HRH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.45792293
2synaptic vesicle maturation (GO:0016188)6.42631177
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.12763203
4locomotory exploration behavior (GO:0035641)6.03509433
5vocalization behavior (GO:0071625)5.59022048
6synaptic vesicle exocytosis (GO:0016079)5.53211364
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.50966426
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40529782
9regulation of synapse structural plasticity (GO:0051823)5.31148154
10cerebellar granule cell differentiation (GO:0021707)5.16805598
11regulation of glutamate receptor signaling pathway (GO:1900449)5.16155568
12glutamate secretion (GO:0014047)5.09013292
13regulation of synaptic vesicle exocytosis (GO:2000300)5.08654942
14synaptic vesicle docking involved in exocytosis (GO:0016081)5.02531401
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.94153109
16regulation of neuronal synaptic plasticity (GO:0048168)4.83525093
17postsynaptic membrane organization (GO:0001941)4.75917401
18protein localization to synapse (GO:0035418)4.64097599
19neuronal action potential propagation (GO:0019227)4.60170061
20* neurotransmitter secretion (GO:0007269)4.57932564
21prepulse inhibition (GO:0060134)4.57730513
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.55502069
23regulation of synaptic vesicle transport (GO:1902803)4.54436382
24L-amino acid import (GO:0043092)4.46660120
25exploration behavior (GO:0035640)4.42752560
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.42386400
27neurotransmitter-gated ion channel clustering (GO:0072578)4.39948760
28dendritic spine morphogenesis (GO:0060997)4.31978491
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.27851970
30layer formation in cerebral cortex (GO:0021819)4.20088424
31central nervous system myelination (GO:0022010)4.18998803
32axon ensheathment in central nervous system (GO:0032291)4.18998803
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17340579
34long-term memory (GO:0007616)4.16688173
35synaptic transmission, glutamatergic (GO:0035249)4.15915271
36neuron-neuron synaptic transmission (GO:0007270)4.15158261
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.13320465
38regulation of synapse maturation (GO:0090128)4.12835122
39positive regulation of membrane potential (GO:0045838)4.11677126
40regulation of excitatory postsynaptic membrane potential (GO:0060079)4.06374317
41synaptic transmission, dopaminergic (GO:0001963)4.05816381
42auditory behavior (GO:0031223)4.03362700
43gamma-aminobutyric acid transport (GO:0015812)4.03321742
44amino acid import (GO:0043090)4.02399331
45regulation of ARF protein signal transduction (GO:0032012)4.01467892
46positive regulation of synaptic transmission, GABAergic (GO:0032230)4.00582498
47neuron cell-cell adhesion (GO:0007158)3.99687287
48regulation of dendritic spine morphogenesis (GO:0061001)3.98262435
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.96835006
50glutamate receptor signaling pathway (GO:0007215)3.93872608
51striatum development (GO:0021756)3.90451398
52positive regulation of neurotransmitter transport (GO:0051590)3.89607862
53behavioral response to cocaine (GO:0048148)3.84746179
54neuromuscular process controlling balance (GO:0050885)3.84340054
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81691708
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.81671855
57regulation of postsynaptic membrane potential (GO:0060078)3.81529980
58activation of protein kinase A activity (GO:0034199)3.79647131
59potassium ion homeostasis (GO:0055075)3.79113115
60regulation of synaptic plasticity (GO:0048167)3.78003997
61response to auditory stimulus (GO:0010996)3.76044624
62cell migration in hindbrain (GO:0021535)3.71961287
63cellular potassium ion homeostasis (GO:0030007)3.68734620
64transmission of nerve impulse (GO:0019226)3.68092895
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.67291543
66cell communication by electrical coupling (GO:0010644)3.65370091
67* neurotransmitter transport (GO:0006836)3.65197894
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.63263683
69positive regulation of neurotransmitter secretion (GO:0001956)3.61411330
70adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.61290926
71potassium ion import (GO:0010107)3.60621887
72neuromuscular process controlling posture (GO:0050884)3.57974944
73proline transport (GO:0015824)3.57871560
74cell differentiation in hindbrain (GO:0021533)3.57596168
