HSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phsphorylation, which promotes binding by heat shock protein 90. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.92317604
2transcription from mitochondrial promoter (GO:0006390)7.80366789
3proline metabolic process (GO:0006560)7.29802457
4replication fork processing (GO:0031297)7.11928716
5DNA deamination (GO:0045006)7.07696551
6positive regulation of protein homooligomerization (GO:0032464)6.24180973
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.06372352
8regulation of integrin activation (GO:0033623)5.90799520
9establishment of apical/basal cell polarity (GO:0035089)5.85240790
10oxidative demethylation (GO:0070989)5.84524069
11mitochondrial DNA metabolic process (GO:0032042)5.37560517
12regulation of protein homooligomerization (GO:0032462)5.31876724
13mitotic G1 DNA damage checkpoint (GO:0031571)5.18375439
14somatic hypermutation of immunoglobulin genes (GO:0016446)5.16603805
15somatic diversification of immune receptors via somatic mutation (GO:0002566)5.16603805
16poly(A)+ mRNA export from nucleus (GO:0016973)5.12037789
17DNA strand renaturation (GO:0000733)5.02068590
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.98626240
19establishment of monopolar cell polarity (GO:0061162)4.98626240
20viral mRNA export from host cell nucleus (GO:0046784)4.76734495
21mRNA cleavage (GO:0006379)4.55155105
22mitotic G1/S transition checkpoint (GO:0044819)4.52800726
23Golgi transport vesicle coating (GO:0048200)4.52198616
24COPI coating of Golgi vesicle (GO:0048205)4.52198616
25G1 DNA damage checkpoint (GO:0044783)4.51035466
26negative regulation of cell size (GO:0045792)4.46744476
27regulation of translational fidelity (GO:0006450)4.45624721
28formation of translation preinitiation complex (GO:0001731)4.43881807
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.42861545
30negative regulation of JAK-STAT cascade (GO:0046426)4.38582494
31negative regulation of cell cycle arrest (GO:0071157)4.37061034
32base-excision repair (GO:0006284)4.27670971
33telomere maintenance via semi-conservative replication (GO:0032201)4.21133083
34negative regulation of erythrocyte differentiation (GO:0045647)4.14671139
35cellular response to zinc ion (GO:0071294)4.13394604
36spliceosomal tri-snRNP complex assembly (GO:0000244)4.04279475
37dosage compensation (GO:0007549)3.96420338
38protein retention in ER lumen (GO:0006621)3.90380636
39cellular response to ATP (GO:0071318)3.87102031
40DNA integration (GO:0015074)3.85598704
41mitochondrial RNA metabolic process (GO:0000959)3.85311122
42negative regulation of mRNA processing (GO:0050686)3.84062171
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.83283890
44histone H4-K12 acetylation (GO:0043983)3.79174912
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.73828007
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.73828007
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.73828007
48termination of RNA polymerase II transcription (GO:0006369)3.73389152
49negative regulation of Ras GTPase activity (GO:0034261)3.70168140
50regulation of sister chromatid cohesion (GO:0007063)3.70155561
51positive regulation of protein oligomerization (GO:0032461)3.69923331
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.68227267
53regulation of mammary gland epithelial cell proliferation (GO:0033599)3.67304020
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65977496
55meiotic chromosome segregation (GO:0045132)3.65944428
56glutamine family amino acid biosynthetic process (GO:0009084)3.65108556
57negative regulation of protein oligomerization (GO:0032460)3.63952759
58maturation of 5.8S rRNA (GO:0000460)3.63753608
59regulation of RNA export from nucleus (GO:0046831)3.61646871
60positive regulation by host of viral transcription (GO:0043923)3.61191504
61positive regulation of developmental pigmentation (GO:0048087)3.60835933
62non-recombinational repair (GO:0000726)3.60495394
63double-strand break repair via nonhomologous end joining (GO:0006303)3.60495394
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60391258
65base-excision repair, AP site formation (GO:0006285)3.60278714
66negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.60118955
67apoptotic process involved in morphogenesis (GO:0060561)3.58526738
68embryonic camera-type eye development (GO:0031076)3.52644273
69DNA topological change (GO:0006265)3.51840160
70negative regulation of fatty acid biosynthetic process (GO:0045717)3.51681587
71negative regulation of RNA splicing (GO:0033119)3.49873189
72DNA strand elongation involved in DNA replication (GO:0006271)3.49587035
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.47147509
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.45621928
75trophectodermal cell differentiation (GO:0001829)3.45221638
76regulation of protein oligomerization (GO:0032459)3.45122148
77telomere maintenance via recombination (GO:0000722)3.42399858
78focal adhesion assembly (GO:0048041)3.42272559
79cell-substrate adherens junction assembly (GO:0007045)3.42272559
80barbed-end actin filament capping (GO:0051016)3.38085721
81convergent extension (GO:0060026)3.37640378
82DNA double-strand break processing (GO:0000729)3.36784104
833-UTR-mediated mRNA stabilization (GO:0070935)3.35572403
84kinetochore assembly (GO:0051382)3.35362320
85adherens junction assembly (GO:0034333)3.34012588
86pentose-phosphate shunt (GO:0006098)3.32911189
87face development (GO:0060324)3.31947677
88glial cell migration (GO:0008347)3.30128179
89anatomical structure regression (GO:0060033)3.29678250
90regulation of DNA damage checkpoint (GO:2000001)3.29266423
91DNA strand elongation (GO:0022616)3.28151052
92protein localization to endosome (GO:0036010)3.28069567
93nodal signaling pathway (GO:0038092)3.26509971
94mannose metabolic process (GO:0006013)3.26458994
95DNA demethylation (GO:0080111)3.25168066
96GDP-mannose metabolic process (GO:0019673)3.24699813
97regulation of double-strand break repair (GO:2000779)3.23602743
98peptidyl-arginine omega-N-methylation (GO:0035247)3.20850387
99NIK/NF-kappaB signaling (GO:0038061)3.15867323
100glucose catabolic process (GO:0006007)3.14792633
101negative regulation of necroptotic process (GO:0060546)3.13375969
