HSPA1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.86848698
2axonemal dynein complex assembly (GO:0070286)9.86814720
3* cell-cell recognition (GO:0009988)9.83184087
4* binding of sperm to zona pellucida (GO:0007339)9.79038160
5motile cilium assembly (GO:0044458)9.44695219
6reproduction (GO:0000003)9.36973109
7cilium or flagellum-dependent cell motility (GO:0001539)9.04449750
8regulation of cilium movement (GO:0003352)8.81276158
9cilium movement (GO:0003341)8.33964503
10negative regulation of inclusion body assembly (GO:0090084)7.53205495
11sperm capacitation (GO:0048240)7.50197932
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.44010370
13single fertilization (GO:0007338)7.38932093
14synaptonemal complex organization (GO:0070193)6.93619492
15synaptonemal complex assembly (GO:0007130)6.73308105
16spermatogenesis (GO:0007283)6.72259813
17male gamete generation (GO:0048232)6.69823686
18male meiosis (GO:0007140)6.67205872
19organic cation transport (GO:0015695)6.58930615
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54597715
21response to pheromone (GO:0019236)6.43859936
22piRNA metabolic process (GO:0034587)6.42773532
23microtubule depolymerization (GO:0007019)6.39793631
24regulation of inclusion body assembly (GO:0090083)6.28313561
25fertilization (GO:0009566)6.24669089
26gamete generation (GO:0007276)6.15383491
27calcium ion-dependent exocytosis (GO:0017156)5.81568966
28protein targeting to Golgi (GO:0000042)5.81263324
29phosphatidylethanolamine biosynthetic process (GO:0006646)5.76097177
30spermatid nucleus differentiation (GO:0007289)5.72341667
31histone H3-K9 demethylation (GO:0033169)5.71005061
32rRNA methylation (GO:0031167)5.53707089
33establishment of protein localization to Golgi (GO:0072600)5.46436625
34germ cell development (GO:0007281)5.41926601
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.37207777
36retrograde transport, vesicle recycling within Golgi (GO:0000301)5.36580305
37phosphatidylethanolamine metabolic process (GO:0046337)5.35506485
38ventricular system development (GO:0021591)5.33799411
39chromosome condensation (GO:0030261)5.27614556
40regulation of microtubule-based movement (GO:0060632)5.16661174
41glycerol ether metabolic process (GO:0006662)5.03762685
42DNA packaging (GO:0006323)4.95779999
43multicellular organismal reproductive process (GO:0048609)4.85519773
44sexual reproduction (GO:0019953)4.80444773
45* cell recognition (GO:0008037)4.72301049
46microtubule severing (GO:0051013)4.70697860
47ether metabolic process (GO:0018904)4.68613209
48left/right pattern formation (GO:0060972)4.57449493
49male meiosis I (GO:0007141)4.57327018
50chromosome organization involved in meiosis (GO:0070192)4.46569243
51seminiferous tubule development (GO:0072520)4.41896107
52regulation of Rab GTPase activity (GO:0032313)4.38800888
53positive regulation of Rab GTPase activity (GO:0032851)4.38800888
54centriole replication (GO:0007099)4.35915497
55rRNA modification (GO:0000154)4.32438314
56single strand break repair (GO:0000012)4.15814808
57protein localization to Golgi apparatus (GO:0034067)4.14640769
58cellular ketone body metabolic process (GO:0046950)4.14514658
59histone H3-K36 demethylation (GO:0070544)4.09519007
60centriole assembly (GO:0098534)4.08504269
61negative regulation of Rho protein signal transduction (GO:0035024)4.05394908
62DNA methylation involved in gamete generation (GO:0043046)4.03643257
63chaperone-mediated protein complex assembly (GO:0051131)4.00993876
64meiotic nuclear division (GO:0007126)3.96303159
65multicellular organismal development (GO:0007275)3.89421077
66sequestering of actin monomers (GO:0042989)3.85675443
67microtubule nucleation (GO:0007020)3.60821069
68genitalia morphogenesis (GO:0035112)3.60813354
69meiosis I (GO:0007127)3.59249494
70regulation of transcription involved in cell fate commitment (GO:0060850)3.56797361
71regulation of meiosis I (GO:0060631)3.55778344
72ketone body metabolic process (GO:1902224)3.54844040
73protein polyglutamylation (GO:0018095)3.54313978
74regulation of T-helper 2 cell differentiation (GO:0045628)3.53535936
75protein K11-linked deubiquitination (GO:0035871)3.46424088
76glycolytic process (GO:0006096)3.45339498
77monoubiquitinated protein deubiquitination (GO:0035520)3.40237648
78microtubule polymerization or depolymerization (GO:0031109)3.38076294
79amino-acid betaine transport (GO:0015838)3.36561406
80carnitine transport (GO:0015879)3.36561406
81response to acidic pH (GO:0010447)3.29336360
82musculoskeletal movement (GO:0050881)3.25486656
83multicellular organismal movement (GO:0050879)3.25486656
84regulation of histone H3-K9 methylation (GO:0051570)3.25483255
85regulation of centriole replication (GO:0046599)3.24803897
86carnitine transmembrane transport (GO:1902603)3.20975117
87peptidyl-threonine dephosphorylation (GO:0035970)3.15603258
88meiotic cell cycle (GO:0051321)3.13978039
89nucleus organization (GO:0006997)3.12641473
90negative regulation of histone methylation (GO:0031061)3.12425356
91nucleoside diphosphate phosphorylation (GO:0006165)3.09701355
92cellular response to pH (GO:0071467)3.08906716
93cerebral cortex neuron differentiation (GO:0021895)3.08772782
94protein localization to cilium (GO:0061512)3.06816374
95regulation of spindle checkpoint (GO:0090231)3.04535876
96negative regulation of gene expression, epigenetic (GO:0045814)3.01074131
97histone demethylation (GO:0016577)2.97686985
98histone lysine demethylation (GO:0070076)2.97359612
99RNA destabilization (GO:0050779)2.96190522
100polyamine biosynthetic process (GO:0006596)2.96142860
101RNA localization (GO:0006403)2.95736651
102homeostasis of number of cells within a tissue (GO:0048873)2.92100131
103mitotic sister chromatid cohesion (GO:0007064)2.88765458
104polyol catabolic process (GO:0046174)2.87807702
