HS3ST3B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.27201097
2L-phenylalanine catabolic process (GO:0006559)7.27201097
3L-phenylalanine metabolic process (GO:0006558)6.96231229
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.96231229
5aromatic amino acid family catabolic process (GO:0009074)6.61266280
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.14405066
7tryptophan catabolic process (GO:0006569)6.03077066
8indole-containing compound catabolic process (GO:0042436)6.03077066
9indolalkylamine catabolic process (GO:0046218)6.03077066
10kynurenine metabolic process (GO:0070189)5.94938905
11urea metabolic process (GO:0019627)5.83324379
12urea cycle (GO:0000050)5.83324379
13bile acid biosynthetic process (GO:0006699)5.82279068
14tryptophan metabolic process (GO:0006568)5.69340895
15glyoxylate metabolic process (GO:0046487)5.58975881
16negative regulation of fibrinolysis (GO:0051918)5.58241223
17alpha-linolenic acid metabolic process (GO:0036109)5.56881541
18protein carboxylation (GO:0018214)5.52327774
19peptidyl-glutamic acid carboxylation (GO:0017187)5.52327774
20high-density lipoprotein particle remodeling (GO:0034375)5.45712251
21regulation of protein activation cascade (GO:2000257)5.43084444
22complement activation, alternative pathway (GO:0006957)5.39065960
23regulation of fibrinolysis (GO:0051917)5.38461180
24nitrogen cycle metabolic process (GO:0071941)5.30164932
25regulation of vitamin D biosynthetic process (GO:0060556)5.21855988
26regulation of T-helper 1 cell differentiation (GO:0045625)5.20762445
27cysteine metabolic process (GO:0006534)5.17699128
28sulfur amino acid catabolic process (GO:0000098)5.12439777
29regulation of complement activation (GO:0030449)5.07788883
30serine family amino acid catabolic process (GO:0009071)4.99962502
31bile acid metabolic process (GO:0008206)4.95325246
32reverse cholesterol transport (GO:0043691)4.79156993
33aromatic amino acid family metabolic process (GO:0009072)4.76987807
34regulation of triglyceride catabolic process (GO:0010896)4.73043994
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72814725
36homocysteine metabolic process (GO:0050667)4.70482337
37regulation of cytokine secretion involved in immune response (GO:0002739)4.68771186
38plasma lipoprotein particle remodeling (GO:0034369)4.67939416
39protein-lipid complex remodeling (GO:0034368)4.67939416
40macromolecular complex remodeling (GO:0034367)4.67939416
41regulation of cholesterol esterification (GO:0010872)4.67374485
42regulation of chronic inflammatory response (GO:0002676)4.65686794
43regulation of fever generation (GO:0031620)4.63295171
44acylglycerol homeostasis (GO:0055090)4.58279596
45triglyceride homeostasis (GO:0070328)4.58279596
46tyrosine metabolic process (GO:0006570)4.58264232
47phospholipid efflux (GO:0033700)4.56855044
48branching involved in labyrinthine layer morphogenesis (GO:0060670)4.55213184
49negative regulation of sterol transport (GO:0032372)4.54348812
50negative regulation of cholesterol transport (GO:0032375)4.54348812
51amino-acid betaine metabolic process (GO:0006577)4.50539796
52positive regulation of heat generation (GO:0031652)4.50527102
53alpha-amino acid catabolic process (GO:1901606)4.46038977
54lysine catabolic process (GO:0006554)4.36363960
55lysine metabolic process (GO:0006553)4.36363960
56plasma lipoprotein particle clearance (GO:0034381)4.33541418
57glycine metabolic process (GO:0006544)4.32133993
58positive regulation of chemokine biosynthetic process (GO:0045080)4.31795685
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.30589403
60bile acid and bile salt transport (GO:0015721)4.29217069
61regulation of interferon-alpha production (GO:0032647)4.29102352
62imidazole-containing compound metabolic process (GO:0052803)4.27511794
63cholesterol efflux (GO:0033344)4.22245257
64indolalkylamine metabolic process (GO:0006586)4.21559240
65cellular glucuronidation (GO:0052695)4.15338145
66fibrinolysis (GO:0042730)4.14664213
67amine catabolic process (GO:0009310)4.13663422
68cellular biogenic amine catabolic process (GO:0042402)4.13663422
69cellular amino acid catabolic process (GO:0009063)4.06663752
70coenzyme catabolic process (GO:0009109)4.05232587
71cellular ketone body metabolic process (GO:0046950)4.02749203
72glutamate metabolic process (GO:0006536)4.02667301
73serine family amino acid metabolic process (GO:0009069)4.02451588
74dicarboxylic acid biosynthetic process (GO:0043650)3.98841547
75arginine metabolic process (GO:0006525)3.97780036
76benzene-containing compound metabolic process (GO:0042537)3.96869442
77plasma lipoprotein particle assembly (GO:0034377)3.95792097
78ethanol oxidation (GO:0006069)3.95467926
79cellular modified amino acid catabolic process (GO:0042219)3.94892295
80regulation of vitamin metabolic process (GO:0030656)3.94491612
81negative regulation of interleukin-12 production (GO:0032695)3.87635631
82regulation of cholesterol homeostasis (GO:2000188)3.87601181
83low-density lipoprotein particle remodeling (GO:0034374)3.87184891
84serine family amino acid biosynthetic process (GO:0009070)3.84900746
85phospholipid homeostasis (GO:0055091)3.82439641
86positive regulation of lipid catabolic process (GO:0050996)3.79672686
87regulation of chemokine biosynthetic process (GO:0045073)3.79611460
88regulation of heat generation (GO:0031650)3.78448002
89regulation of bile acid biosynthetic process (GO:0070857)3.78364427
90cytolysis (GO:0019835)3.71657565
91positive regulation of triglyceride lipase activity (GO:0061365)3.71332968
92positive regulation of lipoprotein lipase activity (GO:0051006)3.71332968
93aldehyde catabolic process (GO:0046185)3.70940494
94complement activation, classical pathway (GO:0006958)3.70467275
95cholesterol homeostasis (GO:0042632)3.68931704
96complement activation (GO:0006956)3.68453065
97blood coagulation, intrinsic pathway (GO:0007597)3.68123184
98uronic acid metabolic process (GO:0006063)3.66937048
99glucuronate metabolic process (GO:0019585)3.66937048
100protein activation cascade (GO:0072376)3.65652186
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.65463457
102negative regulation of lipase activity (GO:0060192)3.64258133
103sterol homeostasis (GO:0055092)3.63324589
104drug catabolic process (GO:0042737)3.62124864
105very-low-density lipoprotein particle assembly (GO:0034379)3.61413393
106plasma lipoprotein particle organization (GO:0071827)3.58357797
107acute-phase response (GO:0006953)3.56419862
108positive regulation of NF-kappaB import into nucleus (GO:0042346)3.54937461
