HSD3B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1C21-steroid hormone metabolic process (GO:0008207)9.29417547
2cellular response to gonadotropin stimulus (GO:0071371)8.99759428
3cellular response to antibiotic (GO:0071236)8.86170393
4progesterone metabolic process (GO:0042448)8.78569794
5estrogen biosynthetic process (GO:0006703)8.73022771
6response to follicle-stimulating hormone (GO:0032354)8.58590566
7cellular response to epinephrine stimulus (GO:0071872)7.98499803
8indolalkylamine catabolic process (GO:0046218)7.02311763
9tryptophan catabolic process (GO:0006569)7.02311763
10indole-containing compound catabolic process (GO:0042436)7.02311763
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.98185546
12L-phenylalanine catabolic process (GO:0006559)6.98185546
13aromatic amino acid family catabolic process (GO:0009074)6.94577894
14response to insecticide (GO:0017085)6.72661685
15* hormone biosynthetic process (GO:0042446)6.66021090
16cellular response to toxic substance (GO:0097237)6.60364677
17tryptophan metabolic process (GO:0006568)6.60270310
18response to epinephrine (GO:0071871)6.59168763
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56266453
20L-phenylalanine metabolic process (GO:0006558)6.56266453
21positive regulation of hormone biosynthetic process (GO:0046886)6.53366000
22response to gonadotropin (GO:0034698)6.40401213
23detection of molecule of bacterial origin (GO:0032490)6.17077785
24kynurenine metabolic process (GO:0070189)5.97765414
25ketone biosynthetic process (GO:0042181)5.91650187
26glyoxylate metabolic process (GO:0046487)5.88792648
27response to corticosterone (GO:0051412)5.74318901
28Leydig cell differentiation (GO:0033327)5.63685329
29positive regulation of male gonad development (GO:2000020)5.41403680
30bile acid biosynthetic process (GO:0006699)5.38728103
31homocysteine metabolic process (GO:0050667)5.34555312
32drug transmembrane transport (GO:0006855)5.33290985
33cellular response to growth hormone stimulus (GO:0071378)5.32549125
34cellular response to cadmium ion (GO:0071276)5.25399315
35regulation of female receptivity (GO:0045924)5.21906820
36urate metabolic process (GO:0046415)5.20874358
37low-density lipoprotein particle clearance (GO:0034383)5.20255628
38amine catabolic process (GO:0009310)5.18841799
39cellular biogenic amine catabolic process (GO:0042402)5.18841799
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.17889722
41amyloid precursor protein catabolic process (GO:0042987)5.16291495
42response to methylmercury (GO:0051597)5.16180607
43cellular response to interferon-alpha (GO:0035457)5.14035085
44toxin metabolic process (GO:0009404)5.12591278
45indolalkylamine metabolic process (GO:0006586)5.09901364
46aromatic amino acid family metabolic process (GO:0009072)5.00625224
47cysteine metabolic process (GO:0006534)4.96152794
48* androgen metabolic process (GO:0008209)4.95172830
49regulation of transmission of nerve impulse (GO:0051969)4.92101024
50urea metabolic process (GO:0019627)4.88863320
51urea cycle (GO:0000050)4.88863320
52regulation of transforming growth factor beta2 production (GO:0032909)4.84969607
53lysine catabolic process (GO:0006554)4.82058085
54lysine metabolic process (GO:0006553)4.82058085
55serine family amino acid catabolic process (GO:0009071)4.75228819
56response to water (GO:0009415)4.75005765
57positive regulation of hormone metabolic process (GO:0032352)4.73398130
58drug catabolic process (GO:0042737)4.70322935
59regulation of apoptotic cell clearance (GO:2000425)4.69180029
60response to mineralocorticoid (GO:0051385)4.63955621
61female mating behavior (GO:0060180)4.57667270
62bile acid metabolic process (GO:0008206)4.56523811
63complement activation, alternative pathway (GO:0006957)4.54203393
64exogenous drug catabolic process (GO:0042738)4.52958363
65cellular glucuronidation (GO:0052695)4.48581532
66nitrogen cycle metabolic process (GO:0071941)4.47374481
67regulation of protein activation cascade (GO:2000257)4.46943294
68amino-acid betaine metabolic process (GO:0006577)4.46603756
69alpha-amino acid catabolic process (GO:1901606)4.38913001
70coenzyme catabolic process (GO:0009109)4.34810818
71positive regulation of triglyceride biosynthetic process (GO:0010867)4.33486699
72drug transport (GO:0015893)4.32775411
73sulfur amino acid catabolic process (GO:0000098)4.31939459
74peptidyl-glutamic acid carboxylation (GO:0017187)4.31889208
75protein carboxylation (GO:0018214)4.31889208
76tyrosine metabolic process (GO:0006570)4.31277142
77triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.31234473
78adhesion of symbiont to host (GO:0044406)4.30741476
79aggressive behavior (GO:0002118)4.24759302
80regulation of complement activation (GO:0030449)4.22567462
81glucuronate metabolic process (GO:0019585)4.21688694
82uronic acid metabolic process (GO:0006063)4.21688694
83membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.20465437
84regulation of male gonad development (GO:2000018)4.20311547
85regulation of bile acid biosynthetic process (GO:0070857)4.17561168
86NAD biosynthetic process (GO:0009435)4.14323952
87regulation of fibrinolysis (GO:0051917)4.12186256
88positive regulation of nitric-oxide synthase activity (GO:0051000)4.10785802
89regulation of cholesterol storage (GO:0010885)4.08462995
90positive regulation of steroid biosynthetic process (GO:0010893)4.07342444
91benzene-containing compound metabolic process (GO:0042537)4.06422467
92high-density lipoprotein particle remodeling (GO:0034375)4.04066456
93cellular amino acid catabolic process (GO:0009063)4.02445484
94response to leptin (GO:0044321)4.01487133
95cellular modified amino acid catabolic process (GO:0042219)4.00751397
96imidazole-containing compound metabolic process (GO:0052803)3.98611360
97acylglycerol homeostasis (GO:0055090)3.97345859
98triglyceride homeostasis (GO:0070328)3.97345859
99positive regulation of amino acid transport (GO:0051957)3.95229418
100bile acid and bile salt transport (GO:0015721)3.93993615
101cellular response to monoamine stimulus (GO:0071868)3.93274601
102cellular response to catecholamine stimulus (GO:0071870)3.93274601
103regulation of steroid hormone biosynthetic process (GO:0090030)3.91853848
104negative regulation of cytosolic calcium ion concentration (GO:0051481)3.90992974
105short-chain fatty acid metabolic process (GO:0046459)3.89792469
106alpha-linolenic acid metabolic process (GO:0036109)3.88707770
