HSCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.48517418
2viral transcription (GO:0019083)5.75061021
3translational termination (GO:0006415)5.56569271
4ribosomal small subunit biogenesis (GO:0042274)5.50353014
5DNA deamination (GO:0045006)5.44367621
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.25181953
7maturation of SSU-rRNA (GO:0030490)5.21834219
8ATP synthesis coupled proton transport (GO:0015986)5.12464151
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.12464151
10translational elongation (GO:0006414)4.89586000
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.86563089
12cotranslational protein targeting to membrane (GO:0006613)4.77653239
13protein targeting to ER (GO:0045047)4.73385494
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.59924833
15behavioral response to nicotine (GO:0035095)4.56934578
16water-soluble vitamin biosynthetic process (GO:0042364)4.53032596
17protein localization to endoplasmic reticulum (GO:0070972)4.52283704
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.48950546
19viral life cycle (GO:0019058)4.35688053
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.32758498
21cellular protein complex disassembly (GO:0043624)4.29334171
22translational initiation (GO:0006413)4.28647986
23protein complex biogenesis (GO:0070271)4.16407161
24telomere maintenance via semi-conservative replication (GO:0032201)4.15816078
25electron transport chain (GO:0022900)4.03421677
26respiratory electron transport chain (GO:0022904)4.02311297
27protein neddylation (GO:0045116)4.00710188
28ribosomal large subunit biogenesis (GO:0042273)4.00274660
29platelet dense granule organization (GO:0060155)3.97628608
30chaperone-mediated protein transport (GO:0072321)3.93154314
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.90625672
32DNA strand elongation involved in DNA replication (GO:0006271)3.90409647
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.85736745
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.85736745
35mitochondrial respiratory chain complex assembly (GO:0033108)3.84906136
36DNA strand elongation (GO:0022616)3.80136279
37protein complex disassembly (GO:0043241)3.78680943
38telomere maintenance via recombination (GO:0000722)3.76576996
39ribonucleoprotein complex biogenesis (GO:0022613)3.70860635
40proteasome assembly (GO:0043248)3.63898834
41macromolecular complex disassembly (GO:0032984)3.60916332
42cytochrome complex assembly (GO:0017004)3.55987164
43translation (GO:0006412)3.53472084
44protein-cofactor linkage (GO:0018065)3.50285046
45formation of translation preinitiation complex (GO:0001731)3.47703798
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.46010910
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43434639
48protein K6-linked ubiquitination (GO:0085020)3.40254154
49mRNA catabolic process (GO:0006402)3.33840941
50mitotic recombination (GO:0006312)3.32503655
51definitive hemopoiesis (GO:0060216)3.31528849
52DNA replication initiation (GO:0006270)3.30547487
53peptidyl-histidine modification (GO:0018202)3.24386186
54RNA catabolic process (GO:0006401)3.21462375
55GTP biosynthetic process (GO:0006183)3.19352614
56CENP-A containing nucleosome assembly (GO:0034080)3.19073750
57cellular component biogenesis (GO:0044085)3.18260656
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.17569719
59termination of RNA polymerase III transcription (GO:0006386)3.17569719
60preassembly of GPI anchor in ER membrane (GO:0016254)3.13620268
61rRNA processing (GO:0006364)3.11059528
62L-fucose catabolic process (GO:0042355)3.07883419
63fucose catabolic process (GO:0019317)3.07883419
64L-fucose metabolic process (GO:0042354)3.07883419
65negative regulation of telomere maintenance (GO:0032205)3.07290747
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06857734
67telomere maintenance via telomere lengthening (GO:0010833)3.06773149
68chromatin remodeling at centromere (GO:0031055)3.05755432
69rRNA metabolic process (GO:0016072)3.05578414
70protein targeting to membrane (GO:0006612)3.05431753
71viral mRNA export from host cell nucleus (GO:0046784)3.03723480
72purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02094153
73kinetochore organization (GO:0051383)3.01975155
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00884165
75nucleotide-excision repair, DNA gap filling (GO:0006297)2.98838422
76positive regulation of prostaglandin secretion (GO:0032308)2.98794928
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98609799
78response to interferon-beta (GO:0035456)2.96898160
79kinetochore assembly (GO:0051382)2.96735911
80ribosome biogenesis (GO:0042254)2.95706078
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95180719
82ATP biosynthetic process (GO:0006754)2.95052023
83kynurenine metabolic process (GO:0070189)2.91901831
84hydrogen ion transmembrane transport (GO:1902600)2.91793417
85pseudouridine synthesis (GO:0001522)2.90107189
86aldehyde catabolic process (GO:0046185)2.88957214
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88203640
88respiratory chain complex IV assembly (GO:0008535)2.87957853
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80990528
90nonmotile primary cilium assembly (GO:0035058)2.80495963
91transcription-coupled nucleotide-excision repair (GO:0006283)2.80196762
92tRNA processing (GO:0008033)2.77776825
93response to pheromone (GO:0019236)2.76922778
94proton transport (GO:0015992)2.76024952
95indolalkylamine metabolic process (GO:0006586)2.75594940
96oxidative phosphorylation (GO:0006119)2.75488829
97synapsis (GO:0007129)2.74973528
98IMP metabolic process (GO:0046040)2.74347478
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74099705
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73441193
101intracellular protein transmembrane import (GO:0044743)2.72538611
1027-methylguanosine mRNA capping (GO:0006370)2.70566393
103DNA replication-independent nucleosome assembly (GO:0006336)2.69910057