75long-term synaptic potentiation (GO:0060291)3.56242450
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.55760814
77neuromuscular synaptic transmission (GO:0007274)3.54011744
78negative regulation of dendrite morphogenesis (GO:0050774)3.52892139
79dopamine receptor signaling pathway (GO:0007212)3.49609401
80neuronal ion channel clustering (GO:0045161)3.49272416
81regulation of female receptivity (GO:0045924)3.47691781
82regulation of neurotransmitter secretion (GO:0046928)3.47404998
83sodium ion export (GO:0071436)3.46723794
84* regulation of neurotransmitter levels (GO:0001505)3.46352625
85membrane hyperpolarization (GO:0060081)3.45902206
86glycine transport (GO:0015816)3.44941985
87response to amphetamine (GO:0001975)3.44787355
88regulation of neurotransmitter transport (GO:0051588)3.39968245
89response to histamine (GO:0034776)3.36394787
90regulation of vesicle fusion (GO:0031338)3.35667532
91negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35358560
92positive regulation of synapse maturation (GO:0090129)3.31969823
93regulation of voltage-gated calcium channel activity (GO:1901385)3.28102429
94regulation of dendritic spine development (GO:0060998)3.27916292
95membrane depolarization (GO:0051899)3.27370571
96regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26719499
97regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26719499
98synaptic vesicle endocytosis (GO:0048488)3.26685975
99behavioral defense response (GO:0002209)3.26097748
100behavioral fear response (GO:0001662)3.26097748
101cellular sodium ion homeostasis (GO:0006883)3.25761009
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23958600
103positive regulation of synaptic transmission (GO:0050806)3.23119911
104mating behavior (GO:0007617)3.22102247
105visual learning (GO:0008542)3.21149483
106cytoskeletal anchoring at plasma membrane (GO:0007016)3.20934317
107chemosensory behavior (GO:0007635)3.20122420
108adenosine receptor signaling pathway (GO:0001973)3.19988460
109regulation of synaptic transmission (GO:0050804)3.19899871
110membrane depolarization during action potential (GO:0086010)3.18910678
111gamma-aminobutyric acid signaling pathway (GO:0007214)3.18903608
112cerebellar Purkinje cell differentiation (GO:0021702)3.16982595
113presynaptic membrane organization (GO:0097090)3.16729790
114female mating behavior (GO:0060180)3.16574571
115* learning (GO:0007612)3.15466494
116acidic amino acid transport (GO:0015800)3.14608543
117neuron recognition (GO:0008038)3.13795676
118establishment of synaptic vesicle localization (GO:0097480)3.13193345
119synaptic vesicle transport (GO:0048489)3.13193345
120positive regulation of dendritic spine development (GO:0060999)3.12820148
121dendritic spine organization (GO:0097061)3.12688073
122synaptic transmission (GO:0007268)3.11765762
123mechanosensory behavior (GO:0007638)3.10783830
124neuromuscular process (GO:0050905)3.09254580
125negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08210752
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08130909
127regulation of synaptic transmission, GABAergic (GO:0032228)3.06982596
128adult walking behavior (GO:0007628)3.05151826
129positive regulation of dendrite development (GO:1900006)3.04624701
130intraspecies interaction between organisms (GO:0051703)3.03499223
131social behavior (GO:0035176)3.03499223
132vesicle docking involved in exocytosis (GO:0006904)2.99733693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05439907
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.35831225
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26233140
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16550207
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15573070
6GBX2_23144817_ChIP-Seq_PC3_Human3.14848861
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.86194346
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84307030
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84307030
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79985870
11DROSHA_22980978_ChIP-Seq_HELA_Human2.78546721
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68890675
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66440295
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65463789
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.58280798
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57352035
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.54902879
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50903150
