HRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.88728061
2epoxygenase P450 pathway (GO:0019373)7.99268889
3omega-hydroxylase P450 pathway (GO:0097267)7.66816419
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65247727
5L-phenylalanine catabolic process (GO:0006559)7.65247727
6L-phenylalanine metabolic process (GO:0006558)7.31706724
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31706724
8aromatic amino acid family catabolic process (GO:0009074)6.87976429
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.46460171
10oxidative demethylation (GO:0070989)6.32851770
11drug metabolic process (GO:0017144)6.24520561
12tryptophan catabolic process (GO:0006569)6.19842122
13indole-containing compound catabolic process (GO:0042436)6.19842122
14indolalkylamine catabolic process (GO:0046218)6.19842122
15kynurenine metabolic process (GO:0070189)6.07916553
16phenylpropanoid metabolic process (GO:0009698)5.98390708
17bile acid biosynthetic process (GO:0006699)5.96973278
18glyoxylate metabolic process (GO:0046487)5.82985912
19tryptophan metabolic process (GO:0006568)5.82880783
20urea cycle (GO:0000050)5.74890276
21urea metabolic process (GO:0019627)5.74890276
22high-density lipoprotein particle remodeling (GO:0034375)5.71528630
23alpha-linolenic acid metabolic process (GO:0036109)5.58391596
24protein carboxylation (GO:0018214)5.47479946
25peptidyl-glutamic acid carboxylation (GO:0017187)5.47479946
26complement activation, alternative pathway (GO:0006957)5.40462869
27regulation of protein activation cascade (GO:2000257)5.39842995
28sulfur amino acid catabolic process (GO:0000098)5.38082458
29cysteine metabolic process (GO:0006534)5.36570090
30regulation of plasminogen activation (GO:0010755)5.30428591
31nitrogen cycle metabolic process (GO:0071941)5.28446332
32* negative regulation of fibrinolysis (GO:0051918)5.27718606
33* regulation of fibrinolysis (GO:0051917)5.19534205
34serine family amino acid catabolic process (GO:0009071)5.15896975
35ethanol metabolic process (GO:0006067)5.11307203
36bile acid metabolic process (GO:0008206)5.11124938
37regulation of complement activation (GO:0030449)5.03367814
38reverse cholesterol transport (GO:0043691)5.00783829
39aromatic amino acid family metabolic process (GO:0009072)4.99718761
40regulation of cholesterol esterification (GO:0010872)4.99531405
41alkaloid metabolic process (GO:0009820)4.95631904
42regulation of triglyceride catabolic process (GO:0010896)4.91578606
43protein-lipid complex remodeling (GO:0034368)4.89008656
44macromolecular complex remodeling (GO:0034367)4.89008656
45plasma lipoprotein particle remodeling (GO:0034369)4.89008656
46tyrosine metabolic process (GO:0006570)4.87265968
47S-adenosylmethionine metabolic process (GO:0046500)4.85337854
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84898590
49* negative regulation of hemostasis (GO:1900047)4.84712192
50* negative regulation of blood coagulation (GO:0030195)4.84712192
51homocysteine metabolic process (GO:0050667)4.78225583
52triglyceride homeostasis (GO:0070328)4.68760452
53acylglycerol homeostasis (GO:0055090)4.68760452
54alpha-amino acid catabolic process (GO:1901606)4.67413632
55phospholipid efflux (GO:0033700)4.67086113
56amino-acid betaine metabolic process (GO:0006577)4.63071577
57negative regulation of sterol transport (GO:0032372)4.62570934
58negative regulation of cholesterol transport (GO:0032375)4.62570934
59lysine catabolic process (GO:0006554)4.58301464
60lysine metabolic process (GO:0006553)4.58301464
61hormone catabolic process (GO:0042447)4.48701304
62cellular ketone body metabolic process (GO:0046950)4.47682948
63plasma lipoprotein particle clearance (GO:0034381)4.47038044
64glycine metabolic process (GO:0006544)4.44113556
65fat-soluble vitamin biosynthetic process (GO:0042362)4.43019699
66bile acid and bile salt transport (GO:0015721)4.41637957
67* negative regulation of coagulation (GO:0050819)4.39672996
68indolalkylamine metabolic process (GO:0006586)4.38742732
69coenzyme catabolic process (GO:0009109)4.38324502
70imidazole-containing compound metabolic process (GO:0052803)4.38196031
71* negative regulation of wound healing (GO:0061045)4.34126020
72polyketide metabolic process (GO:0030638)4.32570652
73doxorubicin metabolic process (GO:0044598)4.32570652
74daunorubicin metabolic process (GO:0044597)4.32570652
75cholesterol efflux (GO:0033344)4.30369122
76amine catabolic process (GO:0009310)4.30114251
77cellular biogenic amine catabolic process (GO:0042402)4.30114251
78cellular amino acid catabolic process (GO:0009063)4.29573298
79cellular glucuronidation (GO:0052695)4.27517504
