HSBP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)5.93425894
2negative regulation of B cell apoptotic process (GO:0002903)4.30652536
3regulation of rhodopsin mediated signaling pathway (GO:0022400)4.25853370
4negative regulation of immunoglobulin mediated immune response (GO:0002890)4.20956279
5negative regulation of B cell mediated immunity (GO:0002713)4.20956279
6germinal center formation (GO:0002467)4.16051153
7negative regulation of calcium ion transport into cytosol (GO:0010523)4.14604047
8neuronal action potential propagation (GO:0019227)4.13067307
9rhodopsin mediated signaling pathway (GO:0016056)4.10051997
10growth hormone receptor signaling pathway (GO:0060396)4.05632507
11positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.04749460
12negative regulation of viral entry into host cell (GO:0046597)3.98364495
13innate immune response in mucosa (GO:0002227)3.93009826
14regulation of germinal center formation (GO:0002634)3.90658349
15regulation of hypersensitivity (GO:0002883)3.85680381
16GMP metabolic process (GO:0046037)3.85354947
17urate metabolic process (GO:0046415)3.78512905
18regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.74602126
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72430331
20axonemal dynein complex assembly (GO:0070286)3.69585491
21regulation of viral entry into host cell (GO:0046596)3.68413743
22detection of light stimulus involved in sensory perception (GO:0050962)3.64504518
23detection of light stimulus involved in visual perception (GO:0050908)3.64504518
24photoreceptor cell maintenance (GO:0045494)3.62933414
25cilium or flagellum-dependent cell motility (GO:0001539)3.58727317
26S-adenosylmethionine metabolic process (GO:0046500)3.58010358
27negative regulation of Rho protein signal transduction (GO:0035024)3.55594312
28cellular response to growth hormone stimulus (GO:0071378)3.51668981
29preassembly of GPI anchor in ER membrane (GO:0016254)3.48265021
30epithelial cilium movement (GO:0003351)3.44813720
31rRNA transcription (GO:0009303)3.38891395
32cilium movement (GO:0003341)3.38180501
33photoreceptor cell differentiation (GO:0046530)3.36951889
34eye photoreceptor cell differentiation (GO:0001754)3.36951889
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36689303
36neuronal action potential (GO:0019228)3.35155311
37mucosal immune response (GO:0002385)3.34437714
38drug catabolic process (GO:0042737)3.33310968
39acrosome reaction (GO:0007340)3.30710645
40protein heterotetramerization (GO:0051290)3.28063621
41protein localization to cilium (GO:0061512)3.25927710
42regulation of viral release from host cell (GO:1902186)3.25558630
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24235801
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24235801
45cellular response to pH (GO:0071467)3.23275980
46presynaptic membrane assembly (GO:0097105)3.21536931
47oxidative demethylation (GO:0070989)3.20827789
48negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19710421
49negative regulation of T-helper cell differentiation (GO:0045623)3.19710421
50regulation of heat generation (GO:0031650)3.19546828
51phosphate ion transmembrane transport (GO:0035435)3.18975452
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14876434
53short-term memory (GO:0007614)3.14586537
54negative regulation of mast cell activation (GO:0033004)3.14535429
55antibacterial humoral response (GO:0019731)3.13953003
56detection of temperature stimulus involved in sensory perception (GO:0050961)3.13449951
57detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.13449951
58cranial nerve development (GO:0021545)3.13426707
59nucleotide transmembrane transport (GO:1901679)3.13253540
60purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.10807877
61axoneme assembly (GO:0035082)3.10635713
62negative regulation of complement activation (GO:0045916)3.09986431
63organ or tissue specific immune response (GO:0002251)3.07708736
64retinal ganglion cell axon guidance (GO:0031290)3.07338031
65iron ion import (GO:0097286)3.05521783
66dopamine transport (GO:0015872)3.05031592
67peripheral nervous system neuron development (GO:0048935)3.03132859
68L-phenylalanine metabolic process (GO:0006558)3.03116052
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03116052
70calcium-mediated signaling using intracellular calcium source (GO:0035584)3.02767287
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00184373
72regulation of B cell apoptotic process (GO:0002902)3.00087256
73negative regulation of protein activation cascade (GO:2000258)2.99502046
74adenosine metabolic process (GO:0046085)2.99489462
75antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98696716
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97868383
77L-phenylalanine catabolic process (GO:0006559)2.97868383
78glucosamine-containing compound catabolic process (GO:1901072)2.96334934
79tryptophan metabolic process (GO:0006568)2.96183364
80negative regulation of JAK-STAT cascade (GO:0046426)2.94408023
81amino sugar catabolic process (GO:0046348)2.94164139
82antimicrobial humoral response (GO:0019730)2.93676634
83aromatic amino acid family catabolic process (GO:0009074)2.93654039
84response to acidic pH (GO:0010447)2.93415485
85negative regulation of execution phase of apoptosis (GO:1900118)2.93295535
86presynaptic membrane organization (GO:0097090)2.91920506
87intraciliary transport (GO:0042073)2.91704826
88exogenous drug catabolic process (GO:0042738)2.90857524
89retina layer formation (GO:0010842)2.90616517
90indole-containing compound catabolic process (GO:0042436)2.89907955
91indolalkylamine catabolic process (GO:0046218)2.89907955
92tryptophan catabolic process (GO:0006569)2.89907955
93regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.89906936
94negative regulation of cation channel activity (GO:2001258)2.88591940
95drug transmembrane transport (GO:0006855)2.87742509
96omega-hydroxylase P450 pathway (GO:0097267)2.87596147
97long-chain fatty acid biosynthetic process (GO:0042759)2.86340319
98phosphate ion transport (GO:0006817)2.86318609
99cysteine metabolic process (GO:0006534)2.86063207
100entrainment of circadian clock by photoperiod (GO:0043153)2.85879485
101eye photoreceptor cell development (GO:0042462)2.85472156
102neuron fate specification (GO:0048665)2.84759533
103sperm motility (GO:0030317)2.83454346
104multicellular organism reproduction (GO:0032504)2.82815634
105positive regulation of T-helper 1 type immune response (GO:0002827)2.82747765
106photoreceptor cell development (GO:0042461)2.82609053
107positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82023059
108keratinocyte development (GO:0003334)2.80499930
109cellular response to ATP (GO:0071318)2.79534595
110response to redox state (GO:0051775)2.79308902
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78838091
112regulation of timing of cell differentiation (GO:0048505)2.78754512
113cornea development in camera-type eye (GO:0061303)2.78663469
114calcium ion import (GO:0070509)2.77785047
115response to water (GO:0009415)2.77631067
116detection of temperature stimulus (GO:0016048)2.76428307
117cellular ketone body metabolic process (GO:0046950)2.75831529
118response to growth hormone (GO:0060416)2.75716265
119sulfate transmembrane transport (GO:1902358)2.75016514
120L-methionine salvage (GO:0071267)2.74338774
121L-methionine biosynthetic process (GO:0071265)2.74338774
122amino acid salvage (GO:0043102)2.74338774
123negative regulation of heart rate (GO:0010459)2.72100798
124aggressive behavior (GO:0002118)2.71276006
125mannosylation (GO:0097502)2.70201663
126aromatic amino acid family metabolic process (GO:0009072)2.69670554
127retinal cone cell development (GO:0046549)2.69136572
128negative regulation of type 2 immune response (GO:0002829)2.68165228
129calcium ion-dependent exocytosis (GO:0017156)2.67781059
130protein localization to synapse (GO:0035418)2.67213824
131neurofilament cytoskeleton organization (GO:0060052)2.66976263
132detection of mechanical stimulus involved in sensory perception (GO:0050974)2.66941314
133kynurenine metabolic process (GO:0070189)2.66728632
134GPI anchor metabolic process (GO:0006505)2.65976772
135ubiquinone biosynthetic process (GO:0006744)2.65842877
136GTP biosynthetic process (GO:0006183)2.65309382
137membrane depolarization during action potential (GO:0086010)2.65165553
138establishment of skin barrier (GO:0061436)2.64685749
139nonmotile primary cilium assembly (GO:0035058)2.64599260
140respiratory chain complex IV assembly (GO:0008535)2.63809762
141peptidyl-histidine modification (GO:0018202)2.63079316
142GPI anchor biosynthetic process (GO:0006506)2.62271162
143retinal rod cell development (GO:0046548)2.61957512
144water-soluble vitamin biosynthetic process (GO:0042364)2.61016570
145digestion (GO:0007586)2.60615772
146positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.60447323
147short-chain fatty acid metabolic process (GO:0046459)2.60235688
148negative regulation of defense response to virus (GO:0050687)2.59149766
149spermatid nucleus differentiation (GO:0007289)2.57001008
150coenzyme catabolic process (GO:0009109)2.56707425
151cell wall macromolecule catabolic process (GO:0016998)2.56266702
152polyamine metabolic process (GO:0006595)2.54425822
153sulfate transport (GO:0008272)2.54384558
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53306740
155response to pheromone (GO:0019236)2.53274460
156urinary tract smooth muscle contraction (GO:0014848)2.53181617
157positive regulation of prostaglandin secretion (GO:0032308)2.51652216
158chemosensory behavior (GO:0007635)2.49207115
159respiratory electron transport chain (GO:0022904)2.48874484
160negative regulation of homotypic cell-cell adhesion (GO:0034111)2.48100743
161indolalkylamine metabolic process (GO:0006586)2.48003554
162positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.47577062
163regulation of pigment cell differentiation (GO:0050932)2.46354975
164spinal cord motor neuron differentiation (GO:0021522)2.46057066
165somite development (GO:0061053)2.45592206
166positive regulation of steroid hormone secretion (GO:2000833)2.45522801
167neuron cell-cell adhesion (GO:0007158)2.45485556
168regulation of defense response to virus by host (GO:0050691)2.45425901
169electron transport chain (GO:0022900)2.45162809
170quinone biosynthetic process (GO:1901663)2.45085180
171ketone body metabolic process (GO:1902224)2.44293514
172innervation (GO:0060384)2.43651419
173fatty acid elongation (GO:0030497)2.41891588
174desmosome organization (GO:0002934)2.41486615
175left/right pattern formation (GO:0060972)2.40462107
176ceramide catabolic process (GO:0046514)2.39798659
177negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.36291082
178GDP-mannose metabolic process (GO:0019673)2.35956193
179regulation of vesicle fusion (GO:0031338)2.35583805
180protein maturation by protein folding (GO:0022417)2.35525287
181detection of visible light (GO:0009584)2.34944926
182regulation of development, heterochronic (GO:0040034)2.34522062
183action potential (GO:0001508)2.33525121
184regulation of dopamine secretion (GO:0014059)2.31824347
185nucleoside diphosphate phosphorylation (GO:0006165)2.30957860
186regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29771089
187cilium assembly (GO:0042384)2.29430762
188motile cilium assembly (GO:0044458)2.29123561
189guanosine-containing compound biosynthetic process (GO:1901070)2.28087346
190detection of light stimulus (GO:0009583)2.27366251
191sympathetic nervous system development (GO:0048485)2.27348634
192sequestering of actin monomers (GO:0042989)2.27065506
193mechanoreceptor differentiation (GO:0042490)2.26832830
194positive regulation of action potential (GO:0045760)2.26347383
195detection of calcium ion (GO:0005513)2.26305322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.84952410
2EZH2_22144423_ChIP-Seq_EOC_Human3.84413535
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11629484
4GBX2_23144817_ChIP-Seq_PC3_Human3.07922598
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93260818
6VDR_22108803_ChIP-Seq_LS180_Human2.77566119
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.55970098
8TAF15_26573619_Chip-Seq_HEK293_Human2.51229395
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50483408
10STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46409060
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.38223188
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35185197
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32540234
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.25324509
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21938132
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.17123635
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15670609
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12975539
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10562692
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09531087
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07981654
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.07433795
