HSD17B10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.22663501
2L-phenylalanine catabolic process (GO:0006559)6.22663501
3L-phenylalanine metabolic process (GO:0006558)6.15412248
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.15412248
5glyoxylate metabolic process (GO:0046487)5.18514353
6aromatic amino acid family catabolic process (GO:0009074)5.12622549
7proteasome assembly (GO:0043248)4.82011161
8sulfur amino acid catabolic process (GO:0000098)4.61570256
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.60864199
10bile acid biosynthetic process (GO:0006699)4.45565580
11serine family amino acid biosynthetic process (GO:0009070)4.36163623
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.32808096
13aldehyde catabolic process (GO:0046185)4.32117532
14regulation of mitochondrial translation (GO:0070129)4.30279637
15alpha-linolenic acid metabolic process (GO:0036109)4.29970801
16negative regulation of ligase activity (GO:0051352)4.29186350
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.29186350
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27865887
19indole-containing compound catabolic process (GO:0042436)4.23275648
20indolalkylamine catabolic process (GO:0046218)4.23275648
21tryptophan catabolic process (GO:0006569)4.23275648
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.22883600
23regulation of cellular amino acid metabolic process (GO:0006521)4.21082545
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.19201199
25cysteine metabolic process (GO:0006534)4.10219746
26kynurenine metabolic process (GO:0070189)4.09620636
27fatty acid beta-oxidation (GO:0006635)4.06637339
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.04945626
29cellular ketone body metabolic process (GO:0046950)4.04714853
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.02340188
31chaperone-mediated protein transport (GO:0072321)4.00539975
32ribosomal small subunit assembly (GO:0000028)4.00293208
33L-serine metabolic process (GO:0006563)3.98335502
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.98006624
35tryptophan metabolic process (GO:0006568)3.97594406
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.96326323
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.96326323
38maturation of SSU-rRNA (GO:0030490)3.95813731
39protein maturation by protein folding (GO:0022417)3.95277695
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.94639222
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.94639222
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.94639222
43* branched-chain amino acid catabolic process (GO:0009083)3.93684106
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.93159086
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.93159086
46short-chain fatty acid metabolic process (GO:0046459)3.90700691
47regulation of triglyceride catabolic process (GO:0010896)3.90359760
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.85840080
49establishment of integrated proviral latency (GO:0075713)3.83742313
50formation of translation preinitiation complex (GO:0001731)3.82145199
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81735672
52serine family amino acid metabolic process (GO:0009069)3.81523121
53fatty acid catabolic process (GO:0009062)3.80703829
54lysine metabolic process (GO:0006553)3.80380240
55lysine catabolic process (GO:0006554)3.80380240
56glycine metabolic process (GO:0006544)3.80048638
57protein targeting to mitochondrion (GO:0006626)3.80008062
58ribosomal large subunit biogenesis (GO:0042273)3.77383815
59very long-chain fatty acid metabolic process (GO:0000038)3.76487883
60aromatic amino acid family metabolic process (GO:0009072)3.74833366
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74526816
62serine family amino acid catabolic process (GO:0009071)3.72649309
63alpha-amino acid catabolic process (GO:1901606)3.72380253
64DNA strand elongation involved in DNA replication (GO:0006271)3.72215159
65amino-acid betaine metabolic process (GO:0006577)3.72214495
66fatty acid oxidation (GO:0019395)3.71086296
67valine metabolic process (GO:0006573)3.71032417
68translational elongation (GO:0006414)3.68560661
69ethanol oxidation (GO:0006069)3.68548670
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67342631
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.65597572
72cotranslational protein targeting to membrane (GO:0006613)3.65042992
73telomere maintenance via semi-conservative replication (GO:0032201)3.64832234
74lipid oxidation (GO:0034440)3.64376249
75protein targeting to ER (GO:0045047)3.64113359
76bile acid metabolic process (GO:0008206)3.63141524
77high-density lipoprotein particle remodeling (GO:0034375)3.61761333
78oxidative phosphorylation (GO:0006119)3.59560468
79coenzyme catabolic process (GO:0009109)3.58860713
80monocarboxylic acid catabolic process (GO:0072329)3.58158795
81DNA strand elongation (GO:0022616)3.57327955
82* cellular amino acid catabolic process (GO:0009063)3.55745728
83negative regulation of fibrinolysis (GO:0051918)3.55451663
84regulation of fibrinolysis (GO:0051917)3.55148163
85establishment of protein localization to mitochondrion (GO:0072655)3.53500023
86positive regulation of ligase activity (GO:0051351)3.52304431
87spliceosomal snRNP assembly (GO:0000387)3.51442670
88cofactor catabolic process (GO:0051187)3.50329789
89translation (GO:0006412)3.50133415
90homocysteine metabolic process (GO:0050667)3.50059662
91regulation of cholesterol esterification (GO:0010872)3.49790649
92protein localization to endoplasmic reticulum (GO:0070972)3.49586382