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46574337
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43520169
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.39849456
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37749180
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.36751607
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.28885588
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26314040
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.16985527
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16594810
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06484592
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.91536849
30AR_21572438_ChIP-Seq_LNCaP_Human1.90294389
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89392664
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84440392
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60378676
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55135595
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54786382
36LXR_22292898_ChIP-Seq_THP-1_Human1.52627211
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51867836
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51474976
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51333251
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45180288
41SMAD4_21799915_ChIP-Seq_A2780_Human1.43437169
42* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42251607
43TAF15_26573619_Chip-Seq_HEK293_Human1.39807881
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.37161718
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34705865
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34563406
47KDM2B_26808549_Chip-Seq_K562_Human1.28776186
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27378616
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27284055
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26886291
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25750405
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24827187
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24378556
54* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24224113
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.24053458
56OCT4_19829295_ChIP-Seq_ESCs_Human1.22321995
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21712948
58* SMC4_20622854_ChIP-Seq_HELA_Human1.20853678
59AR_19668381_ChIP-Seq_PC3_Human1.20642223
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19544824
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17642845
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.17480027
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17293615
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15534956
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15399875
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15399840
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14728098
68* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14371985
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13505622
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.12356763
71* P68_20966046_ChIP-Seq_HELA_Human1.11501209
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09530792
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.09438436
74STAT3_23295773_ChIP-Seq_U87_Human1.09065496
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.07796573
76* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07528957
77P300_19829295_ChIP-Seq_ESCs_Human1.07516560
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06674802
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06536307
80AR_25329375_ChIP-Seq_VCAP_Human1.06026588
81ZNF274_21170338_ChIP-Seq_K562_Hela1.05560747
82CREB1_26743006_Chip-Seq_LNCaP_Human1.05144153
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03612227
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03067060
85DPY_21335234_ChIP-Seq_ESCs_Mouse1.01539870
86CTCF_27219007_Chip-Seq_Bcells_Human1.00364735
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.99702331
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99589410
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99565895
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.99490872
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99052229
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96828825
93KDM2B_26808549_Chip-Seq_DND41_Human0.96266314
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.96055843
95TCF4_23295773_ChIP-Seq_U87_Human0.95920639
