitochondrion (GO:0072655)3.50587866
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49999978
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49999978
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49999978
86protein targeting to mitochondrion (GO:0006626)3.48289143
87DNA replication checkpoint (GO:0000076)3.46800045
88signal transduction involved in DNA damage checkpoint (GO:0072422)3.45401102
89signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45401102
90pentose-phosphate shunt (GO:0006098)3.44606244
91chaperone-mediated protein transport (GO:0072321)3.44590241
92cullin deneddylation (GO:0010388)3.41548166
93positive regulation of ligase activity (GO:0051351)3.41097103
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.40001850
95maturation of 5.8S rRNA (GO:0000460)3.38961551
96protein complex disassembly (GO:0043241)3.37707345
97regulation of mammary gland epithelial cell proliferation (GO:0033599)3.37071149
98protein deneddylation (GO:0000338)3.35004216
99peptidyl-arginine omega-N-methylation (GO:0035247)3.33307546
100telomere maintenance via recombination (GO:0000722)3.32705490
101iron-sulfur cluster assembly (GO:0016226)3.32479791
102metallo-sulfur cluster assembly (GO:0031163)3.32479791
103protein retention in ER lumen (GO:0006621)3.30189898
104macromolecular complex disassembly (GO:0032984)3.29298385
105base-excision repair, AP site formation (GO:0006285)3.27278829
106DNA unwinding involved in DNA replication (GO:0006268)3.25155414
107folic acid metabolic process (GO:0046655)3.24587747
1087-methylguanosine mRNA capping (GO:0006370)3.24155830
109ribosome assembly (GO:0042255)3.24075516
110oxidative phosphorylation (GO:0006119)3.21675216
111histone arginine methylation (GO:0034969)3.20970603
112protein localization to mitochondrion (GO:0070585)3.20602902
113nucleobase-containing small molecule interconversion (GO:0015949)3.20483743
114amyloid precursor protein catabolic process (GO:0042987)3.20372965
115regulation of ubiquitin-protein transferase activity (GO:0051438)3.19391977
116regulation of translational termination (GO:0006449)3.15280231
117RNA capping (GO:0036260)3.15125341
1187-methylguanosine RNA capping (GO:0009452)3.15125341
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13158951
120glucose catabolic process (GO:0006007)3.12871186
121L-methionine salvage (GO:0071267)3.11424443
122L-methionine biosynthetic process (GO:0071265)3.11424443
123amino acid salvage (GO:0043102)3.11424443
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09498878
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09498878
126regulation of ligase activity (GO:0051340)3.09257598
127UTP biosynthetic process (GO:0006228)3.07222860
128transcription-coupled nucleotide-excision repair (GO:0006283)3.07103859
129telomere maintenance via telomere lengthening (GO:0010833)3.05364895
130rRNA transcription (GO:0009303)3.03213638
131G1/S transition of mitotic cell cycle (GO:0000082)3.02871855
132cell cycle G1/S phase transition (GO:0044843)3.02871855
133NADPH regeneration (GO:0006740)3.01515903
134GMP metabolic process (GO:0046037)3.01071565
135positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.99068373
136pyrimidine nucleotide biosynthetic process (GO:0006221)2.96172195
137nucleoside diphosphate phosphorylation (GO:0006165)2.95341124
138cilium movement (GO:0003341)2.94556889
139ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94436261
140cilium or flagellum-dependent cell motility (GO:0001539)2.94362370
141establishment of integrated proviral latency (GO:0075713)2.94070186
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93987493
143deoxyribonucleotide catabolic process (GO:0009264)2.90810790
144purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89668427
145purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88088165
146nucleoside triphosphate biosynthetic process (GO:0009142)2.87643343
147COPI coating of Golgi vesicle (GO:0048205)2.85389465
148Golgi transport vesicle coating (GO:0048200)2.85389465
149ncRNA 3-end processing (GO:0043628)2.82480058
150protein complex biogenesis (GO:0070271)2.81962911
151respiratory electron transport chain (GO:0022904)2.81415058
152negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.80720643
153base-excision repair (GO:0006284)2.78266410
154electron transport chain (GO:0022900)2.77918667
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77102326
156establishment of viral latency (GO:0019043)2.76997103
157mitochondrial fusion (GO:0008053)2.74556393
158UV protection (GO:0009650)2.73401147
159deoxyribonucleotide biosynthetic process (GO:0009263)2.71495576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.78428765
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.61057675