107negative regulation of fibrinolysis (GO:0051918)3.85563417
108indole-containing compound metabolic process (GO:0042430)3.82955614
109estrogen metabolic process (GO:0008210)3.82804492
110glutamate metabolic process (GO:0006536)3.77821686
111pyridine nucleotide biosynthetic process (GO:0019363)3.74325433
112nicotinamide nucleotide biosynthetic process (GO:0019359)3.74325433
113cholesterol catabolic process (GO:0006707)3.69269720
114sterol catabolic process (GO:0016127)3.69269720
115serine family amino acid metabolic process (GO:0009069)3.68836907
116membrane repolarization during action potential (GO:0086011)3.67423265
117cellular ketone body metabolic process (GO:0046950)3.65859512
118response to lead ion (GO:0010288)3.65580563
119dicarboxylic acid biosynthetic process (GO:0043650)3.64734399
120opsonization (GO:0008228)3.62561723
121atrial cardiac muscle cell action potential (GO:0086014)3.60201410
122aldehyde catabolic process (GO:0046185)3.58112769
123organic acid catabolic process (GO:0016054)3.56423192
124carboxylic acid catabolic process (GO:0046395)3.56423192
125regulation of triglyceride catabolic process (GO:0010896)3.56127231
126regulation of triglyceride biosynthetic process (GO:0010866)3.54757244
127reverse cholesterol transport (GO:0043691)3.53189092
128adrenal gland development (GO:0030325)3.53168244
129phospholipid efflux (GO:0033700)3.47398136
130phagocytosis, recognition (GO:0006910)3.46056691
131organic cation transport (GO:0015695)3.44980180
132phospholipid homeostasis (GO:0055091)3.44844541
133response to monoamine (GO:0071867)3.43964395
134response to catecholamine (GO:0071869)3.43964395
135maternal behavior (GO:0042711)3.43238857
136plasma lipoprotein particle remodeling (GO:0034369)3.42892914
137protein-lipid complex remodeling (GO:0034368)3.42892914
138macromolecular complex remodeling (GO:0034367)3.42892914
139intracellular lipid transport (GO:0032365)3.42693153
140ethanol oxidation (GO:0006069)3.40687609
141acetyl-CoA metabolic process (GO:0006084)3.40412435
142flavonoid metabolic process (GO:0009812)3.38535011
143negative regulation of sterol transport (GO:0032372)3.37219043
144negative regulation of cholesterol transport (GO:0032375)3.37219043
145fatty acid oxidation (GO:0019395)3.35786991
146potassium ion export (GO:0071435)3.34625226
147fatty acid beta-oxidation (GO:0006635)3.33096592
148arginine metabolic process (GO:0006525)3.32984462
149pyrimidine nucleoside catabolic process (GO:0046135)3.32411557
150* steroid biosynthetic process (GO:0006694)3.29939272
151male genitalia development (GO:0030539)3.29829306
152lipid oxidation (GO:0034440)3.29635700
153positive regulation of triglyceride metabolic process (GO:0090208)3.29294257
154negative regulation of neurological system process (GO:0031645)3.28827645
155carnitine metabolic process (GO:0009437)3.28476788
156cytolysis (GO:0019835)3.28092787
157ovulation (GO:0030728)3.25856998
158myotube differentiation (GO:0014902)3.24392305
159amyloid precursor protein metabolic process (GO:0042982)3.23968829
160monocarboxylic acid catabolic process (GO:0072329)3.23888553
161sterol metabolic process (GO:0016125)3.23685366
162negative regulation of lipase activity (GO:0060192)3.23327391
163regulation of cholesterol esterification (GO:0010872)3.23210166
164regulation of steroid biosynthetic process (GO:0050810)3.21682173
165cofactor catabolic process (GO:0051187)3.20697595
166cellular ketone metabolic process (GO:0042180)3.20074996
167glycine metabolic process (GO:0006544)3.19372323
168cellular sodium ion homeostasis (GO:0006883)3.19046050
169cholesterol efflux (GO:0033344)3.18140219
170aspartate family amino acid catabolic process (GO:0009068)3.17591349
171serine family amino acid biosynthetic process (GO:0009070)3.17573534
172blood coagulation, intrinsic pathway (GO:0007597)3.17073119
173complement activation, classical pathway (GO:0006958)3.15434851
174valine metabolic process (GO:0006573)3.14733694
175positive regulation of systemic arterial blood pressure (GO:0003084)3.13889230
176regulation of female gonad development (GO:2000194)3.11733176
177positive regulation of steroid metabolic process (GO:0045940)3.11638719
178parental behavior (GO:0060746)3.11517895
179regulation of cholesterol biosynthetic process (GO:0045540)3.03258324
180positive regulation of digestive system process (GO:0060456)3.02882549
181positive regulation of fatty acid biosynthetic process (GO:0045723)3.02852387
182mating behavior (GO:0007617)3.02765454
183* glucocorticoid biosynthetic process (GO:0006704)20.2639381
184cellular response to dexamethasone stimulus (GO:0071549)2.98643076
185positive regulation of lipid biosynthetic process (GO:0046889)2.91987821
186detection of external biotic stimulus (GO:0098581)2.89156873
187regulation of cardioblast differentiation (GO:0051890)2.88988163
188regulation of hormone biosynthetic process (GO:0046885)2.84613310
189* cellular hormone metabolic process (GO:0034754)2.81345337
190* glucocorticoid metabolic process (GO:0008211)14.6837797
191C21-steroid hormone biosynthetic process (GO:0006700)13.4685553
192cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.5339791
193* androgen biosynthetic process (GO:0006702)10.3879606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.05403054
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.46384764
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.35346575
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.58551998
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.39412607
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.30603162
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.50629655
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.07387322
9CLOCK_20551151_ChIP-Seq_293T_Human3.04344380
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.80119860
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63165868
12GBX2_23144817_ChIP-Seq_PC3_Human2.60321083
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.58242298
14EZH2_22144423_ChIP-Seq_EOC_Human2.48809274
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36726745
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.32792602
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20765822
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97051797
19SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91584820
