HSP90AB2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)4.48342922
2DNA deamination (GO:0045006)4.37430627
3ribosome assembly (GO:0042255)4.21243818
4cullin deneddylation (GO:0010388)4.10870354
5rRNA modification (GO:0000154)4.10063279
6proteasome assembly (GO:0043248)3.91973130
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.85479285
8nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.83302141
9water-soluble vitamin biosynthetic process (GO:0042364)3.80883216
10protein deneddylation (GO:0000338)3.79142902
11pseudouridine synthesis (GO:0001522)3.77570626
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.77300478
13protein neddylation (GO:0045116)3.77286044
14rRNA methylation (GO:0031167)3.71337875
15DNA double-strand break processing (GO:0000729)3.68842197
16somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.60808625
17isotype switching (GO:0045190)3.60808625
18somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.60808625
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.56383457
20termination of RNA polymerase III transcription (GO:0006386)3.56383457
21ATP synthesis coupled proton transport (GO:0015986)3.55643689
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55643689
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46629202
24regulation of mitotic spindle checkpoint (GO:1903504)3.46629202
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.46264386
26chromatin remodeling at centromere (GO:0031055)3.42565953
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.39626648
28NADH dehydrogenase complex assembly (GO:0010257)3.39626648
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39626648
30spliceosomal snRNP assembly (GO:0000387)3.35211571
31protein complex biogenesis (GO:0070271)3.32863262
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32361467
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29971809
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29971809
35mitochondrial respiratory chain complex assembly (GO:0033108)3.29961145
36DNA damage response, detection of DNA damage (GO:0042769)3.29374007
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.26734218
38establishment of integrated proviral latency (GO:0075713)3.24769345
39DNA replication-dependent nucleosome organization (GO:0034723)3.24597160
40DNA replication-dependent nucleosome assembly (GO:0006335)3.24597160
41CENP-A containing nucleosome assembly (GO:0034080)3.23393250
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17244249
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14485048
44DNA catabolic process, exonucleolytic (GO:0000738)3.13941072
45negative regulation of telomere maintenance (GO:0032205)3.13716758
46DNA replication checkpoint (GO:0000076)3.13301151
47histone mRNA metabolic process (GO:0008334)3.12185145
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.10726194
49chaperone-mediated protein transport (GO:0072321)3.10479763
50tRNA processing (GO:0008033)3.08961300
51mitochondrial RNA metabolic process (GO:0000959)3.08817529
527-methylguanosine mRNA capping (GO:0006370)3.08214050
53respiratory chain complex IV assembly (GO:0008535)3.07660188
54histone exchange (GO:0043486)3.05224285
55tRNA metabolic process (GO:0006399)3.03908555
56replication fork processing (GO:0031297)3.02957142
577-methylguanosine RNA capping (GO:0009452)3.00685223
58RNA capping (GO:0036260)3.00685223
59regulation of centriole replication (GO:0046599)3.00583034
60regulation of cellular amino acid metabolic process (GO:0006521)3.00469518
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99491788
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94935949
63rRNA processing (GO:0006364)2.94787987
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93985777
65somatic hypermutation of immunoglobulin genes (GO:0016446)2.93985777
66termination of RNA polymerase I transcription (GO:0006363)2.93792340
67IMP biosynthetic process (GO:0006188)2.93410753
68negative regulation of ligase activity (GO:0051352)2.91227543
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91227543
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90326799
71rRNA metabolic process (GO:0016072)2.90102265
72amino acid activation (GO:0043038)2.89789276
73tRNA aminoacylation (GO:0043039)2.89789276
74transcription elongation from RNA polymerase I promoter (GO:0006362)2.89417128
75tRNA modification (GO:0006400)2.86336765
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86242650
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86242650
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86242650
79peptidyl-histidine modification (GO:0018202)2.85058833
80tRNA aminoacylation for protein translation (GO:0006418)2.85047177
81somatic recombination of immunoglobulin gene segments (GO:0016447)2.85012243
82L-fucose metabolic process (GO:0042354)2.84934656
83L-fucose catabolic process (GO:0042355)2.84934656
84fucose catabolic process (GO:0019317)2.84934656
85ncRNA metabolic process (GO:0034660)2.83697959
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83193391
87ribosome biogenesis (GO:0042254)2.82904724
88protein-cofactor linkage (GO:0018065)2.82618317
89ncRNA catabolic process (GO:0034661)2.82609469
90folic acid-containing compound biosynthetic process (GO:0009396)2.82365981
91rRNA catabolic process (GO:0016075)2.79443243
92somatic diversification of immunoglobulins (GO:0016445)2.79332308
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77390384
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77390384
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.75187570
96preassembly of GPI anchor in ER membrane (GO:0016254)2.74179896
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73292239
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.73292239
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72206965
100DNA-templated transcription, termination (GO:0006353)2.71969650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.03729270
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.33282453
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.84526082
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18693606
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12411262
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91424571
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.88178387
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83993318
9E2F7_22180533_ChIP-Seq_HELA_Human2.81640894
10ELK1_19687146_ChIP-ChIP_HELA_Human2.79599239
11VDR_23849224_ChIP-Seq_CD4+_Human2.78945520
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.77533369
13ZNF274_21170338_ChIP-Seq_K562_Hela2.66210314
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64172555
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59666961
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56502127
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50403566
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45339809
19FOXP3_21729870_ChIP-Seq_TREG_Human2.32517902
20VDR_22108803_ChIP-Seq_LS180_Human2.27114114
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.24486165
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10711931
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05790095
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03745491
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.00563117
26MYC_18940864_ChIP-ChIP_HL60_Human2.00295707
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96952640
28* EWS_26573619_Chip-Seq_HEK293_Human1.96453032
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90967665
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.86172357
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84065275
32DCP1A_22483619_ChIP-Seq_HELA_Human1.82817304
33FUS_26573619_Chip-Seq_HEK293_Human1.78736323
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78189426
35GABP_19822575_ChIP-Seq_HepG2_Human1.77431933
36TTF2_22483619_ChIP-Seq_HELA_Human1.74370916
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70684716
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67881581
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66673757
40IGF1R_20145208_ChIP-Seq_DFB_Human1.65351530
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64435905
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62656312
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61366683