109positive regulation of interferon-alpha production (GO:0032727)3.54011922
110protein-lipid complex assembly (GO:0065005)3.53881621
111positive regulation of fatty acid beta-oxidation (GO:0032000)3.53664309
112organic acid catabolic process (GO:0016054)3.52464123
113carboxylic acid catabolic process (GO:0046395)3.52464123
114positive regulation of cAMP-mediated signaling (GO:0043950)3.51507144
115cofactor catabolic process (GO:0051187)3.51002915
116positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.49530536
117acetyl-CoA metabolic process (GO:0006084)3.48825477
118regulation of plasminogen activation (GO:0010755)3.45740108
119intestinal cholesterol absorption (GO:0030299)3.45701416
120cellular response to ATP (GO:0071318)3.44624641
121positive regulation of defense response to virus by host (GO:0002230)3.34516698
122regulation of mononuclear cell migration (GO:0071675)3.12492396
123negative regulation of viral genome replication (GO:0045071)3.11819647
124regulation of T-helper 1 type immune response (GO:0002825)3.11088514
125positive regulation of T-helper 1 type immune response (GO:0002827)3.08417240
126regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.07928071
127negative regulation of systemic arterial blood pressure (GO:0003085)3.04005396
128positive regulation of prostaglandin secretion (GO:0032308)3.03354223
129regulation of podosome assembly (GO:0071801)3.01728788
130positive regulation of interferon-beta production (GO:0032728)3.00692193
131cellular response to type I interferon (GO:0071357)2.98215279
132type I interferon signaling pathway (GO:0060337)2.98215279
133regulation of immunoglobulin secretion (GO:0051023)2.95879150
134water-soluble vitamin biosynthetic process (GO:0042364)2.95567511
135response to type I interferon (GO:0034340)2.94656545
136regulation of prostaglandin secretion (GO:0032306)2.93224533
137positive regulation of lymphocyte apoptotic process (GO:0070230)2.89395667
138negative regulation of lipid storage (GO:0010888)2.88171035
139eosinophil chemotaxis (GO:0048245)2.85457458
140response to peptidoglycan (GO:0032494)2.83467094
141response to ATP (GO:0033198)2.82078289
142negative regulation of cytokine production involved in immune response (GO:0002719)2.80859744
143negative regulation of nitric oxide biosynthetic process (GO:0045019)2.80822124
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79161133
145negative regulation of axon extension involved in axon guidance (GO:0048843)2.78120365
146DNA deamination (GO:0045006)2.77919138
147regulation of T-helper cell differentiation (GO:0045622)2.75884009
148positive regulation of nitric oxide biosynthetic process (GO:0045429)2.75207976
149interferon-gamma production (GO:0032609)2.73046457
150vitamin biosynthetic process (GO:0009110)2.72667184
151regulation of membrane protein ectodomain proteolysis (GO:0051043)2.72331654
152regulation of heterotypic cell-cell adhesion (GO:0034114)2.71432166
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71064521
154regulation of nitric oxide biosynthetic process (GO:0045428)2.68874137
155positive regulation of interleukin-1 beta secretion (GO:0050718)2.68614416
156positive regulation of T-helper cell differentiation (GO:0045624)2.68548236
157regulation of interleukin-8 biosynthetic process (GO:0045414)2.68409012
158positive regulation of calcium ion import (GO:0090280)2.67831224
159regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.66659408
160response to interferon-beta (GO:0035456)2.65861022
161regulation of NF-kappaB import into nucleus (GO:0042345)2.61901834
162regulation of interleukin-12 production (GO:0032655)2.61825788
163regulation of interleukin-1 beta secretion (GO:0050706)2.60043653
164positive regulation of acute inflammatory response (GO:0002675)2.57422378
165positive regulation of interleukin-12 production (GO:0032735)2.57260938
166regulation of interferon-gamma biosynthetic process (GO:0045072)2.54824942
167monocyte chemotaxis (GO:0002548)2.54287881
168vasodilation (GO:0042311)2.50352963
169fat-soluble vitamin biosynthetic process (GO:0042362)2.49766857
170positive regulation of interleukin-1 secretion (GO:0050716)2.49401528
171cellular response to exogenous dsRNA (GO:0071360)2.49354833
172positive regulation of chemokine production (GO:0032722)2.49109501
173vitamin D metabolic process (GO:0042359)2.48872420
174eosinophil migration (GO:0072677)2.48524921
175regulation of defense response to virus by host (GO:0050691)2.47197813
176indole-containing compound metabolic process (GO:0042430)2.46011530
177cellular response to lipopolysaccharide (GO:0071222)2.43875356
178positive regulation of natural killer cell differentiation (GO:0032825)2.41450921
179positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.40592453
180T-helper 1 type immune response (GO:0042088)2.40280420
181sphingosine metabolic process (GO:0006670)2.40276010
182platelet dense granule organization (GO:0060155)2.38968825
183cellular response to molecule of bacterial origin (GO:0071219)2.36009651
184regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.35959489
185positive regulation of protein autophosphorylation (GO:0031954)2.35909937
186positive regulation of toll-like receptor signaling pathway (GO:0034123)2.35693869
187defense response to protozoan (GO:0042832)2.34468158
188sulfation (GO:0051923)2.34204163
189positive regulation of interferon-gamma production (GO:0032729)2.33274999
190regulation of vascular endothelial growth factor production (GO:0010574)2.33261863
191regulation of regulatory T cell differentiation (GO:0045589)2.32852580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.13173722
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03887341
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.60930445
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.32670859
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14845101
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.75517852
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51628405
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04141731
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.65413987
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.63661346
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.51900997
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76152883
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65973878
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41798179
15* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34908758
16GBX2_23144817_ChIP-Seq_PC3_Human2.32860638
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.24002561
18ZNF274_21170338_ChIP-Seq_K562_Hela2.23285240
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.19356569
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06245042
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04445428
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4868539
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95888359
24VDR_22108803_ChIP-Seq_LS180_Human1.93348164
25CLOCK_20551151_ChIP-Seq_293T_Human1.91806312
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89277677
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86981223
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86754640
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80496100
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.73573822
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.66877006
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65949993
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63504388
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62191573
35* P300_19829295_ChIP-Seq_ESCs_Human1.58787575
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.58473613
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56379891
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54912308
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54772781
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.53935384
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52801002
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52012077
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49244616
44* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44214601
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42703413
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41335968
47EWS_26573619_Chip-Seq_HEK293_Human1.40990179
48VDR_24787735_ChIP-Seq_THP-1_Human1.40728708
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.40535669
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38922324
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.37179933
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36282568
53* CRX_20693478_ChIP-Seq_RETINA_Mouse1.35460684
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.34891584
55IGF1R_20145208_ChIP-Seq_DFB_Human1.34353513
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34017320
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33273524
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.32040240
59* SOX2_19829295_ChIP-Seq_ESCs_Human1.30231814
60* NANOG_19829295_ChIP-Seq_ESCs_Human1.30231814
61ELK1_19687146_ChIP-ChIP_HELA_Human1.28530089
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26175131
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.25101407
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24671429
65FUS_26573619_Chip-Seq_HEK293_Human1.23580365
66HTT_18923047_ChIP-ChIP_STHdh_Human1.23073817
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21425308
68GATA1_22025678_ChIP-Seq_K562_Human1.20400428
69CDX2_22108803_ChIP-Seq_LS180_Human1.18538394
70* SMAD4_21741376_ChIP-Seq_EPCs_Human1.18495941
71GATA3_26560356_Chip-Seq_TH2_Human1.18160763
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17972871
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17430841
74P53_22387025_ChIP-Seq_ESCs_Mouse1.16621346
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16180738
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14838815
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14054753
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.13944863
79* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13301139
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.12957845
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12816769
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12245731
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12217908
84CBP_20019798_ChIP-Seq_JUKART_Human1.10920564
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10920564
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.10852370
87* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10530418
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10411184
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09656049
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09508631
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08919566
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08358584
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08328707
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08162117
95TP53_18474530_ChIP-ChIP_U2OS_Human1.08156276
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07827591
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07456707
98* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07386958
99TAF15_26573619_Chip-Seq_HEK293_Human1.07256506
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07050052
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06806507
102CJUN_26792858_Chip-Seq_BT549_Human1.06019563
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05753000
104* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03799042
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03692459
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.03537753
107PU1_27457419_Chip-Seq_LIVER_Mouse1.03143062
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02952929
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.02952929
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.02658794
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.02123258
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.01960826
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.01423412
114GATA4_25053715_ChIP-Seq_YYC3_Human1.00740146
115AR_25329375_ChIP-Seq_VCAP_Human1.00726928
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97165503
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95501828
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95142472
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90775733
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87205301
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87097279
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.86959252
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86897016
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85601676
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83808826