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.41111529
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73033610
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.60077823
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45091135
7* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34220964
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.32434579
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.28728901
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.28599721
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25317223
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19674524
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00169419
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85543356
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82581839
16* XRN2_22483619_ChIP-Seq_HELA_Human2.66838045
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.65207297
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43201680
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33002912
20VDR_23849224_ChIP-Seq_CD4+_Human2.32697001
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.23281887
22* GABP_19822575_ChIP-Seq_HepG2_Human2.22382078
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19957289
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18939163
25LXR_22292898_ChIP-Seq_THP-1_Human2.17944209
26DCP1A_22483619_ChIP-Seq_HELA_Human2.14357185
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13108667
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12974442
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05032915
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04918345
31FOXP3_21729870_ChIP-Seq_TREG_Human2.03931913
32TTF2_22483619_ChIP-Seq_HELA_Human2.03189169
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91574260
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89502749
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79999827
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79572281
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76517187
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76329530
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.75838207
40CIITA_25753668_ChIP-Seq_RAJI_Human1.74163438
41P68_20966046_ChIP-Seq_HELA_Human1.73957973
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67462842
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67065246
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66960592
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63638361
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63512855
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61123896
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60147626
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.59924358
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59143589
51MYC_22102868_ChIP-Seq_BL_Human1.57691535
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57614055
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56367271
54RACK7_27058665_Chip-Seq_MCF-7_Human1.56182844
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.55214520
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53890306
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51429489
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50346327
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45514963
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.43831267
61KDM5A_27292631_Chip-Seq_BREAST_Human1.40733543
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39847597
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39022722
64* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37763861
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.36466495
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35836844
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35070745
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34412458
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32078038
70BCL6_27268052_Chip-Seq_Bcells_Human1.31542224
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29883938
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29392157
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29000644
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.28430012
75SMC4_20622854_ChIP-Seq_HELA_Human1.25988271
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24374548
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24101562
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22989634
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22794104
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.21816370
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21258279
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20639190