93response to nitrosative stress (GO:0051409)3.48559088
94GTP biosynthetic process (GO:0006183)3.48403697
95* branched-chain amino acid metabolic process (GO:0009081)3.48342371
96ketone body metabolic process (GO:1902224)3.47433206
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46117570
98* carboxylic acid catabolic process (GO:0046395)3.46037509
99* organic acid catabolic process (GO:0016054)3.46037509
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45899369
101establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45661615
102ribonucleoprotein complex biogenesis (GO:0022613)3.45001763
103establishment of viral latency (GO:0019043)3.44574850
104UTP biosynthetic process (GO:0006228)3.44458610
105guanosine-containing compound biosynthetic process (GO:1901070)3.43919974
106pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.43678342
107viral transcription (GO:0019083)3.43381389
108respiratory electron transport chain (GO:0022904)3.42950476
109ATP synthesis coupled proton transport (GO:0015986)3.40818353
110energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40818353
111protein localization to mitochondrion (GO:0070585)3.40027628
112rRNA modification (GO:0000154)3.38689097
113protein complex biogenesis (GO:0070271)3.38311140
114urea cycle (GO:0000050)3.37697755
115urea metabolic process (GO:0019627)3.37697755
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.37645060
117cullin deneddylation (GO:0010388)3.37510587
118peptidyl-arginine omega-N-methylation (GO:0035247)3.37108517
119tyrosine metabolic process (GO:0006570)3.35136733
120electron transport chain (GO:0022900)3.34071199
121regulation of ubiquitin-protein transferase activity (GO:0051438)3.33283094
122translational initiation (GO:0006413)3.32927483
123pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.32336787
124termination of RNA polymerase III transcription (GO:0006386)3.32137794
125transcription elongation from RNA polymerase III promoter (GO:0006385)3.32137794
126ribosomal small subunit biogenesis (GO:0042274)3.32127970
127nucleobase-containing small molecule interconversion (GO:0015949)3.30977444
128base-excision repair, AP site formation (GO:0006285)3.30104672
129mitochondrial respiratory chain complex assembly (GO:0033108)3.29360332
130acetyl-CoA metabolic process (GO:0006084)3.28818036
131pseudouridine synthesis (GO:0001522)3.28542797
132complement activation, alternative pathway (GO:0006957)3.28041271
133protein deneddylation (GO:0000338)3.27497422
134cellular component biogenesis (GO:0044085)3.26999161
135aspartate family amino acid catabolic process (GO:0009068)3.26583378
136peptidyl-glutamic acid carboxylation (GO:0017187)3.25961864
137protein carboxylation (GO:0018214)3.25961864
138translational termination (GO:0006415)3.25896379
139heme transport (GO:0015886)3.24719830
140regulation of ligase activity (GO:0051340)3.23487735
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22253177
142acylglycerol homeostasis (GO:0055090)3.21903706
143triglyceride homeostasis (GO:0070328)3.21903706
144thioester metabolic process (GO:0035383)3.21406761
145acyl-CoA metabolic process (GO:0006637)3.21406761
146nitrogen cycle metabolic process (GO:0071941)3.21343107
147rRNA processing (GO:0006364)3.21111289
148regulation of protein activation cascade (GO:2000257)3.20584173
149pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20478896
150CTP metabolic process (GO:0046036)3.19194703
151CTP biosynthetic process (GO:0006241)3.19194703
152pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17968196
153viral life cycle (GO:0019058)3.17916131
154UTP metabolic process (GO:0046051)3.17746277
155blood coagulation, intrinsic pathway (GO:0007597)3.16399786
156regulation of cholesterol metabolic process (GO:0090181)3.16379570
157regulation of cellular amine metabolic process (GO:0033238)3.16033521
158benzene-containing compound metabolic process (GO:0042537)3.14299930
159mitochondrial respiratory chain complex I assembly (GO:0032981)3.13892592
160NADH dehydrogenase complex assembly (GO:0010257)3.13892592
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13892592
162positive regulation of cell cycle arrest (GO:0071158)3.12705892
163purine nucleobase biosynthetic process (GO:0009113)3.12018975
164plasma lipoprotein particle remodeling (GO:0034369)3.11890856
165protein-lipid complex remodeling (GO:0034368)3.11890856
166macromolecular complex remodeling (GO:0034367)3.11890856
167antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.11096162
168ribosome biogenesis (GO:0042254)3.09139952
169GDP-mannose metabolic process (GO:0019673)3.07939222
170histone arginine methylation (GO:0034969)3.07774566
171fatty acid elongation (GO:0030497)3.07674287
172carnitine metabolic process (GO:0009437)3.07422508
173pentose metabolic process (GO:0019321)3.07227679
174amine catabolic process (GO:0009310)3.06472018
175cellular biogenic amine catabolic process (GO:0042402)3.06472018
176imidazole-containing compound metabolic process (GO:0052803)3.06054421
177arginine metabolic process (GO:0006525)3.05820045
178ribosome assembly (GO:0042255)3.05500917
179reverse cholesterol transport (GO:0043691)3.04683251
180positive regulation of triglyceride lipase activity (GO:0061365)3.04628011
181positive regulation of lipoprotein lipase activity (GO:0051006)3.04628011
182nucleobase biosynthetic process (GO:0046112)3.04586711
183cellular glucuronidation (GO:0052695)3.03770926
184rRNA metabolic process (GO:0016072)3.03636621
185xenobiotic catabolic process (GO:0042178)3.01162136
186bile acid and bile salt transport (GO:0015721)2.99927269
