HS3ST4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63738862
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51796436
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51396534
4vocalization behavior (GO:0071625)5.50036232
5synaptic vesicle exocytosis (GO:0016079)5.40433256
6protein localization to synapse (GO:0035418)5.07303841
7neuron cell-cell adhesion (GO:0007158)5.04899815
8regulation of glutamate receptor signaling pathway (GO:1900449)5.01363370
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.92093587
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.91004532
11locomotory exploration behavior (GO:0035641)4.89614648
12glutamate receptor signaling pathway (GO:0007215)4.77212660
13cerebellar granule cell differentiation (GO:0021707)4.75739161
14sodium ion export (GO:0071436)4.75648207
15glutamate secretion (GO:0014047)4.75255389
16synaptic vesicle maturation (GO:0016188)4.75052603
17central nervous system myelination (GO:0022010)4.73334665
18axon ensheathment in central nervous system (GO:0032291)4.73334665
19neuronal action potential propagation (GO:0019227)4.70202832
20regulation of synaptic vesicle exocytosis (GO:2000300)4.62942614
21dendritic spine morphogenesis (GO:0060997)4.62212228
22exploration behavior (GO:0035640)4.43686746
23L-amino acid import (GO:0043092)4.42315354
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.42018141
25neuron recognition (GO:0008038)4.37640364
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32263013
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31376727
28synaptic vesicle docking involved in exocytosis (GO:0016081)4.29292280
29synaptic transmission, glutamatergic (GO:0035249)4.27487444
30neuron-neuron synaptic transmission (GO:0007270)4.20065045
31regulation of neuronal synaptic plasticity (GO:0048168)4.18516155
32regulation of voltage-gated calcium channel activity (GO:1901385)4.13356666
33layer formation in cerebral cortex (GO:0021819)4.12097530
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.10340126
35regulation of synaptic vesicle transport (GO:1902803)4.09994198
36regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04762003
37regulation of synapse structural plasticity (GO:0051823)4.02768030
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.00484264
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.99846340
40neuronal ion channel clustering (GO:0045161)3.95426808
41neurotransmitter-gated ion channel clustering (GO:0072578)3.94343085
42presynaptic membrane assembly (GO:0097105)3.92323296
43cell differentiation in hindbrain (GO:0021533)3.89308230
44positive regulation of membrane potential (GO:0045838)3.88484122
45regulation of postsynaptic membrane potential (GO:0060078)3.87754722
46axonal fasciculation (GO:0007413)3.85991087
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85791648
48amino acid import (GO:0043090)3.85490115
49neurotransmitter secretion (GO:0007269)3.81229111
50long-term memory (GO:0007616)3.77585266
51regulation of dendritic spine morphogenesis (GO:0061001)3.75800311
52potassium ion homeostasis (GO:0055075)3.73757988
53neuromuscular process controlling posture (GO:0050884)3.70083133
54response to histamine (GO:0034776)3.69467113
55postsynaptic membrane organization (GO:0001941)3.68245172
56transmission of nerve impulse (GO:0019226)3.67454906
57behavioral fear response (GO:0001662)3.65930531
58behavioral defense response (GO:0002209)3.65930531
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.65218261
60presynaptic membrane organization (GO:0097090)3.64792183
61negative regulation of dendrite morphogenesis (GO:0050774)3.63182521
62synaptic vesicle endocytosis (GO:0048488)3.62520644
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61839413
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.60244133
65long-term synaptic potentiation (GO:0060291)3.58826055
66proline transport (GO:0015824)3.58543560
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57093863
68positive regulation of synapse maturation (GO:0090129)3.55623310
69cell communication by electrical coupling (GO:0010644)3.54516127
70regulation of synaptic plasticity (GO:0048167)3.54485551
71adult walking behavior (GO:0007628)3.54105281
72neuromuscular process controlling balance (GO:0050885)3.52413278
73potassium ion import (GO:0010107)3.50916669
74chemosensory behavior (GO:0007635)3.43477619
75regulation of vesicle fusion (GO:0031338)3.42954599
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.41603592
77regulation of neurotransmitter secretion (GO:0046928)3.41100231