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.20204839
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19844782
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19495334
86BCOR_27268052_Chip-Seq_Bcells_Human1.19098264
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19032819
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18720298
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18013947
90VDR_21846776_ChIP-Seq_THP-1_Human1.17669812
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16175248
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15738377
93* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15711573
94PHF8_20622854_ChIP-Seq_HELA_Human1.15455681
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.15122026
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12578662
97CTCF_27219007_Chip-Seq_Bcells_Human1.12511965
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12096948
99CTCF_20526341_ChIP-Seq_ESCs_Human1.10368274
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10031320
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.09466610
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09011950
103* YY1_22570637_ChIP-Seq_MALME-3M_Human1.07930232
104RARA_24833708_ChIP-Seq_LIVER_Mouse1.07823053
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07431798
106CTCF_21964334_Chip-Seq_Bcells_Human1.07141831
107ELK1_19687146_ChIP-ChIP_HELA_Human1.06596617
108ZNF263_19887448_ChIP-Seq_K562_Human1.05443959
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05046386
110CREB1_26743006_Chip-Seq_LNCaP_Human1.04678447
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03883857
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.03838381
113* TET1_21451524_ChIP-Seq_MESCs_Mouse1.03606287
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03589278
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03450658
116TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03305922
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01184326
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00810272
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00500790
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00220824
121TFEB_21752829_ChIP-Seq_HELA_Human0.98437100
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98331345
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97852857
124MYC_18940864_ChIP-ChIP_HL60_Human0.93879165
125* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93558352
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93066989
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93034768
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90525980
129AR_21909140_ChIP-Seq_LNCAP_Human0.90376533
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89606449
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88679185
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.87257941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98681215
2MP0004957_abnormal_blastocyst_morpholog3.93552900
3MP0010030_abnormal_orbit_morphology3.76018830
4MP0003111_abnormal_nucleus_morphology3.67818839
5MP0000678_abnormal_parathyroid_gland3.38864468
6MP0010094_abnormal_chromosome_stability3.13008462
7MP0003077_abnormal_cell_cycle2.96422171
8MP0002249_abnormal_larynx_morphology2.90563561
9MP0002396_abnormal_hematopoietic_system2.60005437
10MP0002234_abnormal_pharynx_morphology2.58781377
11MP0008058_abnormal_DNA_repair2.58446524
12MP0008932_abnormal_embryonic_tissue2.40685427
13MP0004859_abnormal_synaptic_plasticity2.38198604
14MP0008057_abnormal_DNA_replication2.33605595
15MP0001529_abnormal_vocalization2.33335154
16MP0003123_paternal_imprinting2.28662649
17MP0005623_abnormal_meninges_morphology2.27815030
18MP0006036_abnormal_mitochondrial_physio2.12787461
19MP0000049_abnormal_middle_ear2.01443034
20MP0006035_abnormal_mitochondrial_morpho1.95354156
21MP0005499_abnormal_olfactory_system1.94696971
22MP0005394_taste/olfaction_phenotype1.94696971
23MP0008789_abnormal_olfactory_epithelium1.93991806
24MP0002132_abnormal_respiratory_system1.90691881
25MP0005451_abnormal_body_composition1.87919323
26MP0000681_abnormal_thyroid_gland1.86761224
27MP0001968_abnormal_touch/_nociception1.85016893
28MP0003786_premature_aging1.82752027
29MP0005501_abnormal_skin_physiology1.82204156
30MP0000537_abnormal_urethra_morphology1.81387890
31MP0001730_embryonic_growth_arrest1.81370252
32MP0000358_abnormal_cell_content/1.80535278
33MP0003880_abnormal_central_pattern1.74593588
34MP0008007_abnormal_cellular_replicative1.72373726
35MP0001346_abnormal_lacrimal_gland1.70046427
36MP0002877_abnormal_melanocyte_morpholog1.68151245
37MP0001905_abnormal_dopamine_level1.66409649
38MP0002822_catalepsy1.64329585
39MP0005423_abnormal_somatic_nervous1.62654048