80glutamate metabolic process (GO:0006536)4.27313928
81serine family amino acid metabolic process (GO:0009069)4.18926758
82benzene-containing compound metabolic process (GO:0042537)4.14667558
83arginine metabolic process (GO:0006525)4.09443157
84regulation of lipoprotein particle clearance (GO:0010984)4.08594603
85cellular modified amino acid catabolic process (GO:0042219)4.07824617
86intestinal cholesterol absorption (GO:0030299)4.07509116
87plasma lipoprotein particle assembly (GO:0034377)4.06105752
88dicarboxylic acid biosynthetic process (GO:0043650)4.05405114
89regulation of humoral immune response (GO:0002920)4.05285821
90ethanol oxidation (GO:0006069)4.04655337
91low-density lipoprotein particle remodeling (GO:0034374)4.04496346
92aldehyde catabolic process (GO:0046185)4.03564114
93serine family amino acid biosynthetic process (GO:0009070)4.03369739
94negative regulation of protein activation cascade (GO:2000258)4.02034951
95drug catabolic process (GO:0042737)3.99896759
96blood coagulation, intrinsic pathway (GO:0007597)3.94905368
97flavonoid metabolic process (GO:0009812)3.89440256
98primary alcohol catabolic process (GO:0034310)3.88582061
99positive regulation of lipoprotein lipase activity (GO:0051006)3.88105280
100positive regulation of triglyceride lipase activity (GO:0061365)3.88105280
101ketone body metabolic process (GO:1902224)3.87621565
102steroid catabolic process (GO:0006706)3.86569931
103aminoglycoside antibiotic metabolic process (GO:0030647)3.85342220
104negative regulation of lipase activity (GO:0060192)3.82780515
105cofactor catabolic process (GO:0051187)3.82191931
106complement activation, classical pathway (GO:0006958)3.81255726
107glucuronate metabolic process (GO:0019585)3.79303170
108uronic acid metabolic process (GO:0006063)3.79303170
109response to mercury ion (GO:0046689)3.78680214
110positive regulation of lipid catabolic process (GO:0050996)3.78446707
111cholesterol homeostasis (GO:0042632)3.78303250
112protein activation cascade (GO:0072376)3.77960344
113complement activation (GO:0006956)3.77607188
114phospholipid homeostasis (GO:0055091)3.77588424
115xenobiotic metabolic process (GO:0006805)3.77429902
116* fibrinolysis (GO:0042730)3.75051521
117regulation of bile acid biosynthetic process (GO:0070857)3.74855119
118organic acid catabolic process (GO:0016054)3.74763529
119carboxylic acid catabolic process (GO:0046395)3.74763529
120very-low-density lipoprotein particle assembly (GO:0034379)3.73169198
121sterol homeostasis (GO:0055092)3.71996346
122* positive regulation of blood coagulation (GO:0030194)3.71143291
123* positive regulation of hemostasis (GO:1900048)3.71143291
124plasma lipoprotein particle organization (GO:0071827)3.70574270
125negative regulation of fatty acid biosynthetic process (GO:0045717)3.68423896
126cytolysis (GO:0019835)3.68099086
127sodium-independent organic anion transport (GO:0043252)3.66007122
128regulation of cholesterol homeostasis (GO:2000188)3.65792861
129protein-lipid complex assembly (GO:0065005)3.63825450
130acetyl-CoA metabolic process (GO:0006084)3.63514333
131short-chain fatty acid metabolic process (GO:0046459)3.62780661
132acute-phase response (GO:0006953)3.59655429
133NAD biosynthetic process (GO:0009435)3.57746824
134L-methionine salvage (GO:0071267)3.57256541
135L-methionine biosynthetic process (GO:0071265)3.57256541
136amino acid salvage (GO:0043102)3.57256541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.40435153
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21214969
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98008946
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50767691
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.33432974
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.09214760
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86791489
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05771696
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03286421
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08137967
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0536112
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97964083
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95971666
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.60820515
15HTT_18923047_ChIP-ChIP_STHdh_Human1.55508876
16CLOCK_20551151_ChIP-Seq_293T_Human1.52978499
17GATA1_22025678_ChIP-Seq_K562_Human1.43024978
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39590584
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32671610
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19279430
21* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17789009