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89158076
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88078777
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.87163008
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.84616916
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82808914
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79794777
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75751221
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.72607563
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71557408
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.71377289
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.70466764
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69447319
32AR_21572438_ChIP-Seq_LNCaP_Human1.69243716
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.68106755
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.68106755
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.67360868
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61462108
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.59408813
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55629860
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55619468
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55146768
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.53289799
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51829712
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50448076
44VDR_24787735_ChIP-Seq_THP-1_Human1.48682878
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.47666678
46EGR1_19032775_ChIP-ChIP_M12_Human1.47269041
47HTT_18923047_ChIP-ChIP_STHdh_Human1.46395682
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46389282
49TAF15_26573619_Chip-Seq_HEK293_Human1.45622913
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44366800
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.42302111
52GF1_26923725_Chip-Seq_HPCs_Mouse1.42170453
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40193644
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40148989
55DROSHA_22980978_ChIP-Seq_HELA_Human1.39231699
56GATA1_19941826_ChIP-Seq_K562_Human1.36554754
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35723912
58P53_22387025_ChIP-Seq_ESCs_Mouse1.34042195
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33048921
60PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.32173651
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31133105
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30109702
63SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.29340398
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.28480256
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28390936
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27898980
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27490467
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27367293
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27237486
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.27018108
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.25942343
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24877553
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.24856485
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24110884
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.23787005
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.23144278
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23053553
78ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22980851
79PU1_27457419_Chip-Seq_LIVER_Mouse1.20801509
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18767455
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.18712773
82P300_18555785_Chip-Seq_ESCs_Mouse1.18473643
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18299418
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18057900
85SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16777366
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.15752103
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15751376
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14798796
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13796982
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13638926
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13507782
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.13332176
93ZFX_18555785_Chip-Seq_ESCs_Mouse1.12943975
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11802995
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10945781
96P300_19829295_ChIP-Seq_ESCs_Human1.10748425
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10609484
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.10520331
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10474191
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09183504
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08953311
102HNF4A_19822575_ChIP-Seq_HepG2_Human1.08784330
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.07873845
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07829331
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06791255
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06505210
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06425844
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06133697
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.06087106
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05838601
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05792316
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05169288
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04783717
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.04162686
115EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04050128
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04050128
117GATA2_19941826_ChIP-Seq_K562_Human1.02447656
118SMAD4_21799915_ChIP-Seq_A2780_Human1.02379114
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01954876
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.01281848
121STAT1_17558387_ChIP-Seq_HELA_Human1.00819055
122LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00633203
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.99995771
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99789600
125KDM2B_26808549_Chip-Seq_REH_Human0.98891865
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97472262