40MP0006292_abnormal_olfactory_placode1.62350988
41MP0003718_maternal_effect1.53995052
42MP0000566_synostosis1.53323251
43MP0002736_abnormal_nociception_after1.53133381
44MP0001188_hyperpigmentation1.53013547
45MP0002733_abnormal_thermal_nociception1.51692504
46MP0006276_abnormal_autonomic_nervous1.49928408
47MP0009333_abnormal_splenocyte_physiolog1.49723480
48MP0000350_abnormal_cell_proliferation1.47794243
49MP0005397_hematopoietic_system_phenotyp1.47664035
50MP0001545_abnormal_hematopoietic_system1.47664035
51MP0003635_abnormal_synaptic_transmissio1.47132926
52MP0001849_ear_inflammation1.46989627
53MP0008877_abnormal_DNA_methylation1.45001687
54MP0002796_impaired_skin_barrier1.41299168
55MP0000490_abnormal_crypts_of1.39076602
56MP0001986_abnormal_taste_sensitivity1.39065691
57MP0000313_abnormal_cell_death1.37575240
58MP0002653_abnormal_ependyma_morphology1.37363438
59MP0008875_abnormal_xenobiotic_pharmacok1.36367460
60MP0004185_abnormal_adipocyte_glucose1.34584343
61MP0002080_prenatal_lethality1.34307646
62MP0000751_myopathy1.32965564
63MP0003656_abnormal_erythrocyte_physiolo1.32407723
64MP0004147_increased_porphyrin_level1.31725782
65MP0009379_abnormal_foot_pigmentation1.30766589
66MP0001697_abnormal_embryo_size1.30492108
67MP0004142_abnormal_muscle_tone1.28170758
68MP0005075_abnormal_melanosome_morpholog1.27212414
69MP0005330_cardiomyopathy1.25163550
70MP0004811_abnormal_neuron_physiology1.24525806
71MP0002735_abnormal_chemical_nociception1.22877525
72MP0001970_abnormal_pain_threshold1.22734626
73MP0002160_abnormal_reproductive_system1.22380362
74MP0003763_abnormal_thymus_physiology1.21995876
75MP0008872_abnormal_physiological_respon1.21714005
76MP0005058_abnormal_lysosome_morphology1.20652937
77MP0004233_abnormal_muscle_weight1.20031753
78MP0004270_analgesia1.16304888
79MP0000467_abnormal_esophagus_morphology1.15520767
80MP0003646_muscle_fatigue1.15139789
81MP0002751_abnormal_autonomic_nervous1.14326169
82MP0000762_abnormal_tongue_morphology1.12470109
83MP0004133_heterotaxia1.12363650
84MP0002063_abnormal_learning/memory/cond1.11513536
85MP0009745_abnormal_behavioral_response1.10612672
86MP0002064_seizures1.08556563
87MP0002019_abnormal_tumor_incidence1.07594424
88MP0003879_abnormal_hair_cell1.06915712
89MP0002734_abnormal_mechanical_nocicepti1.06322672
90MP0003329_amyloid_beta_deposits1.03835420
91MP0008260_abnormal_autophagy1.03391115
92MP0003186_abnormal_redox_activity1.02070797
93MP0004808_abnormal_hematopoietic_stem1.01972137
94MP0003806_abnormal_nucleotide_metabolis1.00202902
95MP0003122_maternal_imprinting0.99901634
96MP0003315_abnormal_perineum_morphology0.98973008
97MP0002272_abnormal_nervous_system0.98120912
98MP0001727_abnormal_embryo_implantation0.97307958
99MP0000749_muscle_degeneration0.97284799
100MP0003221_abnormal_cardiomyocyte_apopto0.95995301
101MP0001672_abnormal_embryogenesis/_devel0.93998673
102MP0005380_embryogenesis_phenotype0.93998673
103MP0000733_abnormal_muscle_development0.93756585
104MP0003866_abnormal_defecation0.92656652
105MP0002089_abnormal_postnatal_growth/wei0.92625695
106MP0000703_abnormal_thymus_morphology0.92537777
107MP0002398_abnormal_bone_marrow0.91831503
108MP0002722_abnormal_immune_system0.90955055
109MP0009278_abnormal_bone_marrow0.90625498
110MP0000747_muscle_weakness0.90445664
111MP0000462_abnormal_digestive_system0.89948106
112MP0005083_abnormal_biliary_tract0.88830223
113MP0000750_abnormal_muscle_regeneration0.88536501
114MP0010352_gastrointestinal_tract_polyps0.87467925
115MP0000689_abnormal_spleen_morphology0.86830389
116MP0009840_abnormal_foam_cell0.85205793
117MP0008770_decreased_survivor_rate0.84930626
118MP0000759_abnormal_skeletal_muscle0.84750851
119MP0003984_embryonic_growth_retardation0.84682164
120MP0009046_muscle_twitch0.83872704
121MP0005670_abnormal_white_adipose0.83656799
122MP0003705_abnormal_hypodermis_morpholog0.83555196
123MP0002184_abnormal_innervation0.82929729
124MP0003121_genomic_imprinting0.82622583
125MP0003942_abnormal_urinary_system0.81911445
126MP0002088_abnormal_embryonic_growth/wei0.81328109
127MP0003453_abnormal_keratinocyte_physiol0.81198389
128MP0003567_abnormal_fetal_cardiomyocyte0.81152991
129MP0002085_abnormal_embryonic_tissue0.81070053
130MP0002269_muscular_atrophy0.80326647
131MP0000003_abnormal_adipose_tissue0.79582285
132MP0001145_abnormal_male_reproductive0.78683451
133MP0001764_abnormal_homeostasis0.78663388
134MP0002572_abnormal_emotion/affect_behav0.78483004
135MP0002210_abnormal_sex_determination0.78338796
136MP0005386_behavior/neurological_phenoty0.77798975
137MP0004924_abnormal_behavior0.77798975
138MP0004858_abnormal_nervous_system0.76798964
139MP0001440_abnormal_grooming_behavior0.75552181
140MP0009053_abnormal_anal_canal0.75219715
141MP0002084_abnormal_developmental_patter0.73747143
