HSD17B14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.56694898
2nucleobase biosynthetic process (GO:0046112)5.38164511
3mitotic metaphase plate congression (GO:0007080)5.15113566
4oligosaccharide catabolic process (GO:0009313)5.13408624
5ribosome biogenesis (GO:0042254)5.08677274
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.92201220
7L-phenylalanine catabolic process (GO:0006559)4.92201220
8DNA replication checkpoint (GO:0000076)4.73697817
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66407101
10L-phenylalanine metabolic process (GO:0006558)4.66407101
11formation of translation preinitiation complex (GO:0001731)4.58896725
12ribosome assembly (GO:0042255)4.57509401
13amino sugar catabolic process (GO:0046348)4.40328546
14protein localization to kinetochore (GO:0034501)4.39254843
15rRNA modification (GO:0000154)4.38663375
16DNA replication initiation (GO:0006270)4.35353445
17regulation of nuclear cell cycle DNA replication (GO:0033262)4.24272999
18regulation of cholesterol esterification (GO:0010872)4.03263456
19metaphase plate congression (GO:0051310)4.03090777
20regulation of gene silencing by RNA (GO:0060966)4.02422526
21regulation of posttranscriptional gene silencing (GO:0060147)4.02422526
22regulation of gene silencing by miRNA (GO:0060964)4.02422526
23regulation of spindle organization (GO:0090224)3.99870449
24ribonucleoprotein complex biogenesis (GO:0022613)3.97916517
25glycosphingolipid catabolic process (GO:0046479)3.93507730
26folic acid metabolic process (GO:0046655)3.92044954
27mitotic nuclear envelope disassembly (GO:0007077)3.89599315
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88102588
29mitotic sister chromatid segregation (GO:0000070)3.87085780
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86461735
31transcription from mitochondrial promoter (GO:0006390)3.84250647
32DNA strand elongation involved in DNA replication (GO:0006271)3.78946740
33nuclear pore organization (GO:0006999)3.77967289
34DNA deamination (GO:0045006)3.77076392
35positive regulation of chromosome segregation (GO:0051984)3.76405071
36regulation of mononuclear cell migration (GO:0071675)3.72815697
37DNA replication-dependent nucleosome organization (GO:0034723)3.70473973
38DNA replication-dependent nucleosome assembly (GO:0006335)3.70473973
39phospholipid efflux (GO:0033700)3.69658006
40transcription from RNA polymerase I promoter (GO:0006360)3.68087626
41IMP biosynthetic process (GO:0006188)3.66763821
42aromatic amino acid family catabolic process (GO:0009074)3.65949009
43termination of RNA polymerase III transcription (GO:0006386)3.65930503
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.65930503
45protein K6-linked ubiquitination (GO:0085020)3.63542120
46DNA strand elongation (GO:0022616)3.63247993
47telomere maintenance via semi-conservative replication (GO:0032201)3.61700486
48regulation of double-strand break repair via homologous recombination (GO:0010569)3.61092019
49rRNA methylation (GO:0031167)3.59604982
50protein localization to chromosome, centromeric region (GO:0071459)3.58608233
51maturation of SSU-rRNA (GO:0030490)3.58580786
52rRNA processing (GO:0006364)3.58512440
53nuclear envelope disassembly (GO:0051081)3.57937427
54membrane disassembly (GO:0030397)3.57937427
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.57722748
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57722748
57vitamin D metabolic process (GO:0042359)3.57384156
58vitamin transmembrane transport (GO:0035461)3.56589188
59L-alpha-amino acid transmembrane transport (GO:1902475)3.54415151
60regulation of mitotic spindle organization (GO:0060236)3.53552694
61cholesterol efflux (GO:0033344)3.51287673
62glycolipid catabolic process (GO:0019377)3.50978415
63regulation of translation in response to stress (GO:0043555)3.49360681
64rRNA metabolic process (GO:0016072)3.47181977
65phenylpropanoid metabolic process (GO:0009698)3.46386686
66kinetochore assembly (GO:0051382)3.45426918
67spliceosomal snRNP assembly (GO:0000387)3.45248227
68maturation of 5.8S rRNA (GO:0000460)3.43473012
69sphingolipid catabolic process (GO:0030149)3.41433435
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.41086489
71pseudouridine synthesis (GO:0001522)3.40318508
72reverse cholesterol transport (GO:0043691)3.39539246
73glucosamine-containing compound catabolic process (GO:1901072)3.37903379
74termination of RNA polymerase I transcription (GO:0006363)3.34253742
75membrane lipid catabolic process (GO:0046466)3.32226376
76regulation of type B pancreatic cell apoptotic process (GO:2000674)3.30614669
77histone H4-K12 acetylation (GO:0043983)3.30517749
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.28722634
79high-density lipoprotein particle remodeling (GO:0034375)3.28191546
80replication fork processing (GO:0031297)3.27442794
81establishment of chromosome localization (GO:0051303)3.26172952
82ceramide catabolic process (GO:0046514)3.26022045
83negative regulation of chromosome segregation (GO:0051985)3.25659640
84glyoxylate metabolic process (GO:0046487)3.25195397
85nuclear pore complex assembly (GO:0051292)3.24267750
86intestinal epithelial cell development (GO:0060576)3.22160623
87xenobiotic catabolic process (GO:0042178)3.21677865
88regulation of cytokine secretion involved in immune response (GO:0002739)3.21445773
89vasodilation (GO:0042311)3.20665656
90glycerophospholipid catabolic process (GO:0046475)3.20445203
91transcription initiation from RNA polymerase I promoter (GO:0006361)3.20117123
92regulation of telomere maintenance via telomerase (GO:0032210)3.19172516
93cellular ketone body metabolic process (GO:0046950)3.19038533
94protein carboxylation (GO:0018214)3.18797469
95peptidyl-glutamic acid carboxylation (GO:0017187)3.18797469
96adhesion of symbiont to host cell (GO:0044650)3.18535776
97virion attachment to host cell (GO:0019062)3.18535776
987-methylguanosine mRNA capping (GO:0006370)3.18482638
99telomere maintenance via recombination (GO:0000722)3.18417190
100spindle checkpoint (GO:0031577)3.17849432
101transcription-coupled nucleotide-excision repair (GO:0006283)3.16397961
102regulation of chromosome segregation (GO:0051983)3.14137783
103CENP-A containing nucleosome assembly (GO:0034080)3.13340894
104ATP hydrolysis coupled proton transport (GO:0015991)3.12892110
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.12892110
106sister chromatid segregation (GO:0000819)3.12768349
107kinetochore organization (GO:0051383)3.12630248
108regulation of helicase activity (GO:0051095)3.12007497
109positive regulation of calcium ion import (GO:0090280)3.11636454
110chromatin remodeling at centromere (GO:0031055)3.11402673
111histone arginine methylation (GO:0034969)3.11002920
112transferrin transport (GO:0033572)3.10883377
113mitotic spindle checkpoint (GO:0071174)3.10248614
114regulation of fibrinolysis (GO:0051917)3.09184614
115telomere maintenance via telomere lengthening (GO:0010833)3.08756740