126EGR1_19032775_ChIP-ChIP_M12_Human0.81946731
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.81298531
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73111337
129ZNF263_19887448_ChIP-Seq_K562_Human0.72328729
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72026570
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70660631
132FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69948791
133GATA6_25053715_ChIP-Seq_YYC3_Human0.68877650
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68190940
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68177252
136CEBPB_22108803_ChIP-Seq_LS180_Human0.67908378
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.67812813
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67714659
139* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65738591
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65266891
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65266891
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65140401
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.64804238
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64717269
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64561035
146KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63535388
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.63406207
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61446405
149LXR_22292898_ChIP-Seq_THP-1_Human0.58404725
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55467838
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.52186665
152AR_20517297_ChIP-Seq_VCAP_Human0.52173057
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51582785
154RARB_24833708_ChIP-Seq_LIVER_Mouse0.51253169
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50098136
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.49994284
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49948802
158* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.49913472
159SOX2_20726797_ChIP-Seq_SW620_Human0.49646205
160NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49606366
161* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.49156447
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.48017507
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.47497151
164SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.46119949
165BCAT_22108803_ChIP-Seq_LS180_Human0.45876655
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.45360571
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.45299994
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.44385541
169* STAT1_17558387_ChIP-Seq_HELA_Human0.44312539
170GATA2_19941826_ChIP-Seq_K562_Human0.44260776
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.43773752
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.42575315
173RACK7_27058665_Chip-Seq_MCF-7_Human0.41482226
174GATA1_19941827_ChIP-Seq_MEL_Mouse0.41417710
175SOX9_24532713_ChIP-Seq_HFSC_Mouse0.41030213
176CBP_21632823_ChIP-Seq_H3396_Human0.40516067
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40482107
178ERG_21242973_ChIP-ChIP_JURKAT_Human0.39844049
179* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38454119
180* IRF8_27001747_Chip-Seq_BMDM_Mouse0.38007544
181RUNX_20019798_ChIP-Seq_JUKART_Human0.37606049
182GATA1_19941826_ChIP-Seq_K562_Human0.37569347
183NFIB_24661679_ChIP-Seq_LUNG_Mouse0.37507937
184ESET_19884257_ChIP-Seq_ESCs_Mouse0.37236515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.78152567
2MP0005360_urolithiasis7.02760811
3MP0005085_abnormal_gallbladder_physiolo6.21473355
4MP0005365_abnormal_bile_salt5.98554102
5MP0008875_abnormal_xenobiotic_pharmacok4.69751879
6MP0006054_spinal_hemorrhage4.65924220
7MP0003252_abnormal_bile_duct3.81968017
8MP0003806_abnormal_nucleotide_metabolis3.73126157
9MP0003303_peritoneal_inflammation3.44774051
10MP0010329_abnormal_lipoprotein_level3.36496344
11MP0005083_abnormal_biliary_tract3.20197359
12MP0009785_altered_susceptibility_to3.17588342
13MP0009840_abnormal_foam_cell3.09678302
14MP0002148_abnormal_hypersensitivity_rea3.06395060
15MP0005671_abnormal_response_to2.80627098
16MP0003011_delayed_dark_adaptation2.69567526
17MP0001666_abnormal_nutrient_absorption2.66922980
18MP0005332_abnormal_amino_acid2.55016044
19MP0003195_calcinosis2.51525764
20MP0004510_myositis2.47806425
21MP0004019_abnormal_vitamin_homeostasis2.25312037
22MP0001835_abnormal_antigen_presentation2.23301120
23MP0002837_dystrophic_cardiac_calcinosis2.16370830
24MP0000609_abnormal_liver_physiology2.13723167
25MP0005000_abnormal_immune_tolerance2.13372433
26MP0002138_abnormal_hepatobiliary_system2.12108823
27MP0003191_abnormal_cellular_cholesterol2.08545134
28MP0001790_abnormal_immune_system2.02378701
29MP0005387_immune_system_phenotype2.02378701
30MP0002118_abnormal_lipid_homeostasis1.93087657
31MP0002254_reproductive_system_inflammat1.89499143
32MP0005167_abnormal_blood-brain_barrier1.88395158
33MP0001533_abnormal_skeleton_physiology1.88274159
34MP0001764_abnormal_homeostasis1.81707989
35MP0003868_abnormal_feces_composition1.81552576
36MP0002419_abnormal_innate_immunity1.79368131
37MP0005319_abnormal_enzyme/_coenzyme1.72907473
38MP0005025_abnormal_response_to1.71418266
39MP0003646_muscle_fatigue1.62129925
40MP0003705_abnormal_hypodermis_morpholog1.61514143
41MP0003075_altered_response_to1.59069212
42MP0002723_abnormal_immune_serum1.58170622
43MP0008004_abnormal_stomach_pH1.55405224
44MP0001800_abnormal_humoral_immune1.53367409
45MP0002452_abnormal_antigen_presenting1.52238711
46MP0006072_abnormal_retinal_apoptosis1.44948346
47MP0009697_abnormal_copulation1.39473271
48MP0005451_abnormal_body_composition1.37116632
49MP0002332_abnormal_exercise_endurance1.35670523
50MP0005584_abnormal_enzyme/coenzyme_acti1.32220267
51MP0005058_abnormal_lysosome_morphology1.28028272
52MP0000343_altered_response_to1.26894898
53MP0003172_abnormal_lysosome_physiology1.25939389
54MP0002405_respiratory_system_inflammati1.23367478
55MP0009643_abnormal_urine_homeostasis1.22134790
56MP0010368_abnormal_lymphatic_system1.19000283
57MP0000598_abnormal_liver_morphology1.16824432
58MP0005647_abnormal_sex_gland1.16363368
59MP0010155_abnormal_intestine_physiology1.14358284
60MP0001819_abnormal_immune_cell1.13617695
61MP0001542_abnormal_bone_strength1.13616865
62MP0002277_abnormal_respiratory_mucosa1.13444554
63MP0002420_abnormal_adaptive_immunity1.12052890
64MP0002295_abnormal_pulmonary_circulatio1.11950816
65MP0002163_abnormal_gland_morphology1.11936297