187negative regulation of sterol transport (GO:0032372)2.99667482
188negative regulation of cholesterol transport (GO:0032375)2.99667482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.84367515
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.64172886
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.18624457
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.66683936
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.54651011
6E2F7_22180533_ChIP-Seq_HELA_Human4.03576812
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91832322
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.68893126
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.65433223
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.27104840
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18564496
12* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95526575
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86012945
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81734513
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63242085
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.49387218
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38144493
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30746060
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27195745
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23661095
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22418541
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.20648243
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20182841
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15294304
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10210450
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.05905467
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94291022
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.93136485
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.92004060
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90755340
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82603687
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78930418
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71691952
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.70201919
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68498860
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64056242
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.60948294
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56894120
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54835280
40KDM5A_27292631_Chip-Seq_BREAST_Human1.54227887
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53279608
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50296368
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49571760
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49039678
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.48820905
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47916422
47ZNF263_19887448_ChIP-Seq_K562_Human1.45510943
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44777706
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40174491
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40056901
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39441801
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37966093
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30471256
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.28121185
55DCP1A_22483619_ChIP-Seq_HELA_Human1.26956953
56XRN2_22483619_ChIP-Seq_HELA_Human1.26722942
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24550169
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24342830
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20554215
60CIITA_25753668_ChIP-Seq_RAJI_Human1.19591792
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.19369485
62FOXP3_21729870_ChIP-Seq_TREG_Human1.19008200
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17691891
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17465800
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16475927
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.16174023
67CLOCK_20551151_ChIP-Seq_293T_Human1.14370909
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14071169
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12572606
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12470427
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12041900
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11339871
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11266178
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11262857
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11136531
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09943558
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08745340
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07452522
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07341259
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06541623
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06080847
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05394769
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05049089
84TFEB_21752829_ChIP-Seq_HELA_Human1.04856323
85VDR_23849224_ChIP-Seq_CD4+_Human1.04787918
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.04317947
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04059404
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02044228
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01023853
90SCL_19346495_ChIP-Seq_HPC-7_Human1.00208796