142MP0005384_cellular_phenotype0.73695047
143MP0010771_integument_phenotype0.73515548
144MP0002429_abnormal_blood_cell0.73145139
145MP0010234_abnormal_vibrissa_follicle0.72811777
146MP0002177_abnormal_outer_ear0.70775181
147MP0000858_altered_metastatic_potential0.70275785
148MP0003861_abnormal_nervous_system0.68583114
149MP0009672_abnormal_birth_weight0.68226343
150MP0003075_altered_response_to0.66814070
151MP0002277_abnormal_respiratory_mucosa0.66439098
152MP0001270_distended_abdomen0.66154068
153MP0001661_extended_life_span0.64361691
154MP0003938_abnormal_ear_development0.62704673
155MP0005165_increased_susceptibility_to0.59921951
156MP0001881_abnormal_mammary_gland0.59807675
157MP0002098_abnormal_vibrissa_morphology0.57971835
158MP0000955_abnormal_spinal_cord0.57682357

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.36796975
2Abnormal respiratory motile cilium physiology (HP:0012261)5.41529305
3Abnormal respiratory motile cilium morphology (HP:0005938)5.36980824
4Abnormal respiratory epithelium morphology (HP:0012253)5.36980824
5Abnormality of cells of the erythroid lineage (HP:0012130)5.00638642
6Abnormal ciliary motility (HP:0012262)4.86816503
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.85194949
8Absent/shortened dynein arms (HP:0200106)4.85194949
9Abnormal number of erythroid precursors (HP:0012131)4.83887414
10Rhinitis (HP:0012384)4.53222140
11Cerebral hypomyelination (HP:0006808)4.50395558
12Chronic bronchitis (HP:0004469)4.22604400
13Hepatocellular necrosis (HP:0001404)4.13361410
14Nasal polyposis (HP:0100582)4.05570951
15Aplastic anemia (HP:0001915)4.01287773
16Decreased activity of mitochondrial respiratory chain (HP:0008972)4.00703384
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.00703384
18Mitochondrial inheritance (HP:0001427)3.70221341
19Acute necrotizing encephalopathy (HP:0006965)3.68122562
20Birth length less than 3rd percentile (HP:0003561)3.67650845
21Abnormal mitochondria in muscle tissue (HP:0008316)3.60152116
22Abnormality of the anterior horn cell (HP:0006802)3.51314449
23Degeneration of anterior horn cells (HP:0002398)3.51314449
24Hepatic necrosis (HP:0002605)3.42270492
25Increased CSF lactate (HP:0002490)3.42241804
26Broad distal phalanx of finger (HP:0009836)3.40496317
27Reticulocytopenia (HP:0001896)3.29876439
28Abnormality of the nasal mucosa (HP:0000433)3.24440310
29Delusions (HP:0000746)3.23295676
30Increased serum lactate (HP:0002151)3.23109056
31Macrocytic anemia (HP:0001972)3.19739496
32Oral leukoplakia (HP:0002745)3.16636656
33Emotional lability (HP:0000712)3.14155551
34Male infertility (HP:0003251)3.12368139
35Congenital malformation of the right heart (HP:0011723)3.09069026
36Double outlet right ventricle (HP:0001719)3.09069026
37Atrophy/Degeneration involving motor neurons (HP:0007373)3.05079390
38Truncus arteriosus (HP:0001660)3.01513778
39CNS hypomyelination (HP:0003429)2.95613173
40Bronchiectasis (HP:0002110)2.92190908
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90316485
42Microretrognathia (HP:0000308)2.85519993
43Carpal bone hypoplasia (HP:0001498)2.83772809
44Atelectasis (HP:0100750)2.82824068
45Pallor (HP:0000980)2.81393065
46Rough bone trabeculation (HP:0100670)2.80012019
47Acute encephalopathy (HP:0006846)2.79968246
48Lactic acidosis (HP:0003128)2.79739049
49Myokymia (HP:0002411)2.76319749
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.75768469
51Unsteady gait (HP:0002317)2.75020656
52Progressive macrocephaly (HP:0004481)2.73282016
53Breast hypoplasia (HP:0003187)2.73123843
54Increased hepatocellular lipid droplets (HP:0006565)2.69875008
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.69769690
56Poor suck (HP:0002033)2.63870786
57Progressive muscle weakness (HP:0003323)2.62922542
58Abnormality of glycolysis (HP:0004366)2.58697954
59Increased serum pyruvate (HP:0003542)2.58697954
60CNS demyelination (HP:0007305)2.55053958
61Increased intramyocellular lipid droplets (HP:0012240)2.53286686
62Distal upper limb amyotrophy (HP:0007149)2.52649987
63Upper limb amyotrophy (HP:0009129)2.52649987
643-Methylglutaconic aciduria (HP:0003535)2.52209895
65Stridor (HP:0010307)2.50466974
66Distal lower limb muscle weakness (HP:0009053)2.46032790
67Microvesicular hepatic steatosis (HP:0001414)2.45728909
68Colon cancer (HP:0003003)2.45390458
69Hand muscle atrophy (HP:0009130)2.44455238
70Respiratory failure (HP:0002878)2.42470733
71Exercise intolerance (HP:0003546)2.42294179
72Premature ovarian failure (HP:0008209)2.40067989
73Occipital encephalocele (HP:0002085)2.36551183
74Postnatal microcephaly (HP:0005484)2.35851171
75Myopathic facies (HP:0002058)2.34896661
76Hypoplastic left heart (HP:0004383)2.33370522
77Abnormality of the motor neurons (HP:0002450)2.30918690