78neuromuscular synaptic transmission (GO:0007274)3.39417572
79cell migration in hindbrain (GO:0021535)3.35832655
80dendritic spine organization (GO:0097061)3.34441937
81fear response (GO:0042596)3.34439506
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34415659
83neurotransmitter transport (GO:0006836)3.33356242
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32898936
85gamma-aminobutyric acid transport (GO:0015812)3.32113103
86regulation of dendritic spine development (GO:0060998)3.31854314
87regulation of glutamate secretion (GO:0014048)3.31847233
88positive regulation of neurotransmitter secretion (GO:0001956)3.30959009
89neuromuscular process (GO:0050905)3.28073145
90positive regulation of dendritic spine development (GO:0060999)3.26869903
91membrane depolarization (GO:0051899)3.24827537
92positive regulation of dendritic spine morphogenesis (GO:0061003)3.23490977
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20626545
94cellular sodium ion homeostasis (GO:0006883)3.20250004
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20203521
96cellular potassium ion homeostasis (GO:0030007)3.16128355
97serotonin receptor signaling pathway (GO:0007210)3.13994642
98startle response (GO:0001964)3.13333913
99auditory behavior (GO:0031223)3.12387210
100behavioral response to cocaine (GO:0048148)3.12301468
101innervation (GO:0060384)3.12060040
102regulation of neurotransmitter transport (GO:0051588)3.11779617
103learning (GO:0007612)3.10999504
104righting reflex (GO:0060013)3.10856429
105dendrite morphogenesis (GO:0048813)3.08845540
106synapse assembly (GO:0007416)3.08075725
107positive regulation of neurotransmitter transport (GO:0051590)3.06061794
108cochlea development (GO:0090102)3.04455424
109membrane hyperpolarization (GO:0060081)3.03505543
110neurotransmitter uptake (GO:0001504)3.02158727
111positive regulation of synapse assembly (GO:0051965)3.01721497
112cerebellar Purkinje cell layer development (GO:0021680)3.00932672
113regulation of synaptic transmission (GO:0050804)2.98048435
114regulation of respiratory system process (GO:0044065)2.97047733
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.96021552
116synaptic transmission (GO:0007268)2.95967519
117regulation of neurotransmitter levels (GO:0001505)2.95585973
118central nervous system projection neuron axonogenesis (GO:0021952)2.93278410
119activation of protein kinase A activity (GO:0034199)2.93237009
120positive regulation of dendrite development (GO:1900006)2.90363057
121membrane depolarization during action potential (GO:0086010)2.90276499
122positive regulation of synaptic transmission (GO:0050806)2.89334974
123response to auditory stimulus (GO:0010996)2.89287469
124cerebellar Purkinje cell differentiation (GO:0021702)2.89194264
125regulation of synapse maturation (GO:0090128)2.89084845
126regulation of synaptic transmission, GABAergic (GO:0032228)2.87423860
127vesicle transport along microtubule (GO:0047496)2.86695195
128negative regulation of dendrite development (GO:2000171)2.86653749
129synapse organization (GO:0050808)2.85846657
130detection of calcium ion (GO:0005513)2.85772013
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85500180
132regulation of ARF protein signal transduction (GO:0032012)2.85110768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.26378737
2GBX2_23144817_ChIP-Seq_PC3_Human3.76448725
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21493700
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15429193
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97364995
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.68927246
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68245009
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67774141
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67774141
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62867961
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59869299
12REST_21632747_ChIP-Seq_MESCs_Mouse2.53902967
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47700397
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42469084
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40036574
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.37399782
17TAF15_26573619_Chip-Seq_HEK293_Human2.32715838
18AR_21572438_ChIP-Seq_LNCaP_Human2.30204387
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24703277
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22046782
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.18468184