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99915659
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99792901
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98465912
94HTT_18923047_ChIP-ChIP_STHdh_Human0.97913524
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97244043
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96947760
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96374404
98MYC_18940864_ChIP-ChIP_HL60_Human0.96331914
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94403419
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93703801
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93408933
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92435404
103MYC_22102868_ChIP-Seq_BL_Human0.90667269
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.89943303
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89375425
106* GABP_19822575_ChIP-Seq_HepG2_Human0.89312851
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.88829500
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88301678
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87973445
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87799485
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87527128
112CTCF_26484167_Chip-Seq_Bcells_Mouse0.87478961
113YY1_21170310_ChIP-Seq_MESCs_Mouse0.86379540
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86181991
115ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85335584
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84809290
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81474829
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80913610
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.80473459
120AR_21909140_ChIP-Seq_LNCAP_Human0.79695985
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78820908
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78346316
123ELK1_19687146_ChIP-ChIP_HELA_Human0.78247704
124AR_20517297_ChIP-Seq_VCAP_Human0.77548477
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77280352
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76848637
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76696996
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75520927
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74961092
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74709078
131GATA1_22025678_ChIP-Seq_K562_Human0.74376023
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74236825
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.72772397
134GATA4_25053715_ChIP-Seq_YYC3_Human0.72228341
135TTF2_22483619_ChIP-Seq_HELA_Human0.71355092
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.70941985
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70314217
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69883237
139ERG_20517297_ChIP-Seq_VCAP_Human0.67300460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.24314542
2MP0003806_abnormal_nucleotide_metabolis5.76985052
3MP0005360_urolithiasis5.76701469
4MP0005085_abnormal_gallbladder_physiolo5.09843717
5MP0005365_abnormal_bile_salt5.00493204
6MP0003693_abnormal_embryo_hatching4.59329761
7MP0008875_abnormal_xenobiotic_pharmacok4.09382080
8MP0008058_abnormal_DNA_repair4.06735892
9MP0004957_abnormal_blastocyst_morpholog3.99569722
10MP0010094_abnormal_chromosome_stability3.83712972
11MP0003111_abnormal_nucleus_morphology3.68269123
12MP0008932_abnormal_embryonic_tissue3.21105094
13MP0003077_abnormal_cell_cycle3.13471906
14MP0005332_abnormal_amino_acid2.86822323
15MP0009840_abnormal_foam_cell2.77998926
16MP0005083_abnormal_biliary_tract2.74956923
17MP0003195_calcinosis2.73297799
18MP0003786_premature_aging2.70196842
19MP0010329_abnormal_lipoprotein_level2.58394192
20MP0003186_abnormal_redox_activity2.55391111
21MP0003252_abnormal_bile_duct2.38324328
22MP0008007_abnormal_cellular_replicative2.30873241
23MP0001666_abnormal_nutrient_absorption2.27575809
24MP0003011_delayed_dark_adaptation2.22184590
25MP0006036_abnormal_mitochondrial_physio2.06011203
26MP0003191_abnormal_cellular_cholesterol1.90571308
27MP0009379_abnormal_foot_pigmentation1.87547883
28MP0009697_abnormal_copulation1.83659909
29MP0004019_abnormal_vitamin_homeostasis1.83158196
30MP0002118_abnormal_lipid_homeostasis1.72979460
31MP0005319_abnormal_enzyme/_coenzyme1.70228812
32MP0001764_abnormal_homeostasis1.68345763
33MP0005408_hypopigmentation1.68072154
34MP0001730_embryonic_growth_arrest1.62910874
35MP0003656_abnormal_erythrocyte_physiolo1.60684144
36MP0000609_abnormal_liver_physiology1.59285395
37MP0009643_abnormal_urine_homeostasis1.56637954
38MP0000358_abnormal_cell_content/1.52584913
39MP0005584_abnormal_enzyme/coenzyme_acti1.52574555
40MP0002877_abnormal_melanocyte_morpholog1.46746135
41MP0002163_abnormal_gland_morphology1.45934424
42MP0000350_abnormal_cell_proliferation1.41865569
43MP0005501_abnormal_skin_physiology1.40821421
44MP0004381_abnormal_hair_follicle1.39599523
45MP0005451_abnormal_body_composition1.38527022
46MP0001727_abnormal_embryo_implantation1.36300139
47MP0000313_abnormal_cell_death1.35834945
48MP0004147_increased_porphyrin_level1.35108555
49MP0008789_abnormal_olfactory_epithelium1.23421063
50MP0005075_abnormal_melanosome_morpholog1.23008244
51MP0000490_abnormal_crypts_of1.22814524
52MP0003868_abnormal_feces_composition1.20242441
53MP0002132_abnormal_respiratory_system1.17488135
54MP0002080_prenatal_lethality1.17276173
55MP0002138_abnormal_hepatobiliary_system1.16464666
56MP0002019_abnormal_tumor_incidence1.15150066
57MP0005636_abnormal_mineral_homeostasis1.13392139