104DNA replication-independent nucleosome organization (GO:0034724)2.69910057
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69259154
106* metallo-sulfur cluster assembly (GO:0031163)2.69175398
107* iron-sulfur cluster assembly (GO:0016226)2.69175398
108epithelial cilium movement (GO:0003351)2.69052286
109hydrogen transport (GO:0006818)2.68665942
110regulation of cilium movement (GO:0003352)2.68099687
111replication fork processing (GO:0031297)2.67542476
112RNA capping (GO:0036260)2.66199019
1137-methylguanosine RNA capping (GO:0009452)2.66199019
114rRNA modification (GO:0000154)2.65356729
115cellular ketone body metabolic process (GO:0046950)2.64314356
116indole-containing compound catabolic process (GO:0042436)2.63993858
117indolalkylamine catabolic process (GO:0046218)2.63993858
118tryptophan catabolic process (GO:0006569)2.63993858
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63670517
120regulation of mesoderm development (GO:2000380)2.63513154
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63071652
122base-excision repair, AP site formation (GO:0006285)2.62637701
123termination of RNA polymerase I transcription (GO:0006363)2.61291948
124DNA replication checkpoint (GO:0000076)2.61271273
125cytidine deamination (GO:0009972)2.61103759
126cytidine metabolic process (GO:0046087)2.61103759
127cytidine catabolic process (GO:0006216)2.61103759
128ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60732999
129negative regulation of ligase activity (GO:0051352)2.60500685
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60500685
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60433447
132mannosylation (GO:0097502)2.60325861
133anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60045447
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60028342
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59671978
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59671978
137epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59015749
138retinal cone cell development (GO:0046549)2.58912657
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58718647
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58718647
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58718647
142histone mRNA metabolic process (GO:0008334)2.58529895
143attachment of spindle microtubules to kinetochore (GO:0008608)2.55990592
144adult feeding behavior (GO:0008343)2.55645798
145pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55480422
146IMP biosynthetic process (GO:0006188)2.54949370
147UTP biosynthetic process (GO:0006228)2.52760225
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.52450816
149telomere organization (GO:0032200)2.52357963
150telomere maintenance (GO:0000723)2.51730141
151ubiquinone biosynthetic process (GO:0006744)2.51678103
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50958727
153transcription elongation from RNA polymerase I promoter (GO:0006362)2.50405763
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49791399
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.49134981
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.49134981
157spliceosomal snRNP assembly (GO:0000387)2.48797014
158mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48552848
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.48552848
160NADH dehydrogenase complex assembly (GO:0010257)2.48552848
161antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.48411316
162protein prenylation (GO:0018342)2.47554781
163prenylation (GO:0097354)2.47554781
164regulation of cellular amino acid metabolic process (GO:0006521)2.47282714
165nucleobase biosynthetic process (GO:0046112)2.46624654
166antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.46452320
167antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.46452320
168RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44556397
169GPI anchor metabolic process (GO:0006505)2.44422658
170nucleoside triphosphate biosynthetic process (GO:0009142)2.43626605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03490981
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.77354920
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65293181
4ZNF274_21170338_ChIP-Seq_K562_Hela3.32170750
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19111334
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.15559161
7VDR_22108803_ChIP-Seq_LS180_Human3.12841184
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.10767443
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99553050
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91628834
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84963182
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82019915
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.72804001
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65699461
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63092459
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60105052
17* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56404259
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53220443
19* VDR_23849224_ChIP-Seq_CD4+_Human2.47531653
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40279867
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39111475
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.33284364
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.26394232
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26352499
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24092057
26SCL_19346495_ChIP-Seq_HPC-7_Human2.20454765
27FOXP3_21729870_ChIP-Seq_TREG_Human2.20320564
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.19281317
29HOXB4_20404135_ChIP-ChIP_EML_Mouse2.18108935
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16700175
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16378165
32IGF1R_20145208_ChIP-Seq_DFB_Human2.14628787
33XRN2_22483619_ChIP-Seq_HELA_Human2.11864918
