HSPB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)6.28666231
2regulation of relaxation of muscle (GO:1901077)6.24806949
3striated muscle contraction (GO:0006941)5.99289558
4response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.89261799
5regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.83500226
6cardiac muscle contraction (GO:0060048)5.73196124
7actin filament-based movement (GO:0030048)5.43095560
8regulation of actin filament-based movement (GO:1903115)5.26066857
9regulation of cell communication by electrical coupling (GO:0010649)5.20315988
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.01542293
11creatine metabolic process (GO:0006600)4.94565171
12actomyosin structure organization (GO:0031032)4.89020916
13regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.87867527
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.86121050
15L-phenylalanine metabolic process (GO:0006558)4.86121050
16L-phenylalanine catabolic process (GO:0006559)4.85579627
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.85579627
18regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.80759805
19cardiac muscle hypertrophy (GO:0003300)4.70294154
20response to inactivity (GO:0014854)4.67021083
21lysine catabolic process (GO:0006554)4.56817518
22lysine metabolic process (GO:0006553)4.56817518
23carnitine shuttle (GO:0006853)4.55433282
24fatty acid transmembrane transport (GO:1902001)4.52901306
25response to muscle activity (GO:0014850)4.52390990
26muscle contraction (GO:0006936)4.49371689
27actin-myosin filament sliding (GO:0033275)4.47472787
28muscle filament sliding (GO:0030049)4.47472787
29NADH metabolic process (GO:0006734)4.46699370
30striated muscle hypertrophy (GO:0014897)4.45369026
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45169379
32regulation of the force of heart contraction (GO:0002026)4.38485127
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.28446123
342-oxoglutarate metabolic process (GO:0006103)4.23988963
35sarcomere organization (GO:0045214)4.22457680
36kynurenine metabolic process (GO:0070189)4.20985336
37glyoxylate metabolic process (GO:0046487)4.15959316
38aromatic amino acid family catabolic process (GO:0009074)4.15589976
39plasma membrane repair (GO:0001778)4.13568366
40bundle of His cell to Purkinje myocyte communication (GO:0086069)4.10974639
41alpha-linolenic acid metabolic process (GO:0036109)4.08118729
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.07492415
43regulation of skeletal muscle contraction (GO:0014819)4.06814158
44muscle system process (GO:0003012)4.04232336
45regulation of triglyceride catabolic process (GO:0010896)3.98898587
46fatty acid beta-oxidation (GO:0006635)3.98237875
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.96685477
48negative regulation of fibrinolysis (GO:0051918)3.95138561
49regulation of protein activation cascade (GO:2000257)3.94557363
50skeletal muscle fiber development (GO:0048741)3.93984728
51muscle hypertrophy (GO:0014896)3.92734985
52cardiac muscle tissue morphogenesis (GO:0055008)3.90924642
53regulation of striated muscle contraction (GO:0006942)3.89821970
54positive regulation of fatty acid beta-oxidation (GO:0032000)3.88454743
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83626597
56sulfur amino acid catabolic process (GO:0000098)3.82759321
57amino-acid betaine metabolic process (GO:0006577)3.82374094
58muscle tissue morphogenesis (GO:0060415)3.82157226
59aspartate family amino acid catabolic process (GO:0009068)3.81444711
60bile acid biosynthetic process (GO:0006699)3.77220308
61acetyl-CoA metabolic process (GO:0006084)3.76453748
62complement activation, alternative pathway (GO:0006957)3.76452230
63actin-mediated cell contraction (GO:0070252)3.75693023
64cell communication involved in cardiac conduction (GO:0086065)3.75200379
65cellular ketone body metabolic process (GO:0046950)3.75189907
66regulation of complement activation (GO:0030449)3.74547774
67positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.71660045
68skeletal muscle adaptation (GO:0043501)3.71207415
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.70289278
70peptidyl-glutamic acid carboxylation (GO:0017187)3.69224742
71protein carboxylation (GO:0018214)3.69224742
72regulation of fibrinolysis (GO:0051917)3.69002137
73cardiac muscle cell development (GO:0055013)3.68963228
74high-density lipoprotein particle remodeling (GO:0034375)3.68523342
75fatty acid oxidation (GO:0019395)3.66865579
76striated muscle adaptation (GO:0014888)3.65909669
77tricarboxylic acid cycle (GO:0006099)3.64238696
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.63520370
79cell communication by electrical coupling (GO:0010644)3.62650623
80tryptophan catabolic process (GO:0006569)3.61509492
81indole-containing compound catabolic process (GO:0042436)3.61509492
82indolalkylamine catabolic process (GO:0046218)3.61509492
83lipid oxidation (GO:0034440)3.60581411
84fatty acid catabolic process (GO:0009062)3.59828087
85myotube cell development (GO:0014904)3.57422733
86adult heart development (GO:0007512)3.56441832
87regulation of sequestering of triglyceride (GO:0010889)3.56423935
88cardiac muscle hypertrophy in response to stress (GO:0014898)3.55447285
89muscle hypertrophy in response to stress (GO:0003299)3.55447285
90cardiac muscle adaptation (GO:0014887)3.55447285
91positive regulation of fatty acid oxidation (GO:0046321)3.54004446
92positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52416457
93cysteine metabolic process (GO:0006534)3.51972693
94carnitine metabolic process (GO:0009437)3.48871121
