HSPB2-C11ORF52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.49234233
2skeletal muscle contraction (GO:0003009)8.89595599
3sarcoplasmic reticulum calcium ion transport (GO:0070296)8.45080330
4regulation of skeletal muscle contraction (GO:0014819)8.37552680
5sarcomere organization (GO:0045214)7.14156549
6actin filament-based movement (GO:0030048)7.05572628
7myofibril assembly (GO:0030239)7.03474476
8striated muscle contraction (GO:0006941)6.64407336
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.58527672
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.53485427
11response to inactivity (GO:0014854)6.41517898
12cardiac myofibril assembly (GO:0055003)6.33857291
13response to muscle activity (GO:0014850)6.13826565
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.00896976
15regulation of relaxation of muscle (GO:1901077)5.85192669
16negative regulation of potassium ion transmembrane transport (GO:1901380)5.84071279
17skeletal muscle fiber development (GO:0048741)5.69583274
18plasma membrane repair (GO:0001778)5.60071992
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.57680253
20cardiac muscle contraction (GO:0060048)5.42569201
21positive regulation of myotube differentiation (GO:0010831)5.40030546
22actomyosin structure organization (GO:0031032)5.39409820
23myotube cell development (GO:0014904)5.19520333
24muscle cell fate commitment (GO:0042693)5.10972954
25muscle contraction (GO:0006936)5.10233247
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.88693272
27regulation of cell communication by electrical coupling (GO:0010649)4.85768402
28muscle cell cellular homeostasis (GO:0046716)4.83635664
29creatine metabolic process (GO:0006600)4.80218224
30negative regulation of protein localization to cell surface (GO:2000009)4.72023367
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.67783624
32muscle system process (GO:0003012)4.62791292
33skeletal muscle tissue development (GO:0007519)4.60190819
34striated muscle atrophy (GO:0014891)4.56574997
35regulation of sarcomere organization (GO:0060297)4.52476316
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.47417320
37regulation of actin filament-based movement (GO:1903115)4.36340257
38regulation of striated muscle contraction (GO:0006942)4.35117942
39positive regulation of myoblast differentiation (GO:0045663)4.30704831
40muscle organ development (GO:0007517)4.25865377
41cardiac muscle hypertrophy (GO:0003300)4.20896948
42muscle structure development (GO:0061061)4.19487362
43muscle fiber development (GO:0048747)4.19226879
44striated muscle adaptation (GO:0014888)4.17583889
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.16959950
46cardiac muscle cell development (GO:0055013)4.09908056
47striated muscle hypertrophy (GO:0014897)4.06214308
48skeletal muscle adaptation (GO:0043501)4.03532986
49muscle atrophy (GO:0014889)4.01781285
50muscle tissue morphogenesis (GO:0060415)4.00944329
51NADH metabolic process (GO:0006734)3.99404981
52myoblast fusion (GO:0007520)3.90740997
53heart process (GO:0003015)3.88744520
54heart contraction (GO:0060047)3.88744520
55cardiac muscle tissue morphogenesis (GO:0055008)3.86604720
56cardiac cell development (GO:0055006)3.81767631
57skeletal muscle tissue regeneration (GO:0043403)3.77922645
58striated muscle cell development (GO:0055002)3.74059405
59muscle hypertrophy (GO:0014896)3.67381768
60regulation of membrane repolarization (GO:0060306)3.65743430
61regulation of the force of heart contraction (GO:0002026)3.64199101
62regulation of myoblast differentiation (GO:0045661)3.63602276
63regulation of calcium ion transmembrane transporter activity (GO:1901019)3.52586221
64regulation of calcium ion transmembrane transport (GO:1903169)3.52586221
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47574874
66glycogen biosynthetic process (GO:0005978)3.47201645
67glucan biosynthetic process (GO:0009250)3.47201645
68regulation of skeletal muscle cell differentiation (GO:2001014)3.42978290
69syncytium formation by plasma membrane fusion (GO:0000768)3.40205227
70striated muscle tissue development (GO:0014706)3.39839866
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.39563822