127KDM2B_26808549_Chip-Seq_K562_Human0.96420074
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96119988
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95870561
130IGF1R_20145208_ChIP-Seq_DFB_Human0.95416153
131GATA4_25053715_ChIP-Seq_YYC3_Human0.94527011
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94465239
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94367068
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93684728
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92629244
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91770207
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91533068
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91204246
139SOX2_20726797_ChIP-Seq_SW620_Human0.90441480
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89686057
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89397434
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88839393
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87524303
144LXR_22292898_ChIP-Seq_THP-1_Human0.87283487
145ESR2_21235772_ChIP-Seq_MCF-7_Human0.86824533
146STAT3_23295773_ChIP-Seq_U87_Human0.86413370
147BCAT_22108803_ChIP-Seq_LS180_Human0.86382280
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86255659
149SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85667897
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84286554
151TP53_18474530_ChIP-ChIP_U2OS_Human0.84169824
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83771711
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83446939
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82175915
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82089514
156EED_16625203_ChIP-ChIP_MESCs_Mouse0.79898137
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79686324
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79686324
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78810813
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78190392
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77898993
162CDX2_22108803_ChIP-Seq_LS180_Human0.77112482
163CBX2_27304074_Chip-Seq_ESCs_Mouse0.76007230
164GATA1_22025678_ChIP-Seq_K562_Human0.75199461
165AR_25329375_ChIP-Seq_VCAP_Human0.75117324
166ARNT_22903824_ChIP-Seq_MCF-7_Human0.74969803
167TCF4_23295773_ChIP-Seq_U87_Human0.74947387
168AHR_22903824_ChIP-Seq_MCF-7_Human0.74470948
169CDX2_20551321_ChIP-Seq_CACO-2_Human0.73931672
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72981850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.82285378
2MP0002139_abnormal_hepatobiliary_system7.70813133
3MP0005085_abnormal_gallbladder_physiolo5.86760196
4MP0005365_abnormal_bile_salt5.60182004
5MP0002909_abnormal_adrenal_gland5.37311625
6MP0008995_early_reproductive_senescence4.54706755
7MP0008875_abnormal_xenobiotic_pharmacok4.50374559
8MP0003252_abnormal_bile_duct4.16048702
9MP0003195_calcinosis3.75165191
10MP0004019_abnormal_vitamin_homeostasis3.35620938
11MP0002138_abnormal_hepatobiliary_system3.10942375
12MP0005332_abnormal_amino_acid2.99240249
13MP0003806_abnormal_nucleotide_metabolis2.74962790
14MP0010329_abnormal_lipoprotein_level2.74303915
15MP0003300_gastrointestinal_ulcer2.52646908
16MP0002837_dystrophic_cardiac_calcinosis2.47775825
17MP0001666_abnormal_nutrient_absorption2.23773899
18MP0005083_abnormal_biliary_tract2.21743954
19MP0005451_abnormal_body_composition2.16713471
20MP0001485_abnormal_pinna_reflex2.07221932
21MP0008004_abnormal_stomach_pH10.0732301
22MP0001984_abnormal_olfaction1.93314811
23MP0003868_abnormal_feces_composition1.84202217
24MP0003279_aneurysm1.73280747
25MP0002118_abnormal_lipid_homeostasis1.72781805
26MP0009643_abnormal_urine_homeostasis1.71394267
27MP0009697_abnormal_copulation1.67731309
28MP0001764_abnormal_homeostasis1.66960449
29MP0000609_abnormal_liver_physiology1.66130103
30MP0003191_abnormal_cellular_cholesterol1.65678506
31MP0006276_abnormal_autonomic_nervous1.63056253
32MP0004043_abnormal_pH_regulation1.61396021
33MP0008438_abnormal_cutaneous_collagen1.60869633
34MP0002876_abnormal_thyroid_physiology1.56906206
35MP0002896_abnormal_bone_mineralization1.56162224
36MP0002998_abnormal_bone_remodeling1.55146985
37MP0005319_abnormal_enzyme/_coenzyme1.51226485
38MP0003786_premature_aging1.49715256
39MP0003329_amyloid_beta_deposits1.48491459
40MP0004883_abnormal_blood_vessel1.46567862
41MP0005636_abnormal_mineral_homeostasis1.45186876
42MP0009764_decreased_sensitivity_to1.43845646
43MP0003283_abnormal_digestive_organ1.43368717
44MP0005595_abnormal_vascular_smooth1.40828363
45MP0005647_abnormal_sex_gland1.38909578
46MP0009840_abnormal_foam_cell1.34549725
47MP0005670_abnormal_white_adipose1.33545016
48MP0004134_abnormal_chest_morphology1.30935539
49MP0005584_abnormal_enzyme/coenzyme_acti1.30506879
50MP0002928_abnormal_bile_duct1.30036654
51MP0000631_abnormal_neuroendocrine_gland1.29148544
52MP0004381_abnormal_hair_follicle1.25861510
53MP0002127_abnormal_cardiovascular_syste1.25427762
54MP0005379_endocrine/exocrine_gland_phen1.25414216
55MP0003011_delayed_dark_adaptation1.24550602
56MP0000604_amyloidosis1.24338232
57MP0000462_abnormal_digestive_system1.20321310
58MP0005084_abnormal_gallbladder_morpholo1.19958733
59MP0000465_gastrointestinal_hemorrhage1.12231208
60MP0004272_abnormal_basement_membrane1.11497549
61MP0004233_abnormal_muscle_weight1.10513164
62MP0001765_abnormal_ion_homeostasis1.06915934
63MP0005508_abnormal_skeleton_morphology1.02705158
64MP0003186_abnormal_redox_activity1.02053927
65MP0000579_abnormal_nail_morphology1.01913409
66MP0002136_abnormal_kidney_physiology1.01780797
67MP0003828_pulmonary_edema0.97575570
68MP0001756_abnormal_urination0.96727078
69MP0003879_abnormal_hair_cell0.94955050
70MP0005076_abnormal_cell_differentiation0.93398488
71MP0004858_abnormal_nervous_system0.93117785
72MP0002877_abnormal_melanocyte_morpholog0.92617627
73MP0001119_abnormal_female_reproductive0.91851693
74MP0000569_abnormal_digit_pigmentation0.91179114
75MP0003724_increased_susceptibility_to0.90876941
76MP0002269_muscular_atrophy0.90714781
77MP0005220_abnormal_exocrine_pancreas0.90204361
78MP0000566_synostosis0.88676551
79MP0009763_increased_sensitivity_to0.87411121
80MP0008469_abnormal_protein_level0.87254936
81MP0009642_abnormal_blood_homeostasis0.85444769
82MP0005535_abnormal_body_temperature0.83436547
83MP0000538_abnormal_urinary_bladder0.82900413
84MP0001188_hyperpigmentation0.79797566