95carnitine transmembrane transport (GO:1902603)3.48829226
96urea metabolic process (GO:0019627)3.45748040
97urea cycle (GO:0000050)3.45748040
98regulation of calcium ion transmembrane transport (GO:1903169)3.44641995
99regulation of calcium ion transmembrane transporter activity (GO:1901019)3.44641995
100regulation of fatty acid oxidation (GO:0046320)3.44497338
101ethanol oxidation (GO:0006069)3.44283400
102cardiac cell development (GO:0055006)3.43369982
103serine family amino acid catabolic process (GO:0009071)3.41350785
104tryptophan metabolic process (GO:0006568)3.40272627
105monocarboxylic acid catabolic process (GO:0072329)3.39801893
106short-chain fatty acid metabolic process (GO:0046459)3.36840638
107acylglycerol homeostasis (GO:0055090)3.36270378
108triglyceride homeostasis (GO:0070328)3.36270378
109muscle cell cellular homeostasis (GO:0046716)3.36215013
110coenzyme catabolic process (GO:0009109)3.32990001
111homocysteine metabolic process (GO:0050667)3.32900938
112alpha-amino acid catabolic process (GO:1901606)3.32855004
113valine metabolic process (GO:0006573)3.31880955
114plasma lipoprotein particle clearance (GO:0034381)3.31548200
115muscle fiber development (GO:0048747)3.30924253
116positive regulation of lipid catabolic process (GO:0050996)3.30651046
117regulation of cardiac muscle cell contraction (GO:0086004)3.30604441
118dicarboxylic acid biosynthetic process (GO:0043650)3.29634977
119glycogen catabolic process (GO:0005980)3.29057983
120cardiac myofibril assembly (GO:0055003)3.28505276
121phospholipid efflux (GO:0033700)3.27440882
122negative regulation of fatty acid biosynthetic process (GO:0045717)3.27317976
123amino-acid betaine transport (GO:0015838)3.27301026
124carnitine transport (GO:0015879)3.27301026
125ventricular cardiac muscle cell action potential (GO:0086005)3.26880299
126glycogen biosynthetic process (GO:0005978)3.26201876
127glucan biosynthetic process (GO:0009250)3.26201876
128myofibril assembly (GO:0030239)3.24874834
129branched-chain amino acid catabolic process (GO:0009083)3.23036228
130regulation of cholesterol esterification (GO:0010872)3.22999445
131nitrogen cycle metabolic process (GO:0071941)3.21841873
132sodium ion export (GO:0071436)3.20781108
133ketone body metabolic process (GO:1902224)3.20509884
134negative regulation of protein activation cascade (GO:2000258)3.20090857
135ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.19631447
136regulation of fatty acid beta-oxidation (GO:0031998)3.19012554
137phospholipid homeostasis (GO:0055091)3.17712782
138reverse cholesterol transport (GO:0043691)3.17636174
139protein-lipid complex remodeling (GO:0034368)3.16804143
140macromolecular complex remodeling (GO:0034367)3.16804143
141plasma lipoprotein particle remodeling (GO:0034369)3.16804143
142regulation of membrane repolarization (GO:0060306)3.16663649
143relaxation of muscle (GO:0090075)3.16191082
144negative regulation of potassium ion transmembrane transport (GO:1901380)3.15947556
145skeletal muscle tissue development (GO:0007519)3.15693335
146relaxation of cardiac muscle (GO:0055119)3.15642986
147cellular amino acid catabolic process (GO:0009063)3.14434813
148sarcoplasmic reticulum calcium ion transport (GO:0070296)3.14300197
149bile acid metabolic process (GO:0008206)3.11251401
150fibrinolysis (GO:0042730)3.07343727
151organic acid catabolic process (GO:0016054)3.06036659
152carboxylic acid catabolic process (GO:0046395)3.06036659
153cellular modified amino acid catabolic process (GO:0042219)3.05599916
154oxaloacetate metabolic process (GO:0006107)3.05220027
155response to epinephrine (GO:0071871)3.04069081
156aromatic amino acid family metabolic process (GO:0009072)3.03931514
157glucan catabolic process (GO:0009251)3.02882045
158striated muscle atrophy (GO:0014891)3.00731254
159cellular glucuronidation (GO:0052695)3.00299282
160heart process (GO:0003015)3.00214904
161heart contraction (GO:0060047)3.00214904
162fatty acid homeostasis (GO:0055089)3.00092190
163tyrosine metabolic process (GO:0006570)2.99906758
164striated muscle cell development (GO:0055002)2.99592398
165regulation of heart rate (GO:0002027)2.97617478
166muscle adaptation (GO:0043500)2.97588930
167cellular response to epinephrine stimulus (GO:0071872)2.93900322
168negative regulation of calcium ion transmembrane transport (GO:1903170)2.93611272
169negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.93611272
170regulation of heart contraction (GO:0008016)2.92751922
171regulation of muscle system process (GO:0090257)2.91720111
172negative regulation of protein localization to cell surface (GO:2000009)2.89874370
173gluconeogenesis (GO:0006094)2.84113036
174regulation of muscle contraction (GO:0006937)2.83527778
175regulation of cardiac muscle contraction (GO:0055117)2.82867695
176regulation of ATPase activity (GO:0043462)2.81199563
177regulation of ATP catabolic process (GO:1903289)2.81199563
178cellular polysaccharide catabolic process (GO:0044247)2.80592830
179muscle structure development (GO:0061061)2.79580495
180cardiac muscle cell action potential (GO:0086001)2.79523098
181muscle organ development (GO:0007517)2.79372216
182regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78089555
183detection of calcium ion (GO:0005513)2.77078316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.39971223
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.45327637
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.76120287
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.15558201
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.60921532
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.86354925
7* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.63241781
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.41749930
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.35282718
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.04401661
11RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00201618
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.82852927
13CLOCK_20551151_ChIP-Seq_293T_Human2.47959304
14EZH2_22144423_ChIP-Seq_EOC_Human2.41875200
15ZNF263_19887448_ChIP-Seq_K562_Human2.34495431
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.14453852
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09123002
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.96301343
19* ESR2_21235772_ChIP-Seq_MCF-7_Human1.94959961
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.94258251
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.83385624
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83375158
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82477245
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.76980704
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.76980704
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72625704
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72095161
28* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69632589
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61411150
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59975695
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58470719
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58470719
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56729047
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53742663
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.51198544
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51062761
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.49956863
38* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45794114
39* ESR1_21235772_ChIP-Seq_MCF-7_Human1.43995575
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43370372
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42032326
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.40150241
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39829817
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39722663
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35680663
46* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35456653
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34721229
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34360419
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33828037
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33510571
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.30708305
52GATA1_22025678_ChIP-Seq_K562_Human1.30405496
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.28740057
54DROSHA_22980978_ChIP-Seq_HELA_Human1.25611636
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21802873
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20704263
57KDM2B_26808549_Chip-Seq_K562_Human1.19590249
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18954222
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.18549474
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17813800
61NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17483187
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13878207
63* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12460453
64AHR_22903824_ChIP-Seq_MCF-7_Human1.09164714
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08548819
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08091926
67* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06864825
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06756785
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.05574610
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05197075
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05164062
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04918742
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03867703
74* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03449433
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03382307
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03382307
77SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03244613
78* RACK7_27058665_Chip-Seq_MCF-7_Human1.03074761
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02396665
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02190202
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01453230
82CJUN_26792858_Chip-Seq_BT549_Human1.00936115
83ATF3_27146783_Chip-Seq_COLON_Human1.00537883
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98969981
85* TP53_20018659_ChIP-ChIP_R1E_Mouse0.98449259
86LXR_22292898_ChIP-Seq_THP-1_Human0.98445736
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98253725
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97618452
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97268725
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96241020
91NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96129090
92JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95714126
93* TET1_21490601_ChIP-Seq_MESCs_Mouse0.93854411
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93608272
95ISL1_27105846_Chip-Seq_CPCs_Mouse0.93013530
96* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91951936
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91825270
98HNF4A_19822575_ChIP-Seq_HepG2_Human0.91284025
99STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90440234