22DROSHA_22980978_ChIP-Seq_HELA_Human2.14059622
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13101555
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.09097305
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07553739
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.01872210
27* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97895107
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97475423
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94945687
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.94507971
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89698867
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89462762
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84340059
34SMAD4_21799915_ChIP-Seq_A2780_Human1.74041751
35* P300_19829295_ChIP-Seq_ESCs_Human1.68797138
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67590567
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64364446
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63741194
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.63480089
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61921011
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60734918
42FUS_26573619_Chip-Seq_HEK293_Human1.52579004
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50551253
44ZNF274_21170338_ChIP-Seq_K562_Hela1.48352772
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48048135
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46010604
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45493362
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44194876
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43590417
50RNF2_27304074_Chip-Seq_NSC_Mouse1.41192268
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40866824
52VDR_22108803_ChIP-Seq_LS180_Human1.38003948
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36681736
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36462873
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.35760013
56KDM2B_26808549_Chip-Seq_K562_Human1.35027798
57IGF1R_20145208_ChIP-Seq_DFB_Human1.33420326
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32785122
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.32452057
60AR_25329375_ChIP-Seq_VCAP_Human1.32325451
61CTCF_27219007_Chip-Seq_Bcells_Human1.31676273
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31292075
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.30122423
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.29443765
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25234126
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.24990544
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23766468
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23014238
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22702613
70STAT3_23295773_ChIP-Seq_U87_Human1.22433478
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20460147
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20021966
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19697172
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18695438
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.16894179
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16643355
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15438121
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12545208
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.12049980
80ER_23166858_ChIP-Seq_MCF-7_Human1.11944024
81* TCF4_23295773_ChIP-Seq_U87_Human1.11874401
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11370468
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.10390744
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09881316
85RUNX2_22187159_ChIP-Seq_PCA_Human1.09358507
86* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09165503
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.08806962
88* AR_19668381_ChIP-Seq_PC3_Human1.07410262
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06983485
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06922593
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06814168
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06814168
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06772536
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.06015806
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05427478
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04434020
97TP53_18474530_ChIP-ChIP_U2OS_Human1.02958332
98JUN_21703547_ChIP-Seq_K562_Human1.02513322