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16311340
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11615009
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05228428
25IRF1_19129219_ChIP-ChIP_H3396_Human1.04478043
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03167040
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00596073
28HNFA_21074721_ChIP-Seq_CACO-2_Human0.99937891
29CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99475493
30NFE2_27457419_Chip-Seq_LIVER_Mouse0.99385842
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94211025
32PHF8_20622853_ChIP-Seq_HELA_Human0.93886174
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91182343
34SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90570694
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86165686
36GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85214519
37EZH2_27294783_Chip-Seq_NPCs_Mouse0.84936997
38SOX2_21211035_ChIP-Seq_LN229_Human0.84208786
39IRF8_22096565_ChIP-ChIP_GC-B_Human0.83813646
40AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83721319
41RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83216424
42NFYA_21822215_ChIP-Seq_K562_Human0.83132105
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81366263
44ER_23166858_ChIP-Seq_MCF-7_Human0.79777200
45GATA6_21074721_ChIP-Seq_CACO-2_Human0.79682211
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79242191
47TRIM28_21343339_ChIP-Seq_HEK293_Human0.79061568
48GATA4_25053715_ChIP-Seq_YYC3_Human0.78710961
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78028112
50IGF1R_20145208_ChIP-Seq_DFB_Human0.77398789
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77153990
52TP53_18474530_ChIP-ChIP_U2OS_Human0.76212390
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75996850
54KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75122230
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74863187
56SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73996939
57CBX2_22325352_ChIP-Seq_293T-Rex_Human0.71689139
58* RARA_24833708_ChIP-Seq_LIVER_Mouse0.71581412
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71182968
60ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71126667
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70940627
62ZNF263_19887448_ChIP-Seq_K562_Human0.70401733
63* PIAS1_25552417_ChIP-Seq_VCAP_Human0.69605771
64KLF5_20875108_ChIP-Seq_MESCs_Mouse0.68324490
65CRX_20693478_ChIP-Seq_RETINA_Mouse0.66860032
66ETV1_20927104_ChIP-Seq_GIST48_Human0.66323652
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66171411
68RAC3_21632823_ChIP-Seq_H3396_Human0.66070440
69ESR2_21235772_ChIP-Seq_MCF-7_Human0.65752456
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.65411071
71PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65308048
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64418842
73RARB_24833708_ChIP-Seq_LIVER_Mouse0.63582170
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63463697
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63463697
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63314133
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63308909
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62922586
79* FOXH1_21741376_ChIP-Seq_EPCs_Human0.62862884
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.61435551
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60750049
82* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60513119
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60345456
84OCT4_21477851_ChIP-Seq_ESCs_Mouse0.60089643
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60065416
86* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59748500
87NFYB_21822215_ChIP-Seq_K562_Human0.59025439
88SMAD1_18555785_Chip-Seq_ESCs_Mouse0.58987272
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.58887682
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.58661777
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.58484604
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.58288452
93CBP_20019798_ChIP-Seq_JUKART_Human0.58288452
94ESRRB_18555785_Chip-Seq_ESCs_Mouse0.57280602
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.56877778
96CDX2_22108803_ChIP-Seq_LS180_Human0.56614677
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.56075223
98RBPJ_21746931_ChIP-Seq_IB4_Human0.55733470
99LXR_22292898_ChIP-Seq_THP-1_Human0.55218633
100EGR1_19032775_ChIP-ChIP_M12_Human0.54346184
101SOX2_20726797_ChIP-Seq_SW620_Human0.54158518
102* CEBPB_22108803_ChIP-Seq_LS180_Human0.54034018
103SPI1_20517297_ChIP-Seq_HL60_Human0.53823056