102modulation by virus of host process (GO:0019054)3.12088018
103positive regulation of chromosome segregation (GO:0051984)3.11080619
104negative regulation of mRNA metabolic process (GO:1903312)3.10683098
105positive regulation of Cdc42 GTPase activity (GO:0043089)3.08455661
106modulation by symbiont of host cellular process (GO:0044068)3.07820687
107mitotic sister chromatid segregation (GO:0000070)3.07626802
108labyrinthine layer development (GO:0060711)3.07259979
109mitochondrial DNA replication (GO:0006264)3.06032966
110* embryonic process involved in female pregnancy (GO:0060136)3.05548254
111positive regulation of DNA repair (GO:0045739)3.05353418
112activation of Rac GTPase activity (GO:0032863)3.04178466
113pinocytosis (GO:0006907)3.04091412
114resolution of meiotic recombination intermediates (GO:0000712)3.03546425
115activation of MAPKKK activity (GO:0000185)3.02796725
116cell-substrate junction assembly (GO:0007044)3.02260178
117pyrimidine nucleotide catabolic process (GO:0006244)3.01886330
118UV protection (GO:0009650)3.01080746
119intracellular estrogen receptor signaling pathway (GO:0030520)3.00864732
120positive regulation of histone deacetylation (GO:0031065)2.98848538
121mRNA export from nucleus (GO:0006406)2.97334081
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.94975923
123mRNA polyadenylation (GO:0006378)2.94586023
124telomere maintenance via telomere lengthening (GO:0010833)2.93938007
125DNA ligation (GO:0006266)2.92797354
126nuclear envelope reassembly (GO:0031468)2.91642071
127mitotic nuclear envelope reassembly (GO:0007084)2.91642071
128regulation of cell size (GO:0008361)2.89218899
129regulation of gene silencing by miRNA (GO:0060964)2.88846250
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87361863
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86811747
132atrioventricular valve morphogenesis (GO:0003181)2.82040586
133regulation of early endosome to late endosome transport (GO:2000641)2.80728710
134NADH metabolic process (GO:0006734)2.79499423
135negative regulation of viral release from host cell (GO:1902187)2.76945391
136stress fiber assembly (GO:0043149)2.72646865
137positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71384005
138thymic T cell selection (GO:0045061)2.70044732
139protein maturation by protein folding (GO:0022417)2.69757854
140maternal placenta development (GO:0001893)2.67781274
141apoptotic process involved in development (GO:1902742)2.64061819
142semaphorin-plexin signaling pathway (GO:0071526)2.63793883
143endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.63450869
144positive regulation of myotube differentiation (GO:0010831)2.62422514
145basement membrane organization (GO:0071711)2.61165018
146regulation of necrotic cell death (GO:0010939)2.60535986
147desmosome organization (GO:0002934)2.58691162
148NADPH regeneration (GO:0006740)2.58688328
149snRNA metabolic process (GO:0016073)2.58279271
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58217236
151modulation by virus of host morphology or physiology (GO:0019048)2.57029464
152regulation of defense response to virus by virus (GO:0050690)2.56824037
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54966052
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.54158908
155regulation of necroptotic process (GO:0060544)2.53441499
156hemidesmosome assembly (GO:0031581)2.52982885
157positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51014931
158amyloid precursor protein catabolic process (GO:0042987)2.48325939
159retrograde transport, endosome to Golgi (GO:0042147)2.48254931
160cellular response to virus (GO:0098586)2.47823512
161positive regulation of nuclease activity (GO:0032075)2.47198501
162negative regulation of necrotic cell death (GO:0060547)2.47057059
163epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47020390
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45922525
165protein targeting to plasma membrane (GO:0072661)2.45802757
166negative regulation of myotube differentiation (GO:0010832)2.45713766
167virion assembly (GO:0019068)2.44149991
168response to muramyl dipeptide (GO:0032495)2.43264032
169protein insertion into membrane (GO:0051205)2.42308995
170positive thymic T cell selection (GO:0045059)2.40368297
171glucose 6-phosphate metabolic process (GO:0051156)2.39070611
172antigen processing and presentation of endogenous antigen (GO:0019883)2.38114180
173epithelial cell-cell adhesion (GO:0090136)2.36814311
174activation of JUN kinase activity (GO:0007257)2.35600788
175ncRNA 3-end processing (GO:0043628)2.33564647
176regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32894491
177positive regulation of protein deacetylation (GO:0090312)2.32412567
178negative regulation of B cell apoptotic process (GO:0002903)2.32171301
179vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31067402
180peptidyl-arginine N-methylation (GO:0035246)2.30739512
181peptidyl-arginine methylation (GO:0018216)2.30739512
182negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30593759
183Arp2/3 complex-mediated actin nucleation (GO:0034314)2.30371654
184positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30279260
185regulation of NFAT protein import into nucleus (GO:0051532)2.29857893
186positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.29691609
187regulation of monocyte differentiation (GO:0045655)2.29079826
188negative regulation of interleukin-2 production (GO:0032703)2.27635943
189antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27150143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.32026450
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.01451458
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.89499488
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85524762
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.82334261
6VDR_21846776_ChIP-Seq_THP-1_Human2.69450279
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.69415059
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64441770
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.49147698
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47619239
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47619239
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47619239
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45683597
