HRCT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.37310412
2vascular endothelial growth factor signaling pathway (GO:0038084)6.59650764
3retina vasculature morphogenesis in camera-type eye (GO:0061299)5.71341385
4endothelium development (GO:0003158)5.13198919
5cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.10740068
6low-density lipoprotein particle clearance (GO:0034383)4.89806966
7transcytosis (GO:0045056)4.87651052
8regulation of sequestering of triglyceride (GO:0010889)4.83270509
9NADH metabolic process (GO:0006734)4.72846525
10vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.47166030
11lymphangiogenesis (GO:0001946)4.45389871
12protein heterotrimerization (GO:0070208)4.18778517
13urea cycle (GO:0000050)4.01915351
14ethanol oxidation (GO:0006069)3.97618707
15heart trabecula formation (GO:0060347)3.93473433
16urea metabolic process (GO:0019627)3.89461854
17barbed-end actin filament capping (GO:0051016)3.83363808
18regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.74253315
19positive regulation of lipoprotein lipase activity (GO:0051006)3.71333089
20positive regulation of triglyceride lipase activity (GO:0061365)3.71333089
21positive regulation of fatty acid oxidation (GO:0046321)3.70947174
22atrioventricular valve morphogenesis (GO:0003181)3.70912046
23glomerular filtration (GO:0003094)3.65727703
24cGMP-mediated signaling (GO:0019934)3.63559387
25positive regulation of endothelial cell apoptotic process (GO:2000353)3.61803483
26nitrogen cycle metabolic process (GO:0071941)3.61126029
27endothelial cell morphogenesis (GO:0001886)3.56056523
28white fat cell differentiation (GO:0050872)3.55820643
29brown fat cell differentiation (GO:0050873)3.55388540
30cell migration involved in heart development (GO:0060973)3.53230952
31intestinal absorption (GO:0050892)3.48759222
32cell adhesion mediated by integrin (GO:0033627)3.47772579
33desmosome organization (GO:0002934)3.46482897
34renal filtration (GO:0097205)3.43259848
35diacylglycerol metabolic process (GO:0046339)3.40862535
36cellular response to vitamin (GO:0071295)3.37452464
37morphogenesis of an endothelium (GO:0003159)3.30801291
38endothelial tube morphogenesis (GO:0061154)3.30801291
39substrate-dependent cell migration (GO:0006929)3.29722475
40ethanol metabolic process (GO:0006067)3.29322602
41basement membrane organization (GO:0071711)3.27460609
42sprouting angiogenesis (GO:0002040)3.25481354
43phagocytosis, recognition (GO:0006910)3.24904821
44Notch signaling involved in heart development (GO:0061314)3.24135610
45endothelial cell differentiation (GO:0045446)3.23202353
46regulation of endothelial cell differentiation (GO:0045601)3.22524912
47regulation of cholesterol storage (GO:0010885)3.21966571
48fatty acid transmembrane transport (GO:1902001)3.20911070
49lipid particle organization (GO:0034389)3.18053005
50cellular glucuronidation (GO:0052695)3.17294468
51smooth muscle tissue development (GO:0048745)3.16183576
52blood vessel endothelial cell migration (GO:0043534)3.14478220
53regulation of plasminogen activation (GO:0010755)3.13555041
54blood vessel maturation (GO:0001955)3.12895120
55regulation of vasculogenesis (GO:2001212)3.09475831
56renal system process involved in regulation of blood volume (GO:0001977)3.08758586
57polyketide metabolic process (GO:0030638)3.07725587
58doxorubicin metabolic process (GO:0044598)3.07725587
59daunorubicin metabolic process (GO:0044597)3.07725587
60surfactant homeostasis (GO:0043129)3.06712028
61protein retention in ER lumen (GO:0006621)3.06088649
62positive regulation of smooth muscle cell migration (GO:0014911)3.05764744
63ovulation from ovarian follicle (GO:0001542)3.04344684
64glycerolipid catabolic process (GO:0046503)3.02747976
65patterning of blood vessels (GO:0001569)3.02253804
66primary alcohol catabolic process (GO:0034310)2.98176578
67positive regulation of lipid catabolic process (GO:0050996)2.97542399
68positive regulation of receptor recycling (GO:0001921)2.95097373
69triglyceride catabolic process (GO:0019433)2.94736716
70glucuronate metabolic process (GO:0019585)2.93628942
71uronic acid metabolic process (GO:0006063)2.93628942
72negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93484381
73regulation of fatty acid oxidation (GO:0046320)2.92439736
74induction of positive chemotaxis (GO:0050930)2.92173567
75glomerular basement membrane development (GO:0032836)2.91976568
76cell migration involved in sprouting angiogenesis (GO:0002042)2.89423521
77primary alcohol metabolic process (GO:0034308)2.88653395
78positive regulation of pseudopodium assembly (GO:0031274)2.88587935
79regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87802512
80potassium ion import (GO:0010107)2.87037205
81peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86949297
82hemidesmosome assembly (GO:0031581)2.85702123
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83569347