1167-methylguanosine RNA capping (GO:0009452)3.08062519
117RNA capping (GO:0036260)3.08062519
118attachment of spindle microtubules to kinetochore (GO:0008608)3.08015021
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06186278
120negative regulation of sister chromatid segregation (GO:0033046)3.05749026
121negative regulation of mitotic sister chromatid separation (GO:2000816)3.05749026
122negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05749026
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05749026
124establishment of protein localization to mitochondrial membrane (GO:0090151)3.02974749
125mitotic recombination (GO:0006312)3.02141539
126DNA replication-independent nucleosome organization (GO:0034724)3.01236792
127DNA replication-independent nucleosome assembly (GO:0006336)3.01236792
128proteasome assembly (GO:0043248)3.00462571
129spindle assembly checkpoint (GO:0071173)2.99832999
130folic acid-containing compound biosynthetic process (GO:0009396)2.99577246
131keratan sulfate catabolic process (GO:0042340)2.99266786
132mitotic spindle assembly checkpoint (GO:0007094)2.99042214
133regulation of centrosome cycle (GO:0046605)2.98936283
134water-soluble vitamin biosynthetic process (GO:0042364)2.97165065
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96212030
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95646681
137plasma lipoprotein particle clearance (GO:0034381)2.95061691
138IMP metabolic process (GO:0046040)2.93531404
139trivalent inorganic cation transport (GO:0072512)2.92729280
140ferric iron transport (GO:0015682)2.92729280
141ribosomal large subunit biogenesis (GO:0042273)2.92655170
142nuclear envelope organization (GO:0006998)2.92284340
143N-acetylneuraminate metabolic process (GO:0006054)2.92177273
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90455074
145glycine metabolic process (GO:0006544)2.89541877
146ketone body metabolic process (GO:1902224)2.87773841
147vitamin biosynthetic process (GO:0009110)2.87413480
148neuromuscular process controlling posture (GO:0050884)2.83096692
149adhesion of symbiont to host (GO:0044406)2.82562374
150lytic vacuole organization (GO:0080171)2.82190004
151lysosome organization (GO:0007040)2.82190004
152phagosome maturation (GO:0090382)2.78901657
153energy homeostasis (GO:0097009)2.78568429
154fat-soluble vitamin biosynthetic process (GO:0042362)2.77661896
155positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.77396730
156L-ascorbic acid metabolic process (GO:0019852)2.77152181
157triglyceride homeostasis (GO:0070328)2.76793576
158acylglycerol homeostasis (GO:0055090)2.76793576
159protein-lipid complex remodeling (GO:0034368)2.76362502
160macromolecular complex remodeling (GO:0034367)2.76362502
161plasma lipoprotein particle remodeling (GO:0034369)2.76362502
162negative regulation of cholesterol transport (GO:0032375)2.75547560
163negative regulation of sterol transport (GO:0032372)2.75547560
164heme transport (GO:0015886)2.73565613
165bile acid biosynthetic process (GO:0006699)2.73421088
166nitric oxide biosynthetic process (GO:0006809)2.69666448
167positive regulation of neurotransmitter transport (GO:0051590)2.69512150
168amine catabolic process (GO:0009310)2.68473076
169cellular biogenic amine catabolic process (GO:0042402)2.68473076
170endosome to melanosome transport (GO:0035646)2.65349126
171endosome to pigment granule transport (GO:0043485)2.65349126
172positive regulation of neurotransmitter secretion (GO:0001956)2.62389244
173triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.61524648
174serine family amino acid catabolic process (GO:0009071)2.60194905
175positive regulation of heat generation (GO:0031652)2.58377530
176response to acidic pH (GO:0010447)2.56734611
177epoxygenase P450 pathway (GO:0019373)2.55589514
178regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54643824
179macroautophagy (GO:0016236)2.53973275
180tryptophan catabolic process (GO:0006569)2.53724821
181indole-containing compound catabolic process (GO:0042436)2.53724821
182indolalkylamine catabolic process (GO:0046218)2.53724821
183glycosphingolipid metabolic process (GO:0006687)2.53614949
184positive regulation of insulin secretion (GO:0032024)2.53356278
185peptide hormone processing (GO:0016486)2.52625529
186positive regulation of steroid metabolic process (GO:0045940)2.51789774
187fibrinolysis (GO:0042730)2.48784651
188positive regulation of sterol transport (GO:0032373)2.48391943
189positive regulation of cholesterol transport (GO:0032376)2.48391943
190positive regulation of triglyceride lipase activity (GO:0061365)2.47104109
191positive regulation of lipoprotein lipase activity (GO:0051006)2.47104109
192branching involved in labyrinthine layer morphogenesis (GO:0060670)2.44766438
193alanine transport (GO:0032328)2.43891133
194platelet dense granule organization (GO:0060155)2.42472210
195iron coordination entity transport (GO:1901678)2.42470092
196positive regulation of TOR signaling (GO:0032008)2.41894717
197iron ion transport (GO:0006826)2.39565830
198eosinophil chemotaxis (GO:0048245)2.39026003
199regulation of fever generation (GO:0031620)2.38873116
200response to dietary excess (GO:0002021)2.38062729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.53555238
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.97533521
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67030354
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.46610177
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24638110
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21094581
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.03646537
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.03646537
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.03646537
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.98507368
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95246554
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81113352
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79962437
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.78555945
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76486540
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75634981
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75582597
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70664800
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.69168708
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.69044620
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61166129
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.60672069
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59559661
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.53277649
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.51047351
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48202500
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43502203