72regulation of muscle system process (GO:0090257)3.37072417
73muscle adaptation (GO:0043500)3.34426697
74muscle cell development (GO:0055001)3.31468138
75regulation of sequestering of triglyceride (GO:0010889)3.30170146
76negative regulation of calcium ion transmembrane transport (GO:1903170)3.29519912
77negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.29519912
78regulation of muscle contraction (GO:0006937)3.28690525
79adult heart development (GO:0007512)3.25464303
80glycogen catabolic process (GO:0005980)3.24410409
81regulation of myotube differentiation (GO:0010830)3.23452045
82cardiac muscle adaptation (GO:0014887)3.22011971
83cardiac muscle hypertrophy in response to stress (GO:0014898)3.22011971
84muscle hypertrophy in response to stress (GO:0003299)3.22011971
85negative regulation of nitric-oxide synthase activity (GO:0051001)3.18975989
86regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.18666564
87myotube differentiation (GO:0014902)3.17415939
88muscle tissue development (GO:0060537)3.11278386
89negative regulation of muscle hypertrophy (GO:0014741)3.09474412
90negative regulation of heart growth (GO:0061117)3.01658609
91negative regulation of cardiac muscle tissue growth (GO:0055022)3.01658609
92glucan catabolic process (GO:0009251)3.01003246
93regulation of skeletal muscle fiber development (GO:0048742)3.00566457
94negative regulation of potassium ion transport (GO:0043267)2.99278369
95ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.90195176
96positive regulation of striated muscle cell differentiation (GO:0051155)2.85194516
97regulation of ATP catabolic process (GO:1903289)2.82518319
98regulation of ATPase activity (GO:0043462)2.82518319
99muscle filament sliding (GO:0030049)11.3291987
100actin-myosin filament sliding (GO:0033275)11.3291987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.12136054
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.64078407
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.07006502
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.00248815
5EZH2_22144423_ChIP-Seq_EOC_Human2.95722144
6TBX20_22328084_ChIP-Seq_HEART_Mouse2.86382404
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.86382404
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85487283
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81731223
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.57399137
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.47451171
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30198727
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.23546113
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.19566447
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13986806
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.09878877
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08934487
18PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.98584396
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92635536
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89150024
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86210083
22CLOCK_20551151_ChIP-Seq_293T_Human1.80535580
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77713583
24NFIB_24661679_ChIP-Seq_LUNG_Mouse1.76535777
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75014206
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61546801
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61546801
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59720780
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55120854
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52915688
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51662847
32SMC3_22415368_ChIP-Seq_MEFs_Mouse1.50536766
33NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.50513788
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45835868
35GATA4_21415370_ChIP-Seq_HL-1_Mouse1.45743644
36CJUN_26792858_Chip-Seq_BT549_Human1.41305691
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.40046913
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.38585096
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35947359
40ZNF263_19887448_ChIP-Seq_K562_Human1.34586970