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02343721
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.98814201
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.97279479
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96442595
38EZH2_22144423_ChIP-Seq_EOC_Human1.94691092
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94372578
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.93598054
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91821937
42EWS_26573619_Chip-Seq_HEK293_Human1.91780632
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91761922
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.91383870
45DCP1A_22483619_ChIP-Seq_HELA_Human1.90757020
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88080906
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88027113
48ELK1_19687146_ChIP-ChIP_HELA_Human1.86331181
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84226721
50GABP_19822575_ChIP-Seq_HepG2_Human1.75111067
51TTF2_22483619_ChIP-Seq_HELA_Human1.74711424
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73899968
53SPI1_23547873_ChIP-Seq_NB4_Human1.72590130
54GBX2_23144817_ChIP-Seq_PC3_Human1.69875676
55TP53_22573176_ChIP-Seq_HFKS_Human1.69100473
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68747897
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64961840
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59541467
59IRF1_19129219_ChIP-ChIP_H3396_Human1.58935289
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58544103
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58225381
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58221305
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58184102
64FUS_26573619_Chip-Seq_HEK293_Human1.57534315
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56901710
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55401228
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52792447
68P300_19829295_ChIP-Seq_ESCs_Human1.51984903
69CIITA_25753668_ChIP-Seq_RAJI_Human1.50771999
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49540049
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49388808
72ER_23166858_ChIP-Seq_MCF-7_Human1.42879664
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42564507
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42224149
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41934851
76GATA1_22025678_ChIP-Seq_K562_Human1.41605426
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.40979113
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.40741391
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40370974
80* FOXA1_25329375_ChIP-Seq_VCAP_Human1.39319973
81* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39319973
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.39116886
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38716224
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38494014
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38034401
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35623638
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.34496232
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33459528
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32876963
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31213733
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30697247
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30361785
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30042509
94SOX2_19829295_ChIP-Seq_ESCs_Human1.29962652
95NANOG_19829295_ChIP-Seq_ESCs_Human1.29962652
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29824279
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29117802
98VDR_21846776_ChIP-Seq_THP-1_Human1.28962790
99MYC_22102868_ChIP-Seq_BL_Human1.28795340
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28255857
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28210278
102* AR_20517297_ChIP-Seq_VCAP_Human1.26047799
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25023761
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23874278
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21882542
106* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21279429
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20682735
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19142274
109TAF15_26573619_Chip-Seq_HEK293_Human1.18295936
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.17985516
111NCOR_22424771_ChIP-Seq_293T_Human1.16951484
112GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15910935
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12769878
114BCAT_22108803_ChIP-Seq_LS180_Human1.12735451
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12693742
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.12675238
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11905417
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11901141
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11090880
120HOXB7_26014856_ChIP-Seq_BT474_Human1.09896625
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09740581
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09107608
123RUNX1_22412390_ChIP-Seq_EML_Mouse1.09084813
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09066774
125MYB_26560356_Chip-Seq_TH2_Human1.08259504
126AR_21909140_ChIP-Seq_LNCAP_Human1.08183882
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.06683502
128* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06623137
129AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06286544
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05025390
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04310079
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03325380
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03251357
134CBP_20019798_ChIP-Seq_JUKART_Human1.03251357
135ELK1_22589737_ChIP-Seq_MCF10A_Human1.02085929
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00960583