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.95511272
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.95475151
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95248822
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94756623
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94513262
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93576730
102TET1_21490601_ChIP-Seq_MESCs_Mouse0.92522625
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.92158627
104BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92147271
105* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91772938
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88812808
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.88459438
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.88330403
109AHR_22903824_ChIP-Seq_MCF-7_Human0.87600024
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86243918
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85837165
112RNF2_27304074_Chip-Seq_NSC_Mouse0.85528863
113SMAD4_21741376_ChIP-Seq_ESCs_Human0.84709275
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.84383817
115RUNX2_22187159_ChIP-Seq_PCA_Human0.84202284
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.84172578
117KLF4_19829295_ChIP-Seq_ESCs_Human0.83460382
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83404943
119RXR_22108803_ChIP-Seq_LS180_Human0.83298260
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83231570
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82642157
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.82189664
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82165933
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81900054
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80911128
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80493303
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79651992
128TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78765296
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78329349
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78329349
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78275790
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77514179
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76452827
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.76199758
135SA1_27219007_Chip-Seq_Bcells_Human0.75296841
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.73851961
137POU5F1_16518401_ChIP-PET_MESCs_Mouse0.73795593
138SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72741692
139* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.72541890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.79944443
2MP0002822_catalepsy5.54797276
3MP0003880_abnormal_central_pattern4.79220626
4* MP0003635_abnormal_synaptic_transmissio4.30732300
5MP0009745_abnormal_behavioral_response3.74451623
6MP0004270_analgesia3.51072362
7* MP0002063_abnormal_learning/memory/cond3.48020264
8MP0002064_seizures3.32958835
9MP0009046_muscle_twitch3.16919039
10MP0005423_abnormal_somatic_nervous3.06178901
11* MP0002572_abnormal_emotion/affect_behav2.84909639
12MP0001968_abnormal_touch/_nociception2.78623779
13MP0001486_abnormal_startle_reflex2.73250044
14MP0002272_abnormal_nervous_system2.68250168
15MP0001501_abnormal_sleep_pattern2.49640831
16MP0002734_abnormal_mechanical_nocicepti2.41800055
17MP0002909_abnormal_adrenal_gland2.12714551
18MP0005646_abnormal_pituitary_gland2.04276503
19MP0001529_abnormal_vocalization2.00273775
20MP0001440_abnormal_grooming_behavior1.94434215
21MP0002736_abnormal_nociception_after1.94114337
22MP0008569_lethality_at_weaning1.90585194
23MP0001970_abnormal_pain_threshold1.90026350
24MP0002733_abnormal_thermal_nociception1.89432674
25MP0004924_abnormal_behavior1.82853827
26MP0005386_behavior/neurological_phenoty1.82853827
27MP0002557_abnormal_social/conspecific_i1.76812584
28MP0002067_abnormal_sensory_capabilities1.76591029
29MP0004811_abnormal_neuron_physiology1.75105669
30MP0009780_abnormal_chondrocyte_physiolo1.67449345
31MP0001984_abnormal_olfaction1.65744574
32MP0003879_abnormal_hair_cell1.62773294
33MP0003329_amyloid_beta_deposits1.61690149
34MP0002735_abnormal_chemical_nociception1.54666210
35MP0002184_abnormal_innervation1.52252576
36MP0004858_abnormal_nervous_system1.49652301
37MP0006276_abnormal_autonomic_nervous1.39492408
38MP0000955_abnormal_spinal_cord1.39106159
39* MP0002066_abnormal_motor_capabilities/c1.38106914
40MP0004885_abnormal_endolymph1.34757127
