HSDL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase catabolic process (GO:0046113)6.08889330
2negative regulation of dendrite morphogenesis (GO:0050774)5.11529543
3establishment of mitochondrion localization (GO:0051654)4.94095556
4cullin deneddylation (GO:0010388)4.34061874
5neuron recognition (GO:0008038)4.23469268
6positive regulation of mitochondrial fission (GO:0090141)4.17951648
7cell migration in hindbrain (GO:0021535)4.15603826
8protein deneddylation (GO:0000338)4.04040999
9axonal fasciculation (GO:0007413)3.96923815
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92946445
11negative regulation of cell killing (GO:0031342)3.92946445
12negative regulation of dendrite development (GO:2000171)3.90176697
13inositol phosphate catabolic process (GO:0071545)3.84638085
14synapse assembly (GO:0007416)3.74392834
15mitochondrion transport along microtubule (GO:0047497)3.66467651
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.66467651
17viral protein processing (GO:0019082)3.62576624
18positive regulation of dendritic spine morphogenesis (GO:0061003)3.59204266
19calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.51335252
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.48021160
21regulation of isotype switching to IgG isotypes (GO:0048302)3.46113315
22dendrite morphogenesis (GO:0048813)3.45480093
23auditory behavior (GO:0031223)3.39857217
24layer formation in cerebral cortex (GO:0021819)3.38748779
25regulation of synaptic vesicle exocytosis (GO:2000300)3.37810791
26histamine secretion (GO:0001821)3.36706604
27chaperone-mediated protein transport (GO:0072321)3.35865760
28neuron cell-cell adhesion (GO:0007158)3.34160621
29gamma-aminobutyric acid transport (GO:0015812)3.32624577
30transferrin transport (GO:0033572)3.32019692
31synaptic vesicle maturation (GO:0016188)3.28680575
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26837420
33positive regulation of synapse assembly (GO:0051965)3.24221445
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.22290028
35cerebral cortex radially oriented cell migration (GO:0021799)3.21116501
36hippocampus development (GO:0021766)3.18801172
37pyrimidine nucleobase catabolic process (GO:0006208)3.18747715
38protein K11-linked deubiquitination (GO:0035871)3.18155430
39synaptic vesicle exocytosis (GO:0016079)3.17703897
40synaptic transmission, glutamatergic (GO:0035249)3.13086732
41organelle transport along microtubule (GO:0072384)3.10031388
42protein-cofactor linkage (GO:0018065)3.09554536
43negative regulation of oligodendrocyte differentiation (GO:0048715)3.09422693
44nonmotile primary cilium assembly (GO:0035058)3.08440198
45peripheral nervous system neuron development (GO:0048935)3.08399033
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05600857
47regulation of synaptic vesicle transport (GO:1902803)3.04502132
48neural tube formation (GO:0001841)3.03379261
49phagosome maturation (GO:0090382)3.02602001
50positive T cell selection (GO:0043368)3.02312576
51intraciliary transport (GO:0042073)3.01416003
52mechanosensory behavior (GO:0007638)3.00470053
53postsynaptic membrane organization (GO:0001941)2.99695772
54behavioral response to nicotine (GO:0035095)2.99397280
55central nervous system projection neuron axonogenesis (GO:0021952)2.99061084
56vocalization behavior (GO:0071625)2.97969073
57energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.97029429
58ATP hydrolysis coupled proton transport (GO:0015991)2.97029429
59substrate-independent telencephalic tangential migration (GO:0021826)2.96397900
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96397900
61neurofilament cytoskeleton organization (GO:0060052)2.96092787
62dendritic spine morphogenesis (GO:0060997)2.95736003
63trivalent inorganic cation transport (GO:0072512)2.95458786
64ferric iron transport (GO:0015682)2.95458786
65transmission of nerve impulse (GO:0019226)2.94152955
66regulation of synapse structural plasticity (GO:0051823)2.91685763
67negative regulation of microtubule polymerization (GO:0031115)2.91100545
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88715955
69cytoskeleton-dependent intracellular transport (GO:0030705)2.85528006
70positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83017229
71mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83017229
72cerebral cortex cell migration (GO:0021795)2.81577046
73limb bud formation (GO:0060174)2.81435416
74forebrain neuron differentiation (GO:0021879)2.80192570
75synapse organization (GO:0050808)2.78257302
76peptidyl-arginine methylation (GO:0018216)2.78086365
77peptidyl-arginine N-methylation (GO:0035246)2.78086365
78response to auditory stimulus (GO:0010996)2.77878784
79neuron-neuron synaptic transmission (GO:0007270)2.77872503
80short-term memory (GO:0007614)2.77647318
81glutamate receptor signaling pathway (GO:0007215)2.76640274
82regulation of mitochondrial fission (GO:0090140)2.75613000
83axon extension (GO:0048675)2.75498910
84neurotransmitter-gated ion channel clustering (GO:0072578)2.75455691
85negative regulation of mast cell activation (GO:0033004)2.75169330
86serotonin receptor signaling pathway (GO:0007210)2.74630851
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73817221
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72210727
89regulation of NFAT protein import into nucleus (GO:0051532)2.71615895
90positive regulation of gamma-delta T cell activation (GO:0046645)2.71065500
91head development (GO:0060322)2.70899851
92protein localization to microtubule (GO:0035372)2.70855179
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70772625
94neuron migration (GO:0001764)2.70561618
95microtubule-based transport (GO:0010970)2.69999577
96startle response (GO:0001964)2.69837718