137KDM5A_27292631_Chip-Seq_BREAST_Human1.00464892
138NANOG_20526341_ChIP-Seq_ESCs_Human0.99931172
139MYC_18940864_ChIP-ChIP_HL60_Human0.99544796
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99439587
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99190864
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99170530
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.99045819
144TCF4_22108803_ChIP-Seq_LS180_Human0.98476540
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97681415
146MYC_19829295_ChIP-Seq_ESCs_Human0.97503380
147ERA_21632823_ChIP-Seq_H3396_Human0.96723507
148ERG_20517297_ChIP-Seq_VCAP_Human0.95656009
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.95542599
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94086853
151MYB_26560356_Chip-Seq_TH1_Human0.93664081
152RNF2_27304074_Chip-Seq_NSC_Mouse0.93556269
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93441905
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92275978
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91975875
156SALL1_21062744_ChIP-ChIP_HESCs_Human0.91712542
157KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91601937
158AR_25329375_ChIP-Seq_VCAP_Human0.91506061
159TAF2_19829295_ChIP-Seq_ESCs_Human0.91335810
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91169097
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90511813
162* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90280666
163VDR_24763502_ChIP-Seq_THP-1_Human0.90174188
164CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90135221
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89256762
166MAF_26560356_Chip-Seq_TH1_Human0.87879212
167EGR1_19374776_ChIP-ChIP_THP-1_Human0.87219330
168TFEB_21752829_ChIP-Seq_HELA_Human0.86811875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.74606651
2MP0002396_abnormal_hematopoietic_system3.56246389
3MP0010094_abnormal_chromosome_stability3.15977056
4MP0004957_abnormal_blastocyst_morpholog2.99699745
5MP0003195_calcinosis2.95587589
6MP0002102_abnormal_ear_morphology2.94378521
7MP0001835_abnormal_antigen_presentation2.91230509
8MP0002938_white_spotting2.78444985
9MP0003077_abnormal_cell_cycle2.61970834
10MP0004808_abnormal_hematopoietic_stem2.59374822
11MP0003111_abnormal_nucleus_morphology2.56159626
12MP0001545_abnormal_hematopoietic_system2.47201917
13MP0005397_hematopoietic_system_phenotyp2.47201917
14MP0002837_dystrophic_cardiac_calcinosis2.45314129
15MP0008875_abnormal_xenobiotic_pharmacok2.41744933
16MP0005671_abnormal_response_to2.35527331
17MP0008058_abnormal_DNA_repair2.34083339
18MP0006072_abnormal_retinal_apoptosis2.33754284
19MP0009379_abnormal_foot_pigmentation2.30526612
20MP0003136_yellow_coat_color2.25612769
21MP0008007_abnormal_cellular_replicative2.19996961
22MP0005551_abnormal_eye_electrophysiolog2.17487809
23MP0000490_abnormal_crypts_of2.16640926
24MP0008057_abnormal_DNA_replication2.10286352
25MP0002163_abnormal_gland_morphology2.08369186
26MP0002398_abnormal_bone_marrow2.08363500
27MP0005075_abnormal_melanosome_morpholog2.08155445
28MP0003763_abnormal_thymus_physiology2.07413438
29MP0005464_abnormal_platelet_physiology1.99727547
30MP0003011_delayed_dark_adaptation1.99238878
31MP0002166_altered_tumor_susceptibility1.98737101
32MP0009785_altered_susceptibility_to1.96880903
33MP0003646_muscle_fatigue1.96086750
34MP0004147_increased_porphyrin_level1.95287204
35MP0000685_abnormal_immune_system1.91960468
36MP0001485_abnormal_pinna_reflex1.88985367
37MP0000689_abnormal_spleen_morphology1.86609987
38MP0009333_abnormal_splenocyte_physiolog1.86308605
39MP0000465_gastrointestinal_hemorrhage1.86147728
40MP0005174_abnormal_tail_pigmentation1.82356552
41MP0005645_abnormal_hypothalamus_physiol1.80092656
42MP0002722_abnormal_immune_system1.78440914
43MP0000569_abnormal_digit_pigmentation1.76667513
44MP0001800_abnormal_humoral_immune1.76662892
45MP0001529_abnormal_vocalization1.76152320
46MP0002148_abnormal_hypersensitivity_rea1.74722299
47MP0003283_abnormal_digestive_organ1.74541285
48MP0001873_stomach_inflammation1.73826640
49MP0002277_abnormal_respiratory_mucosa1.72744421
50MP0005025_abnormal_response_to1.72183138
51MP0003787_abnormal_imprinting1.72015700
52MP0003656_abnormal_erythrocyte_physiolo1.71848842
53MP0002420_abnormal_adaptive_immunity1.71026898
54MP0001293_anophthalmia1.70140386
55MP0003786_premature_aging1.69002600
56MP0001819_abnormal_immune_cell1.68790498
57MP0003186_abnormal_redox_activity1.66296758
58MP0002452_abnormal_antigen_presenting1.65957467
59MP0002006_tumorigenesis1.65841151
60MP0004142_abnormal_muscle_tone1.64778404
61MP0000716_abnormal_immune_system1.64064076
62MP0002429_abnormal_blood_cell1.63857279
63MP0005646_abnormal_pituitary_gland1.63778942
64MP0001853_heart_inflammation1.62377186
65MP0002095_abnormal_skin_pigmentation1.61594550
66MP0002736_abnormal_nociception_after1.61202551
67MP0002723_abnormal_immune_serum1.60547196
68MP0001986_abnormal_taste_sensitivity1.58865608
69MP0002138_abnormal_hepatobiliary_system1.58560579
70MP0002132_abnormal_respiratory_system1.58514571
71MP0002876_abnormal_thyroid_physiology1.56945006
72MP0006054_spinal_hemorrhage1.55980534
73MP0005253_abnormal_eye_physiology1.54885691
74MP0006036_abnormal_mitochondrial_physio1.53574500
75MP0003724_increased_susceptibility_to1.52215233
76MP0005000_abnormal_immune_tolerance1.51216722
77MP0010155_abnormal_intestine_physiology1.51011107
78MP0004133_heterotaxia1.48821332
79MP0001968_abnormal_touch/_nociception1.48413859
80MP0006292_abnormal_olfactory_placode1.48043800
81MP0004885_abnormal_endolymph1.47773528
82MP0002019_abnormal_tumor_incidence1.46341424
83MP0005389_reproductive_system_phenotype1.46204957
84MP0008789_abnormal_olfactory_epithelium1.44822298
85MP0002234_abnormal_pharynx_morphology1.44597823
86MP0000703_abnormal_thymus_morphology1.41984279
87MP0002653_abnormal_ependyma_morphology1.41686860
88MP0000631_abnormal_neuroendocrine_gland1.39930443
89MP0002009_preneoplasia1.38790313
90MP0002160_abnormal_reproductive_system1.38172467
91MP0002405_respiratory_system_inflammati1.36679522
92MP0005379_endocrine/exocrine_gland_phen1.36415856
93MP0002419_abnormal_innate_immunity1.34060825
94MP0008872_abnormal_physiological_respon1.33922900
95MP0006276_abnormal_autonomic_nervous1.32264345
96MP0008877_abnormal_DNA_methylation1.30020143
97MP0003866_abnormal_defecation1.29017938
98MP0008932_abnormal_embryonic_tissue1.28466751
99MP0005387_immune_system_phenotype1.26332065
100MP0001790_abnormal_immune_system1.26332065
101MP0003943_abnormal_hepatobiliary_system1.24421758
102MP0003718_maternal_effect1.24280901
103MP0000313_abnormal_cell_death1.24197996
104MP0000566_synostosis1.23971847
105MP0003436_decreased_susceptibility_to1.19409460
106MP0003878_abnormal_ear_physiology1.15476763
107MP0005377_hearing/vestibular/ear_phenot1.15476763
108MP0004742_abnormal_vestibular_system1.13915286
109MP0005195_abnormal_posterior_eye1.12214095
110MP0001919_abnormal_reproductive_system1.11436937
111MP0005310_abnormal_salivary_gland1.11343350
112MP0001905_abnormal_dopamine_level1.11085701
113MP0002272_abnormal_nervous_system1.09754921
114MP0009697_abnormal_copulation1.08573393
115MP0002928_abnormal_bile_duct1.08462331
116MP0002638_abnormal_pupillary_reflex1.07510153
117MP0001324_abnormal_eye_pigmentation1.07437403
118MP0009046_muscle_twitch1.07026745
119MP0009745_abnormal_behavioral_response1.06817070
120MP0000343_altered_response_to1.06053131
121MP0001984_abnormal_olfaction1.04842421
122MP0001845_abnormal_inflammatory_respons1.03883068
123MP0003567_abnormal_fetal_cardiomyocyte1.03863284
124MP0000350_abnormal_cell_proliferation1.03420495
125MP0003315_abnormal_perineum_morphology1.02837439
126MP0000427_abnormal_hair_cycle1.02213091
127MP0000015_abnormal_ear_pigmentation1.00516754
128MP0000026_abnormal_inner_ear0.99817585
129MP0010386_abnormal_urinary_bladder0.97796172
130MP0010307_abnormal_tumor_latency0.96293039
131MP0002254_reproductive_system_inflammat0.94973792
132MP0006082_CNS_inflammation0.94707302
133MP0000049_abnormal_middle_ear0.92651422
134MP0000858_altered_metastatic_potential0.91674891
135MP0010030_abnormal_orbit_morphology0.91118894
136MP0008995_early_reproductive_senescence0.89843991
137MP0000372_irregular_coat_pigmentation0.89117195
138MP0001501_abnormal_sleep_pattern0.88606383
139MP0005332_abnormal_amino_acid0.88390857
140MP0003938_abnormal_ear_development0.87853439
141MP0003121_genomic_imprinting0.87380913
142MP0008469_abnormal_protein_level0.86580133
143MP0004019_abnormal_vitamin_homeostasis0.86234767
144MP0004510_myositis0.85302384
145MP0002751_abnormal_autonomic_nervous0.84439834
146MP0001730_embryonic_growth_arrest0.84263547
147MP0001963_abnormal_hearing_physiology0.84005014
148MP0003806_abnormal_nucleotide_metabolis0.83951805
149MP0005410_abnormal_fertilization0.83598185
150MP0002752_abnormal_somatic_nervous0.83487467
151MP0002210_abnormal_sex_determination0.83144206
152MP0005499_abnormal_olfactory_system0.81681651
153MP0005394_taste/olfaction_phenotype0.81681651
154MP0003880_abnormal_central_pattern0.80841041
155MP0001119_abnormal_female_reproductive0.79744836
156MP0000647_abnormal_sebaceous_gland0.79015326
157MP0002557_abnormal_social/conspecific_i0.77979371
158MP0001486_abnormal_startle_reflex0.76601658
159MP0005391_vision/eye_phenotype0.76501549
160MP0003252_abnormal_bile_duct0.76313945
161MP0005636_abnormal_mineral_homeostasis0.75920067
162MP0001929_abnormal_gametogenesis0.73150109
163MP0005171_absent_coat_pigmentation0.73121604
164MP0003828_pulmonary_edema0.72591457
165MP0009278_abnormal_bone_marrow0.72153263
166MP0001697_abnormal_embryo_size0.71587921
167MP0001145_abnormal_male_reproductive0.71482861
168MP0006035_abnormal_mitochondrial_morpho0.70709259
169MP0001764_abnormal_homeostasis0.70307057
170MP0002080_prenatal_lethality0.69726959
171MP0010352_gastrointestinal_tract_polyps0.68240982
172MP0000653_abnormal_sex_gland0.66622061
173MP0000477_abnormal_intestine_morphology0.64224220
174MP0001663_abnormal_digestive_system0.62457152
175MP0002075_abnormal_coat/hair_pigmentati0.55206493
176MP0005084_abnormal_gallbladder_morpholo0.53229292

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.30273764
2Abnormal number of erythroid precursors (HP:0012131)6.21164153
3Reticulocytopenia (HP:0001896)5.15565600
4Aplastic anemia (HP:0001915)4.45150933
5Thrombocytosis (HP:0001894)4.27925013
6Petechiae (HP:0000967)3.95022613
7Pallor (HP:0000980)3.88564259
8Molar tooth sign on MRI (HP:0002419)3.82127534
9Abnormality of midbrain morphology (HP:0002418)3.82127534
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.74668780
11IgM deficiency (HP:0002850)3.63374132
12Macrocytic anemia (HP:0001972)3.57190019
13Pancreatic fibrosis (HP:0100732)3.52956494
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.51966253
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.51966253
16True hermaphroditism (HP:0010459)3.42571564
17Congenital stationary night blindness (HP:0007642)3.37958112
18Hepatocellular necrosis (HP:0001404)3.35790905
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.27592029
20Birth length less than 3rd percentile (HP:0003561)3.25273447
21Type II lissencephaly (HP:0007260)3.23260193
223-Methylglutaconic aciduria (HP:0003535)3.15595832
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.08041650
24Type I transferrin isoform profile (HP:0003642)3.07969370
25Nephronophthisis (HP:0000090)3.07440229
26Hepatic necrosis (HP:0002605)3.04851427
27Mitochondrial inheritance (HP:0001427)3.00017619
28Increased hepatocellular lipid droplets (HP:0006565)2.99693314
29Prolonged bleeding time (HP:0003010)2.95383665
30Exertional dyspnea (HP:0002875)2.94454244
31Reduced antithrombin III activity (HP:0001976)2.87467284
32Medial flaring of the eyebrow (HP:0010747)2.85681034
33Increased intramyocellular lipid droplets (HP:0012240)2.85458667
34Muscle fiber atrophy (HP:0100295)2.84040205
35Type 2 muscle fiber atrophy (HP:0003554)2.81885058
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78541448
37Abnormal rod and cone electroretinograms (HP:0008323)2.78032702
38Myelodysplasia (HP:0002863)2.69951487
39Increased CSF lactate (HP:0002490)2.68862824
40Chronic otitis media (HP:0000389)2.66149327
41Lipid accumulation in hepatocytes (HP:0006561)2.65351647
42Cerebral edema (HP:0002181)2.63791216
43Hypoplasia of the pons (HP:0012110)2.61417038
44Abolished electroretinogram (ERG) (HP:0000550)2.59833638
45Abnormality of the pons (HP:0007361)2.57556276
46Pancytopenia (HP:0001876)2.55341186
47Colon cancer (HP:0003003)2.53256490
48Increased serum lactate (HP:0002151)2.53223679
49Abnormal mitochondria in muscle tissue (HP:0008316)2.50897098
50Oral leukoplakia (HP:0002745)2.48957362
51Acute necrotizing encephalopathy (HP:0006965)2.48018771
52Respiratory difficulties (HP:0002880)2.47411375
53Increased muscle lipid content (HP:0009058)2.46000546
54Methylmalonic acidemia (HP:0002912)2.45227931
55Hypothermia (HP:0002045)2.44503256
56Polydipsia (HP:0001959)2.44327869
57Abnormal drinking behavior (HP:0030082)2.44327869
58Sclerocornea (HP:0000647)2.43764639
59Abnormality of T cell physiology (HP:0011840)2.43035810
60Abnormality of the renal medulla (HP:0100957)2.42976500
61IgG deficiency (HP:0004315)2.42540102
62Chromsome breakage (HP:0040012)2.42186578
63Optic disc pallor (HP:0000543)2.38248331
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37640725
65Microretrognathia (HP:0000308)2.37415225
66Renal Fanconi syndrome (HP:0001994)2.36009807
67Hyperglycinemia (HP:0002154)2.34983191
68Abnormal platelet function (HP:0011869)2.34876091
69Impaired platelet aggregation (HP:0003540)2.34876091
70Recurrent abscess formation (HP:0002722)2.33565813
71Myositis (HP:0100614)2.33272502
72Retinal dysplasia (HP:0007973)2.33252990
73Breast hypoplasia (HP:0003187)2.33151073
74Abnormal protein glycosylation (HP:0012346)2.32297789
75Abnormal glycosylation (HP:0012345)2.32297789
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32297789
77Abnormal protein N-linked glycosylation (HP:0012347)2.32297789
7811 pairs of ribs (HP:0000878)2.32068823
79Nasal polyposis (HP:0100582)2.30291355
80Cerebellar dysplasia (HP:0007033)2.27158536
81Panhypogammaglobulinemia (HP:0003139)2.26092059
82Attenuation of retinal blood vessels (HP:0007843)2.24513885
83Elevated erythrocyte sedimentation rate (HP:0003565)2.23366334
84Abnormality of the renal cortex (HP:0011035)2.23112966
85Lethargy (HP:0001254)2.22040318
86Abnormality of the preputium (HP:0100587)2.21759032
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21584810
88Abnormality of alanine metabolism (HP:0010916)2.21584810
89Hyperalaninemia (HP:0003348)2.21584810
90Concave nail (HP:0001598)2.21346762
91Anencephaly (HP:0002323)2.17939846
92Abnormality of the nasal mucosa (HP:0000433)2.17490231
93Pendular nystagmus (HP:0012043)2.17034034
94Congenital hepatic fibrosis (HP:0002612)2.16392815
95Epistaxis (HP:0000421)2.15831128
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.15441441
97Lactic acidosis (HP:0003128)2.13894193
98Methylmalonic aciduria (HP:0012120)2.12244835
99Recurrent bronchitis (HP:0002837)2.12192867
100Abnormality of chromosome stability (HP:0003220)2.11613624
101Bile duct proliferation (HP:0001408)2.10727734
102Abnormal biliary tract physiology (HP:0012439)2.10727734
103Congenital, generalized hypertrichosis (HP:0004540)2.09821593
104Lymphoma (HP:0002665)2.09736877
105Microcytic anemia (HP:0001935)2.08653549
106Congenital primary aphakia (HP:0007707)2.07694919
107Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07676846
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.06564896
109Bone marrow hypocellularity (HP:0005528)2.06438775
110Cystic liver disease (HP:0006706)2.06362813
111Pustule (HP:0200039)2.04573608
112Decreased central vision (HP:0007663)2.02714622
113Gait imbalance (HP:0002141)2.02652020
114Recurrent bacterial skin infections (HP:0005406)1.99446853
115Abnormality of reticulocytes (HP:0004312)1.99072162
116Septo-optic dysplasia (HP:0100842)1.98785777
117Abnormality of the columella (HP:0009929)1.98750687
118Abnormality of the labia minora (HP:0012880)1.98274668
119Exercise intolerance (HP:0003546)1.98052253
120Anophthalmia (HP:0000528)1.97737221
121Abnormality of T cells (HP:0002843)1.95856476
122Postaxial foot polydactyly (HP:0001830)1.95680391
123Recurrent viral infections (HP:0004429)1.95368189
124Acute myeloid leukemia (HP:0004808)1.95172446
125Constricted visual fields (HP:0001133)1.95076807
126Respiratory failure (HP:0002878)1.94477551
127Tubular atrophy (HP:0000092)1.94334800
128Neutropenia (HP:0001875)1.94164760
129Nephrogenic diabetes insipidus (HP:0009806)1.92142589
130Hypomagnesemia (HP:0002917)1.92097171
131Pancreatic cysts (HP:0001737)1.90984057
132Acute encephalopathy (HP:0006846)1.90600728
133Male pseudohermaphroditism (HP:0000037)1.90423750
134Polyuria (HP:0000103)1.90359474
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89680242
136Absent thumb (HP:0009777)1.89423814
137Abnormality of urine glucose concentration (HP:0011016)1.89364596
138Glycosuria (HP:0003076)1.89364596
139Chronic hepatic failure (HP:0100626)1.88768227
140Clubbing of toes (HP:0100760)1.88550113
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.88539067
142Optic nerve hypoplasia (HP:0000609)1.88379639
143Progressive macrocephaly (HP:0004481)1.87175764
144Patellar aplasia (HP:0006443)1.84327323
145Recurrent fungal infections (HP:0002841)1.83658401
146Increased corneal curvature (HP:0100692)1.82344060
147Keratoconus (HP:0000563)1.82344060
148Amaurosis fugax (HP:0100576)1.81831229
149Abnormality of renal resorption (HP:0011038)1.81665856
150Meckel diverticulum (HP:0002245)1.81465183
151Asplenia (HP:0001746)1.80734402
152Rib fusion (HP:0000902)1.80510666
153Severe muscular hypotonia (HP:0006829)1.79819746
154Aplasia/hypoplasia of the uterus (HP:0008684)1.78965740
155B lymphocytopenia (HP:0010976)1.78873813