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41916705
29LXR_22158963_ChIP-Seq_LIVER_Mouse2.35376574
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29609369
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.25974287
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24344807
33PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24079686
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22620299
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20300453
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.14609152
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11319528
38EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11251275
39IRF8_21731497_ChIP-ChIP_J774_Mouse2.10461080
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05068767
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04987940
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01590214
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.99475447
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99117077
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94545944
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94072662
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.93881494
48XRN2_22483619_ChIP-Seq_HELA_Human1.93374257
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.90354591
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84126352
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80074032
52SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78786253
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78468656
54AR_21909140_ChIP-Seq_LNCAP_Human1.77676515
55VDR_23849224_ChIP-Seq_CD4+_Human1.77611366
56NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74802747
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.74671410
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73409407
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68188283
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.66762884
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66132854
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64552396
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.64418361
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63550392
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61286630
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59382485
67GABP_19822575_ChIP-Seq_HepG2_Human1.58347772
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57224078
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56477853
70DCP1A_22483619_ChIP-Seq_HELA_Human1.55210047
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52781606
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.51032545
73FOXP3_21729870_ChIP-Seq_TREG_Human1.50652604
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50445492
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50360717
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47406849
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.44194423
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.42822943
79TTF2_22483619_ChIP-Seq_HELA_Human1.42617384
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.40393490
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39670655
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39376652
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37765473
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37454287
85SOX2_20726797_ChIP-Seq_SW620_Human1.36797139
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35787095
87NANOG_18692474_ChIP-Seq_MEFs_Mouse1.34337172
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32422771
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31319568
90KDM5A_27292631_Chip-Seq_BREAST_Human1.30481428
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30164479
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29867854
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.28688436
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28502201
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27745209
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27186897
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25686098
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25142847
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24892367
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24516593
101HTT_18923047_ChIP-ChIP_STHdh_Human1.23564372
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21010296
103NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19564200
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19486553
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18857160
106POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17333898
107KAP1_27257070_Chip-Seq_ESCs_Mouse1.16820155
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13114411
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12770989
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11389906
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10937012
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09573191
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.09077793
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08707171
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.07566092
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06512863
117EGR1_19374776_ChIP-ChIP_THP-1_Human1.06381100
118ELK1_19687146_ChIP-ChIP_HELA_Human1.05225252
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04351142
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04189835
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03657099
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03381301
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02189637
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.00763889
125STAT1_20625510_ChIP-Seq_HELA_Human0.98108307
126LXR_22292898_ChIP-Seq_THP-1_Human0.97149878
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96446710
128CIITA_25753668_ChIP-Seq_RAJI_Human0.96387734
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96380977
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95852999
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95238950
132ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94525369
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93751548
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93421245
135REST_21632747_ChIP-Seq_MESCs_Mouse0.93288746
136MYC_22102868_ChIP-Seq_BL_Human0.92393755
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91039039
138ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90240924
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.89351648
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89296317
141BCAT_22108803_ChIP-Seq_LS180_Human0.89171456
142LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89152542
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89084480