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03006446
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.02774345
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01640835
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99997888
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95892923
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.92235166
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.91835900
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91271620
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89566223
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.89345464
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88901026
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85755286
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85667458
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83300650
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81850370
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81797832
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.79622676
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79327696
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.78673959
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78662316
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77735450
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77538386
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76891516
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76891516
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76198601
48P300_19829295_ChIP-Seq_ESCs_Human1.74899330
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.72563613
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66800163
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.66355322
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66193113
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.64382210
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.64200181
55REST_21632747_ChIP-Seq_MESCs_Mouse1.63431947
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61399264
57E2F1_20622854_ChIP-Seq_HELA_Human1.59954523
58RNF2_27304074_Chip-Seq_NSC_Mouse1.59012916
59VDR_23849224_ChIP-Seq_CD4+_Human1.58157684
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.57590358
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.57347095
62SMAD4_21799915_ChIP-Seq_A2780_Human1.57297982
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56888454
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56810592
65GATA6_25053715_ChIP-Seq_YYC3_Human1.56452616
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55185078
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.55176934
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54449306
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53729437
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53632489
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.50731029
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50423197
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.50022698
74TP53_22573176_ChIP-Seq_HFKS_Human1.48372065
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47909077
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47093578
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45993636
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45885055
79P68_20966046_ChIP-Seq_HELA_Human1.45316113
80CIITA_25753668_ChIP-Seq_RAJI_Human1.45233097
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.44868343
82BCOR_27268052_Chip-Seq_Bcells_Human1.44559087
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.44250578
84GATA4_25053715_ChIP-Seq_YYC3_Human1.42092203
85PHF8_20622854_ChIP-Seq_HELA_Human1.40939385
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39677253
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39656662
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37712190
89P53_22387025_ChIP-Seq_ESCs_Mouse1.37040060
90TFEB_21752829_ChIP-Seq_HELA_Human1.36603633
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36397923
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34907711
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.34628292
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34123851
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33885275
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33308421
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32859381
98ERA_21632823_ChIP-Seq_H3396_Human1.32337666
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32227257
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.31992439
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.31968771
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.31281779
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29796827
104ZNF263_19887448_ChIP-Seq_K562_Human1.29300983
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28803485
106KDM2B_26808549_Chip-Seq_REH_Human1.28442286
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.27971518
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.27569416
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27007925
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.26946209
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.26434524
112BCAT_22108803_ChIP-Seq_LS180_Human1.25605255
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.25036282
114NMYC_18555785_Chip-Seq_ESCs_Mouse1.23803555
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23637275
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22386933
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.20596183
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20166895
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.20114931
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19812585
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18701355
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.18691838
123P300_18555785_Chip-Seq_ESCs_Mouse1.18550322
124RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18523343
125ER_23166858_ChIP-Seq_MCF-7_Human1.18063819
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17463808
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16626828
128AR_20517297_ChIP-Seq_VCAP_Human1.16286579
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15797531
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.14915947
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14887051
132GATA3_26560356_Chip-Seq_TH2_Human1.14538918
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14427297