156Abnormality of B cell number (HP:0010975)1.78873813
157Optic nerve coloboma (HP:0000588)1.78548683
158Acute lymphatic leukemia (HP:0006721)1.78478494
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77967635
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.77930840
161Purpura (HP:0000979)1.76462342
162Genital tract atresia (HP:0001827)1.75480010
163Abnormality of serum amino acid levels (HP:0003112)1.74654448
164Abnormality of the anterior horn cell (HP:0006802)1.73977486
165Degeneration of anterior horn cells (HP:0002398)1.73977486
166Albinism (HP:0001022)1.73480709
167Abnormality of the ileum (HP:0001549)1.73182254
168Microvesicular hepatic steatosis (HP:0001414)1.72932487
169Poikiloderma (HP:0001029)1.71840261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.90682638
2EIF2AK13.33604112
3FRK3.28947703
4STK163.21294926
5WEE12.98045725
6MAP4K22.93801066
7VRK22.82313296
8BUB12.65676099
9MAP4K12.58541765
10PIM22.54157534
11NUAK12.41596557
12WNK32.39094646
13WNK42.33162110
14KIT2.25687065
15GRK12.25539077
16MUSK2.19973391
17ACVR1B2.17982793
18TEC2.01207569
19BMPR1B1.99074430
20BRSK21.96981848
21CDC71.87125508
22MAP3K121.86933206
23VRK11.86408222
24MKNK11.84863940
25TXK1.77594419
26CDK81.66412171
27EIF2AK31.65299590
28PLK41.64554558
29TGFBR11.63676105
30BTK1.58730925
31RPS6KB21.49294437
32STK391.46021678
33SRPK11.44195830
34INSRR1.43674718
35PIM11.40108760
36OXSR11.33190151
37FLT31.31682908
38IRAK41.25988313
39MKNK21.23785047
40JAK31.23783399
41CCNB11.23438037
42DYRK21.23376259
43KDR1.22931668
44NEK11.22172001
45ZAP701.20685188
46DYRK31.19242730
47NEK21.19098160
48IKBKE1.16250001
49CDK71.13734757
50CASK1.09399753
51AURKB1.08743243
52TGFBR21.08450629
53TRIM281.08155330
54IKBKB1.07291448
55PLK31.05459694
56PLK11.04756062
57SYK1.03959408
58ZAK1.03754319
59STK41.01787135
60MAP2K31.01706859
61TESK21.01669921
62RPS6KA50.99982212
63MAPKAPK30.99904501
64BRSK10.97261684
65PASK0.93021451
66ATR0.92449030
67MAPK130.91392219
68CSF1R0.90792680
69CDK190.90727849
70MAPK150.89612675
71MYLK0.88938038
72CSNK1G10.86742854
73MARK30.86682461
74MAP3K60.82854850
75LRRK20.82811695
76CSNK1G30.82621276
77MAPKAPK50.81891139
78ADRBK10.80488539
79TSSK60.80173986
80TLK10.77300880
81TIE10.77258986
82TTK0.77087655
83CSNK1G20.76402421
84LIMK10.76339900
85RAF10.75636877
86TBK10.74757637
87STK100.74499241
88ADRBK20.74168803
89MATK0.74116327
90RPS6KA40.74029045
91STK38L0.73723999
92LYN0.73007629
93EEF2K0.72552816
94MAP3K40.72353505
95CDK40.71987214
96CHEK20.70492501
97TAOK30.69672563
98NLK0.68793870
99PRKCG0.68363599
100PINK10.68270395
101MST40.66790276
102EIF2AK20.66239163
103TYK20.65790750
104STK240.65103055
105PLK20.63606625
106PAK30.63402221
107ARAF0.62227267
108CHUK0.62046681
109NEK90.61289643
110PRKCE0.60791542
111ILK0.60714330
112PRKCI0.60678392
113BRD40.59788995
114MAP2K70.59220996
115LCK0.59032762
116MAP3K110.57211592
117BCKDK0.56304388
118PRKCQ0.55646628
119CSNK2A10.55383207
120PAK40.53450418
121AURKA0.51322051
122CSNK1A1L0.51309197
123RPS6KA60.50666725
124IRAK30.50585814
125ABL20.50328290
126CAMKK20.49280039
127PHKG20.48311394
128PHKG10.48311394
129MAP3K80.48280709
130PDK20.47799427
131CSNK2A20.47677733
132NME10.46376932
133BLK0.45929295
134TNIK0.45563427
135GRK70.45300817
136PRKG20.43848726
137NTRK20.43636400
138DAPK20.43240664
139STK30.43095737
140MAP2K60.42988616
141PRKACA0.42829798
142BRAF0.42686455
143PRKD30.41455746
144CSNK1A10.38766851
145PIK3CA0.37120049
146ITK0.34410971
147MAP2K20.34270203
148PRKCA0.33868206

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.36983088
2DNA replication_Homo sapiens_hsa030304.54270059
3Mismatch repair_Homo sapiens_hsa034303.65154582
4RNA polymerase_Homo sapiens_hsa030203.51429556
5Proteasome_Homo sapiens_hsa030503.14374792
6Homologous recombination_Homo sapiens_hsa034402.96126010
7Base excision repair_Homo sapiens_hsa034102.72340073
8Pyrimidine metabolism_Homo sapiens_hsa002402.57491355
9Spliceosome_Homo sapiens_hsa030402.54313814
10Nucleotide excision repair_Homo sapiens_hsa034202.47845231
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47680738
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06451266
13Parkinsons disease_Homo sapiens_hsa050121.92627976
14Cell cycle_Homo sapiens_hsa041101.89828201
15RNA degradation_Homo sapiens_hsa030181.88107847
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87356653
17RNA transport_Homo sapiens_hsa030131.83866677
18Basal transcription factors_Homo sapiens_hsa030221.77702010
19Fanconi anemia pathway_Homo sapiens_hsa034601.73006969
20Phototransduction_Homo sapiens_hsa047441.70662725
21Oxidative phosphorylation_Homo sapiens_hsa001901.69613470
22Non-homologous end-joining_Homo sapiens_hsa034501.64356524
23Primary immunodeficiency_Homo sapiens_hsa053401.63962844
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.51580459
25Protein export_Homo sapiens_hsa030601.51317693
26Cardiac muscle contraction_Homo sapiens_hsa042601.50240106
27Purine metabolism_Homo sapiens_hsa002301.50089655
28Propanoate metabolism_Homo sapiens_hsa006401.46278046
29Butanoate metabolism_Homo sapiens_hsa006501.45975448
30Nitrogen metabolism_Homo sapiens_hsa009101.44021475
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41561507
32Huntingtons disease_Homo sapiens_hsa050161.38768263
33Sulfur metabolism_Homo sapiens_hsa009201.37661801
34p53 signaling pathway_Homo sapiens_hsa041151.26110887
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25535872
36Tryptophan metabolism_Homo sapiens_hsa003801.18514066
37Antigen processing and presentation_Homo sapiens_hsa046121.17946369
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17586293
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16950853
40Peroxisome_Homo sapiens_hsa041461.16456999
41Fatty acid elongation_Homo sapiens_hsa000621.14029014
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13300218
43Selenocompound metabolism_Homo sapiens_hsa004501.12637355
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12609204
45Herpes simplex infection_Homo sapiens_hsa051681.12567483
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08873943
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08849577
48Folate biosynthesis_Homo sapiens_hsa007901.08095529
49Hematopoietic cell lineage_Homo sapiens_hsa046401.06572127
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05933898
51Alzheimers disease_Homo sapiens_hsa050101.02653784
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.02174108
53Allograft rejection_Homo sapiens_hsa053301.01880024
54One carbon pool by folate_Homo sapiens_hsa006700.99603845
55Steroid biosynthesis_Homo sapiens_hsa001000.99112128
56beta-Alanine metabolism_Homo sapiens_hsa004100.99088673
57Sulfur relay system_Homo sapiens_hsa041220.98569114
58Systemic lupus erythematosus_Homo sapiens_hsa053220.94504670
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91631825
60Measles_Homo sapiens_hsa051620.91350397
61Epstein-Barr virus infection_Homo sapiens_hsa051690.90579213
62Asthma_Homo sapiens_hsa053100.90367367
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89724093
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88199679
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85358259
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84177339
67Ether lipid metabolism_Homo sapiens_hsa005650.83898205
68Pentose phosphate pathway_Homo sapiens_hsa000300.82591055
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.80393914
70Leishmaniasis_Homo sapiens_hsa051400.80390122
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79667223
72Collecting duct acid secretion_Homo sapiens_hsa049660.79665959
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76838482
74Chemical carcinogenesis_Homo sapiens_hsa052040.76273942
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74310282
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73614436
77Other glycan degradation_Homo sapiens_hsa005110.72181839
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71531830
79N-Glycan biosynthesis_Homo sapiens_hsa005100.68561721
80Legionellosis_Homo sapiens_hsa051340.67248414
81Type I diabetes mellitus_Homo sapiens_hsa049400.66932939
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.65832208
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.64165214
84mRNA surveillance pathway_Homo sapiens_hsa030150.63623555
85Retinol metabolism_Homo sapiens_hsa008300.63016536
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.62556221
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61613982
88Arachidonic acid metabolism_Homo sapiens_hsa005900.61240278
89Rheumatoid arthritis_Homo sapiens_hsa053230.61151283
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.58351566
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57764228
92Regulation of autophagy_Homo sapiens_hsa041400.57548754
93Nicotine addiction_Homo sapiens_hsa050330.56134115
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54836106
95Thyroid cancer_Homo sapiens_hsa052160.54805359
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54273885
97Shigellosis_Homo sapiens_hsa051310.52789771
98Olfactory transduction_Homo sapiens_hsa047400.51776663
99Caffeine metabolism_Homo sapiens_hsa002320.51768944
100Viral carcinogenesis_Homo sapiens_hsa052030.49829875
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49523160
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48773600
103Histidine metabolism_Homo sapiens_hsa003400.47602886
104Apoptosis_Homo sapiens_hsa042100.47421565
105Glutathione metabolism_Homo sapiens_hsa004800.46381868
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.46379327
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45949837
108Autoimmune thyroid disease_Homo sapiens_hsa053200.44997018
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44747886
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44242550
111Metabolic pathways_Homo sapiens_hsa011000.43901180
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43877628
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43113133
114B cell receptor signaling pathway_Homo sapiens_hsa046620.41402035
115Hepatitis B_Homo sapiens_hsa051610.41128664
116HTLV-I infection_Homo sapiens_hsa051660.40276329
117Fatty acid degradation_Homo sapiens_hsa000710.39238527
118Malaria_Homo sapiens_hsa051440.38925782
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38342166
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37673279
121Fructose and mannose metabolism_Homo sapiens_hsa000510.36810621
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36618701
123Fatty acid metabolism_Homo sapiens_hsa012120.35743799
124Influenza A_Homo sapiens_hsa051640.34097217
125Fat digestion and absorption_Homo sapiens_hsa049750.33905669
126Arginine and proline metabolism_Homo sapiens_hsa003300.33269748
127Taste transduction_Homo sapiens_hsa047420.33109616
128Platelet activation_Homo sapiens_hsa046110.33008427
129Linoleic acid metabolism_Homo sapiens_hsa005910.32307977
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.32156619
131Acute myeloid leukemia_Homo sapiens_hsa052210.32108731
132Mineral absorption_Homo sapiens_hsa049780.32067494
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27218524
134Galactose metabolism_Homo sapiens_hsa000520.25682185
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22798437
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22703534
137Vitamin B6 metabolism_Homo sapiens_hsa007500.22684468
138Graft-versus-host disease_Homo sapiens_hsa053320.22578543
139Pertussis_Homo sapiens_hsa051330.21667286
140Oocyte meiosis_Homo sapiens_hsa041140.19095354
141Toxoplasmosis_Homo sapiens_hsa051450.18529091
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18455455
143Alcoholism_Homo sapiens_hsa050340.16867743
144Small cell lung cancer_Homo sapiens_hsa052220.16333469
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.15480664

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