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88579937
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87661269
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86181295
147TFEB_21752829_ChIP-Seq_HELA_Human0.86173971
148GBX2_23144817_ChIP-Seq_PC3_Human0.85986443
149MYC_19829295_ChIP-Seq_ESCs_Human0.85027434
150NANOG_16518401_ChIP-PET_MESCs_Mouse0.84895805
151CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84631032
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84628105
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84577843
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84308234
155VDR_24787735_ChIP-Seq_THP-1_Human0.83644238
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83460450
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83306563
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82824041
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82195667
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81477079
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81036937
162NANOG_19829295_ChIP-Seq_ESCs_Human0.80351696
163SOX2_19829295_ChIP-Seq_ESCs_Human0.80351696
164SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80184109
165NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79303467
166NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79303467
167NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78154850
168SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76762604
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76483899
170SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.76451189
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76446399
172SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.76059488
173AR_20517297_ChIP-Seq_VCAP_Human0.75523414
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.74679625
175PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73910126
176SMAD3_21741376_ChIP-Seq_EPCs_Human0.73889580
177* MITF_21258399_ChIP-Seq_MELANOMA_Human0.73760941
178HNF4A_19822575_ChIP-Seq_HepG2_Human0.73230895
179CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72973908
180GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72638951
181FOXA2_19822575_ChIP-Seq_HepG2_Human0.72472238
182MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72174321
183NANOG_18555785_Chip-Seq_ESCs_Mouse0.71209290
184AR_25329375_ChIP-Seq_VCAP_Human0.70798638
185SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69919250
186TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69451036
187TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.69275326
188SMAD4_21741376_ChIP-Seq_EPCs_Human0.69023161
189EED_16625203_ChIP-ChIP_MESCs_Mouse0.68835009
190EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.68341032
191CBP_21632823_ChIP-Seq_H3396_Human0.68271298
192TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67935443
193BP1_19119308_ChIP-ChIP_Hs578T_Human0.67351897
194TRIM28_21343339_ChIP-Seq_HEK293_Human0.67254146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.47098231
2MP0002139_abnormal_hepatobiliary_system5.38506025
3MP0005058_abnormal_lysosome_morphology5.02583284
4MP0008057_abnormal_DNA_replication4.66079553
5MP0003111_abnormal_nucleus_morphology4.51419180
6MP0004957_abnormal_blastocyst_morpholog4.46598857
7MP0010094_abnormal_chromosome_stability4.22064439
8MP0009840_abnormal_foam_cell4.15496395
9MP0002254_reproductive_system_inflammat3.97162847
10MP0003195_calcinosis3.94984433
11MP0003077_abnormal_cell_cycle3.61009607
12MP0003172_abnormal_lysosome_physiology3.55355213
13MP0003718_maternal_effect3.32083578
14MP0008058_abnormal_DNA_repair3.21026316
15MP0006082_CNS_inflammation2.87449543
16MP0002837_dystrophic_cardiac_calcinosis2.85013209
17MP0005365_abnormal_bile_salt2.66661758
18MP0003786_premature_aging2.50857219
19MP0003123_paternal_imprinting2.49107417
20MP0008932_abnormal_embryonic_tissue2.47890782
21MP0001730_embryonic_growth_arrest2.35425972
22MP0005360_urolithiasis2.32022139
23MP0003806_abnormal_nucleotide_metabolis2.31285102
24MP0002653_abnormal_ependyma_morphology2.27923672
25MP0000350_abnormal_cell_proliferation2.26341360
26MP0008007_abnormal_cellular_replicative2.25967772
27MP0000604_amyloidosis2.19839266
28MP0006054_spinal_hemorrhage2.09938952
29MP0005380_embryogenesis_phenotype2.08093344
30MP0001672_abnormal_embryogenesis/_devel2.08093344
31MP0002909_abnormal_adrenal_gland2.06941644
32MP0002090_abnormal_vision2.03062941
33MP0006292_abnormal_olfactory_placode2.01427003
34MP0003011_delayed_dark_adaptation2.01154142
35MP0002138_abnormal_hepatobiliary_system1.97231173
36MP0004133_heterotaxia1.95116699
37MP0003941_abnormal_skin_development1.93091434
38MP0005167_abnormal_blood-brain_barrier1.89150860
39MP0004510_myositis1.87029449
40MP0003690_abnormal_glial_cell1.86996107
41MP0003303_peritoneal_inflammation1.85540183
42MP0010329_abnormal_lipoprotein_level1.79564989
43MP0005332_abnormal_amino_acid1.77676721
44MP0010352_gastrointestinal_tract_polyps1.77367256
45MP0005379_endocrine/exocrine_gland_phen1.74628639
46MP0002085_abnormal_embryonic_tissue1.73726720
47MP0003984_embryonic_growth_retardation1.73020355
48MP0001697_abnormal_embryo_size1.72494362
49MP0003890_abnormal_embryonic-extraembry1.69932797
50MP0010386_abnormal_urinary_bladder1.69645074
51MP0003122_maternal_imprinting1.69041318
52MP0002088_abnormal_embryonic_growth/wei1.69015293
53MP0006072_abnormal_retinal_apoptosis1.68778866
54MP0010234_abnormal_vibrissa_follicle1.65727814
55MP0003878_abnormal_ear_physiology1.65013092
56MP0005377_hearing/vestibular/ear_phenot1.65013092
57MP0003136_yellow_coat_color1.63904855
58MP0010307_abnormal_tumor_latency1.63535939
59MP0003075_altered_response_to1.62626766
60MP0002084_abnormal_developmental_patter1.59361180
61MP0002086_abnormal_extraembryonic_tissu1.57255944
62MP0002080_prenatal_lethality1.55961668
63MP0001293_anophthalmia1.53274578
64MP0002876_abnormal_thyroid_physiology1.52874745
65MP0010030_abnormal_orbit_morphology1.48482783
66MP0003879_abnormal_hair_cell1.45793869
67MP0004264_abnormal_extraembryonic_tissu1.42162280
68MP0003119_abnormal_digestive_system1.40976401
69MP0003329_amyloid_beta_deposits1.35585459
70MP0000343_altered_response_to1.35227869
71MP0004197_abnormal_fetal_growth/weight/1.35031924
72MP0005085_abnormal_gallbladder_physiolo1.33868541
73MP0008877_abnormal_DNA_methylation1.33004293
74MP0002210_abnormal_sex_determination1.31999496
75MP0001756_abnormal_urination1.30988836
76MP0003633_abnormal_nervous_system1.30209061
77MP0009046_muscle_twitch1.29985559
78MP0003315_abnormal_perineum_morphology1.28783298
79MP0008875_abnormal_xenobiotic_pharmacok1.28580062
80MP0000313_abnormal_cell_death1.26678900
81MP0003283_abnormal_digestive_organ1.26401284
82MP0002118_abnormal_lipid_homeostasis1.25219227
83MP0001944_abnormal_pancreas_morphology1.25212693
84MP0001145_abnormal_male_reproductive1.24897192
85MP0002693_abnormal_pancreas_physiology1.22832866