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52544593
105FOXA1_25552417_ChIP-Seq_VCAP_Human0.52200854
106AR_20517297_ChIP-Seq_VCAP_Human0.51817067
107MYC_19915707_ChIP-ChIP_AK7_Human0.51356884
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51075559
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50474558
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49842499
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49544568
112CBP_21632823_ChIP-Seq_H3396_Human0.47589057
113P53_21459846_ChIP-Seq_SAOS-2_Human0.46723334
114* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45312600
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44981516
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.44130475
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43642168
118* STAT1_17558387_ChIP-Seq_HELA_Human0.43520744
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42954697
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.42797048
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.42461063
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42355953
123TAF2_19829295_ChIP-Seq_ESCs_Human0.42291420
124TAF15_26573619_Chip-Seq_HEK293_Human0.42195879
125GATA1_19941826_ChIP-Seq_K562_Human0.41901462
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.40523905
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.39814987
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39479210
129GATA2_19941826_ChIP-Seq_K562_Human0.39420695
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38842960
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.38548292
132BCAT_22108803_ChIP-Seq_LS180_Human0.38117298
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38100564
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38046606
135GATA6_25053715_ChIP-Seq_YYC3_Human0.37646273
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.37617589
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.37148710
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35837147
139SPI1_26923725_Chip-Seq_HPCs_Mouse0.35328130
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34373498
141CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33826238
142NCOR_22424771_ChIP-Seq_293T_Human0.33649680
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.33626208
144ERG_20517297_ChIP-Seq_VCAP_Human0.33162959
145OCT4_20526341_ChIP-Seq_ESCs_Human0.32798431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27622477
2MP0005360_urolithiasis7.54418405
3MP0005085_abnormal_gallbladder_physiolo6.44610124
4MP0005365_abnormal_bile_salt6.17428165
5MP0008875_abnormal_xenobiotic_pharmacok5.19748666
6MP0003806_abnormal_nucleotide_metabolis4.22280354
7MP0003252_abnormal_bile_duct3.89081922
8MP0010329_abnormal_lipoprotein_level3.60879252
9MP0009840_abnormal_foam_cell3.36309906
10MP0005083_abnormal_biliary_tract3.09163330
11MP0003195_calcinosis2.84088918
12MP0005332_abnormal_amino_acid2.76321650
13MP0001666_abnormal_nutrient_absorption2.58672094
14MP0003191_abnormal_cellular_cholesterol2.42889549
15MP0000609_abnormal_liver_physiology2.17020997
16MP0004019_abnormal_vitamin_homeostasis2.12264507
17MP0002118_abnormal_lipid_homeostasis2.10445711
18MP0002138_abnormal_hepatobiliary_system1.95745812
19MP0003868_abnormal_feces_composition1.93554730
20MP0005319_abnormal_enzyme/_coenzyme1.83515637
21MP0001764_abnormal_homeostasis1.68031217
22MP0009697_abnormal_copulation1.58735445
23MP0005584_abnormal_enzyme/coenzyme_acti1.57147547
24MP0005451_abnormal_body_composition1.45751254
25MP0003011_delayed_dark_adaptation1.41919983
26MP0003656_abnormal_erythrocyte_physiolo1.29097108
27MP0003186_abnormal_redox_activity1.25731206
28MP0009643_abnormal_urine_homeostasis1.22123447
29MP0000598_abnormal_liver_morphology1.18656036
30MP0003705_abnormal_hypodermis_morpholog1.16915457
31MP0005647_abnormal_sex_gland1.13073514
32MP0000604_amyloidosis1.10872969
33MP0009764_decreased_sensitivity_to1.06738544
34MP0002254_reproductive_system_inflammat1.02950653
35MP0009763_increased_sensitivity_to1.02914371
36MP0010368_abnormal_lymphatic_system0.98309162
37MP0005636_abnormal_mineral_homeostasis0.91460456
38MP0005187_abnormal_penis_morphology0.89505035
39* MP0008469_abnormal_protein_level0.86624126
40* MP0009642_abnormal_blood_homeostasis0.86485022
41MP0005408_hypopigmentation0.84328975
42MP0006036_abnormal_mitochondrial_physio0.81195985
43MP0005670_abnormal_white_adipose0.80590529
44MP0005376_homeostasis/metabolism_phenot0.80520323
45MP0009765_abnormal_xenobiotic_induced0.79222847
46MP0002078_abnormal_glucose_homeostasis0.77493299
47MP0002876_abnormal_thyroid_physiology0.76060417
48MP0005084_abnormal_gallbladder_morpholo0.75590724