97spinal cord development (GO:0021510)2.69727364
98presynaptic membrane assembly (GO:0097105)2.69316484
99heart contraction (GO:0060047)2.68337325
100heart process (GO:0003015)2.68337325
101regulation of development, heterochronic (GO:0040034)2.68083176
102neuron fate determination (GO:0048664)2.67946389
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67210330
104glycosphingolipid biosynthetic process (GO:0006688)2.67093436
105pyrimidine dimer repair (GO:0006290)2.67048603
106retinal ganglion cell axon guidance (GO:0031290)2.66176854
107olfactory bulb development (GO:0021772)2.65653874
108neuronal ion channel clustering (GO:0045161)2.65112781
109positive regulation of amino acid transport (GO:0051957)2.64700801
110GMP metabolic process (GO:0046037)2.63583881
111protein localization to synapse (GO:0035418)2.62434318
112neuronal action potential propagation (GO:0019227)2.61996954
113cytochrome complex assembly (GO:0017004)2.60582906
114negative regulation of homotypic cell-cell adhesion (GO:0034111)2.60401934
115histamine transport (GO:0051608)2.57219371
116dopamine transport (GO:0015872)2.56635546
117protein complex biogenesis (GO:0070271)2.55887208
118glutamate secretion (GO:0014047)2.55730122
119adult walking behavior (GO:0007628)2.55323501
120epithelial cilium movement (GO:0003351)2.52199250
121regulation of relaxation of muscle (GO:1901077)2.51960694
122viral mRNA export from host cell nucleus (GO:0046784)2.51865248
123signal peptide processing (GO:0006465)2.51646139
124regulation of synapse assembly (GO:0051963)2.51486601
125regulation of feeding behavior (GO:0060259)2.51337068
126synaptic vesicle endocytosis (GO:0048488)2.51041211
127vesicle transport along microtubule (GO:0047496)2.50210435
128regulation of dendritic spine morphogenesis (GO:0061001)2.48197067
129protein neddylation (GO:0045116)2.48077255
130ER overload response (GO:0006983)2.47715476
131protein insertion into membrane (GO:0051205)2.47616759
132neuronal action potential (GO:0019228)2.47026811
133regulation of synaptic transmission, GABAergic (GO:0032228)2.46601041
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.46069591
135adenosine metabolic process (GO:0046085)2.45952385
136melanosome transport (GO:0032402)2.44134434
137regulation of glutamate secretion (GO:0014048)2.43777611
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43521170
139striatum development (GO:0021756)2.41617128
140phosphorylated carbohydrate dephosphorylation (GO:0046838)2.40933556
141inositol phosphate dephosphorylation (GO:0046855)2.40933556
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37866025
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37866025
144melanosome localization (GO:0032400)2.34837471
145neurotransmitter secretion (GO:0007269)2.33075249
146positive regulation of cAMP-mediated signaling (GO:0043950)2.31572677
147presynaptic membrane organization (GO:0097090)2.31316581
148synaptic vesicle transport (GO:0048489)2.31291593
149establishment of synaptic vesicle localization (GO:0097480)2.31291593
150regulation of platelet aggregation (GO:0090330)2.31234220
151negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.30957949
152positive regulation of DNA recombination (GO:0045911)2.30826991
153establishment of melanosome localization (GO:0032401)2.30262512
154pigment granule transport (GO:0051904)2.29590245
155respiratory chain complex IV assembly (GO:0008535)2.29205279
156sympathetic nervous system development (GO:0048485)2.26643231
157dopamine receptor signaling pathway (GO:0007212)2.24780107
158de novo posttranslational protein folding (GO:0051084)2.23911446
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.23101104
160regulation of cAMP-dependent protein kinase activity (GO:2000479)2.22959755
161pigment granule localization (GO:0051875)2.22498680
162de novo protein folding (GO:0006458)2.20802901
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.20746593
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.20746593
165NADH dehydrogenase complex assembly (GO:0010257)2.20746593
166ventricular trabecula myocardium morphogenesis (GO:0003222)2.20696768
167protein localization to cilium (GO:0061512)2.19783260
168sequestering of actin monomers (GO:0042989)2.19642920
169regulation of glutamate receptor signaling pathway (GO:1900449)2.19586054
170positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.19167487
171urinary tract smooth muscle contraction (GO:0014848)2.18419507
172dendrite development (GO:0016358)2.18323295
173ribonucleoprotein complex disassembly (GO:0032988)2.18213419
174negative regulation of membrane potential (GO:0045837)2.17688058
175multi-organism localization (GO:1902579)2.17337854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.99275480
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42890190
3GBX2_23144817_ChIP-Seq_PC3_Human3.38430011
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16893200
5TAF15_26573619_Chip-Seq_HEK293_Human3.12850017
6ZNF274_21170338_ChIP-Seq_K562_Hela2.82405227
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56901497
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55457672
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48367460
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24009091
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23607058
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11350269
13EZH2_22144423_ChIP-Seq_EOC_Human2.05968280
14P300_19829295_ChIP-Seq_ESCs_Human2.02528132
15IGF1R_20145208_ChIP-Seq_DFB_Human2.00853204
16* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96314857
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93791569
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83247449