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02509537
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02420376
101TP53_16413492_ChIP-PET_HCT116_Human1.01650553
102AHR_22903824_ChIP-Seq_MCF-7_Human1.01199523
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00591997
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99368410
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98422513
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96756154
107KDM2B_26808549_Chip-Seq_REH_Human0.96024913
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95973306
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95411119
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94331609
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.93656331
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93656037
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.93546831
114* BCAT_22108803_ChIP-Seq_LS180_Human0.92552540
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.91703269
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91375300
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90922838
118* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89059585
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.88553696
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86355817
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83770278
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82715996
123KLF4_19829295_ChIP-Seq_ESCs_Human0.82229911
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81251780
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80037757
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78874852
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74954650
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.74037383
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73625254
130OCT4_19829295_ChIP-Seq_ESCs_Human0.73593420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07871752
2MP0003880_abnormal_central_pattern5.63547842
3MP0003635_abnormal_synaptic_transmissio4.14571641
4MP0004270_analgesia3.58194208
5MP0009745_abnormal_behavioral_response3.48895738
6MP0002063_abnormal_learning/memory/cond3.40793994
7MP0002064_seizures3.19551440
8MP0001968_abnormal_touch/_nociception3.10247672
9MP0002572_abnormal_emotion/affect_behav2.97981576
10MP0009046_muscle_twitch2.84549950
11MP0001486_abnormal_startle_reflex2.79208101
12MP0002272_abnormal_nervous_system2.62208753
13MP0005423_abnormal_somatic_nervous2.60227556
14MP0002734_abnormal_mechanical_nocicepti2.58885191
15MP0001440_abnormal_grooming_behavior2.55490276
16MP0002736_abnormal_nociception_after2.48213756
17MP0001501_abnormal_sleep_pattern2.32729267
18MP0002822_catalepsy2.30196866
19MP0002735_abnormal_chemical_nociception2.17431796
20MP0002067_abnormal_sensory_capabilities2.07108455
21MP0000778_abnormal_nervous_system2.05015057
22MP0006276_abnormal_autonomic_nervous1.99370022
23MP0002733_abnormal_thermal_nociception1.98931752
24MP0001970_abnormal_pain_threshold1.95470008
25MP0002184_abnormal_innervation1.89610254
26MP0002557_abnormal_social/conspecific_i1.79815101
27MP0001984_abnormal_olfaction1.77663095
28MP0008569_lethality_at_weaning1.77646360
29MP0004924_abnormal_behavior1.67407101
30MP0005386_behavior/neurological_phenoty1.67407101
31MP0001529_abnormal_vocalization1.67050147
32MP0001188_hyperpigmentation1.64454125
33MP0003879_abnormal_hair_cell1.60872071
34MP0009780_abnormal_chondrocyte_physiolo1.59182765
35MP0009379_abnormal_foot_pigmentation1.59153610
36MP0004811_abnormal_neuron_physiology1.57056916
37MP0000566_synostosis1.51390745
38MP0004142_abnormal_muscle_tone1.48812416
39MP0003329_amyloid_beta_deposits1.47284299
40MP0000955_abnormal_spinal_cord1.47100279
41MP0002882_abnormal_neuron_morphology1.45057596
42MP0005646_abnormal_pituitary_gland1.42124339
43MP0002066_abnormal_motor_capabilities/c1.41226025
44MP0001905_abnormal_dopamine_level1.35421359
45MP0003787_abnormal_imprinting1.31155749
46MP0005551_abnormal_eye_electrophysiolog1.30960066
47MP0002909_abnormal_adrenal_gland1.30867705
48MP0005645_abnormal_hypothalamus_physiol1.30821432
49MP0001502_abnormal_circadian_rhythm1.27642387
50MP0004742_abnormal_vestibular_system1.25790507
51MP0005409_darkened_coat_color1.23099176
52MP0004858_abnormal_nervous_system1.21487197
53MP0002837_dystrophic_cardiac_calcinosis1.20700282
54MP0001346_abnormal_lacrimal_gland1.18457738
55MP0002152_abnormal_brain_morphology1.12856161
56MP0004885_abnormal_endolymph1.12587826
57MP0003122_maternal_imprinting1.11463404