41MP0001905_abnormal_dopamine_level1.34564339
42MP0005645_abnormal_hypothalamus_physiol1.33672187
43MP0003787_abnormal_imprinting1.32575851
44MP0000778_abnormal_nervous_system1.32133809
45MP0001348_abnormal_lacrimal_gland1.30858024
46MP0002882_abnormal_neuron_morphology1.30733666
47MP0008872_abnormal_physiological_respon1.29915735
48MP0003122_maternal_imprinting1.25760222
49* MP0003633_abnormal_nervous_system1.24763462
50MP0001502_abnormal_circadian_rhythm1.24535318
51MP0003075_altered_response_to1.23747275
52MP0002653_abnormal_ependyma_morphology1.21340293
53MP0004142_abnormal_muscle_tone1.19058130
54MP0008874_decreased_physiological_sensi1.16113973
55MP0008961_abnormal_basal_metabolism1.13255494
56MP0001177_atelectasis1.12084092
57MP0001188_hyperpigmentation1.09817766
58MP0004147_increased_porphyrin_level1.09548157
59MP0003283_abnormal_digestive_organ1.07054255
60MP0000751_myopathy1.05892799
61MP0000013_abnormal_adipose_tissue1.04293014
62* MP0003631_nervous_system_phenotype1.04025589
63MP0005409_darkened_coat_color1.02254443
64MP0002152_abnormal_brain_morphology1.00798026
65* MP0002069_abnormal_eating/drinking_beha0.97608534
66MP0003690_abnormal_glial_cell0.93717718
67MP0002090_abnormal_vision0.93198652
68MP0004085_abnormal_heartbeat0.91280262
69MP0002229_neurodegeneration0.90079150
70MP0005551_abnormal_eye_electrophysiolog0.89012801
71MP0001346_abnormal_lacrimal_gland0.86173628
72* MP0005535_abnormal_body_temperature0.85039152
73MP0005499_abnormal_olfactory_system0.83763746
74MP0005394_taste/olfaction_phenotype0.83763746
75MP0003121_genomic_imprinting0.82909826
76MP0000920_abnormal_myelination0.79429491
77MP0010234_abnormal_vibrissa_follicle0.78645699
78MP0003861_abnormal_nervous_system0.78559363
79MP0000569_abnormal_digit_pigmentation0.76951159
80MP0002249_abnormal_larynx_morphology0.76604827
81MP0008877_abnormal_DNA_methylation0.72951049
82MP0010386_abnormal_urinary_bladder0.72725256
83MP0003634_abnormal_glial_cell0.72485603
84MP0003878_abnormal_ear_physiology0.71976830
85MP0005377_hearing/vestibular/ear_phenot0.71976830
86MP0000631_abnormal_neuroendocrine_gland0.71889669
87MP0004130_abnormal_muscle_cell0.71733659
88MP0003632_abnormal_nervous_system0.70249664
89MP0000604_amyloidosis0.69527763
90MP0003137_abnormal_impulse_conducting0.68141181
91MP0004742_abnormal_vestibular_system0.65751095
92MP0000026_abnormal_inner_ear0.64511692
93MP0004145_abnormal_muscle_electrophysio0.64107499
94MP0001664_abnormal_digestion0.62111779
95MP0001963_abnormal_hearing_physiology0.60799033
96MP0002638_abnormal_pupillary_reflex0.60074478
97MP0004133_heterotaxia0.60053345
98MP0003123_paternal_imprinting0.59815636
99MP0002752_abnormal_somatic_nervous0.59229888
100MP0003938_abnormal_ear_development0.58746154
101MP0003183_abnormal_peptide_metabolism0.54132620
102MP0004233_abnormal_muscle_weight0.53836564
103MP0001943_abnormal_respiration0.53525311
104MP0005623_abnormal_meninges_morphology0.53222914
105MP0004510_myositis0.51554065
106MP0001299_abnormal_eye_distance/0.51421558
107MP0004215_abnormal_myocardial_fiber0.50544270
108MP0001485_abnormal_pinna_reflex0.49939867
109* MP0003956_abnormal_body_size0.49482086
110MP0010769_abnormal_survival0.49249926
111MP0005166_decreased_susceptibility_to0.48620305
112MP0004043_abnormal_pH_regulation0.48569826
113MP0010770_preweaning_lethality0.46710184
114MP0002082_postnatal_lethality0.46710184
115MP0010768_mortality/aging0.45970765
116MP0003172_abnormal_lysosome_physiology0.44183240

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.52489746
2Focal motor seizures (HP:0011153)8.17988298
3Focal seizures (HP:0007359)6.03895824
4Visual hallucinations (HP:0002367)5.17029479
5Epileptic encephalopathy (HP:0200134)4.59422465
6Febrile seizures (HP:0002373)4.35322102
7Atonic seizures (HP:0010819)4.31219191
8Absence seizures (HP:0002121)4.11930762
9Action tremor (HP:0002345)4.11485948
10Generalized tonic-clonic seizures (HP:0002069)3.94864968
11Progressive cerebellar ataxia (HP:0002073)3.89870904
12Ankle clonus (HP:0011448)3.89811119
13Poor eye contact (HP:0000817)3.82064129
14Impaired vibration sensation in the lower limbs (HP:0002166)3.80693693
15Dialeptic seizures (HP:0011146)3.71041253
16Depression (HP:0000716)3.70596234
17Anxiety (HP:0000739)3.57685064
18Broad-based gait (HP:0002136)3.57341202
19Dysdiadochokinesis (HP:0002075)3.49056832
20Abnormal social behavior (HP:0012433)3.47103196
21Impaired social interactions (HP:0000735)3.47103196
22Torticollis (HP:0000473)3.44744345