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43320562
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.34497827
16MYC_22102868_ChIP-Seq_BL_Human2.32382012
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30688580
18* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.24640793
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16917529
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15230243
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11090684
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98066086
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.97442406
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.92477974
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87309599
26* LXR_22292898_ChIP-Seq_THP-1_Human1.83640691
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80398905
28P68_20966046_ChIP-Seq_HELA_Human1.79149357
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78274269
30POU5F1_16518401_ChIP-PET_MESCs_Mouse1.76745684
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.76281975
32PU.1_20513432_ChIP-Seq_Bcells_Mouse1.71323654
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68717002
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.65255216
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63984989
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62379820
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61939183
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59962383
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56814327
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55897825
41VDR_24763502_ChIP-Seq_THP-1_Human1.55738099
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55659105
43* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55246720
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53862958
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.53507819
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52801884
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51989143
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48786197
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47969585
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46696174
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.45296811
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44959775
53SMC4_20622854_ChIP-Seq_HELA_Human1.44752462
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44176913
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.43525630
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42351882
57KDM2B_26808549_Chip-Seq_K562_Human1.41966711
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.41124762
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40764891
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.39581791
61MAF_26560356_Chip-Seq_TH2_Human1.39560147
62KDM2B_26808549_Chip-Seq_DND41_Human1.39489288
63GABP_19822575_ChIP-Seq_HepG2_Human1.38961146
64UTX_26944678_Chip-Seq_JUKART_Human1.38366127
65BCL6_27268052_Chip-Seq_Bcells_Human1.38295958
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36890255
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.36616716
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36171827
69BCOR_27268052_Chip-Seq_Bcells_Human1.35658451
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35255910
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34889242
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34465668
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34447635
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33933160
75* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33549379
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33401331
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32527000
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32525386
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32202180
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31388576
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31274447
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.29762154
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29693285
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29680136
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28841408
86ZNF263_19887448_ChIP-Seq_K562_Human1.28759144
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28170151
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27803796
89ATF3_27146783_Chip-Seq_COLON_Human1.27119823
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26822100
91XRN2_22483619_ChIP-Seq_HELA_Human1.26810850
92NCOR1_26117541_ChIP-Seq_K562_Human1.26492677
93KDM5A_27292631_Chip-Seq_BREAST_Human1.26428429
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26301484
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.25887245
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25866285
97* ELK3_25401928_ChIP-Seq_HUVEC_Human1.25674106
98* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25242603
99CREB1_26743006_Chip-Seq_LNCaP_Human1.24364616
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23518350
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23321610
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23267652
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22935472
104DCP1A_22483619_ChIP-Seq_HELA_Human1.22839569
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20802096
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20238589
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19999155
108TP53_22127205_ChIP-Seq_IMR90_Human1.19600179
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19441820
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.19310061
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18642195
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18410872
113EGR1_19374776_ChIP-ChIP_THP-1_Human1.18345728
114* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18269469
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18005894
116TCF7_22412390_ChIP-Seq_EML_Mouse1.16953807
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.16881973
118ETS1_21867929_ChIP-Seq_TH2_Mouse1.16712482
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16514420