105positive regulation of macrophage activation (GO:0043032)2.86884067
106chromatin silencing (GO:0006342)2.85306471
107cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.83863310
108microtubule-based movement (GO:0007018)2.83768691
109cilium organization (GO:0044782)2.81131320
110regulation of interleukin-13 production (GO:0032656)2.80528321
111gene silencing (GO:0016458)2.78686178
112alditol metabolic process (GO:0019400)2.77154759
113regulation of ARF GTPase activity (GO:0032312)2.77140844
114negative regulation of skeletal muscle tissue development (GO:0048642)2.74953679
115protein-DNA complex disassembly (GO:0032986)2.72801785
116negative regulation of organelle assembly (GO:1902116)2.71872627
117axoneme assembly (GO:0035082)2.71765573
118intraciliary transport (GO:0042073)2.71222647
119cellular component assembly involved in morphogenesis (GO:0010927)2.71115473
120regulation of cilium assembly (GO:1902017)2.67596159
121GTP biosynthetic process (GO:0006183)2.67536295
122cilium assembly (GO:0042384)2.67080674
123interferon-gamma secretion (GO:0072643)2.66745705
124positive regulation of glycolytic process (GO:0045821)2.63152758
125meiotic cell cycle process (GO:1903046)2.58150333
126mitochondrion degradation (GO:0000422)2.54510988
127lactate metabolic process (GO:0006089)2.52244921
128cilium morphogenesis (GO:0060271)2.48839664
129calcium ion import (GO:0070509)2.47505323
130peptidyl-glutamic acid modification (GO:0018200)2.44671961
131synapsis (GO:0007129)2.43390101
132sperm motility (GO:0030317)14.3919224
133fusion of sperm to egg plasma membrane (GO:0007342)13.1459437
134cell wall macromolecule metabolic process (GO:0044036)13.1367961
135cell wall macromolecule catabolic process (GO:0016998)13.1367961
136acrosome reaction (GO:0007340)12.4640306
137acrosome assembly (GO:0001675)11.2053049
138* sperm-egg recognition (GO:0035036)10.9950362
139multicellular organism reproduction (GO:0032504)10.6740977
140epithelial cilium movement (GO:0003351)10.1969998
141plasma membrane fusion (GO:0045026)10.0610008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.77133184
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.45818730
3EZH2_22144423_ChIP-Seq_EOC_Human4.38306482
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36852924
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.98369116
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10410604
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.04750939
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94234737
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75211776
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65432328
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.53414637
12VDR_22108803_ChIP-Seq_LS180_Human2.45905099
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.31813663
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15544008
15RUNX_20019798_ChIP-Seq_JUKART_Human2.12947640
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.04801938
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02878098
18BCL6_27268052_Chip-Seq_Bcells_Human2.00074964
19ZNF274_21170338_ChIP-Seq_K562_Hela1.98504427
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92807885
21ERA_21632823_ChIP-Seq_H3396_Human1.92597222
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88852726
23RAC3_21632823_ChIP-Seq_H3396_Human1.86939702
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.84405941
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78077895
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77637989
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.77421097
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71078296
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69962729
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69703294
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68973192
32P68_20966046_ChIP-Seq_HELA_Human1.67600419
33E2F1_20622854_ChIP-Seq_HELA_Human1.67495497
34SMC4_20622854_ChIP-Seq_HELA_Human1.66924600
35STAT1_17558387_ChIP-Seq_HELA_Human1.65738494
36PHF8_20622854_ChIP-Seq_HELA_Human1.59895966
37SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58927127
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57694656
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.57532770
40CTCF_27219007_Chip-Seq_Bcells_Human1.54268960
41TAF2_19829295_ChIP-Seq_ESCs_Human1.51859675
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51708302
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.49799031
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48525646
45P300_27268052_Chip-Seq_Bcells_Human1.46779159
46CBP_20019798_ChIP-Seq_JUKART_Human1.45400508
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45400508
48DROSHA_22980978_ChIP-Seq_HELA_Human1.45318369
49MYC_19829295_ChIP-Seq_ESCs_Human1.45249050
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44686599
51KDM2B_26808549_Chip-Seq_REH_Human1.42816155
52TP63_22573176_ChIP-Seq_HFKS_Human1.42119066
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42040678
54REST_21632747_ChIP-Seq_MESCs_Mouse1.42006589
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41362675
56ER_23166858_ChIP-Seq_MCF-7_Human1.41350630
57LXR_22292898_ChIP-Seq_THP-1_Human1.40734737
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38485001
59SMRT_27268052_Chip-Seq_Bcells_Human1.37595259
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34995477
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.34806033
62P53_21459846_ChIP-Seq_SAOS-2_Human1.34714336
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.34252965
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33908922
65OCT4_20526341_ChIP-Seq_ESCs_Human1.33890532
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31960791
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29025164
