HSPA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of inclusion body assembly (GO:0090083)8.96883143
2* protein refolding (GO:0042026)8.08615403
3cellular response to arsenic-containing substance (GO:0071243)5.01340135
4positive regulation by symbiont of host defense response (GO:0052509)4.86454479
5modulation by symbiont of host defense response (GO:0052031)4.86454479
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.86454479
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.86454479
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.86454479
9modulation by symbiont of host immune response (GO:0052553)4.86454479
10negative regulation of striated muscle cell apoptotic process (GO:0010664)4.82299049
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81756540
12negative regulation of cell killing (GO:0031342)4.81756540
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72351491
14regulation of MHC class I biosynthetic process (GO:0045343)4.40659652
15macrophage activation involved in immune response (GO:0002281)4.38895193
16neutrophil activation involved in immune response (GO:0002283)4.35476138
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25388789
18detection of molecule of bacterial origin (GO:0032490)4.18531674
19detection of other organism (GO:0098543)4.12357505
20positive regulation of gamma-delta T cell activation (GO:0046645)4.09768513
21response to peptidoglycan (GO:0032494)4.08984444
22antigen processing and presentation of endogenous antigen (GO:0019883)4.00561395
23detection of bacterium (GO:0016045)3.94605674
24microglial cell activation (GO:0001774)3.92557489
25detection of external biotic stimulus (GO:0098581)3.86148366
26negative regulation of interleukin-12 production (GO:0032695)3.83940810
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.83499487
28macrophage activation (GO:0042116)3.83336128
29leukocyte aggregation (GO:0070486)3.64280288
30neutrophil mediated immunity (GO:0002446)3.51531929
31response to host immune response (GO:0052572)3.48821830
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48821830
33purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.45323335
34neutrophil activation (GO:0042119)3.45115270
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43811492
36viral protein processing (GO:0019082)3.43320720
37regulation of interferon-beta biosynthetic process (GO:0045357)3.43271785
38cellular extravasation (GO:0045123)3.42015184
39regulation of mast cell degranulation (GO:0043304)3.40609542
40germinal center formation (GO:0002467)3.40348694
41positive regulation of ATP catabolic process (GO:1903291)3.34808211
42positive regulation of ATPase activity (GO:0032781)3.34808211
43leukocyte migration involved in inflammatory response (GO:0002523)3.34462729
44negative regulation of glycoprotein biosynthetic process (GO:0010561)3.34078324
45negative regulation of leukocyte mediated immunity (GO:0002704)3.33388356
46detection of biotic stimulus (GO:0009595)3.32117300
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.29250974
48respiratory burst (GO:0045730)3.27602195
49regulation of superoxide anion generation (GO:0032928)3.26137135
50regulation of B cell receptor signaling pathway (GO:0050855)3.24950327
51granulocyte activation (GO:0036230)3.24701061
52negative regulation of cytokine production involved in immune response (GO:0002719)3.23592493
53positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16173957
54cellular response to type I interferon (GO:0071357)3.16006163
55type I interferon signaling pathway (GO:0060337)3.16006163
56immunoglobulin mediated immune response (GO:0016064)3.15571897
57response to type I interferon (GO:0034340)3.12819602
582-deoxyribonucleotide biosynthetic process (GO:0009265)3.11935924
59deoxyribose phosphate biosynthetic process (GO:0046385)3.11935924
60regulation of mast cell activation involved in immune response (GO:0033006)3.11922328
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.09979996
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06742214
63response to host (GO:0075136)3.06742214
64response to host defenses (GO:0052200)3.06742214
65regulation of striated muscle cell apoptotic process (GO:0010662)3.06646424