78Abnormal neuron morphology (HP:0012757)2.30918690
79Pancytopenia (HP:0001876)2.30492223
80Hyperthyroidism (HP:0000836)2.30307812
81Hypokinesia (HP:0002375)2.29844151
82Absent thumb (HP:0009777)2.28201522
83Lipid accumulation in hepatocytes (HP:0006561)2.28141091
84Abnormal gallbladder physiology (HP:0012438)2.28014430
85Cholecystitis (HP:0001082)2.28014430
86Down-sloping shoulders (HP:0200021)2.24475370
87Abnormality of the umbilical cord (HP:0010881)2.22825090
88Visual hallucinations (HP:0002367)2.22194777
89Muscle fiber atrophy (HP:0100295)2.20789560
90Unilateral renal agenesis (HP:0000122)2.18571757
91Personality changes (HP:0000751)2.18429216
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18424409
93Abnormality of the distal phalanges of the toes (HP:0010182)2.17489186
94Abnormal ventriculo-arterial connection (HP:0011563)2.16299092
95Transposition of the great arteries (HP:0001669)2.16299092
96Abnormal connection of the cardiac segments (HP:0011545)2.16299092
97Testicular atrophy (HP:0000029)2.15950356
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15622636
99Abnormality of alanine metabolism (HP:0010916)2.15622636
100Hyperalaninemia (HP:0003348)2.15622636
101Multiple enchondromatosis (HP:0005701)2.12593468
102Amyotrophic lateral sclerosis (HP:0007354)2.10699447
103Infertility (HP:0000789)2.10625801
104Trismus (HP:0000211)2.10364750
105Self-mutilation (HP:0000742)2.09606261
106Secondary amenorrhea (HP:0000869)2.09488830
107Patellar aplasia (HP:0006443)2.09449155
108Short nail (HP:0001799)2.08907597
109Achilles tendon contracture (HP:0001771)2.08497820
110Abnormality of the fetal cardiovascular system (HP:0010948)2.07229930
111Abnormal umbilical cord blood vessels (HP:0011403)2.07229930
112Single umbilical artery (HP:0001195)2.07229930
113Ragged-red muscle fibers (HP:0003200)2.05356032
114Type I transferrin isoform profile (HP:0003642)2.04536963
115Aplasia/Hypoplasia of the patella (HP:0006498)2.04412110
116Increased muscle lipid content (HP:0009058)2.03451150
117Respiratory difficulties (HP:0002880)2.02100714
118Megaloblastic anemia (HP:0001889)2.00977295
119Sclerocornea (HP:0000647)2.00314722
120Type 2 muscle fiber atrophy (HP:0003554)1.98879580
121Recurrent otitis media (HP:0000403)1.98201690
122Exertional dyspnea (HP:0002875)1.98099263
123Death in infancy (HP:0001522)1.94974072
124Abnormality of the labia minora (HP:0012880)1.94952722
125Angiofibromas (HP:0010615)1.93254311
126Adenoma sebaceum (HP:0009720)1.93254311
127Renal Fanconi syndrome (HP:0001994)1.92628578
128Neoplasm of the peripheral nervous system (HP:0100007)1.90784385
129Limb dystonia (HP:0002451)1.90730276
130Diaphragmatic weakness (HP:0009113)1.90677813
131Horseshoe kidney (HP:0000085)1.90205785
132Neuroendocrine neoplasm (HP:0100634)1.89453133
133Hypoplasia of the pons (HP:0012110)1.87342423
134Tongue fasciculations (HP:0001308)1.87278483
135Hyperacusis (HP:0010780)1.86164951
136Hypertensive crisis (HP:0100735)1.84793124
137Leukodystrophy (HP:0002415)1.80979556
138Ependymoma (HP:0002888)1.80113758
139Abnormal trabecular bone morphology (HP:0100671)1.79605546
140Hypoplastic heart (HP:0001961)1.78727184
141Thrombocytosis (HP:0001894)1.76547640
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76167924
143Selective tooth agenesis (HP:0001592)1.75983371
144Insomnia (HP:0100785)1.75237349
145Abnormality of the aortic arch (HP:0012303)1.74775923
146Premature graying of hair (HP:0002216)1.73584679
147Focal motor seizures (HP:0011153)1.73509311
148Cholelithiasis (HP:0001081)1.72077011
149Cerebral edema (HP:0002181)1.71290947
150Abnormality of pain sensation (HP:0010832)1.70526535
151Impaired pain sensation (HP:0007328)1.70526535
152Abnormality of the Achilles tendon (HP:0005109)1.70375716
153Abnormal number of incisors (HP:0011064)1.69549840
154Muscle fibrillation (HP:0010546)1.68451545
155Ankle clonus (HP:0011448)1.67981510
156Basal cell carcinoma (HP:0002671)1.67819749
157Spinal cord compression (HP:0002176)1.66284053
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64258155
159Centrally nucleated skeletal muscle fibers (HP:0003687)1.63260674
160Redundant skin (HP:0001582)1.61874989
161Abnormality of reticulocytes (HP:0004312)1.60832461
162Muscle stiffness (HP:0003552)1.60188753
163Abnormality of the tricuspid valve (HP:0001702)1.59666512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.08325365
2BUB14.86050811
3SMG14.59658106
4WEE13.77499133
5STK163.52789944
6NME23.31255727
7TSSK62.81692418
8EIF2AK12.77416198
9TESK22.63833571
10TRIB32.49518185
11IRAK32.42319262
12CDK192.31024631
13PIM22.11987494
14CDC72.05999908
15ARAF2.05452512
16MAP3K121.96503504
17NEK11.92356879
18NME11.84863236
19MAPK151.83504870
20SCYL21.83315293
21MAP3K111.80936418
22BRSK11.72583348
23PRKD31.72110826
24DYRK31.67317162