41CTCF_27219007_Chip-Seq_Bcells_Human1.33335247
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32924611
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32557054
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32450460
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31457778
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.30901187
47SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22228587
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21000191
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.19869660
50RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18643599
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17793625
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.17727973
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17549112
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.16980371
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15824732
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13254124
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12284564
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.10142540
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10013064
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10013064
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09122235
62DROSHA_22980978_ChIP-Seq_HELA_Human1.07634309
63GATA1_22025678_ChIP-Seq_K562_Human1.07323097
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07248967
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06590370
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.03245596
67SA1_22415368_ChIP-Seq_MEFs_Mouse1.03208986
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02578511
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97164341
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96468956
71RNF2_27304074_Chip-Seq_ESCs_Mouse0.95247334
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94466077
73SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93391264
74ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93334001
75WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93313702
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93185465
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91842226
78SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90950965
79MYC_27129775_Chip-Seq_CORNEA_Mouse0.90114356
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89276202
81RXR_22158963_ChIP-Seq_LIVER_Mouse0.88534449
82CRX_20693478_ChIP-Seq_RETINA_Mouse0.88293777
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87392288
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87202931
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87066761
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85562949
87BRD4_25478319_ChIP-Seq_HGPS_Human0.84916908
88DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84697690
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84519783
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83888699
91STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81844942
92NFI_21473784_ChIP-Seq_ESCs_Mouse0.81234711
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.80396468
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80080601
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79015262
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.77947990
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.77529632
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76233035
99LXR_22292898_ChIP-Seq_THP-1_Human0.75932181
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.75374643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy6.40549784
2MP0000749_muscle_degeneration5.82374946
3MP0004145_abnormal_muscle_electrophysio4.89529800
4MP0003646_muscle_fatigue4.11671742
5MP0004084_abnormal_cardiac_muscle3.91065079
6MP0004036_abnormal_muscle_relaxation3.89231122
7MP0008438_abnormal_cutaneous_collagen3.45884409
8MP0004087_abnormal_muscle_fiber3.32689697
9MP0000759_abnormal_skeletal_muscle3.29620184
10MP0002106_abnormal_muscle_physiology3.18406594
11MP0000747_muscle_weakness3.08391533
12MP0000750_abnormal_muscle_regeneration3.04871798