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15643738
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15490365
122* YY1_21170310_ChIP-Seq_MESCs_Mouse1.15263773
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14670010
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14090772
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14015505
126CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13547019
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13334085
128P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12154702
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10891950
130RARB_24833708_ChIP-Seq_LIVER_Mouse1.10661108
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10633740
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10349767
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08525088
134RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08441367
135CTCF_21964334_Chip-Seq_Bcells_Human1.08016016
136* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07967539
137GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07369362
138TTF2_22483619_ChIP-Seq_HELA_Human1.07053969
139SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04627354
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04576841
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04413053
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04256271
143* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03763975
144CTCF_27219007_Chip-Seq_Bcells_Human1.03403415
145* PHF8_20622854_ChIP-Seq_HELA_Human1.03323072
146TFEB_21752829_ChIP-Seq_HELA_Human1.03251171
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03038237
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02484035
149* ERG_21242973_ChIP-ChIP_JURKAT_Human1.02303863
150* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02080607
151* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01452617
152CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01289266
153SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01220487
154RARA_24833708_ChIP-Seq_LIVER_Mouse1.00879304
155NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00153205
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99857791
157MAF_26560356_Chip-Seq_TH1_Human0.99769047
158SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99358627
159OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97916295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.07330249
2MP0009278_abnormal_bone_marrow4.37064391
3MP0010030_abnormal_orbit_morphology3.78214958
4MP0005451_abnormal_body_composition3.73418950
5MP0005171_absent_coat_pigmentation3.61669980
6MP0004233_abnormal_muscle_weight3.48553090
7MP0008260_abnormal_autophagy3.05765277
8MP0010094_abnormal_chromosome_stability2.79782212
9MP0000751_myopathy2.71826851
10MP0002009_preneoplasia2.61761138
11MP0005397_hematopoietic_system_phenotyp2.60652116
12MP0001545_abnormal_hematopoietic_system2.60652116
13MP0004957_abnormal_blastocyst_morpholog2.40254956
14MP0002877_abnormal_melanocyte_morpholog2.38050838
15MP0001849_ear_inflammation2.34211939
16MP0003283_abnormal_digestive_organ2.23606493
17MP0004858_abnormal_nervous_system2.23580971
18MP0008995_early_reproductive_senescence2.22214237
19MP0002653_abnormal_ependyma_morphology2.18944029
20MP0003436_decreased_susceptibility_to2.16948249
21MP0003111_abnormal_nucleus_morphology2.15362182
22MP0009840_abnormal_foam_cell2.13290371
23MP0003693_abnormal_embryo_hatching2.10344842
24MP0010352_gastrointestinal_tract_polyps2.10049965
25MP0000678_abnormal_parathyroid_gland2.09750585
26MP0003890_abnormal_embryonic-extraembry2.08560510
27MP0003786_premature_aging2.02789793
28MP0004185_abnormal_adipocyte_glucose1.98440007
29MP0005076_abnormal_cell_differentiation1.92881789
30MP0008058_abnormal_DNA_repair1.92656959
31MP0005174_abnormal_tail_pigmentation1.87405671
32MP0003077_abnormal_cell_cycle1.81962239
33MP0004133_heterotaxia1.80068150
34MP0003119_abnormal_digestive_system1.79534108
35MP0002249_abnormal_larynx_morphology1.78724266
36MP0000750_abnormal_muscle_regeneration1.74356301
37MP0003191_abnormal_cellular_cholesterol1.72583256
38MP0008877_abnormal_DNA_methylation1.72211067
39MP0001697_abnormal_embryo_size1.71424993
40MP0002084_abnormal_developmental_patter1.70443800
41MP0000490_abnormal_crypts_of1.66312320
42MP0000858_altered_metastatic_potential1.64912784
43* MP0002086_abnormal_extraembryonic_tissu1.64754336
44MP0004947_skin_inflammation1.61161060
45MP0000003_abnormal_adipose_tissue1.60821429
46MP0006072_abnormal_retinal_apoptosis1.60124622
47MP0008438_abnormal_cutaneous_collagen1.59331794
48MP0003453_abnormal_keratinocyte_physiol1.58114212
49MP0008932_abnormal_embryonic_tissue1.57966734
50MP0000759_abnormal_skeletal_muscle1.56140917
51MP0002085_abnormal_embryonic_tissue1.55274647
52MP0005501_abnormal_skin_physiology1.53671501
53MP0002269_muscular_atrophy1.53662354
54MP0001873_stomach_inflammation1.52821170
55MP0001293_anophthalmia1.52675060
56MP0000733_abnormal_muscle_development1.52144456
57MP0000747_muscle_weakness1.52116854
58MP0004510_myositis1.50744572
59MP0004197_abnormal_fetal_growth/weight/1.49849847
60MP0001672_abnormal_embryogenesis/_devel1.46645161
61MP0005380_embryogenesis_phenotype1.46645161
62MP0003567_abnormal_fetal_cardiomyocyte1.42972341
63MP0004087_abnormal_muscle_fiber1.41641489
64MP0005666_abnormal_adipose_tissue1.41592333
65MP0000350_abnormal_cell_proliferation1.41244348
66MP0005375_adipose_tissue_phenotype1.40503366
67MP0002282_abnormal_trachea_morphology1.39873496
68MP0003172_abnormal_lysosome_physiology1.36520265
69MP0000371_diluted_coat_color1.33332081
70MP0005075_abnormal_melanosome_morpholog1.33275821
71MP0001348_abnormal_lacrimal_gland1.28284806
72MP0000579_abnormal_nail_morphology1.27813729
73MP0005670_abnormal_white_adipose1.27720125
74MP0002396_abnormal_hematopoietic_system1.24595251
75MP0003279_aneurysm1.24325639
76MP0002933_joint_inflammation1.23313640
77MP0003984_embryonic_growth_retardation1.23078756
78MP0000749_muscle_degeneration1.22251859
79MP0003300_gastrointestinal_ulcer1.22194943
80MP0000015_abnormal_ear_pigmentation1.20860539
81MP0002019_abnormal_tumor_incidence1.20790126
82MP0004381_abnormal_hair_follicle1.20474140
83MP0003091_abnormal_cell_migration1.19836688
