HSP90B3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.91244856
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.64209042
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04291790
4ATP synthesis coupled proton transport (GO:0015986)4.91297463
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.91297463
6proteasome assembly (GO:0043248)4.91226555
7protein neddylation (GO:0045116)4.48443688
8cytidine metabolic process (GO:0046087)4.39668911
9cytidine catabolic process (GO:0006216)4.39668911
10cytidine deamination (GO:0009972)4.39668911
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.35688569
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.35688569
13signal peptide processing (GO:0006465)4.34058618
14positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.23832072
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20147556
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.20147556
17NADH dehydrogenase complex assembly (GO:0010257)4.20147556
18protein complex biogenesis (GO:0070271)4.18570928
19chaperone-mediated protein transport (GO:0072321)4.03920529
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.99678374
21respiratory chain complex IV assembly (GO:0008535)3.98099912
22regulation of isotype switching to IgG isotypes (GO:0048302)3.91696663
23regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.90417676
24mitochondrial respiratory chain complex assembly (GO:0033108)3.85370380
25pyrimidine ribonucleoside catabolic process (GO:0046133)3.83431329
26regulation of regulatory T cell differentiation (GO:0045589)3.83075531
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81509171
28rRNA modification (GO:0000154)3.79003633
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78835982
30respiratory electron transport chain (GO:0022904)3.67518985
31electron transport chain (GO:0022900)3.66633064
32rRNA methylation (GO:0031167)3.61015470
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.54441978
34cytochrome complex assembly (GO:0017004)3.43689375
35ribosomal small subunit assembly (GO:0000028)3.38941453
36platelet dense granule organization (GO:0060155)3.27131736
37preassembly of GPI anchor in ER membrane (GO:0016254)3.26981927
38GTP biosynthetic process (GO:0006183)3.23420757
39behavioral response to nicotine (GO:0035095)3.22347667
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.22055976
41termination of RNA polymerase III transcription (GO:0006386)3.22055976
42hydrogen ion transmembrane transport (GO:1902600)3.18312447
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17108905
44positive regulation of defense response to virus by host (GO:0002230)3.13814274
45water-soluble vitamin biosynthetic process (GO:0042364)3.10718583
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07130137
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05509059
48regulation of mitochondrial translation (GO:0070129)3.04423956
49regulation of cellular amino acid metabolic process (GO:0006521)3.02317530
50ATP biosynthetic process (GO:0006754)2.99852733
51kynurenine metabolic process (GO:0070189)2.99768194
52proton transport (GO:0015992)2.99451798
53hydrogen transport (GO:0006818)2.95523832
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94744886
55negative regulation of ligase activity (GO:0051352)2.94744886
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93108326
57sequestering of actin monomers (GO:0042989)2.90635311
58pseudouridine synthesis (GO:0001522)2.82067880
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80761346
60mannosylation (GO:0097502)2.80735993
61negative regulation by host of viral transcription (GO:0043922)2.80193848
62retinal cone cell development (GO:0046549)2.79109007
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78970063
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77305304
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77305304
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77305304
67tryptophan catabolic process (GO:0006569)2.75521849
68indole-containing compound catabolic process (GO:0042436)2.75521849
69indolalkylamine catabolic process (GO:0046218)2.75521849
70maturation of SSU-rRNA (GO:0030490)2.72168251
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71793370
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71793370
73protein peptidyl-prolyl isomerization (GO:0000413)2.64512111
74tRNA processing (GO:0008033)2.62919207
75cotranslational protein targeting to membrane (GO:0006613)2.62020489
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.61797422
77regulation of mesoderm development (GO:2000380)2.61630226
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60735894
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.60735894
80regulation of thymocyte apoptotic process (GO:0070243)2.59899990
81regulation of chronic inflammatory response (GO:0002676)2.59462573
82GPI anchor metabolic process (GO:0006505)2.59024527
83ribonucleoside triphosphate biosynthetic process (GO:0009201)2.58800672
84negative regulation of DNA-dependent DNA replication (GO:2000104)2.58048134
85cellular component biogenesis (GO:0044085)2.57557606
86positive regulation of prostaglandin secretion (GO:0032308)2.57280959
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.56467413
88protein targeting to ER (GO:0045047)2.56123527
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52741922
90DNA damage response, detection of DNA damage (GO:0042769)2.51519887
91N-acetylglucosamine metabolic process (GO:0006044)2.51023014
92UTP biosynthetic process (GO:0006228)2.51014658
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50938380
94isotype switching (GO:0045190)2.50938380
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50938380
96protein-cofactor linkage (GO:0018065)2.50462687
97thalamus development (GO:0021794)2.50193980
98translation (GO:0006412)2.49672946
99regulation of T cell receptor signaling pathway (GO:0050856)2.49014192
100ribosomal large subunit biogenesis (GO:0042273)2.48496218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.50655709
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.65419717
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21554919
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.42662101
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02030795
6ZNF274_21170338_ChIP-Seq_K562_Hela2.99495025
7VDR_22108803_ChIP-Seq_LS180_Human2.87172394
8ELK1_19687146_ChIP-ChIP_HELA_Human2.82672329
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.80011902
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55532499
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48329983
12VDR_23849224_ChIP-Seq_CD4+_Human2.45047677
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40827033
14* EWS_26573619_Chip-Seq_HEK293_Human2.30295764
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21393375
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19051485
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17514868
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.16373604
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12730922
20IGF1R_20145208_ChIP-Seq_DFB_Human1.93218460
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90631630
22MYC_18940864_ChIP-ChIP_HL60_Human1.90408880
23FOXP3_21729870_ChIP-Seq_TREG_Human1.89869034
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.88951611
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79198442
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.78517871
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75817350
28FUS_26573619_Chip-Seq_HEK293_Human1.62173774
29P300_19829295_ChIP-Seq_ESCs_Human1.60894785
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.59633276
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57312423
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55247355
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54817678
34NANOG_19829295_ChIP-Seq_ESCs_Human1.47489288
35SOX2_19829295_ChIP-Seq_ESCs_Human1.47489288
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.45162441
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45124081
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44001267
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43147629
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42698935
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42264082