68P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.27362430
69VDR_24787735_ChIP-Seq_THP-1_Human1.25951194
70GATA3_21867929_ChIP-Seq_TH1_Mouse1.25762387
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25277957
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22763933
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22051401
74* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21968221
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.21562659
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.21405422
77RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20975247
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20716045
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20278862
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19862994
81CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18128519
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18075736
83GF1_26923725_Chip-Seq_HPCs_Mouse1.18020709
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.17609793
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17561379
86* CEBPB_22108803_ChIP-Seq_LS180_Human1.17075844
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16554017
88CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16257869
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16165102
90RBPJ_21746931_ChIP-Seq_IB4_Human1.16082976
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.16036097
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.15899041
93HNFA_21074721_ChIP-Seq_CACO-2_Human1.15147173
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14747802
95SA1_27219007_Chip-Seq_Bcells_Human1.14641041
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14634535
97AR_25329375_ChIP-Seq_VCAP_Human1.14107582
98TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.14006015
99MYB_26560356_Chip-Seq_TH2_Human1.13398336
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12904148
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12904148
102ETV1_20927104_ChIP-Seq_GIST48_Human1.12628661
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12312660
104EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12150974
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12072910
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12039154
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10967131
108MAF_26560356_Chip-Seq_TH2_Human1.10477758
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.10250006
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10150393
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08564587
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08426203
113SPI1_26923725_Chip-Seq_HPCs_Mouse1.08033639
114GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07615336
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06654557
116BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.06448890
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05870238
118PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05831273
119OCT4_19829295_ChIP-Seq_ESCs_Human1.05709229
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04718314
121* MYC_27129775_Chip-Seq_CORNEA_Mouse1.04403638
122ERG_20517297_ChIP-Seq_VCAP_Human1.04375794
123SPI1_23127762_ChIP-Seq_K562_Human1.04357087
124FUS_26573619_Chip-Seq_HEK293_Human1.03437397
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03344375
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03325052
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03219934
128GATA3_26560356_Chip-Seq_TH1_Human1.02902300
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02741929
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.02608994
131KLF4_19829295_ChIP-Seq_ESCs_Human1.02581762
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02536626
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01554827
134CTCF_21964334_Chip-Seq_Bcells_Human1.00354962
135* TET1_21451524_ChIP-Seq_MESCs_Mouse1.00350929
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99637121
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.99597926
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99524135
139CTCF_20526341_ChIP-Seq_ESCs_Human0.99277321
140JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99267438
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99099384
142GATA6_21074721_ChIP-Seq_CACO-2_Human0.98424729
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.98038093
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.97720474
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96324540
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.96281311
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96262667
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95224042
149NANOG_20526341_ChIP-Seq_ESCs_Human0.94783298
150PHF8_20622853_ChIP-Seq_HELA_Human0.94645523
151STAT1_20625510_ChIP-Seq_HELA_Human0.93765877
152* YY1_22570637_ChIP-Seq_MALME-3M_Human0.93230127
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92693122
154SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92493610
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.91621707
156GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91350943
157OCT4_18555785_Chip-Seq_ESCs_Mouse0.91333094
158NFYB_21822215_ChIP-Seq_K562_Human0.91303089
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90862775
160CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90793062
161TP63_19390658_ChIP-ChIP_HaCaT_Human0.90755086
162BCOR_27268052_Chip-Seq_Bcells_Human0.90627938
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.90573670
164P53_22387025_ChIP-Seq_ESCs_Mouse0.90283840
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.89867276
166SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89538957