66MP0005310_abnormal_salivary_gland1.10289601
67MP0009053_abnormal_anal_canal1.10095733
68MP0009764_decreased_sensitivity_to1.08885036
69MP0003186_abnormal_redox_activity1.08346041
70MP0005379_endocrine/exocrine_gland_phen1.08099118
71MP0005551_abnormal_eye_electrophysiolog1.07966788
72MP0009763_increased_sensitivity_to1.02539911
73MP0002998_abnormal_bone_remodeling0.99362951
74MP0002933_joint_inflammation0.99267730
75MP0003656_abnormal_erythrocyte_physiolo0.98890843
76MP0005595_abnormal_vascular_smooth0.98502008
77MP0001501_abnormal_sleep_pattern0.98304068
78MP0003448_altered_tumor_morphology0.96269601
79MP0000516_abnormal_urinary_system0.92087795
80MP0005367_renal/urinary_system_phenotyp0.92087795
81MP0008469_abnormal_protein_level0.91430003
82MP0000604_amyloidosis0.91214231
83MP0009780_abnormal_chondrocyte_physiolo0.88171104
84MP0005390_skeleton_phenotype0.87490513
85MP0001919_abnormal_reproductive_system0.86939839
86MP0009278_abnormal_bone_marrow0.85238799
87MP0003279_aneurysm0.84640401
88MP0005220_abnormal_exocrine_pancreas0.84481703
89MP0003950_abnormal_plasma_membrane0.82631482
90MP0005389_reproductive_system_phenotype0.81455826
91MP0005397_hematopoietic_system_phenotyp0.79492567
92MP0001545_abnormal_hematopoietic_system0.79492567
93MP0009765_abnormal_xenobiotic_induced0.79292103
94MP0005408_hypopigmentation0.79278965
95MP0002876_abnormal_thyroid_physiology0.78023850
96MP0009642_abnormal_blood_homeostasis0.77871951
97MP0005164_abnormal_response_to0.76998187
98MP0003436_decreased_susceptibility_to0.76404434
99MP0009333_abnormal_splenocyte_physiolog0.74279012
100MP0002693_abnormal_pancreas_physiology0.73212006
101MP0005376_homeostasis/metabolism_phenot0.72910409
102MP0001661_extended_life_span0.72333514
103MP0005636_abnormal_mineral_homeostasis0.72015831
104MP0005084_abnormal_gallbladder_morpholo0.70909705
105MP0005248_abnormal_Harderian_gland0.69476805
106MP0000716_abnormal_immune_system0.69465097
107MP0002653_abnormal_ependyma_morphology0.68870907
108MP0002971_abnormal_brown_adipose0.66635761
109MP0004381_abnormal_hair_follicle0.66429073
110MP0004133_heterotaxia0.66298012
111MP0005334_abnormal_fat_pad0.65489410
112MP0005670_abnormal_white_adipose0.65451620
113MP0001485_abnormal_pinna_reflex0.64388040
114MP0002796_impaired_skin_barrier0.63403740
115MP0000767_abnormal_smooth_muscle0.62772937
116MP0002078_abnormal_glucose_homeostasis0.62672554
117MP0000230_abnormal_systemic_arterial0.62446886
118MP0001756_abnormal_urination0.61972931
119MP0006082_CNS_inflammation0.61215744
120MP0001663_abnormal_digestive_system0.61108252
121MP0000689_abnormal_spleen_morphology0.59149579
122MP0001324_abnormal_eye_pigmentation0.59108776
123MP0004782_abnormal_surfactant_physiolog0.58858056
124MP0000579_abnormal_nail_morphology0.58632701
125MP0005464_abnormal_platelet_physiology0.57149373
126MP0002136_abnormal_kidney_physiology0.55499990
127MP0001853_heart_inflammation0.55077632
128MP0002928_abnormal_bile_duct0.54936469
129MP0002060_abnormal_skin_morphology0.50868602
130MP0003453_abnormal_keratinocyte_physiol0.50824603
131MP0001243_abnormal_dermal_layer0.50812808
132MP0005187_abnormal_penis_morphology0.50660983
133MP0003638_abnormal_response/metabolism_0.50512533
134MP0001881_abnormal_mammary_gland0.49826316
135MP0002090_abnormal_vision0.49115355
136MP0004130_abnormal_muscle_cell0.48101661
137MP0009384_cardiac_valve_regurgitation0.47859425
138MP0010234_abnormal_vibrissa_follicle0.47823102
139MP0000639_abnormal_adrenal_gland0.47751170
140MP0001845_abnormal_inflammatory_respons0.44896168
141MP0005266_abnormal_metabolism0.44252211
142MP0004947_skin_inflammation0.43954960
143MP0005395_other_phenotype0.43859976
144MP0000685_abnormal_immune_system0.43241389
145MP0005253_abnormal_eye_physiology0.41982359
146MP0005166_decreased_susceptibility_to0.41607665
147MP0005535_abnormal_body_temperature0.40860101
148MP0005448_abnormal_energy_balance0.40462175
149MP0003724_increased_susceptibility_to0.39900559
150MP0003690_abnormal_glial_cell0.38656769
151MP0000427_abnormal_hair_cycle0.38502629
152MP0005023_abnormal_wound_healing0.38199686
153MP0003300_gastrointestinal_ulcer0.37194315
154MP0005195_abnormal_posterior_eye0.37108009
155MP0005197_abnormal_uvea_morphology0.36328268
156MP0002168_other_aberrant_phenotype0.36286007
157MP0006036_abnormal_mitochondrial_physio0.35928513
158MP0008873_increased_physiological_sensi0.35763482
159MP0002098_abnormal_vibrissa_morphology0.32752212
160MP0001216_abnormal_epidermal_layer0.32448181
161MP0009115_abnormal_fat_cell0.32351334
162MP0002135_abnormal_kidney_morphology0.32250902
163MP0009672_abnormal_birth_weight0.31616051

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.47418603
2Intrahepatic cholestasis (HP:0001406)7.23595352
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.97445108
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55962885
5Prolonged partial thromboplastin time (HP:0003645)6.54462958
6Hypobetalipoproteinemia (HP:0003563)6.29172577
7Xanthomatosis (HP:0000991)6.22214282
8Complement deficiency (HP:0004431)5.35379164
9Hyperlipoproteinemia (HP:0010980)5.34969628
10Hypolipoproteinemia (HP:0010981)4.79341720
11Joint hemorrhage (HP:0005261)4.69229316
12Abnormality of the common coagulation pathway (HP:0010990)4.62377332
13Epidermoid cyst (HP:0200040)4.46039287
14Hyperammonemia (HP:0001987)4.38255512
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36662360
16Hypoalphalipoproteinemia (HP:0003233)4.24829671
17Hyperglycinemia (HP:0002154)4.21267173
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17582912
19Stomatitis (HP:0010280)4.16219756
20Fat malabsorption (HP:0002630)4.14967810
21Abnormality of methionine metabolism (HP:0010901)4.14332941
22Abnormality of liposaccharide metabolism (HP:0010968)4.13335811
23Abnormality of glycosphingolipid metabolism (HP:0004343)4.13335811
24Abnormality of glycolipid metabolism (HP:0010969)4.13335811
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.13330760
26Optic neuritis (HP:0100653)4.09056569
27Retrobulbar optic neuritis (HP:0100654)4.09056569
28Abnormality of complement system (HP:0005339)4.01779727
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.91798932
30Ketosis (HP:0001946)3.88306242
31Abnormality of the intrinsic pathway (HP:0010989)3.80021574
32Hyperglycinuria (HP:0003108)3.72954704
33Conjugated hyperbilirubinemia (HP:0002908)3.70637914
34Abnormality of serine family amino acid metabolism (HP:0010894)3.64741369
35Abnormality of glycine metabolism (HP:0010895)3.64741369
36Orchitis (HP:0100796)3.64152745