19RNF2_27304074_Chip-Seq_NSC_Mouse1.82571017
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.78212351
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77241802
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76997903
23REST_21632747_ChIP-Seq_MESCs_Mouse1.75087115
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72699967
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.70174039
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69750523
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66906308
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66667717
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.66095465
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.65586758
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63211878
32FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.63170726
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61994488
34SMAD4_21799915_ChIP-Seq_A2780_Human1.61193413
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.61103751
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59599439
37IRF1_19129219_ChIP-ChIP_H3396_Human1.55032812
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.54550530
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54468841
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54162920
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51258433
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.50687415
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50289295
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.50257802
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46907672
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46903531
47JUN_21703547_ChIP-Seq_K562_Human1.44666125
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.42888459
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42848825
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40407785
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38808905
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35005662
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32469235
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31500333
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30590856
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.30227795
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29945723
58EWS_26573619_Chip-Seq_HEK293_Human1.29860632
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.29103760
60AR_25329375_ChIP-Seq_VCAP_Human1.27946286
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26060761
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25696134
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25664039
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.25030462
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24308130
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19823068
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.19424259
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19261609
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17851214
70ER_23166858_ChIP-Seq_MCF-7_Human1.17691048
71ELK1_19687146_ChIP-ChIP_HELA_Human1.17027274
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.16766035
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.16726075
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16665153
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16136451
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15876423
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15571985
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.15396362
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.15228127
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.14636053
81VDR_22108803_ChIP-Seq_LS180_Human1.14153316
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13853343
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12705827
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12554627
85P53_22387025_ChIP-Seq_ESCs_Mouse1.12527808
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12298382
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.10829037
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10807674
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10655710
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10655710
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10207894
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09698670
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09245445
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.08552492
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08276542
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07357524
97VDR_23849224_ChIP-Seq_CD4+_Human1.06642891
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06535566
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06042951
100CBP_20019798_ChIP-Seq_JUKART_Human1.06042951
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05891534
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.05166868
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.05148595
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05043312
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04838808
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04838808
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.04782362
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04318281
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04185374
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.03591004
111FUS_26573619_Chip-Seq_HEK293_Human1.03281131
112SOX9_26525672_Chip-Seq_HEART_Mouse1.03244945
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03063870