23Postural instability (HP:0002172)3.42705615
24Cerebral hypomyelination (HP:0006808)3.40243814
25Supranuclear gaze palsy (HP:0000605)3.39945417
26Urinary bladder sphincter dysfunction (HP:0002839)3.39648471
27Gaze-evoked nystagmus (HP:0000640)3.37147443
28Annular pancreas (HP:0001734)3.37065998
29Papilledema (HP:0001085)3.29964683
30Dysmetria (HP:0001310)3.25926928
31Abnormal eating behavior (HP:0100738)3.15212511
32Focal dystonia (HP:0004373)3.12560708
33Tetraplegia (HP:0002445)3.06603059
34Resting tremor (HP:0002322)2.98923968
35Truncal ataxia (HP:0002078)2.97322849
36Urinary urgency (HP:0000012)2.90959283
37Craniofacial dystonia (HP:0012179)2.88658866
38Sleep apnea (HP:0010535)2.88202004
39Mutism (HP:0002300)2.86482031
40Ventricular fibrillation (HP:0001663)2.86080478
41Impaired smooth pursuit (HP:0007772)2.83969969
42Scanning speech (HP:0002168)2.81437706
43Stereotypic behavior (HP:0000733)2.76186244
44Bradykinesia (HP:0002067)2.75284544
45Amblyopia (HP:0000646)2.73208372
46Abnormality of the lower motor neuron (HP:0002366)2.71146727
47Hyperventilation (HP:0002883)2.66872650
48Hemiplegia (HP:0002301)2.65977090
49Spastic gait (HP:0002064)2.65830494
50Progressive inability to walk (HP:0002505)2.63719297
51Dysmetric saccades (HP:0000641)2.61582295
52Genetic anticipation (HP:0003743)2.61558388
53Intention tremor (HP:0002080)2.59055542
54Akinesia (HP:0002304)2.57482425
55Pointed chin (HP:0000307)2.56925194
56Impaired vibratory sensation (HP:0002495)2.54337655
57Status epilepticus (HP:0002133)2.53228019
58Ankyloglossia (HP:0010296)2.48238947
59Hemiparesis (HP:0001269)2.45551377
60Abnormality of ocular smooth pursuit (HP:0000617)2.41445699
61Abnormal EKG (HP:0003115)2.34228209
62Abnormality of the corticospinal tract (HP:0002492)2.33905370
63Bronchomalacia (HP:0002780)2.33264875
64Megalencephaly (HP:0001355)2.31801418
65Peripheral hypomyelination (HP:0007182)2.29378464
66Limb dystonia (HP:0002451)2.29211345
67Choreoathetosis (HP:0001266)2.26205949
68Spastic tetraparesis (HP:0001285)2.25347845
69Apathy (HP:0000741)2.24088092
70Lower limb muscle weakness (HP:0007340)2.22832148
71Prolonged QT interval (HP:0001657)2.21277260
72Neurofibrillary tangles (HP:0002185)2.21075980
73Drooling (HP:0002307)2.20823819
74Excessive salivation (HP:0003781)2.20823819
75Lower limb amyotrophy (HP:0007210)2.20598209
76Clonus (HP:0002169)2.19720030
77Epileptiform EEG discharges (HP:0011182)2.19361543
78EEG with generalized epileptiform discharges (HP:0011198)2.14076644
79Cerebral inclusion bodies (HP:0100314)2.13148175
80Diminished motivation (HP:0000745)2.12130759
81Incomplete penetrance (HP:0003829)2.11781504
82Bundle branch block (HP:0011710)2.10124738
83CNS hypomyelination (HP:0003429)2.09406973
84Abnormality of binocular vision (HP:0011514)2.08257556
85Diplopia (HP:0000651)2.08257556
86Insomnia (HP:0100785)2.06804126
87Neuronal loss in central nervous system (HP:0002529)2.04929771
88Polyphagia (HP:0002591)2.04772987
89Generalized myoclonic seizures (HP:0002123)2.04650355
90Hypsarrhythmia (HP:0002521)2.04059965
91Abnormality of saccadic eye movements (HP:0000570)2.03358583
92Turricephaly (HP:0000262)2.02260341
93Fetal akinesia sequence (HP:0001989)1.98315696
94Rigidity (HP:0002063)1.95926077
95Truncus arteriosus (HP:0001660)1.95873623
96Absent speech (HP:0001344)1.93349376
97Inability to walk (HP:0002540)1.92614067
98Gait ataxia (HP:0002066)1.92317450
99Pheochromocytoma (HP:0002666)1.89850129
100Delusions (HP:0000746)1.88613608
101Insidious onset (HP:0003587)1.87533343
102Termporal pattern (HP:0011008)1.87533343
103Lower limb asymmetry (HP:0100559)1.82384883
104Spinal canal stenosis (HP:0003416)1.81907424
105Psychosis (HP:0000709)1.81820466
106Hypoventilation (HP:0002791)1.81021189
107Failure to thrive in infancy (HP:0001531)1.80928321
108Morphological abnormality of the pyramidal tract (HP:0002062)1.80616963
109Hepatoblastoma (HP:0002884)1.80569987
110Abnormality of the periventricular white matter (HP:0002518)1.80567667
111Abnormality of oral frenula (HP:0000190)1.79304912
112Obstructive sleep apnea (HP:0002870)1.78138642
113Aplasia involving bones of the extremities (HP:0009825)1.74531768
114Aplasia involving bones of the upper limbs (HP:0009823)1.74531768
115Aplasia of the phalanges of the hand (HP:0009802)1.74531768
116Rapidly progressive (HP:0003678)1.73991674
117Generalized hypotonia (HP:0001290)1.73581328
118Blue irides (HP:0000635)1.72332605
119Split foot (HP:0001839)1.64240456
120Unsteady gait (HP:0002317)1.62555796