85MP0000013_abnormal_adipose_tissue0.79606588
86MP0001661_extended_life_span0.79266052
87MP0005164_abnormal_response_to0.79097132
88MP0005275_abnormal_skin_tensile0.78808102
89MP0004782_abnormal_surfactant_physiolog0.78755386
90MP0000598_abnormal_liver_morphology0.77932844
91MP0002254_reproductive_system_inflammat0.77757404
92MP0002557_abnormal_social/conspecific_i0.77727884
93MP0004484_altered_response_of0.76943447
94MP0002168_other_aberrant_phenotype0.74608143
95MP0001533_abnormal_skeleton_physiology0.73092161
96MP0004085_abnormal_heartbeat0.72562086
97MP0009765_abnormal_xenobiotic_induced0.72318843
98MP0005408_hypopigmentation0.71961168
99MP0000470_abnormal_stomach_morphology0.71951081
100MP0002132_abnormal_respiratory_system0.71573989
101MP0010368_abnormal_lymphatic_system0.70758955
102MP0000249_abnormal_blood_vessel0.69657650
103MP0001873_stomach_inflammation0.69160232
104MP0002078_abnormal_glucose_homeostasis0.68181120
105MP0005334_abnormal_fat_pad0.67758014
106MP0003699_abnormal_female_reproductive0.66907628
107MP0005330_cardiomyopathy0.66437779
108MP0000343_altered_response_to0.63542461
109MP0003091_abnormal_cell_migration0.61761598
110MP0005395_other_phenotype0.61451925
111MP0000383_abnormal_hair_follicle0.59453860
112MP0000427_abnormal_hair_cycle0.59343353
113MP0003705_abnormal_hypodermis_morpholog0.59220467
114MP0002971_abnormal_brown_adipose0.58989347
115MP0002115_abnormal_skeleton_extremities0.56791254
116MP0005646_abnormal_pituitary_gland0.56670542
117MP0005166_decreased_susceptibility_to0.55987531
118MP0004147_increased_porphyrin_level0.55852693
119MP0003137_abnormal_impulse_conducting0.55817919
120MP0001851_eye_inflammation0.55793965
121MP0005390_skeleton_phenotype0.55721674
122MP0005075_abnormal_melanosome_morpholog0.55261019
123MP0001881_abnormal_mammary_gland0.54051001
124MP0008260_abnormal_autophagy0.52303112
125MP0003953_abnormal_hormone_level0.52202435
126MP0000371_diluted_coat_color0.51956080
127MP0002332_abnormal_exercise_endurance0.51865506
128MP0002160_abnormal_reproductive_system0.51488972
129MP0002933_joint_inflammation0.51400752
130MP0003566_abnormal_cell_adhesion0.51220270
131MP0010352_gastrointestinal_tract_polyps0.48661708
132MP0005376_homeostasis/metabolism_phenot0.47971223
133MP0005389_reproductive_system_phenotype0.47857613
134MP0000230_abnormal_systemic_arterial0.47340954
135MP0009250_abnormal_appendicular_skeleto0.46750120
136MP0005023_abnormal_wound_healing0.46646226
137MP0009780_abnormal_chondrocyte_physiolo0.44853216
138MP0002098_abnormal_vibrissa_morphology0.43341925
139MP0000627_abnormal_mammary_gland0.43013979
140MP0001790_abnormal_immune_system0.42429404
141MP0005387_immune_system_phenotype0.42429404
142MP0003385_abnormal_body_wall0.41627312
143MP0001324_abnormal_eye_pigmentation0.41178158
144MP0003122_maternal_imprinting0.40810025
145MP0006292_abnormal_olfactory_placode0.40167904
146MP0005448_abnormal_energy_balance0.39658690
147MP0005464_abnormal_platelet_physiology0.39051962
148MP0006036_abnormal_mitochondrial_physio0.37775334
149MP0005377_hearing/vestibular/ear_phenot0.37717201
150MP0003878_abnormal_ear_physiology0.37717201
151MP0002102_abnormal_ear_morphology0.37532141
152MP0002277_abnormal_respiratory_mucosa0.36736102
153MP0002135_abnormal_kidney_morphology0.34669550
154MP0009384_cardiac_valve_regurgitation0.34342418
155MP0003656_abnormal_erythrocyte_physiolo0.34179828
156MP0005551_abnormal_eye_electrophysiolog0.34127148
157MP0001845_abnormal_inflammatory_respons0.33440960
158MP0006082_CNS_inflammation0.33088415
159MP0008874_decreased_physiological_sensi0.32029740
160MP0003638_abnormal_response/metabolism_0.31408332
161MP0003436_decreased_susceptibility_to0.30743906
162MP0001177_atelectasis0.30743747
163MP0003690_abnormal_glial_cell0.30133376
164MP0005058_abnormal_lysosome_morphology0.29909146
165MP0000639_abnormal_adrenal_gland0.29146629
166MP0002060_abnormal_skin_morphology0.28686345
167MP0001944_abnormal_pancreas_morphology0.28396393
168MP0000678_abnormal_parathyroid_gland0.27954319
169MP0010678_abnormal_skin_adnexa0.27845434

Predicted human phenotypes

RankGene SetZ-score
1Enlarged penis (HP:0000040)8.73578928
2Renal salt wasting (HP:0000127)8.08410682
3Hyperaldosteronism (HP:0000859)7.64278201
4Hypoplasia of the uterus (HP:0000013)7.14131973
5Intrahepatic cholestasis (HP:0001406)6.18228143
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.89772842
7Prolonged partial thromboplastin time (HP:0003645)5.41844362
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.08443732
9Anomalous pulmonary venous return (HP:0010772)5.04030643
10Abnormality of renin-angiotensin system (HP:0000847)5.00176836
11Aplasia/hypoplasia of the uterus (HP:0008684)4.98678802
12Deep venous thrombosis (HP:0002625)4.82924985
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.71949245
14Large earlobe (HP:0009748)4.67556757
15Joint hemorrhage (HP:0005261)4.65614183
16Xanthomatosis (HP:0000991)4.55108158
17Complement deficiency (HP:0004431)4.48869792
18Abnormality of the pulmonary veins (HP:0011718)4.39402563
19Relative macrocephaly (HP:0004482)4.27003452
20Conjugated hyperbilirubinemia (HP:0002908)4.20617154
21Hyperglycinuria (HP:0003108)4.18960587
22Abnormality of pyrimidine metabolism (HP:0004353)4.04143572
23Adrenal overactivity (HP:0002717)4.03861162
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88075797
25Ketosis (HP:0001946)3.86888216
26Hyperglycinemia (HP:0002154)3.83621450
27Abnormality of glycine metabolism (HP:0010895)3.78074448
28Abnormality of serine family amino acid metabolism (HP:0010894)3.78074448
29Hypobetalipoproteinemia (HP:0003563)3.77119387
30Sex reversal (HP:0012245)3.76480484
31Abnormal sex determination (HP:0012244)3.76480484
32Congenital sensorineural hearing impairment (HP:0008527)3.76223460
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.69947668
34Abnormality of nucleobase metabolism (HP:0010932)3.68125824
35Gout (HP:0001997)3.63307956
36Hyperlipoproteinemia (HP:0010980)3.59561612
37Epidermoid cyst (HP:0200040)3.59422838
38Hypokalemia (HP:0002900)3.56312174
39Hyperammonemia (HP:0001987)3.52275374
40Neonatal onset (HP:0003623)3.51527984
41Abnormality of purine metabolism (HP:0004352)3.50116951
42Fat malabsorption (HP:0002630)3.49696386
43Proximal tubulopathy (HP:0000114)3.46758836
44Gonadal dysgenesis (HP:0000133)3.34231430
45Abnormality of carpal bone ossification (HP:0006257)3.27652879