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41507478
43TAF15_26573619_Chip-Seq_HEK293_Human1.39706618
44AR_20517297_ChIP-Seq_VCAP_Human1.37482732
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.36928182
46TP53_22573176_ChIP-Seq_HFKS_Human1.36396321
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28785993
48IRF1_19129219_ChIP-ChIP_H3396_Human1.28401254
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.28231962
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26016758
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23488211
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.23481681
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23381508
54E2F7_22180533_ChIP-Seq_HELA_Human1.22623083
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21385506
56ER_23166858_ChIP-Seq_MCF-7_Human1.21201892
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20021183
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20014494
59CBP_20019798_ChIP-Seq_JUKART_Human1.20014494
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.19453276
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19453276
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14844364
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12988692
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11136625
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08115066
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07444328
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.07185682
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06579714
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06386551
70GATA3_26560356_Chip-Seq_TH2_Human1.05612207
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05049015
72TTF2_22483619_ChIP-Seq_HELA_Human1.04972586
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.04787007
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.03954194
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02434834
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97121607
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97004551
78* TCF4_22108803_ChIP-Seq_LS180_Human0.96566666
79BCAT_22108803_ChIP-Seq_LS180_Human0.96397761
80MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96078957
81DCP1A_22483619_ChIP-Seq_HELA_Human0.95670382
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95494732
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95254716
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.94245469
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92421548
86TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91883529
87NCOR_22424771_ChIP-Seq_293T_Human0.91464246
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91325349
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.91055959
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90329116
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.89809195
92GABP_19822575_ChIP-Seq_HepG2_Human0.89200531
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87043024
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.87017032
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.85585885
96* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85209913
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84429106
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84244562
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83881072
100* PRDM14_20953172_ChIP-Seq_ESCs_Human0.82930838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis4.10905783
2MP0005671_abnormal_response_to3.86066971
3MP0006054_spinal_hemorrhage3.40138336
4MP0009379_abnormal_foot_pigmentation2.77334928
5MP0009697_abnormal_copulation2.68870777
6MP0000569_abnormal_digit_pigmentation2.65792801
7MP0001835_abnormal_antigen_presentation2.59755333
8MP0003786_premature_aging2.48889905
9MP0002102_abnormal_ear_morphology2.25016632
10MP0004147_increased_porphyrin_level2.12206531
11MP0005253_abnormal_eye_physiology2.11248523
12MP0005551_abnormal_eye_electrophysiolog2.01851690
13MP0001293_anophthalmia1.92864288
14MP0006292_abnormal_olfactory_placode1.89720450
15MP0002938_white_spotting1.86920493
16MP0001873_stomach_inflammation1.86637949
17MP0005408_hypopigmentation1.85561146
18MP0005084_abnormal_gallbladder_morpholo1.73767690
19MP0003252_abnormal_bile_duct1.71687547
20MP0002837_dystrophic_cardiac_calcinosis1.70970496
21MP0005174_abnormal_tail_pigmentation1.68550624
22MP0003119_abnormal_digestive_system1.66299017
23MP0005645_abnormal_hypothalamus_physiol1.66137210
24MP0003718_maternal_effect1.65988584
25MP0003195_calcinosis1.58654330
26MP0001529_abnormal_vocalization1.51477014
27MP0000372_irregular_coat_pigmentation1.49436294
28MP0002396_abnormal_hematopoietic_system1.42181132
29MP0008872_abnormal_physiological_respon1.40582017
30MP0002006_tumorigenesis1.39158039
31MP0001485_abnormal_pinna_reflex1.36161387
32MP0005646_abnormal_pituitary_gland1.32942175
33MP0008877_abnormal_DNA_methylation1.31676371
34MP0002933_joint_inflammation1.31547198
35MP0002148_abnormal_hypersensitivity_rea1.30260014
36MP0002277_abnormal_respiratory_mucosa1.27205092
37MP0006036_abnormal_mitochondrial_physio1.26108834
38MP0008789_abnormal_olfactory_epithelium1.25938378
39MP0004742_abnormal_vestibular_system1.23866897
40MP0002234_abnormal_pharynx_morphology1.18537356
41MP0003186_abnormal_redox_activity1.17305682
42MP0008995_early_reproductive_senescence1.15728990
43MP0008875_abnormal_xenobiotic_pharmacok1.15726984
44MP0003011_delayed_dark_adaptation1.15556874
45MP0003283_abnormal_digestive_organ1.13589833
46MP0003890_abnormal_embryonic-extraembry1.12148163
47MP0001346_abnormal_lacrimal_gland1.11261117
48MP0001764_abnormal_homeostasis1.10901066
49MP0000427_abnormal_hair_cycle1.08806525
50MP0000631_abnormal_neuroendocrine_gland1.08077559
51MP0005391_vision/eye_phenotype1.07996963
52MP0004885_abnormal_endolymph1.07640121
53MP0004215_abnormal_myocardial_fiber1.06565562
54MP0003693_abnormal_embryo_hatching1.06110804
55MP0002160_abnormal_reproductive_system1.05848047
56MP0005389_reproductive_system_phenotype1.01398154
57MP0004142_abnormal_muscle_tone0.98603203
58MP0002254_reproductive_system_inflammat0.95936093
59MP0003137_abnormal_impulse_conducting0.94252402
60MP0005332_abnormal_amino_acid0.93819991
61MP0002876_abnormal_thyroid_physiology0.92478600
62MP0001800_abnormal_humoral_immune0.92425111
63MP0002233_abnormal_nose_morphology0.90823866
64MP0001905_abnormal_dopamine_level0.89928506
65MP0001756_abnormal_urination0.86830878
66MP0010094_abnormal_chromosome_stability0.86708242
67MP0010030_abnormal_orbit_morphology0.86295070
68MP0002095_abnormal_skin_pigmentation0.86274650
69MP0003724_increased_susceptibility_to0.85822191
70MP0005195_abnormal_posterior_eye0.85332434
71MP0004133_heterotaxia0.83972067
72MP0003937_abnormal_limbs/digits/tail_de0.82089181
73MP0002163_abnormal_gland_morphology0.82050530
74MP0002751_abnormal_autonomic_nervous0.80618505
75MP0002928_abnormal_bile_duct0.80363703
76MP0008058_abnormal_DNA_repair0.80293360
77MP0004782_abnormal_surfactant_physiolog0.77664428
78MP0000566_synostosis0.77162674
79MP0000685_abnormal_immune_system0.77042018
80MP0001881_abnormal_mammary_gland0.76321905
81MP0005360_urolithiasis0.75436426
82MP0002166_altered_tumor_susceptibility0.73875046
83MP0009764_decreased_sensitivity_to0.70900495
84MP0001853_heart_inflammation0.69240420
85MP0002210_abnormal_sex_determination0.68041210
86MP0010307_abnormal_tumor_latency0.67777881
87MP0005085_abnormal_gallbladder_physiolo0.67220738
88MP0002136_abnormal_kidney_physiology0.67079576
89MP0001845_abnormal_inflammatory_respons0.66860286
90MP0001819_abnormal_immune_cell0.66214195
91MP0002272_abnormal_nervous_system0.66177259
92MP0002452_abnormal_antigen_presenting0.65583402
93MP0001119_abnormal_female_reproductive0.65492126
94MP0006035_abnormal_mitochondrial_morpho0.65474096
95MP0009785_altered_susceptibility_to0.65318848
96MP0005000_abnormal_immune_tolerance0.64438654
97MP0002405_respiratory_system_inflammati0.64374231
98MP0000026_abnormal_inner_ear0.63692907
99MP0002723_abnormal_immune_serum0.63579077
100MP0001790_abnormal_immune_system0.63231609

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.52087397
2Mitochondrial inheritance (HP:0001427)4.01452943
3Hepatocellular necrosis (HP:0001404)3.74308779
4IgG deficiency (HP:0004315)3.70030113
5Increased CSF lactate (HP:0002490)3.61567401
6Acute necrotizing encephalopathy (HP:0006965)3.52298372
7Increased hepatocellular lipid droplets (HP:0006565)3.48099305
8Hepatic necrosis (HP:0002605)3.42816206
9Posterior subcapsular cataract (HP:0007787)3.36444830
10Lipid accumulation in hepatocytes (HP:0006561)3.23877423
11Congenital stationary night blindness (HP:0007642)3.19453763
12Abnormal mitochondria in muscle tissue (HP:0008316)3.08007314
133-Methylglutaconic aciduria (HP:0003535)3.07812480
14Acute encephalopathy (HP:0006846)3.06375066
15Abnormal number of erythroid precursors (HP:0012131)3.04773848
16Pancreatic cysts (HP:0001737)3.02916393
17Chronic diarrhea (HP:0002028)2.98583893
18Abnormality of midbrain morphology (HP:0002418)2.97753599
19Molar tooth sign on MRI (HP:0002419)2.97753599
20Nephronophthisis (HP:0000090)2.89171315
21Abnormality of B cell number (HP:0010975)2.89141313
22Abnormality of T cell physiology (HP:0011840)2.87440335
23Hypoproteinemia (HP:0003075)2.85027292
24Stomatitis (HP:0010280)2.84100977
25Renal Fanconi syndrome (HP:0001994)2.83067270
26Type I transferrin isoform profile (HP:0003642)2.78634769
27Pancreatic fibrosis (HP:0100732)2.76765680
28Progressive macrocephaly (HP:0004481)2.76380537
29Constricted visual fields (HP:0001133)2.75548709
30Abnormality of cells of the erythroid lineage (HP:0012130)2.71630684
31Hypoplasia of the pons (HP:0012110)2.68808225
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68392760
33Abnormality of the pons (HP:0007361)2.67471545
34IgM deficiency (HP:0002850)2.65387795
35Methylmalonic acidemia (HP:0002912)2.62458734
36Abnormal rod and cone electroretinograms (HP:0008323)2.52178725
37Increased serum lactate (HP:0002151)2.48881824
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46685714
39Exertional dyspnea (HP:0002875)2.46608273
40Abolished electroretinogram (ERG) (HP:0000550)2.46580615
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45291686
42Abnormal protein N-linked glycosylation (HP:0012347)2.45291686
43Abnormal protein glycosylation (HP:0012346)2.45291686
44Abnormal glycosylation (HP:0012345)2.45291686
45B lymphocytopenia (HP:0010976)2.44982087
46True hermaphroditism (HP:0010459)2.44211489
47Abnormality of T cells (HP:0002843)2.43573926
48Increased IgM level (HP:0003496)2.41562588
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41063189
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41063189
51Abnormal biliary tract physiology (HP:0012439)2.40625456
52Bile duct proliferation (HP:0001408)2.40625456
53Cerebral edema (HP:0002181)2.39486988
54Abnormality of the renal medulla (HP:0100957)2.39413616
55Severe combined immunodeficiency (HP:0004430)2.35496743
56Methylmalonic aciduria (HP:0012120)2.33530394
57Abnormality of the renal cortex (HP:0011035)2.28895969
58IgA deficiency (HP:0002720)2.28237015
59Increased intramyocellular lipid droplets (HP:0012240)2.27005863
60Lactic acidosis (HP:0003128)2.26865851
61Abnormality of alanine metabolism (HP:0010916)2.24649820
62Hyperalaninemia (HP:0003348)2.24649820
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24649820
64Hyperglycinemia (HP:0002154)2.14758646
65Abnormality of the prostate (HP:0008775)2.13673451
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12485538
67Aplasia/hypoplasia of the uterus (HP:0008684)2.12129776
68Optic disc pallor (HP:0000543)2.06944666
69Pendular nystagmus (HP:0012043)2.06699989
70Colon cancer (HP:0003003)2.05534694
71Hemoptysis (HP:0002105)2.05051846
72Renal cortical cysts (HP:0000803)2.02721013
73Synostosis involving the elbow (HP:0003938)1.99788281
74Humeroradial synostosis (HP:0003041)1.99788281
75Hypoplasia of the uterus (HP:0000013)1.99093897
76Aplastic anemia (HP:0001915)1.96054946
77Abnormality of urine glucose concentration (HP:0011016)1.95700751
78Glycosuria (HP:0003076)1.95700751
79Abnormal albumin level (HP:0012116)1.95502372
80Hypoalbuminemia (HP:0003073)1.95502372
81Cerebral palsy (HP:0100021)1.93139689
82Elevated erythrocyte sedimentation rate (HP:0003565)1.92977455
83Abnormality of renal resorption (HP:0011038)1.91250953
84Lethargy (HP:0001254)1.90749692
85Respiratory failure (HP:0002878)1.90452385
86Abnormality of T cell number (HP:0011839)1.89227174
87Hydroxyprolinuria (HP:0003080)1.88838117
88Abnormality of proline metabolism (HP:0010907)1.88838117
89Dyschromatopsia (HP:0007641)1.88001472
90Short hallux (HP:0010109)1.87460679
91Abnormal spermatogenesis (HP:0008669)1.85959074
92Tubular atrophy (HP:0000092)1.85944749
93Chronic hepatic failure (HP:0100626)1.83880004
94Absent/shortened dynein arms (HP:0200106)1.83098075
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.83098075
96Abnormality of serum amino acid levels (HP:0003112)1.78773937
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77981701
98Cystic liver disease (HP:0006706)1.77780126
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77756628
100Type 2 muscle fiber atrophy (HP:0003554)1.75924774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.21075759
2TXK4.17462032
3NUAK12.90393658
4TLK12.51377729
5ACVR1B2.51113741
6MST42.48809007
7WNK32.43516787
8TNIK2.42267360
9ADRBK22.36555814
10TRIM282.34695475
11TAF12.33919692
12BMPR1B2.31641030
13VRK12.21199092
14TAOK32.08003086
15GRK12.05053470
16ZAK2.03405613
17NME11.92687574
18EIF2AK31.80926985
19BCKDK1.77104540
20STK161.73769243
21MAP4K21.64256283
22NEK11.57253134
23TIE11.56915853
24SRPK11.54075512
25MAP3K121.52416381
26INSRR1.43377986
27STK391.35682698
28PLK31.34106066
29BUB11.33033607
30OXSR11.29051759
31BRSK21.16587971
32DAPK11.14999803
33WNK41.12451454
34MKNK11.10529146
35EPHA31.09743613
36TEC1.09044164
37FRK1.06384402
38MAPKAPK31.03209025
39KDR1.00660274
40CDC70.98963282
41ITK0.95288590
42NLK0.93179764
43PINK10.92715962
44MKNK20.90588575
45MAP3K130.86728039
46CSNK1G10.86569592
47PLK40.85839656
48GRK50.84289122
49IKBKB0.82804455
50PDK20.82764859
51MYLK0.81149667
52BCR0.79410458
53TGFBR10.79038395
54CSNK1G30.76061889
55ADRBK10.75695092
56CAMKK20.75125083
57MAP3K90.73065593
58DYRK20.69574869
59LIMK10.69459327
60CSK0.66631771
61TSSK60.65975326
62FLT30.65941987
63EIF2AK20.65284963
64CSNK1A1L0.64526424
65CSNK1G20.61451851
66NEK90.57767400
67PRKCE0.57081796
68PRKCQ0.53998876
69MAP3K140.53460092
70CDK190.51699758
71PHKG10.51203027
72PHKG20.51203027
73PLK20.48653527
74NEK20.48427158
75MELK0.48356554
76PLK10.46722748
77BTK0.43047838
78SCYL20.42167125
79CSNK1A10.42132285
80IRAK10.41425989
81ERBB40.40892749
82PRKCG0.39963932
83CSNK2A10.39946174
84FES0.39528922
85EPHB20.39082366
86ALK0.38111210
87PTK2B0.37762363
88CAMK2D0.35803496
89TTK0.35441447
90LYN0.35387199
91LATS10.34767873
92CSNK2A20.34054374
93MAP2K20.33684652
94ATR0.33237179
95GRK70.32917384
96AURKB0.29989668
97KIT0.29470310
98MOS0.29304877
99PBK0.29284729
100ILK0.29136505

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28598121
2Oxidative phosphorylation_Homo sapiens_hsa001903.58521520
3Protein export_Homo sapiens_hsa030603.24491033
4Parkinsons disease_Homo sapiens_hsa050122.94489347
5Ribosome_Homo sapiens_hsa030102.83042631
6Asthma_Homo sapiens_hsa053102.51742201
7RNA polymerase_Homo sapiens_hsa030202.47596355
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37079345
9Allograft rejection_Homo sapiens_hsa053302.24898114
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.22576597
11Autoimmune thyroid disease_Homo sapiens_hsa053202.13436601
12Huntingtons disease_Homo sapiens_hsa050162.04467513
13Phototransduction_Homo sapiens_hsa047441.96485865
14Alzheimers disease_Homo sapiens_hsa050101.95554767
15Primary immunodeficiency_Homo sapiens_hsa053401.89318242
16Graft-versus-host disease_Homo sapiens_hsa053321.83811008
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83367809
18Homologous recombination_Homo sapiens_hsa034401.76739760
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76729746
20Nitrogen metabolism_Homo sapiens_hsa009101.75107090
21Basal transcription factors_Homo sapiens_hsa030221.72984276
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69923401
23Type I diabetes mellitus_Homo sapiens_hsa049401.62116000
24Cardiac muscle contraction_Homo sapiens_hsa042601.61834967
25Rheumatoid arthritis_Homo sapiens_hsa053231.60375938
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59516417
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52044280
28RNA degradation_Homo sapiens_hsa030181.44138507
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41527885
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38306695
31Propanoate metabolism_Homo sapiens_hsa006401.25632149
32Sulfur metabolism_Homo sapiens_hsa009201.23085619
33Pyrimidine metabolism_Homo sapiens_hsa002401.23022561
34Antigen processing and presentation_Homo sapiens_hsa046121.22529638
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22522962
36Linoleic acid metabolism_Homo sapiens_hsa005911.18498159
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13782929
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07370740
39One carbon pool by folate_Homo sapiens_hsa006701.06742429
40DNA replication_Homo sapiens_hsa030301.06113894
41Purine metabolism_Homo sapiens_hsa002300.99482443
42Spliceosome_Homo sapiens_hsa030400.97099283
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95313212
44Fanconi anemia pathway_Homo sapiens_hsa034600.95105926
45Mismatch repair_Homo sapiens_hsa034300.94534490
46Nucleotide excision repair_Homo sapiens_hsa034200.93726377
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92316545
48Regulation of autophagy_Homo sapiens_hsa041400.91072594
49Tryptophan metabolism_Homo sapiens_hsa003800.89617556
50Peroxisome_Homo sapiens_hsa041460.88808486
51N-Glycan biosynthesis_Homo sapiens_hsa005100.88153385
52Folate biosynthesis_Homo sapiens_hsa007900.86510681
53RNA transport_Homo sapiens_hsa030130.82760763
54Steroid biosynthesis_Homo sapiens_hsa001000.81668987
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.79519620
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78614694
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76154007
58Caffeine metabolism_Homo sapiens_hsa002320.74161328
59Collecting duct acid secretion_Homo sapiens_hsa049660.73180489
60Chemical carcinogenesis_Homo sapiens_hsa052040.70795182
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68278419
62Glutathione metabolism_Homo sapiens_hsa004800.67879456
63Butanoate metabolism_Homo sapiens_hsa006500.65814109
64Metabolic pathways_Homo sapiens_hsa011000.65451565
65Hematopoietic cell lineage_Homo sapiens_hsa046400.65081857
66Viral myocarditis_Homo sapiens_hsa054160.64618074
67Ether lipid metabolism_Homo sapiens_hsa005650.60443002
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59184074
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.58410267
70Fatty acid elongation_Homo sapiens_hsa000620.57749002
71Vitamin digestion and absorption_Homo sapiens_hsa049770.57482941
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57256246
73T cell receptor signaling pathway_Homo sapiens_hsa046600.57171927
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56704859
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53668746
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52866265
77Selenocompound metabolism_Homo sapiens_hsa004500.52652941
78Retinol metabolism_Homo sapiens_hsa008300.45973435
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45747090
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39053788
81Olfactory transduction_Homo sapiens_hsa047400.38913305
82Fat digestion and absorption_Homo sapiens_hsa049750.37728595
83Arachidonic acid metabolism_Homo sapiens_hsa005900.35762603
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34792503
85TGF-beta signaling pathway_Homo sapiens_hsa043500.34774276
86Pyruvate metabolism_Homo sapiens_hsa006200.32980136
87Mineral absorption_Homo sapiens_hsa049780.32624566
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.32187233
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31479886
90Basal cell carcinoma_Homo sapiens_hsa052170.29439406
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.29303609
92Systemic lupus erythematosus_Homo sapiens_hsa053220.28266041
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.27651562
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27170539
95Hedgehog signaling pathway_Homo sapiens_hsa043400.25261197
96Fatty acid degradation_Homo sapiens_hsa000710.24699457
97Epstein-Barr virus infection_Homo sapiens_hsa051690.23837335
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23576654
99Nicotine addiction_Homo sapiens_hsa050330.23044663
100Base excision repair_Homo sapiens_hsa034100.23015230

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