121Hand muscle atrophy (HP:0009130)1.61518320
122Anomalous pulmonary venous return (HP:0010772)1.59541612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.99442133
2NTRK34.35565282
3MAP3K93.96747538
4DAPK22.99251343
5MAP3K42.61170659
6PRKD32.59121845
7KSR22.51801044
8MINK12.47985361
9PAK62.23348301
10CAMKK12.17557247
11RIPK42.15720645
12NTRK22.11959830
13NTRK12.07220955
14MAP2K71.99848753
15ARAF1.96393038
16MARK11.90280489
17KSR11.79045553
18DAPK11.72013096
19CAMK1D1.70925785
20MAP3K131.68742819
21CDK51.61733920
22MAP3K121.58256693
23MAP2K41.57940174
24TAOK11.55918554
25FES1.53048727
26TNIK1.46529383
27STK381.44084340
28SIK21.40083658
29INSRR1.39809519
30CAMKK21.31422518
31MAP3K21.31063570
32TYRO31.28981275
33GRK51.22867365
34CDK191.19104831
35PRPF4B1.17339168
36UHMK11.12374073
37PRKCG1.09521531
38PLK21.08109465
39RAF11.06912943
40PINK11.03164679
41CAMK11.01546181
42PRKCH0.98490919
43SGK4940.96433866
44SGK2230.96433866
45CDK180.96394840
46STK110.95314318
47TNK20.95280948
48CDK150.93239088
49MAP3K110.90791406
50ALK0.89733354
51PNCK0.88650998
52CDK140.87994941
53MAPK130.85147441
54CAMK2A0.84164226
55CASK0.82012750
56CDK11A0.81718625
57SGK20.79056601
58SGK30.76726017
59BMPR20.76714351
60MAP3K10.74350518
61MARK20.72294723
62SGK10.71844283
63PDK10.70912859
64RET0.70803779
65NEK10.68710972
66PDPK10.68289097
67PTK2B0.65826741
68CAMK2B0.65239413
69PKN10.64604422
70FGFR20.61182451
71SIK30.61016079
72DAPK30.59989246
73RIPK10.59940145
74IRAK20.59782442
75BRSK10.59288819
76NEK60.58522243
77ICK0.58087008
78LMTK20.57954516
79MAPK120.57694359
80OXSR10.56039696
81PAK30.55702412
82PHKG20.54010146
83PHKG10.54010146
84LATS20.53984425
85RPS6KA30.52063304
86MAP3K70.49211384
87DYRK1A0.48530809
88CAMK40.47238704
89PRKCZ0.46753641
90LIMK10.46337246
91DYRK20.46154195
92MAPK100.45728867
93SCYL20.45707228
94BRAF0.44761278
95MAP2K10.44543568
96FYN0.44178721
97PRKG20.41309975
98ERBB20.41190615
99CAMK2G0.40816284
100CDC42BPA0.40580503
101CAMK1G0.39282872
102CSNK1G20.38341696
103MOS0.36310963
104PRKCE0.34978172
105CAMK2D0.34717267
106DMPK0.33926335
107MAPK80.33736880
108WNK10.33612808
109PRKD20.32626889
110PRKCB0.31965152
111GSK3B0.29653118
112TRIB30.28964714
113PRKAA10.28708880
114AKT30.28193557
115DYRK1B0.28186156
116PRKCA0.27518843
117CSNK1E0.27180935
118RPS6KA20.26982134
119ROCK20.25439878
120CSNK1A10.24919595

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.47111253
2Synaptic vesicle cycle_Homo sapiens_hsa047213.38639126
3Olfactory transduction_Homo sapiens_hsa047403.28673874
4GABAergic synapse_Homo sapiens_hsa047272.88131914
5Morphine addiction_Homo sapiens_hsa050322.76517006
6Circadian entrainment_Homo sapiens_hsa047132.74436898
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59579362
8Amphetamine addiction_Homo sapiens_hsa050312.59456836
9Long-term potentiation_Homo sapiens_hsa047202.57871198
10Glutamatergic synapse_Homo sapiens_hsa047242.55229412
11Dopaminergic synapse_Homo sapiens_hsa047282.27649886
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16888961
13Salivary secretion_Homo sapiens_hsa049702.16633302
14Cocaine addiction_Homo sapiens_hsa050302.13437578
15Cholinergic synapse_Homo sapiens_hsa047252.04822989
16Insulin secretion_Homo sapiens_hsa049112.01766016
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90108183
18Gastric acid secretion_Homo sapiens_hsa049711.89761404
19Renin secretion_Homo sapiens_hsa049241.74930121
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70818643
21Oxytocin signaling pathway_Homo sapiens_hsa049211.70605666
22Nitrogen metabolism_Homo sapiens_hsa009101.67471761
23Taste transduction_Homo sapiens_hsa047421.65778097
24Vitamin B6 metabolism_Homo sapiens_hsa007501.62790482
25Calcium signaling pathway_Homo sapiens_hsa040201.62431409
26Serotonergic synapse_Homo sapiens_hsa047261.61718966
27Long-term depression_Homo sapiens_hsa047301.54809353
28GnRH signaling pathway_Homo sapiens_hsa049121.47287194
29Gap junction_Homo sapiens_hsa045401.44751756
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41540425
31Collecting duct acid secretion_Homo sapiens_hsa049661.35619401
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32554773
33cAMP signaling pathway_Homo sapiens_hsa040241.30748270
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27257803
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14519740
36Glioma_Homo sapiens_hsa052141.13343004
37Type II diabetes mellitus_Homo sapiens_hsa049301.11624786
38Estrogen signaling pathway_Homo sapiens_hsa049151.10537943
