HRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.13444597
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.01754505
3vocalization behavior (GO:0071625)5.81531339
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.77167632
5locomotory exploration behavior (GO:0035641)5.66667890
6synaptic vesicle maturation (GO:0016188)5.53557618
7regulation of glutamate receptor signaling pathway (GO:1900449)5.32177913
8synaptic vesicle exocytosis (GO:0016079)5.28644831
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19942335
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.13086175
11neuron cell-cell adhesion (GO:0007158)5.06125601
12protein localization to synapse (GO:0035418)5.03783465
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.97818026
14glutamate secretion (GO:0014047)4.93456960
15regulation of synaptic vesicle exocytosis (GO:2000300)4.77461757
16behavioral response to nicotine (GO:0035095)4.70117558
17regulation of synapse structural plasticity (GO:0051823)4.61531547
18dendritic spine morphogenesis (GO:0060997)4.57245691
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55838169
20regulation of neuronal synaptic plasticity (GO:0048168)4.54916900
21exploration behavior (GO:0035640)4.54498711
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45853976
23synaptic transmission, glutamatergic (GO:0035249)4.45574165
24neurotransmitter-gated ion channel clustering (GO:0072578)4.44212790
25glutamate receptor signaling pathway (GO:0007215)4.39975266
26layer formation in cerebral cortex (GO:0021819)4.30013546
27regulation of synaptic vesicle transport (GO:1902803)4.26532857
28neuron-neuron synaptic transmission (GO:0007270)4.20531595
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.14450803
30neurotransmitter secretion (GO:0007269)4.13395200
31regulation of dendritic spine morphogenesis (GO:0061001)4.04680966
32positive regulation of membrane potential (GO:0045838)4.04627806
33neuron recognition (GO:0008038)3.97539738
34neuronal action potential propagation (GO:0019227)3.97188757
35long-term memory (GO:0007616)3.96675425
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95246712
37regulation of postsynaptic membrane potential (GO:0060078)3.88175492
38respiratory chain complex IV assembly (GO:0008535)3.78641921
39gamma-aminobutyric acid transport (GO:0015812)3.77215899
40regulation of synaptic plasticity (GO:0048167)3.76454975
41axonal fasciculation (GO:0007413)3.76196823
42positive regulation of synapse maturation (GO:0090129)3.75223708
43postsynaptic membrane organization (GO:0001941)3.75178029
44cytochrome complex assembly (GO:0017004)3.74875604
45protein complex biogenesis (GO:0070271)3.74272605
46transmission of nerve impulse (GO:0019226)3.69736600
47positive regulation of neurotransmitter secretion (GO:0001956)3.68930285
48auditory behavior (GO:0031223)3.67789953
49presynaptic membrane assembly (GO:0097105)3.65869726
50proline transport (GO:0015824)3.63463681
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58838067
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.56197170
53water-soluble vitamin biosynthetic process (GO:0042364)3.54807332
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.50890314
55mitochondrial respiratory chain complex assembly (GO:0033108)3.50753936
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47819721
57positive regulation of neurotransmitter transport (GO:0051590)3.47739740
58long-term synaptic potentiation (GO:0060291)3.46879374
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.45432888
60synaptic vesicle endocytosis (GO:0048488)3.45108340
61regulation of dendritic spine development (GO:0060998)3.43275924
62regulation of female receptivity (GO:0045924)3.42724263
63neuromuscular process controlling balance (GO:0050885)3.42616388
64regulation of neurotransmitter secretion (GO:0046928)3.41839585
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.41129484
66neurotransmitter transport (GO:0006836)3.36593167
67presynaptic membrane organization (GO:0097090)3.34945957
68behavioral fear response (GO:0001662)3.34522312
69behavioral defense response (GO:0002209)3.34522312
70dendrite morphogenesis (GO:0048813)3.34261734
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33970228
72nonmotile primary cilium assembly (GO:0035058)3.33454146
73response to auditory stimulus (GO:0010996)3.32371714
74dendritic spine organization (GO:0097061)3.32058359
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.31491740
76NADH dehydrogenase complex assembly (GO:0010257)3.31491740
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31491740
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30843581
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29065977
80positive regulation of dendritic spine development (GO:0060999)3.26892189
81pyrimidine nucleobase catabolic process (GO:0006208)3.26204010
82membrane depolarization (GO:0051899)3.25318352
83activation of protein kinase A activity (GO:0034199)3.25071652
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.24228702
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.24203086
86response to histamine (GO:0034776)3.24121432
87regulation of glutamate secretion (GO:0014048)3.20944857
88regulation of vesicle fusion (GO:0031338)3.20685516
89prepulse inhibition (GO:0060134)3.20268022
90learning (GO:0007612)3.20122055
91synapse assembly (GO:0007416)3.18662482
92female mating behavior (GO:0060180)3.18332467
93regulation of neurotransmitter transport (GO:0051588)3.16589950
94behavioral response to cocaine (GO:0048148)3.16227016
95regulation of cilium movement (GO:0003352)3.13008935
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12857469
97regulation of neurotransmitter levels (GO:0001505)3.12047352
98membrane hyperpolarization (GO:0060081)3.11648329
99fear response (GO:0042596)3.11076563
100vesicle transport along microtubule (GO:0047496)3.07514465
101DNA double-strand break processing (GO:0000729)3.07052847
102neuronal ion channel clustering (GO:0045161)3.04114568