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02474929
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02448346
116AR_21572438_ChIP-Seq_LNCaP_Human1.01980275
117REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01788682
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01567295
119* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00700587
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.00453786
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00429378
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.00064395
123JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99011637
124RARB_27405468_Chip-Seq_BRAIN_Mouse0.98851284
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98681242
126RNF2_27304074_Chip-Seq_ESCs_Mouse0.97826945
127NMYC_18555785_Chip-Seq_ESCs_Mouse0.97782984
128TCF4_23295773_ChIP-Seq_U87_Human0.97642221
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96936271
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96886477
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96439829
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.95714878
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94990394
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94371697
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93859653
136STAT3_23295773_ChIP-Seq_U87_Human0.93801356
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93731179
138TP53_22573176_ChIP-Seq_HFKS_Human0.93426847
139AR_19668381_ChIP-Seq_PC3_Human0.93131826
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93050804
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91828984
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88762683
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88577156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.60324766
2MP0002735_abnormal_chemical_nociception3.53386382
3MP0001188_hyperpigmentation3.14512078
4MP0001968_abnormal_touch/_nociception3.01064605
5MP0006276_abnormal_autonomic_nervous2.89771771
6MP0002736_abnormal_nociception_after2.79511036
7MP0003880_abnormal_central_pattern2.77112199
8MP0000015_abnormal_ear_pigmentation2.73682092
9MP0003122_maternal_imprinting2.48354940
10MP0002734_abnormal_mechanical_nocicepti2.41071964
11MP0002102_abnormal_ear_morphology2.38710293
12MP0002876_abnormal_thyroid_physiology2.37222788
13MP0004270_analgesia2.28618900
14MP0005646_abnormal_pituitary_gland2.23904713
15MP0004859_abnormal_synaptic_plasticity2.23107646
16MP0003635_abnormal_synaptic_transmissio2.19758578
17MP0001529_abnormal_vocalization2.19117876
18MP0003787_abnormal_imprinting2.17868922
19MP0002063_abnormal_learning/memory/cond2.07225907
20MP0005645_abnormal_hypothalamus_physiol2.01225171
21MP0004858_abnormal_nervous_system2.00197609
22MP0009745_abnormal_behavioral_response1.99167272
23MP0001984_abnormal_olfaction1.95392564
24MP0004885_abnormal_endolymph1.89390340
25MP0000049_abnormal_middle_ear1.84170994
26MP0000569_abnormal_digit_pigmentation1.83845279
27MP0002572_abnormal_emotion/affect_behav1.78977092
28MP0002733_abnormal_thermal_nociception1.77828716
29MP0009046_muscle_twitch1.76067459
30MP0002064_seizures1.72950016
31MP0002184_abnormal_innervation1.72574577
32MP0003183_abnormal_peptide_metabolism1.72166395
33MP0001970_abnormal_pain_threshold1.64094932
34MP0002272_abnormal_nervous_system1.61374255
35MP0002132_abnormal_respiratory_system1.60410922
36MP0002822_catalepsy1.60109883
37MP0004133_heterotaxia1.58597925
38MP0002234_abnormal_pharynx_morphology1.56013063
39MP0001835_abnormal_antigen_presentation1.54536925
40MP0005671_abnormal_response_to1.49639406
41MP0004147_increased_porphyrin_level1.49500637
42MP0002751_abnormal_autonomic_nervous1.48071153
43MP0004811_abnormal_neuron_physiology1.46052492
44MP0002067_abnormal_sensory_capabilities1.45982293
45MP0003121_genomic_imprinting1.45048114
46MP0000778_abnormal_nervous_system1.41439145
47MP0001905_abnormal_dopamine_level1.40121055
48MP0005187_abnormal_penis_morphology1.36857693
49MP0009785_altered_susceptibility_to1.35085956
50MP0003221_abnormal_cardiomyocyte_apopto1.34763940
51MP0002909_abnormal_adrenal_gland1.34743699
52MP0002152_abnormal_brain_morphology1.33479211
53MP0003861_abnormal_nervous_system1.33234593
54MP0008995_early_reproductive_senescence1.32993270
55MP0002148_abnormal_hypersensitivity_rea1.32309989
56MP0003938_abnormal_ear_development1.31104541
57MP0004510_myositis1.30958143
58MP0003119_abnormal_digestive_system1.30546685
59MP0003890_abnormal_embryonic-extraembry1.30140883
60MP0004782_abnormal_surfactant_physiolog1.28302450
61MP0008569_lethality_at_weaning1.28079686
62MP0008877_abnormal_DNA_methylation1.26922924
63MP0002233_abnormal_nose_morphology1.25725769
64MP0009697_abnormal_copulation1.23887594
65MP0004924_abnormal_behavior1.23316478
66MP0005386_behavior/neurological_phenoty1.23316478
67MP0000372_irregular_coat_pigmentation1.22976479
68MP0002557_abnormal_social/conspecific_i1.21691379
69MP0002163_abnormal_gland_morphology1.21437810
70MP0003937_abnormal_limbs/digits/tail_de1.19974757
71MP0001293_anophthalmia1.18409007
72MP0004142_abnormal_muscle_tone1.18370212
73MP0005171_absent_coat_pigmentation1.15646732
74MP0006072_abnormal_retinal_apoptosis1.15495915
75MP0005409_darkened_coat_color1.14253614
76MP0003763_abnormal_thymus_physiology1.13511291
77MP0008789_abnormal_olfactory_epithelium1.11681503
78MP0004742_abnormal_vestibular_system1.10504805
79MP0000026_abnormal_inner_ear1.07934723
80MP0005499_abnormal_olfactory_system1.07164176
81MP0005394_taste/olfaction_phenotype1.07164176
82MP0005248_abnormal_Harderian_gland1.06000494
83MP0005423_abnormal_somatic_nervous1.05546104
84MP0005253_abnormal_eye_physiology1.04775289
85MP0002095_abnormal_skin_pigmentation1.04420126
86MP0000566_synostosis1.02283230
87MP0008058_abnormal_DNA_repair1.01914354
88MP0003567_abnormal_fetal_cardiomyocyte0.99601673
89MP0001299_abnormal_eye_distance/0.98804581
90MP0001501_abnormal_sleep_pattern0.98736162
91MP0003755_abnormal_palate_morphology0.97463153
92MP0002882_abnormal_neuron_morphology0.94743869
93MP0003943_abnormal_hepatobiliary_system0.94088570
94MP0001486_abnormal_startle_reflex0.91759348
95MP0003385_abnormal_body_wall0.90589188
96MP0000681_abnormal_thyroid_gland0.90222322
97MP0002697_abnormal_eye_size0.89794674
98MP0000955_abnormal_spinal_cord0.89565867
99MP0003136_yellow_coat_color0.88453786
100MP0002638_abnormal_pupillary_reflex0.88231017
101MP0001286_abnormal_eye_development0.87399099
102MP0002653_abnormal_ependyma_morphology0.86027328
103MP0002081_perinatal_lethality0.85905944
104MP0000647_abnormal_sebaceous_gland0.85167598
105MP0005551_abnormal_eye_electrophysiolog0.84446666
106MP0006292_abnormal_olfactory_placode0.84216793
107MP0005174_abnormal_tail_pigmentation0.84197437
108MP0001502_abnormal_circadian_rhythm0.83833808
109MP0005391_vision/eye_phenotype0.83735990
110MP0000749_muscle_degeneration0.83669916
111MP0005195_abnormal_posterior_eye0.82771492
112MP0003879_abnormal_hair_cell0.82127644
113MP0005000_abnormal_immune_tolerance0.81291244
114MP0001919_abnormal_reproductive_system0.80684836
115MP0005075_abnormal_melanosome_morpholog0.80477199
116MP0001485_abnormal_pinna_reflex0.79004480
117MP0002066_abnormal_motor_capabilities/c0.78625266
118MP0001177_atelectasis0.77617841
119MP0006082_CNS_inflammation0.77428634
120MP0000631_abnormal_neuroendocrine_gland0.76847964
121MP0003935_abnormal_craniofacial_develop0.76364411
122MP0003123_paternal_imprinting0.75750149
123MP0008007_abnormal_cellular_replicative0.74864113
124MP0001819_abnormal_immune_cell0.73707071
125MP0004085_abnormal_heartbeat0.73416180
126MP0000678_abnormal_parathyroid_gland0.72726579
127MP0002420_abnormal_adaptive_immunity0.72390843
128MP0001440_abnormal_grooming_behavior0.70759477
129MP0004145_abnormal_muscle_electrophysio0.70393812
130MP0010386_abnormal_urinary_bladder0.70005668
131MP0002177_abnormal_outer_ear0.69828960
132MP0002398_abnormal_bone_marrow0.68719418
133MP0002229_neurodegeneration0.68595777
134MP0002938_white_spotting0.66297775
135MP0002405_respiratory_system_inflammati0.65530638
136MP0005310_abnormal_salivary_gland0.65205761
137MP0001943_abnormal_respiration0.64999579
138MP0005084_abnormal_gallbladder_morpholo0.64485456
139MP0002723_abnormal_immune_serum0.63432413
140MP0005379_endocrine/exocrine_gland_phen0.62467526
141MP0003172_abnormal_lysosome_physiology0.62320837
142MP0001186_pigmentation_phenotype0.60826531
143MP0002752_abnormal_somatic_nervous0.59756219
144MP0002069_abnormal_eating/drinking_beha0.59571417
145MP0001963_abnormal_hearing_physiology0.59149047
146MP0001800_abnormal_humoral_immune0.58126614

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)5.64940973
2Hypothermia (HP:0002045)4.62157720
3Cortical dysplasia (HP:0002539)4.40087433
4Drooling (HP:0002307)3.77414193
5Febrile seizures (HP:0002373)3.76051846
6Focal motor seizures (HP:0011153)3.60933839
7Pheochromocytoma (HP:0002666)3.47041708
8Excessive salivation (HP:0003781)3.43603433
9Nephrogenic diabetes insipidus (HP:0009806)3.42040132
10Neuroendocrine neoplasm (HP:0100634)3.40629795
11Gait imbalance (HP:0002141)3.29318533
12Atonic seizures (HP:0010819)3.13393289
13Congenital primary aphakia (HP:0007707)3.02582551
14Medial flaring of the eyebrow (HP:0010747)2.97748244
15Pachygyria (HP:0001302)2.93993990
16Retinal dysplasia (HP:0007973)2.88096630
17Epileptic encephalopathy (HP:0200134)2.86741854
18Poor coordination (HP:0002370)2.85316548
19Progressive inability to walk (HP:0002505)2.79292770
20Acute necrotizing encephalopathy (HP:0006965)2.79248258
21Urinary urgency (HP:0000012)2.76874118
22Failure to thrive in infancy (HP:0001531)2.75755490
23Amyotrophic lateral sclerosis (HP:0007354)2.69147245
24Severe visual impairment (HP:0001141)2.69104477
25Abnormal mitochondria in muscle tissue (HP:0008316)2.62086282
26Genital tract atresia (HP:0001827)2.61887112
27Poor suck (HP:0002033)2.60612559
28Hepatoblastoma (HP:0002884)2.57338064
29Absent eyebrow (HP:0002223)2.57318611
30Vaginal atresia (HP:0000148)2.52321179
31Increased IgM level (HP:0003496)2.51908217
32Agitation (HP:0000713)2.51311859
33Progressive macrocephaly (HP:0004481)2.48566114
34Abnormality of the corticospinal tract (HP:0002492)2.46575471
35Abnormality of the labia minora (HP:0012880)2.45974709
36Mitochondrial inheritance (HP:0001427)2.42963871
37Limb dystonia (HP:0002451)2.42715222
38Thyroid carcinoma (HP:0002890)2.42396794
39Abnormality of the lower motor neuron (HP:0002366)2.40215787
40Lissencephaly (HP:0001339)2.39577192
41Spastic tetraplegia (HP:0002510)2.38518010
42Hypsarrhythmia (HP:0002521)2.34699287
43Type I transferrin isoform profile (HP:0003642)2.33011311
44Spastic gait (HP:0002064)2.33006963
45Morphological abnormality of the middle ear (HP:0008609)2.31771956
46Hyperventilation (HP:0002883)2.30835270
47Curly hair (HP:0002212)2.30475776
48True hermaphroditism (HP:0010459)2.28049147
49Meningioma (HP:0002858)2.25721540
50Shoulder girdle muscle weakness (HP:0003547)2.25295028
51EEG with generalized epileptiform discharges (HP:0011198)2.25085266
52Amblyopia (HP:0000646)2.24681820
53Absent speech (HP:0001344)2.24184631
54Tongue fasciculations (HP:0001308)2.23536129
55Epileptiform EEG discharges (HP:0011182)2.23255772
56Oligomenorrhea (HP:0000876)2.20912356
57Myokymia (HP:0002411)2.19529372
58Increased CSF lactate (HP:0002490)2.18311786
59Abnormality of glycolysis (HP:0004366)2.16431499
60Increased serum pyruvate (HP:0003542)2.16431499
61Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12162452
62Papillary thyroid carcinoma (HP:0002895)2.12018945
63Neoplasm of the adrenal gland (HP:0100631)2.11809764
64Broad-based gait (HP:0002136)2.10689473
65Nephronophthisis (HP:0000090)2.10207251
66Impaired vibration sensation in the lower limbs (HP:0002166)2.07594803
67Abnormality of T cell number (HP:0011839)2.07288038
68Pendular nystagmus (HP:0012043)2.07269210
69Abnormality of the musculature of the pelvis (HP:0001469)2.06991027
70Abnormality of the hip-girdle musculature (HP:0001445)2.06991027
71Abnormal eating behavior (HP:0100738)2.06262911
72Hypoplasia of the corpus callosum (HP:0002079)2.04585631
73Specific learning disability (HP:0001328)2.03490065
74Fetal akinesia sequence (HP:0001989)2.03174546
75Pancreatic fibrosis (HP:0100732)2.03113438
76Split foot (HP:0001839)2.02255827
77Focal seizures (HP:0007359)2.01889435
78Polyphagia (HP:0002591)2.01145835
79Postaxial hand polydactyly (HP:0001162)2.01002761
80Neoplasm of the peripheral nervous system (HP:0100007)2.00769648
81Optic nerve hypoplasia (HP:0000609)2.00426877
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.00417925
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00417925
84T lymphocytopenia (HP:0005403)1.99560331
85Thyroid-stimulating hormone excess (HP:0002925)1.97269987
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.96503387
87Progressive cerebellar ataxia (HP:0002073)1.94252328
88Polymicrogyria (HP:0002126)1.93738388
89Molar tooth sign on MRI (HP:0002419)1.92946594
90Abnormality of midbrain morphology (HP:0002418)1.92946594
91Urinary bladder sphincter dysfunction (HP:0002839)1.92923612
92Pancreatic cysts (HP:0001737)1.92737376
93Generalized aminoaciduria (HP:0002909)1.91511371
94Short tibia (HP:0005736)1.90990857
95Akinesia (HP:0002304)1.88926358
96Intestinal atresia (HP:0011100)1.88876807
97Broad alveolar ridges (HP:0000187)1.88572747
98Absence seizures (HP:0002121)1.87679910
99Micropenis (HP:0000054)1.87237997
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87177556
101Hypoplasia of the brainstem (HP:0002365)1.87177556
102Oligodactyly (hands) (HP:0001180)1.87161926
103Hip dysplasia (HP:0001385)1.87101148
104Decreased testicular size (HP:0008734)1.86212159
105Narrow forehead (HP:0000341)1.86101153
106Broad foot (HP:0001769)1.83825031
107Visual hallucinations (HP:0002367)1.82786845
108Inability to walk (HP:0002540)1.82221299
109Alveolar cell carcinoma (HP:0006519)1.81890439
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.81784968
111Abnormality of salivation (HP:0100755)1.81673076
112Type 2 muscle fiber atrophy (HP:0003554)1.81605295
113Lower limb muscle weakness (HP:0007340)1.80968880
114Vitreoretinal degeneration (HP:0000655)1.80184185
115Protruding tongue (HP:0010808)1.80034950
116Type II lissencephaly (HP:0007260)1.79516681
117Respiratory difficulties (HP:0002880)1.79435689
118Dialeptic seizures (HP:0011146)1.79300053
119Hyperglycinemia (HP:0002154)1.78390489
120Impaired pain sensation (HP:0007328)1.78132321
121Abnormality of pain sensation (HP:0010832)1.78132321
122Morphological abnormality of the pyramidal tract (HP:0002062)1.77454417
123Hepatocellular necrosis (HP:0001404)1.77412237
124Absent eyelashes (HP:0000561)1.75818643
125Postaxial foot polydactyly (HP:0001830)1.75555850
126Truncal ataxia (HP:0002078)1.74332148
127Muscle fibrillation (HP:0010546)1.73078324
128Heterochromia iridis (HP:0001100)1.72911416
129Exercise-induced muscle cramps (HP:0003710)1.72262823
130Acute encephalopathy (HP:0006846)1.71607056
131Abnormality of the metopic suture (HP:0005556)1.71035015
132Fibular aplasia (HP:0002990)1.71002790
133Muscular hypotonia of the trunk (HP:0008936)1.69811535
134Peripheral hypomyelination (HP:0007182)1.69764559
135Esotropia (HP:0000565)1.69618461
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68915341
137Exotropia (HP:0000577)1.68617659
138Abnormality of the vocal cords (HP:0008777)1.68575483
139Chronic hepatic failure (HP:0100626)1.68554421
140Abnormality of the renal medulla (HP:0100957)1.68286213
141Neuroblastic tumors (HP:0004376)1.67652554
142Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.67652554
143Neuroblastoma (HP:0003006)1.67652554
144Primitive neuroectodermal tumor (HP:0030065)1.67652554
145Ankle clonus (HP:0011448)1.65505914
146Sleep apnea (HP:0010535)1.65061050
147Abnormality of the anterior horn cell (HP:0006802)1.62885904
148Degeneration of anterior horn cells (HP:0002398)1.62885904
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62737070
150Abnormality of alanine metabolism (HP:0010916)1.62737070
151Hyperalaninemia (HP:0003348)1.62737070
152B lymphocytopenia (HP:0010976)1.62679780
153Abnormality of B cell number (HP:0010975)1.62679780
154Unsteady gait (HP:0002317)1.61342819
155Aqueductal stenosis (HP:0002410)1.60311403
156Generalized tonic-clonic seizures (HP:0002069)1.60216938
157Bifid tongue (HP:0010297)1.60164427
158Scrotal hypoplasia (HP:0000046)1.60162771
159Thyroiditis (HP:0100646)1.59086271
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.58908205
161Bradycardia (HP:0001662)1.58338528
162Tinnitus (HP:0000360)1.57782233
163Generalized hypotonia (HP:0001290)1.57609806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.44382314
2CASK4.51370392
3AKT34.02013694
4MAP3K123.79566200
5TRIM283.14031104
6MARK12.60572645
7PRPF4B2.50594508
8SGK22.50254502
9MAP2K72.45744511
10CDK192.38570980
11MINK12.22344867
12BCR2.17594628
13MAPK132.11408368
14SRPK12.00860280
15CSNK1G21.95950339
16PLK21.90068111
17NTRK31.87065704
18EPHA31.84722984
19SGK2231.83711418
20SGK4941.83711418
21TNIK1.82998336
22MAP3K141.82839360
23YES11.78827433
24ERBB31.77735610
25MAP4K21.71337958
26TSSK61.67149524