37Hypoglycemic coma (HP:0001325)3.63704152
38Hypercholesterolemia (HP:0003124)3.61069412
39Abnormality of pyrimidine metabolism (HP:0004353)3.60209955
40Pigmentary retinal degeneration (HP:0001146)3.35149003
41Vacuolated lymphocytes (HP:0001922)3.30783085
42Disinhibition (HP:0000734)3.29719909
43Thyroiditis (HP:0100646)3.28654005
44Hematochezia (HP:0002573)3.25169396
45Myocardial infarction (HP:0001658)3.22937670
46Steatorrhea (HP:0002570)3.16122776
47Hyperbilirubinemia (HP:0002904)3.11860874
48Chorioretinal atrophy (HP:0000533)3.11263462
49Myositis (HP:0100614)3.05794886
50Hepatocellular carcinoma (HP:0001402)3.05000249
51Abnormality of fatty-acid metabolism (HP:0004359)3.03351542
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00998727
53Spontaneous abortion (HP:0005268)2.99604830
54Methylmalonic acidemia (HP:0002912)2.95657328
55Abnormality of nucleobase metabolism (HP:0010932)2.91790684
56Hypochromic microcytic anemia (HP:0004840)2.86188383
57Keratoconjunctivitis (HP:0001096)2.85460820
58Parakeratosis (HP:0001036)2.81985536
59Abnormality of serum amino acid levels (HP:0003112)2.78284478
60Vascular calcification (HP:0004934)2.77721634
61Severe combined immunodeficiency (HP:0004430)2.74734257
62Recurrent gram-negative bacterial infections (HP:0005420)2.74071598
63Delayed CNS myelination (HP:0002188)2.74056514
64Mesangial abnormality (HP:0001966)2.73009352
65Systemic lupus erythematosus (HP:0002725)2.72683733
66Abolished electroretinogram (ERG) (HP:0000550)2.68711870
67Glomerulonephritis (HP:0000099)2.68145253
68Skin nodule (HP:0200036)2.67852398
69Intestinal atresia (HP:0011100)2.67301953
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.67030128
71Keratoconjunctivitis sicca (HP:0001097)2.64191892
723-Methylglutaconic aciduria (HP:0003535)2.60764257
73Ketoacidosis (HP:0001993)2.59204118
74B lymphocytopenia (HP:0010976)2.58265792
75Esophageal varix (HP:0002040)2.58224205
76Septo-optic dysplasia (HP:0100842)2.58131298
77Abnormality of purine metabolism (HP:0004352)2.57581049
78Abnormality of B cell number (HP:0010975)2.53617083
79Pancreatic fibrosis (HP:0100732)2.53069652
80Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.52197055
81Acanthocytosis (HP:0001927)2.48514601
82Cardiovascular calcification (HP:0011915)2.47963702
83Combined immunodeficiency (HP:0005387)2.45363166
84True hermaphroditism (HP:0010459)2.42244593
85Pancreatic cysts (HP:0001737)2.39877390
86Metabolic acidosis (HP:0001942)2.39709018
87Hypoplastic pelvis (HP:0008839)2.38568367
88Mitral stenosis (HP:0001718)2.37978469
89Gingival bleeding (HP:0000225)2.36005894
90Short hallux (HP:0010109)2.33611055
91Methylmalonic aciduria (HP:0012120)2.32887807
92Congenital sensorineural hearing impairment (HP:0008527)2.32374824
93Molar tooth sign on MRI (HP:0002419)2.32150478
94Abnormality of midbrain morphology (HP:0002418)2.32150478
95Gout (HP:0001997)2.32110368
96Hypoglycemic seizures (HP:0002173)2.31355717
97Congenital stationary night blindness (HP:0007642)2.30364290
98Abnormality of the phalanges of the 5th finger (HP:0004213)2.30258889
99Spastic diplegia (HP:0001264)2.29243969
100Abnormal gallbladder morphology (HP:0012437)2.28513304
101Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.27693250
102Short 1st metacarpal (HP:0010034)2.27693250
103Lethargy (HP:0001254)2.26314244
104Dysostosis multiplex (HP:0000943)2.25679338
105Inappropriate behavior (HP:0000719)2.25619925
106Thrombophlebitis (HP:0004418)2.25249039
107Cholelithiasis (HP:0001081)2.24400181
108Pulmonary infiltrates (HP:0002113)2.23469711
109Aplasia/Hypoplasia of the hallux (HP:0008362)2.22948692
110Elevated erythrocyte sedimentation rate (HP:0003565)2.21409321
111Agitation (HP:0000713)2.19711565
112T lymphocytopenia (HP:0005403)2.17840172
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17061317
114Dicarboxylic aciduria (HP:0003215)2.17061317
115Vitreoretinal degeneration (HP:0000655)2.16812772
116Abnormality of vitamin B metabolism (HP:0004340)2.15330082
117Irritability (HP:0000737)2.15156091
118Nuclear cataract (HP:0100018)2.14196667
119Autoimmune thrombocytopenia (HP:0001973)2.13962412
120Hypothermia (HP:0002045)2.13876212
121Gangrene (HP:0100758)2.13278116
122Adactyly (HP:0009776)2.13032513
123Malnutrition (HP:0004395)2.12341501
124Pendular nystagmus (HP:0012043)2.12001069
125Neonatal onset (HP:0003623)2.11434019
126Metaphyseal irregularity (HP:0003025)2.11101162
127Nephritis (HP:0000123)2.10417769
128Menorrhagia (HP:0000132)2.08239458
129Abnormality of T cell number (HP:0011839)2.07972588
130Pancreatitis (HP:0001733)2.06589007
131Abnormality of the middle phalanges of the toes (HP:0010183)2.06530101
132Abnormality of polysaccharide metabolism (HP:0011012)2.04325915
133Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04325915
134Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04325915
135Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.04172510
136Short tibia (HP:0005736)2.04135826
137Hydroxyprolinuria (HP:0003080)2.03579268
138Abnormality of proline metabolism (HP:0010907)2.03579268
139Leukocytosis (HP:0001974)2.03128647
140Enlarged kidneys (HP:0000105)2.02602640
141Polyneuropathy (HP:0001271)2.02403541
142Hemorrhage of the eye (HP:0011885)2.01393409
143Mutism (HP:0002300)2.00766732
144Abnormality of macrophages (HP:0004311)2.00219643
145Sensorimotor neuropathy (HP:0007141)1.99966851
146IgG deficiency (HP:0004315)1.99941632
147Short femoral neck (HP:0100864)1.97058369
148Abnormality of vitamin metabolism (HP:0100508)1.96455231
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.95884600
150Recurrent bacterial skin infections (HP:0005406)1.95078276
151Urinary glycosaminoglycan excretion (HP:0003541)1.94645056
152Mucopolysacchariduria (HP:0008155)1.94645056
153Cerebral edema (HP:0002181)1.94569089
154Asplenia (HP:0001746)1.94289174
155Poikilocytosis (HP:0004447)1.94197862
156Amyloidosis (HP:0011034)1.94116255
157Anorexia (HP:0002039)1.93953372
158Abnormal cartilage morphology (HP:0002763)1.92236636
159Abnormality of the 1st metacarpal (HP:0010009)1.91457526
160Albinism (HP:0001022)1.91382878
161Abnormality of eosinophils (HP:0001879)1.89939410
162Rickets (HP:0002748)1.89850908
163Cholecystitis (HP:0001082)1.89705473
164Abnormal gallbladder physiology (HP:0012438)1.89705473
165Abnormality of the costochondral junction (HP:0000919)1.89592053
166Nephronophthisis (HP:0000090)1.88466836
167Renal cortical cysts (HP:0000803)1.88321613
168Hyperglycemia (HP:0003074)1.88004869
169Encephalitis (HP:0002383)1.87808389