134ATF3_27146783_Chip-Seq_COLON_Human1.14118483
135TAF2_19829295_ChIP-Seq_ESCs_Human1.14095247
136KLF4_18555785_Chip-Seq_ESCs_Mouse1.13699803
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13197003
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12802222
139STAT1_20625510_ChIP-Seq_HELA_Human1.12627775
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12264094
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11656433
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11574386
143P53_21459846_ChIP-Seq_SAOS-2_Human1.10330437
144AR_25329375_ChIP-Seq_VCAP_Human1.10254432
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10196528
146CTCF_20526341_ChIP-Seq_ESCs_Human1.10099435
147GATA3_24758297_ChIP-Seq_MCF-7_Human1.09949080
148REST_18959480_ChIP-ChIP_MESCs_Mouse1.09224134
149SOX2_20726797_ChIP-Seq_SW620_Human1.08527930
150ETS1_22383799_ChIP-Seq_G1ME_Mouse1.08359964
151TP53_18474530_ChIP-ChIP_U2OS_Human1.08321856
152IGF1R_20145208_ChIP-Seq_DFB_Human1.08097836
153BCL6_27268052_Chip-Seq_Bcells_Human1.08060443
154ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07934592
155FOXA1_25552417_ChIP-Seq_VCAP_Human1.07596324
156PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07478155
157SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07421763
158BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.07373317
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06360194
160P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06052556
161RUNX2_22187159_ChIP-Seq_PCA_Human1.05934964
162STAT3_23295773_ChIP-Seq_U87_Human1.05699518
163DCP1A_22483619_ChIP-Seq_HELA_Human1.05565623
164KDM5A_27292631_Chip-Seq_BREAST_Human1.05440460
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05223405
166SALL1_21062744_ChIP-ChIP_HESCs_Human1.04173580
167CTCF_18555785_Chip-Seq_ESCs_Mouse1.03479632
168ZFX_18555785_Chip-Seq_ESCs_Mouse1.03345221
169GABP_19822575_ChIP-Seq_HepG2_Human1.03172665
170SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03114324
171CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02366211
172HTT_18923047_ChIP-ChIP_STHdh_Human1.02126447
173IRF1_19129219_ChIP-ChIP_H3396_Human1.01482452
174PU1_27457419_Chip-Seq_LIVER_Mouse1.01134750
175FUS_26573619_Chip-Seq_HEK293_Human1.00996040
176ARNT_22903824_ChIP-Seq_MCF-7_Human1.00965908
177FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00392789
178FOXA1_25329375_ChIP-Seq_VCAP_Human1.00392789
179SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00359928
180CRX_20693478_ChIP-Seq_RETINA_Mouse1.00339618
181OCT4_20526341_ChIP-Seq_ESCs_Human1.00182720
182KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99523547
183BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99418179
184P300_27268052_Chip-Seq_Bcells_Human0.99014878
185SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98763146
186CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98744275
187CEBPB_22108803_ChIP-Seq_LS180_Human0.97756252
188EST1_17652178_ChIP-ChIP_JURKAT_Human0.97228152
189AHR_22903824_ChIP-Seq_MCF-7_Human0.97153339
190AR_21572438_ChIP-Seq_LNCaP_Human0.97002064
191KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96242978
192FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95664177
193PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95073877
194ZNF274_21170338_ChIP-Seq_K562_Hela0.94993161
195NCOR_22424771_ChIP-Seq_293T_Human0.94763614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.73809017
2MP0008875_abnormal_xenobiotic_pharmacok5.21743709
3MP0010234_abnormal_vibrissa_follicle4.79066304
4MP0001986_abnormal_taste_sensitivity4.27065401
5MP0002735_abnormal_chemical_nociception3.40177004
6MP0005360_urolithiasis3.38012222
7MP0005075_abnormal_melanosome_morpholog3.26627859
8MP0004147_increased_porphyrin_level3.14557848
9MP0004270_analgesia3.07190770
10MP0003136_yellow_coat_color3.00162936
11MP0006072_abnormal_retinal_apoptosis2.78596473
12MP0005551_abnormal_eye_electrophysiolog2.70783197
13MP0001968_abnormal_touch/_nociception2.65826720
14MP0006276_abnormal_autonomic_nervous2.62989775
15MP0010386_abnormal_urinary_bladder2.61867940
16MP0002139_abnormal_hepatobiliary_system2.57635757
17MP0001188_hyperpigmentation2.52410952
18MP0005365_abnormal_bile_salt2.48396605
19MP0002734_abnormal_mechanical_nocicepti2.46192151
20MP0001542_abnormal_bone_strength2.41358248
21MP0003011_delayed_dark_adaptation2.41037560
22MP0004381_abnormal_hair_follicle2.34011060
23MP0002254_reproductive_system_inflammat2.27686145
24MP0005409_darkened_coat_color2.24021255
25MP0003880_abnormal_central_pattern2.19393212
26MP0002638_abnormal_pupillary_reflex2.17265353
27MP0005253_abnormal_eye_physiology2.14725877
28MP0002736_abnormal_nociception_after2.06716954
29MP0009379_abnormal_foot_pigmentation1.97733866
30MP0002166_altered_tumor_susceptibility1.95473678
31MP0001970_abnormal_pain_threshold1.90243396
32MP0002733_abnormal_thermal_nociception1.84893232
33MP0005410_abnormal_fertilization1.84672528
34MP0001984_abnormal_olfaction1.82883955
35MP0004742_abnormal_vestibular_system1.78980407
36MP0005423_abnormal_somatic_nervous1.76559575
37MP0002272_abnormal_nervous_system1.76424454
38MP0005167_abnormal_blood-brain_barrier1.75941753
39MP0006292_abnormal_olfactory_placode1.71723715
40MP0000566_synostosis1.67399016
41MP0002184_abnormal_innervation1.64642343
42MP0005332_abnormal_amino_acid1.62379382
43MP0002751_abnormal_autonomic_nervous1.56083837
44MP0002163_abnormal_gland_morphology1.55852041
45MP0002006_tumorigenesis1.55107566
46MP0003786_premature_aging1.54146928
47MP0010678_abnormal_skin_adnexa1.52238873
48MP0002067_abnormal_sensory_capabilities1.52178230
49MP0005379_endocrine/exocrine_gland_phen1.50572092
50MP0009643_abnormal_urine_homeostasis1.49750825
51MP0009745_abnormal_behavioral_response1.49348379
52MP0005451_abnormal_body_composition1.49315986
53MP0005085_abnormal_gallbladder_physiolo1.48177724
54MP0008872_abnormal_physiological_respon1.47163097
55MP0009046_muscle_twitch1.45822770
56MP0003806_abnormal_nucleotide_metabolis1.42956380
57MP0003252_abnormal_bile_duct1.40666400
58MP0001486_abnormal_startle_reflex1.40184645
59MP0005083_abnormal_biliary_tract1.36621174
60MP0003172_abnormal_lysosome_physiology1.36553723
61MP0005171_absent_coat_pigmentation1.35366417
62MP0005084_abnormal_gallbladder_morpholo1.34173180
63MP0002876_abnormal_thyroid_physiology1.34164962
64MP0002752_abnormal_somatic_nervous1.34029655
65MP0001853_heart_inflammation1.33394505
66MP0002064_seizures1.31285378
67MP0003191_abnormal_cellular_cholesterol1.26981757
68MP0003635_abnormal_synaptic_transmissio1.26580760