103dopamine receptor signaling pathway (GO:0007212)3.03942495
104adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.03656895
105regulation of synaptic transmission (GO:0050804)3.03500084
106replication fork processing (GO:0031297)3.03382279
107mechanosensory behavior (GO:0007638)3.03104544
108positive regulation of synaptic transmission (GO:0050806)3.02590240
109innervation (GO:0060384)3.01682750
110central nervous system projection neuron axonogenesis (GO:0021952)3.00380712
111regulation of synapse maturation (GO:0090128)2.97521576
112striatum development (GO:0021756)2.96924037
113synaptic transmission (GO:0007268)2.96776772
114membrane depolarization during action potential (GO:0086010)2.96367687
115cellular potassium ion homeostasis (GO:0030007)2.96312913
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94938155
117establishment of protein localization to mitochondrial membrane (GO:0090151)2.94682158
118response to pheromone (GO:0019236)2.93597201
119axoneme assembly (GO:0035082)2.91534094
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89616653
121maturation of 5.8S rRNA (GO:0000460)2.89496169
122chaperone-mediated protein transport (GO:0072321)2.85400112
123regulation of DNA endoreduplication (GO:0032875)2.84286805
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.83997621
125startle response (GO:0001964)2.79289868
126protein polyglutamylation (GO:0018095)2.79221644
127cilium morphogenesis (GO:0060271)2.73371706
128recombinational repair (GO:0000725)2.72799678
129protein K6-linked ubiquitination (GO:0085020)2.70863019
130double-strand break repair via homologous recombination (GO:0000724)2.69957583
131protein K11-linked deubiquitination (GO:0035871)2.69387286
132nucleobase catabolic process (GO:0046113)2.68871006
133regulation of neurotransmitter uptake (GO:0051580)2.68322238
134detection of light stimulus involved in sensory perception (GO:0050962)2.66552659
135detection of light stimulus involved in visual perception (GO:0050908)2.66552659
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61566724
137protein-cofactor linkage (GO:0018065)2.58816462
138retinal ganglion cell axon guidance (GO:0031290)2.57565969
139cilium organization (GO:0044782)2.56790543
140platelet dense granule organization (GO:0060155)2.55506361
141cilium assembly (GO:0042384)2.53608318
142glycerophospholipid catabolic process (GO:0046475)2.47735280
143cell proliferation in forebrain (GO:0021846)2.47607431
144fucose catabolic process (GO:0019317)2.46215245
145L-fucose metabolic process (GO:0042354)2.46215245
146L-fucose catabolic process (GO:0042355)2.46215245
147detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44836155
148L-methionine biosynthetic process (GO:0071265)2.44441063
149amino acid salvage (GO:0043102)2.44441063
150L-methionine salvage (GO:0071267)2.44441063
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43075491
152negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42833538
153negative regulation of translation, ncRNA-mediated (GO:0040033)2.42833538
154regulation of translation, ncRNA-mediated (GO:0045974)2.42833538
155reciprocal DNA recombination (GO:0035825)2.40475245
156reciprocal meiotic recombination (GO:0007131)2.40475245
157synaptic transmission, cholinergic (GO:0007271)2.39869970
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38810267
159cellular response to ATP (GO:0071318)2.38115359
160neuromuscular synaptic transmission (GO:0007274)2.37902841
161inositol phosphate catabolic process (GO:0071545)2.33689488
162indolalkylamine metabolic process (GO:0006586)2.33216640
163exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32538314
164kynurenine metabolic process (GO:0070189)2.32001882
165regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.31411059
166regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.31411059
167regulation of microtubule-based movement (GO:0060632)2.31360146
168C4-dicarboxylate transport (GO:0015740)2.30645938
169negative regulation of telomere maintenance (GO:0032205)2.29757696
170epithelial cilium movement (GO:0003351)2.29278630
171histone H2A acetylation (GO:0043968)2.29076136
172regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.28294556
173neuronal action potential (GO:0019228)2.27943757
174photoreceptor cell maintenance (GO:0045494)2.27676315
175response to misfolded protein (GO:0051788)2.26718576
176intraciliary transport (GO:0042073)2.26431704
177cornea development in camera-type eye (GO:0061303)2.25904350
178anterograde axon cargo transport (GO:0008089)2.25408999
179ubiquinone biosynthetic process (GO:0006744)2.25159692
180epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.24910833
181ubiquinone metabolic process (GO:0006743)2.24797617
182behavioral response to ethanol (GO:0048149)2.24760601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.51169285
2GBX2_23144817_ChIP-Seq_PC3_Human3.60512840
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17078883
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14296825
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03320870
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74789049
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74314962
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74314962
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67603311
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64129993
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.64057929
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.63420343
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57436182
14DROSHA_22980978_ChIP-Seq_HELA_Human2.49386941
15VDR_22108803_ChIP-Seq_LS180_Human2.49277271
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48701967
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46810229
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44662369
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40731943
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.36223933