170Abnormality of the gallbladder (HP:0005264)1.86540944
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.86398663
172Episodic fever (HP:0001954)1.84374188
173Mesomelia (HP:0003027)1.83708537
174Fused cervical vertebrae (HP:0002949)1.83565854
175Opisthotonus (HP:0002179)1.83041413
176Abnormality of transition element cation homeostasis (HP:0011030)1.82991218
177Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.82580028
178Progressive inability to walk (HP:0002505)1.82284726
179Polyphagia (HP:0002591)1.81921633
180Abnormality of iron homeostasis (HP:0011031)1.81915571
181Brushfield spots (HP:0001088)1.81375432
182Abnormal enzyme/coenzyme activity (HP:0012379)1.80730335
183Autoimmune hemolytic anemia (HP:0001890)1.80519065
184Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78778232
185Late onset (HP:0003584)1.78684510
186Pulmonary embolism (HP:0002204)1.78012327
187Nausea (HP:0002018)1.77268302
188Vomiting (HP:0002013)1.77101947
189Recurrent fungal infections (HP:0002841)1.76882355
190Elevated hepatic transaminases (HP:0002910)1.73295510
191Generalized aminoaciduria (HP:0002909)1.69818824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.02389807
2FGFR44.47724651
3SIK14.07616753
4ERN13.91835262
5ADRBK23.61749728
6ACVR1B3.59387256
7GRK73.47322192
8BMPR1B3.23924143
9WNK32.88800819
10ERBB42.65174682
11MAP4K22.54347618
12TAOK32.43339566
13DDR22.26574198
14MST1R2.24849632
15LATS12.20996935
16INSRR2.19598640
17PBK2.17893914
18PKN22.13828445
19TYK22.13517184
20MAP3K141.98727587
21FRK1.88609244
22MST41.87015506
23TNIK1.86816435
24GRK11.86339473
25TRIB31.83494360
26PTK61.73470610
27MATK1.65875166
28FGFR21.59996409
29NME21.59193572
30KDR1.58833611
31NEK91.58603877
32PLK21.56191409
33FLT31.53267404
34TBK11.51543851
35MAP3K101.51447477
36PIK3CG1.46348642
37BMPR21.45799894
38JAK11.45499315
39MAPK111.43277470
40TRIM281.42218831
41DYRK1B1.39772609
42ERBB31.35651908
43JAK21.35258140
44EIF2AK31.35033797
45MKNK21.34411745
46FGFR31.30026932
47EPHA31.29001651
48MOS1.28097173
49STK38L1.27119311
50MAP3K31.24312848
51MAP2K41.16482630
52MAP3K71.16423993
53FGR1.12857507
54PAK31.11060307
55IKBKE1.05598694
56CDK61.05434322
57ERBB21.04679688
58IRAK41.03036921
59MAP4K10.98675427
60TGFBR20.97262656
61GRK60.96431369
62ZAK0.94440856
63CLK10.94395156
64PRKAA20.94094771
65ABL20.91868679
66CHUK0.89251137
67LYN0.88205380
68ITK0.88140764
69MAP2K30.87324735
70EPHB10.85770956
71KIT0.85360897
72NLK0.82723658
73JAK30.82309170
74CSK0.81627714
75RIPK10.81338054
76MKNK10.81331780
77CAMK1D0.79159402
78GSK3A0.78543717
79MAP2K60.78502946
80IRAK30.77224826
81IRAK20.77052577
82PRKCZ0.76518769
83CSNK1G10.74844189
84MET0.74346073
85MAPK70.74280765
86MAPK120.73866223
87DAPK20.71602490
88MAPK40.71104623
89CSNK1G20.67286114
90PLK30.66808599
91CSNK1G30.66065873
92SGK30.65697194
93SYK0.63807173
94EPHB20.63532076
95PLK40.62173649
96EIF2AK20.61830880
97ZAP700.61356139
98TAOK10.60488953
99EPHA20.59887615
100IKBKB0.58224106
101DYRK30.57966757
102TAF10.57613241
103LCK0.57460923
104PIM20.57026836
105PRKCE0.56605153
106MAP3K40.56389161
107MTOR0.55822942
108CAMKK20.55354810
109STK100.55181079
110PRKCQ0.54987586
111PTK20.54233757
112PRKACG0.54123608
113CDK40.53652277
114TYRO30.52257059
115CDC42BPA0.52071551
116TXK0.51980246
117TIE10.51925567
118FGFR10.51667878
119STK160.51496717
120NUAK10.50961471
121IRAK10.50801479
122SGK20.50587891
123STK30.50510970
124ADRBK10.50203235
125MAP3K50.49329826
126MAP3K110.48469012
127IGF1R0.48242420
128NTRK20.48060560
129PRKAA10.48028209
130PIM10.47168608
131PRKCG0.46961639
132WNK40.46541226
133PINK10.46441660
134INSR0.46364490
135TAOK20.45272269
136MARK30.44693446
137TEC0.44353649
138RPS6KA40.44235131
139BMX0.44081965
140CSNK1A1L0.43542212
141MAPK130.43466548
142FER0.42586760
143TGFBR10.42015153
144LRRK20.41284809
145BLK0.39542453
146TLK10.38789064
147EGFR0.36056221
148PDGFRA0.34246166
149PTK2B0.33138651
150CSF1R0.32489067
151CAMK2G0.31415912
152HCK0.31204958
153CDK80.30745481
154RET0.29433208
155CDK120.28510169
156AKT30.28144106
157ABL10.27565069
158MAPK30.27079768

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55142284
2Nitrogen metabolism_Homo sapiens_hsa009103.75116154
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.66245816
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33379356
5Arginine biosynthesis_Homo sapiens_hsa002203.15789426
6Complement and coagulation cascades_Homo sapiens_hsa046102.89938325
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.69948007
8Rheumatoid arthritis_Homo sapiens_hsa053232.64360511
9Tryptophan metabolism_Homo sapiens_hsa003802.62184110
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54946329
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49514470
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46602933
13Fatty acid degradation_Homo sapiens_hsa000712.40021561
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26916179
15Allograft rejection_Homo sapiens_hsa053302.22586403
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21576764
17Asthma_Homo sapiens_hsa053102.19609710
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.12761659
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09910987
20Malaria_Homo sapiens_hsa051442.09559107
21Graft-versus-host disease_Homo sapiens_hsa053322.06689024
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05111412
23Type I diabetes mellitus_Homo sapiens_hsa049402.02299164
24Peroxisome_Homo sapiens_hsa041461.97702968
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96275392
26Chemical carcinogenesis_Homo sapiens_hsa052041.95799136
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94992599
28Pertussis_Homo sapiens_hsa051331.94614027
29Staphylococcus aureus infection_Homo sapiens_hsa051501.92580362
30Histidine metabolism_Homo sapiens_hsa003401.90770104
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90759344
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.89902737
33Caffeine metabolism_Homo sapiens_hsa002321.89576248
34Butanoate metabolism_Homo sapiens_hsa006501.89171974
35Retinol metabolism_Homo sapiens_hsa008301.87243946
36PPAR signaling pathway_Homo sapiens_hsa033201.82607330
37Propanoate metabolism_Homo sapiens_hsa006401.79166994
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77029631
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.76509673
40Fatty acid metabolism_Homo sapiens_hsa012121.68798728
41Autoimmune thyroid disease_Homo sapiens_hsa053201.68324875
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66004104
43beta-Alanine metabolism_Homo sapiens_hsa004101.64686321