13MP0005369_muscle_phenotype2.87648820
14MP0002269_muscular_atrophy2.81825989
15MP0002837_dystrophic_cardiac_calcinosis2.76553555
16MP0005620_abnormal_muscle_contractility2.75312000
17MP0003950_abnormal_plasma_membrane2.73576894
18MP0005330_cardiomyopathy2.67949075
19MP0002108_abnormal_muscle_morphology2.63704098
20MP0004215_abnormal_myocardial_fiber2.32432874
21MP0002972_abnormal_cardiac_muscle2.27857576
22MP0005275_abnormal_skin_tensile2.27179052
23MP0005503_abnormal_tendon_morphology2.19835179
24MP0004233_abnormal_muscle_weight2.18781266
25MP0000733_abnormal_muscle_development2.17345997
26MP0004130_abnormal_muscle_cell2.12308035
27MP0002332_abnormal_exercise_endurance2.03267128
28MP0004484_altered_response_of1.86709762
29MP0003279_aneurysm1.82290998
30MP0003705_abnormal_hypodermis_morpholog1.73879327
31MP0004270_analgesia1.72204279
32MP0010630_abnormal_cardiac_muscle1.69534700
33MP0000013_abnormal_adipose_tissue1.65836941
34MP0005670_abnormal_white_adipose1.63786672
35MP0005385_cardiovascular_system_phenoty1.60902264
36MP0001544_abnormal_cardiovascular_syste1.60902264
37MP0006138_congestive_heart_failure1.57875087
38MP0005451_abnormal_body_composition1.53189900
39MP0004510_myositis1.48088689
40MP0004272_abnormal_basement_membrane1.47841981
41MP0001958_emphysema1.46244949
42MP0001542_abnormal_bone_strength1.31497012
43MP0002127_abnormal_cardiovascular_syste1.28220609
44MP0003137_abnormal_impulse_conducting1.24961304
45MP0002971_abnormal_brown_adipose1.20816648
46MP0008775_abnormal_heart_ventricle1.18316202
47MP0009780_abnormal_chondrocyte_physiolo1.16959921
48MP0003828_pulmonary_edema1.13260842
49MP0006036_abnormal_mitochondrial_physio1.05504134
50MP0010368_abnormal_lymphatic_system1.03679875
51MP0000003_abnormal_adipose_tissue1.01635825
52MP0005375_adipose_tissue_phenotype0.98520294
53MP0001299_abnormal_eye_distance/0.97075066
54MP0001661_extended_life_span0.96544443
55MP0010030_abnormal_orbit_morphology0.92557549
56MP0000767_abnormal_smooth_muscle0.91329211
57MP0005666_abnormal_adipose_tissue0.91244056
58MP0004085_abnormal_heartbeat0.90275475
59MP0009384_cardiac_valve_regurgitation0.89811875
60MP0005266_abnormal_metabolism0.79624295
61MP0003221_abnormal_cardiomyocyte_apopto0.78792128
62MP0005165_increased_susceptibility_to0.78144650
63MP0005595_abnormal_vascular_smooth0.73435364
64MP0005623_abnormal_meninges_morphology0.71892482
65MP0000266_abnormal_heart_morphology0.70098636
66MP0009250_abnormal_appendicular_skeleto0.67701952
67MP0002896_abnormal_bone_mineralization0.66753796
68MP0002128_abnormal_blood_circulation0.65203447
69MP0002249_abnormal_larynx_morphology0.62522057
70MP0002295_abnormal_pulmonary_circulatio0.60506018
71MP0000762_abnormal_tongue_morphology0.59796925
72MP0002933_joint_inflammation0.59276280
73MP0003045_fibrosis0.57601807
74MP0004134_abnormal_chest_morphology0.55907848
75MP0005508_abnormal_skeleton_morphology0.55091219
76MP0004185_abnormal_adipocyte_glucose0.54814499
77MP0000343_altered_response_to0.54396247
78MP0002114_abnormal_axial_skeleton0.50935225
79MP0000230_abnormal_systemic_arterial0.48171713
80MP0003879_abnormal_hair_cell0.48031391
81MP0001879_abnormal_lymphatic_vessel0.47842069
82MP0003566_abnormal_cell_adhesion0.46689115
83MP0004858_abnormal_nervous_system0.43699301
84MP0002060_abnormal_skin_morphology0.43642295
85MP0005171_absent_coat_pigmentation0.43538401
86MP0000372_irregular_coat_pigmentation0.43069082
87MP0003941_abnormal_skin_development0.42762319
88MP0005257_abnormal_intraocular_pressure0.40783252
89MP0002234_abnormal_pharynx_morphology0.35732569
90MP0003385_abnormal_body_wall0.34574658
91MP0003948_abnormal_gas_homeostasis0.33508141
92MP0000534_abnormal_ureter_morphology0.33405974
93MP0003959_abnormal_lean_body0.32329583
94MP0000163_abnormal_cartilage_morphology0.31915728
95MP0008569_lethality_at_weaning0.31796360
96MP0005452_abnormal_adipose_tissue0.30328576
97MP0003091_abnormal_cell_migration0.29769947
98MP0005023_abnormal_wound_healing0.29449578
99MP0009115_abnormal_fat_cell0.28830662
100MP0001614_abnormal_blood_vessel0.28696985

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.58948582
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.18504873