167TAF15_26573619_Chip-Seq_HEK293_Human0.89483523
168TBL1_22424771_ChIP-Seq_293T_Human0.87811442
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86803433
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86641801
171SMAD4_21741376_ChIP-Seq_EPCs_Human0.86533068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.92359565
2MP0001929_abnormal_gametogenesis5.31607842
3MP0005451_abnormal_body_composition4.34369986
4MP0008877_abnormal_DNA_methylation3.43138929
5MP0000678_abnormal_parathyroid_gland3.22017829
6MP0002161_abnormal_fertility/fecundity3.21587918
7MP0002210_abnormal_sex_determination3.12257574
8MP0005670_abnormal_white_adipose3.09146317
9MP0001348_abnormal_lacrimal_gland2.94412637
10MP0001145_abnormal_male_reproductive2.63858418
11MP0003646_muscle_fatigue2.61446346
12MP0002132_abnormal_respiratory_system2.55360764
13MP0003718_maternal_effect2.42428798
14MP0000653_abnormal_sex_gland2.27401586
15MP0002653_abnormal_ependyma_morphology2.10063488
16MP0005310_abnormal_salivary_gland2.02472423
17MP0005410_abnormal_fertilization16.3129899
18MP0004233_abnormal_muscle_weight1.74302455
19MP0004510_myositis1.69917850
20MP0002138_abnormal_hepatobiliary_system1.54888659
21MP0003436_decreased_susceptibility_to1.46753269
22MP0002822_catalepsy1.46589981
23MP0005623_abnormal_meninges_morphology1.42725149
24MP0002160_abnormal_reproductive_system1.31595831
25MP0005423_abnormal_somatic_nervous1.25479467
26MP0004145_abnormal_muscle_electrophysio1.22985730
27MP0005083_abnormal_biliary_tract1.20426666
28MP0001765_abnormal_ion_homeostasis1.20130813
29MP0000751_myopathy1.18987556
30MP0005671_abnormal_response_to1.17714649
31MP0004742_abnormal_vestibular_system1.14741816
32MP0005379_endocrine/exocrine_gland_phen1.14492522
33MP0001486_abnormal_startle_reflex1.12239995
34MP0004036_abnormal_muscle_relaxation1.11526088
35MP0009785_altered_susceptibility_to1.11052480
36MP0002735_abnormal_chemical_nociception1.09007440
37MP0005395_other_phenotype1.08738568
38MP0002282_abnormal_trachea_morphology1.08139724
39MP0002249_abnormal_larynx_morphology1.03274998
40MP0002269_muscular_atrophy1.00776050
41MP0005025_abnormal_response_to0.99280062
42MP0002723_abnormal_immune_serum0.98489914
43MP0002419_abnormal_innate_immunity0.96410858
44MP0002127_abnormal_cardiovascular_syste0.92705574
45MP0001835_abnormal_antigen_presentation0.92015235
46MP0002234_abnormal_pharynx_morphology0.89891006
47MP0001485_abnormal_pinna_reflex0.89498772
48MP0000749_muscle_degeneration0.89322754
49MP0003303_peritoneal_inflammation0.89148958
50MP0001800_abnormal_humoral_immune0.89073635
51MP0009046_muscle_twitch0.88966846
52MP0001963_abnormal_hearing_physiology0.85746313
53MP0001984_abnormal_olfaction0.85107152
54MP0003724_increased_susceptibility_to0.83840332
55MP0005666_abnormal_adipose_tissue0.79344138
56MP0000703_abnormal_thymus_morphology0.77796383
57MP0000685_abnormal_immune_system0.76235427
58MP0002420_abnormal_adaptive_immunity0.75655829
59MP0005000_abnormal_immune_tolerance0.74893849
60MP0002452_abnormal_antigen_presenting0.73677113
61MP0001819_abnormal_immune_cell0.73074455
62MP0004130_abnormal_muscle_cell0.72874742
63MP0003115_abnormal_respiratory_system0.69533315
64MP0008995_early_reproductive_senescence0.69235885
65MP0001119_abnormal_female_reproductive0.69082432
66MP0002106_abnormal_muscle_physiology0.67694257
67MP0003011_delayed_dark_adaptation0.66836672
68MP0004087_abnormal_muscle_fiber0.64500992
69MP0002722_abnormal_immune_system0.64332322
70MP0006036_abnormal_mitochondrial_physio0.64058186
71MP0004859_abnormal_synaptic_plasticity0.63988297
72MP0001533_abnormal_skeleton_physiology0.63884711
73MP0005387_immune_system_phenotype0.63667897
74MP0001790_abnormal_immune_system0.63667897
75MP0005636_abnormal_mineral_homeostasis0.62341067
76MP0005647_abnormal_sex_gland0.62337644
77MP0005389_reproductive_system_phenotype0.60216915
78MP0003763_abnormal_thymus_physiology0.59631630
79MP0002837_dystrophic_cardiac_calcinosis0.59474227
80MP0002733_abnormal_thermal_nociception0.59217379
81MP0003329_amyloid_beta_deposits0.58822382
82MP0008874_decreased_physiological_sensi0.58621370
83MP0009278_abnormal_bone_marrow0.57800060
84MP0000026_abnormal_inner_ear0.57174060
85MP0002398_abnormal_bone_marrow0.57109400
86MP0000955_abnormal_spinal_cord0.55854879
87MP0004947_skin_inflammation0.55652500
88MP0008789_abnormal_olfactory_epithelium0.55636974
89MP0008469_abnormal_protein_level0.55606154
90MP0009764_decreased_sensitivity_to0.54227627
91MP0000759_abnormal_skeletal_muscle0.53406905
92MP0000681_abnormal_thyroid_gland0.53378712
93MP0002405_respiratory_system_inflammati0.52485113
94MP0002067_abnormal_sensory_capabilities0.52359392
95MP0000716_abnormal_immune_system0.51759607
96MP0004484_altered_response_of0.51644342
97MP0005377_hearing/vestibular/ear_phenot0.50867890
98MP0003878_abnormal_ear_physiology0.50867890
99MP0000358_abnormal_cell_content/0.50797439
100MP0004270_analgesia0.50264222
101MP0003786_premature_aging0.50005991
102MP0004084_abnormal_cardiac_muscle0.49668011
103MP0005166_decreased_susceptibility_to0.49396646
104MP0005369_muscle_phenotype0.49275924
105MP0008058_abnormal_DNA_repair0.49193251
106MP0005167_abnormal_blood-brain_barrier0.48926776
107MP0000249_abnormal_blood_vessel0.48442448
108MP0003828_pulmonary_edema0.47877082
109MP0002971_abnormal_brown_adipose0.47492305
110MP0003448_altered_tumor_morphology0.45959495
111MP0005535_abnormal_body_temperature0.45896407
112MP0001905_abnormal_dopamine_level0.45400650
113MP0005397_hematopoietic_system_phenotyp0.44619464
114MP0001545_abnormal_hematopoietic_system0.44619464
115MP0000534_abnormal_ureter_morphology0.44371542
116MP0003950_abnormal_plasma_membrane0.44291712
117MP0002734_abnormal_mechanical_nocicepti0.44196801
118MP0009765_abnormal_xenobiotic_induced0.43043065
119MP0002277_abnormal_respiratory_mucosa0.42958198