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03163424
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01088388
68regulation of T-helper 2 cell differentiation (GO:0045628)2.96637722
69myeloid cell activation involved in immune response (GO:0002275)2.95117927
70negative regulation of muscle cell apoptotic process (GO:0010656)2.93911195
71purine nucleotide salvage (GO:0032261)2.93311303
72response to muramyl dipeptide (GO:0032495)2.93246888
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93030324
74myeloid leukocyte mediated immunity (GO:0002444)2.91971477
75regulation of leukocyte degranulation (GO:0043300)2.91259992
76chaperone-mediated protein folding (GO:0061077)2.86657339
77regulation of mast cell activation (GO:0033003)2.86466303
78extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.85144835
79regulation of gamma-delta T cell activation (GO:0046643)2.84122686
80negative regulation of T cell mediated immunity (GO:0002710)2.83723143
81production of molecular mediator involved in inflammatory response (GO:0002532)2.81365997
82defense response to protozoan (GO:0042832)2.78823945
83positive regulation of interferon-alpha production (GO:0032727)2.77978114
84response to interleukin-15 (GO:0070672)2.77812354
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77626661
86regulation of interferon-alpha production (GO:0032647)2.75861133
87interferon-gamma-mediated signaling pathway (GO:0060333)2.75394749
88negative regulation of interleukin-6 production (GO:0032715)2.74535531
89de novo posttranslational protein folding (GO:0051084)2.73090381
90B cell mediated immunity (GO:0019724)2.72051304
91positive regulation of monocyte chemotaxis (GO:0090026)2.71589780
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68456334
93negative regulation of T-helper cell differentiation (GO:0045623)2.68456334
94negative regulation of glycoprotein metabolic process (GO:1903019)2.67653988
95positive regulation of mast cell activation (GO:0033005)2.67483462
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63086637
97positive regulation of cellular amide metabolic process (GO:0034250)2.59812665
98cellular response to interleukin-15 (GO:0071350)2.57454834
99negative regulation of inclusion body assembly (GO:0090084)14.7879230
100chaperone mediated protein folding requiring cofactor (GO:0051085)14.3300396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.73816228
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.53684013
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.47829632
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.02796322
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12609255
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03353023
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83654280
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79464083
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76035694
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70059489
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67407920
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.66905707
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57247929
14SPI1_23547873_ChIP-Seq_NB4_Human2.50780332
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34606166
16VDR_24763502_ChIP-Seq_THP-1_Human2.33808001
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32438747
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32284605
19HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.29080583
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24206329
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24033776
22VDR_21846776_ChIP-Seq_THP-1_Human2.22792875
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14590996
24RUNX_20019798_ChIP-Seq_JUKART_Human2.07108310
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06621372
26MAF_26560356_Chip-Seq_TH1_Human2.00399132
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97971625
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91898727
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91519022
30SPI1_23127762_ChIP-Seq_K562_Human1.90359047
31MYB_26560356_Chip-Seq_TH1_Human1.86105952
32* MYB_26560356_Chip-Seq_TH2_Human1.84802673