69MP0005645_abnormal_hypothalamus_physiol1.26538478
70MP0000026_abnormal_inner_ear1.26224322
71MP0002277_abnormal_respiratory_mucosa1.25973372
72MP0005501_abnormal_skin_physiology1.25359014
73MP0009780_abnormal_chondrocyte_physiolo1.25036539
74MP0000372_irregular_coat_pigmentation1.23590580
75MP0002229_neurodegeneration1.22814338
76MP0001963_abnormal_hearing_physiology1.22379177
77MP0001664_abnormal_digestion1.21498721
78MP0005220_abnormal_exocrine_pancreas1.20952763
79MP0004145_abnormal_muscle_electrophysio1.20073088
80MP0003646_muscle_fatigue1.18340154
81MP0005636_abnormal_mineral_homeostasis1.18112559
82MP0000015_abnormal_ear_pigmentation1.17308457
83MP0002572_abnormal_emotion/affect_behav1.17204510
84MP0001502_abnormal_circadian_rhythm1.16793519
85MP0002693_abnormal_pancreas_physiology1.16660640
86MP0002557_abnormal_social/conspecific_i1.15236157
87MP0004142_abnormal_muscle_tone1.15220549
88MP0000685_abnormal_immune_system1.15206594
89MP0005535_abnormal_body_temperature1.14875618
90MP0001756_abnormal_urination1.13335709
91MP0001765_abnormal_ion_homeostasis1.12159992
92MP0004947_skin_inflammation1.11806509
93MP0003941_abnormal_skin_development1.11571168
94MP0004859_abnormal_synaptic_plasticity1.11410783
95MP0008260_abnormal_autophagy1.11118670
96MP0006036_abnormal_mitochondrial_physio1.10272223
97MP0001835_abnormal_antigen_presentation1.10269919
98MP0000778_abnormal_nervous_system1.09958930
99MP0000609_abnormal_liver_physiology1.09609871
100MP0002882_abnormal_neuron_morphology1.09341793
101MP0008995_early_reproductive_senescence1.08918151
102MP0010329_abnormal_lipoprotein_level1.08801263
103MP0001485_abnormal_pinna_reflex1.08012466
104MP0002102_abnormal_ear_morphology1.07267952
105MP0002938_white_spotting1.07001060
106MP0008789_abnormal_olfactory_epithelium1.06969571
107MP0000631_abnormal_neuroendocrine_gland1.06392360
108MP0008961_abnormal_basal_metabolism1.04858678
109MP0003195_calcinosis1.04233843
110MP0002136_abnormal_kidney_physiology1.02926659
111MP0003879_abnormal_hair_cell1.02522065
112MP0004858_abnormal_nervous_system1.02099692
113MP0005646_abnormal_pituitary_gland1.01512265
114MP0005195_abnormal_posterior_eye1.01124611
115MP0003950_abnormal_plasma_membrane0.99794076
116MP0002837_dystrophic_cardiac_calcinosis0.99793493
117MP0009785_altered_susceptibility_to0.99291076
118MP0010771_integument_phenotype0.99171763
119MP0001944_abnormal_pancreas_morphology0.98998355
120MP0000579_abnormal_nail_morphology0.98728493
121MP0001440_abnormal_grooming_behavior0.98061826
122MP0001216_abnormal_epidermal_layer0.97951932
123MP0001873_stomach_inflammation0.97787073
124MP0000013_abnormal_adipose_tissue0.97179829
125MP0000955_abnormal_spinal_cord0.96052871
126MP0003868_abnormal_feces_composition0.93305468
127MP0005408_hypopigmentation0.91755604
128MP0001346_abnormal_lacrimal_gland0.91125534
129MP0004043_abnormal_pH_regulation0.90635202
130MP0002063_abnormal_learning/memory/cond0.89891797
131MP0002796_impaired_skin_barrier0.89034742
132MP0005248_abnormal_Harderian_gland0.88636423
133MP0001501_abnormal_sleep_pattern0.86515914
134MP0001243_abnormal_dermal_layer0.86141226
135MP0005310_abnormal_salivary_gland0.85414535
136MP0001905_abnormal_dopamine_level0.83418068
137MP0004885_abnormal_endolymph0.83234028
138MP0003698_abnormal_male_reproductive0.82450264
139MP0008057_abnormal_DNA_replication0.81910140
140MP0000003_abnormal_adipose_tissue0.79948198
141MP0001919_abnormal_reproductive_system0.78902528
142MP0005499_abnormal_olfactory_system0.78870246
143MP0005394_taste/olfaction_phenotype0.78870246
144MP0002098_abnormal_vibrissa_morphology0.78270664
145MP0000647_abnormal_sebaceous_gland0.78132078
146MP0002009_preneoplasia0.76962119
147MP0002118_abnormal_lipid_homeostasis0.76719074
148MP0001764_abnormal_homeostasis0.76457747
149MP0003183_abnormal_peptide_metabolism0.75688312
150MP0003315_abnormal_perineum_morphology0.74548367
151MP0002928_abnormal_bile_duct0.74152818
152MP0000427_abnormal_hair_cycle0.71715418
153MP0005391_vision/eye_phenotype0.71083873
154MP0003866_abnormal_defecation0.71065054
155MP0005647_abnormal_sex_gland0.71002805
156MP0003186_abnormal_redox_activity0.68556302
157MP0002132_abnormal_respiratory_system0.68416041
158MP0006054_spinal_hemorrhage0.67652492
159MP0003787_abnormal_imprinting0.65958359
160MP0000377_abnormal_hair_follicle0.65707408
161MP0003724_increased_susceptibility_to0.65559984
162MP0000613_abnormal_salivary_gland0.61129912
163MP0001661_extended_life_span0.60637371
164MP0005376_homeostasis/metabolism_phenot0.59274073
165MP0000383_abnormal_hair_follicle0.56101146
166MP0002089_abnormal_postnatal_growth/wei0.55842676
167MP0000367_abnormal_coat/_hair0.55578850
168MP0002060_abnormal_skin_morphology0.55471924
169MP0002653_abnormal_ependyma_morphology0.54293257
170MP0005389_reproductive_system_phenotype0.52942718
171MP0001727_abnormal_embryo_implantation0.52875120

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.60061152
2Large eyes (HP:0001090)4.98595954
3Congenital stationary night blindness (HP:0007642)4.88126485
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.80576929
5Absent/shortened dynein arms (HP:0200106)4.29997755
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.29997755
7Reduced subcutaneous adipose tissue (HP:0003758)4.27081943
8Absent rod-and cone-mediated responses on ERG (HP:0007688)4.08593498
9Popliteal pterygium (HP:0009756)4.06485394
103-Methylglutaconic aciduria (HP:0003535)3.96937939
11Delayed CNS myelination (HP:0002188)3.94421920
12Abnormal ciliary motility (HP:0012262)3.89901095
13Abnormality of alanine metabolism (HP:0010916)3.89197586
14Hyperalaninemia (HP:0003348)3.89197586
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.89197586
16Abnormal respiratory motile cilium physiology (HP:0012261)3.86451083
17Abnormal rod and cone electroretinograms (HP:0008323)3.82393375
18Attenuation of retinal blood vessels (HP:0007843)3.47176131
19Decreased central vision (HP:0007663)3.38024503
20Abnormal respiratory epithelium morphology (HP:0012253)3.37821604
21Abnormal respiratory motile cilium morphology (HP:0005938)3.37821604
22Bony spicule pigmentary retinopathy (HP:0007737)3.33929378
23Type II lissencephaly (HP:0007260)3.27854327
24Decreased circulating renin level (HP:0003351)3.22152217
25Tubulointerstitial nephritis (HP:0001970)3.19336957
26Abnormality of proline metabolism (HP:0010907)3.13503054
27Hydroxyprolinuria (HP:0003080)3.13503054
28Cerebellar dysplasia (HP:0007033)3.05771323
29Acute necrotizing encephalopathy (HP:0006965)3.05298421