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33817927
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31834085
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29469938
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26217918
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22760528
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21415603
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18988977
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.16722039
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.15342783
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.13742749
31EWS_26573619_Chip-Seq_HEK293_Human2.13511146
32IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10690097
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03657443
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93714402
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93489487
36AR_21572438_ChIP-Seq_LNCaP_Human1.84347021
37TAF15_26573619_Chip-Seq_HEK293_Human1.79343344
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79050825
39* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75089380
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.74238827
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72515990
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.69958352
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68723827
44MYC_18940864_ChIP-ChIP_HL60_Human1.67196239
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61533170
46SMAD4_21799915_ChIP-Seq_A2780_Human1.60769393
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.56829164
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56288254
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.53964192
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53951418
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.53313450
52TP53_22573176_ChIP-Seq_HFKS_Human1.51556613
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49716626
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48649447
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46821318
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44498926
57P300_19829295_ChIP-Seq_ESCs_Human1.43810262
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41460022
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.40726183
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39492808
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38566786
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38291915
63* CBX2_27304074_Chip-Seq_ESCs_Mouse1.37570096
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37411350
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35449687
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.34700764
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32297960
68ELK1_19687146_ChIP-ChIP_HELA_Human1.31405365
69* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30130073
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.29222934
71VDR_23849224_ChIP-Seq_CD4+_Human1.28314364
72ZNF274_21170338_ChIP-Seq_K562_Hela1.27200650
73* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26500000
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24496776
75CBP_20019798_ChIP-Seq_JUKART_Human1.22323153
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22323153
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.21393362
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21063102
79AR_25329375_ChIP-Seq_VCAP_Human1.20704087
80IRF1_19129219_ChIP-ChIP_H3396_Human1.20198989
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20178425
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19883395
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19857467
84RNF2_27304074_Chip-Seq_NSC_Mouse1.19828455
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19620018
86STAT3_23295773_ChIP-Seq_U87_Human1.19154909
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17009665
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14960477
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13872864
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13858738
91AR_19668381_ChIP-Seq_PC3_Human1.13789282
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13184192
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12643789
94IGF1R_20145208_ChIP-Seq_DFB_Human1.12428475
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12210128
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11826222
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.11600146
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10078055
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09171951
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09053320
101TCF4_23295773_ChIP-Seq_U87_Human1.06896668
102BCAT_22108803_ChIP-Seq_LS180_Human1.06440119
103NANOG_19829295_ChIP-Seq_ESCs_Human1.06024789
104SOX2_19829295_ChIP-Seq_ESCs_Human1.06024789
105FOXP3_21729870_ChIP-Seq_TREG_Human1.05140091
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04763419
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.04082203
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03874552
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03379557
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.02850945
111FUS_26573619_Chip-Seq_HEK293_Human1.02281163
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01481757
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01040380
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01010792
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00251893
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.00251893
117RUNX2_22187159_ChIP-Seq_PCA_Human0.99920242
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.98728338
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98622762
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98622762
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98435892
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98225128
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97450678
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96964767
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96268042
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95992829
127* TCF4_22108803_ChIP-Seq_LS180_Human0.95492442
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.94682342
129* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94524186
130NCOR_22424771_ChIP-Seq_293T_Human0.94247084
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.93023258
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92878545
133* KDM2B_26808549_Chip-Seq_K562_Human0.92627382
134AHR_22903824_ChIP-Seq_MCF-7_Human0.92466182
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.92346381
136* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92093718
137JUN_21703547_ChIP-Seq_K562_Human0.91881210
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.91848547
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91354024
140CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91134495
141* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90953263
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90710445
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90656931
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.90594894
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90013116
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89811961
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.89787881
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89481720
149ER_23166858_ChIP-Seq_MCF-7_Human0.88426557
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87535361
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85369119
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84994298
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83768981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.66594166
2MP0003880_abnormal_central_pattern5.09513982
3MP0003635_abnormal_synaptic_transmissio4.19749453
4MP0004270_analgesia3.75132368
5MP0002822_catalepsy3.51568699
6MP0009745_abnormal_behavioral_response3.49704599
7MP0002063_abnormal_learning/memory/cond3.44628152
8MP0005423_abnormal_somatic_nervous3.42110202
9MP0002064_seizures3.10908887
10MP0001968_abnormal_touch/_nociception2.93757856
11MP0003136_yellow_coat_color2.93668867
12MP0002572_abnormal_emotion/affect_behav2.86391865
13MP0009046_muscle_twitch2.80135091
14MP0008877_abnormal_DNA_methylation2.76163836
15MP0003646_muscle_fatigue2.67765587
16MP0001486_abnormal_startle_reflex2.64854826
17MP0002734_abnormal_mechanical_nocicepti2.60499750
18MP0002272_abnormal_nervous_system2.53669541
19MP0002736_abnormal_nociception_after2.28942821
20MP0002735_abnormal_chemical_nociception2.22853594
21MP0001440_abnormal_grooming_behavior2.22480928
22MP0001501_abnormal_sleep_pattern2.18729440
23MP0001984_abnormal_olfaction2.17885882
24MP0002653_abnormal_ependyma_morphology2.08293526
25MP0000778_abnormal_nervous_system2.07083245
26MP0002184_abnormal_innervation1.94023894
27MP0002733_abnormal_thermal_nociception1.91273825
28MP0001970_abnormal_pain_threshold1.89996788
29MP0002067_abnormal_sensory_capabilities1.89033394
30MP0002557_abnormal_social/conspecific_i1.83316250
31MP0009780_abnormal_chondrocyte_physiolo1.75464639
32MP0005386_behavior/neurological_phenoty1.75179215
33MP0004924_abnormal_behavior1.75179215
34MP0000372_irregular_coat_pigmentation1.74297253
35* MP0004811_abnormal_neuron_physiology1.73800618
36MP0008569_lethality_at_weaning1.70119048
37MP0003879_abnormal_hair_cell1.68614222
38MP0005645_abnormal_hypothalamus_physiol1.66712498
39MP0001529_abnormal_vocalization1.64036008
40MP0002160_abnormal_reproductive_system1.63261186
41MP0006276_abnormal_autonomic_nervous1.62741387
42MP0004858_abnormal_nervous_system1.60895957
43MP0000955_abnormal_spinal_cord1.58332310
44MP0006072_abnormal_retinal_apoptosis1.57868383
45MP0003329_amyloid_beta_deposits1.57418553
46MP0002909_abnormal_adrenal_gland1.56264301
47MP0005646_abnormal_pituitary_gland1.55028044
48MP0008057_abnormal_DNA_replication1.54751602
49MP0005253_abnormal_eye_physiology1.54513305
50MP0004885_abnormal_endolymph1.48065898
51MP0002882_abnormal_neuron_morphology1.47589825
52MP0001986_abnormal_taste_sensitivity1.46660280
53MP0003787_abnormal_imprinting1.45369215
54MP0002938_white_spotting1.45107626
55MP0000569_abnormal_digit_pigmentation1.44969402
56MP0008058_abnormal_DNA_repair1.42104892
57MP0002066_abnormal_motor_capabilities/c1.38699284
58MP0001188_hyperpigmentation1.37859230
59MP0002095_abnormal_skin_pigmentation1.35036094
60MP0004133_heterotaxia1.30993881
61MP0003121_genomic_imprinting1.30516557
62MP0005389_reproductive_system_phenotype1.29666611
63MP0006292_abnormal_olfactory_placode1.29016313
64MP0005174_abnormal_tail_pigmentation1.28577204
65MP0003195_calcinosis1.26783172
66MP0001905_abnormal_dopamine_level1.26091796
67MP0010094_abnormal_chromosome_stability1.25349390
68MP0005499_abnormal_olfactory_system1.23453778
69MP0005394_taste/olfaction_phenotype1.23453778
70MP0001502_abnormal_circadian_rhythm1.20906489
71MP0002152_abnormal_brain_morphology1.19046375
72MP0003633_abnormal_nervous_system1.17480715
73MP0003011_delayed_dark_adaptation1.14369137
74MP0004142_abnormal_muscle_tone1.14266632
75MP0008995_early_reproductive_senescence1.12651801
76MP0002163_abnormal_gland_morphology1.11326232
77MP0004742_abnormal_vestibular_system1.03545642
78* MP0002751_abnormal_autonomic_nervous1.03522963
79MP0003631_nervous_system_phenotype1.02854548
80MP0001324_abnormal_eye_pigmentation1.01622966
81MP0001177_atelectasis0.96568704
82MP0008874_decreased_physiological_sensi0.96070670
83MP0000015_abnormal_ear_pigmentation0.95637316
84MP0001485_abnormal_pinna_reflex0.95396891
85MP0002069_abnormal_eating/drinking_beha0.95143898
86MP0005409_darkened_coat_color0.94871522
87MP0002928_abnormal_bile_duct0.93831036
88MP0001293_anophthalmia0.92317457
89MP0005195_abnormal_posterior_eye0.92214514
90MP0008872_abnormal_physiological_respon0.92077788