84MP0000685_abnormal_immune_system1.18619449
85MP0003303_peritoneal_inflammation1.17613634
86MP0002088_abnormal_embryonic_growth/wei1.17613332
87MP0010234_abnormal_vibrissa_follicle1.16164024
88* MP0002080_prenatal_lethality1.15274667
89MP0003828_pulmonary_edema1.14376278
90MP0005058_abnormal_lysosome_morphology1.14243445
91* MP0001730_embryonic_growth_arrest1.10999771
92MP0010307_abnormal_tumor_latency1.08528362
93MP0006138_congestive_heart_failure1.07015723
94MP0003329_amyloid_beta_deposits1.06437032
95MP0000639_abnormal_adrenal_gland1.05157962
96MP0005409_darkened_coat_color1.04823135
97MP0002111_abnormal_tail_morphology1.04212059
98MP0000013_abnormal_adipose_tissue1.01704805
99MP0009333_abnormal_splenocyte_physiolog1.01467953
100MP0009931_abnormal_skin_appearance1.01047123
101MP0004264_abnormal_extraembryonic_tissu1.00906552
102MP0002089_abnormal_postnatal_growth/wei1.00890531
103* MP0005025_abnormal_response_to0.97791892
104MP0000681_abnormal_thyroid_gland0.97631158
105MP0002932_abnormal_joint_morphology0.97169077
106* MP0002060_abnormal_skin_morphology0.94605837
107MP0002075_abnormal_coat/hair_pigmentati0.93623048
108MP0002405_respiratory_system_inflammati0.93362218
109MP0005621_abnormal_cell_physiology0.92441035
110MP0003045_fibrosis0.91063090
111MP0005000_abnormal_immune_tolerance0.90820059
112MP0010630_abnormal_cardiac_muscle0.90604262
113MP0001340_abnormal_eyelid_morphology0.90258262
114MP0003935_abnormal_craniofacial_develop0.89286377
115MP0003656_abnormal_erythrocyte_physiolo0.87347611
116MP0005464_abnormal_platelet_physiology0.87147493
117MP0001216_abnormal_epidermal_layer0.87121463
118MP0002106_abnormal_muscle_physiology0.86208183
119MP0009384_cardiac_valve_regurgitation0.85989641
120MP0002114_abnormal_axial_skeleton0.85934298
121MP0002419_abnormal_innate_immunity0.85792434
122MP0008007_abnormal_cellular_replicative0.84755317
123MP0000467_abnormal_esophagus_morphology0.84616243
124* MP0000313_abnormal_cell_death0.84090128
125MP0002254_reproductive_system_inflammat0.83726124
126MP0003763_abnormal_thymus_physiology0.83397813
127MP0003718_maternal_effect0.82940753
128MP0003806_abnormal_nucleotide_metabolis0.82624852
129MP0005266_abnormal_metabolism0.82550225
130MP0001533_abnormal_skeleton_physiology0.82402326
131MP0004036_abnormal_muscle_relaxation0.81819721
132MP0000767_abnormal_smooth_muscle0.81102609
133MP0005023_abnormal_wound_healing0.81061952
134MP0003075_altered_response_to0.80828230
135MP0009115_abnormal_fat_cell0.80691728
136MP0002398_abnormal_bone_marrow0.80434933
137MP0005330_cardiomyopathy0.80182425
138MP0005083_abnormal_biliary_tract0.80080948
139MP0005257_abnormal_intraocular_pressure0.79774423
140MP0000689_abnormal_spleen_morphology0.77713645
141MP0003755_abnormal_palate_morphology0.77640565
142MP0003566_abnormal_cell_adhesion0.77354432
143MP0001186_pigmentation_phenotype0.76248514
144MP0003137_abnormal_impulse_conducting0.75847261
145MP0002429_abnormal_blood_cell0.75311431
146MP0002420_abnormal_adaptive_immunity0.75236534
147MP0000537_abnormal_urethra_morphology0.75227945
148MP0001819_abnormal_immune_cell0.74957964
149MP0002722_abnormal_immune_system0.74603896
150MP0002148_abnormal_hypersensitivity_rea0.74392133
151MP0002166_altered_tumor_susceptibility0.73859974
152MP0002998_abnormal_bone_remodeling0.73812818
153MP0000762_abnormal_tongue_morphology0.73572529
154MP0004808_abnormal_hematopoietic_stem0.73095409
155MP0010155_abnormal_intestine_physiology0.72495943
156MP0002116_abnormal_craniofacial_bone0.72405279
157MP0005387_immune_system_phenotype0.71274156
158MP0001790_abnormal_immune_system0.71274156
159* MP0000470_abnormal_stomach_morphology0.71142693
160MP0002452_abnormal_antigen_presenting0.70742503
161MP0001661_extended_life_span0.70576399
162MP0009053_abnormal_anal_canal0.70185705
163MP0002796_impaired_skin_barrier0.69763448
164MP0000432_abnormal_head_morphology0.69129587
165MP0004272_abnormal_basement_membrane0.69034279
166MP0005390_skeleton_phenotype0.68846576
167MP0003705_abnormal_hypodermis_morpholog0.67938585
168MP0005508_abnormal_skeleton_morphology0.67680943
169MP0000703_abnormal_thymus_morphology0.67493636
170MP0001784_abnormal_fluid_regulation0.65385259
171MP0000477_abnormal_intestine_morphology0.65292217
172MP0003943_abnormal_hepatobiliary_system0.65265456
173MP0002970_abnormal_white_adipose0.65030759
174MP0002925_abnormal_cardiovascular_devel0.63765320
175MP0002332_abnormal_exercise_endurance0.63548867
176MP0000266_abnormal_heart_morphology0.60737273

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.34264504
2Annular pancreas (HP:0001734)5.12080945
3Pustule (HP:0200039)5.02936618
4Facial hemangioma (HP:0000329)4.92461074
5Concave nail (HP:0001598)4.71532679
6Poikiloderma (HP:0001029)4.68709039
7Rectovaginal fistula (HP:0000143)4.54046402
8Rectal fistula (HP:0100590)4.54046402
9Intestinal fistula (HP:0100819)4.34999452
10Increased IgM level (HP:0003496)4.29537398
11Ulnar bowing (HP:0003031)4.26014761
12Turricephaly (HP:0000262)4.20180017
13Alopecia of scalp (HP:0002293)4.05735474
14Vaginal fistula (HP:0004320)4.02145824
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.97946446
16Tongue fasciculations (HP:0001308)3.92208273
17Male infertility (HP:0003251)3.84082796
18Muscle fibrillation (HP:0010546)3.70878787
19Distal lower limb muscle weakness (HP:0009053)3.69383428
20Short humerus (HP:0005792)3.66347476
21Hypochromic microcytic anemia (HP:0004840)3.63796195
22Increased connective tissue (HP:0009025)3.55537332
23Aplasia/hypoplasia of the humerus (HP:0006507)3.53865179
24Centrally nucleated skeletal muscle fibers (HP:0003687)3.51247025
25Distal lower limb amyotrophy (HP:0008944)3.48945057
26Intestinal atresia (HP:0011100)3.40170611
27Coronal craniosynostosis (HP:0004440)3.39397905
28Hyperacusis (HP:0010780)3.33998886
29Orthostatic hypotension (HP:0001278)3.33698859
30Myopathic facies (HP:0002058)3.28794896
31Absent radius (HP:0003974)3.25222697
32Congenital hip dislocation (HP:0001374)3.23220631
33Abnormal hemoglobin (HP:0011902)3.20132444
34Vertebral hypoplasia (HP:0008417)3.16570001
35Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.16570001
36Basal cell carcinoma (HP:0002671)3.15312874
37Anteriorly placed anus (HP:0001545)3.10812954
38Selective tooth agenesis (HP:0001592)3.09868998