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.89882127
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89576640
102* TP53_23651856_ChIP-Seq_MEFs_Mouse0.89443111
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88362502
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88305362
105HTT_18923047_ChIP-ChIP_STHdh_Human0.88221929
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85984559
107* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85522196
108* CTCF_27219007_Chip-Seq_Bcells_Human0.83628475
109SMC4_20622854_ChIP-Seq_HELA_Human0.83587365
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.82687308
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82010012
112BCAT_22108803_ChIP-Seq_LS180_Human0.81325354
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80749950
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80742718
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79922077
116* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79858419
117SOX2_20726797_ChIP-Seq_SW620_Human0.79406944
118* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78695596
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77360133
120TP63_22573176_ChIP-Seq_HFKS_Human0.76574046
121GATA4_25053715_ChIP-Seq_YYC3_Human0.75012926
122* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74368689
123CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74009155
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73601036
125EGR1_19032775_ChIP-ChIP_M12_Human0.72712469
126GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72071693
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71857321
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.71004195
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.70928600
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69199423
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68441573
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67640616
133* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.66567922
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.66529252
135* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65564452
136* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64356725
137* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.64007317
138* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.64007317
139* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63440250
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62716742
141* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62353980
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.62226786
143* RUNX1_27514584_Chip-Seq_MCF-7_Human0.62075170
144CEBPB_22108803_ChIP-Seq_LS180_Human0.61803721
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.61798103
146TP63_23658742_ChIP-Seq_EP156T_Human0.61437245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.63591780
2MP0002837_dystrophic_cardiac_calcinosis4.41420050
3MP0005360_urolithiasis4.09501713
4MP0005085_abnormal_gallbladder_physiolo3.97078386
5MP0005365_abnormal_bile_salt3.56956442
6MP0000751_myopathy3.30983810
7MP0003806_abnormal_nucleotide_metabolis3.26193930
8MP0003646_muscle_fatigue3.24003861
9MP0000749_muscle_degeneration3.09979651
10MP0004084_abnormal_cardiac_muscle2.85275679
11MP0008875_abnormal_xenobiotic_pharmacok2.84317730
12MP0004036_abnormal_muscle_relaxation2.58998473
13MP0005330_cardiomyopathy2.43267902
14MP0004130_abnormal_muscle_cell2.42404319
15MP0005083_abnormal_biliary_tract2.33377526
16MP0003252_abnormal_bile_duct2.26801818
17MP0003705_abnormal_hypodermis_morpholog2.25926348
18MP0004510_myositis2.23932987
19MP0004087_abnormal_muscle_fiber2.21673380
20MP0010329_abnormal_lipoprotein_level2.21661971
21MP0004215_abnormal_myocardial_fiber2.21448498
22MP0009840_abnormal_foam_cell2.14427017
23MP0000750_abnormal_muscle_regeneration2.05878971
24MP0002269_muscular_atrophy1.99973060
25MP0000747_muscle_weakness1.93912419
26MP0009780_abnormal_chondrocyte_physiolo1.90366718
27MP0005275_abnormal_skin_tensile1.87941917
28MP0004145_abnormal_muscle_electrophysio1.86144988
29MP0005620_abnormal_muscle_contractility1.83917756
30MP0004270_analgesia1.81237948
31MP0005332_abnormal_amino_acid1.79477084
32MP0002972_abnormal_cardiac_muscle1.75888437
33MP0003195_calcinosis1.75472485
34MP0005670_abnormal_white_adipose1.70271436
35MP0002106_abnormal_muscle_physiology1.70243455
36MP0000759_abnormal_skeletal_muscle1.67160164
37MP0003191_abnormal_cellular_cholesterol1.65113406
38MP0008775_abnormal_heart_ventricle1.59690891
39MP0005666_abnormal_adipose_tissue1.58510125
40MP0002118_abnormal_lipid_homeostasis1.53398322
41MP0006036_abnormal_mitochondrial_physio1.52055209
42MP0010630_abnormal_cardiac_muscle1.47602708
43MP0005369_muscle_phenotype1.46753431
44MP0005385_cardiovascular_system_phenoty1.44230922
45MP0001544_abnormal_cardiovascular_syste1.44230922
46MP0005319_abnormal_enzyme/_coenzyme1.42210244
47MP0001666_abnormal_nutrient_absorption1.40483208
48MP0002796_impaired_skin_barrier1.38260118
49MP0008438_abnormal_cutaneous_collagen1.37532530
50MP0004185_abnormal_adipocyte_glucose1.33768372
51MP0000609_abnormal_liver_physiology1.33390508
52MP0006138_congestive_heart_failure1.32165688
53MP0003137_abnormal_impulse_conducting1.25478333
54MP0000013_abnormal_adipose_tissue1.25072515
55MP0010368_abnormal_lymphatic_system1.22049785
56MP0002971_abnormal_brown_adipose1.19535856
57MP0002254_reproductive_system_inflammat1.17279787
58MP0004484_altered_response_of1.14556066
59MP0002332_abnormal_exercise_endurance1.11622207
60MP0005375_adipose_tissue_phenotype1.11142925
61MP0003221_abnormal_cardiomyocyte_apopto1.08295486