27CSNK1G31.65601607
28CSNK1A1L1.60526290
29PINK11.60221825
30TXK1.59509151
31MAP3K41.56238717
32LIMK11.55956123
33UHMK11.53848932
34EPHA41.53193182
35BMPR1B1.49156276
36CSNK1G11.47309093
37MYLK1.47073424
38RPS6KA41.46990818
39SGK31.43504019
40BRSK21.42639075
41ADRBK21.39727108
42BRSK11.39603998
43SIK21.37410971
44DYRK21.35448267
45BRAF1.35438698
46DYRK31.34075471
47BMPR21.31200008
48KSR11.30787621
49DAPK11.21347320
50DYRK1B1.20228581
51STK161.12354203
52CCNB11.09354471
53CAMKK21.09299002
54STK241.07747286
55NTRK11.07178169
56MAP3K61.07137928
57PNCK1.04488828
58EPHB21.04052244
59RPS6KA21.01027954
60PAK30.97494928
61ZAK0.95907107
62CDK140.94500271
63CDK80.90609459
64OBSCN0.90386123
65PAK60.89966068
66BCKDK0.88795765
67VRK10.84389791
68SYK0.84068538
69GRK70.83873425
70PLK30.83850804
71GRK50.79978651
72CDK11A0.79856935
73TNK20.78523513
74CDK150.77528411
75RPS6KB10.73974086
76PRKD30.73244006
77PRKCG0.71343656
78NTRK20.69557969
79RIPK40.68727935
80RPS6KC10.67686079
81RPS6KL10.67686079
82TESK10.66682495
83TYRO30.66045833
84RPS6KA60.65393717
85WNK40.65339226
86CAMK2B0.63628861
87BRD40.63019466
88MARK30.61530851
89PKN20.61352540
90MST40.59478620
91PIM20.58694326
92PRKCE0.58545168
93MAP3K90.58428030
94CDC70.55752402
95ITK0.53468698
96PHKG10.52573259
97PHKG20.52573259
98EIF2AK20.52305052
99MAP2K40.50431819
100ADRBK10.50419033
101STK38L0.49578955
102PRKCH0.49174905
103CSNK1E0.48846840
104ARAF0.48563985
105CDK30.48518108
106CSNK1D0.48379035
107PRKCZ0.46921394
108CDK50.46906000
109MKNK20.46878546
110DAPK20.46863658
111TEC0.44533582
112CAMK40.41852807
113PKN10.41585435
114PRKACB0.40577557
115CHUK0.38836773
116IRAK40.38629943
117CAMK2A0.37983205
118CDK180.36677405
119WNK30.36318782
120ACVR1B0.35991509
121MKNK10.35962897
122MAPK90.35677884
123IKBKE0.34158887
124PRKAA10.33798458
125MAP4K10.33732424
126CSNK1A10.33532955
127DYRK1A0.31174396
128BTK0.30876733
129NEK90.30820322
130PRKCD0.29454466
131SGK10.29151814
132PLK10.28706091
133ERBB20.28626020
134MATK0.26990387
135RPS6KA50.26807911
136PRKDC0.26368096
137MAP3K50.25912145
138MAPK40.25389848
139PRKCQ0.25232811
140CLK10.24616564
141PRKG10.24526505
142PRKCB0.24511014
143LCK0.23937898
144CAMK2G0.23936307
145IKBKB0.23931985
146ATM0.23852388
147MAP2K10.23726660
148EIF2AK30.23474296
149RPS6KA30.23220654
150NEK10.22887777
151FER0.22818592
152CAMK2D0.22669090
153MAPK100.22557559
154MAP2K60.22443204
155RET0.22198926
156ZAP700.21916845
157MAPK30.21613842
158GSK3B0.21093543
159PRKACA0.18438621

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.10162980
2Collecting duct acid secretion_Homo sapiens_hsa049662.78538917
3Proteasome_Homo sapiens_hsa030502.59401761
4Steroid biosynthesis_Homo sapiens_hsa001002.54410721
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24871002
6Oxidative phosphorylation_Homo sapiens_hsa001902.21517075
7Parkinsons disease_Homo sapiens_hsa050121.96913080
8Type I diabetes mellitus_Homo sapiens_hsa049401.94339200
9Vibrio cholerae infection_Homo sapiens_hsa051101.91339196
10Nicotine addiction_Homo sapiens_hsa050331.90660725
11Protein export_Homo sapiens_hsa030601.90038537
12Olfactory transduction_Homo sapiens_hsa047401.84784048
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81186107
14Rheumatoid arthritis_Homo sapiens_hsa053231.75862300
15Allograft rejection_Homo sapiens_hsa053301.64239599
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63688438
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58782397
18Serotonergic synapse_Homo sapiens_hsa047261.55906570
19Morphine addiction_Homo sapiens_hsa050321.53897740
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.53402574
21Phagosome_Homo sapiens_hsa041451.52278544
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51568278
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50688745
24Butanoate metabolism_Homo sapiens_hsa006501.50347951
25Primary immunodeficiency_Homo sapiens_hsa053401.48108610
26Dopaminergic synapse_Homo sapiens_hsa047281.44647007
27GABAergic synapse_Homo sapiens_hsa047271.39192361
28Huntingtons disease_Homo sapiens_hsa050161.37145774
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35980022
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29144366
31Alzheimers disease_Homo sapiens_hsa050101.28363982
32Phototransduction_Homo sapiens_hsa047441.26253310
33Circadian entrainment_Homo sapiens_hsa047131.23986149
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22706697
35Autoimmune thyroid disease_Homo sapiens_hsa053201.21622052
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19642020
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19342963
38Taste transduction_Homo sapiens_hsa047421.18569600
39Long-term potentiation_Homo sapiens_hsa047201.16224208
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11873226
41Gap junction_Homo sapiens_hsa045401.10795216
42Regulation of autophagy_Homo sapiens_hsa041401.10539351
43Cardiac muscle contraction_Homo sapiens_hsa042601.09795025
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04305243
45Graft-versus-host disease_Homo sapiens_hsa053321.02556696
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02480543
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02107937
48Hippo signaling pathway_Homo sapiens_hsa043901.00286532
49Hedgehog signaling pathway_Homo sapiens_hsa043400.98600879
50Cholinergic synapse_Homo sapiens_hsa047250.98063381
51mRNA surveillance pathway_Homo sapiens_hsa030150.96211057
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95889523
53Amphetamine addiction_Homo sapiens_hsa050310.91772732
54Non-homologous end-joining_Homo sapiens_hsa034500.91503082
55Insulin secretion_Homo sapiens_hsa049110.90905259
56Legionellosis_Homo sapiens_hsa051340.90829247