58MP0006035_abnormal_mitochondrial_morpho1.10404572
59MP0000598_abnormal_liver_morphology1.09700948
60MP0001881_abnormal_mammary_gland1.08724129
61MP0000678_abnormal_parathyroid_gland1.07648917
62MP0005330_cardiomyopathy1.06629095
63MP0001697_abnormal_embryo_size1.05365281
64MP0002796_impaired_skin_barrier1.05097655
65MP0010368_abnormal_lymphatic_system1.04885470
66MP0006292_abnormal_olfactory_placode1.04857967
67MP0002837_dystrophic_cardiac_calcinosis0.99875867
68MP0001529_abnormal_vocalization0.99366074
69MP0008260_abnormal_autophagy0.97860353
70MP0005266_abnormal_metabolism0.96951012
71MP0005084_abnormal_gallbladder_morpholo0.96357967
72MP0008469_abnormal_protein_level0.95438894
73MP0001672_abnormal_embryogenesis/_devel0.95403636
74MP0005380_embryogenesis_phenotype0.95403636
75MP0005376_homeostasis/metabolism_phenot0.94423152
76MP0004233_abnormal_muscle_weight0.94031396
77MP0009763_increased_sensitivity_to0.93788968
78MP0002938_white_spotting0.88624155
79MP0009672_abnormal_birth_weight0.88348739
80MP0005379_endocrine/exocrine_gland_phen0.86444927
81MP0008995_early_reproductive_senescence0.86399843
82MP0005670_abnormal_white_adipose0.85964856
83MP0000749_muscle_degeneration0.85756248
84MP0001346_abnormal_lacrimal_gland0.85595449
85MP0002234_abnormal_pharynx_morphology0.85294730
86MP0002210_abnormal_sex_determination0.84692517
87MP0003123_paternal_imprinting0.83374580
88MP0001919_abnormal_reproductive_system0.83193756
89MP0000049_abnormal_middle_ear0.82106476
90MP0003718_maternal_effect0.81672268
91MP0003724_increased_susceptibility_to0.79823516
92MP0000372_irregular_coat_pigmentation0.77971505
93MP0004043_abnormal_pH_regulation0.77360164
94MP0009642_abnormal_blood_homeostasis0.76198961
95MP0003984_embryonic_growth_retardation0.75892257
96MP0005647_abnormal_sex_gland0.75846132
97MP0001145_abnormal_male_reproductive0.75420180
98MP0002160_abnormal_reproductive_system0.75302608
99MP0002085_abnormal_embryonic_tissue0.73751143
100MP0004185_abnormal_adipocyte_glucose0.73574638
101MP0003567_abnormal_fetal_cardiomyocyte0.73545218
102MP0006072_abnormal_retinal_apoptosis0.72836542
103MP0001853_heart_inflammation0.72810346
104MP0010234_abnormal_vibrissa_follicle0.70722494
105MP0009764_decreased_sensitivity_to0.70191590
106MP0002088_abnormal_embryonic_growth/wei0.69928670
107MP0005499_abnormal_olfactory_system0.68679102
108MP0005394_taste/olfaction_phenotype0.68679102
109MP0002249_abnormal_larynx_morphology0.68362041
110MP0001929_abnormal_gametogenesis0.67715611
111MP0001293_anophthalmia0.67194158
112MP0009765_abnormal_xenobiotic_induced0.65584154
113MP0001348_abnormal_lacrimal_gland0.65311379
114MP0001756_abnormal_urination0.65036767
115MP0009785_altered_susceptibility_to0.64857390
116MP0004130_abnormal_muscle_cell0.64831604
117MP0000467_abnormal_esophagus_morphology0.64666652
118MP0001905_abnormal_dopamine_level0.64242578
119MP0000653_abnormal_sex_gland0.63446956
120MP0002136_abnormal_kidney_physiology0.61487587
121MP0000858_altered_metastatic_potential0.61193446
122MP0002111_abnormal_tail_morphology0.60753410
123MP0001544_abnormal_cardiovascular_syste0.60539410
124MP0005385_cardiovascular_system_phenoty0.60539410
125MP0003638_abnormal_response/metabolism_0.59771915
126MP0000566_synostosis0.59691525
127MP0002971_abnormal_brown_adipose0.58473387
128MP0000343_altered_response_to0.58077325
129MP0010030_abnormal_orbit_morphology0.57363966
130MP0005165_increased_susceptibility_to0.55831739
131MP0004782_abnormal_surfactant_physiolog0.54793874
132MP0003221_abnormal_cardiomyocyte_apopto0.53719887
133MP0000537_abnormal_urethra_morphology0.53296775
134MP0005058_abnormal_lysosome_morphology0.53180131
135MP0005464_abnormal_platelet_physiology0.53113049
136MP0005395_other_phenotype0.52341204
137MP0003646_muscle_fatigue0.50679839
138MP0005666_abnormal_adipose_tissue0.50234063
139MP0005220_abnormal_exocrine_pancreas0.50120165
140MP0002269_muscular_atrophy0.48930330
141MP0004036_abnormal_muscle_relaxation0.47615789
142MP0000230_abnormal_systemic_arterial0.47597380
143MP0010630_abnormal_cardiac_muscle0.46458426
144MP0008873_increased_physiological_sensi0.45311033
145MP0008775_abnormal_heart_ventricle0.45255407
146MP0002933_joint_inflammation0.44771698
147MP0006138_congestive_heart_failure0.44242642
148MP0003942_abnormal_urinary_system0.42540010
149MP0002078_abnormal_glucose_homeostasis0.41904503
150MP0003315_abnormal_perineum_morphology0.41458820
151MP0009053_abnormal_anal_canal0.40882825
152MP0005334_abnormal_fat_pad0.40865382
153MP0001661_extended_life_span0.40474323
154MP0009333_abnormal_splenocyte_physiolog0.40113581
155MP0002060_abnormal_skin_morphology0.39206856
156MP0000747_muscle_weakness0.38927627
157MP0000639_abnormal_adrenal_gland0.37617283
158MP0004084_abnormal_cardiac_muscle0.36852535

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.98222168
2Intrahepatic cholestasis (HP:0001406)4.83705319
3Abnormality of fatty-acid metabolism (HP:0004359)4.36201927
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.35015774
5Hyperammonemia (HP:0001987)4.33646947
6Hepatic necrosis (HP:0002605)4.21295512
7Hypobetalipoproteinemia (HP:0003563)4.12767057
8Prolonged partial thromboplastin time (HP:0003645)4.07619390
9Xanthomatosis (HP:0000991)4.05848397
10Deep venous thrombosis (HP:0002625)4.01016389
11Abnormality of dicarboxylic acid metabolism (HP:0010995)3.98628901
12Dicarboxylic aciduria (HP:0003215)3.98628901
13Hyperlipoproteinemia (HP:0010980)3.97842530
14Cerebral edema (HP:0002181)3.94601425
15Hyperglycinemia (HP:0002154)3.93585772
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.92119629