39Achilles tendon contracture (HP:0001771)3.09371769
40Squamous cell carcinoma (HP:0002860)3.08435092
41Exercise-induced myalgia (HP:0003738)3.08353624
42Aplasia involving forearm bones (HP:0009822)3.04539284
43Absent forearm bone (HP:0003953)3.04539284
44Abnormality of male internal genitalia (HP:0000022)3.03626953
45Broad face (HP:0000283)3.03421744
46Absent thumb (HP:0009777)3.00183018
47Ragged-red muscle fibers (HP:0003200)2.97196900
48Mucopolysacchariduria (HP:0008155)2.96396520
49Urinary glycosaminoglycan excretion (HP:0003541)2.96396520
50Short chin (HP:0000331)2.96107925
51Albinism (HP:0001022)2.95287202
52Premature skin wrinkling (HP:0100678)2.91399495
53Patellar aplasia (HP:0006443)2.91194457
54Difficulty climbing stairs (HP:0003551)2.88604408
55Abnormality of the aortic arch (HP:0012303)2.87137063
56Distal upper limb amyotrophy (HP:0007149)2.81170134
57Upper limb amyotrophy (HP:0009129)2.81170134
58Alacrima (HP:0000522)2.80525114
59Broad alveolar ridges (HP:0000187)2.79845182
60Large for gestational age (HP:0001520)2.79676271
61Stridor (HP:0010307)2.78852865
62Cerebral aneurysm (HP:0004944)2.77184896
63Joint stiffness (HP:0001387)2.76643376
64Increased variability in muscle fiber diameter (HP:0003557)2.74306924
65Premature graying of hair (HP:0002216)2.73162430
66Abnormality of polysaccharide metabolism (HP:0011012)2.72261633
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72261633
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72261633
69Abnormality of skeletal muscle fiber size (HP:0012084)2.71845466
70Acute lymphatic leukemia (HP:0006721)2.71114059
71Volvulus (HP:0002580)2.69590249
72Cervical subluxation (HP:0003308)2.67776186
73Aplasia/Hypoplasia of the patella (HP:0006498)2.67012354
74Pancreatic islet-cell hyperplasia (HP:0004510)2.66862239
75Dysostosis multiplex (HP:0000943)2.66833059
76Abnormality of the Achilles tendon (HP:0005109)2.65554694
77Polycythemia (HP:0001901)2.65103314
78Diaphragmatic weakness (HP:0009113)2.64458222
79Dysautonomia (HP:0002459)2.63527309
80Capillary hemangiomas (HP:0005306)2.59158365
81Vertebral compression fractures (HP:0002953)2.58961723
82Bowed forearm bones (HP:0003956)2.57500749
83Bowing of the arm (HP:0006488)2.57500749
84Premature rupture of membranes (HP:0001788)2.57055514
85J-shaped sella turcica (HP:0002680)2.55031241
86Mildly elevated creatine phosphokinase (HP:0008180)2.54822574
87Obstructive sleep apnea (HP:0002870)2.54728591
88Spinal rigidity (HP:0003306)2.52778990
89Cellulitis (HP:0100658)2.50424824
90Growth hormone excess (HP:0000845)2.49741890
91Easy fatigability (HP:0003388)2.46576043
92Hypotelorism (HP:0000601)2.46332940
93Protrusio acetabuli (HP:0003179)2.45620345
94Type 1 muscle fiber predominance (HP:0003803)2.45619806
95IgA deficiency (HP:0002720)2.42127677
96Bifid uvula (HP:0000193)2.38052208
97Hamartoma (HP:0010566)2.37864930
98Hypotrichosis (HP:0001006)2.35524103
99Long palpebral fissure (HP:0000637)2.32287942
100Reticulocytosis (HP:0001923)2.29474626
101Muscle fiber atrophy (HP:0100295)2.29451857
102Hypertensive crisis (HP:0100735)2.29230321
103Hypochromic anemia (HP:0001931)2.27930004
104Asymmetric septal hypertrophy (HP:0001670)2.26609015
105Choanal stenosis (HP:0000452)2.24777399
106Abnormal gallbladder physiology (HP:0012438)2.24360851
107Cholecystitis (HP:0001082)2.24360851
108Lower limb amyotrophy (HP:0007210)2.23221354
109Abnormality of the thoracic spine (HP:0100711)2.20184352
110Progressive muscle weakness (HP:0003323)2.19417829
111Astrocytoma (HP:0009592)2.18519908
112Abnormality of the astrocytes (HP:0100707)2.18519908
113Fragile skin (HP:0001030)2.17580453
114Vertebral fusion (HP:0002948)2.13562671
115Abnormality of the labia minora (HP:0012880)2.13327689
116Increased number of teeth (HP:0011069)2.13252678
117Split hand (HP:0001171)2.13077606
118Generalized amyotrophy (HP:0003700)2.11016896
119Trismus (HP:0000211)2.09979435
120Hemorrhage of the eye (HP:0011885)2.09751552
121Decreased lacrimation (HP:0000633)2.09555355
122Hypoplasia of the radius (HP:0002984)2.09491909
123Colitis (HP:0002583)2.08863622
124Type 2 muscle fiber atrophy (HP:0003554)2.08289335
125Short 5th finger (HP:0009237)2.07322802
126Axonal loss (HP:0003447)2.06613504
127Aplasia of the musculature (HP:0100854)2.06570805
128Narrow nasal bridge (HP:0000446)2.05407056
129Spinal muscular atrophy (HP:0007269)2.02694115
130Bulbar palsy (HP:0001283)2.02638472
131Clumsiness (HP:0002312)2.02450813
132Abnormal number of incisors (HP:0011064)2.02369843
133Rhabdomyolysis (HP:0003201)2.01794292
134Disproportionate tall stature (HP:0001519)2.00881933
135Neoplasm of the oral cavity (HP:0100649)1.98820634
136Gastrointestinal atresia (HP:0002589)1.97526675
137Thoracic kyphosis (HP:0002942)1.94065942
138Flat acetabular roof (HP:0003180)1.93754781
139Hypokinesia (HP:0002375)1.93159288
140Ulnar deviation of the wrist (HP:0003049)1.93070946
141Insomnia (HP:0100785)1.92812221
142Increased serum ferritin (HP:0003281)1.92765185
143Increased cerebral lipofuscin (HP:0011813)1.89179518
144Neck muscle weakness (HP:0000467)1.89122463
145Mitral regurgitation (HP:0001653)1.88837801
146Short nail (HP:0001799)1.88485794
147Hypoplasia of the ulna (HP:0003022)1.88128462
148Hand muscle atrophy (HP:0009130)1.87963498
149Redundant skin (HP:0001582)1.87663354
150Biconcave vertebral bodies (HP:0004586)1.87050479
151Thin bony cortex (HP:0002753)1.86896772
152Hypercortisolism (HP:0001578)1.86506936
153Elbow flexion contracture (HP:0002987)1.86003824
154Popliteal pterygium (HP:0009756)1.84969739
155Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.84847123
156Abnormality of the tricuspid valve (HP:0001702)1.84082594
157Gastrointestinal inflammation (HP:0004386)1.84048389
158Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83851672
159Muscle fiber inclusion bodies (HP:0100299)1.83461860
160Broad hallux (HP:0010055)1.81468173
161Ventricular tachycardia (HP:0004756)1.81118132
162Round ear (HP:0100830)1.80977405
163Increased neuronal autofluorescent lipopigment (HP:0002074)1.79223107
164Broad distal phalanx of finger (HP:0009836)1.78251586
165Hyporeflexia of lower limbs (HP:0002600)1.77975258
166Hyperparathyroidism (HP:0000843)1.77302452
167Hypertriglyceridemia (HP:0002155)1.77299100
168Foot dorsiflexor weakness (HP:0009027)1.74603405