91MP0004043_abnormal_pH_regulation0.91760015
92MP0000427_abnormal_hair_cycle0.90995851
93MP0005075_abnormal_melanosome_morpholog0.89444933
94MP0001963_abnormal_hearing_physiology0.88565096
95MP0001919_abnormal_reproductive_system0.88185861
96MP0002229_neurodegeneration0.87822229
97MP0000631_abnormal_neuroendocrine_gland0.87801159
98MP0003698_abnormal_male_reproductive0.86652506
99MP0003693_abnormal_embryo_hatching0.85988483
100* MP0002752_abnormal_somatic_nervous0.85078768
101MP0003122_maternal_imprinting0.85026777
102MP0002210_abnormal_sex_determination0.84229244
103MP0003890_abnormal_embryonic-extraembry0.84117045
104MP0005551_abnormal_eye_electrophysiolog0.83759806
105MP0003123_paternal_imprinting0.83302814
106MP0001929_abnormal_gametogenesis0.82463937
107MP0004085_abnormal_heartbeat0.82363018
108MP0003718_maternal_effect0.82301294
109MP0005379_endocrine/exocrine_gland_phen0.81648569
110MP0003634_abnormal_glial_cell0.80971166
111MP0003075_altered_response_to0.80882962
112MP0003786_premature_aging0.80131311
113MP0000751_myopathy0.79525738
114MP0003690_abnormal_glial_cell0.73913354
115MP0003632_abnormal_nervous_system0.73397745
116MP0010234_abnormal_vibrissa_follicle0.73013361
117MP0002102_abnormal_ear_morphology0.70386418
118MP0003861_abnormal_nervous_system0.70241718
119MP0000920_abnormal_myelination0.68305422
120MP0010386_abnormal_urinary_bladder0.65786365
121MP0001664_abnormal_digestion0.65232564
122MP0005623_abnormal_meninges_morphology0.64350454
123MP0005535_abnormal_body_temperature0.64209104
124MP0002090_abnormal_vision0.64090503
125MP0003137_abnormal_impulse_conducting0.63445169
126MP0000026_abnormal_inner_ear0.62083858
127MP0000604_amyloidosis0.61993656
128MP0004145_abnormal_muscle_electrophysio0.61852648
129MP0003283_abnormal_digestive_organ0.61765892
130MP0008789_abnormal_olfactory_epithelium0.60941251
131MP0002876_abnormal_thyroid_physiology0.59978256
132MP0005167_abnormal_blood-brain_barrier0.57512491
133MP0004484_altered_response_of0.57474876
134MP0002638_abnormal_pupillary_reflex0.55492204
135MP0004510_myositis0.54966295
136MP0001943_abnormal_respiration0.53423321
137MP0005171_absent_coat_pigmentation0.53258439
138MP0005187_abnormal_penis_morphology0.52533305
139MP0010769_abnormal_survival0.52314601
140MP0002837_dystrophic_cardiac_calcinosis0.52297706
141MP0004215_abnormal_myocardial_fiber0.51709903
142MP0010770_preweaning_lethality0.50577072
143MP0002082_postnatal_lethality0.50577072

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.03601024
2Myokymia (HP:0002411)7.50976226
3Focal seizures (HP:0007359)5.77151382
4Visual hallucinations (HP:0002367)5.10647668
5Epileptic encephalopathy (HP:0200134)4.91765443
6Febrile seizures (HP:0002373)4.50275392
7Atonic seizures (HP:0010819)4.39052411
8Pancreatic cysts (HP:0001737)4.09180409
9Absence seizures (HP:0002121)4.06028671
10Progressive cerebellar ataxia (HP:0002073)3.95854105
11Pancreatic fibrosis (HP:0100732)3.87982903
12Dialeptic seizures (HP:0011146)3.85596077
13Broad-based gait (HP:0002136)3.83476946
14Hyperventilation (HP:0002883)3.80409339
15Generalized tonic-clonic seizures (HP:0002069)3.79678883
16True hermaphroditism (HP:0010459)3.78497083
17Molar tooth sign on MRI (HP:0002419)3.77472746
18Abnormality of midbrain morphology (HP:0002418)3.77472746
19Impaired vibration sensation in the lower limbs (HP:0002166)3.46285459
20Nephronophthisis (HP:0000090)3.42208037
21Ankle clonus (HP:0011448)3.41309418
22Medial flaring of the eyebrow (HP:0010747)3.41261868
23Action tremor (HP:0002345)3.32167760
24Amblyopia (HP:0000646)3.30335607
25Poor eye contact (HP:0000817)3.28690578
26Supranuclear gaze palsy (HP:0000605)3.26002313
27Gaze-evoked nystagmus (HP:0000640)3.16206296
28Depression (HP:0000716)3.12295288
29Chronic hepatic failure (HP:0100626)3.07450753
30Dysmetria (HP:0001310)3.02586260
31Anxiety (HP:0000739)3.02505635
32Mutism (HP:0002300)3.02394851
33Urinary bladder sphincter dysfunction (HP:0002839)3.00382942
34Drooling (HP:0002307)2.99916709
35Excessive salivation (HP:0003781)2.99916709
36Congenital stationary night blindness (HP:0007642)2.96034715
37Dysdiadochokinesis (HP:0002075)2.93982959
38Abnormal social behavior (HP:0012433)2.89845395
39Impaired social interactions (HP:0000735)2.89845395
40Congenital primary aphakia (HP:0007707)2.86671992
41Abnormal eating behavior (HP:0100738)2.80873441
42Progressive inability to walk (HP:0002505)2.78285674
43Abnormality of the renal medulla (HP:0100957)2.76431443
44Type II lissencephaly (HP:0007260)2.75956935
45Torticollis (HP:0000473)2.74613540
46Truncal ataxia (HP:0002078)2.72790004
47Absent speech (HP:0001344)2.72656169
48Papilledema (HP:0001085)2.72480333
49Genetic anticipation (HP:0003743)2.66080985
50Nephrogenic diabetes insipidus (HP:0009806)2.62831211
51Urinary urgency (HP:0000012)2.61717580
52Abnormality of the lower motor neuron (HP:0002366)2.59690893
53Focal dystonia (HP:0004373)2.59140015
54Scanning speech (HP:0002168)2.58485770
55Postural instability (HP:0002172)2.58078894
56Spastic gait (HP:0002064)2.56602307
57Stereotypic behavior (HP:0000733)2.55913934
58Fetal akinesia sequence (HP:0001989)2.55741931
59Impaired smooth pursuit (HP:0007772)2.53082853
60Limb dystonia (HP:0002451)2.50562939
61Cerebral inclusion bodies (HP:0100314)2.49958243
62Epileptiform EEG discharges (HP:0011182)2.48955251
63Absent/shortened dynein arms (HP:0200106)2.48614291
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.48614291
65Anencephaly (HP:0002323)2.42925907
66Genital tract atresia (HP:0001827)2.42170258
67Vaginal atresia (HP:0000148)2.41027971
68Increased hepatocellular lipid droplets (HP:0006565)2.41006649
69Cystic liver disease (HP:0006706)2.40587405
70Neurofibrillary tangles (HP:0002185)2.40106707
71Poor coordination (HP:0002370)2.38674271
72Pendular nystagmus (HP:0012043)2.38661726
73Sclerocornea (HP:0000647)2.38213942
74Abnormality of the corticospinal tract (HP:0002492)2.37748861
75Hemiparesis (HP:0001269)2.37263933
76Diplopia (HP:0000651)2.34914758
77Abnormality of binocular vision (HP:0011514)2.34914758
78EEG with generalized epileptiform discharges (HP:0011198)2.33670033
79Abnormal biliary tract physiology (HP:0012439)2.32736801
80Bile duct proliferation (HP:0001408)2.32736801
81Impaired vibratory sensation (HP:0002495)2.31758593
82Insidious onset (HP:0003587)2.31754586
83Termporal pattern (HP:0011008)2.31754586
84Aplasia/Hypoplasia of the tongue (HP:0010295)2.31457857
85Megalencephaly (HP:0001355)2.30667124
86Inability to walk (HP:0002540)2.30653580
87Lipid accumulation in hepatocytes (HP:0006561)2.30443589
88Bradykinesia (HP:0002067)2.30263375
89Craniofacial dystonia (HP:0012179)2.27317512
90Acute necrotizing encephalopathy (HP:0006965)2.26498997
91Abnormal ciliary motility (HP:0012262)2.24801960
92Mitochondrial inheritance (HP:0001427)2.24573219
93Increased CSF lactate (HP:0002490)2.23661479
94Furrowed tongue (HP:0000221)2.23142549
95Intention tremor (HP:0002080)2.23061922
96Decreased central vision (HP:0007663)2.22486543
97Hypsarrhythmia (HP:0002521)2.21617586
98Annular pancreas (HP:0001734)2.21267718
99Generalized myoclonic seizures (HP:0002123)2.18785388
100Protruding tongue (HP:0010808)2.17725513
101Polyphagia (HP:0002591)2.16797042
102Lissencephaly (HP:0001339)2.14541473
103Abolished electroretinogram (ERG) (HP:0000550)2.14165003
104Abnormality of ocular smooth pursuit (HP:0000617)2.13049136
105Lower limb muscle weakness (HP:0007340)2.12908236
106Obstructive sleep apnea (HP:0002870)2.11765693
107Asplenia (HP:0001746)2.09422854
108Abnormal respiratory motile cilium physiology (HP:0012261)2.08604563
109Progressive macrocephaly (HP:0004481)2.08520716
110Large for gestational age (HP:0001520)2.08186784
111Aplasia/Hypoplasia of the spleen (HP:0010451)2.07163831
112Attenuation of retinal blood vessels (HP:0007843)2.06564013
113Inappropriate behavior (HP:0000719)2.05937698
114Hepatocellular necrosis (HP:0001404)2.05864404
115Abnormal rod and cone electroretinograms (HP:0008323)2.05181629
116Akinesia (HP:0002304)2.04772307
117Abnormality of salivation (HP:0100755)2.04538801
118Abnormal mitochondria in muscle tissue (HP:0008316)2.04011289
119Abnormality of alanine metabolism (HP:0010916)2.03793934
120Hyperalaninemia (HP:0003348)2.03793934
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03793934
122Occipital encephalocele (HP:0002085)2.03577726
123Abnormality of the renal cortex (HP:0011035)2.03575669
124Retinal dysplasia (HP:0007973)2.03393964
125Male pseudohermaphroditism (HP:0000037)2.01686972
1263-Methylglutaconic aciduria (HP:0003535)2.01413224
127Preaxial hand polydactyly (HP:0001177)2.01392187
128Status epilepticus (HP:0002133)2.00057506
129Postaxial foot polydactyly (HP:0001830)2.00027383
130Blue irides (HP:0000635)1.99654351
131Incomplete penetrance (HP:0003829)1.98944105
132Optic nerve hypoplasia (HP:0000609)1.98426313
133Amyotrophic lateral sclerosis (HP:0007354)1.97522771
134Oligodactyly (hands) (HP:0001180)1.95924464
135Pointed chin (HP:0000307)1.95816122
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94308664
137Acute encephalopathy (HP:0006846)1.93898020
138Gait imbalance (HP:0002141)1.93225568
139Abnormality of the labia minora (HP:0012880)1.92151281
140Ankyloglossia (HP:0010296)1.90684673
141Ventricular fibrillation (HP:0001663)1.89515787
142Dysmetric saccades (HP:0000641)1.88961778
143Postaxial hand polydactyly (HP:0001162)1.88702815
144Aganglionic megacolon (HP:0002251)1.86922587
145Hepatic necrosis (HP:0002605)1.86649272
146Abnormality of the ileum (HP:0001549)1.86263504
147Lower limb amyotrophy (HP:0007210)1.85434927
148Optic nerve coloboma (HP:0000588)1.85268792
149Renal Fanconi syndrome (HP:0001994)1.85055579
150Agitation (HP:0000713)1.84978959
151Intestinal atresia (HP:0011100)1.84877786
152Hemiplegia (HP:0002301)1.84712288
153Cerebellar dysplasia (HP:0007033)1.84586123
154Abnormal respiratory epithelium morphology (HP:0012253)1.84362335
155Abnormal respiratory motile cilium morphology (HP:0005938)1.84362335
156Abnormal EKG (HP:0003115)1.84348222
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.84244844
158Abnormal drinking behavior (HP:0030082)1.84182653
159Polydipsia (HP:0001959)1.84182653
160Specific learning disability (HP:0001328)1.83232819
161Narrow forehead (HP:0000341)1.82649264
162Methylmalonic acidemia (HP:0002912)1.82613474
163Anosmia (HP:0000458)1.82575528
164Insomnia (HP:0100785)1.82216850
165Pachygyria (HP:0001302)1.79802031
166Gait ataxia (HP:0002066)1.79625160
167Concave nail (HP:0001598)1.79188751
168Meckel diverticulum (HP:0002245)1.78297164
169Dandy-Walker malformation (HP:0001305)1.78022730
170Congenital hepatic fibrosis (HP:0002612)1.77726288
171Delusions (HP:0000746)1.76319401
172Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76036973
173Methylmalonic aciduria (HP:0012120)1.74183452
174Broad foot (HP:0001769)1.73520354
175Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73041140
176Prominent nasal bridge (HP:0000426)1.71440895
177Increased serum lactate (HP:0002151)1.71310938
178Oculomotor apraxia (HP:0000657)1.70655349
179Multicystic kidney dysplasia (HP:0000003)1.65445042
180Chorioretinal coloboma (HP:0000567)1.65434479
181Tubular atrophy (HP:0000092)1.65418272
182Septo-optic dysplasia (HP:0100842)1.64628763
183Abnormality of DNA repair (HP:0003254)1.64418812
184Astigmatism (HP:0000483)1.62143276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.17476224
2NTRK34.35981818
3FRK4.04398287
4MAP3K93.56000278
5MARK13.54766019
6BMPR1B2.97454790
7MAP3K42.89968230
8DAPK22.84770350
9MINK12.60244228
10CASK2.42823528
11MAP2K72.42256853
12WNK32.28494510
13NTRK22.24829288
14MAP4K22.14382953
15ADRBK22.13615009
16WNK42.10352416
17PINK12.07545428
18PRPF4B2.00645002
19KSR22.00054983
20PAK61.97236039
21ZAK1.93779987
22BRSK21.88907120
23TNIK1.88862149
24CAMKK11.78395848
25KSR11.77272201
26DAPK11.75850790
27TLK11.69567996
28EIF2AK31.69042712
29MAP2K41.68861373
30SIK21.68847735
31GRK11.64433094
32NTRK11.64268471
33PRKD31.62655588
34CDK51.57998499
35MAP3K121.57635446
36DYRK21.56022976
37RIPK41.53765853
38MAPK131.50001210
39PLK21.44701922
40CDK191.44362105
41MKNK21.44168380
42TRIM281.43496687
43ARAF1.37674880
44TSSK61.34046359
45NUAK11.31727674
46STK391.31180089
47FES1.30459324
48PNCK1.26036155
49PLK31.24430426
50PHKG21.22483831
51PHKG11.22483831
52MAP3K21.21522734
53GRK51.20200053
54PRKCG1.19416592
55TYRO31.13361537
56SRPK11.10997388
57MARK31.07547484
58CHEK21.06725769
59CAMK2A1.06177619
60MAP3K131.05172224
61CAMK2B1.02960123
62CSNK1G10.99675857
63UHMK10.99656481
64INSRR0.99648572
65BCKDK0.99051831
66FGFR20.98937388
67CAMKK20.98915715
68TAOK30.97324552
69BRD40.95178735
70STK380.94090692
71SGK4940.93577810
72SGK2230.93577810
73CAMK10.89557498
74RAF10.89405833
75CSNK1G20.89298311
76ATR0.88012867
77STK110.87833774
78BMPR20.86177967
79LATS20.84898727
80CDK180.84509070
81MARK20.84088534
82PTK2B0.83268253
83BRSK10.83267094
84WEE10.83021013
85CDK150.82875373
86SGK20.81867769
87CDK140.81862563
88MAPKAPK50.81747576
89TGFBR10.80527802
90PLK10.79947185
91DYRK1A0.79815337
92OXSR10.79117531
93VRK10.79097284
94STK160.79034227
95CDC70.75303250
96CDK11A0.74104779
97PASK0.72017337
98DYRK30.71688197
99BUB10.70754170
100PAK30.69830063
101SGK10.69554714
102CAMK1D0.69397311
103ATM0.66644460
104MKNK10.66436175
105TAOK10.66376342
106TAF10.64694474
107RET0.64422041
108ERBB30.63032545
109TXK0.62520016
110MAP2K60.61632988
111MAPK150.60692942
112MAP3K100.60299696
113SGK30.59620422
114ACVR1B0.58703198
115CAMK1G0.58179314
116ALK0.57558419
117FGR0.56991714
118PRKCH0.56085054
119CAMK2D0.55617866
120PLK40.54915389
121VRK20.54444675
122CDK30.54439242
123CDK80.54420764
124ADRBK10.54095403
125PDK10.53461557
126PRKCZ0.53154518
127PRKCE0.51292037
128AURKA0.51278133
129CSNK1A10.48685185
130FYN0.48508130
131MAP3K60.48449205
132CSNK1D0.48153383
133PDPK10.47658960
134CAMK40.46293151
135CAMK2G0.46039795
136PRKCI0.45839966
137MST40.45783394
138NME10.45686992
139RPS6KA50.45482440
140CCNB10.45481904
141LMTK20.45314627
142DAPK30.45073421
143RPS6KA30.44688773
144NEK60.43757072
145FER0.42317854
146MUSK0.41542212
147MAPK100.41206580
148SIK30.35782152
149MAPK120.35496990
150CSNK1G30.35001041
151TNK20.34813677
152MAP3K10.34652298
153MAP2K10.33760059
154RPS6KA20.32950293
155CSNK1A1L0.31944822
156AKT30.31635392
157BRAF0.31595304
158BCR0.31479865
159PKN10.30862403
160PRKCB0.30260336
161MAP3K70.30081594

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82251983
2Olfactory transduction_Homo sapiens_hsa047403.44400247
3Synaptic vesicle cycle_Homo sapiens_hsa047213.21896042
4Circadian entrainment_Homo sapiens_hsa047132.81276833
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74716608
6Long-term potentiation_Homo sapiens_hsa047202.73443555
7Glutamatergic synapse_Homo sapiens_hsa047242.72134707
8GABAergic synapse_Homo sapiens_hsa047272.70023409
9Morphine addiction_Homo sapiens_hsa050322.66988144
10Amphetamine addiction_Homo sapiens_hsa050312.61056400
11Oxidative phosphorylation_Homo sapiens_hsa001902.47385678
12Homologous recombination_Homo sapiens_hsa034402.47059202
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37736448
14Selenocompound metabolism_Homo sapiens_hsa004502.31377798
15Fanconi anemia pathway_Homo sapiens_hsa034602.28636059
16Dopaminergic synapse_Homo sapiens_hsa047282.27929922
17RNA polymerase_Homo sapiens_hsa030202.17862263
18Salivary secretion_Homo sapiens_hsa049702.08148561
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07336329
20Non-homologous end-joining_Homo sapiens_hsa034502.05854116
21Parkinsons disease_Homo sapiens_hsa050122.05800582
22Cholinergic synapse_Homo sapiens_hsa047252.02346706
23Butanoate metabolism_Homo sapiens_hsa006501.93387321
24Basal transcription factors_Homo sapiens_hsa030221.90728714
25Insulin secretion_Homo sapiens_hsa049111.90098790
26Taste transduction_Homo sapiens_hsa047421.89297892
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88458530
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86357024
29Gastric acid secretion_Homo sapiens_hsa049711.85029268
30Cocaine addiction_Homo sapiens_hsa050301.82412467
31Protein export_Homo sapiens_hsa030601.81847923
32Serotonergic synapse_Homo sapiens_hsa047261.75248544
33Renin secretion_Homo sapiens_hsa049241.74694891
34Long-term depression_Homo sapiens_hsa047301.74031733
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72468158
36RNA degradation_Homo sapiens_hsa030181.70166231
37Calcium signaling pathway_Homo sapiens_hsa040201.69856569
38Oxytocin signaling pathway_Homo sapiens_hsa049211.69833839
39One carbon pool by folate_Homo sapiens_hsa006701.61358389
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59804044
41Linoleic acid metabolism_Homo sapiens_hsa005911.57361081
42GnRH signaling pathway_Homo sapiens_hsa049121.53501584
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.52854081
44Collecting duct acid secretion_Homo sapiens_hsa049661.51866344
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46093510
46Vitamin B6 metabolism_Homo sapiens_hsa007501.45147554
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45070391
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44131083
49Huntingtons disease_Homo sapiens_hsa050161.43219342
50Gap junction_Homo sapiens_hsa045401.42825775
51Axon guidance_Homo sapiens_hsa043601.36470856
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35787173
53DNA replication_Homo sapiens_hsa030301.34779094
54cAMP signaling pathway_Homo sapiens_hsa040241.32550851
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27671879
56Ether lipid metabolism_Homo sapiens_hsa005651.27415954
57Caffeine metabolism_Homo sapiens_hsa002321.23597473
58Regulation of autophagy_Homo sapiens_hsa041401.20888382
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19252167
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17018100
61RNA transport_Homo sapiens_hsa030131.15899879
62Mismatch repair_Homo sapiens_hsa034301.15122543
63Glioma_Homo sapiens_hsa052141.14804464
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11846189
65Estrogen signaling pathway_Homo sapiens_hsa049151.11778754
66Nucleotide excision repair_Homo sapiens_hsa034201.10799766
67Base excision repair_Homo sapiens_hsa034101.09596496
68ErbB signaling pathway_Homo sapiens_hsa040121.09540000
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08123657
70Melanogenesis_Homo sapiens_hsa049161.07967930
71Steroid biosynthesis_Homo sapiens_hsa001001.07206060
72Type II diabetes mellitus_Homo sapiens_hsa049301.05919343
73Propanoate metabolism_Homo sapiens_hsa006401.03280682
74cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02855144
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01148209
76Phototransduction_Homo sapiens_hsa047440.99724204
77Tryptophan metabolism_Homo sapiens_hsa003800.98824211
78Vibrio cholerae infection_Homo sapiens_hsa051100.94820509
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.93542096
80Purine metabolism_Homo sapiens_hsa002300.93126590
81Pyrimidine metabolism_Homo sapiens_hsa002400.92910467
82Oocyte meiosis_Homo sapiens_hsa041140.89738615
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88000549
84Cardiac muscle contraction_Homo sapiens_hsa042600.87749952
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.84232447
86Ribosome_Homo sapiens_hsa030100.83189869
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82535536
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.81450736
89Proteasome_Homo sapiens_hsa030500.80528788
90Hedgehog signaling pathway_Homo sapiens_hsa043400.80509520
91Folate biosynthesis_Homo sapiens_hsa007900.80156151
92Dorso-ventral axis formation_Homo sapiens_hsa043200.79715116
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78929451
94Sulfur relay system_Homo sapiens_hsa041220.78919677
95Spliceosome_Homo sapiens_hsa030400.77183541
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76948659
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74513515
98Choline metabolism in cancer_Homo sapiens_hsa052310.73541165
99Pancreatic secretion_Homo sapiens_hsa049720.73114282
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72217868
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71712852
102MAPK signaling pathway_Homo sapiens_hsa040100.71251530
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71217435
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71040751
105Thyroid hormone synthesis_Homo sapiens_hsa049180.68285237
106Ras signaling pathway_Homo sapiens_hsa040140.67082918
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67023310
108ABC transporters_Homo sapiens_hsa020100.66532265
109Alcoholism_Homo sapiens_hsa050340.65589955
110Dilated cardiomyopathy_Homo sapiens_hsa054140.64852983
111Rap1 signaling pathway_Homo sapiens_hsa040150.62661527
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61951049
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60297438
114Metabolic pathways_Homo sapiens_hsa011000.59291516
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.58466268
116VEGF signaling pathway_Homo sapiens_hsa043700.57776467
117Fatty acid elongation_Homo sapiens_hsa000620.55304184
118Lysine degradation_Homo sapiens_hsa003100.54578452
119Peroxisome_Homo sapiens_hsa041460.54151184
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53367878
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52864742
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.52754659
123Glucagon signaling pathway_Homo sapiens_hsa049220.52035550
124beta-Alanine metabolism_Homo sapiens_hsa004100.50788641
125Wnt signaling pathway_Homo sapiens_hsa043100.49887988
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49135421
127Basal cell carcinoma_Homo sapiens_hsa052170.48291534
128Type I diabetes mellitus_Homo sapiens_hsa049400.47827433
129Nitrogen metabolism_Homo sapiens_hsa009100.47786209
130Ovarian steroidogenesis_Homo sapiens_hsa049130.47740644
131Alzheimers disease_Homo sapiens_hsa050100.45484930
132mRNA surveillance pathway_Homo sapiens_hsa030150.44670350
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44586354
134Prion diseases_Homo sapiens_hsa050200.44249611
135Endometrial cancer_Homo sapiens_hsa052130.43675784
136Hippo signaling pathway_Homo sapiens_hsa043900.43145307
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42490088
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41004342
139Endocytosis_Homo sapiens_hsa041440.40868801
140Circadian rhythm_Homo sapiens_hsa047100.40865489
141Renal cell carcinoma_Homo sapiens_hsa052110.40691996
142Non-small cell lung cancer_Homo sapiens_hsa052230.40486721
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39286455
144Cell cycle_Homo sapiens_hsa041100.37489205
145mTOR signaling pathway_Homo sapiens_hsa041500.37459697
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.37281151
147African trypanosomiasis_Homo sapiens_hsa051430.36194922
148Retinol metabolism_Homo sapiens_hsa008300.36033926
149Arginine and proline metabolism_Homo sapiens_hsa003300.35870646
150Bile secretion_Homo sapiens_hsa049760.35340451
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35090824
152Inositol phosphate metabolism_Homo sapiens_hsa005620.34870863
153Chemical carcinogenesis_Homo sapiens_hsa052040.34806544
154Chemokine signaling pathway_Homo sapiens_hsa040620.34598406
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33785838
156Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32883056
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32509049
158p53 signaling pathway_Homo sapiens_hsa041150.32490443
159Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32462169
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32396855
161Colorectal cancer_Homo sapiens_hsa052100.32072881
162Insulin signaling pathway_Homo sapiens_hsa049100.30621631
163Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27587417
164Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23963431
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23536012
166Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23329788

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