25ICK1.65932163
26VRK11.65916495
27EIF2AK31.61992014
28CCNB11.60480101
29DAPK11.58926689
30BRAF1.48712415
31TAF11.46582543
32SRPK11.46404248
33ACVR1B1.45804974
34MINK11.41810170
35BRSK21.40864448
36NEK21.35353843
37TLK11.28048701
38AURKA1.24995324
39MAP3K91.21871914
40MARK11.15151190
41PLK41.12616266
42TESK11.11806656
43BCKDK1.10486172
44MAPKAPK51.06751571
45PLK11.05605827
46LMTK21.05235655
47CSNK1A1L1.04059541
48KDR1.01467298
49MAP4K10.99192210
50LIMK10.98601872
51PNCK0.98024186
52PASK0.97730930
53PAK40.93084294
54ILK0.91607936
55RPS6KB20.91104962
56DYRK20.88975070
57PRPF4B0.88333645
58MST1R0.86640840
59CSNK1G20.85357870
60ERN10.83604698
61PLK30.83139958
62MAP2K60.82504651
63SIK10.82389365
64LRRK20.81891974
65GRK60.78473542
66MAPKAPK30.78008604
67PRKCI0.77132303
68PAK10.75389037
69MAP2K30.75343282
70RAF10.75147092
71CDK70.74386433
72CDK80.73784135
73CAMK2G0.72850146
74DAPK30.72613966
75MAP2K20.72272083
76ATR0.71965821
77CAMKK20.70634604
78RPS6KA40.69379990
79ABL20.69178130
80CSNK1G10.68906438
81IRAK20.68443837
82AKT20.67843518
83TAOK10.67493662
84MATK0.64255775
85AURKB0.63777948
86CSNK2A20.63093056
87PBK0.62452996
88PDK30.62376414
89PDK40.62376414
90CDK90.62332381
91CDK180.60165695
92CDK140.60123391
93EPHA20.59788388
94MAP3K80.58850860
95CDK11A0.58396976
96CSNK1G30.58164820
97GRK50.57729612
98ZAP700.57685856
99CSNK2A10.56291993
100UHMK10.55982557
101TAOK20.55687637
102CDK150.55009611
103CHEK20.54218572
104STK100.53765470
105FLT30.53259273
106NTRK10.52782791
107EPHA40.52601137
108SIK30.52584274
109TTK0.52319381
110PAK60.51685670
111ALK0.47795140
112EPHB20.46633184
113CAMKK10.46148490
114NTRK30.45919742
115KSR10.45528615
116EEF2K0.43481870
117CAMK10.43428210
118TGFBR10.42833453
119LATS20.42271814
120PHKG20.41757184
121PHKG10.41757184
122PKN20.41513520
123CAMK2B0.40648463
124MAPK110.39861378
125PRKCG0.38917216
126MAP2K70.38838491
127MAP3K30.38554675
128CDK20.38218403
129SYK0.37589470
130CDK40.37497799
131ADRBK20.36836475
132KIT0.36729504
133CHEK10.36432077
134MAP3K100.35646221
135PTK20.34624737
136STK40.30896773
137TBK10.30773567
138RPS6KA50.30578426
139MAP3K10.29302655

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.73715384
2Ribosome_Homo sapiens_hsa030104.58922535
3DNA replication_Homo sapiens_hsa030304.46605309
4RNA polymerase_Homo sapiens_hsa030203.93843745
5Mismatch repair_Homo sapiens_hsa034303.33742041
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15644190
7Pyrimidine metabolism_Homo sapiens_hsa002402.92563219
8Spliceosome_Homo sapiens_hsa030402.88259442
9Parkinsons disease_Homo sapiens_hsa050122.66366307
10Oxidative phosphorylation_Homo sapiens_hsa001902.61975266
11RNA transport_Homo sapiens_hsa030132.56256800
12Base excision repair_Homo sapiens_hsa034102.53627736
13Nucleotide excision repair_Homo sapiens_hsa034202.34460394
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07320691
15Huntingtons disease_Homo sapiens_hsa050162.02140433
16Homologous recombination_Homo sapiens_hsa034401.90847364
17Phenylalanine metabolism_Homo sapiens_hsa003601.75116990
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73389419
19Purine metabolism_Homo sapiens_hsa002301.62956071
20Cell cycle_Homo sapiens_hsa041101.60179052
21Alzheimers disease_Homo sapiens_hsa050101.56575734
22Sulfur relay system_Homo sapiens_hsa041221.51425754
23RNA degradation_Homo sapiens_hsa030181.34555965
24Synaptic vesicle cycle_Homo sapiens_hsa047211.31629450
25Folate biosynthesis_Homo sapiens_hsa007901.28595248
26Fatty acid elongation_Homo sapiens_hsa000621.28419929
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.21445471
28One carbon pool by folate_Homo sapiens_hsa006701.21362735
29Vitamin B6 metabolism_Homo sapiens_hsa007501.21186216
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20822622
31Biosynthesis of amino acids_Homo sapiens_hsa012301.17239056
32Basal transcription factors_Homo sapiens_hsa030221.16446144
33Pentose phosphate pathway_Homo sapiens_hsa000301.14658772
34Tyrosine metabolism_Homo sapiens_hsa003501.14319204
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14043034
36Oocyte meiosis_Homo sapiens_hsa041141.12241205
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.09950649
38Arginine and proline metabolism_Homo sapiens_hsa003301.09180554
39Cardiac muscle contraction_Homo sapiens_hsa042601.08545294
40Epstein-Barr virus infection_Homo sapiens_hsa051691.07875054
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06398226
42mRNA surveillance pathway_Homo sapiens_hsa030151.06268241
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05671948
44Sulfur metabolism_Homo sapiens_hsa009200.96286931
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93045379
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88846973
47Fanconi anemia pathway_Homo sapiens_hsa034600.88734448