169Truncus arteriosus (HP:0001660)1.69940061
170Flattened epiphyses (HP:0003071)1.69686791
171Muscle stiffness (HP:0003552)1.68355919
172EMG: myopathic abnormalities (HP:0003458)1.68207414
173Nemaline bodies (HP:0003798)1.66956669
174Polygenic inheritance (HP:0010982)1.66781957
175Abnormality of the distal phalanges of the toes (HP:0010182)1.66670138
176Natal tooth (HP:0000695)1.65504341
177Rough bone trabeculation (HP:0100670)1.64608823
178Increased IgE level (HP:0003212)1.64294386
179Interstitial pulmonary disease (HP:0006530)1.63909013
180Abnormality of glycolipid metabolism (HP:0010969)1.62146811
181Abnormality of liposaccharide metabolism (HP:0010968)1.62146811
182Abnormality of glycosphingolipid metabolism (HP:0004343)1.62146811
183Metaphyseal cupping (HP:0003021)1.61257070
184Atelectasis (HP:0100750)1.59346347
185Atrophic scars (HP:0001075)1.58609001
186Microvesicular hepatic steatosis (HP:0001414)1.55955749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.83168132
2MAPK154.99776894
3DDR24.89406860
4MAP3K64.71299217
5MAP3K113.57665375
6SIK13.29341032
7IRAK32.99557375
8PINK12.99411908
9SMG12.94384813
10NME22.89298439
11MATK2.86594788
12TYRO32.82563745
13TESK22.72305467
14FGR2.56312647
15TESK12.40970052
16PIM22.40340473
17PRKD22.36834487
18TTN2.33456474
19BMX2.24467139
20PDGFRA2.16821728
21CSK2.08049259
22UHMK12.03132398
23CDK71.93727054
24DYRK1B1.83879430
25YES11.74689132
26MAP2K31.62842704
27TRPM71.61866355
28LATS21.61422384
29MST1R1.55286545
30PKN21.51699335
31PIM11.46642157
32CDK61.36093766
33MAP3K101.29051028
34CDC42BPA1.27230612
35RPS6KC11.25360443
36RPS6KL11.25360443
37KDR1.22383050
38AKT31.20220883
39TBK11.19140491
40ARAF1.18756464
41IRAK41.16953731
42MAPK111.15853344
43EPHB11.14977959
44RPS6KA61.14758373
45DYRK31.13438685
46CHEK21.13114496
47CDK121.11997605
48MAP3K31.06032065
49TRIB31.03373393
50PRKD31.03234458
51PHKG20.99282814
52PHKG10.99282814
53PTK60.97800694
54TAOK20.97028685
55IRAK20.94946288
56BCKDK0.94159256
57LMTK20.92714415
58LIMK10.91957057
59MTOR0.91572439
60NEK20.89369012
61SIK30.89297455
62RPS6KB20.86766999
63RPS6KA20.86514292
64VRK20.85804844
65HIPK20.85283977
66RAF10.85117717
67MAP3K10.83158988
68CDC70.82847476
69FGFR40.81194979
70TAOK10.81032537
71ZAP700.80350832
72ATR0.78901656
73MAP2K20.78029739
74PRPF4B0.78004964
75MET0.77189754
76GRK60.75205650
77BRAF0.74056747
78WEE10.73950758
79PDPK10.71849914
80* PLK10.70810326
81ILK0.69547365
82MAPK120.69207761
83BUB10.69207072
84RPS6KA10.69145933
85MAP3K130.68315470
86PRKAA10.68289214
87MAPKAPK30.67103912
88SCYL20.63980832
89SIK20.63446660
90LATS10.63330819
91LRRK20.61698027
92MAP4K10.60263868
93MUSK0.56976940
94MAP3K70.56423263
95* CDK20.54698109
96NTRK10.52599589
97KSR20.52320539
98NEK10.47940265
99EEF2K0.47836761
100ABL20.47670182
101STK100.47606147
102TYK20.47173999
103CHEK10.46501559
104FLT30.46453947
105BRSK20.46322567
106STK30.45879175
107CDK40.44024093
108PDGFRB0.43888176
109MAP3K140.42835979
110AURKB0.42741751
111MOS0.42532602
112AURKA0.42370353
113LYN0.41863804
114RPS6KB10.41016599
115CDK80.40310729
116ATM0.39473472
117EGFR0.39319577
118PRKCI0.37164456
119IKBKB0.36736507
120PRKG20.36494504
121CDK90.36355237
122* CSNK2A10.35693108
123PAK40.35460446
124DAPK30.35417040
125* MAPKAPK20.35147398
126JAK30.34839039
127* MAPK10.34691753
128PDK10.34623673
129PTK20.34574953
130NME10.34537775
131ACVR1B0.34183613
132PAK20.33908566
133PRKAA20.33637023
134DMPK0.33561791
135EPHA20.33023797
136ALK0.30383756
137CDK10.30034682
138* MAPK30.29457569
139TNK20.28459150
140ERN10.27751002
141* MAPK140.27697387
142TTK0.27348382
143RIPK10.25756738
144STK380.25303405
145STK38L0.23704602
146* GSK3A0.23523862
147BRSK10.23321097
148MARK20.23221434
149PRKD10.22529756
150MAP3K80.22192344
151PAK10.21528447
152* CSNK2A20.21176537
153CHUK0.19118625
154ERBB30.19000697
155AKT20.18267654
156AKT10.18229024

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.94459013
2Base excision repair_Homo sapiens_hsa034104.76690302
3Fatty acid biosynthesis_Homo sapiens_hsa000614.35644340
4DNA replication_Homo sapiens_hsa030304.20996455
5Other glycan degradation_Homo sapiens_hsa005112.71340789
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50716997
7Nucleotide excision repair_Homo sapiens_hsa034202.41237941
8Spliceosome_Homo sapiens_hsa030402.37442257
9RNA transport_Homo sapiens_hsa030132.32656160
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22118003
11Pentose phosphate pathway_Homo sapiens_hsa000302.11602876
12mRNA surveillance pathway_Homo sapiens_hsa030152.11459900
13Homologous recombination_Homo sapiens_hsa034402.04975205
14Circadian rhythm_Homo sapiens_hsa047102.02871711
15Notch signaling pathway_Homo sapiens_hsa043302.00044396
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99978200
17mTOR signaling pathway_Homo sapiens_hsa041501.99967370
18Cell cycle_Homo sapiens_hsa041101.84216270
19Fanconi anemia pathway_Homo sapiens_hsa034601.81359846
20p53 signaling pathway_Homo sapiens_hsa041151.80936511
21Non-small cell lung cancer_Homo sapiens_hsa052231.73181670
22Hippo signaling pathway_Homo sapiens_hsa043901.65594465
23Hedgehog signaling pathway_Homo sapiens_hsa043401.59093823
24Adherens junction_Homo sapiens_hsa045201.55286127
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52734611
26Biosynthesis of amino acids_Homo sapiens_hsa012301.50442548
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45950677
28Sulfur relay system_Homo sapiens_hsa041221.44162238
29Arginine and proline metabolism_Homo sapiens_hsa003301.44144135
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.42368854
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37991653
32Bladder cancer_Homo sapiens_hsa052191.35395449
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.33748286
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32293898
35TGF-beta signaling pathway_Homo sapiens_hsa043501.25318638
36Shigellosis_Homo sapiens_hsa051311.24182768
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23908267
38Lysine degradation_Homo sapiens_hsa003101.21684008
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20968826
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.16526749
41Prion diseases_Homo sapiens_hsa050201.14339633
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12472482