86MP0003634_abnormal_glial_cell1.21015410
87MP0001764_abnormal_homeostasis1.17994636
88MP0000490_abnormal_crypts_of1.16468358
89MP0003567_abnormal_fetal_cardiomyocyte1.15450729
90MP0002148_abnormal_hypersensitivity_rea1.14631507
91MP0001984_abnormal_olfaction1.13781130
92MP0005395_other_phenotype1.12285677
93MP0008260_abnormal_autophagy1.09349567
94MP0005646_abnormal_pituitary_gland1.08497304
95MP0002295_abnormal_pulmonary_circulatio1.07487784
96MP0001501_abnormal_sleep_pattern1.07433177
97MP0003186_abnormal_redox_activity1.07204263
98MP0001849_ear_inflammation1.07055248
99MP0002396_abnormal_hematopoietic_system1.04431625
100MP0005253_abnormal_eye_physiology1.03893555
101MP0002019_abnormal_tumor_incidence1.02924391
102MP0000920_abnormal_myelination1.01713684
103MP0002064_seizures1.01555834
104MP0005257_abnormal_intraocular_pressure1.01125822
105MP0000750_abnormal_muscle_regeneration1.01032316
106MP0005076_abnormal_cell_differentiation1.00859482
107MP0009643_abnormal_urine_homeostasis1.00776117
108MP0000653_abnormal_sex_gland0.99408463
109MP0003121_genomic_imprinting0.98356343
110MP0003938_abnormal_ear_development0.97705212
111MP0001929_abnormal_gametogenesis0.97410046
112MP0002078_abnormal_glucose_homeostasis0.97256537
113MP0005266_abnormal_metabolism0.96239892
114MP0009333_abnormal_splenocyte_physiolog0.95466907
115MP0005367_renal/urinary_system_phenotyp0.95194961
116MP0000516_abnormal_urinary_system0.95194961
117MP0005535_abnormal_body_temperature0.93933380
118MP0002229_neurodegeneration0.93894521
119MP0004043_abnormal_pH_regulation0.93847320
120MP0003300_gastrointestinal_ulcer0.92414903
121MP0001545_abnormal_hematopoietic_system0.92098117
122MP0005397_hematopoietic_system_phenotyp0.92098117
123MP0006035_abnormal_mitochondrial_morpho0.92094937
124MP0003868_abnormal_feces_composition0.92042054
125MP0003191_abnormal_cellular_cholesterol0.91656682
126MP0008469_abnormal_protein_level0.91465516
127MP0004270_analgesia0.91009561
128MP0005636_abnormal_mineral_homeostasis0.90923284
129MP0005551_abnormal_eye_electrophysiolog0.90704865
130MP0002277_abnormal_respiratory_mucosa0.89950430
131MP0001324_abnormal_eye_pigmentation0.89628278
132MP0002132_abnormal_respiratory_system0.89513049
133MP0005248_abnormal_Harderian_gland0.87472070
134MP0003936_abnormal_reproductive_system0.86455581
135MP0002111_abnormal_tail_morphology0.85473934
136MP0001661_extended_life_span0.84308084
137MP0005448_abnormal_energy_balance0.83902593
138MP0002160_abnormal_reproductive_system0.83152907
139MP0005075_abnormal_melanosome_morpholog0.83114743
140MP0009764_decreased_sensitivity_to0.82884174
141MP0000358_abnormal_cell_content/0.82854957
142MP0003631_nervous_system_phenotype0.82687505
143MP0005408_hypopigmentation0.82289953
144MP0000609_abnormal_liver_physiology0.80830763
145MP0009785_altered_susceptibility_to0.80230106
146MP0002092_abnormal_eye_morphology0.79988925
147MP0005384_cellular_phenotype0.79071069
148MP0001286_abnormal_eye_development0.78793283
149MP0002638_abnormal_pupillary_reflex0.78668226
150MP0005389_reproductive_system_phenotype0.78644810
151MP0000538_abnormal_urinary_bladder0.78214458
152MP0000639_abnormal_adrenal_gland0.76753131
153MP0002127_abnormal_cardiovascular_syste0.76512373
154MP0002269_muscular_atrophy0.76215597
155MP0001119_abnormal_female_reproductive0.76032538
156MP0005394_taste/olfaction_phenotype0.75882084
157MP0005499_abnormal_olfactory_system0.75882084
158MP0005621_abnormal_cell_physiology0.75653505
159MP0002796_impaired_skin_barrier0.75036063
160MP0009278_abnormal_bone_marrow0.74603196
161MP0005501_abnormal_skin_physiology0.74430349
162MP0005319_abnormal_enzyme/_coenzyme0.73903470
163MP0005584_abnormal_enzyme/coenzyme_acti0.72606084
164MP0003937_abnormal_limbs/digits/tail_de0.72162051
165MP0005310_abnormal_salivary_gland0.72060098
166MP0000372_irregular_coat_pigmentation0.71110177
167MP0009703_decreased_birth_body0.70957631
168MP0000371_diluted_coat_color0.70055412
169MP0008789_abnormal_olfactory_epithelium0.69997466
170MP0003221_abnormal_cardiomyocyte_apopto0.69498174
171MP0001905_abnormal_dopamine_level0.67914166
172MP0000432_abnormal_head_morphology0.67704805
173MP0003632_abnormal_nervous_system0.67457453
174MP0002938_white_spotting0.67211305
175MP0005647_abnormal_sex_gland0.66856166
176MP0003699_abnormal_female_reproductive0.65613241
177MP0003755_abnormal_palate_morphology0.65513330
178MP0002419_abnormal_innate_immunity0.65476023
179MP0001845_abnormal_inflammatory_respons0.65203097
180MP0009745_abnormal_behavioral_response0.64726686
181MP0000627_abnormal_mammary_gland0.64331340
182MP0001666_abnormal_nutrient_absorption0.63957035
183MP0002557_abnormal_social/conspecific_i0.63279614
184MP0002332_abnormal_exercise_endurance0.62781324
185MP0005645_abnormal_hypothalamus_physiol0.61496874
186MP0002998_abnormal_bone_remodeling0.61437073
187MP0001542_abnormal_bone_strength0.60636422
188MP0002161_abnormal_fertility/fecundity0.60584066
189MP0004019_abnormal_vitamin_homeostasis0.60413353

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.51317273
2Abnormality of liposaccharide metabolism (HP:0010968)7.51317273
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.51317273
4Vacuolated lymphocytes (HP:0001922)5.85230897
5Birth length less than 3rd percentile (HP:0003561)5.21821093
6Breast hypoplasia (HP:0003187)5.18371590
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.04732811
8Nuclear cataract (HP:0100018)4.80541735
9Impulsivity (HP:0100710)4.56282388
10Systemic lupus erythematosus (HP:0002725)4.54340510
11Dysostosis multiplex (HP:0000943)4.48804566
12Carpal bone hypoplasia (HP:0001498)4.43592468
13Loss of speech (HP:0002371)4.29903587
14Increased cerebral lipofuscin (HP:0011813)4.16000280
15Abnormality of mucopolysaccharide metabolism (HP:0011020)4.13934420
16Abnormality of polysaccharide metabolism (HP:0011012)4.13934420
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.13934420
18Absent radius (HP:0003974)4.04177358
19Abnormality of the labia minora (HP:0012880)3.98817017
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94787984
21Retinal atrophy (HP:0001105)3.93397573
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.86272233
23Patellar aplasia (HP:0006443)3.83323612
24Mucopolysacchariduria (HP:0008155)3.83163112
25Urinary glycosaminoglycan excretion (HP:0003541)3.83163112
26Aplasia involving forearm bones (HP:0009822)3.82491134
27Absent forearm bone (HP:0003953)3.82491134
28Progressive neurologic deterioration (HP:0002344)3.82239621
29Mutism (HP:0002300)3.76899320
30Disinhibition (HP:0000734)3.67960134
31Cerebral hypomyelination (HP:0006808)3.64597306
32Aplasia/Hypoplasia of the patella (HP:0006498)3.62442531
33Ependymoma (HP:0002888)3.58136348
34Chromsome breakage (HP:0040012)3.57321755
35Rough bone trabeculation (HP:0100670)3.49799431
36Aplasia/hypoplasia of the humerus (HP:0006507)3.48778460
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.48597701