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79713158
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78857449
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.77815740
36* UTX_26944678_Chip-Seq_JUKART_Human1.77245918
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67968805
38* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66443875
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66271991
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66266317
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.65782822
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57794277
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57611177
44MAF_26560356_Chip-Seq_TH2_Human1.56547280
45TCF7_22412390_ChIP-Seq_EML_Mouse1.53036609
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52237826
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52083650
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51853002
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51116826
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42686102
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36955899
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36892445
53VDR_24787735_ChIP-Seq_THP-1_Human1.33277615
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30867983
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29391064
56* GATA3_27048872_Chip-Seq_THYMUS_Human1.27769977
57CLOCK_20551151_ChIP-Seq_293T_Human1.27136369
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25743602
59KDM2B_26808549_Chip-Seq_DND41_Human1.23816237
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23729188
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22830973
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22023002
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.21220517
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.20104935
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19714503
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18551649
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16147418
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16032170
69* GATA3_26560356_Chip-Seq_TH2_Human1.15452882
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13822070
71MYC_22102868_ChIP-Seq_BL_Human1.12531659
72SCL_19346495_ChIP-Seq_HPC-7_Human1.11851429
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11506171
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.11366751
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11149306
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08659001
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03538783
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03180302
79BCL6_27268052_Chip-Seq_Bcells_Human1.01722308
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01372066
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00230547
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99503495
83TFEB_21752829_ChIP-Seq_HELA_Human0.99125989
84ZNF263_19887448_ChIP-Seq_K562_Human0.97819028
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97579791
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97428658
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92682333
88LXR_22292898_ChIP-Seq_THP-1_Human0.91112137
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89278420
90VDR_23849224_ChIP-Seq_CD4+_Human0.88460453
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88096508
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88009746
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87511229
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.86538794
95BCOR_27268052_Chip-Seq_Bcells_Human0.86188552
96EGR1_19032775_ChIP-ChIP_M12_Human0.84135993
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83468574
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82500359
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81270016
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79196539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003828_pulmonary_edema5.04578371
2MP0003806_abnormal_nucleotide_metabolis4.59194151
3MP0003724_increased_susceptibility_to4.55824166
4MP0003436_decreased_susceptibility_to3.97033487
5MP0003303_peritoneal_inflammation3.52959920
6MP0002132_abnormal_respiratory_system3.17630480
7MP0003221_abnormal_cardiomyocyte_apopto3.16072307
8MP0001835_abnormal_antigen_presentation2.94723781
9MP0009785_altered_susceptibility_to2.88260209
10MP0002419_abnormal_innate_immunity2.73946688
11MP0006082_CNS_inflammation2.58682017
12MP0005025_abnormal_response_to2.56105000
13MP0005000_abnormal_immune_tolerance2.52398490
14MP0001800_abnormal_humoral_immune2.50240140
15MP0000749_muscle_degeneration2.48068054
16MP0001790_abnormal_immune_system2.46953313
17MP0005387_immune_system_phenotype2.46953313
18MP0005671_abnormal_response_to2.42096833
19MP0002723_abnormal_immune_serum2.28155061
20MP0003300_gastrointestinal_ulcer2.22872111
21MP0002148_abnormal_hypersensitivity_rea2.20311856
22MP0000685_abnormal_immune_system2.17426084
23MP0002452_abnormal_antigen_presenting2.15901574
24MP0000343_altered_response_to2.15418878
25MP0008260_abnormal_autophagy2.09865173
26MP0002420_abnormal_adaptive_immunity2.06826239
27MP0001819_abnormal_immune_cell2.04328839
28MP0001533_abnormal_skeleton_physiology1.91469683
29MP0002653_abnormal_ependyma_morphology1.81587394
30MP0003172_abnormal_lysosome_physiology1.71664860
31MP0003075_altered_response_to1.71509132
32MP0002405_respiratory_system_inflammati1.70857039
33MP0002277_abnormal_respiratory_mucosa1.63585503
34MP0005451_abnormal_body_composition1.61184180
35MP0000716_abnormal_immune_system1.60378768
36MP0005058_abnormal_lysosome_morphology1.59179531
37MP0001845_abnormal_inflammatory_respons1.55175700
38MP0009840_abnormal_foam_cell1.43167657
39MP0004947_skin_inflammation1.42271946
40MP0003763_abnormal_thymus_physiology1.36955499
41MP0002398_abnormal_bone_marrow1.36182656
42MP0000689_abnormal_spleen_morphology1.33260520
43MP0002722_abnormal_immune_system1.33078290
44MP0009764_decreased_sensitivity_to1.32536394
45MP0008469_abnormal_protein_level1.32332281
46MP0003191_abnormal_cellular_cholesterol1.31782393
47MP0010155_abnormal_intestine_physiology1.30772242
48MP0000703_abnormal_thymus_morphology1.29613997
49MP0002429_abnormal_blood_cell1.24269865
50MP0004510_myositis1.23950127
51MP0005164_abnormal_response_to1.23802941
52MP0004883_abnormal_blood_vessel1.22840337
53MP0005464_abnormal_platelet_physiology1.21081110
54MP0009333_abnormal_splenocyte_physiolog1.18744632
55MP0003690_abnormal_glial_cell1.16954877
56MP0000465_gastrointestinal_hemorrhage1.16578145
57MP0002332_abnormal_exercise_endurance1.09048869
58MP0009278_abnormal_bone_marrow1.05431485
59MP0005334_abnormal_fat_pad0.99807742
60MP0009763_increased_sensitivity_to0.96572566
61MP0005166_decreased_susceptibility_to0.95962229
62MP0003866_abnormal_defecation0.95797400
63MP0008004_abnormal_stomach_pH0.95181904
64MP0005388_respiratory_system_phenotype0.95015373
65MP0002133_abnormal_respiratory_system0.95015373
66MP0001851_eye_inflammation0.93547026
67MP0005535_abnormal_body_temperature0.93283147
68MP0002998_abnormal_bone_remodeling0.92547832
69MP0005310_abnormal_salivary_gland0.89436163
70MP0000604_amyloidosis0.88415364
71MP0003656_abnormal_erythrocyte_physiolo0.83232819
72MP0003453_abnormal_keratinocyte_physiol0.80421075
73MP0004381_abnormal_hair_follicle0.79015686
74MP0003329_amyloid_beta_deposits0.78491656
75MP0005390_skeleton_phenotype0.76526402
76MP0002970_abnormal_white_adipose0.71206807
77MP0002396_abnormal_hematopoietic_system0.71201624
78MP0001663_abnormal_digestive_system0.70112950
79MP0001764_abnormal_homeostasis0.70045805
80MP0003183_abnormal_peptide_metabolism0.68306779
81MP0000858_altered_metastatic_potential0.66253564
82MP0000015_abnormal_ear_pigmentation0.65971311
83MP0003448_altered_tumor_morphology0.64356262
84MP0001853_heart_inflammation0.62166490
85MP0005397_hematopoietic_system_phenotyp0.61917192
86MP0001545_abnormal_hematopoietic_system0.61917192
87MP0008007_abnormal_cellular_replicative0.60953302
88MP0009765_abnormal_xenobiotic_induced0.59128640
89MP0005376_homeostasis/metabolism_phenot0.56276567
90MP0002928_abnormal_bile_duct0.56149728
91MP0000249_abnormal_blood_vessel0.55358358
92MP0005075_abnormal_melanosome_morpholog0.55156139
93MP0005584_abnormal_enzyme/coenzyme_acti0.54073723
94MP0003795_abnormal_bone_structure0.54005186
95MP0001873_stomach_inflammation0.52959848
96MP0004142_abnormal_muscle_tone0.52845625
97MP0005319_abnormal_enzyme/_coenzyme0.49981869
98MP0008873_increased_physiological_sensi0.47879450
99MP0002693_abnormal_pancreas_physiology0.47271932
100MP0001727_abnormal_embryo_implantation0.46935197

Predicted human phenotypes

RankGene SetZ-score
1Diaphragmatic weakness (HP:0009113)8.91532610
2Easy fatigability (HP:0003388)5.22406465
3Eczematoid dermatitis (HP:0000976)5.01120237
4Orchitis (HP:0100796)4.86756269
5Myositis (HP:0100614)4.81102744
6Abnormality of macrophages (HP:0004311)4.79353073
7Recurrent bacterial skin infections (HP:0005406)4.74527439
8Optic neuritis (HP:0100653)4.73731542
9Retrobulbar optic neuritis (HP:0100654)4.73731542
10Recurrent abscess formation (HP:0002722)4.61972816
11Stomatitis (HP:0010280)3.79142703
12Episodic fever (HP:0001954)3.73080567
13Mediastinal lymphadenopathy (HP:0100721)3.67996987
14Recurrent gram-negative bacterial infections (HP:0005420)3.58376093
15Spinal rigidity (HP:0003306)3.53168489
16Acute hepatic failure (HP:0006554)3.36432780
17Keratoconjunctivitis sicca (HP:0001097)3.34157382
18Elevated erythrocyte sedimentation rate (HP:0003565)3.26656912
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.21246693
20Nuclear cataract (HP:0100018)3.20577292
21Recurrent skin infections (HP:0001581)3.16808892
22Encephalitis (HP:0002383)3.15970156
23Chronic obstructive pulmonary disease (HP:0006510)3.15647156
24Obstructive lung disease (HP:0006536)3.15647156
25Meningitis (HP:0001287)3.14882705
26Muscle fiber splitting (HP:0003555)3.10404128
27Gastrointestinal infarctions (HP:0005244)3.09931874
28Recurrent fungal infections (HP:0002841)3.08056294
29Keratoconjunctivitis (HP:0001096)3.05307040
30Rapidly progressive (HP:0003678)3.00187264
31Nasal speech (HP:0001611)2.90353157
32Generalized amyotrophy (HP:0003700)2.90352464
33Inflammation of the large intestine (HP:0002037)2.90260878
34Abnormality of glycolipid metabolism (HP:0010969)2.88757753
35Abnormality of liposaccharide metabolism (HP:0010968)2.88757753
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.88757753
37Abnormality of the peritoneum (HP:0002585)2.88219088
38EMG: myopathic abnormalities (HP:0003458)2.87258156
39Muscular dystrophy (HP:0003560)2.85440813
40Chronic mucocutaneous candidiasis (HP:0002728)2.80655356
41Recurrent cutaneous fungal infections (HP:0011370)2.80655356
42Gastrointestinal inflammation (HP:0004386)2.74740614
43Urticaria (HP:0001025)2.69410063
44Increased IgE level (HP:0003212)2.67706711
45Anorexia (HP:0002039)2.66722024
46Vasculitis (HP:0002633)2.53168646
47Spontaneous hematomas (HP:0007420)2.47922827
48Loss of speech (HP:0002371)2.42762654
49Glomerulonephritis (HP:0000099)2.41993348
50Hemoptysis (HP:0002105)2.40854456
51Pulmonary infiltrates (HP:0002113)2.39816566
52Abnormality of the pleura (HP:0002103)2.35731748
53Gingivitis (HP:0000230)2.32288231
54Hypochromic microcytic anemia (HP:0004840)2.31018015
55Acute necrotizing encephalopathy (HP:0006965)2.30117540
56Split foot (HP:0001839)2.29627327
57Abnormal mitochondria in muscle tissue (HP:0008316)2.29058010
58Disinhibition (HP:0000734)2.27053895
59Hypochromic anemia (HP:0001931)2.25738112
60Glomerulopathy (HP:0100820)2.23585731
61Parakeratosis (HP:0001036)2.21060697
62Arthropathy (HP:0003040)2.19107722
63Systemic lupus erythematosus (HP:0002725)2.18700385
64Knee flexion contracture (HP:0006380)2.17972354
65Colitis (HP:0002583)2.16307595
66Difficulty climbing stairs (HP:0003551)2.15892703
67Petechiae (HP:0000967)2.10145444
68Pulmonary embolism (HP:0002204)2.06965676
69Prolonged bleeding time (HP:0003010)2.06904373
70Panhypogammaglobulinemia (HP:0003139)2.06800652
71Gangrene (HP:0100758)2.03211167
72Mutism (HP:0002300)2.01271187
73Progressive macrocephaly (HP:0004481)2.00290500
74Axonal loss (HP:0003447)10.2003151
75Lymphopenia (HP:0001888)1.97582684
76Cellulitis (HP:0100658)1.95307127
77Severe visual impairment (HP:0001141)1.94267739
78Abnormality of T cell physiology (HP:0011840)1.92244431
79Cerebral edema (HP:0002181)1.89938378
80Polyneuropathy (HP:0001271)1.89044701
81Hepatosplenomegaly (HP:0001433)1.88827902
82Interstitial pulmonary disease (HP:0006530)1.88023965
83Peritonitis (HP:0002586)1.87328256
84Abnormality of T cells (HP:0002843)1.86479680
85Vacuolated lymphocytes (HP:0001922)1.85480751
86Leukocytosis (HP:0001974)1.84718758
87Recurrent viral infections (HP:0004429)1.84530981
88Amyloidosis (HP:0011034)1.83050094
89Aseptic necrosis (HP:0010885)1.81209652
90Microcytic anemia (HP:0001935)1.81104850
91Gingival bleeding (HP:0000225)1.80087860
92Chest pain (HP:0100749)1.79362155
93Epistaxis (HP:0000421)1.78045141
94Dysostosis multiplex (HP:0000943)1.77424375
95Vertigo (HP:0002321)1.75546700
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.75376109
97Arterial thrombosis (HP:0004420)1.73439864
98Increased IgM level (HP:0003496)1.72453917
99Pustule (HP:0200039)1.70387266
100Increased serum ferritin (HP:0003281)1.68489735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK59.72076886
2BCKDK4.24007751
3TSSK63.37560546
4RIPK42.88813751
5ERN12.72281629
6MAP4K12.33772215
7BLK2.27330423
8MAP2K32.27227343
9IRAK42.26055303
10TNK21.89261174
11FES1.87638796
12TAOK31.80643836
13CSK1.79482377
14TYK21.78840483
15MAP3K111.69255124
16MAP3K131.53834390
17TAOK11.50603833
18PNCK1.41193810
19SIK31.38997560
20MAPK151.37750518
21PRPF4B1.35784979
22MAP3K31.33830918
23JAK31.33821540
24FGR1.33532132
25ARAF1.32075998
26ZAP701.22315136
27TAOK21.19641246
28IRAK11.19432287
29TBK11.19376989
30EPHB11.13636758
31IKBKE1.11873930
32HCK1.11076719
33MAP3K51.09899667
34TXK1.07211769
35GRK61.05125669
36RAF10.99320092
37MAP3K10.97717507
38LYN0.96771638
39IKBKB0.95562158
40MAP3K140.94831913
41KSR20.94278563
42JAK20.93366208
43MARK20.91271147
44MOS0.89545384
45BTK0.89119344
46SYK0.85978499
47GRK70.83460919
48MAPKAPK30.75490377
49PDK20.74731543
50LCK0.73468610
51CSF1R0.70576754
52SIK20.67207748
53YES10.65632339
54EIF2AK30.62811322
55BMPR20.61244850
56WNK40.61064368
57JAK10.58762232
58PIM20.58629319
59MARK30.57386244
60TESK20.55363132
61PDK10.54003515
62PRKCD0.53425509
63SIK10.51407520
64PDPK10.50618429
65BRD40.50055384
66IRAK20.49938426
67MAP2K60.48857494
68MATK0.48431608
69TGFBR20.48213655
70PTK2B0.47218302
71KSR10.45974680
72PRKD20.42863513
73KIT0.42071535
74DYRK1B0.41297025
75STK100.39150064
76MAP2K40.38129722
77MAPKAPK20.37026735
78MAP3K60.36686633
79EPHA30.36489507
80MAPK120.31163027
81FYN0.31038538
82ITK0.30833805
83PIM10.30527447
84CHUK0.29319607
85PRKD10.29178994
86STK110.27093948
87WNK10.27076326
88PRKG20.25598166
89PIK3CG0.24413667
90RET0.24141644
91PDGFRB0.21943925
92MAP2K20.21389211
93MAP3K70.21109626
94PTK60.20220968
95MTOR0.19134914
96CDC42BPA0.18822917
97PRKCQ0.18785180
98MAPK70.18726782
99DAPK20.18177908
100PKN10.17547305

Predicted pathways (KEGG)

RankGene SetZ-score
1* Legionellosis_Homo sapiens_hsa051342.99312427
2Osteoclast differentiation_Homo sapiens_hsa043802.78209783
3Leishmaniasis_Homo sapiens_hsa051402.75111700
4Staphylococcus aureus infection_Homo sapiens_hsa051502.72350268
5* Influenza A_Homo sapiens_hsa051642.46342815
6* Antigen processing and presentation_Homo sapiens_hsa046122.35017446
7Other glycan degradation_Homo sapiens_hsa005112.32741467
8Tuberculosis_Homo sapiens_hsa051522.24230088
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21017581
10Allograft rejection_Homo sapiens_hsa053302.16084776
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10476419
12Graft-versus-host disease_Homo sapiens_hsa053322.07166157
13Autoimmune thyroid disease_Homo sapiens_hsa053201.90524455
14Malaria_Homo sapiens_hsa051441.84079998
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81811732
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79506557
17* Toxoplasmosis_Homo sapiens_hsa051451.77357884
18Rheumatoid arthritis_Homo sapiens_hsa053231.77309913
19* Measles_Homo sapiens_hsa051621.76447202
20Collecting duct acid secretion_Homo sapiens_hsa049661.71800180
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70961345
22B cell receptor signaling pathway_Homo sapiens_hsa046621.69696783
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.66388150
24TNF signaling pathway_Homo sapiens_hsa046681.63313605
25Type I diabetes mellitus_Homo sapiens_hsa049401.60414264
26Phagosome_Homo sapiens_hsa041451.57203241
27Primary immunodeficiency_Homo sapiens_hsa053401.48436637
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.47535151
29Chemokine signaling pathway_Homo sapiens_hsa040621.46221239
30* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45132326
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39820805
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.37537674
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35538049
34Prion diseases_Homo sapiens_hsa050201.34997995
35Viral myocarditis_Homo sapiens_hsa054161.33330420
36T cell receptor signaling pathway_Homo sapiens_hsa046601.31375460
37Salmonella infection_Homo sapiens_hsa051321.29995547
38African trypanosomiasis_Homo sapiens_hsa051431.29537330
39Hematopoietic cell lineage_Homo sapiens_hsa046401.29507727
40Lysosome_Homo sapiens_hsa041421.28523078
41Pertussis_Homo sapiens_hsa051331.26674324
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25429021
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25062404
44Asthma_Homo sapiens_hsa053101.24343858
45Regulation of autophagy_Homo sapiens_hsa041401.18062378
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16037774
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.13651620
48Herpes simplex infection_Homo sapiens_hsa051681.10733206
49* Epstein-Barr virus infection_Homo sapiens_hsa051691.08831764
50Hepatitis B_Homo sapiens_hsa051611.04347354
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04057560
52* Estrogen signaling pathway_Homo sapiens_hsa049151.01399688
53Proteasome_Homo sapiens_hsa030501.01338090
54Acute myeloid leukemia_Homo sapiens_hsa052211.00840018
55Protein export_Homo sapiens_hsa030600.99612353
56* Endocytosis_Homo sapiens_hsa041440.99220799
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96623869
58Apoptosis_Homo sapiens_hsa042100.95453477
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95002638
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94784048
61Hepatitis C_Homo sapiens_hsa051600.93410613
62Shigellosis_Homo sapiens_hsa051310.92532087
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91213881
64VEGF signaling pathway_Homo sapiens_hsa043700.87628376
65Vibrio cholerae infection_Homo sapiens_hsa051100.82163013
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77538244
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.68994590
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60964277
69Notch signaling pathway_Homo sapiens_hsa043300.58500537
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56732646
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.55825948
72* MAPK signaling pathway_Homo sapiens_hsa040100.55438501
73Synaptic vesicle cycle_Homo sapiens_hsa047210.52598689
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48412945
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46783020
76Non-small cell lung cancer_Homo sapiens_hsa052230.46182976
77Amoebiasis_Homo sapiens_hsa051460.43609549
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.43277092
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43050282
80ErbB signaling pathway_Homo sapiens_hsa040120.42962874
81Platelet activation_Homo sapiens_hsa046110.38711398
82Folate biosynthesis_Homo sapiens_hsa007900.38683687
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.38228013
84* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37794836
85Choline metabolism in cancer_Homo sapiens_hsa052310.34749379
86GnRH signaling pathway_Homo sapiens_hsa049120.34432482
87Prolactin signaling pathway_Homo sapiens_hsa049170.34402255
88Arachidonic acid metabolism_Homo sapiens_hsa005900.32735313
89FoxO signaling pathway_Homo sapiens_hsa040680.31886895
90Viral carcinogenesis_Homo sapiens_hsa052030.30628445
91Dorso-ventral axis formation_Homo sapiens_hsa043200.30198632
92Pancreatic cancer_Homo sapiens_hsa052120.30155443
93Renal cell carcinoma_Homo sapiens_hsa052110.29765880
94HIF-1 signaling pathway_Homo sapiens_hsa040660.29433070
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.27765921
96Sulfur metabolism_Homo sapiens_hsa009200.27105135
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24789258
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.24698341
99Morphine addiction_Homo sapiens_hsa050320.20808983
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.19391174

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