58MP0003633_abnormal_nervous_system1.10563280
59MP0003283_abnormal_digestive_organ1.09366802
60MP0003123_paternal_imprinting1.08730771
61MP0010386_abnormal_urinary_bladder1.02494842
62MP0000579_abnormal_nail_morphology1.00857762
63MP0001986_abnormal_taste_sensitivity0.99900665
64MP0001963_abnormal_hearing_physiology0.99704099
65MP0000751_myopathy0.99086157
66MP0005377_hearing/vestibular/ear_phenot0.98232487
67MP0003878_abnormal_ear_physiology0.98232487
68MP0002653_abnormal_ependyma_morphology0.97992836
69MP0004145_abnormal_muscle_electrophysio0.96639179
70MP0003631_nervous_system_phenotype0.95442516
71MP0002229_neurodegeneration0.94086212
72MP0005499_abnormal_olfactory_system0.94042816
73MP0005394_taste/olfaction_phenotype0.94042816
74MP0000569_abnormal_digit_pigmentation0.93654843
75MP0002069_abnormal_eating/drinking_beha0.92882376
76MP0002102_abnormal_ear_morphology0.92725624
77MP0000631_abnormal_neuroendocrine_gland0.91433575
78MP0002752_abnormal_somatic_nervous0.90351286
79MP0008874_decreased_physiological_sensi0.90321725
80MP0005535_abnormal_body_temperature0.88151288
81MP0002876_abnormal_thyroid_physiology0.84707708
82MP0008961_abnormal_basal_metabolism0.83339415
83MP0004085_abnormal_heartbeat0.83125381
84MP0001485_abnormal_pinna_reflex0.81926260
85MP0002090_abnormal_vision0.81157179
86MP0004215_abnormal_myocardial_fiber0.80414636
87MP0006292_abnormal_olfactory_placode0.79485306
88MP0001177_atelectasis0.77794715
89MP0008872_abnormal_physiological_respon0.75988642
90MP0000026_abnormal_inner_ear0.75554044
91MP0000920_abnormal_myelination0.75360793
92MP0004484_altered_response_of0.74936676
93MP0003634_abnormal_glial_cell0.73328236
94MP0001664_abnormal_digestion0.72899278
95MP0004510_myositis0.66991231
96MP0003137_abnormal_impulse_conducting0.66834321
97MP0002234_abnormal_pharynx_morphology0.66537982
98MP0003011_delayed_dark_adaptation0.63579779
99MP0002638_abnormal_pupillary_reflex0.63424238
100MP0003632_abnormal_nervous_system0.61827039
101MP0003075_altered_response_to0.61313178
102MP0008877_abnormal_DNA_methylation0.59135421
103MP0003861_abnormal_nervous_system0.59111453
104MP0001299_abnormal_eye_distance/0.57472637
105MP0000013_abnormal_adipose_tissue0.57054134
106MP0005623_abnormal_meninges_morphology0.55223296
107MP0000604_amyloidosis0.54903403
108MP0010768_mortality/aging0.54173762
109MP0003690_abnormal_glial_cell0.54005173
110MP0001348_abnormal_lacrimal_gland0.53858227
111MP0003136_yellow_coat_color0.53483782
112MP0006072_abnormal_retinal_apoptosis0.53423440
113MP0003938_abnormal_ear_development0.53195882
114MP0001943_abnormal_respiration0.52771449
115MP0010769_abnormal_survival0.50659846
116MP0004147_increased_porphyrin_level0.50633420
117MP0002082_postnatal_lethality0.50373319
118MP0010770_preweaning_lethality0.50373319
119MP0004130_abnormal_muscle_cell0.48880240
120MP0005167_abnormal_blood-brain_barrier0.47321751
121MP0002089_abnormal_postnatal_growth/wei0.46486574

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.47517695
2Myokymia (HP:0002411)6.39236923
3Focal seizures (HP:0007359)6.10288246
4Visual hallucinations (HP:0002367)5.37565183
5Epileptic encephalopathy (HP:0200134)5.27200757
6Febrile seizures (HP:0002373)4.95207187
7Atonic seizures (HP:0010819)4.92817789
8Absence seizures (HP:0002121)4.75191118
9Dialeptic seizures (HP:0011146)4.38951761
10Generalized tonic-clonic seizures (HP:0002069)4.33865811
11Progressive cerebellar ataxia (HP:0002073)4.12737791
12Broad-based gait (HP:0002136)3.81607669
13Hyperventilation (HP:0002883)3.78287129
14Supranuclear gaze palsy (HP:0000605)3.41943605
15Amblyopia (HP:0000646)3.38726187
16Gaze-evoked nystagmus (HP:0000640)3.20830749
17Mutism (HP:0002300)3.19547088
18Impaired vibration sensation in the lower limbs (HP:0002166)3.15234466
19Action tremor (HP:0002345)3.09658488
20Dysdiadochokinesis (HP:0002075)3.08831433
21Drooling (HP:0002307)3.06799802
22Excessive salivation (HP:0003781)3.06799802
23Hemiplegia (HP:0002301)3.02188754
24Cerebral inclusion bodies (HP:0100314)3.01386325
25Poor eye contact (HP:0000817)2.99596406
26Dysmetria (HP:0001310)2.90887062
27Anxiety (HP:0000739)2.90028820
28Urinary bladder sphincter dysfunction (HP:0002839)2.85060399
29Annular pancreas (HP:0001734)2.84915127
30Diplopia (HP:0000651)2.84041900
31Abnormality of binocular vision (HP:0011514)2.84041900
32Neurofibrillary tangles (HP:0002185)2.83317220
33Truncal ataxia (HP:0002078)2.82712471
34Ankle clonus (HP:0011448)2.81109017
35Abnormal eating behavior (HP:0100738)2.77911192
36Depression (HP:0000716)2.74587415