3Muscle fiber inclusion bodies (HP:0100299)8.16792130
4Distal arthrogryposis (HP:0005684)7.37297834
5Type 1 muscle fiber predominance (HP:0003803)7.31061354
6Round ear (HP:0100830)6.43534337
7Exercise-induced myalgia (HP:0003738)6.30879571
8Ulnar deviation of the wrist (HP:0003049)5.91866750
9Muscle hypertrophy of the lower extremities (HP:0008968)5.55461418
10Exercise-induced muscle cramps (HP:0003710)5.50663539
11Calf muscle hypertrophy (HP:0008981)5.42582216
12Calcaneovalgus deformity (HP:0001848)5.10696374
13Hyporeflexia of lower limbs (HP:0002600)4.93368452
14Abnormality of the calf musculature (HP:0001430)4.67373486
15Muscle fiber splitting (HP:0003555)4.66228634
16Deformed tarsal bones (HP:0008119)4.57729946
17Sudden death (HP:0001699)4.41287072
18Popliteal pterygium (HP:0009756)4.41101502
19EMG: myopathic abnormalities (HP:0003458)4.32935919
20Malignant hyperthermia (HP:0002047)4.29088874
21Myopathic facies (HP:0002058)4.28966812
22Absent phalangeal crease (HP:0006109)4.19719003
23Neck muscle weakness (HP:0000467)4.19422428
24Fetal akinesia sequence (HP:0001989)4.07911856
25Subaortic stenosis (HP:0001682)4.04131241
26Abnormality of the left ventricular outflow tract (HP:0011103)4.04131241
27Abnormality of skeletal muscle fiber size (HP:0012084)4.04001285
28Asymmetric septal hypertrophy (HP:0001670)3.91029787
29Increased variability in muscle fiber diameter (HP:0003557)3.78439698
30Distal lower limb muscle weakness (HP:0009053)3.74478932
31Increased connective tissue (HP:0009025)3.73134069
32Centrally nucleated skeletal muscle fibers (HP:0003687)3.46175950
33Abnormal finger flexion creases (HP:0006143)3.44385143
34Gowers sign (HP:0003391)3.42467135
35Abnormality of placental membranes (HP:0011409)3.28231729
36Amniotic constriction ring (HP:0009775)3.28231729
37Abnormality of the neuromuscular junction (HP:0003398)3.27527113
38Fatigable weakness (HP:0003473)3.27527113
39Difficulty running (HP:0009046)3.24818602
40Myotonia (HP:0002486)3.20415671
41Rhabdomyolysis (HP:0003201)3.16336282
42Myoglobinuria (HP:0002913)3.11956444
43Bundle branch block (HP:0011710)3.10583883
44Type 2 muscle fiber atrophy (HP:0003554)3.07247825
45Weak cry (HP:0001612)3.06015214
46Aplasia of the musculature (HP:0100854)3.05546418
47Muscle stiffness (HP:0003552)2.94542039
48Abnormality of the calcaneus (HP:0008364)2.94028493
49Mildly elevated creatine phosphokinase (HP:0008180)2.93633774
50Hip contracture (HP:0003273)2.88140956
51Lipoatrophy (HP:0100578)2.82977181
52Muscle fiber atrophy (HP:0100295)2.80216710
53Rimmed vacuoles (HP:0003805)2.79154148
54Areflexia of lower limbs (HP:0002522)2.78409212
55Bulbar palsy (HP:0001283)2.67756333
56EMG: neuropathic changes (HP:0003445)2.63887535
57Ventricular tachycardia (HP:0004756)2.57915733
58Metatarsus adductus (HP:0001840)2.54952761
59Breech presentation (HP:0001623)2.54351621
60Scapular winging (HP:0003691)2.50439401
61Dilated cardiomyopathy (HP:0001644)2.46853236
62Generalized muscle weakness (HP:0003324)2.45477489
63Limb-girdle muscle atrophy (HP:0003797)2.45074316
64Protrusio acetabuli (HP:0003179)2.45022652
65Spinal rigidity (HP:0003306)2.42315762
66Slender build (HP:0001533)2.41870339
67Frequent falls (HP:0002359)2.41841532
68Trismus (HP:0000211)2.26020179
69Respiratory insufficiency due to muscle weakness (HP:0002747)2.25740706
70Thin ribs (HP:0000883)2.25270921
71Limited hip movement (HP:0008800)2.21404772
72Distal lower limb amyotrophy (HP:0008944)2.14974165
73Easy fatigability (HP:0003388)2.14703802
74Pterygium (HP:0001059)2.09382155
75Aortic aneurysm (HP:0004942)2.07364475
76Heart block (HP:0012722)2.02717521
77Nonprogressive disorder (HP:0003680)2.00988216
78Abnormal atrioventricular conduction (HP:0005150)2.00735418
79Ventricular arrhythmia (HP:0004308)2.00591862
80Premature rupture of membranes (HP:0001788)1.94820146
81Atrial fibrillation (HP:0005110)1.93089870
82Long clavicles (HP:0000890)1.92794584
83Akinesia (HP:0002304)1.90968360
84Waddling gait (HP:0002515)1.85103857
85Difficulty climbing stairs (HP:0003551)1.84411275
86Abnormality of the foot musculature (HP:0001436)1.83957301
87Hypoplastic heart (HP:0001961)1.81904113
88Abnormality of the shoulder girdle musculature (HP:0001435)1.81724746
89Limb-girdle muscle weakness (HP:0003325)1.77815606
90Proximal amyotrophy (HP:0007126)1.77248960
91Foot dorsiflexor weakness (HP:0009027)1.73650374
92Generalized amyotrophy (HP:0003700)1.73471572
93Primary atrial arrhythmia (HP:0001692)1.72876617
94Muscular dystrophy (HP:0003560)1.71333704
95Supraventricular tachycardia (HP:0004755)1.67411188
96Supraventricular arrhythmia (HP:0005115)1.64736736
97Lower limb amyotrophy (HP:0007210)1.63438002
98Facial diplegia (HP:0001349)1.63289900
99Aortic dissection (HP:0002647)1.56791811
100Atrioventricular block (HP:0001678)1.56290173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.27283470
2TTN5.76712278
3MUSK4.91080102
4PHKG24.17942374
5PHKG14.17942374
6PIK3CG3.98099450
7MYLK2.80384350
8LIMK12.17348396
9MOS2.13888637
10DMPK2.03873736
11MAPK121.98900666
12MAPKAPK31.81326116
13TRPM71.65892822
14MAP3K71.58134792
15DDR21.54757098
16TRIB31.39323968
17CCNB11.38904027
18PINK11.38384879
19MARK11.21506982
20EEF2K1.19699262
21RIPK11.15138979
22MAP2K31.15092968
23NEK91.11120476
24TIE11.08858840
25MAPK71.07026583
26TGFBR21.01311415
27CAMK2G1.00448673
28MAP2K10.92964289
29ROCK10.91276109
30CAMK2D0.87917776
31PDGFRA0.87154583
32PIK3CA0.86922029
33LATS20.85075790
34TESK10.84742330
35PRKAA20.70246133
36MAPK40.68729785
37ILK0.66761078
38NME10.66507890
39PRKG10.64856489
40CAMK10.64332583
41EPHB20.62174300
42CAMK2A0.59799552
43AKT20.58397717
44PRKAA10.58271881
45ROCK20.57675483
46DAPK30.56714263
47CDC42BPA0.56523875
48MAPKAPK50.55400131
49PRKD10.53416008
50PAK20.52855970
51PDK20.51210432
52PKN10.51136766
53ARAF0.51090810
54KSR20.51068164
55DYRK1B0.50610160
56CAMK2B0.50183971
57MAP2K40.50005054
58SIK10.47803050
59PAK30.47645203
60NEK10.45394976
61EPHB10.42299058
62PTK20.42156448
63MARK20.41014791
64CAMK40.40793930
65PAK60.40094327
66ERBB30.39952475
67MAP3K120.39400534
68ABL20.38549925
69MAP3K60.37533925
70BCKDK0.36184894
71LATS10.35857867
72PRKACB0.33912741
73PRKACA0.32780985
74MAPK110.32484453
75PKN20.31749158
76PAK40.31333656
77FGFR40.30943750
78PRKG20.30512335
79RPS6KA30.29482463
80MAP3K130.28795032
81GRK50.27573743
82PTK2B0.27307495
83MTOR0.26986572
84PRKD20.26556581
85MAP3K30.25628407
86PDPK10.24259677
87ICK0.22006134
88PRKD30.21684764
89MAP3K50.21656670
90PRKACG0.19367107
91SGK30.19187042
92CDK80.19019502
93NLK0.18859243
94MAP3K100.18805543
95MAP2K60.18749460
96GRK70.18227224
97PRPF4B0.16513507
98MAPK100.16402898
99RPS6KL10.14352335
100RPS6KC10.14352335

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.18365126
2Dilated cardiomyopathy_Homo sapiens_hsa054144.95689159
3Cardiac muscle contraction_Homo sapiens_hsa042604.20644137
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.75941964
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.07245226
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.04199246
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.53288080
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48353192
9Circadian rhythm_Homo sapiens_hsa047101.81782902
10ECM-receptor interaction_Homo sapiens_hsa045121.81557692
11Focal adhesion_Homo sapiens_hsa045101.77736647
12Glucagon signaling pathway_Homo sapiens_hsa049221.74977100
13Arginine and proline metabolism_Homo sapiens_hsa003301.65552472
14Oxytocin signaling pathway_Homo sapiens_hsa049211.63555881
15cGMP-PKG signaling pathway_Homo sapiens_hsa040221.61555253
16Carbon metabolism_Homo sapiens_hsa012001.61339612
17Pyruvate metabolism_Homo sapiens_hsa006201.58449146
18Calcium signaling pathway_Homo sapiens_hsa040201.49569660
19Insulin signaling pathway_Homo sapiens_hsa049101.45903556
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.36523505
21Tight junction_Homo sapiens_hsa045301.34948750
22Alzheimers disease_Homo sapiens_hsa050101.34640217
23Parkinsons disease_Homo sapiens_hsa050121.33419356
24Propanoate metabolism_Homo sapiens_hsa006401.31601593
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29784352
26Fatty acid degradation_Homo sapiens_hsa000711.27870796
27Renin secretion_Homo sapiens_hsa049241.23885325
28Arginine biosynthesis_Homo sapiens_hsa002201.22033619
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21739668
30Pentose phosphate pathway_Homo sapiens_hsa000301.12490763
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09363501
32AMPK signaling pathway_Homo sapiens_hsa041521.07602269
33Insulin resistance_Homo sapiens_hsa049311.05101248
34Gastric acid secretion_Homo sapiens_hsa049711.03630884
35Phenylalanine metabolism_Homo sapiens_hsa003601.01408847
36Protein digestion and absorption_Homo sapiens_hsa049741.00951971
37PPAR signaling pathway_Homo sapiens_hsa033201.00059482
38Viral myocarditis_Homo sapiens_hsa054160.99326909
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98818890
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98657627
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97004857
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95015406
43Oxidative phosphorylation_Homo sapiens_hsa001900.94880267
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94742938
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92823221
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.90121351
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86284506
48Amoebiasis_Homo sapiens_hsa051460.85372676
49Biosynthesis of amino acids_Homo sapiens_hsa012300.83526186
50Fructose and mannose metabolism_Homo sapiens_hsa000510.83276632
51Fatty acid elongation_Homo sapiens_hsa000620.76272833
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75954555
53Proteoglycans in cancer_Homo sapiens_hsa052050.74780601
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72926943
55Long-term potentiation_Homo sapiens_hsa047200.70539377
56Starch and sucrose metabolism_Homo sapiens_hsa005000.68299891
57GnRH signaling pathway_Homo sapiens_hsa049120.68243177
58beta-Alanine metabolism_Homo sapiens_hsa004100.67857460
59Circadian entrainment_Homo sapiens_hsa047130.65106418
60Insulin secretion_Homo sapiens_hsa049110.63186590
61Melanogenesis_Homo sapiens_hsa049160.62968099
62Salivary secretion_Homo sapiens_hsa049700.62635997
63Adherens junction_Homo sapiens_hsa045200.59490521
64Fatty acid metabolism_Homo sapiens_hsa012120.58300794
65cAMP signaling pathway_Homo sapiens_hsa040240.56480343
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54738691
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52404304
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52029537
69Histidine metabolism_Homo sapiens_hsa003400.51838245
70Huntingtons disease_Homo sapiens_hsa050160.49949098
71Gap junction_Homo sapiens_hsa045400.48788608
72Tyrosine metabolism_Homo sapiens_hsa003500.47366867
73Nitrogen metabolism_Homo sapiens_hsa009100.46289238
74Tryptophan metabolism_Homo sapiens_hsa003800.41301617
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40080558
76Ovarian steroidogenesis_Homo sapiens_hsa049130.38770117
77Pancreatic secretion_Homo sapiens_hsa049720.38584969
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.37966564
79Cholinergic synapse_Homo sapiens_hsa047250.37857240
80MAPK signaling pathway_Homo sapiens_hsa040100.37276322
81Prion diseases_Homo sapiens_hsa050200.36094418
82Amphetamine addiction_Homo sapiens_hsa050310.34151564
83Galactose metabolism_Homo sapiens_hsa000520.33874720
84FoxO signaling pathway_Homo sapiens_hsa040680.33861373
85Renin-angiotensin system_Homo sapiens_hsa046140.33796466
86Lysine degradation_Homo sapiens_hsa003100.33453902
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32490121
88Glioma_Homo sapiens_hsa052140.29254164
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28917376
90Platelet activation_Homo sapiens_hsa046110.28107259
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25951967
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25690609
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23768191
94Bile secretion_Homo sapiens_hsa049760.22771449
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20725430
96Long-term depression_Homo sapiens_hsa047300.20411941
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.19447535
98Thyroid hormone synthesis_Homo sapiens_hsa049180.19250751
99Estrogen signaling pathway_Homo sapiens_hsa049150.16698573
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.15674155

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