48Protein export_Homo sapiens_hsa030600.86431362
49Carbon metabolism_Homo sapiens_hsa012000.82678274
50Regulation of autophagy_Homo sapiens_hsa041400.78803116
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78184129
52p53 signaling pathway_Homo sapiens_hsa041150.77985738
53Notch signaling pathway_Homo sapiens_hsa043300.77591901
54Collecting duct acid secretion_Homo sapiens_hsa049660.75841849
55Fructose and mannose metabolism_Homo sapiens_hsa000510.73655909
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71944888
57Thyroid cancer_Homo sapiens_hsa052160.71387838
58* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71195613
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70061148
60N-Glycan biosynthesis_Homo sapiens_hsa005100.69845015
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.65686841
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63830482
63beta-Alanine metabolism_Homo sapiens_hsa004100.62537816
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61959235
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61836596
66Galactose metabolism_Homo sapiens_hsa000520.61023594
67Non-homologous end-joining_Homo sapiens_hsa034500.60586153
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57547855
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54696198
70Basal cell carcinoma_Homo sapiens_hsa052170.54006567
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53522614
72Prion diseases_Homo sapiens_hsa050200.51567093
73Vibrio cholerae infection_Homo sapiens_hsa051100.51479177
74Peroxisome_Homo sapiens_hsa041460.50709774
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48144560
76Metabolic pathways_Homo sapiens_hsa011000.48123511
77Alcoholism_Homo sapiens_hsa050340.45124968
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44358158
79Shigellosis_Homo sapiens_hsa051310.42213592
80Arginine biosynthesis_Homo sapiens_hsa002200.41784873
81Nicotine addiction_Homo sapiens_hsa050330.40435444
82Pyruvate metabolism_Homo sapiens_hsa006200.38833018
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38800923
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36243782
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35649148
86Amphetamine addiction_Homo sapiens_hsa050310.34889837
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34328749
88Antigen processing and presentation_Homo sapiens_hsa046120.34318175
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29416599
90Glutathione metabolism_Homo sapiens_hsa004800.29056304
91Olfactory transduction_Homo sapiens_hsa047400.28619999
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.28449043
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28345333
94Dopaminergic synapse_Homo sapiens_hsa047280.26683094
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26136010
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25492821
97Viral carcinogenesis_Homo sapiens_hsa052030.25355159
98Endocytosis_Homo sapiens_hsa041440.24611572
99Steroid biosynthesis_Homo sapiens_hsa001000.24408005
100Long-term potentiation_Homo sapiens_hsa047200.24228704
101Chronic myeloid leukemia_Homo sapiens_hsa052200.23835391
102HTLV-I infection_Homo sapiens_hsa051660.23126308
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.21865607
104Legionellosis_Homo sapiens_hsa051340.18948945
105Pancreatic cancer_Homo sapiens_hsa052120.18616555
106HIF-1 signaling pathway_Homo sapiens_hsa040660.18453792
107Selenocompound metabolism_Homo sapiens_hsa004500.17672418
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17630863
109Fatty acid metabolism_Homo sapiens_hsa012120.17421547
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17090713
111Salmonella infection_Homo sapiens_hsa051320.16952597
112Colorectal cancer_Homo sapiens_hsa052100.16767204
113Acute myeloid leukemia_Homo sapiens_hsa052210.14975823
114Hippo signaling pathway_Homo sapiens_hsa043900.12500711
115Systemic lupus erythematosus_Homo sapiens_hsa053220.11110695
116Bladder cancer_Homo sapiens_hsa052190.10910778
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10843035
118Herpes simplex infection_Homo sapiens_hsa051680.10408378
119Other glycan degradation_Homo sapiens_hsa005110.10375832
120Primary immunodeficiency_Homo sapiens_hsa053400.08730739
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08288362
122Non-small cell lung cancer_Homo sapiens_hsa052230.07353426
123Gap junction_Homo sapiens_hsa045400.07048528
124VEGF signaling pathway_Homo sapiens_hsa043700.06696569
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06367220
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.05688191
127Apoptosis_Homo sapiens_hsa042100.04859230
128Cocaine addiction_Homo sapiens_hsa050300.02867522

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