37Absent speech (HP:0001344)2.72699391
38Hemiparesis (HP:0001269)2.70881610
39Split foot (HP:0001839)2.67296541
40Cerebral hypomyelination (HP:0006808)2.65248167
41Fetal akinesia sequence (HP:0001989)2.63177140
42Papilledema (HP:0001085)2.62926382
43Absent/shortened dynein arms (HP:0200106)2.61243980
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.61243980
45Epileptiform EEG discharges (HP:0011182)2.60849546
46Slow saccadic eye movements (HP:0000514)2.57811078
47Impaired social interactions (HP:0000735)2.56602833
48Abnormal social behavior (HP:0012433)2.56602833
49Polyphagia (HP:0002591)2.56178824
50Insidious onset (HP:0003587)2.55012890
51Termporal pattern (HP:0011008)2.55012890
52Tetraplegia (HP:0002445)2.49638496
53Urinary urgency (HP:0000012)2.47249631
54EEG with generalized epileptiform discharges (HP:0011198)2.44397904
55Genetic anticipation (HP:0003743)2.42692351
56Aplasia involving bones of the extremities (HP:0009825)2.41545775
57Aplasia involving bones of the upper limbs (HP:0009823)2.41545775
58Aplasia of the phalanges of the hand (HP:0009802)2.41545775
59Postural tremor (HP:0002174)2.40848348
60Postural instability (HP:0002172)2.40162493
61Generalized myoclonic seizures (HP:0002123)2.39189944
62Torticollis (HP:0000473)2.35514440
63Abnormality of saccadic eye movements (HP:0000570)2.34291693
64Spastic gait (HP:0002064)2.34102382
65Peripheral hypomyelination (HP:0007182)2.32383263
66Impaired smooth pursuit (HP:0007772)2.32365722
67Scanning speech (HP:0002168)2.32211289
68Abnormality of the corticospinal tract (HP:0002492)2.30268506
69Bronchomalacia (HP:0002780)2.29612405
70Retinal dysplasia (HP:0007973)2.29180387
71Gait imbalance (HP:0002141)2.28955128
72Stereotypic behavior (HP:0000733)2.28448229
73Abnormality of salivation (HP:0100755)2.22142303
74Status epilepticus (HP:0002133)2.19456965
75Focal dystonia (HP:0004373)2.19326700
76Hypsarrhythmia (HP:0002521)2.18968577
77Limb dystonia (HP:0002451)2.18284584
78Progressive inability to walk (HP:0002505)2.17702665
79Bradykinesia (HP:0002067)2.16320485
80Delusions (HP:0000746)2.14248924
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.14222464
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14222464
83Inability to walk (HP:0002540)2.13235848
84Limb ataxia (HP:0002070)2.11770475
85Impaired vibratory sensation (HP:0002495)2.10050885
86Protruding tongue (HP:0010808)2.06405244
87Ventricular fibrillation (HP:0001663)2.05783446
88Choreoathetosis (HP:0001266)2.05683265
89Akinesia (HP:0002304)2.05557031
90Morphological abnormality of the pyramidal tract (HP:0002062)2.04377439
91Abnormal ciliary motility (HP:0012262)2.02959518
92Agitation (HP:0000713)2.00588806
93Hyperthyroidism (HP:0000836)1.99547589
94Rigidity (HP:0002063)1.98525806
95Megalencephaly (HP:0001355)1.97686509
96Partial duplication of thumb phalanx (HP:0009944)1.97254601
97Abnormality of the lower motor neuron (HP:0002366)1.96962415
98Craniofacial dystonia (HP:0012179)1.93798819
99Inappropriate behavior (HP:0000719)1.93519606
100Esotropia (HP:0000565)1.92992745
101Obstructive sleep apnea (HP:0002870)1.92594100
102Amyotrophic lateral sclerosis (HP:0007354)1.91263743
103Incomplete penetrance (HP:0003829)1.89420219
104Blue irides (HP:0000635)1.89394244
105Lower limb muscle weakness (HP:0007340)1.87830915
106Clonus (HP:0002169)1.87379340
107Abnormality of ocular smooth pursuit (HP:0000617)1.86895393
108Cutaneous finger syndactyly (HP:0010554)1.85656827
109Thickened helices (HP:0000391)1.85636779
110Neuronal loss in central nervous system (HP:0002529)1.85531058
111Medial flaring of the eyebrow (HP:0010747)1.84162248
112Spastic tetraparesis (HP:0001285)1.83831655
113Psychosis (HP:0000709)1.83177797
114Specific learning disability (HP:0001328)1.82410646
115Dysmetric saccades (HP:0000641)1.80503371
116Cutaneous syndactyly (HP:0012725)1.77568037
117Sleep apnea (HP:0010535)1.77244818
118Congenital primary aphakia (HP:0007707)1.76715243
119Widely spaced teeth (HP:0000687)1.75843649
120Type II lissencephaly (HP:0007260)1.73807988
121Abnormal respiratory motile cilium physiology (HP:0012261)1.72274596
122Increased circulating renin level (HP:0000848)1.71147395
123Rapidly progressive (HP:0003678)1.70815665
124Intention tremor (HP:0002080)1.70347805
125Bundle branch block (HP:0011710)1.68183837
126Partial duplication of the phalanx of hand (HP:0009999)1.67269322
127Apathy (HP:0000741)1.64270434
128Turricephaly (HP:0000262)1.62530335
129Abnormal EKG (HP:0003115)1.59901729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.52020607
2NTRK34.14419969