49MP0001915_intracranial_hemorrhage0.74036021
50MP0005220_abnormal_exocrine_pancreas0.71591393
51MP0002971_abnormal_brown_adipose0.71367518
52MP0003690_abnormal_glial_cell0.68879746
53MP0003879_abnormal_hair_cell0.68779052
54MP0004130_abnormal_muscle_cell0.68440664
55MP0005334_abnormal_fat_pad0.68205943
56MP0001661_extended_life_span0.67617885
57MP0005535_abnormal_body_temperature0.66962448
58MP0009053_abnormal_anal_canal0.66437988
59MP0005266_abnormal_metabolism0.64233779
60MP0003329_amyloid_beta_deposits0.63652979
61MP0000639_abnormal_adrenal_gland0.62241441
62MP0001756_abnormal_urination0.58473920
63MP0002282_abnormal_trachea_morphology0.56891828
64MP0006035_abnormal_mitochondrial_morpho0.55849017
65MP0005448_abnormal_energy_balance0.55662826
66MP0005464_abnormal_platelet_physiology0.55399761
67MP0002822_catalepsy0.51119391
68MP0005395_other_phenotype0.49345310
69MP0008874_decreased_physiological_sensi0.47140147
70MP0003638_abnormal_response/metabolism_0.46779037
71MP0003718_maternal_effect0.45928135
72MP0008873_increased_physiological_sensi0.45136280
73MP0004782_abnormal_surfactant_physiolog0.44917818
74MP0002928_abnormal_bile_duct0.44225113
75MP0003436_decreased_susceptibility_to0.44172991
76MP0002136_abnormal_kidney_physiology0.43992679
77MP0002249_abnormal_larynx_morphology0.43917363
78MP0003724_increased_susceptibility_to0.42410643
79MP0003075_altered_response_to0.41642799
80MP0002837_dystrophic_cardiac_calcinosis0.41178311
81MP0003959_abnormal_lean_body0.40687574
82MP0008872_abnormal_physiological_respon0.40416842
83MP0005248_abnormal_Harderian_gland0.40339085
84MP0003953_abnormal_hormone_level0.40153227
85MP0004381_abnormal_hair_follicle0.38590428
86MP0005166_decreased_susceptibility_to0.38564841
87MP0005023_abnormal_wound_healing0.37502347
88MP0009672_abnormal_birth_weight0.36761411
89MP0005666_abnormal_adipose_tissue0.36529307
90MP0009785_altered_susceptibility_to0.35395625
91MP0000579_abnormal_nail_morphology0.34795842
92MP0004883_abnormal_blood_vessel0.34681373
93MP0000566_synostosis0.33825236
94MP0000249_abnormal_blood_vessel0.33401380
95MP0009115_abnormal_fat_cell0.32650120
96MP0001243_abnormal_dermal_layer0.32438969
97MP0002796_impaired_skin_barrier0.32371455
98MP0006082_CNS_inflammation0.31018064
99MP0002168_other_aberrant_phenotype0.30996956
100MP0000230_abnormal_systemic_arterial0.30858747
101MP0009384_cardiac_valve_regurgitation0.30446115
102MP0001853_heart_inflammation0.30401778
103MP0002970_abnormal_white_adipose0.30086135
104MP0001845_abnormal_inflammatory_respons0.28333723
105MP0001881_abnormal_mammary_gland0.27217353
106MP0005164_abnormal_response_to0.26784549
107MP0004142_abnormal_muscle_tone0.26216268
108MP0005197_abnormal_uvea_morphology0.25367548
109MP0002132_abnormal_respiratory_system0.24897785
110MP0002090_abnormal_vision0.24694105
111MP0005058_abnormal_lysosome_morphology0.23504810
112MP0000467_abnormal_esophagus_morphology0.23112469
113MP0001986_abnormal_taste_sensitivity0.22616357
114MP0010386_abnormal_urinary_bladder0.19585813
115MP0001944_abnormal_pancreas_morphology0.18489182
116MP0003632_abnormal_nervous_system0.18482306
117MP0005646_abnormal_pituitary_gland0.17521283
118MP0001851_eye_inflammation0.17015577

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.52753103
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47218062
3Intrahepatic cholestasis (HP:0001406)7.25455290
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.72692389
5Prolonged partial thromboplastin time (HP:0003645)6.66575613
6Hypobetalipoproteinemia (HP:0003563)6.43755229
7Xanthomatosis (HP:0000991)6.29167720
8Hyperlipoproteinemia (HP:0010980)5.68289938
9Complement deficiency (HP:0004431)5.43253619
10Joint hemorrhage (HP:0005261)4.89149176
11Hypolipoproteinemia (HP:0010981)4.86373853
12Hyperammonemia (HP:0001987)4.62080264
13Abnormality of the common coagulation pathway (HP:0010990)4.52839534
14Epidermoid cyst (HP:0200040)4.47341694
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44595122
16Hyperglycinemia (HP:0002154)4.38749360
17Abnormality of methionine metabolism (HP:0010901)4.32739040
18Hypoalphalipoproteinemia (HP:0003233)4.30430845
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.27019435
20Ketosis (HP:0001946)4.26063775
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14073931
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12848088
23Fat malabsorption (HP:0002630)4.08723141
24Abnormality of complement system (HP:0005339)3.96629326
25Abnormality of pyrimidine metabolism (HP:0004353)3.88382760
26Abnormality of serine family amino acid metabolism (HP:0010894)3.86795126