38Hyperglycinuria (HP:0003108)3.43108565
39Hyperglycinemia (HP:0002154)3.35529020
40Prolonged neonatal jaundice (HP:0006579)3.34055655
41Degeneration of anterior horn cells (HP:0002398)3.29462564
42Abnormality of the anterior horn cell (HP:0006802)3.29462564
43Selective tooth agenesis (HP:0001592)3.18535317
44Rectal fistula (HP:0100590)3.15287235
45Rectovaginal fistula (HP:0000143)3.15287235
46Supernumerary spleens (HP:0009799)3.13816076
47Short humerus (HP:0005792)3.11269092
48Increased CSF protein (HP:0002922)3.09142996
49Glomerulonephritis (HP:0000099)3.08027318
50Multiple enchondromatosis (HP:0005701)3.05426254
51Meckel diverticulum (HP:0002245)3.00463921
52Neurofibrillary tangles (HP:0002185)3.00334484
53Abnormality of the ileum (HP:0001549)3.00201924
54Premature ovarian failure (HP:0008209)2.95385775
55Absent thumb (HP:0009777)2.91804031
56Spinal muscular atrophy (HP:0007269)2.91496295
57Abnormality of the preputium (HP:0100587)2.83623436
58Rib fusion (HP:0000902)2.81612590
59Complement deficiency (HP:0004431)2.81372413
60Xanthomatosis (HP:0000991)2.80302726
61Congenital malformation of the right heart (HP:0011723)2.76610431
62Double outlet right ventricle (HP:0001719)2.76610431
63Axonal loss (HP:0003447)2.75332784
64Hematochezia (HP:0002573)2.75047471
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.73219251
66Vaginal fistula (HP:0004320)2.71049446
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.70738535
68Intestinal fistula (HP:0100819)2.70018567
69Hyperinsulinemic hypoglycemia (HP:0000825)2.69394676
70Oral leukoplakia (HP:0002745)2.62584386
71Hypoglycemic coma (HP:0001325)2.59705008
72Cardiomegaly (HP:0001640)2.59542280
73Shawl scrotum (HP:0000049)2.59205087
74Progressive muscle weakness (HP:0003323)2.58387700
75Trismus (HP:0000211)2.58343836
76Ureteral duplication (HP:0000073)2.57855360
77Polyphagia (HP:0002591)2.55128797
78Hypoglycemic seizures (HP:0002173)2.53246442
79Abnormal trabecular bone morphology (HP:0100671)2.53153844
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52427282
81Abnormality of serine family amino acid metabolism (HP:0010894)2.44325920
82Abnormality of glycine metabolism (HP:0010895)2.44325920
83Abnormality of chromosome stability (HP:0003220)2.42898656
84Hyperglycemia (HP:0003074)2.42820099
85Abnormality of the astrocytes (HP:0100707)2.42330590
86Astrocytoma (HP:0009592)2.42330590
87Prolonged partial thromboplastin time (HP:0003645)2.40134765
88Diminished motivation (HP:0000745)2.40130408
89Abnormality of macrophages (HP:0004311)2.38855166
90Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36999590
91Agitation (HP:0000713)2.34952353
92Ketoacidosis (HP:0001993)2.34617263
93Glioma (HP:0009733)2.34487484
94Horseshoe kidney (HP:0000085)2.34234203
95Intrahepatic cholestasis (HP:0001406)2.34204417
96Tongue fasciculations (HP:0001308)2.32252849
97Medulloblastoma (HP:0002885)2.30975645
98Sparse eyelashes (HP:0000653)2.30677704
99Small intestinal stenosis (HP:0012848)2.30158140
100Duodenal stenosis (HP:0100867)2.30158140
101Reticulocytopenia (HP:0001896)2.28856694
102Sensorimotor neuropathy (HP:0007141)2.28563294
103Fused cervical vertebrae (HP:0002949)2.26423800
104Atrophy/Degeneration involving motor neurons (HP:0007373)2.24382364
105Secondary amenorrhea (HP:0000869)2.22927792
106Gout (HP:0001997)2.21329433
107Areflexia of lower limbs (HP:0002522)2.20357006
108Rhabdomyosarcoma (HP:0002859)2.19983509
109Mesangial abnormality (HP:0001966)2.17954899
110Generalized aminoaciduria (HP:0002909)2.17866773
111Apathy (HP:0000741)2.17673744
112Tracheoesophageal fistula (HP:0002575)2.16945729
113Duplicated collecting system (HP:0000081)2.16285035
114Bone marrow hypocellularity (HP:0005528)2.15801262
115Muscle fibrillation (HP:0010546)2.15113460
116Metaphyseal irregularity (HP:0003025)2.14616169
117Hyperlipoproteinemia (HP:0010980)2.14192990
118Breast aplasia (HP:0100783)2.14163646
119Hypomagnesemia (HP:0002917)2.14085834
120Abnormal number of incisors (HP:0011064)2.13948482
121Ketosis (HP:0001946)2.11822097
122Premature graying of hair (HP:0002216)2.11357195
123Stenosis of the external auditory canal (HP:0000402)2.11046922
124Inappropriate behavior (HP:0000719)2.09941980
125Facial hemangioma (HP:0000329)2.09868740
126Microretrognathia (HP:0000308)2.09619348
127Zonular cataract (HP:0010920)2.09601521
128Abnormality of the lower motor neuron (HP:0002366)2.07962550
129J-shaped sella turcica (HP:0002680)2.07711714
130Abnormality of magnesium homeostasis (HP:0004921)2.07538999
131Purpura (HP:0000979)2.05592495
132Hypoplasia of the radius (HP:0002984)2.05202786
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04660550
134Large for gestational age (HP:0001520)2.03685525
135Symptomatic seizures (HP:0011145)2.03538910
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03344105
137Short thumb (HP:0009778)2.02724039
138Dementia (HP:0000726)2.02432729
139Methylmalonic aciduria (HP:0012120)2.01702614
140Pustule (HP:0200039)2.00476040
141Deep venous thrombosis (HP:0002625)1.98294586
142Increased circulating renin level (HP:0000848)1.97557853
143Irritability (HP:0000737)1.97156531
144Hypoalphalipoproteinemia (HP:0003233)1.95713043
145Neoplasm of the oral cavity (HP:0100649)1.95658557
146Abdominal situs inversus (HP:0003363)1.95443641
147Abnormality of abdominal situs (HP:0011620)1.95443641
148Abnormality of the duodenum (HP:0002246)1.95392750
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.95251661
150Beaking of vertebral bodies (HP:0004568)1.94359582
151Dysautonomia (HP:0002459)1.92941210
152CNS hypomyelination (HP:0003429)1.92683585
153Colon cancer (HP:0003003)1.92510636
154Sloping forehead (HP:0000340)1.91710536
155Abnormality of pyrimidine metabolism (HP:0004353)1.91569629
156Intestinal atresia (HP:0011100)1.91158072
157Triphalangeal thumb (HP:0001199)1.90231869
158Cleft eyelid (HP:0000625)1.90070763
159Myelodysplasia (HP:0002863)1.89008572
160Anal stenosis (HP:0002025)1.88650976
161Sparse lateral eyebrow (HP:0005338)1.88482563
162Ectopic kidney (HP:0000086)1.87852962
163Death in infancy (HP:0001522)1.87526640
164Abnormality of fatty-acid metabolism (HP:0004359)1.87351240
165Concave nail (HP:0001598)1.86863430
166Hypobetalipoproteinemia (HP:0003563)1.86632665
167Abnormality of the umbilical cord (HP:0010881)1.85839925
168Abnormal drinking behavior (HP:0030082)1.85512544
169Polydipsia (HP:0001959)1.85512544
170Adrenal hypoplasia (HP:0000835)1.84483034
171Facial cleft (HP:0002006)1.83849959
172Protuberant abdomen (HP:0001538)1.83020535
173Abnormality of complement system (HP:0005339)1.82375958
174Cerebral inclusion bodies (HP:0100314)1.82320937
175Neoplasm of striated muscle (HP:0009728)1.82172503
176Hypothermia (HP:0002045)1.82123798
177Myoclonus (HP:0001336)1.82096638
178Absent hand (HP:0004050)1.81527221
179Hypolipoproteinemia (HP:0010981)1.79653773
180Arthropathy (HP:0003040)1.78490563
181Postural tremor (HP:0002174)1.74565674
182Pathologic fracture (HP:0002756)1.71992368