62MP0002108_abnormal_muscle_morphology1.08099477
63MP0005451_abnormal_body_composition1.07971679
64MP0005423_abnormal_somatic_nervous1.07344112
65MP0005584_abnormal_enzyme/coenzyme_acti1.05399429
66MP0003941_abnormal_skin_development1.00358812
67MP0003566_abnormal_cell_adhesion0.97242695
68MP0003950_abnormal_plasma_membrane0.95859096
69MP0004233_abnormal_muscle_weight0.95398916
70MP0003279_aneurysm0.94656795
71MP0003879_abnormal_hair_cell0.94246880
72MP0004085_abnormal_heartbeat0.93308292
73MP0000579_abnormal_nail_morphology0.92693333
74MP0002060_abnormal_skin_morphology0.90971824
75MP0005266_abnormal_metabolism0.90487327
76MP0003186_abnormal_redox_activity0.87648922
77MP0008569_lethality_at_weaning0.85711849
78MP0009643_abnormal_urine_homeostasis0.84535784
79MP0004019_abnormal_vitamin_homeostasis0.84265724
80MP0006035_abnormal_mitochondrial_morpho0.82087633
81MP0005165_increased_susceptibility_to0.81558484
82MP0004859_abnormal_synaptic_plasticity0.81370539
83MP0002127_abnormal_cardiovascular_syste0.80293367
84MP0009384_cardiac_valve_regurgitation0.79721758
85MP0002078_abnormal_glucose_homeostasis0.79559620
86MP0003656_abnormal_erythrocyte_physiolo0.78985824
87MP0003828_pulmonary_edema0.75454746
88MP0000733_abnormal_muscle_development0.72281121
89MP0005334_abnormal_fat_pad0.71791753
90MP0000003_abnormal_adipose_tissue0.71760642
91MP0002138_abnormal_hepatobiliary_system0.70803700
92MP0001661_extended_life_span0.70697571
93MP0003011_delayed_dark_adaptation0.70184886
94MP0000230_abnormal_systemic_arterial0.69870412
95MP0000762_abnormal_tongue_morphology0.69655693
96MP0003868_abnormal_feces_composition0.69337747
97MP0001958_emphysema0.67518961
98MP0000343_altered_response_to0.65050295
99MP0009697_abnormal_copulation0.62235810
100MP0001299_abnormal_eye_distance/0.61656839
101MP0005501_abnormal_skin_physiology0.61199210
102MP0002734_abnormal_mechanical_nocicepti0.59678150
103MP0001764_abnormal_homeostasis0.59379381
104MP0000598_abnormal_liver_morphology0.58174114
105MP0005376_homeostasis/metabolism_phenot0.58046956
106MP0005023_abnormal_wound_healing0.57220859
107MP0004272_abnormal_basement_membrane0.56339230
108MP0002128_abnormal_blood_circulation0.55842670
109MP0010234_abnormal_vibrissa_follicle0.55511141
110MP0005535_abnormal_body_temperature0.54511306
111MP0002896_abnormal_bone_mineralization0.53803159
112MP0000427_abnormal_hair_cycle0.53603526
113MP0005167_abnormal_blood-brain_barrier0.53561065
114MP0005647_abnormal_sex_gland0.53548504
115MP0000266_abnormal_heart_morphology0.53151830
116MP0003045_fibrosis0.52623194
117MP0009672_abnormal_birth_weight0.48829509
118MP0010030_abnormal_orbit_morphology0.48314835
119MP0003690_abnormal_glial_cell0.47042381
120MP0005409_darkened_coat_color0.46510540
121MP0005503_abnormal_tendon_morphology0.46314375
122MP0005595_abnormal_vascular_smooth0.45249460
123MP0000767_abnormal_smooth_muscle0.44049905
124MP0003329_amyloid_beta_deposits0.42819891
125MP0000462_abnormal_digestive_system0.42403037
126MP0003635_abnormal_synaptic_transmissio0.42052633
127MP0000467_abnormal_esophagus_morphology0.41824125
128MP0001502_abnormal_circadian_rhythm0.41697924
129MP0002064_seizures0.39306460
130MP0001440_abnormal_grooming_behavior0.38628891
131MP0001346_abnormal_lacrimal_gland0.38520313
132MP0008874_decreased_physiological_sensi0.36784524
133MP0009115_abnormal_fat_cell0.36733376
134MP0002066_abnormal_motor_capabilities/c0.36322956
135MP0001486_abnormal_startle_reflex0.35905466
136MP0004381_abnormal_hair_follicle0.35313752

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.85036682
2Exercise-induced muscle cramps (HP:0003710)4.49888641
3Sudden death (HP:0001699)4.32891354
4Myoglobinuria (HP:0002913)4.29977100
5Right ventricular cardiomyopathy (HP:0011663)4.19831824
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.19528158
7* Hyporeflexia of lower limbs (HP:0002600)4.17636204
8Muscle fiber splitting (HP:0003555)4.14391416
9Muscle fiber inclusion bodies (HP:0100299)4.09380522
10Calf muscle hypertrophy (HP:0008981)4.09168784
11Deep venous thrombosis (HP:0002625)4.08129167
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.05062753
13Xanthomatosis (HP:0000991)3.93423518
14Muscle hypertrophy of the lower extremities (HP:0008968)3.88038113
15Increased connective tissue (HP:0009025)3.84829093
16Intrahepatic cholestasis (HP:0001406)3.83197661
17Ventricular tachycardia (HP:0004756)3.80295923
18* Distal lower limb muscle weakness (HP:0009053)3.69987822
19Hypoglycemic coma (HP:0001325)3.69948926
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69016902
21Type 1 muscle fiber predominance (HP:0003803)3.65878123
22Nemaline bodies (HP:0003798)3.60426001
23Hypoalphalipoproteinemia (HP:0003233)3.57277183
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.48785893
25Rhabdomyolysis (HP:0003201)3.40898302
26Hyperammonemia (HP:0001987)3.40561775
27Ketosis (HP:0001946)3.38971401
28Abnormality of the calf musculature (HP:0001430)3.38421049
29Distal arthrogryposis (HP:0005684)3.38089422
30Rimmed vacuoles (HP:0003805)3.34316931
31EMG: myopathic abnormalities (HP:0003458)3.33943827
32Hyperlipoproteinemia (HP:0010980)3.28624189
33Mildly elevated creatine phosphokinase (HP:0008180)3.22625381
34Difficulty running (HP:0009046)3.21526673
35Hypolipoproteinemia (HP:0010981)3.19601252
36Ketoacidosis (HP:0001993)3.17815506
37Hypobetalipoproteinemia (HP:0003563)3.08964295
38Abnormality of fatty-acid metabolism (HP:0004359)3.08213450
39Complement deficiency (HP:0004431)3.04426756
40Distal lower limb amyotrophy (HP:0008944)3.02315471
41Calcaneovalgus deformity (HP:0001848)2.99231064
42Frequent falls (HP:0002359)2.95724630
43Hyperglycinuria (HP:0003108)2.94475441
44* EMG: neuropathic changes (HP:0003445)2.90775681
45Prolonged partial thromboplastin time (HP:0003645)2.87904755
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.87182540
47Lipoatrophy (HP:0100578)2.86099339
48Palpitations (HP:0001962)2.85593936
49Myotonia (HP:0002486)2.84960506
50Round ear (HP:0100830)2.84324345
51Muscle stiffness (HP:0003552)2.81710238
52Asymmetric septal hypertrophy (HP:0001670)2.77847203
53Abnormality of serine family amino acid metabolism (HP:0010894)2.75942327
54Abnormality of glycine metabolism (HP:0010895)2.75942327
55Scapular winging (HP:0003691)2.75247066
56Abnormality of the foot musculature (HP:0001436)2.74471371
57Hyperglycinemia (HP:0002154)2.69775153
58* Areflexia of lower limbs (HP:0002522)2.66836654
59Difficulty climbing stairs (HP:0003551)2.65512439
60Bulbar palsy (HP:0001283)2.62966524
61Atrial fibrillation (HP:0005110)2.62566616
62Foot dorsiflexor weakness (HP:0009027)2.62187864
63Generalized muscle weakness (HP:0003324)2.62028291
64Deformed tarsal bones (HP:0008119)2.61817639
65Epidermoid cyst (HP:0200040)2.61560894
66Dicarboxylic aciduria (HP:0003215)2.61460056
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61460056
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58769051
69Atrioventricular block (HP:0001678)2.55468792
70Dilated cardiomyopathy (HP:0001644)2.52139217
71Spinal rigidity (HP:0003306)2.47660010
72Gowers sign (HP:0003391)2.47525684
73Lower limb amyotrophy (HP:0007210)2.44283027
74Primary atrial arrhythmia (HP:0001692)2.43357044
75Cerebral edema (HP:0002181)2.42483014
76Cholelithiasis (HP:0001081)2.38451225
77Increased variability in muscle fiber diameter (HP:0003557)2.35966187
78Abnormal atrioventricular conduction (HP:0005150)2.34702189
79Skin nodule (HP:0200036)2.32562944
80Supraventricular tachycardia (HP:0004755)2.31605962
81Heart block (HP:0012722)2.31510916
82Abnormality of the common coagulation pathway (HP:0010990)2.31117793
83Abnormality of skeletal muscle fiber size (HP:0012084)2.31091370
84Fetal akinesia sequence (HP:0001989)2.30335501
85Subaortic stenosis (HP:0001682)2.30076321
86Abnormality of the left ventricular outflow tract (HP:0011103)2.30076321
87Myopathic facies (HP:0002058)2.29900531
88Supraventricular arrhythmia (HP:0005115)2.27837048
89Abnormal gallbladder morphology (HP:0012437)2.26691674
90Bundle branch block (HP:0011710)2.26191263
91Syncope (HP:0001279)2.26063956
92Ventricular arrhythmia (HP:0004308)2.25026660
93Abnormality of complement system (HP:0005339)2.24796779
94Absent phalangeal crease (HP:0006109)2.24638142
95Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20527945
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20364000
97Abnormality of methionine metabolism (HP:0010901)2.20002961
98Weak cry (HP:0001612)2.18834176
99Hyperinsulinemic hypoglycemia (HP:0000825)2.17721238
100Abnormal finger flexion creases (HP:0006143)2.17432470
101Metabolic acidosis (HP:0001942)2.13926447
102Hyperglycemia (HP:0003074)2.11405620
103Ragged-red muscle fibers (HP:0003200)2.10970277
104Muscular dystrophy (HP:0003560)2.09722111
105Ulnar deviation of the wrist (HP:0003049)2.09204433
106Abnormality of sulfur amino acid metabolism (HP:0004339)2.09091302
107Late onset (HP:0003584)2.07586969
108Ventricular fibrillation (HP:0001663)2.07132493
109Lethargy (HP:0001254)2.05023955
110Abnormality of the intrinsic pathway (HP:0010989)2.03697877
111Abnormality of the Achilles tendon (HP:0005109)2.03341525
112Abnormality of the shoulder girdle musculature (HP:0001435)2.02150861
113Abnormality of serum amino acid levels (HP:0003112)2.01667201
114Neck muscle weakness (HP:0000467)2.00768864
115Proximal amyotrophy (HP:0007126)1.98810991
116Facial diplegia (HP:0001349)1.98083314
117Malignant hyperthermia (HP:0002047)1.97532437
118Hip contracture (HP:0003273)1.97249816
119Conjunctival hamartoma (HP:0100780)1.96531282
120Progressive muscle weakness (HP:0003323)1.95893929
121Hepatic necrosis (HP:0002605)1.94622512
122Limb-girdle muscle atrophy (HP:0003797)1.92752628
123Fatigable weakness (HP:0003473)1.92498059
124Abnormality of the neuromuscular junction (HP:0003398)1.92498059
125Slender build (HP:0001533)1.92312839
126Neonatal onset (HP:0003623)1.91522032
127Hypercholesterolemia (HP:0003124)1.89401246
128Gout (HP:0001997)1.88534426
129Joint hemorrhage (HP:0005261)1.88041331
130Fat malabsorption (HP:0002630)1.87273533
131Respiratory insufficiency due to muscle weakness (HP:0002747)1.86939056
132Testicular atrophy (HP:0000029)1.86824122
133Waddling gait (HP:0002515)1.82047980
134Popliteal pterygium (HP:0009756)1.81242041
135Hyperkalemia (HP:0002153)1.79287041
136Steppage gait (HP:0003376)1.75687189
137Aplasia of the musculature (HP:0100854)1.71128256
138Prolonged QT interval (HP:0001657)1.70301709
139Palmoplantar keratoderma (HP:0000982)1.66903396
140Left ventricular hypertrophy (HP:0001712)1.61988929
141Abnormality of the calcaneus (HP:0008364)1.61372730
142Abnormal EKG (HP:0003115)1.60892421
143Generalized amyotrophy (HP:0003700)1.59251495
144Limb-girdle muscle weakness (HP:0003325)1.59055645
145Sudden cardiac death (HP:0001645)1.58085657
146Hypoplastic heart (HP:0001961)1.57474949
147Metatarsus adductus (HP:0001840)1.54473724
148Limited hip movement (HP:0008800)1.49740404
149Rapidly progressive (HP:0003678)1.43220753
150Easy fatigability (HP:0003388)1.42409850
151Diaphragmatic weakness (HP:0009113)1.40794617
152Infantile muscular hypotonia (HP:0008947)1.37774371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.58615291
2OBSCN4.11080154
3BCKDK3.99361186
4TRIB33.68902844
5PHKG13.15981193
6PHKG23.15981193
7LMTK22.54320308
8PDK32.50573616
9PDK42.50573616
10PKN22.37654758
11ERN12.36331163
12MAPKAPK32.14884138
13SIK12.14581364
14PIK3CG2.09807759
15MYLK2.03184500
16PINK11.98575167
17FGFR41.85829630
18NEK11.82768356
19MAP2K31.68098628
20MAP3K31.66444408
21MUSK1.64458420
22PDK21.59241421
23PIK3CA1.58683999
24LATS21.53140729
25EPHA21.53099894
26MARK11.48692795
27DMPK1.46106568
28NEK91.36140411
29MAP3K71.26306167
30INSRR1.25041522
31MAP2K41.20344774
32RIPK11.19748891
33LATS11.19276352
34MAPK121.09991856
35EPHA31.09395417
36FER1.08305200
37TESK11.08069321
38EPHB11.08017552
39MST1R1.07903249
40FLT31.06050789
41TIE11.05979636
42STK38L1.04509001
43CAMK2B1.03908506
44PAK31.00147377
45PDGFRA0.97253771
46PTK60.93126702
47STK240.90778687
48CAMK10.89237500
49EPHB20.88720467
50PRKD10.85735414
51PRKAA20.85462032
52EEF2K0.85040002
53TRPM70.82703808
54ROCK10.79722498
55PAK60.79659445
56MAP3K120.78868279
57ERBB40.78327732
58LIMK10.76962958
59CAMK40.76667791
60ILK0.76627939
61GRK70.75037253
62CAMK2G0.74755211
63ROCK20.74334394
64MAP3K110.74236342
65CAMK2A0.73448088
66PRKAA10.73397409
67MAPK110.72070833
68CAMK2D0.68967238
69MAP3K50.68645342
70NTRK10.65525768
71MAP2K60.64928202
72ICK0.64633025
73PKN10.64166699
74TGFBR20.63814276
75MET0.63281519
76SGK30.63090086
77NME10.61159771
78MAPK70.60394838
79MAP3K90.60136125
80RET0.60098341
81KDR0.59293236
82ARAF0.57735189
83LRRK20.56653230
84MAP3K10.54876485
85NEK60.54718234
86EPHA40.54291282
87MOS0.53340136
88PTK20.53315364
89PRPF4B0.51966252
90KSR20.50888408
91MAP3K60.49523792
92NTRK30.49240465
93PRKACG0.48533873
94PRKD30.48411985
95MAP3K20.46855420
96SGK20.46772157
97ABL20.44984112
98MTOR0.43593077
99DAPK20.42615188
100SCYL20.42552533
101PDPK10.42135614
102AKT20.42124064
103MARK20.41867350
104MAPK100.41197119
105FGFR30.41071169
106PRKG10.40755698
107UHMK10.40001331
108RPS6KA20.39473429
109MAPK40.39332490
110SGK2230.38745858
111SGK4940.38745858
112JAK20.38529082
113MAP3K130.38101572
114STK380.37037484
115TAOK10.36763301
116RPS6KL10.36739065
117RPS6KC10.36739065
118JAK10.36723747
119* MAP2K10.36505691
120DAPK30.36498716
121AKT30.36177287
122TAOK20.35881039
123FGFR20.33822614
124RPS6KA30.32308566
125PRKACB0.32172974
126RPS6KB20.32116583
127ZAK0.32062349
128CDC42BPA0.31998892
129ERBB30.31833215
130GRK50.30951041
131ERBB20.30940769
132DYRK1B0.30838296
133RPS6KA60.30450048
134DDR20.30049181
135GSK3A0.29942221
136PRKG20.29808820
137PAK20.29466298
138FRK0.29041140
139FGFR10.27405952
140* PRKACA0.27278299
141MAP2K20.27173009
142CAMK1D0.26338865

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.79225684
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.25878379
3Fatty acid degradation_Homo sapiens_hsa000713.12975913
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91541137
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83031802
6Propanoate metabolism_Homo sapiens_hsa006402.82082118
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.80223880
8Nitrogen metabolism_Homo sapiens_hsa009102.75038353
9Arginine biosynthesis_Homo sapiens_hsa002202.68263342
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56503464
11Tryptophan metabolism_Homo sapiens_hsa003802.37743735
12Fatty acid metabolism_Homo sapiens_hsa012122.35881943
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21518999
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09629082
15Complement and coagulation cascades_Homo sapiens_hsa046102.05955626
16PPAR signaling pathway_Homo sapiens_hsa033202.05350122
17Butanoate metabolism_Homo sapiens_hsa006502.03501263
18Carbon metabolism_Homo sapiens_hsa012001.89209706
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79687602
20Pyruvate metabolism_Homo sapiens_hsa006201.79665795
21Peroxisome_Homo sapiens_hsa041461.76096128
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64542057
23Phenylalanine metabolism_Homo sapiens_hsa003601.61956677
24Starch and sucrose metabolism_Homo sapiens_hsa005001.59720868
25beta-Alanine metabolism_Homo sapiens_hsa004101.54319770
26Fatty acid elongation_Homo sapiens_hsa000621.52112082
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.51316421
28Chemical carcinogenesis_Homo sapiens_hsa052041.49324236
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49177423
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48238539
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48032932
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47049487
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46484220
34Oxytocin signaling pathway_Homo sapiens_hsa049211.46406822
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45399493
36Caffeine metabolism_Homo sapiens_hsa002321.44098868
37Tyrosine metabolism_Homo sapiens_hsa003501.40907544
38Biosynthesis of amino acids_Homo sapiens_hsa012301.38811239
39Calcium signaling pathway_Homo sapiens_hsa040201.38650171
40Gastric acid secretion_Homo sapiens_hsa049711.38534446
41Histidine metabolism_Homo sapiens_hsa003401.26025083
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23823782
43Renin secretion_Homo sapiens_hsa049241.22385687
44Cardiac muscle contraction_Homo sapiens_hsa042601.19594599
45Bile secretion_Homo sapiens_hsa049761.19524717
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16142918
47Dilated cardiomyopathy_Homo sapiens_hsa054141.14104160
48Long-term potentiation_Homo sapiens_hsa047201.13609575
49Retinol metabolism_Homo sapiens_hsa008301.10584361
50Fat digestion and absorption_Homo sapiens_hsa049751.09046105
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.06882803
52Arginine and proline metabolism_Homo sapiens_hsa003301.06137510
53Insulin secretion_Homo sapiens_hsa049111.05173242
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01607857
55Sulfur metabolism_Homo sapiens_hsa009201.00630971
56Circadian entrainment_Homo sapiens_hsa047130.98708363
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98611328
58GnRH signaling pathway_Homo sapiens_hsa049120.97444116
59Staphylococcus aureus infection_Homo sapiens_hsa051500.97165219
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.95990236
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95095057
62Selenocompound metabolism_Homo sapiens_hsa004500.94544412
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.93221397
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92041426
65Fatty acid biosynthesis_Homo sapiens_hsa000610.91120643
66ABC transporters_Homo sapiens_hsa020100.88546071
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84644447
68Amphetamine addiction_Homo sapiens_hsa050310.84390377
69cAMP signaling pathway_Homo sapiens_hsa040240.82330741
70Salivary secretion_Homo sapiens_hsa049700.81246944
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80733239
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79528680
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.79141028
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.77778119
75Insulin resistance_Homo sapiens_hsa049310.77609699
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77173565
77Parkinsons disease_Homo sapiens_hsa050120.76066352
78Ovarian steroidogenesis_Homo sapiens_hsa049130.73977602
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72435388
80Oxidative phosphorylation_Homo sapiens_hsa001900.72301721
81Pancreatic secretion_Homo sapiens_hsa049720.71721103
82Lysine degradation_Homo sapiens_hsa003100.70201426
83Glucagon signaling pathway_Homo sapiens_hsa049220.67348881
84Glycerolipid metabolism_Homo sapiens_hsa005610.67240344
85Melanogenesis_Homo sapiens_hsa049160.66326340
86Folate biosynthesis_Homo sapiens_hsa007900.64250156
87Sulfur relay system_Homo sapiens_hsa041220.64068274
88Estrogen signaling pathway_Homo sapiens_hsa049150.62563005
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61222031
90GABAergic synapse_Homo sapiens_hsa047270.60290918
91Glioma_Homo sapiens_hsa052140.59151338
92Glutathione metabolism_Homo sapiens_hsa004800.58435025
93Adherens junction_Homo sapiens_hsa045200.57520389
94Cholinergic synapse_Homo sapiens_hsa047250.57394471
95Insulin signaling pathway_Homo sapiens_hsa049100.56459648
96Synaptic vesicle cycle_Homo sapiens_hsa047210.54832266
97VEGF signaling pathway_Homo sapiens_hsa043700.54584315
98Alzheimers disease_Homo sapiens_hsa050100.54296965
99Galactose metabolism_Homo sapiens_hsa000520.53818864
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52971492
101Gap junction_Homo sapiens_hsa045400.52435745
102Fructose and mannose metabolism_Homo sapiens_hsa000510.52321405
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49100258
104AMPK signaling pathway_Homo sapiens_hsa041520.48937526
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48273949
106Dopaminergic synapse_Homo sapiens_hsa047280.47082416
107Pentose phosphate pathway_Homo sapiens_hsa000300.46563465
108Renal cell carcinoma_Homo sapiens_hsa052110.46559000
109MAPK signaling pathway_Homo sapiens_hsa040100.46338398
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46157719
111Proteoglycans in cancer_Homo sapiens_hsa052050.44976090
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44648132
113Inositol phosphate metabolism_Homo sapiens_hsa005620.44377494
114FoxO signaling pathway_Homo sapiens_hsa040680.44037718
115mTOR signaling pathway_Homo sapiens_hsa041500.43538815
116Glutamatergic synapse_Homo sapiens_hsa047240.42275296
117Metabolic pathways_Homo sapiens_hsa011000.41564458
118Endometrial cancer_Homo sapiens_hsa052130.39792701
119Thyroid hormone synthesis_Homo sapiens_hsa049180.39142009
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.37963915
121HIF-1 signaling pathway_Homo sapiens_hsa040660.36945671
122Cocaine addiction_Homo sapiens_hsa050300.36432895
123Morphine addiction_Homo sapiens_hsa050320.35989882
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.35702212
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35402547
126ErbB signaling pathway_Homo sapiens_hsa040120.34929549
127Steroid biosynthesis_Homo sapiens_hsa001000.34917044
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.33161757
129Vitamin B6 metabolism_Homo sapiens_hsa007500.32127574
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.31809331
131Prion diseases_Homo sapiens_hsa050200.27437667
132Linoleic acid metabolism_Homo sapiens_hsa005910.26844591
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26197083
134Vitamin digestion and absorption_Homo sapiens_hsa049770.25056087
135Huntingtons disease_Homo sapiens_hsa050160.22622289
136Amoebiasis_Homo sapiens_hsa051460.20058018
137ECM-receptor interaction_Homo sapiens_hsa045120.16732210
138Focal adhesion_Homo sapiens_hsa045100.16543291
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16073799
140Viral myocarditis_Homo sapiens_hsa054160.15382851
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.15265458
142Tight junction_Homo sapiens_hsa045300.12797795
143Circadian rhythm_Homo sapiens_hsa047100.07810771
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04662911
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.03405529
146Bladder cancer_Homo sapiens_hsa052190.03248837
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02736624

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