3MAP3K93.68477517
4MARK13.20613758
5RIPK43.18038825
6MAP3K43.13807410
7CASK2.81044523
8MAP2K72.77388010
9MINK12.45894526
10NTRK22.17043618
11DAPK22.15925579
12MAP3K122.08454535
13CDK191.91328372
14PNCK1.88526311
15PAK61.87785959
16ARAF1.87626039
17TNIK1.87544691
18MAP2K41.86526917
19MAP3K131.79181638
20SIK21.72797380
21KSR21.71495445
22PLK21.69191784
23KSR11.64399100
24MAPK131.63895636
25BMPR21.54688998
26CDK51.45340376
27GRK51.44940786
28PRPF4B1.36799461
29DAPK11.36249164
30CAMKK11.31246479
31FES1.26257907
32NME11.22517599
33OXSR11.19974845
34NTRK11.19500312
35CAMK2A1.14900726
36ALK1.13769510
37PRKD31.13264814
38PRKCG1.12970199
39UHMK11.09975952
40FGFR21.04933364
41DYRK1A1.02840655
42RAF11.00735193
43PTK2B0.98454218
44FGR0.97486629
45PHKG10.96582146
46PHKG20.96582146
47CAMK2B0.91710568
48STK380.91516305
49RIPK10.90378922
50STK110.87352675
51LATS20.85371304
52MAPK150.84593189
53MAP3K20.84426497
54CDK180.84419920
55CDK140.83429644
56CDK150.83097638
57CAMKK20.81102022
58CAMK10.80930881
59PAK30.79491883
60MAP3K60.78347103
61SGK30.77455984
62CDK11A0.73092617
63SGK10.68818446
64CSNK1G20.67372566
65TYRO30.66728804
66MARK20.63174528
67PRKCE0.62175755
68SGK2230.60833409
69SGK4940.60833409
70GRK70.56120665
71PKN10.56033565
72BRAF0.55693516
73BRSK10.53645335
74PDK10.53029368
75CAMK2D0.52813933
76PDPK10.50423175
77ERBB20.48739914
78WNK30.48707487
79CAMK1G0.48635421
80MAPK120.46459815
81TNK20.46390949
82RET0.45632644
83DMPK0.44833383
84PRKCZ0.43675131
85ROCK20.43408154
86SGK20.42019301
87IRAK20.41639991
88FYN0.41447555
89FER0.40460967
90CAMK1D0.39762975
91TAOK10.39762949
92NEK60.39682261
93MAPK70.39167140
94CDK30.38360309
95CAMK2G0.38007740
96RPS6KA30.37521520
97MAP3K10.37356334
98CAMK40.36971336
99MAP2K10.36677732
100PINK10.35919024
101BCR0.35527326
102ADRBK10.33997813
103MOS0.33703137
104MAPK100.33492378
105PRKG10.33179554
106PRKCB0.31948445
107MUSK0.31848914
108PRKCA0.31841049
109PRKACA0.31708876
110MAP3K70.31677583
111PRKCH0.31432030
112FGFR10.30923031
113WNK40.30894613
114DAPK30.30268485
115DYRK20.28649986
116RPS6KB10.28419932
117MAP3K110.27888854
118MAPKAPK50.27342623
119MAPK80.26747267
120CSNK1A10.26330384
121GSK3B0.25943800
122CSNK1E0.23477643
123PIK3CA0.22363147
124WNK10.22243110

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08311350
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09619719
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92131973
4Olfactory transduction_Homo sapiens_hsa047402.79574349
5Glutamatergic synapse_Homo sapiens_hsa047242.74159458
6Morphine addiction_Homo sapiens_hsa050322.72701922
7GABAergic synapse_Homo sapiens_hsa047272.70000259
8Long-term potentiation_Homo sapiens_hsa047202.69690388
9Circadian entrainment_Homo sapiens_hsa047132.68436421
10Amphetamine addiction_Homo sapiens_hsa050312.51091791
11Salivary secretion_Homo sapiens_hsa049702.19153162
12Dopaminergic synapse_Homo sapiens_hsa047282.15679992
13Taste transduction_Homo sapiens_hsa047422.10166285
14Serotonergic synapse_Homo sapiens_hsa047262.04684898
15Insulin secretion_Homo sapiens_hsa049111.92722150
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88407209
17Renin secretion_Homo sapiens_hsa049241.88050300
18Cholinergic synapse_Homo sapiens_hsa047251.87419773
19Gastric acid secretion_Homo sapiens_hsa049711.83360124
20Collecting duct acid secretion_Homo sapiens_hsa049661.76368951
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75582420
22Long-term depression_Homo sapiens_hsa047301.74603526
23Calcium signaling pathway_Homo sapiens_hsa040201.71945599
24Oxytocin signaling pathway_Homo sapiens_hsa049211.71086016
25Cocaine addiction_Homo sapiens_hsa050301.57247289
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54803189
27GnRH signaling pathway_Homo sapiens_hsa049121.43425424
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39894513
29Gap junction_Homo sapiens_hsa045401.39760857
30Vitamin B6 metabolism_Homo sapiens_hsa007501.38129033
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37721716
32Axon guidance_Homo sapiens_hsa043601.35416513
33Cardiac muscle contraction_Homo sapiens_hsa042601.31147594
34cAMP signaling pathway_Homo sapiens_hsa040241.25436476
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25254220
36Phototransduction_Homo sapiens_hsa047441.16763181
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15032595
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12964993
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12607317
40Melanogenesis_Homo sapiens_hsa049161.07917348
41ErbB signaling pathway_Homo sapiens_hsa040121.05115604