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08684783
40Fatty acid biosynthesis_Homo sapiens_hsa000611.04467603
41Melanogenesis_Homo sapiens_hsa049161.00760149
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99551783
43* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95840753
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.95165706
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95109477
46ErbB signaling pathway_Homo sapiens_hsa040120.94469200
47Cardiac muscle contraction_Homo sapiens_hsa042600.93916816
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.87642200
49Oocyte meiosis_Homo sapiens_hsa041140.87478335
50Phototransduction_Homo sapiens_hsa047440.85960964
51Axon guidance_Homo sapiens_hsa043600.84850203
52Vibrio cholerae infection_Homo sapiens_hsa051100.81789548
53Dorso-ventral axis formation_Homo sapiens_hsa043200.79644181
54Pancreatic secretion_Homo sapiens_hsa049720.79604962
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78736945
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77462688
57Dilated cardiomyopathy_Homo sapiens_hsa054140.75773516
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73990199
59Type I diabetes mellitus_Homo sapiens_hsa049400.73898344
60Arginine and proline metabolism_Homo sapiens_hsa003300.70646686
61Alcoholism_Homo sapiens_hsa050340.70137940
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68858374
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66151140
64MAPK signaling pathway_Homo sapiens_hsa040100.66092622
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61577681
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60973252
67Choline metabolism in cancer_Homo sapiens_hsa052310.60703211
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.60553100
69Non-small cell lung cancer_Homo sapiens_hsa052230.60490465
70Rap1 signaling pathway_Homo sapiens_hsa040150.59644810
71VEGF signaling pathway_Homo sapiens_hsa043700.57457871
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57080584
73Bile secretion_Homo sapiens_hsa049760.56353506
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55701129
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55444216
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55322694
77Glucagon signaling pathway_Homo sapiens_hsa049220.52321871
78Ras signaling pathway_Homo sapiens_hsa040140.50981729
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.48539191
80Endocytosis_Homo sapiens_hsa041440.48509179
81Inositol phosphate metabolism_Homo sapiens_hsa005620.47114837
82mTOR signaling pathway_Homo sapiens_hsa041500.46826099
83Prion diseases_Homo sapiens_hsa050200.46354506
84Circadian rhythm_Homo sapiens_hsa047100.45977140
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45248099
86Chemokine signaling pathway_Homo sapiens_hsa040620.43023919
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40829979
88Notch signaling pathway_Homo sapiens_hsa043300.40617843
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40406842
90Hippo signaling pathway_Homo sapiens_hsa043900.37886677
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37707500
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37602095
93Ovarian steroidogenesis_Homo sapiens_hsa049130.36458571
94Endometrial cancer_Homo sapiens_hsa052130.35884948
95AMPK signaling pathway_Homo sapiens_hsa041520.35772513
96Insulin signaling pathway_Homo sapiens_hsa049100.35730031
97African trypanosomiasis_Homo sapiens_hsa051430.35339832
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33166304
99Arginine biosynthesis_Homo sapiens_hsa002200.31544656
100Tight junction_Homo sapiens_hsa045300.31534381
101Renal cell carcinoma_Homo sapiens_hsa052110.30509220
102Wnt signaling pathway_Homo sapiens_hsa043100.29462101
103Alzheimers disease_Homo sapiens_hsa050100.26770493
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26187573
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25675531
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25240399
107Platelet activation_Homo sapiens_hsa046110.24756103
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.23607063
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22810844
110Histidine metabolism_Homo sapiens_hsa003400.22407951
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21417766
112beta-Alanine metabolism_Homo sapiens_hsa004100.18628488
113HIF-1 signaling pathway_Homo sapiens_hsa040660.17672078

Most similar genes based on co-expression Upload to Enrichr

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