30Ulnar claw (HP:0001178)2.99038252
31Myokymia (HP:0002411)2.96516802
32Parakeratosis (HP:0001036)2.93066812
33Hypothermia (HP:0002045)2.90978929
34Congenital sensorineural hearing impairment (HP:0008527)2.90697054
35Nasal polyposis (HP:0100582)2.87645960
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.86103126
37Azoospermia (HP:0000027)2.82670482
38Medial flaring of the eyebrow (HP:0010747)2.81229414
39Pancreatic cysts (HP:0001737)2.80226121
40Generalized aminoaciduria (HP:0002909)2.78271493
41Optic disc pallor (HP:0000543)2.78011827
42Chronic otitis media (HP:0000389)2.77933573
43Hypomagnesemia (HP:0002917)2.75849805
44Testicular atrophy (HP:0000029)2.73412331
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70277829
46Hypokalemic alkalosis (HP:0001949)2.68264106
47Ketoacidosis (HP:0001993)2.64408093
48Febrile seizures (HP:0002373)2.64070781
49Focal motor seizures (HP:0011153)2.62144276
50Severe visual impairment (HP:0001141)2.60074563
51Abnormality of renin-angiotensin system (HP:0000847)2.59004644
52Hyperglycinemia (HP:0002154)2.58757107
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57852233
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57852233
55Abnormality of renal resorption (HP:0011038)2.57502060
56Progressive macrocephaly (HP:0004481)2.53235788
57Increased corneal curvature (HP:0100692)2.52418603
58Keratoconus (HP:0000563)2.52418603
59Optic nerve hypoplasia (HP:0000609)2.49815962
60Abnormality of the axillary hair (HP:0100134)2.46382848
61Abnormality of secondary sexual hair (HP:0009888)2.46382848
62Rhinitis (HP:0012384)2.46231108
63Abnormality of calcium-phosphate metabolism (HP:0100530)2.45945801
64Abnormality of macular pigmentation (HP:0008002)2.44588563
65Ketosis (HP:0001946)2.44000556
66Abnormality of magnesium homeostasis (HP:0004921)2.42810541
67Erythema (HP:0010783)2.42735176
68Abnormality of the fingertips (HP:0001211)2.42193366
69Osteomalacia (HP:0002749)2.41064484
70Chronic sinusitis (HP:0011109)2.40618583
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.40072563
72Ileus (HP:0002595)2.39485555
73Chronic hepatic failure (HP:0100626)2.39389117
74Hepatocellular necrosis (HP:0001404)2.37982262
75Acute encephalopathy (HP:0006846)2.37324494
76Abnormal mitochondria in muscle tissue (HP:0008316)2.36967186
77Abnormality of the renal medulla (HP:0100957)2.34787354
78Gait imbalance (HP:0002141)2.34681126
79Amelogenesis imperfecta (HP:0000705)2.33151261
80Renal Fanconi syndrome (HP:0001994)2.30480219
81Congenital primary aphakia (HP:0007707)2.29663378
82Dyschromatopsia (HP:0007641)2.29273679
83Aplasia/hypoplasia of the uterus (HP:0008684)2.28201334
84Abnormality of serine family amino acid metabolism (HP:0010894)2.26625072
85Abnormality of glycine metabolism (HP:0010895)2.26625072
86Aplasia/Hypoplasia of the fovea (HP:0008060)2.26281673
87Hypoplasia of the fovea (HP:0007750)2.26281673
88Hepatic necrosis (HP:0002605)2.26146399
89Congenital ichthyosiform erythroderma (HP:0007431)2.24841245
90Metabolic acidosis (HP:0001942)2.24687692
91Abnormality of the nasal mucosa (HP:0000433)2.24541762
92Abnormality of dental color (HP:0011073)2.24504276
93Sex reversal (HP:0012245)2.24235588
94Abnormal sex determination (HP:0012244)2.24235588
95Hyperkalemia (HP:0002153)2.22767536
96Mitochondrial inheritance (HP:0001427)2.20661392
97Alkalosis (HP:0001948)2.20390225
98Polydipsia (HP:0001959)2.18441957
99Abnormal drinking behavior (HP:0030082)2.18441957
100Microretrognathia (HP:0000308)2.17931341
101Sensory axonal neuropathy (HP:0003390)2.17753371
102Nephrogenic diabetes insipidus (HP:0009806)2.16973108
103Macroglossia (HP:0000158)2.15398083
104Genital tract atresia (HP:0001827)2.14680456
105True hermaphroditism (HP:0010459)2.14356391
106Hyperammonemia (HP:0001987)2.13982496
107Conjugated hyperbilirubinemia (HP:0002908)2.12963771
108Atelectasis (HP:0100750)2.12396957
109Nephronophthisis (HP:0000090)2.12344063
110Basal ganglia calcification (HP:0002135)2.12245551
111Hyperactive renin-angiotensin system (HP:0000841)2.11992661
112Retinal dysplasia (HP:0007973)2.11596396
113Abnormality of chloride homeostasis (HP:0011422)2.11548905
114Arthropathy (HP:0003040)2.10537492
115Vaginal atresia (HP:0000148)2.09571663
116Abnormality of vitamin B metabolism (HP:0004340)2.08746885
117Atonic seizures (HP:0010819)2.06070193
118Chronic bronchitis (HP:0004469)2.05999268
119Retinitis pigmentosa (HP:0000510)2.05331131
120Abnormality of the vitamin B12 metabolism (HP:0004341)2.03657085
121Clubbing of toes (HP:0100760)2.03433085
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03241580
123Increased hepatocellular lipid droplets (HP:0006565)2.02799747
124Conical tooth (HP:0000698)2.01353717
125Progressive cerebellar ataxia (HP:0002073)2.00357060
126Hypoplasia of the uterus (HP:0000013)2.00272103
127Severe muscular hypotonia (HP:0006829)1.99200897
128Renal cortical cysts (HP:0000803)1.98910510
129Hyperaldosteronism (HP:0000859)1.98457732
130Unilateral renal agenesis (HP:0000122)1.96732006
131Prolonged partial thromboplastin time (HP:0003645)1.96198042
132Dysautonomia (HP:0002459)1.96171475
133Nasolacrimal duct obstruction (HP:0000579)1.94432620
134Bronchiectasis (HP:0002110)1.92910886
135Upper limb muscle weakness (HP:0003484)1.92006715
136Tubular atrophy (HP:0000092)1.91741017
137Increased muscle lipid content (HP:0009058)1.91610484
138Alopecia of scalp (HP:0002293)1.91263408
139Pancreatic fibrosis (HP:0100732)1.91091636
140Septo-optic dysplasia (HP:0100842)1.90788562
141Submucous cleft hard palate (HP:0000176)1.90782634
142Abnormality of serum amino acid levels (HP:0003112)1.88979209
143Male pseudohermaphroditism (HP:0000037)1.88051309
144Cardiomegaly (HP:0001640)1.87015680
145Abnormality of transition element cation homeostasis (HP:0011030)1.86584323
146Aplasia/Hypoplasia of the lens (HP:0008063)1.85696570
147Abnormality of the lacrimal duct (HP:0011481)1.84495696
148Hyperglycinuria (HP:0003108)1.83266871
149Photophobia (HP:0000613)1.82431381
150Polyuria (HP:0000103)1.82234984
151Abnormality of the fovea (HP:0000493)1.81911369
152Squamous cell carcinoma (HP:0002860)1.80858740
153Xanthomatosis (HP:0000991)1.80509346
154Steppage gait (HP:0003376)1.79873643
155Lip pit (HP:0100267)1.76207531
156Increased intramyocellular lipid droplets (HP:0012240)1.76111649
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76058083
158Abnormality of the dental pulp (HP:0006479)1.74815425
159Renal tubular dysfunction (HP:0000124)1.74520368
160Epileptic encephalopathy (HP:0200134)1.74448856
161Cerebral palsy (HP:0100021)1.74311992