43Apoptosis_Homo sapiens_hsa042101.11990577
44Primary immunodeficiency_Homo sapiens_hsa053401.11164411
45Carbon metabolism_Homo sapiens_hsa012001.10501610
46VEGF signaling pathway_Homo sapiens_hsa043701.10064278
47Osteoclast differentiation_Homo sapiens_hsa043801.10054360
48Ribosome_Homo sapiens_hsa030101.09793056
49Folate biosynthesis_Homo sapiens_hsa007901.06144468
50Wnt signaling pathway_Homo sapiens_hsa043101.04597701
51Lysosome_Homo sapiens_hsa041421.02417831
52Basal cell carcinoma_Homo sapiens_hsa052171.02301147
53Colorectal cancer_Homo sapiens_hsa052101.00769030
54Hepatitis C_Homo sapiens_hsa051600.99699597
55One carbon pool by folate_Homo sapiens_hsa006700.98372041
56Oocyte meiosis_Homo sapiens_hsa041140.98307402
57Glioma_Homo sapiens_hsa052140.96512231
58Endocytosis_Homo sapiens_hsa041440.95753786
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95100930
60RNA degradation_Homo sapiens_hsa030180.94653277
61Leishmaniasis_Homo sapiens_hsa051400.94572022
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92852440
63TNF signaling pathway_Homo sapiens_hsa046680.92698032
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.90850686
65Fructose and mannose metabolism_Homo sapiens_hsa000510.89433396
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88762167
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.88173555
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.87771815
69Renal cell carcinoma_Homo sapiens_hsa052110.87087527
70Chronic myeloid leukemia_Homo sapiens_hsa052200.85886987
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85547878
72MicroRNAs in cancer_Homo sapiens_hsa052060.85359311
73Insulin resistance_Homo sapiens_hsa049310.84637341
74Acute myeloid leukemia_Homo sapiens_hsa052210.84353167
75Salmonella infection_Homo sapiens_hsa051320.83106051
76Fatty acid metabolism_Homo sapiens_hsa012120.81746623
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.80922313
78Dilated cardiomyopathy_Homo sapiens_hsa054140.80470647
79Toxoplasmosis_Homo sapiens_hsa051450.80270262
80Thyroid cancer_Homo sapiens_hsa052160.75218900
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75081943
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73972898
83Vibrio cholerae infection_Homo sapiens_hsa051100.73333015
84Influenza A_Homo sapiens_hsa051640.73092039
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72823485
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72454621
87Small cell lung cancer_Homo sapiens_hsa052220.72440509
88Viral myocarditis_Homo sapiens_hsa054160.71797967
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.68835069
90Phenylalanine metabolism_Homo sapiens_hsa003600.67402127
91Viral carcinogenesis_Homo sapiens_hsa052030.67107246
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66849241
93T cell receptor signaling pathway_Homo sapiens_hsa046600.66293136
94Herpes simplex infection_Homo sapiens_hsa051680.66023393
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.65957689
96Amoebiasis_Homo sapiens_hsa051460.65324831
97Galactose metabolism_Homo sapiens_hsa000520.63773780
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63180122
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62076223
100RNA polymerase_Homo sapiens_hsa030200.61075850
101Tuberculosis_Homo sapiens_hsa051520.60324085
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.59150481
103Basal transcription factors_Homo sapiens_hsa030220.59060483
104Pertussis_Homo sapiens_hsa051330.59045089
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58648871
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58136815
107HTLV-I infection_Homo sapiens_hsa051660.58061937
108Pyrimidine metabolism_Homo sapiens_hsa002400.57507525
109Malaria_Homo sapiens_hsa051440.57413544
110Insulin signaling pathway_Homo sapiens_hsa049100.57053582
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57039486
112GnRH signaling pathway_Homo sapiens_hsa049120.56273510
113AMPK signaling pathway_Homo sapiens_hsa041520.56244079
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.55469717
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55114514
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54818942
117Epstein-Barr virus infection_Homo sapiens_hsa051690.54248685
118Choline metabolism in cancer_Homo sapiens_hsa052310.54225472
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52883689
120Tight junction_Homo sapiens_hsa045300.52352809
121Inositol phosphate metabolism_Homo sapiens_hsa005620.52067131
122Prolactin signaling pathway_Homo sapiens_hsa049170.51418323
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51088610
124ErbB signaling pathway_Homo sapiens_hsa040120.49825743
125Hepatitis B_Homo sapiens_hsa051610.48660063
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46900112
127Dorso-ventral axis formation_Homo sapiens_hsa043200.42233511
128Proteoglycans in cancer_Homo sapiens_hsa052050.40861001
129Pancreatic cancer_Homo sapiens_hsa052120.40723330
130B cell receptor signaling pathway_Homo sapiens_hsa046620.40178550
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39634671
132Endometrial cancer_Homo sapiens_hsa052130.39250887
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38481445
134Gap junction_Homo sapiens_hsa045400.38213500
135MAPK signaling pathway_Homo sapiens_hsa040100.35650631
136Focal adhesion_Homo sapiens_hsa045100.34137095
137N-Glycan biosynthesis_Homo sapiens_hsa005100.33311240
138HIF-1 signaling pathway_Homo sapiens_hsa040660.31710267
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31617287
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30238877
141Selenocompound metabolism_Homo sapiens_hsa004500.30023401
142Pathways in cancer_Homo sapiens_hsa052000.29999181
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28480126
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.27447669
145Measles_Homo sapiens_hsa051620.24646554
146Non-homologous end-joining_Homo sapiens_hsa034500.24451941
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24088684
148Prostate cancer_Homo sapiens_hsa052150.23820535
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23358617
150Proteasome_Homo sapiens_hsa030500.22604102
151Glutathione metabolism_Homo sapiens_hsa004800.20997880

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