183Albinism (HP:0001022)1.71132084
184Urinary incontinence (HP:0000020)1.70712971
185Hypokinesia (HP:0002375)1.69817594
186Episodic fever (HP:0001954)1.68581443
187Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68556254
188Petechiae (HP:0000967)1.66954302
189Late onset (HP:0003584)1.66875599
190Restlessness (HP:0000711)1.66645081
191Neuronal loss in central nervous system (HP:0002529)1.66499892
192Focal dystonia (HP:0004373)1.66277627
193Congenital sensorineural hearing impairment (HP:0008527)1.65871538
194Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65101753
195Abnormality of calcium-phosphate metabolism (HP:0100530)1.62581847
196Asymmetric septal hypertrophy (HP:0001670)1.59976804
197Progressive macrocephaly (HP:0004481)1.59961022
198Delayed CNS myelination (HP:0002188)1.59566265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.44888903
2WEE14.59716453
3FRK4.14108631
4AKT33.65851882
5PLK42.76794801
6CDK122.76194633
7EPHA22.73448776
8TTK2.68270347
9GRK72.63575184
10EIF2AK12.62643001
11NEK12.47610415
12TSSK62.44731800
13NEK22.41751767
14PLK12.41120900
15FGFR22.26844135
16MAP4K22.23866534
17TAOK12.23088623
18DAPK22.13716377
19CDC72.11576537
20SRPK12.11027299
21CDK72.10569073
22MAP2K62.04259173
23WNK41.96017743
24PINK11.91880035
25TESK11.88369215
26BRSK21.83861887
27ABL21.76818565
28NME21.76389361
29DYRK31.71579518
30CHEK21.71011634
31PLK31.70743886
32ACVR1B1.68220072
33MOS1.61736459
34EIF2AK31.60219286
35RPS6KB21.58832382
36MKNK21.57668194
37LIMK11.52930109
38FER1.51616069
39MAP3K31.45869559
40EPHA31.41152044
41STK161.38153001
42AURKB1.37863359
43PRKCG1.37658017
44PDK41.36068021
45PDK31.36068021
46PDK21.36049364
47MKNK11.35346444
48AURKA1.34970917
49TBK11.34887466
50PHKG11.32870021
51PHKG21.32870021
52ZAK1.30825820
53NTRK31.27348776
54TESK21.25238005
55ATR1.23246907
56STK38L1.22171836
57CAMK2D1.21955409
58LATS21.20373169
59TGFBR21.18715788
60BRSK11.18586113
61ALK1.17213250
62CHEK11.16719469
63TNIK1.14195004
64MAPKAPK31.12305429
65CSNK1G21.11551872
66CSNK1G11.11258658
67PRKCI1.07188623
68VRK11.07080306
69MAP3K141.05999616
70PLK21.05247331
71PRKG21.00531840
72NLK0.98581155
73MAP3K10.98209229
74PNCK0.96124133
75CDK40.95841682
76TIE10.94327120
77EIF2AK20.92800300
78MAP3K80.92303133
79CDK20.90044682
80MAP3K40.90022508
81DAPK30.89246856
82PIM20.87241611
83BMPR1B0.86672168
84PIM10.86055183
85TGFBR10.83708000
86IRAK10.83631564
87RIPK10.83479153
88CHUK0.83388761
89CDC42BPA0.83142652
90STK100.81609336
91PAK40.81432961
92PRKCE0.81254399
93EPHB10.80035723
94DYRK20.79307771
95FGFR30.78596629
96WNK30.78372130
97FGR0.77081581
98STK40.73654488
99OXSR10.72858392
100ICK0.72232952
101BRAF0.71996707
102BLK0.71947928
103STK30.70220824
104ATM0.68543971
105EPHB20.67506336
106STK390.67345293
107ERN10.66736651
108RPS6KA40.66715433
109BCKDK0.66261485
110DDR20.65576539
111CSNK2A20.65390580
112CSNK2A10.64424057
113PAK10.64193953
114MATK0.63232096
115TNK20.60827516
116CDK10.59487180
117TYK20.58773327
118CAMK2G0.58219921
119IRAK20.58017344
120IRAK30.57950888
121CCNB10.56727142
122MAP3K120.56560736
123CSNK1E0.56522045
124MAPK150.56352085
125HIPK20.55734468
126CSNK1A10.54772940
127CSNK1A1L0.54763298
128CASK0.54712423
129BMPR20.53447306
130GSK3A0.53361487
131BRD40.53199224
132MTOR0.51794087
133ARAF0.50989383
134TLK10.49771017
135YES10.49657575
136AKT20.48827674
137TYRO30.47390924
138GRK10.47361288
139GRK50.46091590
140GRK60.45490741
141TAOK20.44275514
142MELK0.44258948
143PAK60.44226146
144PASK0.43432269
145PRKAA20.42947589
146FGFR40.42571162
147INSRR0.42443903
148CDK60.41926000
149MAP2K70.38380598
150PRKG10.37581580
151IKBKE0.37014322
152PAK30.35694857
153ERBB30.35661238
154MST40.34368850
155PRKCA0.34336298
156ROCK20.34217589
157CAMK2A0.33319484
158PRKAA10.32721049
159SIK30.32116997
160MAP3K110.31634820
161PDPK10.31152109
162MET0.30878916
163CAMKK20.30180492
164MAP3K130.30146864
165NEK60.29157823
166MAP3K90.28086439
167MAPK140.24881210
168DAPK10.24592981
169RPS6KA50.24443753
170STK380.24030089
171GSK3B0.22362790
172ADRBK20.21704478
173CSNK1G30.21627156
174MAPK10.20669295
175LATS10.19222800
176IKBKB0.18214620

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.75575270
2Vitamin B6 metabolism_Homo sapiens_hsa007504.26712960
3Other glycan degradation_Homo sapiens_hsa005114.21265620
4RNA polymerase_Homo sapiens_hsa030204.15657932
5DNA replication_Homo sapiens_hsa030303.95407135
6Mismatch repair_Homo sapiens_hsa034303.67417665
7Lysosome_Homo sapiens_hsa041423.35295343
8RNA transport_Homo sapiens_hsa030133.34093842
9Glycosaminoglycan degradation_Homo sapiens_hsa005313.04555419
10Maturity onset diabetes of the young_Homo sapiens_hsa049503.00882249
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.99374718
12Spliceosome_Homo sapiens_hsa030402.90646910
13Proteasome_Homo sapiens_hsa030502.69616262
14Collecting duct acid secretion_Homo sapiens_hsa049662.65746041
15Base excision repair_Homo sapiens_hsa034102.62541262
16Homologous recombination_Homo sapiens_hsa034402.53909080
17Ribosome_Homo sapiens_hsa030102.50301402
18Nucleotide excision repair_Homo sapiens_hsa034202.50218528
19Cell cycle_Homo sapiens_hsa041102.47889768
20Pyrimidine metabolism_Homo sapiens_hsa002402.46259155
21One carbon pool by folate_Homo sapiens_hsa006702.34331775
22Complement and coagulation cascades_Homo sapiens_hsa046102.31626798
23Sulfur metabolism_Homo sapiens_hsa009202.22848424
24Fanconi anemia pathway_Homo sapiens_hsa034602.21421554
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11993818
26Basal transcription factors_Homo sapiens_hsa030222.03953034
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01191697
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99302730
29Folate biosynthesis_Homo sapiens_hsa007901.98396597
30Rheumatoid arthritis_Homo sapiens_hsa053231.87558171
31p53 signaling pathway_Homo sapiens_hsa041151.85903337
32Butanoate metabolism_Homo sapiens_hsa006501.81753253
33Tryptophan metabolism_Homo sapiens_hsa003801.74658685
34Vibrio cholerae infection_Homo sapiens_hsa051101.66675955
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62217316
36Oxidative phosphorylation_Homo sapiens_hsa001901.60759563
37Peroxisome_Homo sapiens_hsa041461.57288171
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57148233
39mRNA surveillance pathway_Homo sapiens_hsa030151.53253087
40Synaptic vesicle cycle_Homo sapiens_hsa047211.48359595
41Sphingolipid metabolism_Homo sapiens_hsa006001.47832767
42Biosynthesis of amino acids_Homo sapiens_hsa012301.47809785
43RNA degradation_Homo sapiens_hsa030181.45853916
44Purine metabolism_Homo sapiens_hsa002301.43823140
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41816063
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38315699
47Protein export_Homo sapiens_hsa030601.34051908
48Staphylococcus aureus infection_Homo sapiens_hsa051501.30798812
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.30244276
50Fatty acid elongation_Homo sapiens_hsa000621.29518464
51Non-homologous end-joining_Homo sapiens_hsa034501.26985452
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26102995
53Fatty acid degradation_Homo sapiens_hsa000711.25232434
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23670052
55Fructose and mannose metabolism_Homo sapiens_hsa000511.22897681
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15081197
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14785410
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.14599264
59Type I diabetes mellitus_Homo sapiens_hsa049401.12643660
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12107925
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11641296
62PPAR signaling pathway_Homo sapiens_hsa033201.11214409
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09968183
64Insulin secretion_Homo sapiens_hsa049111.09402208
65Chemical carcinogenesis_Homo sapiens_hsa052041.07750103
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06844406
67Arginine biosynthesis_Homo sapiens_hsa002201.04539859
68Pentose phosphate pathway_Homo sapiens_hsa000301.04258998
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03789304
70Regulation of autophagy_Homo sapiens_hsa041401.03172663
71Oocyte meiosis_Homo sapiens_hsa041141.02732826
72Prion diseases_Homo sapiens_hsa050201.02586141
73Retinol metabolism_Homo sapiens_hsa008301.02521763
74Epstein-Barr virus infection_Homo sapiens_hsa051691.02440283
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.96765914
76Pertussis_Homo sapiens_hsa051330.95684861
77Sulfur relay system_Homo sapiens_hsa041220.89609321
78Vitamin digestion and absorption_Homo sapiens_hsa049770.84415556
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.82431802
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79019985
81Phagosome_Homo sapiens_hsa041450.78489350
82Bile secretion_Homo sapiens_hsa049760.77724512
83Fatty acid metabolism_Homo sapiens_hsa012120.77344126
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77290017
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.77064280
86Selenocompound metabolism_Homo sapiens_hsa004500.75282130
87Phenylalanine metabolism_Homo sapiens_hsa003600.75224783
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74791719
89Glutathione metabolism_Homo sapiens_hsa004800.72898619
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71871050
91Histidine metabolism_Homo sapiens_hsa003400.67546380
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67526182
93Carbon metabolism_Homo sapiens_hsa012000.65038304
94Steroid biosynthesis_Homo sapiens_hsa001000.64948592
95Type II diabetes mellitus_Homo sapiens_hsa049300.64555906
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62916790
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62865871
98Arachidonic acid metabolism_Homo sapiens_hsa005900.62395791
99Arginine and proline metabolism_Homo sapiens_hsa003300.62061402
100Caffeine metabolism_Homo sapiens_hsa002320.60663690
101Propanoate metabolism_Homo sapiens_hsa006400.58517904
102Ether lipid metabolism_Homo sapiens_hsa005650.57739968
103Hippo signaling pathway_Homo sapiens_hsa043900.57095451
104Parkinsons disease_Homo sapiens_hsa050120.55577310
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54694439
106Linoleic acid metabolism_Homo sapiens_hsa005910.54595588
107Galactose metabolism_Homo sapiens_hsa000520.53661427
108Asthma_Homo sapiens_hsa053100.49451551
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48428838
110Herpes simplex infection_Homo sapiens_hsa051680.47942196
111Viral carcinogenesis_Homo sapiens_hsa052030.47352038
112Tyrosine metabolism_Homo sapiens_hsa003500.46651853
113Salmonella infection_Homo sapiens_hsa051320.45524865
114mTOR signaling pathway_Homo sapiens_hsa041500.45469045
115Metabolic pathways_Homo sapiens_hsa011000.42705801
116Tuberculosis_Homo sapiens_hsa051520.41973123
117ABC transporters_Homo sapiens_hsa020100.41803826
118Hedgehog signaling pathway_Homo sapiens_hsa043400.41639255
119Osteoclast differentiation_Homo sapiens_hsa043800.40577628
120Alzheimers disease_Homo sapiens_hsa050100.39899014
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38535174
122African trypanosomiasis_Homo sapiens_hsa051430.38122762
123Antigen processing and presentation_Homo sapiens_hsa046120.36455955
124Starch and sucrose metabolism_Homo sapiens_hsa005000.36091626
125Malaria_Homo sapiens_hsa051440.34386329
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34235543
127Pyruvate metabolism_Homo sapiens_hsa006200.34084584
128Notch signaling pathway_Homo sapiens_hsa043300.32978281
129Basal cell carcinoma_Homo sapiens_hsa052170.32734816
130HTLV-I infection_Homo sapiens_hsa051660.30532994
131TGF-beta signaling pathway_Homo sapiens_hsa043500.30343363
132Huntingtons disease_Homo sapiens_hsa050160.29528938
133Thyroid cancer_Homo sapiens_hsa052160.29118001
134MicroRNAs in cancer_Homo sapiens_hsa052060.28407850
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27908151
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27765458
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26088173
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.23485201
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22760425
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22438545
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22197289
142Small cell lung cancer_Homo sapiens_hsa052220.21498552
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21493016
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20977959
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18286395
146Fatty acid biosynthesis_Homo sapiens_hsa000610.16445231
147Systemic lupus erythematosus_Homo sapiens_hsa053220.16100300
148Renin-angiotensin system_Homo sapiens_hsa046140.16072078
149HIF-1 signaling pathway_Homo sapiens_hsa040660.15722684
150Tight junction_Homo sapiens_hsa045300.15071847
151Circadian rhythm_Homo sapiens_hsa047100.14748169
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13259595
153Bladder cancer_Homo sapiens_hsa052190.13161413
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11940271
155Apoptosis_Homo sapiens_hsa042100.09187695
156Pathways in cancer_Homo sapiens_hsa052000.08320311
157Legionellosis_Homo sapiens_hsa051340.07942801
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07467867
159Intestinal immune network for IgA production_Homo sapiens_hsa046720.05996797
160Mineral absorption_Homo sapiens_hsa049780.05491669
161beta-Alanine metabolism_Homo sapiens_hsa004100.04222335
162Central carbon metabolism in cancer_Homo sapiens_hsa052300.04053617
163Adherens junction_Homo sapiens_hsa045200.04040905
164Glycerolipid metabolism_Homo sapiens_hsa005610.01931734
165FoxO signaling pathway_Homo sapiens_hsa040680.01881731
166Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.01233078
167Wnt signaling pathway_Homo sapiens_hsa04310-0.0108357

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