162Abnormality of vitamin metabolism (HP:0100508)1.74197815
163Abnormal glucose tolerance (HP:0001952)1.73729339
164Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72969285
165Methylmalonic acidemia (HP:0002912)1.72918418
166Glycosuria (HP:0003076)1.71336663
167Abnormality of urine glucose concentration (HP:0011016)1.71336663
168Lipid accumulation in hepatocytes (HP:0006561)1.71232793
169Type II diabetes mellitus (HP:0005978)1.70828446
170Hyperinsulinemic hypoglycemia (HP:0000825)1.70559281
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.70273234
172Abnormality of midbrain morphology (HP:0002418)1.69757602
173Molar tooth sign on MRI (HP:0002419)1.69757602
174Cystic liver disease (HP:0006706)1.69683445
175Brittle hair (HP:0002299)1.69493704
176Abnormal spermatogenesis (HP:0008669)1.69321558
177Metabolic alkalosis (HP:0200114)1.68531537
178Abnormality of the renal cortex (HP:0011035)1.68298821
179Median cleft lip (HP:0000161)1.68285720
180Increased CSF lactate (HP:0002490)1.68225365
181Poor coordination (HP:0002370)1.67250766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.46255041
2STK163.27069569
3GRK53.07040883
4EPHA22.76285038
5MAPK152.75091128
6INSRR2.72080902
7TLK12.66276673
8MST1R2.60931768
9WNK42.32689388
10BLK2.18882135
11GRK12.17757564
12SIK22.04773680
13CHUK2.00689060
14IKBKB1.97371188
15IRAK11.95505731
16TNIK1.89635053
17STK391.87534356
18MAPK131.85992245
19NTRK31.84981772
20IRAK21.80180205
21MAP2K71.78400232
22IRAK31.75228951
23ABL21.73656528
24LMTK21.73490784
25MAP3K21.69304598
26ACVR1B1.58455681
27ADRBK21.54954227
28MKNK21.53501697
29NME11.48528730
30EPHA31.47699630
31GRK71.45002365
32TAOK31.42396302
33MAP3K141.41947480
34MAP4K21.41890967
35PNCK1.40062197
36ERBB31.38640391
37SIK11.37627439
38TNK21.37074694
39BMPR21.35678732
40BMPR1B1.33222117
41MAP3K51.33147912
42AKT31.31449816
43ARAF1.29165406
44NUAK11.25300897
45NEK61.25121505
46FER1.24936971
47MARK31.24205668
48WNK31.14478670
49MAP2K21.13542892
50PIK3CG1.08897795
51PBK1.07762252
52PDK41.05637994
53PDK31.05637994
54BRAF1.05472441
55LIMK11.04483807
56WNK11.04261996
57BCKDK1.03742670
58MAP3K131.01453977
59PRKCE1.01161452
60BCR0.99861662
61MAP3K120.95871366
62MST40.95245743
63GRK60.95065651
64PRKAA10.91528972
65PDK20.90799799
66MARK10.90369275
67CSNK1G10.88812559
68ZAK0.88780117
69MUSK0.88492341
70PINK10.87200969
71DYRK1A0.85541417
72DYRK20.85449952
73STK38L0.85256376
74RPS6KA50.85093849
75MINK10.84689514
76ADRBK10.84676793
77NTRK10.84325585
78FRK0.84025469
79TAOK10.83099439
80CSNK1G20.83065987
81CAMKK20.81692238
82IRAK40.79976098
83CDK30.78853684
84MAP3K40.78766222
85FLT30.78422627
86YES10.77963206
87SIK30.76444566
88VRK10.73223841
89OBSCN0.72522346
90CAMK2A0.71237623
91TRPM70.70359764
92PRKD30.69606958
93PIM20.69413084
94CAMK2B0.69294598
95MET0.68641885
96PRKACA0.68625071
97IKBKE0.67579743
98OXSR10.66384948
99SGK4940.64878799
100SGK2230.64878799
101DYRK1B0.64830412
102NME20.64528341
103DYRK30.64178915
104CAMK2D0.63980678
105ILK0.63140632
106RIPK40.62810802
107MYLK0.62708551
108TBK10.62662445
109PHKG10.61962788
110PHKG20.61962788
111HIPK20.61124926
112PIK3CA0.60635834
113PRKAA20.60372935
114MAP2K60.59123449
115UHMK10.58465534
116DAPK10.58384580
117MAP3K30.57093643
118MAP3K90.56978030
119DAPK20.56473575
120PRKD20.55217337
121MAP2K40.54645714
122MAP3K10.52645571
123PKN10.52134014
124CDC42BPA0.51858287
125FES0.50253522
126PRKCI0.49633215
127SGK20.48098592
128STK240.47961658
129PRKG10.46455840
130MAPKAPK30.45859777
131MAPK110.45852627
132CAMK2G0.45669551
133CSNK1A1L0.45649647
134MAP2K10.44105399
135CDK50.43953677
136PRPF4B0.43824912
137PAK30.43632199
138MAPK120.43468216
139PRKCG0.43235348
140PRKCQ0.42158167
141EPHA40.41852138
142PAK40.40893319
143CSNK1G30.40271415
144RAF10.40156751
145NLK0.40076701
146SRPK10.39156225
147PRKG20.37162284
148CAMK10.35437598
149PIM10.35187604
150STK30.33232239
151KSR10.32289071
152PRKCD0.31085641
153PDK10.29576076
154PDPK10.28892878
155LATS10.28419163
156CDK90.27712261
157ERBB20.27057985

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.60770213
2Systemic lupus erythematosus_Homo sapiens_hsa053223.85622916
3Oxidative phosphorylation_Homo sapiens_hsa001903.24148801
4Protein export_Homo sapiens_hsa030603.21035863
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.62215430
6Nitrogen metabolism_Homo sapiens_hsa009102.54103026
7Alcoholism_Homo sapiens_hsa050342.44588920
8Parkinsons disease_Homo sapiens_hsa050122.38673629
9Caffeine metabolism_Homo sapiens_hsa002322.24533263
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.21907019
11Nicotine addiction_Homo sapiens_hsa050332.21329425
12Alzheimers disease_Homo sapiens_hsa050102.18223449
13Chemical carcinogenesis_Homo sapiens_hsa052042.15425572
14Taste transduction_Homo sapiens_hsa047422.15173917
15Pancreatic secretion_Homo sapiens_hsa049722.04474419
16Insulin secretion_Homo sapiens_hsa049111.92939264
17Huntingtons disease_Homo sapiens_hsa050161.91387218
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86376757
19Cardiac muscle contraction_Homo sapiens_hsa042601.84500534
20Butanoate metabolism_Homo sapiens_hsa006501.83195944
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83161232
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79608381
23Collecting duct acid secretion_Homo sapiens_hsa049661.78841439
24Propanoate metabolism_Homo sapiens_hsa006401.75256693
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72203466
26Synaptic vesicle cycle_Homo sapiens_hsa047211.68198455
27Sphingolipid metabolism_Homo sapiens_hsa006001.66620636
28Serotonergic synapse_Homo sapiens_hsa047261.65687363
29Linoleic acid metabolism_Homo sapiens_hsa005911.63874561
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63807831
31Fatty acid elongation_Homo sapiens_hsa000621.63505289
32Sulfur metabolism_Homo sapiens_hsa009201.61408943
33Tryptophan metabolism_Homo sapiens_hsa003801.61383400
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60953928
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57207390
36Regulation of autophagy_Homo sapiens_hsa041401.55921439
37Selenocompound metabolism_Homo sapiens_hsa004501.51095851
38Phenylalanine metabolism_Homo sapiens_hsa003601.49451662
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48699501
40Sulfur relay system_Homo sapiens_hsa041221.47808228
41Complement and coagulation cascades_Homo sapiens_hsa046101.46202222
42GABAergic synapse_Homo sapiens_hsa047271.46182293
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46063961
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46058916
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43064126
46Morphine addiction_Homo sapiens_hsa050321.42880011
47beta-Alanine metabolism_Homo sapiens_hsa004101.42042320
48Steroid biosynthesis_Homo sapiens_hsa001001.39795620
49Ether lipid metabolism_Homo sapiens_hsa005651.38967352
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38934955
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35775994
52Glutamatergic synapse_Homo sapiens_hsa047241.33328908
53Viral carcinogenesis_Homo sapiens_hsa052031.32123551
54Tyrosine metabolism_Homo sapiens_hsa003501.31985471
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31778741
56Glutathione metabolism_Homo sapiens_hsa004801.30534937
57Arachidonic acid metabolism_Homo sapiens_hsa005901.30248827
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29185698
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25805676
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23820109
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.23509131
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23246486
63Vibrio cholerae infection_Homo sapiens_hsa051101.20972264
64Circadian entrainment_Homo sapiens_hsa047131.20642510
65Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17466948
66Protein digestion and absorption_Homo sapiens_hsa049741.11320364
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.07396177
68Fatty acid degradation_Homo sapiens_hsa000711.06761576
69Salivary secretion_Homo sapiens_hsa049700.97385208
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96211164
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95210359
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94046428
73Dopaminergic synapse_Homo sapiens_hsa047280.93889954
74Calcium signaling pathway_Homo sapiens_hsa040200.93033159
75Bile secretion_Homo sapiens_hsa049760.91717499
76Mineral absorption_Homo sapiens_hsa049780.91572031
77Circadian rhythm_Homo sapiens_hsa047100.89011163
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.83191706
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83123897
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82510676
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82424716
82Amphetamine addiction_Homo sapiens_hsa050310.81997078
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.80213706
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79921567
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.79734741
86Renin secretion_Homo sapiens_hsa049240.79674725
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79580533
88Olfactory transduction_Homo sapiens_hsa047400.78371611
89Cocaine addiction_Homo sapiens_hsa050300.76014360
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.75418726
91Glycerolipid metabolism_Homo sapiens_hsa005610.75011170
92Histidine metabolism_Homo sapiens_hsa003400.74266336
93Cholinergic synapse_Homo sapiens_hsa047250.72436923
94Rheumatoid arthritis_Homo sapiens_hsa053230.70406956
95Long-term depression_Homo sapiens_hsa047300.70262426
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68186770
97Vitamin digestion and absorption_Homo sapiens_hsa049770.67505381
98Retinol metabolism_Homo sapiens_hsa008300.66125023
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65913680
100Staphylococcus aureus infection_Homo sapiens_hsa051500.65734447
101Other glycan degradation_Homo sapiens_hsa005110.65719423
102Fat digestion and absorption_Homo sapiens_hsa049750.65592661
103RNA polymerase_Homo sapiens_hsa030200.65161341
104Metabolic pathways_Homo sapiens_hsa011000.65089690
105Vitamin B6 metabolism_Homo sapiens_hsa007500.63463256
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62821859
107Proteasome_Homo sapiens_hsa030500.61085423
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58613371
109cAMP signaling pathway_Homo sapiens_hsa040240.58538807
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.55266126
111Lysosome_Homo sapiens_hsa041420.54783046
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54495125
113Axon guidance_Homo sapiens_hsa043600.54343104
114Starch and sucrose metabolism_Homo sapiens_hsa005000.53331545
115ABC transporters_Homo sapiens_hsa020100.52045612
116PPAR signaling pathway_Homo sapiens_hsa033200.51083890
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50769641
118Purine metabolism_Homo sapiens_hsa002300.48733949
119Peroxisome_Homo sapiens_hsa041460.47777610
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45390582
121Basal transcription factors_Homo sapiens_hsa030220.44496063
122Long-term potentiation_Homo sapiens_hsa047200.44401839
123Lysine degradation_Homo sapiens_hsa003100.44144642
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43562158
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.43341803
126p53 signaling pathway_Homo sapiens_hsa041150.42297927
127Type I diabetes mellitus_Homo sapiens_hsa049400.42135199
128Dorso-ventral axis formation_Homo sapiens_hsa043200.40714004
129Ovarian steroidogenesis_Homo sapiens_hsa049130.39733115
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39583805
131Gastric acid secretion_Homo sapiens_hsa049710.39514065
132FoxO signaling pathway_Homo sapiens_hsa040680.39161690
133Pyrimidine metabolism_Homo sapiens_hsa002400.38978189
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38575717
135Pyruvate metabolism_Homo sapiens_hsa006200.36740707
136Arginine and proline metabolism_Homo sapiens_hsa003300.36305511
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.35137970
138Fructose and mannose metabolism_Homo sapiens_hsa000510.34858583
139Fanconi anemia pathway_Homo sapiens_hsa034600.34846722
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34665388
141Melanoma_Homo sapiens_hsa052180.33461909
142Oxytocin signaling pathway_Homo sapiens_hsa049210.32733631
143Melanogenesis_Homo sapiens_hsa049160.32215524
144Folate biosynthesis_Homo sapiens_hsa007900.31567493
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31549378
146Allograft rejection_Homo sapiens_hsa053300.31383566
147Hedgehog signaling pathway_Homo sapiens_hsa043400.31180713
148Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30872467
149Phagosome_Homo sapiens_hsa041450.30099768
150Autoimmune thyroid disease_Homo sapiens_hsa053200.28680639
151Prolactin signaling pathway_Homo sapiens_hsa049170.27454587
152Thyroid hormone synthesis_Homo sapiens_hsa049180.27445170
153Arginine biosynthesis_Homo sapiens_hsa002200.26737535
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26087544
155Hepatitis C_Homo sapiens_hsa051600.25183282

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