27Abnormality of glycine metabolism (HP:0010895)3.86795126
28Hyperglycinuria (HP:0003108)3.86728049
29Hypoglycemic coma (HP:0001325)3.82029317
30Abnormality of the intrinsic pathway (HP:0010989)3.80853925
31Conjugated hyperbilirubinemia (HP:0002908)3.68690958
32Hypercholesterolemia (HP:0003124)3.61262110
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35578801
34Hyperbilirubinemia (HP:0002904)3.33213764
35Abnormality of fatty-acid metabolism (HP:0004359)3.31625798
36Spontaneous abortion (HP:0005268)3.12431513
37Osteomalacia (HP:0002749)3.10091244
38Delayed CNS myelination (HP:0002188)3.09740676
39Steatorrhea (HP:0002570)3.09708812
40Abnormality of nucleobase metabolism (HP:0010932)3.06134609
41Abnormality of serum amino acid levels (HP:0003112)3.05847574
42Hypochromic microcytic anemia (HP:0004840)2.99882125
43Hepatocellular carcinoma (HP:0001402)2.98449476
44Ketoacidosis (HP:0001993)2.95404682
45Myocardial infarction (HP:0001658)2.93395110
46Reduced antithrombin III activity (HP:0001976)2.82779689
47Systemic lupus erythematosus (HP:0002725)2.76873640
48Skin nodule (HP:0200036)2.76638148
49Metabolic acidosis (HP:0001942)2.74916011
50Abnormality of purine metabolism (HP:0004352)2.65010533
51Lethargy (HP:0001254)2.59860387
52Vascular calcification (HP:0004934)2.56673969
53Dicarboxylic aciduria (HP:0003215)2.55832253
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55832253
55Purpura (HP:0000979)2.53493880
56Fair hair (HP:0002286)2.52604184
57Hyperphosphaturia (HP:0003109)2.51605477
58Glomerulonephritis (HP:0000099)2.51337507
59Acanthocytosis (HP:0001927)2.50656587
60Spastic diplegia (HP:0001264)2.45960620
61Abnormal gallbladder morphology (HP:0012437)2.45238990
62Hypoglycemic seizures (HP:0002173)2.43622981
63Gout (HP:0001997)2.42851794
64Mitral stenosis (HP:0001718)2.42823714
65Cerebral edema (HP:0002181)2.42769439
66Glycosuria (HP:0003076)2.41737392
67Abnormality of urine glucose concentration (HP:0011016)2.41737392
68Pulmonary embolism (HP:0002204)2.40676760
69Cholelithiasis (HP:0001081)2.39289969
70Amyloidosis (HP:0011034)2.38409032
71Recurrent gram-negative bacterial infections (HP:0005420)2.38320932
72Irritability (HP:0000737)2.35703830
73Neonatal onset (HP:0003623)2.35582192
74Abnormal gallbladder physiology (HP:0012438)2.34775528
75Cholecystitis (HP:0001082)2.34775528
76Bifid scrotum (HP:0000048)2.28221465
77Gingival bleeding (HP:0000225)2.27736239
78Cardiovascular calcification (HP:0011915)2.27539403
79Arthropathy (HP:0003040)2.23400424
80Malnutrition (HP:0004395)2.21595581
81Esophageal varix (HP:0002040)2.21134866
82Menorrhagia (HP:0000132)2.19818491
83Pancreatitis (HP:0001733)2.14294926
84Thrombophlebitis (HP:0004418)2.13238712
85Brushfield spots (HP:0001088)2.12132622
86Sensorimotor neuropathy (HP:0007141)2.11455280
87Enlarged kidneys (HP:0000105)2.11185241
88Late onset (HP:0003584)2.09647017
89Bile duct proliferation (HP:0001408)2.07101117
90Abnormal biliary tract physiology (HP:0012439)2.07101117
91Vomiting (HP:0002013)2.05988487
92Abnormality of the Achilles tendon (HP:0005109)2.05831155
93Neonatal hypoglycemia (HP:0001998)2.02788877
94Opisthotonus (HP:0002179)2.02720114
95Abnormal urine phosphate concentration (HP:0012599)2.01767444
96Hemorrhage of the eye (HP:0011885)2.01333382
97Generalized aminoaciduria (HP:0002909)2.01157107
98Abnormality of the gallbladder (HP:0005264)1.99447646
99Poikilocytosis (HP:0004447)1.99366514
100Elevated alkaline phosphatase (HP:0003155)1.98622463
101Hyperinsulinemic hypoglycemia (HP:0000825)1.96894846
102Rickets (HP:0002748)1.91844663
103Abnormality of iron homeostasis (HP:0011031)1.91681455
104Abnormality of transition element cation homeostasis (HP:0011030)1.87717588
105Abnormal cartilage morphology (HP:0002763)1.86296114
106Hypophosphatemic rickets (HP:0004912)1.86160246
107Increased mean platelet volume (HP:0011877)1.82492410
108Renal cortical cysts (HP:0000803)1.82428603
109Abnormality of proline metabolism (HP:0010907)1.81472248
110Hydroxyprolinuria (HP:0003080)1.81472248
111Alkalosis (HP:0001948)1.80787890
112Elevated hepatic transaminases (HP:0002910)1.80722219
113Status epilepticus (HP:0002133)1.80246395
114Abnormality of alkaline phosphatase activity (HP:0004379)1.79370937
115Gangrene (HP:0100758)1.79251016
116Abnormal enzyme/coenzyme activity (HP:0012379)1.78984827
117Nephritis (HP:0000123)1.77743474
118Generalized hypopigmentation of hair (HP:0011358)1.72522941
119Joint swelling (HP:0001386)1.72120167
120Hyperglycemia (HP:0003074)1.72040075
121Abnormality of vitamin metabolism (HP:0100508)1.71688411
122Increased serum ferritin (HP:0003281)1.71319852