120MP0005620_abnormal_muscle_contractility0.42737682
121MP0001970_abnormal_pain_threshold0.42735117
122MP0009115_abnormal_fat_cell0.42610355
123MP0001324_abnormal_eye_pigmentation0.39659586
124MP0003699_abnormal_female_reproductive0.39050923
125MP0002736_abnormal_nociception_after0.38800467
126MP0002928_abnormal_bile_duct0.38514729
127MP0002108_abnormal_muscle_morphology0.38184365
128MP0006035_abnormal_mitochondrial_morpho0.37985900
129MP0001764_abnormal_homeostasis0.37802182
130MP0003879_abnormal_hair_cell0.37034491
131MP0008569_lethality_at_weaning0.36058859
132MP0005551_abnormal_eye_electrophysiolog0.35176203
133MP0001293_anophthalmia0.35132672
134MP0001727_abnormal_embryo_implantation0.34257710
135MP0005375_adipose_tissue_phenotype0.33771836
136MP0004811_abnormal_neuron_physiology0.33621048
137MP0003633_abnormal_nervous_system0.33586006
138MP0010630_abnormal_cardiac_muscle0.32714392
139MP0001849_ear_inflammation0.31675693
140MP0005253_abnormal_eye_physiology0.31032834
141MP0000604_amyloidosis0.28248979
142MP0001968_abnormal_touch/_nociception0.28044614
143MP0000733_abnormal_muscle_development0.27776957
144MP0002909_abnormal_adrenal_gland0.27337827
145MP0008961_abnormal_basal_metabolism0.26712109
146MP0002139_abnormal_hepatobiliary_system0.26327044
147MP0003948_abnormal_gas_homeostasis0.25509562
148MP0003631_nervous_system_phenotype0.24925072
149MP0000750_abnormal_muscle_regeneration0.23708880
150MP0004043_abnormal_pH_regulation0.22362199
151MP0003942_abnormal_urinary_system0.22344757
152MP0002169_no_abnormal_phenotype0.22089125
153MP0003959_abnormal_lean_body0.21947329
154MP0002873_normal_phenotype0.21896408
155MP0002295_abnormal_pulmonary_circulatio0.21520934
156MP0005391_vision/eye_phenotype0.21225119
157MP0002152_abnormal_brain_morphology0.20469045
158MP0002572_abnormal_emotion/affect_behav0.20367891
159MP0009672_abnormal_birth_weight0.19244343
160MP0000569_abnormal_digit_pigmentation0.18875146
161MP0005319_abnormal_enzyme/_coenzyme0.17726041
162MP0004085_abnormal_heartbeat0.17503013
163MP0003861_abnormal_nervous_system0.17246838
164MP0010094_abnormal_chromosome_stability0.16763925
165MP0001440_abnormal_grooming_behavior0.16447460
166MP0001730_embryonic_growth_arrest0.16125708
167MP0003635_abnormal_synaptic_transmissio0.16071804
168MP0002229_neurodegeneration0.15796998
169MP0002272_abnormal_nervous_system0.15003363

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.15720305
2Abnormal respiratory motile cilium morphology (HP:0005938)9.15689518
3Abnormal respiratory epithelium morphology (HP:0012253)9.15689518
4Severe visual impairment (HP:0001141)7.64705215
5Rhinitis (HP:0012384)7.35960851
6Abnormal ciliary motility (HP:0012262)7.23327090
7Chronic bronchitis (HP:0004469)7.03353453
8Infertility (HP:0000789)6.87267889
9Nasal polyposis (HP:0100582)6.36143999
10Abnormality of the nasal mucosa (HP:0000433)5.24754339
11Male infertility (HP:0003251)4.91603620
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.90284195
13Resting tremor (HP:0002322)4.77899450
14Bronchitis (HP:0012387)4.45148830
15Bronchiectasis (HP:0002110)4.29068246
16Bony spicule pigmentary retinopathy (HP:0007737)4.19002654
17Nephronophthisis (HP:0000090)4.04764467
18Abnormal rod and cone electroretinograms (HP:0008323)3.74330930
19Attenuation of retinal blood vessels (HP:0007843)3.73237103
20Osteomalacia (HP:0002749)3.70889309
21Abnormal spermatogenesis (HP:0008669)3.56507880
22Chronic hepatic failure (HP:0100626)3.48655976
23Menstrual irregularities (HP:0000858)3.40540670
24Hypoplastic ischia (HP:0003175)3.40002507
25Cone-rod dystrophy (HP:0000548)3.36449525
26Abnormality of macular pigmentation (HP:0008002)3.31332363
27Abnormality of the ischium (HP:0003174)3.21255104
28Recurrent sinusitis (HP:0011108)3.17899219
29Recurrent otitis media (HP:0000403)3.17364182
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.15992520
31Postural instability (HP:0002172)3.10564281
32Abnormality of the renal medulla (HP:0100957)2.97948916
33Gingivitis (HP:0000230)2.94878885
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.94822862
35Tubulointerstitial nephritis (HP:0001970)2.90931133
36Cholecystitis (HP:0001082)2.88421089
37Abnormal gallbladder physiology (HP:0012438)2.88421089
38Recurrent bronchitis (HP:0002837)2.73012415
39Hypoalphalipoproteinemia (HP:0003233)2.72910972
40Gastrointestinal infarctions (HP:0005244)2.68678531
41Facial shape deformation (HP:0011334)2.65460635
42Potter facies (HP:0002009)2.65460635
43Enlarged epiphyses (HP:0010580)2.60124258
44Abnormality of potassium homeostasis (HP:0011042)2.57418307
45Horizontal nystagmus (HP:0000666)2.53839123
46Abnormality of macrophages (HP:0004311)2.48257081
47Exercise-induced myalgia (HP:0003738)2.47785316
48Tubular atrophy (HP:0000092)2.42000077
49Impulsivity (HP:0100710)2.39017026
50Progressive sensorineural hearing impairment (HP:0000408)2.36240471
51Tubulointerstitial abnormality (HP:0001969)2.36162803
52Abnormality of midbrain morphology (HP:0002418)2.34626935
53Molar tooth sign on MRI (HP:0002419)2.34626935
54Recurrent pneumonia (HP:0006532)2.30833506
55Gonadotropin excess (HP:0000837)2.30115261
56Dyschromatopsia (HP:0007641)2.29867985
57Hypoplasia of the thymus (HP:0000778)2.29166053
58Elevated erythrocyte sedimentation rate (HP:0003565)2.27567305
59Asymmetric septal hypertrophy (HP:0001670)2.22688353
60Azoospermia (HP:0000027)2.22584290
61Progressive cerebellar ataxia (HP:0002073)2.20080759
62Peripheral hypomyelination (HP:0007182)2.18127587
63Insulin-resistant diabetes mellitus (HP:0000831)2.15584090
64Generalized aminoaciduria (HP:0002909)2.14586064
65Myositis (HP:0100614)2.12428967
66Medial flaring of the eyebrow (HP:0010747)2.11200028
67Abnormality of dental color (HP:0011073)2.07818252
68Exercise-induced muscle cramps (HP:0003710)2.06066605