57T cell receptor signaling pathway_Homo sapiens_hsa046600.90727712
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90044835
59Epstein-Barr virus infection_Homo sapiens_hsa051690.89488587
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85567847
61Measles_Homo sapiens_hsa051620.85524023
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.85211283
63Endometrial cancer_Homo sapiens_hsa052130.83907760
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83478160
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83377911
66RNA polymerase_Homo sapiens_hsa030200.81906211
67Propanoate metabolism_Homo sapiens_hsa006400.81609908
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81326831
69Basal cell carcinoma_Homo sapiens_hsa052170.79695016
70Glutamatergic synapse_Homo sapiens_hsa047240.79388998
71Basal transcription factors_Homo sapiens_hsa030220.78926463
72Long-term depression_Homo sapiens_hsa047300.77095186
73Thyroid cancer_Homo sapiens_hsa052160.74460915
74Selenocompound metabolism_Homo sapiens_hsa004500.74359785
75Leishmaniasis_Homo sapiens_hsa051400.73895145
76RNA transport_Homo sapiens_hsa030130.71679560
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71424561
78Chemokine signaling pathway_Homo sapiens_hsa040620.70997253
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70174173
80Colorectal cancer_Homo sapiens_hsa052100.69725169
81Circadian rhythm_Homo sapiens_hsa047100.66864014
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66252898
83Wnt signaling pathway_Homo sapiens_hsa043100.66234809
84Tuberculosis_Homo sapiens_hsa051520.65561225
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65127514
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64907010
87Calcium signaling pathway_Homo sapiens_hsa040200.64772078
88Type II diabetes mellitus_Homo sapiens_hsa049300.64182064
89Spliceosome_Homo sapiens_hsa030400.64152857
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63420262
91Cocaine addiction_Homo sapiens_hsa050300.62827617
92Influenza A_Homo sapiens_hsa051640.62706940
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62646570
94Biosynthesis of amino acids_Homo sapiens_hsa012300.60783264
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.60616300
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60232507
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59874558
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59836902
99Fanconi anemia pathway_Homo sapiens_hsa034600.59816308
100Homologous recombination_Homo sapiens_hsa034400.58546352
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58382766
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58265965
103Fatty acid elongation_Homo sapiens_hsa000620.58180326
104Salmonella infection_Homo sapiens_hsa051320.57911365
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57649264
106Melanogenesis_Homo sapiens_hsa049160.57158549
107AMPK signaling pathway_Homo sapiens_hsa041520.56876946
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55715596
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54886178
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54821144
111Asthma_Homo sapiens_hsa053100.54387063
112ErbB signaling pathway_Homo sapiens_hsa040120.53788593
113cAMP signaling pathway_Homo sapiens_hsa040240.53141051
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53047918
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52652394
116Axon guidance_Homo sapiens_hsa043600.51522371
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51163735
118Base excision repair_Homo sapiens_hsa034100.50874591
119Tight junction_Homo sapiens_hsa045300.50400376
120Prolactin signaling pathway_Homo sapiens_hsa049170.48621229
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48592452
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48166898
123Ras signaling pathway_Homo sapiens_hsa040140.47983256
124Ether lipid metabolism_Homo sapiens_hsa005650.47883730
125Fatty acid metabolism_Homo sapiens_hsa012120.47722479
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47657910
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47241720
128RNA degradation_Homo sapiens_hsa030180.46224830
129Oocyte meiosis_Homo sapiens_hsa041140.46191219
130Hematopoietic cell lineage_Homo sapiens_hsa046400.45641893
131Peroxisome_Homo sapiens_hsa041460.45334421
132MAPK signaling pathway_Homo sapiens_hsa040100.44916048
133Shigellosis_Homo sapiens_hsa051310.44178027
134Melanoma_Homo sapiens_hsa052180.43992066
135Antigen processing and presentation_Homo sapiens_hsa046120.43891985
136Oxytocin signaling pathway_Homo sapiens_hsa049210.43131596
137Renin secretion_Homo sapiens_hsa049240.42976346
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42918461
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42035734
140Fatty acid biosynthesis_Homo sapiens_hsa000610.41186200
141Alcoholism_Homo sapiens_hsa050340.40792226
142Dilated cardiomyopathy_Homo sapiens_hsa054140.40746787
143N-Glycan biosynthesis_Homo sapiens_hsa005100.40639619
144Nucleotide excision repair_Homo sapiens_hsa034200.39402687
145Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39107538
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38235049
147FoxO signaling pathway_Homo sapiens_hsa040680.37631052
148Gastric acid secretion_Homo sapiens_hsa049710.37555627
149Purine metabolism_Homo sapiens_hsa002300.36765290
150B cell receptor signaling pathway_Homo sapiens_hsa046620.33859515
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33596720
152Arginine and proline metabolism_Homo sapiens_hsa003300.33463144
153beta-Alanine metabolism_Homo sapiens_hsa004100.32862418
154Rap1 signaling pathway_Homo sapiens_hsa040150.30295163

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