44TNF signaling pathway_Homo sapiens_hsa046681.64038868
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64004282
46Phenylalanine metabolism_Homo sapiens_hsa003601.63861907
47Selenocompound metabolism_Homo sapiens_hsa004501.60700209
48Protein export_Homo sapiens_hsa030601.51640982
49Lysosome_Homo sapiens_hsa041421.46167821
50Primary immunodeficiency_Homo sapiens_hsa053401.45821889
51Osteoclast differentiation_Homo sapiens_hsa043801.44650553
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42876865
53Bile secretion_Homo sapiens_hsa049761.42390099
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40934084
55Tyrosine metabolism_Homo sapiens_hsa003501.39427104
56Other glycan degradation_Homo sapiens_hsa005111.37224977
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33197121
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33179858
59Hematopoietic cell lineage_Homo sapiens_hsa046401.32253632
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31434326
61Fat digestion and absorption_Homo sapiens_hsa049751.27643671
62Leishmaniasis_Homo sapiens_hsa051401.26462604
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.25767713
64Tuberculosis_Homo sapiens_hsa051521.24250377
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23448549
66ABC transporters_Homo sapiens_hsa020101.23422062
67Sulfur metabolism_Homo sapiens_hsa009201.22255895
68Pyruvate metabolism_Homo sapiens_hsa006201.21994350
69Steroid biosynthesis_Homo sapiens_hsa001001.20953909
70Starch and sucrose metabolism_Homo sapiens_hsa005001.19803573
71Folate biosynthesis_Homo sapiens_hsa007901.17756512
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.17749602
73Phototransduction_Homo sapiens_hsa047441.16536001
74Biosynthesis of amino acids_Homo sapiens_hsa012301.15751077
75Fatty acid elongation_Homo sapiens_hsa000621.11117813
76Cyanoamino acid metabolism_Homo sapiens_hsa004601.05311098
77Carbon metabolism_Homo sapiens_hsa012001.00583216
78Maturity onset diabetes of the young_Homo sapiens_hsa049501.00241263
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98161060
80Vitamin digestion and absorption_Homo sapiens_hsa049770.94358458
81Herpes simplex infection_Homo sapiens_hsa051680.93114089
82Measles_Homo sapiens_hsa051620.93005706
83Lysine degradation_Homo sapiens_hsa003100.90643380
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87724959
85Arginine and proline metabolism_Homo sapiens_hsa003300.86298145
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85798656
87Collecting duct acid secretion_Homo sapiens_hsa049660.84300444
88Antigen processing and presentation_Homo sapiens_hsa046120.82499094
89Sulfur relay system_Homo sapiens_hsa041220.81967580
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81916066
91Influenza A_Homo sapiens_hsa051640.81432656
92Mineral absorption_Homo sapiens_hsa049780.81424263
93Sphingolipid metabolism_Homo sapiens_hsa006000.81027493
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77382635
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75430418
96Ether lipid metabolism_Homo sapiens_hsa005650.73963757
97One carbon pool by folate_Homo sapiens_hsa006700.73420474
98Proteasome_Homo sapiens_hsa030500.73003145
99Salmonella infection_Homo sapiens_hsa051320.72675557
100Basal transcription factors_Homo sapiens_hsa030220.72662886
101Glycerolipid metabolism_Homo sapiens_hsa005610.71239591
102Vitamin B6 metabolism_Homo sapiens_hsa007500.70148410
103Oxidative phosphorylation_Homo sapiens_hsa001900.66718266
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63910453
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63224319
106Glutathione metabolism_Homo sapiens_hsa004800.58841612
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57315205
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55429381
109Fatty acid biosynthesis_Homo sapiens_hsa000610.52363230
110Chemokine signaling pathway_Homo sapiens_hsa040620.50844466
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50206482
112Toxoplasmosis_Homo sapiens_hsa051450.49275428
113Pentose phosphate pathway_Homo sapiens_hsa000300.48922994
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48738233
115Dorso-ventral axis formation_Homo sapiens_hsa043200.48095250
116T cell receptor signaling pathway_Homo sapiens_hsa046600.42218327
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40475841
118* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39704234
119Metabolic pathways_Homo sapiens_hsa011000.36148218
120Phagosome_Homo sapiens_hsa041450.34452171
121Prion diseases_Homo sapiens_hsa050200.32183638
122Insulin resistance_Homo sapiens_hsa049310.29666676
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27180298
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.25200218
125Galactose metabolism_Homo sapiens_hsa000520.22120037
126Linoleic acid metabolism_Homo sapiens_hsa005910.21391299
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19101613
128Fructose and mannose metabolism_Homo sapiens_hsa000510.17320595
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.12253389
130Glucagon signaling pathway_Homo sapiens_hsa049220.04521968
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03624317
132AMPK signaling pathway_Homo sapiens_hsa041520.03093969
133Legionellosis_Homo sapiens_hsa05134-0.2071011
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.2037004
135Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1968303
136Renin-angiotensin system_Homo sapiens_hsa04614-0.1888916
137Protein digestion and absorption_Homo sapiens_hsa04974-0.1853697
138Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1827991
139Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1792020
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1733456
141Bladder cancer_Homo sapiens_hsa05219-0.1639481
142African trypanosomiasis_Homo sapiens_hsa05143-0.1600345
143Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1576542
144Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1561608
145NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1528595
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1453838
147Amoebiasis_Homo sapiens_hsa05146-0.1249727
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1224260
149Insulin signaling pathway_Homo sapiens_hsa04910-0.1190111
150Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1086638
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1022485
152Hepatitis C_Homo sapiens_hsa05160-0.0629879

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