69Obstructive lung disease (HP:0006536)2.05863556
70Chronic obstructive pulmonary disease (HP:0006510)2.05863556
71Abnormality of chloride homeostasis (HP:0011422)2.00908894
72Dynein arm defect of respiratory motile cilia (HP:0012255)13.2319811
73Absent/shortened dynein arms (HP:0200106)13.2319811
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7310919
75Choroideremia (HP:0001139)1.98066121
76Portal hypertension (HP:0001409)1.96415965
77Ventricular tachycardia (HP:0004756)1.96106363
78Short nail (HP:0001799)1.95911511
79Hyponatremia (HP:0002902)1.95735449
80Recurrent bacterial skin infections (HP:0005406)1.94354744
81Hypochromic microcytic anemia (HP:0004840)1.94300915
82Bowel incontinence (HP:0002607)1.93249939
83Myoglobinuria (HP:0002913)1.92341082
84Retrobulbar optic neuritis (HP:0100654)1.92258305
85Optic neuritis (HP:0100653)1.92258305
86Flattened epiphyses (HP:0003071)1.87652799
87Bundle branch block (HP:0011710)1.85629351
88Abnormality of the costochondral junction (HP:0000919)1.85169629
89Spastic tetraparesis (HP:0001285)1.82169319
90Orchitis (HP:0100796)1.81952428
91Abnormal large intestine physiology (HP:0012700)1.80696729
92Slow saccadic eye movements (HP:0000514)1.79313067
93Tubulointerstitial fibrosis (HP:0005576)1.78233835
94Hyporeflexia of lower limbs (HP:0002600)1.77633280
95Decreased central vision (HP:0007663)1.76853333
96Abnormal biliary tract physiology (HP:0012439)1.75840826
97Bile duct proliferation (HP:0001408)1.75840826
98Abnormality of the pubic bones (HP:0003172)1.75407810
99Recurrent abscess formation (HP:0002722)1.74039059
100Abnormality of the dental root (HP:0006486)1.73456434
101Taurodontia (HP:0000679)1.73456434
102Abnormality of permanent molar morphology (HP:0011071)1.73456434
103Atelectasis (HP:0100750)1.72830307
104Rhabdomyolysis (HP:0003201)1.72358328
105Abnormality of the hepatic vasculature (HP:0006707)1.72139358
106Stage 5 chronic kidney disease (HP:0003774)1.70483632
107Heterotopia (HP:0002282)1.70002745
108Abnormality of dentin (HP:0010299)1.68494364
109Congenital hepatic fibrosis (HP:0002612)1.67832460
110Peritonitis (HP:0002586)1.67807641
111Abnormality of the aortic arch (HP:0012303)1.67409183
112Bell-shaped thorax (HP:0001591)1.67117504
113Abnormality of the parathyroid morphology (HP:0011766)1.64976469
114Abnormality of molar (HP:0011077)1.63520585
115Abnormality of molar morphology (HP:0011070)1.63520585
116Tetany (HP:0001281)1.62511744
117Abnormal drinking behavior (HP:0030082)1.61771080
118Polydipsia (HP:0001959)1.61771080
119Congenital malformation of the right heart (HP:0011723)1.61131571
120Double outlet right ventricle (HP:0001719)1.61131571
121Hemorrhage of the eye (HP:0011885)1.59170481
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.59033986
123Increased purine levels (HP:0004368)1.58916591
124Hyperuricemia (HP:0002149)1.58916591
125Abnormality of the dental pulp (HP:0006479)1.58825235
126Photophobia (HP:0000613)1.58620745
127Amelogenesis imperfecta (HP:0000705)1.58125240
128Oligodactyly (hands) (HP:0001180)1.58016025
129Widely patent fontanelles and sutures (HP:0004492)1.55848233
130Postaxial foot polydactyly (HP:0001830)1.55615362
131Difficulty climbing stairs (HP:0003551)1.55513249
132Eczematoid dermatitis (HP:0000976)1.53498951
133Fatigable weakness (HP:0003473)1.53293567
134Abnormality of the neuromuscular junction (HP:0003398)1.53293567
135Neurofibrillary tangles (HP:0002185)1.51639521
136Short ribs (HP:0000773)1.49924885
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.47189872
138Abnormality of the renal cortex (HP:0011035)1.45962209
139Abnormality of renal excretion (HP:0011036)1.45801039
140Easy fatigability (HP:0003388)1.42165690
141Generalized muscle weakness (HP:0003324)1.40448106
142Difficulty running (HP:0009046)1.38566537
143Oculomotor apraxia (HP:0000657)1.37780371
144Ulnar deviation of the wrist (HP:0003049)1.36766847
145Constricted visual fields (HP:0001133)1.36760267
146EMG: neuropathic changes (HP:0003445)1.32617447
147Cerebral inclusion bodies (HP:0100314)1.32347381
148Bulbar palsy (HP:0001283)1.31888507
149Hyperkalemia (HP:0002153)1.31238200
150Chronic sinusitis (HP:0011109)1.30607752
151Abnormality of the lower motor neuron (HP:0002366)1.29993093
152Aplasia/Hypoplasia of the lens (HP:0008063)1.29571782
153Deformed sella turcica (HP:0002681)1.28113046
154Postaxial hand polydactyly (HP:0001162)1.26808577
155Fibular hypoplasia (HP:0003038)1.26740652
156Facial cleft (HP:0002006)1.23992612
157Sensory axonal neuropathy (HP:0003390)1.23626886
158Renal dysplasia (HP:0000110)1.21828126
159Abnormal urine output (HP:0012590)1.21473477
160Cerebellar dysplasia (HP:0007033)1.20925829
161Hemiparesis (HP:0001269)1.20195459
162Cystic liver disease (HP:0006706)1.19951483
163Truncal obesity (HP:0001956)1.18369900
164Broad distal phalanx of finger (HP:0009836)1.17879170
165Abnormality of saccadic eye movements (HP:0000570)1.17586690
166Loss of speech (HP:0002371)1.16747785
167Hypercholesterolemia (HP:0003124)1.16492834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.20913132
2PDK48.20913132
3TESK16.20430105
4PDK25.24134984
5PRKD35.20996244
6ICK4.49053691
7DDR23.36725752
8INSRR2.52334681
9BRD42.36447501
10PLK22.21122167
11PTK2B2.19884710
12STK162.14637211
13MAP3K92.07358405
14WNK41.97707731
15PNCK1.93114671
16STK381.90184264
17STK391.82179920
18CDK121.78762318
19DYRK1B1.71187370
20SIK21.65175240
21MET1.63980155
22MAP4K21.49476603
23CDK191.40136758
24NEK21.35800408
25ARAF1.22825328
26PDK11.20979121
27MAP3K21.19100069
28FGR1.15595000
29BRAF1.13475114
30MAP3K131.06945627
31BLK1.01790309
32CDK70.95855255
33MST1R0.93473306
34CSK0.92462284
35CAMK1D0.84709687
36TAOK30.84512768
37MAP3K110.84176445
38OBSCN0.78568571
39MAPK150.76475783
40NEK90.76004696
41WNK10.74146682
42PDPK10.74048694
43JAK30.72510489
44BMX0.72409802
45EEF2K0.71977750
46TYRO30.71030377
47CDK40.69895019
48MOS0.69358749
49LMTK20.68592844
50IRAK40.68012957
51PINK10.67658434
52MAP2K60.67568437
53RIPK40.66741284
54DYRK30.65942442
55IRAK10.65299433
56MAP4K10.64699465
57CCNB10.64440857
58RET0.64059243
59AKT30.63918894
60STK30.61875392
61ERN10.61821139
62TTN0.55655361
63NTRK30.53533146
64TNK20.51173912
65MUSK0.49717609
66CAMK1G0.48022267
67TTK0.47904841
68PASK0.47105529
69PRPF4B0.44135838
70MAP3K80.43700163
71CHEK20.42254942
72ITK0.41542045
73SGK10.41530423
74TXK0.41420227
75TBK10.41160234
76SGK2230.40380276
77SGK4940.40380276
78FES0.39838829
79PAK10.39836702
80STK38L0.39550764
81CAMKK10.38282368
82PAK60.38138393
83LATS20.37190541
84ZAP700.36033316
85JAK20.35546737
86PKN20.35232026
87SYK0.34909955
88PRKCG0.33637097
89PHKG20.33348168
90PHKG10.33348168
91HCK0.33297194
92PAK20.32831330
93BRSK20.31628880
94PRKAA10.31497239
95MAPK10.31493477
96ROCK10.31413666
97MARK20.31320480
98NTRK20.30585278
99BTK0.30452635
100TESK20.30309131
101OXSR10.30032737
102RAF10.29761060
103CHEK10.28254814
104MAP3K100.28155525
105SGK20.28093600
106MAP2K20.28088220
107CDK20.27779544
108IKBKB0.27012162
109TRIB30.26604950
110TAOK10.25355778
111MTOR0.24650693
112IRAK20.24365583
113KSR10.22415243
114GRK60.22209338
115UHMK10.21949624
116TAOK20.21841427
117ATM0.18500068
118MAPKAPK50.18183270
119PKN10.16917826
120PAK40.16589818
121PRKCZ0.15041289
122PIK3CG0.14738857
123BRSK10.14163036
124PRKCQ0.13601023
125RPS6KB10.12843382
126CDK150.10852539
127MAP3K10.10191822
128STK110.10138517
129STK100.09809473
130RPS6KA10.09606850
131MAP2K30.08215098
132CDK180.07728859
133KSR20.07621529
134CDK11A0.06921223
135WEE10.05498547
136MAP3K50.05195794
137ATR0.05087397
138PRKACG0.04640321
139CDK140.04593776
140GSK3B0.04316735
141PRKG10.03896093
142CAMK2A0.03095987
143PRKACB0.03042536
144MAP3K30.02869759
145MAPK80.02614855
146NEK60.02374730
147PRKAA20.02270849
148PLK40.02118750
149CSNK1D0.01023362
150RPS6KA30.00650756
151CAMK10.00537021
152CSF1R0.00429573
153PDGFRB-0.0260795
154CSNK2A1-0.0166651
155MARK3-0.0164698
156EGFR-0.0136043
157MAP3K7-0.0118344
158PRKG2-0.0114377
159PRKACA-0.0113288
160PRKCA-0.0096963
161PRKCB-0.0083821
162YES1-0.0077946
163PRKCD-0.0050632

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.60577798
2Fatty acid biosynthesis_Homo sapiens_hsa000614.55163233
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.46590456
4Pyruvate metabolism_Homo sapiens_hsa006203.27839501
5Vitamin B6 metabolism_Homo sapiens_hsa007502.93551695
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.89438150
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.88067834
8Linoleic acid metabolism_Homo sapiens_hsa005912.79496903
9Glucagon signaling pathway_Homo sapiens_hsa049222.78795330
10Propanoate metabolism_Homo sapiens_hsa006402.63074138
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.58970875
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54073777
13Allograft rejection_Homo sapiens_hsa053302.45499284
14Autoimmune thyroid disease_Homo sapiens_hsa053202.34392531
15Graft-versus-host disease_Homo sapiens_hsa053322.32186906
16Type I diabetes mellitus_Homo sapiens_hsa049402.20150571
17Viral myocarditis_Homo sapiens_hsa054162.06785247
18Cardiac muscle contraction_Homo sapiens_hsa042601.96473022
19PPAR signaling pathway_Homo sapiens_hsa033201.87412925
20Glycerolipid metabolism_Homo sapiens_hsa005611.82174587
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77038245
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74780716
23Oocyte meiosis_Homo sapiens_hsa041141.69892702
24Basal transcription factors_Homo sapiens_hsa030221.69248399
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.67962512
26Fructose and mannose metabolism_Homo sapiens_hsa000511.66109244
27* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60848504
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59482416
29Amphetamine addiction_Homo sapiens_hsa050311.56375966
30Osteoclast differentiation_Homo sapiens_hsa043801.55752666
31Carbon metabolism_Homo sapiens_hsa012001.54993724
32Fatty acid metabolism_Homo sapiens_hsa012121.54626949
33Fatty acid degradation_Homo sapiens_hsa000711.53916015
34* Antigen processing and presentation_Homo sapiens_hsa046121.52205465
35Dorso-ventral axis formation_Homo sapiens_hsa043201.50146716
36Selenocompound metabolism_Homo sapiens_hsa004501.48127741
37T cell receptor signaling pathway_Homo sapiens_hsa046601.42038603
38Pentose phosphate pathway_Homo sapiens_hsa000301.41472502
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38769265
40Acute myeloid leukemia_Homo sapiens_hsa052211.37573281
41Mineral absorption_Homo sapiens_hsa049781.35761473
42Fat digestion and absorption_Homo sapiens_hsa049751.34747631
43* Influenza A_Homo sapiens_hsa051641.33494155
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.33298288
45Renin secretion_Homo sapiens_hsa049241.29225860
46Ether lipid metabolism_Homo sapiens_hsa005651.27706457
47Leishmaniasis_Homo sapiens_hsa051401.19109473
48Herpes simplex infection_Homo sapiens_hsa051681.17176188
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15646755
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.14984790
51Insulin secretion_Homo sapiens_hsa049111.13718084
52Huntingtons disease_Homo sapiens_hsa050161.13100722
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10893347
54Long-term potentiation_Homo sapiens_hsa047201.09179867
55Primary immunodeficiency_Homo sapiens_hsa053401.07473284
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06782867
57Chemokine signaling pathway_Homo sapiens_hsa040621.02027935
58* MAPK signaling pathway_Homo sapiens_hsa040100.98840402
59* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97643355
60ErbB signaling pathway_Homo sapiens_hsa040120.97144063
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95769779
62Regulation of autophagy_Homo sapiens_hsa041400.93783281
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91848934
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.91204076
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89137247
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.87662454
67Purine metabolism_Homo sapiens_hsa002300.87508950
68Phenylalanine metabolism_Homo sapiens_hsa003600.86088306
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.85420850
70Biosynthesis of amino acids_Homo sapiens_hsa012300.84019066
71Collecting duct acid secretion_Homo sapiens_hsa049660.83798511
72Calcium signaling pathway_Homo sapiens_hsa040200.83472300
73Thyroid hormone synthesis_Homo sapiens_hsa049180.83334877
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83316182
75mTOR signaling pathway_Homo sapiens_hsa041500.82908378
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82326537
77Fanconi anemia pathway_Homo sapiens_hsa034600.82027832
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81905210
79mRNA surveillance pathway_Homo sapiens_hsa030150.81128358
80Gastric acid secretion_Homo sapiens_hsa049710.80057192
81Viral carcinogenesis_Homo sapiens_hsa052030.79078145
82Bile secretion_Homo sapiens_hsa049760.78488077
83Hedgehog signaling pathway_Homo sapiens_hsa043400.77973397
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77384027
85Morphine addiction_Homo sapiens_hsa050320.75201378
86Salivary secretion_Homo sapiens_hsa049700.75119850
87* Measles_Homo sapiens_hsa051620.73338613
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.72803486
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72604454
90Non-small cell lung cancer_Homo sapiens_hsa052230.72591643
91Prolactin signaling pathway_Homo sapiens_hsa049170.71775472
92Arachidonic acid metabolism_Homo sapiens_hsa005900.70844032
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.70121137
94Glutathione metabolism_Homo sapiens_hsa004800.68909875
95AMPK signaling pathway_Homo sapiens_hsa041520.68719814
96Nicotine addiction_Homo sapiens_hsa050330.67529692
97Tuberculosis_Homo sapiens_hsa051520.66630063
98Renin-angiotensin system_Homo sapiens_hsa046140.64928238
99Synaptic vesicle cycle_Homo sapiens_hsa047210.64022709
100VEGF signaling pathway_Homo sapiens_hsa043700.63750161
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63197633
102Pancreatic secretion_Homo sapiens_hsa049720.62416350
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62375680
104Staphylococcus aureus infection_Homo sapiens_hsa051500.61982793
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60652674
106TNF signaling pathway_Homo sapiens_hsa046680.60072087
107Circadian entrainment_Homo sapiens_hsa047130.59143276
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59088298
109Malaria_Homo sapiens_hsa051440.56197938
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54651511
111Choline metabolism in cancer_Homo sapiens_hsa052310.53678088
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.53402311
113Butanoate metabolism_Homo sapiens_hsa006500.52671726
114cAMP signaling pathway_Homo sapiens_hsa040240.52476139
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52365364
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52008638
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.50652397
118Chemical carcinogenesis_Homo sapiens_hsa052040.49580490
119Systemic lupus erythematosus_Homo sapiens_hsa053220.49380732
120* Epstein-Barr virus infection_Homo sapiens_hsa051690.48938032
121* Toxoplasmosis_Homo sapiens_hsa051450.48786084
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48760414
123Inositol phosphate metabolism_Homo sapiens_hsa005620.46662896
124Endometrial cancer_Homo sapiens_hsa052130.46294622
125Protein digestion and absorption_Homo sapiens_hsa049740.46145373
126RNA transport_Homo sapiens_hsa030130.45839013
127ABC transporters_Homo sapiens_hsa020100.45391111
128Cholinergic synapse_Homo sapiens_hsa047250.44097012
129Phagosome_Homo sapiens_hsa041450.43351692
130Oxytocin signaling pathway_Homo sapiens_hsa049210.41799766
131FoxO signaling pathway_Homo sapiens_hsa040680.41316345
132Taste transduction_Homo sapiens_hsa047420.41076299
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40969779
134Serotonergic synapse_Homo sapiens_hsa047260.40250400
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39986422
136* Estrogen signaling pathway_Homo sapiens_hsa049150.39378409
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38002033
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37980136
139* Legionellosis_Homo sapiens_hsa051340.37522800
140Long-term depression_Homo sapiens_hsa047300.36936986
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36452952
142Insulin resistance_Homo sapiens_hsa049310.34473776
143* Endocytosis_Homo sapiens_hsa041440.33843989
144Insulin signaling pathway_Homo sapiens_hsa049100.33116494
145B cell receptor signaling pathway_Homo sapiens_hsa046620.32975139
146Type II diabetes mellitus_Homo sapiens_hsa049300.30880137
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28398613
148HIF-1 signaling pathway_Homo sapiens_hsa040660.28339779
149Alcoholism_Homo sapiens_hsa050340.27687446
150Metabolic pathways_Homo sapiens_hsa011000.27436257
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24565520
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24210111
153Cocaine addiction_Homo sapiens_hsa050300.23162431
154Glutamatergic synapse_Homo sapiens_hsa047240.20997333
155Olfactory transduction_Homo sapiens_hsa047400.20319227
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20251502
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14720549
158Dopaminergic synapse_Homo sapiens_hsa047280.14318926

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »