HSP90AA2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.79325068
2DNA deamination (GO:0045006)5.07318203
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.06046860
4behavioral response to nicotine (GO:0035095)4.99394022
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85560970
6ATP synthesis coupled proton transport (GO:0015986)4.85560970
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57406847
8protein neddylation (GO:0045116)4.22526305
9respiratory electron transport chain (GO:0022904)4.12228125
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.11171686
11electron transport chain (GO:0022900)4.10808436
12protein complex biogenesis (GO:0070271)3.98494388
13cytidine deamination (GO:0009972)3.84234437
14cytidine metabolic process (GO:0046087)3.84234437
15cytidine catabolic process (GO:0006216)3.84234437
16chaperone-mediated protein transport (GO:0072321)3.79342418
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70129697
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.70129697
19NADH dehydrogenase complex assembly (GO:0010257)3.70129697
20mitochondrial respiratory chain complex assembly (GO:0033108)3.66639261
21water-soluble vitamin biosynthetic process (GO:0042364)3.54590314
22somite development (GO:0061053)3.46099783
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32983796
24response to pheromone (GO:0019236)3.28801704
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20366129
26proteasome assembly (GO:0043248)3.20316316
27nonmotile primary cilium assembly (GO:0035058)3.18506333
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.12569573
29hydrogen ion transmembrane transport (GO:1902600)3.11532526
30protein-cofactor linkage (GO:0018065)3.09674165
31indolalkylamine metabolic process (GO:0006586)3.05932547
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05868269
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04240252
34proton transport (GO:0015992)3.03847860
35respiratory chain complex IV assembly (GO:0008535)2.97031461
36hydrogen transport (GO:0006818)2.95895541
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88185469
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88185469
39intracellular protein transmembrane import (GO:0044743)2.86486718
40kynurenine metabolic process (GO:0070189)2.82401849
41sequestering of actin monomers (GO:0042989)2.82224722
42neuron fate determination (GO:0048664)2.81938508
43ATP biosynthetic process (GO:0006754)2.79835557
44regulation of hexokinase activity (GO:1903299)2.79236615
45regulation of glucokinase activity (GO:0033131)2.79236615
46indole-containing compound catabolic process (GO:0042436)2.79226070
47indolalkylamine catabolic process (GO:0046218)2.79226070
48tryptophan catabolic process (GO:0006569)2.79226070
49regulation of action potential (GO:0098900)2.77845904
50DNA damage response, detection of DNA damage (GO:0042769)2.75616296
51negative regulation of telomere maintenance (GO:0032205)2.75365416
52cytochrome complex assembly (GO:0017004)2.74458007
53purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70816689
54platelet dense granule organization (GO:0060155)2.70694331
55epithelial cilium movement (GO:0003351)2.69663500
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69106881
57ribosomal small subunit assembly (GO:0000028)2.64035053
58preassembly of GPI anchor in ER membrane (GO:0016254)2.62545275
59protein polyglutamylation (GO:0018095)2.61761240
60L-fucose catabolic process (GO:0042355)2.61464182
61fucose catabolic process (GO:0019317)2.61464182
62L-fucose metabolic process (GO:0042354)2.61464182
63piRNA metabolic process (GO:0034587)2.57455180
64regulation of cilium movement (GO:0003352)2.54739759
65inner mitochondrial membrane organization (GO:0007007)2.52897662
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.52488882
67termination of RNA polymerase III transcription (GO:0006386)2.52488882
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52055758
69cotranslational protein targeting to membrane (GO:0006613)2.48411786
70neuronal action potential (GO:0019228)2.46781123
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45418467
72substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.44699102
73substrate-independent telencephalic tangential migration (GO:0021826)2.44699102
74pyrimidine nucleobase catabolic process (GO:0006208)2.44454268
75translational termination (GO:0006415)2.43675019
76protein targeting to ER (GO:0045047)2.43085486
77organelle disassembly (GO:1903008)2.42565811
78indole-containing compound metabolic process (GO:0042430)2.40252616
79chromatin remodeling at centromere (GO:0031055)2.40242378
80protein K6-linked ubiquitination (GO:0085020)2.40220526
81viral transcription (GO:0019083)2.39783612
82synaptic transmission, cholinergic (GO:0007271)2.39746883
83negative regulation by host of viral transcription (GO:0043922)2.38298804
84cell proliferation in forebrain (GO:0021846)2.37203445
85negative regulation of T cell differentiation in thymus (GO:0033085)2.37035932
86mannosylation (GO:0097502)2.36885385
87negative regulation of heart rate (GO:0010459)2.36289767
88tryptophan metabolic process (GO:0006568)2.35178417
89GTP biosynthetic process (GO:0006183)2.35132738
90GPI anchor metabolic process (GO:0006505)2.34201100
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.32332441
92axoneme assembly (GO:0035082)2.31099083
93tRNA processing (GO:0008033)2.30912175
94ubiquinone metabolic process (GO:0006743)2.30534126
95transmission of nerve impulse (GO:0019226)2.30299421
96protein localization to endoplasmic reticulum (GO:0070972)2.29653442
97regulation of cellular amino acid metabolic process (GO:0006521)2.29618633
98ribosomal large subunit biogenesis (GO:0042273)2.28847223
99cilium movement (GO:0003341)2.28383983
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.27401350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.95673562
2ZNF274_21170338_ChIP-Seq_K562_Hela3.16484941
3VDR_22108803_ChIP-Seq_LS180_Human3.01559967
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.90449745
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85953528
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71162820
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68082971
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63738160
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.58710632
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57774226
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25807688
12GBX2_23144817_ChIP-Seq_PC3_Human2.15022729
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12715417
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11458871
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08906122
16EWS_26573619_Chip-Seq_HEK293_Human2.05994762
17IGF1R_20145208_ChIP-Seq_DFB_Human2.04783757
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01194434
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99326118
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.94455810
21FUS_26573619_Chip-Seq_HEK293_Human1.94115139
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88558742
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.88424628
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87430110
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84999409
26P300_19829295_ChIP-Seq_ESCs_Human1.78230143
27ELK1_19687146_ChIP-ChIP_HELA_Human1.76309512
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71267344
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66029774
30VDR_23849224_ChIP-Seq_CD4+_Human1.65669726
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.65204032
32TAF15_26573619_Chip-Seq_HEK293_Human1.65102349
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60874852
34MYC_18940864_ChIP-ChIP_HL60_Human1.57728854
35ER_23166858_ChIP-Seq_MCF-7_Human1.57185533
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55649606
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.52100661
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.51450517
39TP53_22573176_ChIP-Seq_HFKS_Human1.50925706
40RNF2_27304074_Chip-Seq_NSC_Mouse1.48578259
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44859251
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42176123
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42084667
44CBP_20019798_ChIP-Seq_JUKART_Human1.35608189
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35608189
46BCAT_22108803_ChIP-Seq_LS180_Human1.34884584
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34726689
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.33868976
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32602729
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31030659
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31030659
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30944270
53REST_21632747_ChIP-Seq_MESCs_Mouse1.29129033
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28605816
55NANOG_19829295_ChIP-Seq_ESCs_Human1.28286426
56SOX2_19829295_ChIP-Seq_ESCs_Human1.28286426
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27991650
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26800725
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23140847
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.21715606
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21715606
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18170396
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17238241
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17040526
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.16557588
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.15322276
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13644274
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13531581
69HTT_18923047_ChIP-ChIP_STHdh_Human1.12963453
70TCF4_22108803_ChIP-Seq_LS180_Human1.11561909
71SMAD4_21799915_ChIP-Seq_A2780_Human1.09193908
72FOXP3_21729870_ChIP-Seq_TREG_Human1.07839225
73AR_25329375_ChIP-Seq_VCAP_Human1.07598821
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06565898
75AR_20517297_ChIP-Seq_VCAP_Human1.06310627
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.05786804
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05520045
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05130221
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04770669
80NCOR_22424771_ChIP-Seq_293T_Human1.04131507
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04006019
82IRF1_19129219_ChIP-ChIP_H3396_Human1.03542376
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03002896
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02775198
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02630852
86P53_22387025_ChIP-Seq_ESCs_Mouse1.02258568
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00867077
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.00121785
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.98662016
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98402229
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96650537
92RUNX2_22187159_ChIP-Seq_PCA_Human0.96122510
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96011642
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95748881
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95580036
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.95398656
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95257791
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.95137022
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94946610
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.93476836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.03352616
2MP0009379_abnormal_foot_pigmentation2.99531480
3MP0000569_abnormal_digit_pigmentation2.69425086
4MP0008877_abnormal_DNA_methylation2.47679809
5MP0002102_abnormal_ear_morphology2.45493912
6MP0006072_abnormal_retinal_apoptosis2.39649386
7MP0003880_abnormal_central_pattern2.33067146
8MP0003787_abnormal_imprinting2.02502261
9MP0002837_dystrophic_cardiac_calcinosis2.00616668
10MP0004142_abnormal_muscle_tone1.98313811
11MP0005551_abnormal_eye_electrophysiolog1.95284163
12MP0002277_abnormal_respiratory_mucosa1.93777970
13MP0004885_abnormal_endolymph1.92789461
14MP0001529_abnormal_vocalization1.91946713
15MP0005084_abnormal_gallbladder_morpholo1.90573957
16MP0005645_abnormal_hypothalamus_physiol1.90019663
17MP0001968_abnormal_touch/_nociception1.88691441
18MP0005646_abnormal_pituitary_gland1.84795621
19MP0001905_abnormal_dopamine_level1.81664849
20MP0006276_abnormal_autonomic_nervous1.80655784
21MP0005423_abnormal_somatic_nervous1.78351581
22MP0004742_abnormal_vestibular_system1.74080429
23MP0002272_abnormal_nervous_system1.73882710
24MP0002736_abnormal_nociception_after1.72772927
25MP0003011_delayed_dark_adaptation1.71942806
26MP0009745_abnormal_behavioral_response1.70730712
27MP0002163_abnormal_gland_morphology1.69154900
28MP0003195_calcinosis1.68664379
29MP0001485_abnormal_pinna_reflex1.66766912
30MP0002938_white_spotting1.63375649
31MP0001188_hyperpigmentation1.61454931
32MP0003136_yellow_coat_color1.60266898
33MP0000631_abnormal_neuroendocrine_gland1.58318765
34MP0004147_increased_porphyrin_level1.55643325
35MP0004133_heterotaxia1.54003309
36MP0003283_abnormal_digestive_organ1.52551904
37MP0008875_abnormal_xenobiotic_pharmacok1.44331284
38MP0005253_abnormal_eye_physiology1.43893578
39MP0000372_irregular_coat_pigmentation1.43306176
40MP0002876_abnormal_thyroid_physiology1.43185275
41MP0003122_maternal_imprinting1.42295700
42MP0008872_abnormal_physiological_respon1.41330431
43MP0005671_abnormal_response_to1.40759734
44MP0000778_abnormal_nervous_system1.38529793
45MP0003121_genomic_imprinting1.37111326
46MP0001486_abnormal_startle_reflex1.36926185
47MP0002638_abnormal_pupillary_reflex1.36741747
48MP0009046_muscle_twitch1.28648062
49MP0002572_abnormal_emotion/affect_behav1.28203654
50MP0005379_endocrine/exocrine_gland_phen1.22745966
51MP0004145_abnormal_muscle_electrophysio1.22430905
52MP0001986_abnormal_taste_sensitivity1.18670245
53MP0002095_abnormal_skin_pigmentation1.17604841
54MP0003646_muscle_fatigue1.17135537
55MP0002064_seizures1.17131441
56MP0001970_abnormal_pain_threshold1.16367049
57MP0001984_abnormal_olfaction1.16015580
58MP0002557_abnormal_social/conspecific_i1.15774842
59MP0008789_abnormal_olfactory_epithelium1.14795204
60MP0002067_abnormal_sensory_capabilities1.13321432
61MP0005389_reproductive_system_phenotype1.12976206
62MP0003878_abnormal_ear_physiology1.12099979
63MP0005377_hearing/vestibular/ear_phenot1.12099979
64MP0003635_abnormal_synaptic_transmissio1.11569062
65MP0002733_abnormal_thermal_nociception1.11538757
66MP0002653_abnormal_ependyma_morphology1.11169429
67MP0001919_abnormal_reproductive_system1.10950559
68MP0002184_abnormal_innervation1.09343585
69MP0002234_abnormal_pharynx_morphology1.09318914
70MP0002734_abnormal_mechanical_nocicepti1.05885091
71MP0001293_anophthalmia1.05605060
72MP0002160_abnormal_reproductive_system1.03987364
73MP0002928_abnormal_bile_duct1.03919975
74MP0000026_abnormal_inner_ear1.02562778
75MP0010386_abnormal_urinary_bladder1.02082240
76MP0004924_abnormal_behavior1.00675062
77MP0005386_behavior/neurological_phenoty1.00675062
78MP0000049_abnormal_middle_ear1.00021057
79MP0005195_abnormal_posterior_eye0.99456672
80MP0002751_abnormal_autonomic_nervous0.99171169
81MP0001440_abnormal_grooming_behavior0.99099088
82MP0005174_abnormal_tail_pigmentation0.96003401
83MP0002822_catalepsy0.95987647
84MP0000647_abnormal_sebaceous_gland0.95806209
85MP0002063_abnormal_learning/memory/cond0.93905744
86MP0002752_abnormal_somatic_nervous0.93839378
87MP0002735_abnormal_chemical_nociception0.92687638
88MP0003137_abnormal_impulse_conducting0.88698845
89MP0001501_abnormal_sleep_pattern0.86289694
90MP0000566_synostosis0.82268854
91MP0001963_abnormal_hearing_physiology0.81720331
92MP0003718_maternal_effect0.81572097
93MP0003119_abnormal_digestive_system0.79515422
94MP0002210_abnormal_sex_determination0.77779506
95MP0008995_early_reproductive_senescence0.77326413
96MP0000955_abnormal_spinal_cord0.77022186
97MP0002909_abnormal_adrenal_gland0.76955970
98MP0003890_abnormal_embryonic-extraembry0.76291872
99MP0003937_abnormal_limbs/digits/tail_de0.75309570
100MP0008058_abnormal_DNA_repair0.74442358

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.51027395
2Mitochondrial inheritance (HP:0001427)3.96604509
3Abnormal mitochondria in muscle tissue (HP:0008316)3.87040922
4Progressive macrocephaly (HP:0004481)3.86729397
5Acute encephalopathy (HP:0006846)3.76141399
6Abnormality of midbrain morphology (HP:0002418)3.60926379
7Molar tooth sign on MRI (HP:0002419)3.60926379
8Increased hepatocellular lipid droplets (HP:0006565)3.59284302
9Increased CSF lactate (HP:0002490)3.51070669
10Pancreatic cysts (HP:0001737)3.43789894
11Pancreatic fibrosis (HP:0100732)3.39700972
12True hermaphroditism (HP:0010459)3.33777265
13Congenital stationary night blindness (HP:0007642)3.22633796
14Congenital, generalized hypertrichosis (HP:0004540)3.21353316
15Lipid accumulation in hepatocytes (HP:0006561)3.18736402
16Nephronophthisis (HP:0000090)2.97539582
17Medial flaring of the eyebrow (HP:0010747)2.94691044
18Hepatocellular necrosis (HP:0001404)2.87946384
19Cerebral edema (HP:0002181)2.85200157
20Renal Fanconi syndrome (HP:0001994)2.83053121
21Hepatic necrosis (HP:0002605)2.71341766
223-Methylglutaconic aciduria (HP:0003535)2.63154870
23Optic disc pallor (HP:0000543)2.58713854
24Methylmalonic acidemia (HP:0002912)2.55030088
25Pendular nystagmus (HP:0012043)2.43582300
26Type II lissencephaly (HP:0007260)2.41513186
27Abnormality of the renal cortex (HP:0011035)2.40932309
28Abnormality of the renal medulla (HP:0100957)2.40652971
29Abolished electroretinogram (ERG) (HP:0000550)2.36603052
30Gait imbalance (HP:0002141)2.35439949
31Increased intramyocellular lipid droplets (HP:0012240)2.33589977
32Methylmalonic aciduria (HP:0012120)2.32205439
33Abnormal rod and cone electroretinograms (HP:0008323)2.29829051
34Sclerocornea (HP:0000647)2.28466962
35Exertional dyspnea (HP:0002875)2.27807518
36Limb dystonia (HP:0002451)2.25431884
37Septo-optic dysplasia (HP:0100842)2.21108621
38Congenital primary aphakia (HP:0007707)2.20484301
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20207706
40Abnormal number of erythroid precursors (HP:0012131)2.17292592
41Leukodystrophy (HP:0002415)2.15906234
42Hypothermia (HP:0002045)2.15079098
43Rib fusion (HP:0000902)2.11922291
44Supernumerary spleens (HP:0009799)2.10988912
45Lethargy (HP:0001254)2.10019961
46Nephrogenic diabetes insipidus (HP:0009806)2.07394489
47Abnormality of the labia minora (HP:0012880)2.07080054
48Abnormality of cells of the erythroid lineage (HP:0012130)2.06924999
49Male pseudohermaphroditism (HP:0000037)2.06617815
50Renal cortical cysts (HP:0000803)2.06595381
51Abnormality of renal resorption (HP:0011038)2.06339044
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04925747
53Lactic acidosis (HP:0003128)2.04820793
54Increased serum lactate (HP:0002151)2.03549882
55Abnormal ciliary motility (HP:0012262)2.03541974
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03273667
57Abnormality of alanine metabolism (HP:0010916)2.03273667
58Hyperalaninemia (HP:0003348)2.03273667
59Abnormal respiratory epithelium morphology (HP:0012253)2.02883176
60Abnormal respiratory motile cilium morphology (HP:0005938)2.02883176
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.00884251
62Absent/shortened dynein arms (HP:0200106)2.00884251
63Anencephaly (HP:0002323)2.00541636
64Abnormality of urine glucose concentration (HP:0011016)2.00071145
65Glycosuria (HP:0003076)2.00071145
66Hyperglycinemia (HP:0002154)1.98380467
67Abnormal respiratory motile cilium physiology (HP:0012261)1.95072423
68Focal motor seizures (HP:0011153)1.92007515
69Median cleft lip (HP:0000161)1.89471314
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88801231
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88801231
72Cystic liver disease (HP:0006706)1.87632607
73Polydipsia (HP:0001959)1.87578699
74Abnormal drinking behavior (HP:0030082)1.87578699
75Decreased central vision (HP:0007663)1.86486483
76Genital tract atresia (HP:0001827)1.84863794
77Macrocytic anemia (HP:0001972)1.84742183
78Respiratory failure (HP:0002878)1.83319958
79Short tibia (HP:0005736)1.82541182
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.81557610
81Concave nail (HP:0001598)1.81202924
82Vaginal atresia (HP:0000148)1.80988420
83Postaxial foot polydactyly (HP:0001830)1.80758872
84Attenuation of retinal blood vessels (HP:0007843)1.78939442
85Optic nerve hypoplasia (HP:0000609)1.78487538
86Postaxial hand polydactyly (HP:0001162)1.77776745
87Hypoplasia of the pons (HP:0012110)1.76462032
88Reticulocytopenia (HP:0001896)1.76278649
89Abnormality of the pons (HP:0007361)1.74658085
90Increased muscle lipid content (HP:0009058)1.73455590
91IgG deficiency (HP:0004315)1.71647511
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.71631217
93Tubular atrophy (HP:0000092)1.71275650
94Aplastic anemia (HP:0001915)1.70838748
95Lissencephaly (HP:0001339)1.70580332
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70308610
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69543914
98Furrowed tongue (HP:0000221)1.69431202
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68964213
100Bilateral microphthalmos (HP:0007633)1.67136712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.25980099
2TSSK62.89392013
3ZAK2.53964023
4WEE12.50502502
5FRK2.43289383
6NUAK12.39950293
7ADRBK22.33507016
8WNK32.20679926
9GRK12.07184615
10MAPK152.03766931
11MAP4K21.96088112
12VRK11.95834178
13VRK21.94702740
14CASK1.94521726
15PINK11.93274200
16TXK1.86169409
17TNIK1.78754408
18MAPK131.77804347
19WNK41.70461665
20TLK11.70315207
21TAOK31.60312272
22DYRK21.60028870
23TRIM281.48431608
24BMPR1B1.47812363
25STK161.43488152
26MST41.43150006
27MARK11.33335692
28TAF11.31624313
29INSRR1.29055183
30BCKDK1.27948926
31OXSR11.24999247
32MAP2K71.18636542
33STK391.18429373
34BUB11.14410833
35PLK31.12440676
36CDC71.11539251
37MKNK21.08687015
38BCR1.07293653
39MAP3K41.07015352
40MAP3K121.03387920
41TIE11.01459670
42NTRK20.98939177
43NTRK30.98262035
44PRKCG0.94305412
45NME10.91896943
46ERBB30.89974005
47MAPKAPK50.86580285
48CSNK1G20.85032225
49EPHB20.83414380
50KDR0.81823722
51CDK30.81801709
52SRPK10.78605346
53PLK20.78545599
54CSNK1G30.78130799
55PHKG20.76120530
56PHKG10.76120530
57MAP2K60.73511279
58CSNK1G10.72471449
59EIF2AK30.70988111
60LIMK10.70164170
61PRKCE0.68958520
62PAK30.67773945
63RPS6KA50.67424134
64PIK3CA0.66619888
65MINK10.63735107
66PRKCQ0.62799397
67MKNK10.62709275
68CAMKK20.62306586
69BRSK20.62162976
70NEK10.61366649
71DYRK30.61064675
72PASK0.58411581
73CDK190.58337117
74CSNK1A1L0.57256101
75DAPK20.56805519
76UHMK10.56335182
77TEC0.55695067
78CAMK2A0.54555854
79ADRBK10.53733040
80PRKACA0.53731877
81MUSK0.53580686
82ITK0.53085563
83PLK40.49321404
84PLK10.47905881
85CSNK1A10.46501362
86OBSCN0.43675124
87FES0.42476505
88CSNK2A10.42405880
89ATR0.41625594
90TESK20.40089276
91CSNK2A20.39622616
92PKN10.38702951
93ACVR1B0.38034476
94IKBKB0.37702151
95CSNK1E0.36673725
96PRKG10.36247917
97CAMK2D0.35028835
98TNK20.34786318
99PRKCA0.34326255
100AURKA0.33190705

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.26717272
2Parkinsons disease_Homo sapiens_hsa050123.59231856
3Protein export_Homo sapiens_hsa030603.40025702
4Proteasome_Homo sapiens_hsa030503.13908656
5Ribosome_Homo sapiens_hsa030103.01301419
6Cardiac muscle contraction_Homo sapiens_hsa042602.38391966
7Alzheimers disease_Homo sapiens_hsa050102.37853560
8Huntingtons disease_Homo sapiens_hsa050162.34239957
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19567987
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.13219479
11Phototransduction_Homo sapiens_hsa047442.08824225
12RNA polymerase_Homo sapiens_hsa030202.01242225
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99842335
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98623271
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88564353
16Caffeine metabolism_Homo sapiens_hsa002321.73153853
17Nicotine addiction_Homo sapiens_hsa050331.70998335
18Basal transcription factors_Homo sapiens_hsa030221.66867813
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65710727
20Homologous recombination_Homo sapiens_hsa034401.64302388
21Linoleic acid metabolism_Homo sapiens_hsa005911.51087125
22Butanoate metabolism_Homo sapiens_hsa006501.47293815
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45662841
24RNA degradation_Homo sapiens_hsa030181.43555245
25Propanoate metabolism_Homo sapiens_hsa006401.35744720
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33048223
27Primary immunodeficiency_Homo sapiens_hsa053401.32054787
28Nitrogen metabolism_Homo sapiens_hsa009101.31771053
29Fanconi anemia pathway_Homo sapiens_hsa034601.25673700
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21646819
31Asthma_Homo sapiens_hsa053101.20830002
32Selenocompound metabolism_Homo sapiens_hsa004501.20267230
33Tryptophan metabolism_Homo sapiens_hsa003801.18707524
34Type I diabetes mellitus_Homo sapiens_hsa049401.14744892
35Spliceosome_Homo sapiens_hsa030401.02122113
36Olfactory transduction_Homo sapiens_hsa047401.01633358
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99871254
38Collecting duct acid secretion_Homo sapiens_hsa049660.98440550
39One carbon pool by folate_Homo sapiens_hsa006700.95714081
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.95631931
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95173733
42Taste transduction_Homo sapiens_hsa047420.94424847
43Steroid biosynthesis_Homo sapiens_hsa001000.93096643
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92315806
45Peroxisome_Homo sapiens_hsa041460.91478637
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89162605
47Allograft rejection_Homo sapiens_hsa053300.89145677
48Autoimmune thyroid disease_Homo sapiens_hsa053200.85946216
49Antigen processing and presentation_Homo sapiens_hsa046120.84809771
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84124491
51Chemical carcinogenesis_Homo sapiens_hsa052040.83318309
52Graft-versus-host disease_Homo sapiens_hsa053320.83216681
53Ether lipid metabolism_Homo sapiens_hsa005650.78941972
54Rheumatoid arthritis_Homo sapiens_hsa053230.78487764
55GABAergic synapse_Homo sapiens_hsa047270.78083304
56Morphine addiction_Homo sapiens_hsa050320.77263364
57Purine metabolism_Homo sapiens_hsa002300.76916041
58Insulin secretion_Homo sapiens_hsa049110.76178867
59Regulation of autophagy_Homo sapiens_hsa041400.74788511
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74214196
61Pyrimidine metabolism_Homo sapiens_hsa002400.74072875
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71399012
63Retinol metabolism_Homo sapiens_hsa008300.71039996
64Nucleotide excision repair_Homo sapiens_hsa034200.71020871
65RNA transport_Homo sapiens_hsa030130.70313755
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.67558233
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67309832
68Mismatch repair_Homo sapiens_hsa034300.66898199
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61923469
70Folate biosynthesis_Homo sapiens_hsa007900.61151490
71Metabolic pathways_Homo sapiens_hsa011000.60467964
72beta-Alanine metabolism_Homo sapiens_hsa004100.60274726
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59103630
74Sulfur metabolism_Homo sapiens_hsa009200.59042286
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.57081589
76Glutamatergic synapse_Homo sapiens_hsa047240.53776235
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53699920
78Serotonergic synapse_Homo sapiens_hsa047260.52229098
79Cocaine addiction_Homo sapiens_hsa050300.51844547
80Arachidonic acid metabolism_Homo sapiens_hsa005900.48112819
81Mineral absorption_Homo sapiens_hsa049780.46230494
82Pyruvate metabolism_Homo sapiens_hsa006200.46181427
83Circadian entrainment_Homo sapiens_hsa047130.44973803
84Amphetamine addiction_Homo sapiens_hsa050310.44399634
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43784149
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43445247
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42764123
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42412820
89Fat digestion and absorption_Homo sapiens_hsa049750.40144126
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.40045400
91Ovarian steroidogenesis_Homo sapiens_hsa049130.38636205
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36828626
93Hedgehog signaling pathway_Homo sapiens_hsa043400.35651858
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34017974
95Dopaminergic synapse_Homo sapiens_hsa047280.33528284
96Salivary secretion_Homo sapiens_hsa049700.33188576
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32023243
98Systemic lupus erythematosus_Homo sapiens_hsa053220.29946555
99DNA replication_Homo sapiens_hsa030300.28521084
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26381074

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