46Vascular calcification (HP:0004934)3.26570882
47Accelerated skeletal maturation (HP:0005616)3.23428381
48Ventricular fibrillation (HP:0001663)3.21313156
49Abnormality of the common coagulation pathway (HP:0010990)3.20566368
50Abnormality of methionine metabolism (HP:0010901)3.20290740
51Partial agenesis of the corpus callosum (HP:0001338)3.17653030
52Ureteral duplication (HP:0000073)3.17348204
53Generalized aminoaciduria (HP:0002909)3.15705087
54Abnormality of complement system (HP:0005339)3.14891347
55Abnormality of secondary sexual hair (HP:0009888)3.12004016
56Abnormality of the axillary hair (HP:0100134)3.12004016
57Ketoacidosis (HP:0001993)3.10535392
58Testicular neoplasm (HP:0010788)3.09393055
59Hypoglycemic coma (HP:0001325)3.08752519
60Abnormality of the aortic arch (HP:0012303)3.04887860
61Abnormality of the intrinsic pathway (HP:0010989)3.04495919
62Abnormality of fatty-acid metabolism (HP:0004359)3.00616870
63Enlarged kidneys (HP:0000105)2.99347305
64Clitoromegaly (HP:0000057)2.98929112
65Alkalosis (HP:0001948)2.98415906
66Hypolipoproteinemia (HP:0010981)2.98103612
67Delayed CNS myelination (HP:0002188)2.97053198
68Metaphyseal dysplasia (HP:0100255)2.95273834
69Hyperactive renin-angiotensin system (HP:0000841)2.94631116
70Renal cortical cysts (HP:0000803)2.92784606
71Abnormal pancreas size (HP:0012094)2.92591683
72Cardiovascular calcification (HP:0011915)2.88425920
73Hypoalphalipoproteinemia (HP:0003233)2.86258556
74Mesangial abnormality (HP:0001966)2.84572333
75Gynecomastia (HP:0000771)2.81533713
76Abnormality of serum amino acid levels (HP:0003112)2.79388643
77Hypophosphatemic rickets (HP:0004912)2.77552618
78Double outlet right ventricle (HP:0001719)2.75691150
79Congenital malformation of the right heart (HP:0011723)2.75691150
80Bilateral sensorineural hearing impairment (HP:0008619)2.75307652
81Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.75063721
82Wrist flexion contracture (HP:0001239)2.72236291
83Metabolic acidosis (HP:0001942)2.70358709
84Rickets (HP:0002748)2.69982005
85Increased purine levels (HP:0004368)2.69103596
86Hyperuricemia (HP:0002149)2.69103596
87Recurrent gram-negative bacterial infections (HP:0005420)2.64942232
88Hydroxyprolinuria (HP:0003080)2.62898029
89Abnormality of proline metabolism (HP:0010907)2.62898029
90Prolonged QT interval (HP:0001657)2.62379365
91Abnormal ossification of hand bones (HP:0005921)2.61612719
92Patent foramen ovale (HP:0001655)2.60511283
93Steatorrhea (HP:0002570)2.59736669
94Myocardial infarction (HP:0001658)2.59683853
95Systemic lupus erythematosus (HP:0002725)2.58615498
96Precocious puberty (HP:0000826)2.56998507
97Hypochromic microcytic anemia (HP:0004840)2.56671704
98Hyperbilirubinemia (HP:0002904)2.55016224
99Metabolic alkalosis (HP:0200114)2.54393308
100Dicarboxylic aciduria (HP:0003215)2.54190961
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54190961
102Cervical subluxation (HP:0003308)2.54173216
103Abnormal hand bone ossification (HP:0010660)2.53625000
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53523390
105Hypercholesterolemia (HP:0003124)2.50346681
106Glycosuria (HP:0003076)2.49829392
107Abnormality of urine glucose concentration (HP:0011016)2.49829392
108Increased circulating renin level (HP:0000848)2.47635009
109Persistence of primary teeth (HP:0006335)2.47570736
110Hepatocellular carcinoma (HP:0001402)2.46366779
111Abnormality of potassium homeostasis (HP:0011042)2.45162549
112Hypoglycemic seizures (HP:0002173)2.44454946
113Syncope (HP:0001279)2.44264203
114Abnormal enzyme/coenzyme activity (HP:0012379)2.43771932
115Alveolar cell carcinoma (HP:0006519)2.43316886
116Abnormality of chloride homeostasis (HP:0011422)2.39038140
117Premature ovarian failure (HP:0008209)2.38302062
118Azoospermia (HP:0000027)2.38211053
119Fair hair (HP:0002286)2.37667173
120Hypoplastic nipples (HP:0002557)2.34603743
121Nephritis (HP:0000123)2.32431788
122Hypophosphatemia (HP:0002148)2.31393583
123Cupped ear (HP:0000378)2.28252948
124Elevated alkaline phosphatase (HP:0003155)2.28223522
125Abnormality of the alveolar ridges (HP:0006477)2.27912135
126Short humerus (HP:0005792)2.27716061
127Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26178321
128Abnormality of alkaline phosphatase activity (HP:0004379)2.25841598
129Hypokalemic alkalosis (HP:0001949)2.25426100
130Polyuria (HP:0000103)2.25304250
131Hypomagnesemia (HP:0002917)2.25202369
132Abnormal urine output (HP:0012590)2.25101854
133Abnormality of the clitoris (HP:0000056)2.24478982
134Rhizomelia (HP:0008905)2.24412874
135Symptomatic seizures (HP:0011145)2.24078742
136Mitral stenosis (HP:0001718)2.23071293
137Cerebral palsy (HP:0100021)2.20053228
138* Male pseudohermaphroditism (HP:0000037)2.19564210
139Pancreatitis (HP:0001733)2.19132520
140Abnormality of the fetal cardiovascular system (HP:0010948)2.18649665
141Abnormal umbilical cord blood vessels (HP:0011403)2.18649665
142Single umbilical artery (HP:0001195)2.18649665
143Sensorimotor neuropathy (HP:0007141)2.17375948
144Short clavicles (HP:0000894)2.17231999
145Abnormality of the renal cortex (HP:0011035)2.17157880
146Abnormality of renal excretion (HP:0011036)2.16691501
147Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15463709
148Neoplasm of the tracheobronchial system (HP:0100552)2.15024938
149Tetany (HP:0001281)2.13935438
150Lethargy (HP:0001254)2.12975636
151Secondary amenorrhea (HP:0000869)2.12222161
152Confusion (HP:0001289)2.05975860
153Osteomalacia (HP:0002749)2.04659684
154Syringomyelia (HP:0003396)2.03263081
155Spinal cord lesions (HP:0100561)2.03263081
156Hyperventilation (HP:0002883)2.02124233
157Menorrhagia (HP:0000132)2.01788040
158Nephrolithiasis (HP:0000787)2.00831063
159Decreased circulating renin level (HP:0003351)10.4285378
160Aplasia of the musculature (HP:0100854)1.99413316
161Aplasia/hypoplasia of the humerus (HP:0006507)1.99131406
162Renal tubular acidosis (HP:0001947)1.98201872
163Aplasia/Hypoplasia of the clavicles (HP:0006710)1.97423545
164Opisthotonus (HP:0002179)1.97249812
165Glomerulonephritis (HP:0000099)1.97135960
166Vertebral clefting (HP:0008428)1.96987312
167Decreased testicular size (HP:0008734)1.96439200
168Gingival bleeding (HP:0000225)1.96295147
169Abnormal biliary tract physiology (HP:0012439)1.95667655
170Hyperpituitarism (HP:0010514)1.94567388
171Limited hip movement (HP:0008800)1.85813076
172Sparse lateral eyebrow (HP:0005338)1.78542382
173Ulnar bowing (HP:0003031)1.74859604
174Spinal cord compression (HP:0002176)1.74583176
175Cupped ribs (HP:0000887)1.74073339
176Abnormal tarsal ossification (HP:0008369)1.72508166
177Diastasis recti (HP:0001540)1.71998136
178Neurofibrillary tangles (HP:0002185)1.71763112
179Lymphangioma (HP:0100764)1.71552431
180Absent epiphyses (HP:0010577)1.69179731
181Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69179731
182Gonadotropin excess (HP:0000837)1.65019836
183Abnormal spermatogenesis (HP:0008669)1.60014347
184Primary amenorrhea (HP:0000786)1.59363156
185Growth hormone excess (HP:0000845)1.56728477
186Vertebral arch anomaly (HP:0008438)1.56489489
187Protrusio acetabuli (HP:0003179)1.54882381
188Absent hand (HP:0004050)1.54551621
189Breast hypoplasia (HP:0003187)1.54195480
190J-shaped sella turcica (HP:0002680)1.51724441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.29965693
2INSRR4.04504988
3MELK3.34901110
4BCKDK3.30629448
5WNK32.87450120
6ICK2.73614986
7FGFR42.62073536
8WNK42.60912638
9MAP3K52.60677771
10CASK2.60463060
11TAOK32.52424509
12MAP3K142.48719578
13IRAK32.35617889
14STK38L2.31208155
15SIK12.26431313
16ERBB42.16430680
17EIF2AK22.06364946
18FRK2.06154318
19OXSR12.03165431
20PDK22.02456334
21GRK12.00370974
22SGK21.95022901
23PIK3CG1.75631649
24ZAK1.71591126
25LATS11.66970302
26SGK2231.52237588
27SGK4941.52237588
28RIPK11.44062000
29ERN11.42397743
30SGK31.41447621
31AKT31.40025822
32TXK1.37126072
33JAK11.33942211
34PDK11.30184863
35MAPK151.28174628
36MST1R1.27002976
37MAPK111.25407267
38PIM11.23768947
39PDPK11.23626870
40IRAK41.22379385
41PRKAA21.20832588
42EPHA31.11913642
43IRAK11.05227081
44ADRBK21.04712268
45PINK11.03051663
46PKN11.01466103
47NUAK11.01412714
48PDGFRA1.00459397
49MAP3K71.00085468
50TYK20.98775662
51MAPK70.96895559
52CDK70.95382434
53EPHB10.93748717
54SIK30.93066451
55AKT20.93017751
56NTRK10.88562818
57PRPF4B0.88340909
58MAP2K40.87325946
59DAPK20.86892612
60IKBKE0.86380142
61YES10.85500824
62TRIB30.82202640
63TNIK0.81357431
64BMPR20.80952067
65MAP2K70.80081356
66MTOR0.79223697
67PRKAA10.78748095
68FGFR20.75267950
69CAMK1D0.73962473
70TAOK20.72995796
71STK160.69935141
72CDC42BPA0.69719130
73TGFBR20.69300211
74TIE10.68744364
75SIK20.68011568
76IRAK20.67556172
77SGK10.67544741
78ERBB20.67282496
79TEC0.67131365
80STK100.66639260
81STK380.66428041
82MAPK30.65567027
83CAMK1G0.65134457
84RPS6KA50.62545284
85MAP2K20.61696825
86LMTK20.60873162
87LRRK20.58328853
88NEK60.58321816
89JAK20.57602705
90CHUK0.57500104
91MAPK120.57175008
92PRKCZ0.55714449
93NEK90.54936723
94CDK30.54577545
95GSK3A0.53718065
96MAP3K130.53230117
97IKBKB0.53121987
98PTK60.52979657
99FER0.52625502
100PKN20.52409478
101FLT30.52242988
102MAPKAPK50.51634235
103BMPR1B0.51535593
104EPHA40.50962862
105NLK0.50717942
106PRKCQ0.49089447
107MAP3K30.48924677
108BRD40.48416217
109KIT0.48246246
110PIK3CA0.47907130
111STK390.47725400
112MYLK0.47566709
113FGFR30.47375476
114CAMK40.46612100
115CSK0.46523145
116PRKACG0.46062667
117TTN0.45872262
118TNK20.45250841
119GRK70.44711831
120PTK20.44133641
121MAP3K60.44050309
122WNK10.43532397
123PDGFRB0.42992668
124TBK10.41220686
125PRKCG0.41006063
126PRKCE0.40472731
127ROCK20.40346088
128RET0.39376728
129IGF1R0.38688232
130MAPK10.37238455
131EPHB20.36630508
132CAMK2G0.34980746
133ROCK10.34884623
134PRKACA0.34652313
135MAP2K60.33695442
136ACVR1B0.33251815
137STK30.32600415
138DMPK0.32551735
139PRKCA0.32523633
140DYRK20.31248933
141EEF2K0.31173093
142RPS6KC10.30988586
143RPS6KL10.30988586
144PRKD20.30738147
145KSR20.30015913
146CSF1R0.28978568
147KDR0.25585182
148PRKG20.25362711
149MAP3K20.24594460
150CAMKK20.24300878
151PHKG20.22386272
152PHKG10.22386272
153MAPK40.22301339
154RPS6KA60.21712388
155MARK20.19173785
156RPS6KA30.17693900
157PRKD30.17206931
158RPS6KA20.16378699
159HIPK20.15952319
160CAMK2B0.15919618

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ovarian steroidogenesis_Homo sapiens_hsa049135.17849548
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.18983915
3* Aldosterone synthesis and secretion_Homo sapiens_hsa049253.84316516
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45708086
5Tryptophan metabolism_Homo sapiens_hsa003803.03291103
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71521371
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64690689
8Butanoate metabolism_Homo sapiens_hsa006502.57927641
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54858353
10Complement and coagulation cascades_Homo sapiens_hsa046102.47998698
11Fatty acid degradation_Homo sapiens_hsa000712.44660629
12Arginine biosynthesis_Homo sapiens_hsa002202.44067951
13Peroxisome_Homo sapiens_hsa041462.39898867
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.37409845
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30368809
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27567226
17Propanoate metabolism_Homo sapiens_hsa006402.17583742
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14260907
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13718895
20beta-Alanine metabolism_Homo sapiens_hsa004102.12553057
21Histidine metabolism_Homo sapiens_hsa003402.10329072
22Nitrogen metabolism_Homo sapiens_hsa009102.08724409
23* Steroid hormone biosynthesis_Homo sapiens_hsa001402.03349616
24Retinol metabolism_Homo sapiens_hsa008301.95721359
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91223074
26Chemical carcinogenesis_Homo sapiens_hsa052041.76962073
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76214024
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76074521
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72047219
30Fatty acid metabolism_Homo sapiens_hsa012121.69108896
31PPAR signaling pathway_Homo sapiens_hsa033201.67271041
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.65538148
33Selenocompound metabolism_Homo sapiens_hsa004501.62740132
34Phenylalanine metabolism_Homo sapiens_hsa003601.62122226
35Staphylococcus aureus infection_Homo sapiens_hsa051501.61606334
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.61440573
37ABC transporters_Homo sapiens_hsa020101.60557049
38Vitamin digestion and absorption_Homo sapiens_hsa049771.51139103
39Starch and sucrose metabolism_Homo sapiens_hsa005001.49429047
40Bile secretion_Homo sapiens_hsa049761.47446335
41Caffeine metabolism_Homo sapiens_hsa002321.47323574
42Sulfur metabolism_Homo sapiens_hsa009201.46437818
43Tyrosine metabolism_Homo sapiens_hsa003501.41745541
44Prolactin signaling pathway_Homo sapiens_hsa049171.35404063
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32897835
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28846646
47Lysine degradation_Homo sapiens_hsa003101.25753729
48Pyruvate metabolism_Homo sapiens_hsa006201.23981411
49Fatty acid elongation_Homo sapiens_hsa000621.20988108
50Steroid biosynthesis_Homo sapiens_hsa001001.18313416
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.18151985
52ECM-receptor interaction_Homo sapiens_hsa045121.12022370
53Arginine and proline metabolism_Homo sapiens_hsa003301.09314201
54Folate biosynthesis_Homo sapiens_hsa007901.07479819
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06332876
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06252086
57Vitamin B6 metabolism_Homo sapiens_hsa007501.01092200
58Pertussis_Homo sapiens_hsa051331.01045206
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94845730
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92750749
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.82476488
62One carbon pool by folate_Homo sapiens_hsa006700.82046977
63Focal adhesion_Homo sapiens_hsa045100.77225434
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.74372498
65Fat digestion and absorption_Homo sapiens_hsa049750.72793357
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.71436500
67Carbon metabolism_Homo sapiens_hsa012000.69386885
68Glycerolipid metabolism_Homo sapiens_hsa005610.68690154
69Gastric acid secretion_Homo sapiens_hsa049710.68266165
70Glutathione metabolism_Homo sapiens_hsa004800.66109426
71Vibrio cholerae infection_Homo sapiens_hsa051100.65668784
72Choline metabolism in cancer_Homo sapiens_hsa052310.62298362
73Pancreatic secretion_Homo sapiens_hsa049720.59111400
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57949017
75Biosynthesis of amino acids_Homo sapiens_hsa012300.54694661
76Amoebiasis_Homo sapiens_hsa051460.52336982
77Gap junction_Homo sapiens_hsa045400.51973758
78Sulfur relay system_Homo sapiens_hsa041220.51246811
79* Metabolic pathways_Homo sapiens_hsa011000.49720220
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49481556
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46895611
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.46070291
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43994652
84Systemic lupus erythematosus_Homo sapiens_hsa053220.43467252
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37549205
86TNF signaling pathway_Homo sapiens_hsa046680.37027532
87mTOR signaling pathway_Homo sapiens_hsa041500.37020556
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34262480
89Circadian rhythm_Homo sapiens_hsa047100.33487438
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31512289
91GnRH signaling pathway_Homo sapiens_hsa049120.31227208
92Linoleic acid metabolism_Homo sapiens_hsa005910.31161186
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31108684
94Small cell lung cancer_Homo sapiens_hsa052220.29547414
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.29132883
96Proteoglycans in cancer_Homo sapiens_hsa052050.27249206
97Calcium signaling pathway_Homo sapiens_hsa040200.27154649
98TGF-beta signaling pathway_Homo sapiens_hsa043500.26932921
99Arachidonic acid metabolism_Homo sapiens_hsa005900.26453387
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.26256026
101Insulin signaling pathway_Homo sapiens_hsa049100.25706178
102Dorso-ventral axis formation_Homo sapiens_hsa043200.25125658
103Toxoplasmosis_Homo sapiens_hsa051450.25017888
104Estrogen signaling pathway_Homo sapiens_hsa049150.23219412
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23192659
106Fatty acid biosynthesis_Homo sapiens_hsa000610.22908611
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22857968
108Other glycan degradation_Homo sapiens_hsa005110.22536088
109Long-term depression_Homo sapiens_hsa047300.22336800
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21153841
111Dilated cardiomyopathy_Homo sapiens_hsa054140.21025367
112Pentose phosphate pathway_Homo sapiens_hsa000300.20125152
113AMPK signaling pathway_Homo sapiens_hsa041520.18671406
114Cholinergic synapse_Homo sapiens_hsa047250.17207209
115Insulin resistance_Homo sapiens_hsa049310.17176365
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16319291
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16074871
118Mineral absorption_Homo sapiens_hsa049780.15810807
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15324345
120Apoptosis_Homo sapiens_hsa042100.15226744
121ErbB signaling pathway_Homo sapiens_hsa040120.15223055
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15188084
123Adherens junction_Homo sapiens_hsa045200.14382080
124Prion diseases_Homo sapiens_hsa050200.14179132
125Serotonergic synapse_Homo sapiens_hsa047260.13850353
126Protein digestion and absorption_Homo sapiens_hsa049740.13249674
127Galactose metabolism_Homo sapiens_hsa000520.11694094
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.11314330
129Fructose and mannose metabolism_Homo sapiens_hsa000510.11214301
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11115898
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08184221
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.07547016
133Regulation of autophagy_Homo sapiens_hsa041400.07269777
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.07063108
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06024209
136Glucagon signaling pathway_Homo sapiens_hsa049220.04633969
137Collecting duct acid secretion_Homo sapiens_hsa049660.03129556
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.01523020
139Hepatitis C_Homo sapiens_hsa051600.01225937
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00590509
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.00401117
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00314868
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.00105879
144Ether lipid metabolism_Homo sapiens_hsa00565-0.0706768
145Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0509835
146Renin-angiotensin system_Homo sapiens_hsa04614-0.0339209
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0244803
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0126472
149Sphingolipid metabolism_Homo sapiens_hsa00600-0.0086052

Most similar genes based on co-expression Upload to Enrichr

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