17Abnormality of serine family amino acid metabolism (HP:0010894)3.92105542
18Abnormality of glycine metabolism (HP:0010895)3.92105542
19Acute encephalopathy (HP:0006846)3.88363839
20Microvesicular hepatic steatosis (HP:0001414)3.83581586
21Hyperglycinuria (HP:0003108)3.83484874
22Hepatocellular necrosis (HP:0001404)3.72774049
23Ketosis (HP:0001946)3.54991324
24Acute necrotizing encephalopathy (HP:0006965)3.51180638
25Reticulocytopenia (HP:0001896)3.49744580
26Hypoglycemic coma (HP:0001325)3.48681907
27Abnormal mitochondria in muscle tissue (HP:0008316)3.47397553
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.44903847
29Mitochondrial inheritance (HP:0001427)3.40424417
30Lethargy (HP:0001254)3.37341510
31Abnormality of methionine metabolism (HP:0010901)3.33551838
32Increased CSF lactate (HP:0002490)3.31414789
33Increased muscle lipid content (HP:0009058)3.30325995
34Lipid accumulation in hepatocytes (HP:0006561)3.25373362
35Generalized aminoaciduria (HP:0002909)3.16438239
36Type I transferrin isoform profile (HP:0003642)3.13122365
37Abnormality of glycolysis (HP:0004366)3.12847061
38Increased serum pyruvate (HP:0003542)3.12847061
393-Methylglutaconic aciduria (HP:0003535)3.12742744
40Hypolipoproteinemia (HP:0010981)3.03137433
41Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00814945
42Joint hemorrhage (HP:0005261)3.00660743
43Abnormality of serum amino acid levels (HP:0003112)2.99792909
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.99099523
45Increased intramyocellular lipid droplets (HP:0012240)2.97816768
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93388099
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.88335327
48* Lactic acidosis (HP:0003128)2.87493947
49* Metabolic acidosis (HP:0001942)2.83399354
50Rough bone trabeculation (HP:0100670)2.81677095
51Renal Fanconi syndrome (HP:0001994)2.80689595
52Respiratory difficulties (HP:0002880)2.79195662
53Fat malabsorption (HP:0002630)2.77436311
54Glycosuria (HP:0003076)2.76057341
55Abnormality of urine glucose concentration (HP:0011016)2.76057341
56Progressive macrocephaly (HP:0004481)2.74306890
57Delayed CNS myelination (HP:0002188)2.74016626
58Complement deficiency (HP:0004431)2.73884526
59Increased hepatocellular lipid droplets (HP:0006565)2.71653062
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.71423344
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71228672
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71228672
63Ketoacidosis (HP:0001993)2.69890427
64Increased serum lactate (HP:0002151)2.69097924
65Hyperbilirubinemia (HP:0002904)2.65619660
66Degeneration of anterior horn cells (HP:0002398)2.65566825
67Abnormality of the anterior horn cell (HP:0006802)2.65566825
68Nausea (HP:0002018)2.63503233
69Vomiting (HP:0002013)2.62860330
70Cholecystitis (HP:0001082)2.61542428
71Abnormal gallbladder physiology (HP:0012438)2.61542428
72Epidermoid cyst (HP:0200040)2.59914931
73Abnormality of pyrimidine metabolism (HP:0004353)2.58743462
74Microretrognathia (HP:0000308)2.54851179
75Hypoalphalipoproteinemia (HP:0003233)2.54739066
76Pancytopenia (HP:0001876)2.50121755
77Respiratory failure (HP:0002878)2.49377395
78Testicular atrophy (HP:0000029)2.48824308
79Reduced antithrombin III activity (HP:0001976)2.48161535
80Abnormality of the common coagulation pathway (HP:0010990)2.46872057
81Abnormality of the intrinsic pathway (HP:0010989)2.46134456
82Proximal tubulopathy (HP:0000114)2.46086282
83Abnormal protein glycosylation (HP:0012346)2.42822805
84Abnormal glycosylation (HP:0012345)2.42822805
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42822805
86Abnormal protein N-linked glycosylation (HP:0012347)2.42822805
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39590789
88Abnormality of cells of the erythroid lineage (HP:0012130)2.38044824
89Aplastic anemia (HP:0001915)2.37741688
90Steatorrhea (HP:0002570)2.37236590
91Progressive muscle weakness (HP:0003323)2.36150485
92Methylmalonic aciduria (HP:0012120)2.34576923
93Hypokinesia (HP:0002375)2.29665095
94Ragged-red muscle fibers (HP:0003200)2.26605336
95Rhabdomyolysis (HP:0003201)2.24585853
96Myoglobinuria (HP:0002913)2.23447451
97Abnormal cartilage morphology (HP:0002763)2.22568263
98Hypercholesterolemia (HP:0003124)2.20927859
99Abnormal number of erythroid precursors (HP:0012131)2.19967976
100Vascular calcification (HP:0004934)2.19649827
101Spontaneous abortion (HP:0005268)2.18416114
102Abnormality of the heme biosynthetic pathway (HP:0010472)2.17752386
103Renal cortical cysts (HP:0000803)2.17751058
104Emotional lability (HP:0000712)2.16169373
105Exercise intolerance (HP:0003546)2.15689336
106Opisthotonus (HP:0002179)2.14544502
107Sparse eyelashes (HP:0000653)2.14338371
108CNS demyelination (HP:0007305)2.11694447
109Exertional dyspnea (HP:0002875)2.11314632
110Multiple enchondromatosis (HP:0005701)2.10807102
111Optic disc pallor (HP:0000543)2.10176086
112Abnormality of nucleobase metabolism (HP:0010932)2.10146696
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08497687
114Abnormality of alanine metabolism (HP:0010916)2.08497687
115Hyperalaninemia (HP:0003348)2.08497687
116Abnormal trabecular bone morphology (HP:0100671)2.07838936
117Cerebral hypomyelination (HP:0006808)2.05424467
118Oral leukoplakia (HP:0002745)2.04377513
119Hepatocellular carcinoma (HP:0001402)2.04050579
120Macrocytic anemia (HP:0001972)2.03939788
121Respiratory distress (HP:0002098)2.02790372
122Abnormality of the umbilical cord (HP:0010881)2.01329894
123Abnormal hemoglobin (HP:0011902)1.98281330
124Gout (HP:0001997)1.97407661
125Conjugated hyperbilirubinemia (HP:0002908)1.96747498