44TAF15_26573619_Chip-Seq_HEK293_Human1.57840761
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49591416
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48244405
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48050304
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43036466
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42519199
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.41643903
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36097749
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34552575
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33342371
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33063745
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31802322
56XRN2_22483619_ChIP-Seq_HELA_Human1.31333857
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30243974
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29703233
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28765560
60TP53_22573176_ChIP-Seq_HFKS_Human1.27945229
61IRF1_19129219_ChIP-ChIP_H3396_Human1.25316057
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.24659653
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24192576
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23683668
65P300_19829295_ChIP-Seq_ESCs_Human1.22225842
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19563245
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19558337
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19316558
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15952434
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.11864229
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10543811
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10471042
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.08437685
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08011046
75* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06853622
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06250741
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05351392
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.00215930
79KDM5A_27292631_Chip-Seq_BREAST_Human0.99628915
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97770652
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.97770652
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96473351
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.96104922
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95937226
85CBP_20019798_ChIP-Seq_JUKART_Human0.95937226
86* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95758361
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95189511
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93881108
89NANOG_19829295_ChIP-Seq_ESCs_Human0.91600555
90SOX2_19829295_ChIP-Seq_ESCs_Human0.91600555
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90526073
92CIITA_25753668_ChIP-Seq_RAJI_Human0.90390034
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.89741713
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89105773
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89053931
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86569354
97ER_23166858_ChIP-Seq_MCF-7_Human0.82982905
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82200866
99HOXB7_26014856_ChIP-Seq_BT474_Human0.81570949
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.80971802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.08257149
2MP0008058_abnormal_DNA_repair3.80896242
3MP0003693_abnormal_embryo_hatching3.10299844
4MP0010094_abnormal_chromosome_stability3.03633907
5MP0002102_abnormal_ear_morphology2.82584392
6MP0003787_abnormal_imprinting2.77133691
7MP0004957_abnormal_blastocyst_morpholog2.59261253
8MP0006072_abnormal_retinal_apoptosis2.46404090
9MP0003786_premature_aging2.29809788
10MP0003111_abnormal_nucleus_morphology2.21006206
11MP0003121_genomic_imprinting2.06226396
12MP0006292_abnormal_olfactory_placode2.05255643
13MP0003718_maternal_effect2.04332155
14MP0006035_abnormal_mitochondrial_morpho2.04067087
15MP0005084_abnormal_gallbladder_morpholo2.02527907
16MP0001529_abnormal_vocalization2.01901514
17MP0003122_maternal_imprinting1.90371547
18MP0005645_abnormal_hypothalamus_physiol1.86569757
19MP0009697_abnormal_copulation1.84783583
20MP0008007_abnormal_cellular_replicative1.77214617
21MP0006036_abnormal_mitochondrial_physio1.74903868
22MP0003077_abnormal_cell_cycle1.71029627
23MP0004147_increased_porphyrin_level1.65959747
24MP0002837_dystrophic_cardiac_calcinosis1.58070321
25MP0000372_irregular_coat_pigmentation1.55817315
26MP0008872_abnormal_physiological_respon1.55589081
27MP0003195_calcinosis1.54421007
28MP0001293_anophthalmia1.53898681
29MP0001984_abnormal_olfaction1.53055018
30MP0002736_abnormal_nociception_after1.50832650
31MP0001968_abnormal_touch/_nociception1.50671619
32MP0001188_hyperpigmentation1.49047378
33MP0009046_muscle_twitch1.46771438
34MP0005253_abnormal_eye_physiology1.41263701
35MP0002938_white_spotting1.40876350
36MP0003011_delayed_dark_adaptation1.40723864
37MP0005551_abnormal_eye_electrophysiolog1.39917077
38MP0003567_abnormal_fetal_cardiomyocyte1.39692876
39MP0008932_abnormal_embryonic_tissue1.39621474
40MP0008875_abnormal_xenobiotic_pharmacok1.33690044
41MP0000569_abnormal_digit_pigmentation1.30520043
42MP0006276_abnormal_autonomic_nervous1.26325038
43MP0003186_abnormal_redox_activity1.25143353
44MP0008789_abnormal_olfactory_epithelium1.20048346
45MP0002751_abnormal_autonomic_nervous1.18228257
46MP0000631_abnormal_neuroendocrine_gland1.17764801
47MP0003806_abnormal_nucleotide_metabolis1.14720200
48MP0008057_abnormal_DNA_replication1.11527765
49MP0004145_abnormal_muscle_electrophysio1.10012202
50MP0005646_abnormal_pituitary_gland1.08930482
51MP0008995_early_reproductive_senescence1.08453356
52MP0001929_abnormal_gametogenesis1.07359387
53MP0002163_abnormal_gland_morphology1.06071307
54MP0003890_abnormal_embryonic-extraembry1.04523919
55MP0002138_abnormal_hepatobiliary_system1.04479906
56MP0002272_abnormal_nervous_system1.03312921
57MP0002210_abnormal_sex_determination1.02867440
58MP0004142_abnormal_muscle_tone0.99717780
59MP0005075_abnormal_melanosome_morpholog0.98411980
60MP0002234_abnormal_pharynx_morphology0.98158111
61MP0009745_abnormal_behavioral_response0.96720328
62MP0003119_abnormal_digestive_system0.93232306
63MP0005410_abnormal_fertilization0.93109882
64MP0001905_abnormal_dopamine_level0.92338286
65MP0003937_abnormal_limbs/digits/tail_de0.91711729
66MP0003880_abnormal_central_pattern0.91666394
67MP0002160_abnormal_reproductive_system0.90923716
68MP0001919_abnormal_reproductive_system0.90438468
69MP0005499_abnormal_olfactory_system0.89914188
70MP0005394_taste/olfaction_phenotype0.89914188
71MP0005389_reproductive_system_phenotype0.86964389
72MP0005671_abnormal_response_to0.85793061
73MP0004133_heterotaxia0.85557278
74MP0005379_endocrine/exocrine_gland_phen0.85479541
75MP0001986_abnormal_taste_sensitivity0.85313005
76MP0000427_abnormal_hair_cycle0.85112386
77MP0000358_abnormal_cell_content/0.84153542
78MP0004885_abnormal_endolymph0.84014915
79MP0002735_abnormal_chemical_nociception0.83488892
80MP0000653_abnormal_sex_gland0.81943787
81MP0001145_abnormal_male_reproductive0.81302787
82MP0002638_abnormal_pupillary_reflex0.81138867
83MP0001730_embryonic_growth_arrest0.80807880
84MP0000647_abnormal_sebaceous_gland0.80140025
85MP0005332_abnormal_amino_acid0.77189413
86MP0003698_abnormal_male_reproductive0.77101843
87MP0004215_abnormal_myocardial_fiber0.76503339
88MP0004043_abnormal_pH_regulation0.75299300
89MP0002084_abnormal_developmental_patter0.73082763
90MP0001873_stomach_inflammation0.72890691
91MP0002090_abnormal_vision0.71520855
92MP0001286_abnormal_eye_development0.71493351
93MP0002254_reproductive_system_inflammat0.71410356
94MP0001486_abnormal_startle_reflex0.70306638
95MP0002733_abnormal_thermal_nociception0.69946828
96MP0001485_abnormal_pinna_reflex0.69801465
97MP0001697_abnormal_embryo_size0.69743044
98MP0008775_abnormal_heart_ventricle0.68897994
99MP0002184_abnormal_innervation0.67907646
100MP0004742_abnormal_vestibular_system0.65682363

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.01111798
2Acute encephalopathy (HP:0006846)3.67574008
3Abnormal mitochondria in muscle tissue (HP:0008316)3.46599370
4Abnormality of the labia minora (HP:0012880)3.44034838
5Increased CSF lactate (HP:0002490)3.39694922
6Mitochondrial inheritance (HP:0001427)3.38576705
7Progressive macrocephaly (HP:0004481)3.32515966
8Increased hepatocellular lipid droplets (HP:0006565)3.28248066
9Methylmalonic acidemia (HP:0002912)3.15143621
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10397069
11Lipid accumulation in hepatocytes (HP:0006561)3.06456738
12Pancreatic cysts (HP:0001737)3.04303797
13Progressive inability to walk (HP:0002505)2.97254694
14Increased serum lactate (HP:0002151)2.92403212
15Hepatocellular necrosis (HP:0001404)2.82244103
16Abnormality of midbrain morphology (HP:0002418)2.81851081
17Molar tooth sign on MRI (HP:0002419)2.81851081
18Colon cancer (HP:0003003)2.78961153
19Pancreatic fibrosis (HP:0100732)2.75961259
20Nephronophthisis (HP:0000090)2.73580004
21Cerebral edema (HP:0002181)2.70052352
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68974515
23Hepatic necrosis (HP:0002605)2.61435409
243-Methylglutaconic aciduria (HP:0003535)2.54314350
25True hermaphroditism (HP:0010459)2.53437518
26Methylmalonic aciduria (HP:0012120)2.47909239
27Pendular nystagmus (HP:0012043)2.38452837
28Abnormality of the ileum (HP:0001549)2.33033997
29Meckel diverticulum (HP:0002245)2.31815041
30Lactic acidosis (HP:0003128)2.31708334
31Abnormality of alanine metabolism (HP:0010916)2.30331789
32Hyperalaninemia (HP:0003348)2.30331789
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30331789
34Renal Fanconi syndrome (HP:0001994)2.29320036
35Medial flaring of the eyebrow (HP:0010747)2.28062907
36Inability to walk (HP:0002540)2.27240504
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.24257567
38Congenital stationary night blindness (HP:0007642)2.22471599
39Abolished electroretinogram (ERG) (HP:0000550)2.21516209
40Abnormality of the renal medulla (HP:0100957)2.21321241
41Volvulus (HP:0002580)2.21306306
42Hyperglycinemia (HP:0002154)2.19645223
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16937338
44Abnormality of serum amino acid levels (HP:0003112)2.16682109
45Optic disc pallor (HP:0000543)2.16024448
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14990506
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14990506
48Aplasia/hypoplasia of the uterus (HP:0008684)2.14679091
49Abnormality of the pons (HP:0007361)2.13190255
50Abnormal biliary tract physiology (HP:0012439)2.12501881
51Bile duct proliferation (HP:0001408)2.12501881
52Abnormality of the renal cortex (HP:0011035)2.11702745
53Sensory axonal neuropathy (HP:0003390)2.08665060
54Exercise intolerance (HP:0003546)2.08280522
55Abnormality of the preputium (HP:0100587)2.08274911
56Leukodystrophy (HP:0002415)2.06959584
57Hyperglycinuria (HP:0003108)2.06369690
58Degeneration of anterior horn cells (HP:0002398)2.02464971
59Abnormality of the anterior horn cell (HP:0006802)2.02464971
60Sclerocornea (HP:0000647)2.00937515
61Abnormality of glycine metabolism (HP:0010895)2.00697274
62Abnormality of serine family amino acid metabolism (HP:0010894)2.00697274
63Lethargy (HP:0001254)1.99914269
64Increased serum pyruvate (HP:0003542)1.98250866
65Exertional dyspnea (HP:0002875)1.97200431
66Prominent metopic ridge (HP:0005487)1.96725895
67Increased intramyocellular lipid droplets (HP:0012240)1.96421057
68Abnormality of methionine metabolism (HP:0010901)1.94557666
69Type I transferrin isoform profile (HP:0003642)1.94044378
70Abnormal protein glycosylation (HP:0012346)1.92769528
71Abnormal glycosylation (HP:0012345)1.92769528
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92769528
73Abnormal protein N-linked glycosylation (HP:0012347)1.92769528
74Abnormality of chromosome stability (HP:0003220)1.90204220
75Hypoplasia of the pons (HP:0012110)1.87873037
76Abnormality of vitamin B metabolism (HP:0004340)1.87749739
77Abnormality of the vitamin B12 metabolism (HP:0004341)1.86220476
78Renal cortical cysts (HP:0000803)1.85979468
79Absent thumb (HP:0009777)1.85272862
80Respiratory failure (HP:0002878)1.83877997
81Hypothermia (HP:0002045)1.81876493
82Abnormality of the metopic suture (HP:0005556)1.80272403
83Ependymoma (HP:0002888)1.80111303
84IgG deficiency (HP:0004315)1.79772521
85Type II lissencephaly (HP:0007260)1.79648709
86Congenital primary aphakia (HP:0007707)1.78061573
87Cerebral hypomyelination (HP:0006808)1.77625171
88Abnormality of glycolysis (HP:0004366)1.76965189
89Multiple enchondromatosis (HP:0005701)1.74509226
90Gait imbalance (HP:0002141)1.74260552
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74255714
92Tubular atrophy (HP:0000092)1.73702784
93Congenital, generalized hypertrichosis (HP:0004540)1.73162776
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72129451
95Nephrogenic diabetes insipidus (HP:0009806)1.71668902
96Chromsome breakage (HP:0040012)1.70027844
97Horseshoe kidney (HP:0000085)1.68439296
98Lissencephaly (HP:0001339)1.66803412
99Hypoplasia of the uterus (HP:0000013)1.66427738
100Small intestinal stenosis (HP:0012848)1.61585960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.42087055
2MST43.56613025
3ZAK3.32201166
4EIF2AK32.78686627
5SRPK12.77316450
6TRIM282.59358765
7MKNK22.55828857
8MAP4K22.42172632
9BUB12.39047884
10MKNK12.22673537
11NUAK12.19705715
12NEK12.18417962
13VRK22.17630641
14TNIK2.08808132
15CDC72.07910794
16PLK32.03655634
17DYRK31.95639806
18EIF2AK11.88841337
19WNK31.81628023
20VRK11.80956016
21TLK11.72199658
22PLK41.71866001
23STK161.70915017
24BMPR1B1.65799294
25BCR1.56798265
26WNK41.47723992
27FRK1.46008374
28TTK1.41758302
29GRK11.37567306
30MAP3K41.33008552
31NME11.30925540
32BCKDK1.29152742
33ADRBK21.28396017
34OXSR11.27268145
35PLK11.24564997
36TAF11.24407702
37RPS6KA41.17925403
38PINK11.17602627
39TIE11.16398323
40CSNK1G31.15433745
41CSNK1G11.12921265
42STK391.06397632
43CSNK1G21.04910066
44CSNK1A1L1.02435733
45ATR1.02134143
46ALK1.01104340
47MAP2K70.96774156
48ERBB30.93447949
49DYRK20.91408807
50PBK0.91279103
51PLK20.89031553
52EIF2AK20.86192123
53TXK0.85493519
54MAPKAPK30.83689498
55AURKB0.80910891
56PNCK0.80864168
57PASK0.78131551
58RPS6KA50.77607717
59MAPKAPK50.71936465
60CHEK20.71843178
61WEE10.71514553
62CDK190.64542876
63ATM0.64259824
64STK38L0.63990747
65CHEK10.63595473
66INSRR0.63203152
67MAPK130.63115678
68CSNK2A20.62330327
69CSNK1E0.61980561
70TAOK30.60779011
71CSNK2A10.55690322
72ACVR1B0.55451793
73CASK0.55006412
74PHKG20.52635757
75PHKG10.52635757
76PAK30.49494622
77TEC0.48637438
78DAPK10.47643474
79PRKCE0.46367944
80PRKCG0.46111519
81BRSK20.45226244
82CSNK1A10.41045628
83RPS6KB20.40771141
84MINK10.39742614
85MAP3K120.38345274
86BRD40.37730424
87AURKA0.36599504
88PRKDC0.34730858
89NEK20.29066804
90TGFBR10.28781976
91PRKCI0.28222887
92CDK10.28131598
93STK100.26878581
94SIK30.26742358
95PRKACB0.26288836
96LIMK10.26260461
97CSNK1D0.26240735
98CDK20.25729087
99IKBKB0.24005578
100MAP2K60.23048089

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.96949532
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46232960
3Protein export_Homo sapiens_hsa030603.37195899
4RNA polymerase_Homo sapiens_hsa030202.89999141
5Basal transcription factors_Homo sapiens_hsa030222.55375596
6Oxidative phosphorylation_Homo sapiens_hsa001902.55003912
7One carbon pool by folate_Homo sapiens_hsa006702.54643015
8RNA degradation_Homo sapiens_hsa030182.31301945
9Mismatch repair_Homo sapiens_hsa034302.27177177
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23655298
11Spliceosome_Homo sapiens_hsa030402.22718672
12Non-homologous end-joining_Homo sapiens_hsa034502.22419901
13Parkinsons disease_Homo sapiens_hsa050122.20998355
14RNA transport_Homo sapiens_hsa030132.19261407
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07628329
16Homologous recombination_Homo sapiens_hsa034402.06105475
17DNA replication_Homo sapiens_hsa030301.98582145
18Propanoate metabolism_Homo sapiens_hsa006401.89091703
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84168895
20Fanconi anemia pathway_Homo sapiens_hsa034601.72224783
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70967826
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57371989
23Selenocompound metabolism_Homo sapiens_hsa004501.56556358
24Ribosome_Homo sapiens_hsa030101.56113383
25Base excision repair_Homo sapiens_hsa034101.55814284
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55045464
27Nucleotide excision repair_Homo sapiens_hsa034201.53050438
28Huntingtons disease_Homo sapiens_hsa050161.50523983
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.48294328
30Pyrimidine metabolism_Homo sapiens_hsa002401.46952060
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34940199
32Phototransduction_Homo sapiens_hsa047441.33389475
33Asthma_Homo sapiens_hsa053101.31995221
34Purine metabolism_Homo sapiens_hsa002301.27100909
35Steroid biosynthesis_Homo sapiens_hsa001001.25264459
36Alzheimers disease_Homo sapiens_hsa050101.22576393
37Butanoate metabolism_Homo sapiens_hsa006501.22295083
38Sulfur metabolism_Homo sapiens_hsa009201.21841364
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07775652
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06362928
41mRNA surveillance pathway_Homo sapiens_hsa030151.03044528
42Type I diabetes mellitus_Homo sapiens_hsa049401.02763570
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.02443668
44Vitamin B6 metabolism_Homo sapiens_hsa007500.97626365
45Pyruvate metabolism_Homo sapiens_hsa006200.95133599
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90901195
47Allograft rejection_Homo sapiens_hsa053300.90353416
48Linoleic acid metabolism_Homo sapiens_hsa005910.85738331
49Fatty acid elongation_Homo sapiens_hsa000620.80606240
50Autoimmune thyroid disease_Homo sapiens_hsa053200.79138281
51Systemic lupus erythematosus_Homo sapiens_hsa053220.75462633
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75223315
53Olfactory transduction_Homo sapiens_hsa047400.74902822
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74603609
55Peroxisome_Homo sapiens_hsa041460.73416331
56Nitrogen metabolism_Homo sapiens_hsa009100.71854385
57Tryptophan metabolism_Homo sapiens_hsa003800.71675155
58Regulation of autophagy_Homo sapiens_hsa041400.71559882
59Metabolic pathways_Homo sapiens_hsa011000.67965137
60Cardiac muscle contraction_Homo sapiens_hsa042600.67584636
61Ether lipid metabolism_Homo sapiens_hsa005650.65860289
62Cell cycle_Homo sapiens_hsa041100.64989773
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64586482
64beta-Alanine metabolism_Homo sapiens_hsa004100.63016373
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58872185
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57702183
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.57684610
68Nicotine addiction_Homo sapiens_hsa050330.56860233
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54980657
70Glutathione metabolism_Homo sapiens_hsa004800.54191188
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51876280
72Collecting duct acid secretion_Homo sapiens_hsa049660.51388694
73Epstein-Barr virus infection_Homo sapiens_hsa051690.50957578
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50440942
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50046765
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49122333
77Antigen processing and presentation_Homo sapiens_hsa046120.47001912
78Primary immunodeficiency_Homo sapiens_hsa053400.45789828
79Folate biosynthesis_Homo sapiens_hsa007900.45588348
80Graft-versus-host disease_Homo sapiens_hsa053320.45231973
81Carbon metabolism_Homo sapiens_hsa012000.42799902
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42544171
83p53 signaling pathway_Homo sapiens_hsa041150.40976228
84Caffeine metabolism_Homo sapiens_hsa002320.40651850
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39122133
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38852323
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37681475
88Biosynthesis of amino acids_Homo sapiens_hsa012300.36986089
89Arginine and proline metabolism_Homo sapiens_hsa003300.35963024
90Oocyte meiosis_Homo sapiens_hsa041140.35471523
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35208358
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32432295
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32256820
94Sulfur relay system_Homo sapiens_hsa041220.30876078
95Rheumatoid arthritis_Homo sapiens_hsa053230.29385687
96Taste transduction_Homo sapiens_hsa047420.28497412
97Herpes simplex infection_Homo sapiens_hsa051680.28213961
98Fatty acid metabolism_Homo sapiens_hsa012120.27204162
99Alcoholism_Homo sapiens_hsa050340.25610570
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25600681

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