123Abnormal platelet volume (HP:0011876)1.62964749
124Retinal atrophy (HP:0001105)1.62885804
125Atrioventricular block (HP:0001678)1.61132258
126Hypochromic anemia (HP:0001931)1.60274737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.26624890
2FGFR44.68987768
3ERN14.53973008
4SIK14.51038936
5TAOK33.07541376
6INSRR2.95806820
7ERBB42.88589085
8PIK3CA2.60835152
9MAP2K42.39222243
10PKN22.20869510
11NTRK32.14302312
12MST1R2.08248039
13MAP3K121.89803349
14FLT31.88839538
15MAPK111.87834210
16TRIB31.82490995
17PIK3CG1.79009171
18TYK21.70377620
19LATS11.61856291
20WNK31.61384983
21DAPK21.52334726
22ABL21.48182912
23PTK61.46722551
24NEK91.37784699
25FGFR21.36837690
26KDR1.33232243
27FRK1.30498938
28MYLK1.23256211
29JAK21.22071794
30PRPF4B1.19638488
31MAP3K71.19445606
32PINK11.13419930
33PRKG11.11748356
34GRK61.11555575
35PRKACA1.11352416
36PRKAA21.10461586
37MAP2K31.10032233
38CASK1.07946451
39TBK11.05964550
40TNK21.05455613
41ERBB21.02989605
42CSNK1D1.02323505
43JAK11.01843193
44MAP3K21.00134732
45MAPK40.99552204
46MAP3K100.97946290
47MAP3K140.94129482
48CAMKK20.93280044
49PRKCZ0.92851994
50MUSK0.91524148
51EPHB10.89690794
52NLK0.89182916
53MET0.84498386
54ACVR1B0.84178997
55MAP3K30.83660136
56MAPK120.83401412
57STK38L0.83222906
58MAP3K110.82620162
59MAPK150.81383399
60EPHA30.81313136
61PRKCB0.80396638
62CDK60.79890992
63TIE10.77915653
64MAPKAPK30.77549462
65PRKACG0.76220054
66FER0.73982474
67DYRK1B0.71460526
68CAMK2G0.71403800
69CSK0.70585781
70MAP2K60.69700221
71SGK10.67458719
72RPS6KA30.66714767
73GSK3A0.66657915
74CAMK1D0.65023984
75EIF2AK10.64225667
76PRKAA10.63280375
77SGK30.62270990
78ZAP700.60639121
79TGFBR20.60388413
80MAPK70.59993122
81RIPK10.58506547
82IRAK30.58385172
83STK380.58216954
84FGFR30.57514493
85BCR0.56768945
86CSF1R0.56749156
87PTK20.56419425
88CSNK1E0.55203146
89IKBKE0.54690442
90STK160.53627368
91PRKACB0.53522647
92EPHA40.51575490
93PDPK10.51188342
94MAP4K20.50713115
95CSNK1A10.50436283
96PRKCQ0.50195502
97CSNK2A10.49865944
98TAOK20.49776273
99PRKCE0.49288584
100CSNK1G10.48070629
101PIM20.47980976
102SRC0.45723916
103MAP3K50.44653766
104SGK20.44352772
105GRK10.43988823
106ADRBK20.43966711
107IGF1R0.42908874
108RET0.42223834
109PRKCG0.42192252
110ICK0.41671533
111MAP2K10.41579390
112CDK40.41363517
113CSNK2A20.41276870
114MAP3K130.40533946
115PDK20.39496942
116PKN10.39027610
117MAP3K60.38229859
118CAMKK10.36480594
119MTOR0.35105653
120EGFR0.33913726
121KSR20.33574658
122CAMK40.33495561
123MAP3K10.32094279
124PBK0.31830422
125BLK0.31274114
126SGK4940.30905349
127SGK2230.30905349
128PDK10.30737874
129CSNK1G20.28001415
130LATS20.27550720
131IRAK10.26205619
132PRKCA0.25920405
133CSNK1G30.25268636
134IRAK20.24417835
135MAP2K20.21427179
136ABL10.20752371
137BMX0.20154735
138PAK30.20070095
139CAMK1G0.19907158
140MAPK30.17961213

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53266838
2Nitrogen metabolism_Homo sapiens_hsa009103.60612899
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44475159
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33841881
5Arginine biosynthesis_Homo sapiens_hsa002203.11013241
6Complement and coagulation cascades_Homo sapiens_hsa046102.81350561
7Tryptophan metabolism_Homo sapiens_hsa003802.69356862
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67882433
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62229934
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55599085
11Fatty acid degradation_Homo sapiens_hsa000712.46605534
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36297412
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24112826
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14421953
15Butanoate metabolism_Homo sapiens_hsa006502.12899212
16Peroxisome_Homo sapiens_hsa041462.05889429
17Chemical carcinogenesis_Homo sapiens_hsa052041.96222396
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.95065036
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93715144
20Histidine metabolism_Homo sapiens_hsa003401.89690319
21Propanoate metabolism_Homo sapiens_hsa006401.89559260
22PPAR signaling pathway_Homo sapiens_hsa033201.86064595
23Caffeine metabolism_Homo sapiens_hsa002321.82434502
24Staphylococcus aureus infection_Homo sapiens_hsa051501.79172732
25Fatty acid metabolism_Homo sapiens_hsa012121.78905283
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.76254255
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75889407
28Retinol metabolism_Homo sapiens_hsa008301.70817929
29beta-Alanine metabolism_Homo sapiens_hsa004101.69764998
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64699005
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59712903