42Glioma_Homo sapiens_hsa052141.01830671
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01563472
44Estrogen signaling pathway_Homo sapiens_hsa049151.01452824
45Vibrio cholerae infection_Homo sapiens_hsa051100.98204121
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.98069423
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96623218
48Type II diabetes mellitus_Homo sapiens_hsa049300.96494791
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91970646
50Alzheimers disease_Homo sapiens_hsa050100.89304925
51Oxidative phosphorylation_Homo sapiens_hsa001900.86329321
52Pancreatic secretion_Homo sapiens_hsa049720.83834019
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83301247
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81924355
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.76190045
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.76085260
57Dorso-ventral axis formation_Homo sapiens_hsa043200.75316514
58Dilated cardiomyopathy_Homo sapiens_hsa054140.73723590
59MAPK signaling pathway_Homo sapiens_hsa040100.73634609
60Choline metabolism in cancer_Homo sapiens_hsa052310.72030662
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71459364
62Oocyte meiosis_Homo sapiens_hsa041140.70390858
63Ras signaling pathway_Homo sapiens_hsa040140.69242023
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67641580
65Thyroid hormone synthesis_Homo sapiens_hsa049180.66512528
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65021214
67African trypanosomiasis_Homo sapiens_hsa051430.64683071
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64454539
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63104226
70VEGF signaling pathway_Homo sapiens_hsa043700.62301945
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.60664976
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57896996
73Hippo signaling pathway_Homo sapiens_hsa043900.56255804
74Parkinsons disease_Homo sapiens_hsa050120.55902321
75Histidine metabolism_Homo sapiens_hsa003400.55038434
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54336683
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54308548
78Rap1 signaling pathway_Homo sapiens_hsa040150.54008501
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53411256
80Wnt signaling pathway_Homo sapiens_hsa043100.51703760
81Fatty acid biosynthesis_Homo sapiens_hsa000610.50925771
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49357512
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46900262
84Glucagon signaling pathway_Homo sapiens_hsa049220.46361816
85Alcoholism_Homo sapiens_hsa050340.44509104
86Nitrogen metabolism_Homo sapiens_hsa009100.43506854
87Renal cell carcinoma_Homo sapiens_hsa052110.42913103
88Prion diseases_Homo sapiens_hsa050200.41822059
89Arginine and proline metabolism_Homo sapiens_hsa003300.40863224
90Circadian rhythm_Homo sapiens_hsa047100.40143630
91Ovarian steroidogenesis_Homo sapiens_hsa049130.39151841
92Hedgehog signaling pathway_Homo sapiens_hsa043400.39148660
93Ether lipid metabolism_Homo sapiens_hsa005650.38754199
94Inositol phosphate metabolism_Homo sapiens_hsa005620.38716710
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37612731
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.37071096
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36963939
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35556007
99Huntingtons disease_Homo sapiens_hsa050160.34703316
100Rheumatoid arthritis_Homo sapiens_hsa053230.34566450
101Type I diabetes mellitus_Homo sapiens_hsa049400.33559933
102Basal cell carcinoma_Homo sapiens_hsa052170.33147126
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32551940
104Mineral absorption_Homo sapiens_hsa049780.32444861
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31512852
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30486410
107Non-small cell lung cancer_Homo sapiens_hsa052230.26804383
108Chemokine signaling pathway_Homo sapiens_hsa040620.26457762
109mTOR signaling pathway_Homo sapiens_hsa041500.26170388
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25482567
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.25239267
112Endocytosis_Homo sapiens_hsa041440.25008029
113Tight junction_Homo sapiens_hsa045300.24590760
114beta-Alanine metabolism_Homo sapiens_hsa004100.23815862
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23792809
116Bile secretion_Homo sapiens_hsa049760.22647368
117Melanoma_Homo sapiens_hsa052180.20729936

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »