HSP90AB3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.88490867
2proteasome assembly (GO:0043248)4.95275607
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.78813388
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64825771
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56949047
6ATP synthesis coupled proton transport (GO:0015986)4.56949047
7protein neddylation (GO:0045116)4.42161312
8protein complex biogenesis (GO:0070271)4.40422444
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37513990
10water-soluble vitamin biosynthetic process (GO:0042364)4.35955335
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19810049
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.19810049
13NADH dehydrogenase complex assembly (GO:0010257)4.19810049
14mitochondrial respiratory chain complex assembly (GO:0033108)4.15177210
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.96284732
16chaperone-mediated protein transport (GO:0072321)3.95234613
17rRNA modification (GO:0000154)3.94700218
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.87836778
19respiratory chain complex IV assembly (GO:0008535)3.82284782
20termination of RNA polymerase III transcription (GO:0006386)3.78340613
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.78340613
22regulation of cellular amino acid metabolic process (GO:0006521)3.72470555
23electron transport chain (GO:0022900)3.71443903
24respiratory electron transport chain (GO:0022904)3.70346670
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59233005
26cullin deneddylation (GO:0010388)3.55032048
27maturation of 5.8S rRNA (GO:0000460)3.53413211
28cytochrome complex assembly (GO:0017004)3.51962573
29mannosylation (GO:0097502)3.45338005
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44564854
31protein deneddylation (GO:0000338)3.44084058
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44052432
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42306240
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37086122
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37086122
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37086122
37rRNA methylation (GO:0031167)3.33539206
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32997433
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32997433
40platelet dense granule organization (GO:0060155)3.30132748
41pseudouridine synthesis (GO:0001522)3.29508445
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29154946
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25374830
44protein-cofactor linkage (GO:0018065)3.24809185
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.22721157
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21004457
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21004457
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20893905
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.20893905
50negative regulation of ligase activity (GO:0051352)3.19918387
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19918387
52cytidine deamination (GO:0009972)3.15317574
53cytidine metabolic process (GO:0046087)3.15317574
54cytidine catabolic process (GO:0006216)3.15317574
55GTP biosynthetic process (GO:0006183)3.09543709
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98163983
57preassembly of GPI anchor in ER membrane (GO:0016254)2.97693866
58peptidyl-histidine modification (GO:0018202)2.97310140
59negative regulation of telomere maintenance (GO:0032205)2.95887384
60ribosome assembly (GO:0042255)2.94740430
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94635038
62tRNA processing (GO:0008033)2.92861832
63DNA damage response, detection of DNA damage (GO:0042769)2.92209206
64purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89318105
65positive regulation of ligase activity (GO:0051351)2.86655783
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85547372
67protein targeting to mitochondrion (GO:0006626)2.85484614
68DNA double-strand break processing (GO:0000729)2.84961939
69inner mitochondrial membrane organization (GO:0007007)2.84538829
70axoneme assembly (GO:0035082)2.84136939
71behavioral response to nicotine (GO:0035095)2.82041579
72establishment of protein localization to mitochondrion (GO:0072655)2.81938968
73hydrogen ion transmembrane transport (GO:1902600)2.81708709
74histone mRNA metabolic process (GO:0008334)2.79214210
75ATP biosynthetic process (GO:0006754)2.77969582
76GPI anchor metabolic process (GO:0006505)2.77647435
77retinal cone cell development (GO:0046549)2.77559909
78ubiquinone biosynthetic process (GO:0006744)2.75042872
79response to pheromone (GO:0019236)2.74737674
80ubiquinone metabolic process (GO:0006743)2.74301890
81proton transport (GO:0015992)2.71434840
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71259982
83protein localization to mitochondrion (GO:0070585)2.71069537
84base-excision repair, AP site formation (GO:0006285)2.70667278
85regulation of cellular amine metabolic process (GO:0033238)2.69653589
86DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.69534884
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68837428
88isotype switching (GO:0045190)2.68837428
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68837428
90spliceosomal snRNP assembly (GO:0000387)2.67955941
91hydrogen transport (GO:0006818)2.67760593
92intracellular protein transmembrane import (GO:0044743)2.65810935
93rRNA processing (GO:0006364)2.64860683
94regulation of mitochondrial translation (GO:0070129)2.62425638
95rRNA metabolic process (GO:0016072)2.61642740
96positive regulation of cell cycle arrest (GO:0071158)2.59867210
97tRNA metabolic process (GO:0006399)2.59707415
98fucose catabolic process (GO:0019317)2.57635738
99L-fucose metabolic process (GO:0042354)2.57635738
100L-fucose catabolic process (GO:0042355)2.57635738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47026188
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.23062778
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.64526192
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22526679
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20383865
6ZNF274_21170338_ChIP-Seq_K562_Hela2.98929395
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98082193
8VDR_22108803_ChIP-Seq_LS180_Human2.96355858
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94820267
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76160467
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71977595
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.60894572
13VDR_23849224_ChIP-Seq_CD4+_Human2.59735750
14ELK1_19687146_ChIP-ChIP_HELA_Human2.46196275
15IGF1R_20145208_ChIP-Seq_DFB_Human2.23301201
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.16186611
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14311805
18FOXP3_21729870_ChIP-Seq_TREG_Human2.13689719
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13237728
20EWS_26573619_Chip-Seq_HEK293_Human2.09050707
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.07939185
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07523100
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05408395
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97690907
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97189644
26MYC_18940864_ChIP-ChIP_HL60_Human1.80471784
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.75160205
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74990233
29FUS_26573619_Chip-Seq_HEK293_Human1.70030991
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65459540
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62499453
32TP53_22573176_ChIP-Seq_HFKS_Human1.58962679
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.56772981
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54576912
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53869030
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50805903
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50546587
38TAF15_26573619_Chip-Seq_HEK293_Human1.48390901
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47792574
40P300_19829295_ChIP-Seq_ESCs_Human1.46394217
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42052326
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39860238
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37622500
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32582616
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.32582616
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30892330
47DCP1A_22483619_ChIP-Seq_HELA_Human1.30664372
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30386033
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.30310482
50GABP_19822575_ChIP-Seq_HepG2_Human1.28990333
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28104458
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27509673
53ER_23166858_ChIP-Seq_MCF-7_Human1.25449525
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25415649
55TTF2_22483619_ChIP-Seq_HELA_Human1.25264709
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24292436
57NANOG_19829295_ChIP-Seq_ESCs_Human1.24215339
58SOX2_19829295_ChIP-Seq_ESCs_Human1.24215339
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21239803
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17774179
61AR_20517297_ChIP-Seq_VCAP_Human1.17456578
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.15970969
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14259387
64GBX2_23144817_ChIP-Seq_PC3_Human1.13800526
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12948269
66CBP_20019798_ChIP-Seq_JUKART_Human1.12094697
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12094697
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10686805
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09323183
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08615690
71NCOR_22424771_ChIP-Seq_293T_Human1.03554346
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.03339479
73IRF1_19129219_ChIP-ChIP_H3396_Human1.03326367
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.02781621
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.02727758
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02698583
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02529811
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02053771
79E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98831598
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98130298
81HTT_18923047_ChIP-ChIP_STHdh_Human0.97651095
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96662110
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96400763
84ERG_20517297_ChIP-Seq_VCAP_Human0.96152774
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95847900
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95644898
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92587644
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92334356
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.91872729
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91755421
91GATA3_26560356_Chip-Seq_TH2_Human0.91167208
92RBPJ_21746931_ChIP-Seq_IB4_Human0.90958897
93BCAT_22108803_ChIP-Seq_LS180_Human0.90840526
94TCF4_22108803_ChIP-Seq_LS180_Human0.90646729
95HOXB7_26014856_ChIP-Seq_BT474_Human0.89469075
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88594326
97PHF8_20622853_ChIP-Seq_HELA_Human0.87033892
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.86771357
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86619860
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.85051231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology2.91496396
2MP0008877_abnormal_DNA_methylation2.85696424
3MP0003195_calcinosis2.75468763
4MP0006072_abnormal_retinal_apoptosis2.65448922
5MP0008058_abnormal_DNA_repair2.28551983
6MP0003786_premature_aging2.24238678
7MP0000372_irregular_coat_pigmentation2.19648521
8MP0005645_abnormal_hypothalamus_physiol2.17177143
9MP0005084_abnormal_gallbladder_morpholo2.08657712
10MP0003011_delayed_dark_adaptation2.06897487
11MP0002837_dystrophic_cardiac_calcinosis2.04658916
12MP0008872_abnormal_physiological_respon2.03671621
13MP0004147_increased_porphyrin_level2.02403684
14MP0008875_abnormal_xenobiotic_pharmacok2.02213945
15MP0005646_abnormal_pituitary_gland2.01245427
16MP0005551_abnormal_eye_electrophysiolog1.95252362
17MP0001529_abnormal_vocalization1.93166795
18MP0005671_abnormal_response_to1.91666270
19MP0006292_abnormal_olfactory_placode1.90518697
20MP0005253_abnormal_eye_physiology1.89507316
21MP0001968_abnormal_touch/_nociception1.86102210
22MP0003718_maternal_effect1.85687400
23MP0002163_abnormal_gland_morphology1.83842904
24MP0002736_abnormal_nociception_after1.78786802
25MP0003787_abnormal_imprinting1.78761387
26MP0001984_abnormal_olfaction1.65543313
27MP0004145_abnormal_muscle_electrophysio1.65361417
28MP0003806_abnormal_nucleotide_metabolis1.63556260
29MP0002876_abnormal_thyroid_physiology1.62459094
30MP0005379_endocrine/exocrine_gland_phen1.57074896
31MP0002277_abnormal_respiratory_mucosa1.56762782
32MP0003646_muscle_fatigue1.55409609
33MP0005075_abnormal_melanosome_morpholog1.53652207
34MP0002138_abnormal_hepatobiliary_system1.53524266
35MP0006276_abnormal_autonomic_nervous1.51703247
36MP0006036_abnormal_mitochondrial_physio1.45455533
37MP0004142_abnormal_muscle_tone1.43460328
38MP0002160_abnormal_reproductive_system1.40946199
39MP0001905_abnormal_dopamine_level1.37336630
40MP0008995_early_reproductive_senescence1.37025480
41MP0001986_abnormal_taste_sensitivity1.36476056
42MP0005389_reproductive_system_phenotype1.33480741
43MP0006035_abnormal_mitochondrial_morpho1.32067460
44MP0003693_abnormal_embryo_hatching1.27066601
45MP0003880_abnormal_central_pattern1.26171497
46MP0001835_abnormal_antigen_presentation1.23208062
47MP0010094_abnormal_chromosome_stability1.22657187
48MP0009745_abnormal_behavioral_response1.21159896
49MP0000631_abnormal_neuroendocrine_gland1.19460726
50MP0002272_abnormal_nervous_system1.18746257
51MP0009046_muscle_twitch1.18486103
52MP0003121_genomic_imprinting1.18080081
53MP0003186_abnormal_redox_activity1.17449679
54MP0005332_abnormal_amino_acid1.16259936
55MP0009697_abnormal_copulation1.14402043
56MP0008007_abnormal_cellular_replicative1.12244272
57MP0003567_abnormal_fetal_cardiomyocyte1.09259671
58MP0004957_abnormal_blastocyst_morpholog1.08242698
59MP0002638_abnormal_pupillary_reflex1.04655735
60MP0001919_abnormal_reproductive_system1.04281817
61MP0002938_white_spotting1.01811378
62MP0002751_abnormal_autonomic_nervous1.01711284
63MP0005410_abnormal_fertilization1.01320416
64MP0001188_hyperpigmentation1.00500801
65MP0001501_abnormal_sleep_pattern0.97609037
66MP0001764_abnormal_homeostasis0.96492856
67MP0005636_abnormal_mineral_homeostasis0.96332043
68MP0004885_abnormal_endolymph0.95442619
69MP0001486_abnormal_startle_reflex0.94264380
70MP0008789_abnormal_olfactory_epithelium0.92623306
71MP0010386_abnormal_urinary_bladder0.90487257
72MP0004043_abnormal_pH_regulation0.89279590
73MP0009785_altered_susceptibility_to0.87373797
74MP0001873_stomach_inflammation0.86493544
75MP0001929_abnormal_gametogenesis0.86238050
76MP0002693_abnormal_pancreas_physiology0.86085127
77MP0002653_abnormal_ependyma_morphology0.86045359
78MP0003122_maternal_imprinting0.83889488
79MP0002210_abnormal_sex_determination0.82670820
80MP0004215_abnormal_myocardial_fiber0.81026753
81MP0003878_abnormal_ear_physiology0.79894086
82MP0005377_hearing/vestibular/ear_phenot0.79894086
83MP0001293_anophthalmia0.79481982
84MP0002733_abnormal_thermal_nociception0.79018690
85MP0004742_abnormal_vestibular_system0.78674920
86MP0000653_abnormal_sex_gland0.78207399
87MP0002006_tumorigenesis0.77774727
88MP0001485_abnormal_pinna_reflex0.77353318
89MP0002557_abnormal_social/conspecific_i0.77027427
90MP0001119_abnormal_female_reproductive0.76044484
91MP0005085_abnormal_gallbladder_physiolo0.75936052
92MP0003137_abnormal_impulse_conducting0.74936273
93MP0005167_abnormal_blood-brain_barrier0.73850225
94MP0009333_abnormal_splenocyte_physiolog0.72804642
95MP0001970_abnormal_pain_threshold0.71938026
96MP0002234_abnormal_pharynx_morphology0.70795707
97MP0002148_abnormal_hypersensitivity_rea0.69710140
98MP0002909_abnormal_adrenal_gland0.69391506
99MP0002254_reproductive_system_inflammat0.69282062
100MP0003698_abnormal_male_reproductive0.68616334

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87501905
2Mitochondrial inheritance (HP:0001427)4.30636294
3Abnormal mitochondria in muscle tissue (HP:0008316)4.27141688
4Progressive macrocephaly (HP:0004481)4.23181028
5Acute encephalopathy (HP:0006846)4.22678503
6Increased CSF lactate (HP:0002490)4.07587787
7Hepatocellular necrosis (HP:0001404)3.83301020
8Hepatic necrosis (HP:0002605)3.54885720
9Increased hepatocellular lipid droplets (HP:0006565)3.48620057
10Pancreatic cysts (HP:0001737)3.34928468
11Lipid accumulation in hepatocytes (HP:0006561)3.31017841
123-Methylglutaconic aciduria (HP:0003535)3.19682760
13Cerebral edema (HP:0002181)3.14055741
14Pancreatic fibrosis (HP:0100732)2.99654091
15Congenital stationary night blindness (HP:0007642)2.98402936
16Abnormality of midbrain morphology (HP:0002418)2.95698633
17Molar tooth sign on MRI (HP:0002419)2.95698633
18Methylmalonic acidemia (HP:0002912)2.91691907
19Renal Fanconi syndrome (HP:0001994)2.88310767
20Increased serum lactate (HP:0002151)2.84304434
21True hermaphroditism (HP:0010459)2.78897566
22Optic disc pallor (HP:0000543)2.77480114
23Nephronophthisis (HP:0000090)2.69971452
24Lactic acidosis (HP:0003128)2.58334005
25Hyperglycinemia (HP:0002154)2.57538116
26Abolished electroretinogram (ERG) (HP:0000550)2.57024835
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53880879
28Methylmalonic aciduria (HP:0012120)2.52254637
29Respiratory failure (HP:0002878)2.47475437
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43192803
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41136446
32Abnormality of the renal cortex (HP:0011035)2.38100793
33Type II lissencephaly (HP:0007260)2.36747788
34Abnormal rod and cone electroretinograms (HP:0008323)2.36438678
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32335199
36Lethargy (HP:0001254)2.31588070
37Abnormality of the labia minora (HP:0012880)2.30234567
38Abnormality of the renal medulla (HP:0100957)2.29693356
39Absent/shortened dynein arms (HP:0200106)2.27993278
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.27993278
41Exertional dyspnea (HP:0002875)2.26610737
42Leukodystrophy (HP:0002415)2.25750844
43Aplastic anemia (HP:0001915)2.25058777
44Exercise intolerance (HP:0003546)2.24704322
45Increased intramyocellular lipid droplets (HP:0012240)2.24225089
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24193842
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24193842
48Aplasia/hypoplasia of the uterus (HP:0008684)2.23359300
49Type I transferrin isoform profile (HP:0003642)2.23296801
50Renal cortical cysts (HP:0000803)2.22707692
51Pendular nystagmus (HP:0012043)2.20104862
52IgG deficiency (HP:0004315)2.18526113
53Hypoproteinemia (HP:0003075)2.16367252
54Congenital, generalized hypertrichosis (HP:0004540)2.12776182
55Abnormality of alanine metabolism (HP:0010916)2.11998788
56Hyperalaninemia (HP:0003348)2.11998788
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11998788
58Hypothermia (HP:0002045)2.10528055
59Attenuation of retinal blood vessels (HP:0007843)2.10204570
60Decreased central vision (HP:0007663)2.09463435
61Abnormal respiratory epithelium morphology (HP:0012253)2.07849154
62Abnormal respiratory motile cilium morphology (HP:0005938)2.07849154
63Abnormal protein glycosylation (HP:0012346)2.05183422
64Abnormal glycosylation (HP:0012345)2.05183422
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05183422
66Abnormal protein N-linked glycosylation (HP:0012347)2.05183422
67Medial flaring of the eyebrow (HP:0010747)2.03036337
68Abnormal drinking behavior (HP:0030082)2.02930483
69Polydipsia (HP:0001959)2.02930483
70Constricted visual fields (HP:0001133)2.02104249
71Stomatitis (HP:0010280)2.02043460
72CNS demyelination (HP:0007305)1.99435994
73Abnormality of serum amino acid levels (HP:0003112)1.97971794
74Chronic hepatic failure (HP:0100626)1.97750574
75Abnormality of urine glucose concentration (HP:0011016)1.97292197
76Glycosuria (HP:0003076)1.97292197
77Sclerocornea (HP:0000647)1.97072430
78Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92407904
79Pancytopenia (HP:0001876)1.85734955
80Abnormality of glycine metabolism (HP:0010895)1.84480790
81Abnormality of serine family amino acid metabolism (HP:0010894)1.84480790
82Abnormality of the pons (HP:0007361)1.83577481
83Hypomagnesemia (HP:0002917)1.83105679
84Colon cancer (HP:0003003)1.82387827
85Abnormality of vitamin B metabolism (HP:0004340)1.81257326
86Hypoplasia of the uterus (HP:0000013)1.79944009
87Increased muscle lipid content (HP:0009058)1.79632620
88Hyperinsulinemic hypoglycemia (HP:0000825)1.79528744
89Oral leukoplakia (HP:0002745)1.77758064
90Pancreatic islet-cell hyperplasia (HP:0004510)1.77169795
91Abnormality of the vitamin B12 metabolism (HP:0004341)1.76147401
92Hyperglycinuria (HP:0003108)1.76059182
93Ketosis (HP:0001946)1.74751455
94Cystic liver disease (HP:0006706)1.71833122
95Generalized aminoaciduria (HP:0002909)1.71494313
96Type 2 muscle fiber atrophy (HP:0003554)1.70546016
97Hypoplasia of the pons (HP:0012110)1.70178110
98Abnormality of renal resorption (HP:0011038)1.70028081
99Ketoacidosis (HP:0001993)1.69738796
100Large for gestational age (HP:0001520)1.67962753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.20973714
2VRK23.18296944
3TSSK62.99591217
4MST42.88212359
5ZAK2.69726842
6FRK2.59035350
7TXK2.58376058
8EIF2AK32.45450825
9NUAK12.41490531
10BUB12.16050405
11BCKDK2.13739812
12GRK12.09124015
13ADRBK22.01803138
14TLK11.98595499
15TRIM281.91134294
16VRK11.90698872
17STK161.85731609
18SRPK11.79144397
19TAOK31.70778608
20WNK31.64514877
21PLK31.61292860
22EIF2AK11.57194672
23BCR1.48924267
24PINK11.44122791
25WNK41.43115365
26PBK1.38245602
27NME11.35357167
28NEK11.31895073
29BMPR1B1.27931355
30TIE11.26678091
31OXSR11.25670552
32MAP3K121.23867796
33DYRK21.22605420
34CSNK1G31.21680902
35KDR1.18605041
36CSNK1G21.15831866
37CSNK1G11.10985504
38INSRR1.08254754
39STK391.08006820
40PLK21.07095309
41CSNK1A1L1.02751477
42ERBB31.01678240
43MKNK11.01564941
44MKNK20.99900536
45TEC0.99764058
46TESK20.94865329
47PHKG10.94305645
48PHKG20.94305645
49TNIK0.94253937
50MAPK130.90819479
51MAP2K70.85757738
52MAP3K40.84098495
53TAF10.79279944
54PLK40.78842042
55RPS6KA50.78640688
56FLT30.77940853
57DAPK10.76887939
58CDC70.75421454
59MUSK0.72672831
60EIF2AK20.72056653
61PLK10.71355145
62PASK0.71014269
63ITK0.69429899
64IKBKB0.67684332
65PRKCE0.66133868
66ATR0.61809719
67MAPKAPK50.61626741
68KIT0.59060039
69WEE10.59005410
70PRKCQ0.56841540
71PRKCG0.56333798
72DAPK20.51798261
73CSNK2A10.51579909
74CASK0.48560455
75PAK30.47687171
76CSNK1A10.46819297
77MAP2K60.46680444
78PDK20.44796652
79CSNK2A20.43835578
80IKBKE0.42078197
81RPS6KA40.41719390
82MAPKAPK30.41503827
83ADRBK10.41037497
84OBSCN0.39334784
85ATM0.37741866
86LIMK10.36907843
87PRKACA0.36516067
88CAMK2A0.35402607
89AURKB0.34994063
90AURKA0.33859462
91MAP4K10.33550136
92PRKCA0.31680203
93CHEK20.30928076
94CCNB10.30666702
95IGF1R0.30436654
96MYLK0.30405929
97ALK0.30228595
98FES0.29757359
99MINK10.28389829
100GRK70.27421414

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.48151729
2Oxidative phosphorylation_Homo sapiens_hsa001903.64180734
3Protein export_Homo sapiens_hsa030603.28208447
4Parkinsons disease_Homo sapiens_hsa050122.94700621
5RNA polymerase_Homo sapiens_hsa030202.70286136
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44587892
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17675810
8One carbon pool by folate_Homo sapiens_hsa006702.07463332
9Huntingtons disease_Homo sapiens_hsa050162.00809155
10Alzheimers disease_Homo sapiens_hsa050101.87959250
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84269368
12Phototransduction_Homo sapiens_hsa047441.81986638
13RNA degradation_Homo sapiens_hsa030181.79982884
14Ribosome_Homo sapiens_hsa030101.79606350
15Basal transcription factors_Homo sapiens_hsa030221.78413894
16Homologous recombination_Homo sapiens_hsa034401.70108972
17Propanoate metabolism_Homo sapiens_hsa006401.56977442
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54887539
19Asthma_Homo sapiens_hsa053101.52850578
20Sulfur metabolism_Homo sapiens_hsa009201.51187582
21Type I diabetes mellitus_Homo sapiens_hsa049401.49468227
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48581500
23Mismatch repair_Homo sapiens_hsa034301.44000791
24Butanoate metabolism_Homo sapiens_hsa006501.41404718
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.41389378
26Spliceosome_Homo sapiens_hsa030401.38172715
27Allograft rejection_Homo sapiens_hsa053301.35795042
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33692031
29Cardiac muscle contraction_Homo sapiens_hsa042601.32445640
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32257764
31RNA transport_Homo sapiens_hsa030131.32108635
32Primary immunodeficiency_Homo sapiens_hsa053401.31824469
33Autoimmune thyroid disease_Homo sapiens_hsa053201.29524667
34Nitrogen metabolism_Homo sapiens_hsa009101.27611478
35Pyrimidine metabolism_Homo sapiens_hsa002401.26709842
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25147527
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.23496231
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22602582
39Fanconi anemia pathway_Homo sapiens_hsa034601.18681628
40DNA replication_Homo sapiens_hsa030301.15317203
41Purine metabolism_Homo sapiens_hsa002301.12628710
42Tryptophan metabolism_Homo sapiens_hsa003801.09574477
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.09332566
44Non-homologous end-joining_Homo sapiens_hsa034501.08948922
45Collecting duct acid secretion_Homo sapiens_hsa049661.08550428
46Graft-versus-host disease_Homo sapiens_hsa053321.08117246
47Linoleic acid metabolism_Homo sapiens_hsa005911.06037814
48Peroxisome_Homo sapiens_hsa041461.05865261
49Selenocompound metabolism_Homo sapiens_hsa004501.02515680
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02258076
51Nucleotide excision repair_Homo sapiens_hsa034201.01326408
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93865684
53Base excision repair_Homo sapiens_hsa034100.92306920
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88136000
55Fatty acid elongation_Homo sapiens_hsa000620.88026361
56Antigen processing and presentation_Homo sapiens_hsa046120.87191156
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85219579
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81788841
59Rheumatoid arthritis_Homo sapiens_hsa053230.81468540
60Steroid biosynthesis_Homo sapiens_hsa001000.79701437
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79526459
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77505855
63Caffeine metabolism_Homo sapiens_hsa002320.76131940
64Metabolic pathways_Homo sapiens_hsa011000.74706869
65Retinol metabolism_Homo sapiens_hsa008300.72368240
66Glutathione metabolism_Homo sapiens_hsa004800.70097560
67Regulation of autophagy_Homo sapiens_hsa041400.69265633
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69201570
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67242795
70Ether lipid metabolism_Homo sapiens_hsa005650.66684994
71Chemical carcinogenesis_Homo sapiens_hsa052040.65960418
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65070600
73Folate biosynthesis_Homo sapiens_hsa007900.62821340
74beta-Alanine metabolism_Homo sapiens_hsa004100.59966864
75Olfactory transduction_Homo sapiens_hsa047400.59033642
76Pyruvate metabolism_Homo sapiens_hsa006200.57240478
77Nicotine addiction_Homo sapiens_hsa050330.56447547
78Vitamin B6 metabolism_Homo sapiens_hsa007500.56081167
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54797612
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53928669
81Sulfur relay system_Homo sapiens_hsa041220.53023882
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52187495
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.51085066
84Systemic lupus erythematosus_Homo sapiens_hsa053220.50782355
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47794335
86Arachidonic acid metabolism_Homo sapiens_hsa005900.45255518
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43322601
88Hematopoietic cell lineage_Homo sapiens_hsa046400.42933026
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.42718889
90Fatty acid degradation_Homo sapiens_hsa000710.41811196
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37699389
92Fat digestion and absorption_Homo sapiens_hsa049750.37248762
93Taste transduction_Homo sapiens_hsa047420.37204927
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34966679
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31434710
96Fatty acid metabolism_Homo sapiens_hsa012120.31173522
97N-Glycan biosynthesis_Homo sapiens_hsa005100.27937304
98mRNA surveillance pathway_Homo sapiens_hsa030150.27529217
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.26116524
100GABAergic synapse_Homo sapiens_hsa047270.25660895

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