32Selenocompound metabolism_Homo sapiens_hsa004501.57490418
33Phenylalanine metabolism_Homo sapiens_hsa003601.57478084
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52621182
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51918777
36Bile secretion_Homo sapiens_hsa049761.48919071
37Tyrosine metabolism_Homo sapiens_hsa003501.44913563
38Pyruvate metabolism_Homo sapiens_hsa006201.34434764
39Sulfur metabolism_Homo sapiens_hsa009201.34088627
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.33866268
41Fatty acid elongation_Homo sapiens_hsa000621.32324345
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26856869
43Folate biosynthesis_Homo sapiens_hsa007901.21271756
44Biosynthesis of amino acids_Homo sapiens_hsa012301.21140756
45Steroid biosynthesis_Homo sapiens_hsa001001.20191246
46ABC transporters_Homo sapiens_hsa020101.18790608
47Fat digestion and absorption_Homo sapiens_hsa049751.16591012
48Carbon metabolism_Homo sapiens_hsa012001.11223415
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02895368
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.99971148
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.97853762
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97671500
53Arginine and proline metabolism_Homo sapiens_hsa003300.96067984
54Sulfur relay system_Homo sapiens_hsa041220.95176234
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94291290
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87264137
57Vitamin digestion and absorption_Homo sapiens_hsa049770.85294773
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83691193
59Lysine degradation_Homo sapiens_hsa003100.80025065
60One carbon pool by folate_Homo sapiens_hsa006700.75903455
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68584417
62Glycerolipid metabolism_Homo sapiens_hsa005610.65929768
63Glutathione metabolism_Homo sapiens_hsa004800.63965543
64Pentose phosphate pathway_Homo sapiens_hsa000300.56430714
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51336268
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45666519
67Metabolic pathways_Homo sapiens_hsa011000.45645233
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37468990
69Prion diseases_Homo sapiens_hsa050200.36886804
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25361529
71Galactose metabolism_Homo sapiens_hsa000520.24803858
72Linoleic acid metabolism_Homo sapiens_hsa005910.24390855
73Fructose and mannose metabolism_Homo sapiens_hsa000510.23100524
74Insulin resistance_Homo sapiens_hsa049310.22930879
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.21708257
76Pertussis_Homo sapiens_hsa051330.20950047
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18938769
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15977877
79Glucagon signaling pathway_Homo sapiens_hsa049220.09828505
80AMPK signaling pathway_Homo sapiens_hsa041520.01871679
81Serotonergic synapse_Homo sapiens_hsa047260.00720297
82Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2613365
83N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2458027
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2420878
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2410657
86Amoebiasis_Homo sapiens_hsa05146-0.2395456
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2358929
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2255026
89Circadian rhythm_Homo sapiens_hsa04710-0.2251111
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1951312
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1923827
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1896682
93Hepatitis C_Homo sapiens_hsa05160-0.1779361
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1718620
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.1644585
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1636804
97Sphingolipid metabolism_Homo sapiens_hsa00600-0.1626955
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1622202
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1509723
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1469487
101Regulation of autophagy_Homo sapiens_hsa04140-0.1381295
102African trypanosomiasis_Homo sapiens_hsa05143-0.1278474
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1033880
104Mineral absorption_Homo sapiens_hsa04978-0.0997858
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0812681
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0781769
107Other glycan degradation_Homo sapiens_hsa00511-0.0677329
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0587886
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0423119

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