126Leukodystrophy (HP:0002415)1.96234571
127Hyperphosphaturia (HP:0003109)1.96174105
128Pallor (HP:0000980)1.95470935
129Brushfield spots (HP:0001088)1.95331680
130Enlarged kidneys (HP:0000105)1.95063619
131Methylmalonic acidemia (HP:0002912)1.93057860
132Late onset (HP:0003584)1.92610592
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92272249
134Amniotic constriction ring (HP:0009775)1.91242414
135Abnormality of placental membranes (HP:0011409)1.91242414
136Abnormality of complement system (HP:0005339)1.91025096
137Trismus (HP:0000211)1.89510866
138Congenital ichthyosiform erythroderma (HP:0007431)1.88918351
139Secondary amenorrhea (HP:0000869)1.82789617
140Death in infancy (HP:0001522)1.82318099
141Abnormalities of placenta or umbilical cord (HP:0001194)1.80576982
142Selective tooth agenesis (HP:0001592)1.80159154
143Prolonged neonatal jaundice (HP:0006579)1.79675947
144Spastic diplegia (HP:0001264)1.78237121
145Cholelithiasis (HP:0001081)1.77659533
146Colon cancer (HP:0003003)1.76667257
147Abnormality of renal resorption (HP:0011038)1.73455033
148Abnormality of reticulocytes (HP:0004312)1.73054853
149Premature ovarian failure (HP:0008209)1.68056955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.28824845
2VRK25.76153055
3NME23.97899042
4MUSK3.11100624
5SMG12.56397132
6TESK12.41034940
7MYLK2.39791524
8STK162.36909831
9ERN12.28039355
10CDC72.10878879
11PBK2.05427112
12KDR2.03021530
13SIK12.02753472
14EIF2AK11.96090452
15TIE11.89761073
16FLT31.80491010
17TAF11.79328092
18PIK3CA1.65741869
19SCYL21.64366537
20TGFBR11.58748897
21OBSCN1.57910499
22LIMK11.57459084
23BUB11.50856406
24MAP3K31.45381518
25MAP2K31.43541001
26PIM21.43161484
27TTK1.42920075
28STK391.42755768
29ABL21.42483461
30ARAF1.33823516
31AURKA1.29666251
32LRRK21.28473543
33PAK41.27354944
34DAPK11.27057579
35NEK91.26523454
36VRK11.22696373
37MAP3K121.22158720
38FGFR41.21293587
39TGFBR21.15966609
40MST1R1.14514085
41BRSK11.12746490
42PINK11.12449131
43MET1.07233409
44MAP2K61.06909543
45TSSK61.06343525
46MAPK41.05634733
47LMTK21.05071868
48MAPKAPK51.04440956
49EPHB11.03737077
50PLK11.03298572
51CHEK21.03116328
52TRIB31.01509629
53KIT1.00710581
54CSNK1A1L1.00511902
55CDK80.99828644
56TEC0.97299313
57ATR0.96973404
58EIF2AK30.96518828
59PLK30.94289324
60ILK0.93586448
61WEE10.91273129
62PRKG20.90383528
63CDK190.90210502
64MAP2K20.89895139
65PIK3CG0.89511106
66BTK0.88655881
67MKNK10.86521676
68WNK40.85977408
69CSNK1G20.82301921
70RPS6KB20.81256545
71GRK70.80449546
72MAPKAPK30.80220492
73MAPK110.79498246
74OXSR10.78545763
75MAP3K110.77855687
76MST40.76360840
77EPHA20.75847366
78TLK10.75275565
79DAPK30.74861397
80TESK20.74830759
81ERBB40.74747736
82IRAK30.72807902
83STK40.71119620
84PDK20.70370324
85TAOK20.70179172
86PRKCI0.69904997
87PKN20.69131704
88PDK40.68689655
89PDK30.68689655
90TBK10.68389465
91MAP3K80.64990999
92NEK10.64174077
93PIM10.62810218
94TTN0.62369660
95STK38L0.60524371
96CAMK2G0.59586517
97CHEK10.59193134
98BRAF0.58764694
99ADRBK20.57411875
100CSNK1G30.56211027
101PAK10.55677268
102CDK40.54745314
103ZAK0.54691617
104CSF1R0.54550570
105CSNK2A10.53589727
106CSNK1G10.52858497
107AKT20.52415673
108RPS6KA50.52149068
109TYK20.52108860
110DYRK20.51474566
111BMPR1B0.51421698
112TRIM280.51376620
113PLK40.49824280
114PASK0.49818228
115PKN10.49345926
116CCNB10.48930259
117MAPK120.48885658
118NME10.48869334
119ZAP700.48305563
120RPS6KA40.47579701
121EIF2AK20.47454443
122IKBKB0.47274206
123MAP2K70.47125699
124MAP4K10.46433503
125DYRK30.45552542
126CAMK2D0.43968069
127CDK90.43929749
128GRK10.41516362
129SRPK10.40319630
130YES10.40273138
131DYRK1B0.39989061
132IKBKE0.39642042
133CDK70.39251193
134AURKB0.38629454
135CDK11A0.38499075
136LYN0.36903794
137PRKD30.35668145
138CSNK2A20.35450264
139NUAK10.35334186
140CDK140.35012183
141STK240.33895304
142BLK0.33686527
143GRK60.33241459
144PRKCD0.31382934
145CDK150.30612428
146CDK180.30359771
147STK100.27387105
148ATM0.24196637
149NEK20.23834388
150CDK20.23526466
151CLK10.23484480
152IRAK40.23253773
153IRAK20.22799578

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.11785142
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.86662673
3* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73127455
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58469856
5Fatty acid elongation_Homo sapiens_hsa000622.58159477
6Fatty acid degradation_Homo sapiens_hsa000712.50003675
7Propanoate metabolism_Homo sapiens_hsa006402.49290842
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47418563
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30169832
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21894884
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21224888
12Ribosome_Homo sapiens_hsa030102.16584736
13Sulfur metabolism_Homo sapiens_hsa009202.03519113
14Peroxisome_Homo sapiens_hsa041462.02709603
15Tryptophan metabolism_Homo sapiens_hsa003802.02182125
16Butanoate metabolism_Homo sapiens_hsa006502.00248357
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98613780
18Fatty acid metabolism_Homo sapiens_hsa012121.92040894
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88244866
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87892334
21Oxidative phosphorylation_Homo sapiens_hsa001901.85662417
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85012584
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83092696
24Nitrogen metabolism_Homo sapiens_hsa009101.80679263
25Arginine biosynthesis_Homo sapiens_hsa002201.79362991
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79025081
27Chemical carcinogenesis_Homo sapiens_hsa052041.77745050
28Parkinsons disease_Homo sapiens_hsa050121.72496661
29Histidine metabolism_Homo sapiens_hsa003401.71374973
30Folate biosynthesis_Homo sapiens_hsa007901.67548485
31Pyruvate metabolism_Homo sapiens_hsa006201.61174969
32Complement and coagulation cascades_Homo sapiens_hsa046101.59655270
33beta-Alanine metabolism_Homo sapiens_hsa004101.59088038
34Carbon metabolism_Homo sapiens_hsa012001.55024466
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54342390
36PPAR signaling pathway_Homo sapiens_hsa033201.54182715
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.52698178
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.48168304
39RNA transport_Homo sapiens_hsa030131.43276328
40Sulfur relay system_Homo sapiens_hsa041221.40460936
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38321530
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.34234430
43Retinol metabolism_Homo sapiens_hsa008301.33880966
44Selenocompound metabolism_Homo sapiens_hsa004501.33080110
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31971250
46Biosynthesis of amino acids_Homo sapiens_hsa012301.31597773
47Phenylalanine metabolism_Homo sapiens_hsa003601.30752409
48Glutathione metabolism_Homo sapiens_hsa004801.30745447
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29646874
50Steroid biosynthesis_Homo sapiens_hsa001001.29355042
51Tyrosine metabolism_Homo sapiens_hsa003501.23941681
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.15278461
53Fanconi anemia pathway_Homo sapiens_hsa034601.13232972
54Proteasome_Homo sapiens_hsa030501.11359255
55Arginine and proline metabolism_Homo sapiens_hsa003301.10126801
56One carbon pool by folate_Homo sapiens_hsa006701.08325766
57Caffeine metabolism_Homo sapiens_hsa002321.07711343
58Alzheimers disease_Homo sapiens_hsa050101.03309543
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00442461
60Huntingtons disease_Homo sapiens_hsa050160.99912266
61Fat digestion and absorption_Homo sapiens_hsa049750.99416241
62Cell cycle_Homo sapiens_hsa041100.98848767
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98353980
64RNA degradation_Homo sapiens_hsa030180.97200592
65Starch and sucrose metabolism_Homo sapiens_hsa005000.96157349
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93595118
67* Metabolic pathways_Homo sapiens_hsa011000.82947442
68Protein export_Homo sapiens_hsa030600.82588900
69Staphylococcus aureus infection_Homo sapiens_hsa051500.81716884
70Pentose phosphate pathway_Homo sapiens_hsa000300.81188116
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79757040
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75384943
73Vitamin B6 metabolism_Homo sapiens_hsa007500.73451647
74N-Glycan biosynthesis_Homo sapiens_hsa005100.71458311
75Basal transcription factors_Homo sapiens_hsa030220.70289922
76Pyrimidine metabolism_Homo sapiens_hsa002400.66446806
77Vitamin digestion and absorption_Homo sapiens_hsa049770.66033846
78ABC transporters_Homo sapiens_hsa020100.62434770
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.61689175
80Bile secretion_Homo sapiens_hsa049760.61030209
81RNA polymerase_Homo sapiens_hsa030200.60392007
82Fructose and mannose metabolism_Homo sapiens_hsa000510.58107376
83DNA replication_Homo sapiens_hsa030300.56652545
84Linoleic acid metabolism_Homo sapiens_hsa005910.53658445
85Epstein-Barr virus infection_Homo sapiens_hsa051690.51527859
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50512912
87Glycerolipid metabolism_Homo sapiens_hsa005610.50505667
88Vibrio cholerae infection_Homo sapiens_hsa051100.49895153
89Arachidonic acid metabolism_Homo sapiens_hsa005900.48075954
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47930712
91Galactose metabolism_Homo sapiens_hsa000520.47565281
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45354065
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45266471
94mRNA surveillance pathway_Homo sapiens_hsa030150.44698399
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42404962
96Mismatch repair_Homo sapiens_hsa034300.42155234
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41930372
98p53 signaling pathway_Homo sapiens_hsa041150.41831772
99Cardiac muscle contraction_Homo sapiens_hsa042600.41623279
100Lysine degradation_Homo sapiens_hsa003100.30720033
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28043852
102Fatty acid biosynthesis_Homo sapiens_hsa000610.27050080
103Collecting duct acid secretion_Homo sapiens_hsa049660.25566050
104Primary immunodeficiency_Homo sapiens_hsa053400.23142675
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19743883
106Purine metabolism_Homo sapiens_hsa002300.18352579
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18183109
108Nucleotide excision repair_Homo sapiens_hsa034200.15411084
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14759373
110Shigellosis_Homo sapiens_hsa051310.14047339
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.12213230
112Base excision repair_Homo sapiens_hsa034100.12066028
113Oocyte meiosis_Homo sapiens_hsa041140.11258293
114Spliceosome_Homo sapiens_hsa030400.10054799
115Antigen processing and presentation_Homo sapiens_hsa046120.09052694
116Herpes simplex infection_Homo sapiens_hsa051680.08596403
117Non-homologous end-joining_Homo sapiens_hsa034500.04510531
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.03867475
119Systemic lupus erythematosus_Homo sapiens_hsa053220.03465900
120Ether lipid metabolism_Homo sapiens_hsa005650.03244262
121Homologous recombination_Homo sapiens_hsa034400.02624611

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