84trabecula formation (GO:0060343)2.83101784
85cardiac epithelial to mesenchymal transition (GO:0060317)2.82905270
86endocardial cushion morphogenesis (GO:0003203)2.82624978
87glomerular visceral epithelial cell development (GO:0072015)2.81781165
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.81531635
89positive regulation of vasculogenesis (GO:2001214)2.81328251
90endothelial cell proliferation (GO:0001935)2.81161201
91extracellular fibril organization (GO:0043206)2.80117153
92regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.78421331
93glomerulus development (GO:0032835)2.76951333
94endothelial cell chemotaxis (GO:0035767)2.76643959
95regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.75648381
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75510355
97L-phenylalanine metabolic process (GO:0006558)2.75510355
98carnitine shuttle (GO:0006853)2.75400691
99cellular response to nutrient (GO:0031670)2.73132781
100positive regulation of fatty acid beta-oxidation (GO:0032000)2.73047390
101negative regulation of blood vessel endothelial cell migration (GO:0043537)2.72983242
102mesenchymal cell development (GO:0014031)2.72708067
103oxaloacetate metabolic process (GO:0006107)2.72595841
104cardiac myofibril assembly (GO:0055003)2.72463287
105regulation of metalloenzyme activity (GO:0048552)2.70713394
106regulation of endothelial cell apoptotic process (GO:2000351)2.68954712
107negative regulation of Rho protein signal transduction (GO:0035024)2.68715697
108epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66950038
109negative regulation of catenin import into nucleus (GO:0035414)2.66361735
110stress fiber assembly (GO:0043149)2.66004100
111blood vessel remodeling (GO:0001974)2.65954970
112actin filament depolymerization (GO:0030042)2.64488782
113aminoglycoside antibiotic metabolic process (GO:0030647)2.64476752
114sulfur amino acid catabolic process (GO:0000098)2.64025090
115regulation of integrin-mediated signaling pathway (GO:2001044)2.63940425
116fibril organization (GO:0097435)2.63739478
117heart valve morphogenesis (GO:0003179)2.63568573
118cardiac muscle cell proliferation (GO:0060038)2.63560273
119positive regulation of endothelial cell migration (GO:0010595)2.63299106
120positive regulation of extracellular matrix organization (GO:1903055)2.62827692
121protein carboxylation (GO:0018214)2.62580261
122peptidyl-glutamic acid carboxylation (GO:0017187)2.62580261
123regulation of lipoprotein metabolic process (GO:0050746)2.62372093
124renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.62170252
125positive regulation of macrophage cytokine production (GO:0060907)2.61184948
126regulation of pseudopodium assembly (GO:0031272)2.60598407
127cell-substrate junction assembly (GO:0007044)2.59826585
128positive regulation of fatty acid metabolic process (GO:0045923)2.59786523
129regulation of apoptotic process involved in morphogenesis (GO:1902337)2.59528742
130plasma membrane repair (GO:0001778)2.59174684
131bile acid and bile salt transport (GO:0015721)2.58236063
132vasculogenesis (GO:0001570)2.57311728
133embryonic heart tube development (GO:0035050)2.56705214
134GDP-mannose metabolic process (GO:0019673)2.56280391
135acylglycerol catabolic process (GO:0046464)2.55649493
136neutral lipid catabolic process (GO:0046461)2.55649493
137L-serine transport (GO:0015825)2.53970536
138aorta morphogenesis (GO:0035909)2.53459244
139negative regulation of endothelial cell migration (GO:0010596)2.53347750
140regulation of positive chemotaxis (GO:0050926)2.52851383
141regulation of macrophage cytokine production (GO:0010935)2.52251838
142triglyceride metabolic process (GO:0006641)2.52211040
143arginine metabolic process (GO:0006525)2.51651003
144chemical homeostasis within a tissue (GO:0048875)2.51605954
145adhesion of symbiont to host (GO:0044406)2.51239339
146positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.50222301
147arginine catabolic process (GO:0006527)2.50049627
148sarcomere organization (GO:0045214)2.49217192
149protein localization to cell surface (GO:0034394)2.49118327
150endodermal cell differentiation (GO:0035987)2.48657413
151ventricular septum morphogenesis (GO:0060412)2.48637274
152virion attachment to host cell (GO:0019062)2.47610054
153adhesion of symbiont to host cell (GO:0044650)2.47610054
154peptidyl-tyrosine autophosphorylation (GO:0038083)2.47502394
155regulation of tight junction assembly (GO:2000810)2.47340350
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46329652
157cell proliferation involved in kidney development (GO:0072111)2.46247096
158collagen fibril organization (GO:0030199)2.45898183
159nucleoside diphosphate biosynthetic process (GO:0009133)2.45842699
160protein targeting to plasma membrane (GO:0072661)2.45814846
161blood vessel morphogenesis (GO:0048514)2.45426488
162fatty acid beta-oxidation (GO:0006635)2.45057441
163regulation of endothelial cell migration (GO:0010594)2.44937114
164apoptotic cell clearance (GO:0043277)2.43979802
165regulation of triglyceride catabolic process (GO:0010896)2.43703404
166negative regulation of cartilage development (GO:0061037)2.43673178
167negative regulation of fatty acid transport (GO:2000192)2.43285210
168receptor guanylyl cyclase signaling pathway (GO:0007168)2.42295445
169positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41236386
170nucleotide-sugar biosynthetic process (GO:0009226)2.40735514
171acylglycerol homeostasis (GO:0055090)2.40216536
172triglyceride homeostasis (GO:0070328)2.40216536
173fatty acid catabolic process (GO:0009062)2.38937491
174glycerol metabolic process (GO:0006071)2.38401338
175chondrocyte proliferation (GO:0035988)2.36827113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.83659549
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.69805799
3CLOCK_20551151_ChIP-Seq_293T_Human4.02645771
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.65047143
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.63900476
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.05299270
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.00652750
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.60431816
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.47005775
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.40176745
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35467300
12CJUN_26792858_Chip-Seq_BT549_Human2.17377669
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17135111
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13261736
15LXR_22292898_ChIP-Seq_THP-1_Human2.11686347
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.10489854
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.07832466
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.00432776
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.98282908
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92361625
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.85557862
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.82944686
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.82944686
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82156545
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.72759539
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72662079
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72364707
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69662073
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.68983351
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.68158930
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.67718860
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.63810316
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.63793815
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59612450
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59612450
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58494096
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58414551
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56888780
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54732702
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52693354
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50656133
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50656133
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50408395
44SOX2_20726797_ChIP-Seq_SW620_Human1.50029329
45ZNF263_19887448_ChIP-Seq_K562_Human1.47975435
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47723069
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46295835
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44895846
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44428627
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44121214
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.44021716
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41384436
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41254822
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38704818
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36917931
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36787805
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36619742
58PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.36483780
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.35601668
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33421602
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32483046
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31127619
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29767331
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.28652602
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28613266
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27626523
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26024277
68ATF3_27146783_Chip-Seq_COLON_Human1.25295994
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24719110
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22635749
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22388296
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20150391
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20082004
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19664235
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19411179
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19105243
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18728257
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18492948
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.16754506
80* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.16118274
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.14355895
82* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13508316
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13402255
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13227858
85AR_21572438_ChIP-Seq_LNCaP_Human1.12878746
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10775035
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10775035
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10739387
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10456324
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09766395
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.09735535
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09607201
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09391271
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09239666
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.08849913
96TP53_18474530_ChIP-ChIP_U2OS_Human1.07740933
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06717055
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.05930417
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02448069
100STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01883811
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00951516
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00602891
103KDM2B_26808549_Chip-Seq_K562_Human1.00282317
104CTCF_27219007_Chip-Seq_Bcells_Human0.99932192
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99924282
106GATA1_19941826_ChIP-Seq_K562_Human0.99249325
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98814093
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98453207
109GATA4_25053715_ChIP-Seq_YYC3_Human0.98286810
110BRD4_25478319_ChIP-Seq_HGPS_Human0.98230760
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97714099
112* SA1_22415368_ChIP-Seq_MEFs_Mouse0.97537050
113* SMC4_20622854_ChIP-Seq_HELA_Human0.97306920
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96312453
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95829500
116TP53_22127205_ChIP-Seq_IMR90_Human0.95810049
117BCAT_22108803_ChIP-Seq_LS180_Human0.95319730
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94540896
119GATA6_25053715_ChIP-Seq_YYC3_Human0.92917822
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92213370
121* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91363292
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91169857
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90820309
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90820309
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90820309
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90159667
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89663117
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88522562
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88215703
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88003486
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87186566
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.87034822
133RACK7_27058665_Chip-Seq_MCF-7_Human0.86660585
134CSB_26484114_Chip-Seq_FIBROBLAST_Human0.85096625
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83947445
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83628164
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.83094385
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.82811824
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82018213
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.81554608
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.80438591
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79822131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001879_abnormal_lymphatic_vessel4.62279150
2MP0005670_abnormal_white_adipose4.52542824
3MP0010368_abnormal_lymphatic_system4.48727468
4MP0008438_abnormal_cutaneous_collagen4.35642184
5MP0004272_abnormal_basement_membrane4.05938876
6MP0003724_increased_susceptibility_to3.50545665
7MP0000013_abnormal_adipose_tissue3.37064697
8MP0002139_abnormal_hepatobiliary_system3.25461559
9MP0005360_urolithiasis3.13810007
10MP0003279_aneurysm2.75055706
11MP0002837_dystrophic_cardiac_calcinosis2.71527819
12MP0005666_abnormal_adipose_tissue2.67007618
13MP0004130_abnormal_muscle_cell2.63456968
14MP0005275_abnormal_skin_tensile2.52968086
15MP0003868_abnormal_feces_composition2.41924809
16MP0006054_spinal_hemorrhage2.41500709
17MP0004185_abnormal_adipocyte_glucose2.37926098
18MP0004084_abnormal_cardiac_muscle2.37866196
19MP0004215_abnormal_myocardial_fiber2.37788311
20MP0005375_adipose_tissue_phenotype2.22581094
21MP0005167_abnormal_blood-brain_barrier2.19111485
22MP0005365_abnormal_bile_salt2.16060235
23MP0003828_pulmonary_edema2.07668404
24MP0000751_myopathy2.05431571
25MP0000003_abnormal_adipose_tissue2.00945728
26MP0009384_cardiac_valve_regurgitation1.95587172
27MP0010234_abnormal_vibrissa_follicle1.95414461
28MP0005503_abnormal_tendon_morphology1.94764354
29MP0001958_emphysema1.94370582
30MP0006138_congestive_heart_failure1.91467879
31MP0002295_abnormal_pulmonary_circulatio1.88869847
32MP0003705_abnormal_hypodermis_morpholog1.81856405
33MP0009780_abnormal_chondrocyte_physiolo1.79745415
34MP0005623_abnormal_meninges_morphology1.79465587
35MP0005085_abnormal_gallbladder_physiolo1.78379188
36MP0001661_extended_life_span1.71098203
37MP0008775_abnormal_heart_ventricle1.69976043
38MP0004484_altered_response_of1.69319228
39MP0000749_muscle_degeneration1.66983806
40MP0005330_cardiomyopathy1.66531008
41MP0000750_abnormal_muscle_regeneration1.64166050
42MP0004147_increased_porphyrin_level1.63272628
43MP0005620_abnormal_muscle_contractility1.62822119
44MP0000767_abnormal_smooth_muscle1.62677309
45MP0004036_abnormal_muscle_relaxation1.62562415
46MP0005164_abnormal_response_to1.58504042
47MP0003191_abnormal_cellular_cholesterol1.56799697
48MP0005595_abnormal_vascular_smooth1.56026276
49MP0003950_abnormal_plasma_membrane1.54866234
50MP0002972_abnormal_cardiac_muscle1.54548486
51MP0005165_increased_susceptibility_to1.50192973
52MP0001544_abnormal_cardiovascular_syste1.48088275
53MP0005385_cardiovascular_system_phenoty1.48088275
54MP0003959_abnormal_lean_body1.42656751
55MP0003566_abnormal_cell_adhesion1.39975584
56MP0000343_altered_response_to1.37644719
57MP0002009_preneoplasia1.37043300
58MP0005257_abnormal_intraocular_pressure1.36943585
59MP0010030_abnormal_orbit_morphology1.31862301
60MP0002108_abnormal_muscle_morphology1.29960261
61MP0000249_abnormal_blood_vessel1.29717874
62MP0002970_abnormal_white_adipose1.26228511
63MP0004087_abnormal_muscle_fiber1.26147996
64MP0005409_darkened_coat_color1.24475445
65MP0004883_abnormal_blood_vessel1.22319483
66MP0010630_abnormal_cardiac_muscle1.22085684
67MP0001849_ear_inflammation1.20270385
68MP0010352_gastrointestinal_tract_polyps1.17449025
69MP0002796_impaired_skin_barrier1.15448175
70MP0002128_abnormal_blood_circulation1.14711784
71MP0000230_abnormal_systemic_arterial1.13059754
72MP0005084_abnormal_gallbladder_morpholo1.12121682
73MP0002127_abnormal_cardiovascular_syste1.10246743
74MP0009379_abnormal_foot_pigmentation1.08669859
75MP0002166_altered_tumor_susceptibility1.08627414
76MP0003091_abnormal_cell_migration1.05382345
77MP0004085_abnormal_heartbeat1.04964133
78MP0002896_abnormal_bone_mineralization1.03755553
79MP0002332_abnormal_exercise_endurance1.02409454
80MP0001614_abnormal_blood_vessel1.02366349
81MP0000762_abnormal_tongue_morphology1.00996380
82MP0009115_abnormal_fat_cell1.00853634
83MP0004019_abnormal_vitamin_homeostasis1.00173676
84MP0000467_abnormal_esophagus_morphology0.98491666
85MP0001542_abnormal_bone_strength0.97238031
86MP0009840_abnormal_foam_cell0.97206063
87MP0009643_abnormal_urine_homeostasis0.95899794
88MP0002971_abnormal_brown_adipose0.95426462
89MP0010329_abnormal_lipoprotein_level0.95228378
90MP0005501_abnormal_skin_physiology0.92440442
91MP0000858_altered_metastatic_potential0.91544355
92MP0002138_abnormal_hepatobiliary_system0.90363886
93MP0001666_abnormal_nutrient_absorption0.90211034
94MP0002925_abnormal_cardiovascular_devel0.89691254
95MP0003879_abnormal_hair_cell0.89615631
96MP0005332_abnormal_amino_acid0.89391328
97MP0003806_abnormal_nucleotide_metabolis0.88905050
98MP0003045_fibrosis0.87238279
99MP0002133_abnormal_respiratory_system0.85722601
100MP0005388_respiratory_system_phenotype0.85722601
101MP0005508_abnormal_skeleton_morphology0.83649127
102MP0002877_abnormal_melanocyte_morpholog0.83401778
103MP0000759_abnormal_skeletal_muscle0.83044923
104MP0000163_abnormal_cartilage_morphology0.82577541
105MP0003646_muscle_fatigue0.81980920
106MP0005451_abnormal_body_composition0.81393929
107MP0003137_abnormal_impulse_conducting0.81212273
108MP0003453_abnormal_keratinocyte_physiol0.81204504
109MP0004858_abnormal_nervous_system0.80172508
110MP0000609_abnormal_liver_physiology0.80165201
111MP0005369_muscle_phenotype0.79975304
112MP0002060_abnormal_skin_morphology0.79356698
113MP0005584_abnormal_enzyme/coenzyme_acti0.79032403
114MP0005058_abnormal_lysosome_morphology0.78683044
115MP0009053_abnormal_anal_canal0.76838363
116MP0001243_abnormal_dermal_layer0.76549765
117MP0005535_abnormal_body_temperature0.76376518
118MP0001764_abnormal_homeostasis0.75519107
119MP0002933_joint_inflammation0.75307550
120MP0001664_abnormal_digestion0.73326118
121MP0000733_abnormal_muscle_development0.73039587
122MP0003300_gastrointestinal_ulcer0.72391205
123MP0001881_abnormal_mammary_gland0.70825431
124MP0009278_abnormal_bone_marrow0.69579093
125MP0000678_abnormal_parathyroid_gland0.68870357
126MP0000266_abnormal_heart_morphology0.68619673
127MP0003011_delayed_dark_adaptation0.68241507
128MP0001663_abnormal_digestive_system0.67742368
129MP0001533_abnormal_skeleton_physiology0.67620565
130MP0005023_abnormal_wound_healing0.66422697
131MP0002106_abnormal_muscle_physiology0.66330424
132MP0003690_abnormal_glial_cell0.65153955
133MP0001851_eye_inflammation0.64648557
134MP0008004_abnormal_stomach_pH0.61422810
135MP0005334_abnormal_fat_pad0.61411515
136MP0005083_abnormal_biliary_tract0.60574497
137MP0003186_abnormal_redox_activity0.58785697
138MP0000747_muscle_weakness0.58333150
139MP0003385_abnormal_body_wall0.57677386
140MP0002118_abnormal_lipid_homeostasis0.57084570
141MP0002006_tumorigenesis0.56777494
142MP0003448_altered_tumor_morphology0.56579360
143MP0002269_muscular_atrophy0.52216514
144MP0008961_abnormal_basal_metabolism0.51978300
145MP0002876_abnormal_thyroid_physiology0.51815527
146MP0001784_abnormal_fluid_regulation0.51673929

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.83457732
2Aortic aneurysm (HP:0004942)4.66044276
3Protrusio acetabuli (HP:0003179)4.52429703
4Broad metatarsal (HP:0001783)4.43305460
5Muscle fiber splitting (HP:0003555)4.32129739
6Increased connective tissue (HP:0009025)4.18176685
7Short hallux (HP:0010109)4.09956883
8Nonimmune hydrops fetalis (HP:0001790)4.02227634
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.97832531
10Aortic dissection (HP:0002647)3.93068864
11Aplasia/Hypoplasia of the hallux (HP:0008362)3.79722181
12Spinal rigidity (HP:0003306)3.72989125
13Cerebral aneurysm (HP:0004944)3.70798429
14Acanthosis nigricans (HP:0000956)3.55539302
15Polycythemia (HP:0001901)3.49186989
16Vertebral compression fractures (HP:0002953)3.48161918
17Ventricular tachycardia (HP:0004756)3.45929858
18Pulmonary artery stenosis (HP:0004415)3.43680090
19Right ventricular cardiomyopathy (HP:0011663)3.43119491
20Difficulty running (HP:0009046)3.42589125
21Vascular tortuosity (HP:0004948)3.36881743
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.33322133
23Congenital, generalized hypertrichosis (HP:0004540)3.31089424
24Hyporeflexia of lower limbs (HP:0002600)3.27227537
25Lipoatrophy (HP:0100578)3.26504035
26Increased variability in muscle fiber diameter (HP:0003557)3.23372730
27Exercise-induced muscle cramps (HP:0003710)3.21402249
28Venous abnormality (HP:0002624)3.16614662
29Type 1 muscle fiber predominance (HP:0003803)3.15224355
30Ankle contracture (HP:0006466)3.07444841
31Atrial fibrillation (HP:0005110)3.07324795
32Oligomenorrhea (HP:0000876)3.07047063
33Venous insufficiency (HP:0005293)3.05984330
34Sudden death (HP:0001699)3.04024145
35Hyperactive renin-angiotensin system (HP:0000841)3.02562013
36Bone cyst (HP:0012062)2.95629712
37Hemorrhage of the eye (HP:0011885)2.89476551
38Abnormality of skeletal muscle fiber size (HP:0012084)2.89265650
39Primary atrial arrhythmia (HP:0001692)2.82640871
40Cervical subluxation (HP:0003308)2.82170702
41Supraventricular arrhythmia (HP:0005115)2.79679025
42Hypoglycemic coma (HP:0001325)2.74817482
43Lymphangioma (HP:0100764)2.74488097
44Hypertriglyceridemia (HP:0002155)2.70293825
45Mesangial abnormality (HP:0001966)2.68658665
46Chondrocalcinosis (HP:0000934)2.68373342
47Muscle stiffness (HP:0003552)2.66359746
48Neonatal short-limb short stature (HP:0008921)2.64753799
49Supraventricular tachycardia (HP:0004755)2.63871569
50Prominent supraorbital ridges (HP:0000336)2.62909827
51Flat acetabular roof (HP:0003180)2.58327282
52Aneurysm (HP:0002617)2.57900377
53Round ear (HP:0100830)2.56813588
54Abnormality of Sharpey fibers (HP:0100685)2.55894797
55Abnormality of complement system (HP:0005339)2.55151963
56Insulin-resistant diabetes mellitus (HP:0000831)2.50990660
57Abnormality of carpal bone ossification (HP:0006257)2.43743895
58Thin bony cortex (HP:0002753)2.43375351
59Dilatation of the ascending aorta (HP:0005111)2.41186679
60Absent toe (HP:0010760)2.41007830
61Spinal cord compression (HP:0002176)2.40929071
62Facial diplegia (HP:0001349)2.38324596
63Complement deficiency (HP:0004431)2.38096217
64Shallow orbits (HP:0000586)2.37982586
65Reduced subcutaneous adipose tissue (HP:0003758)2.37875916
66Soft skin (HP:0000977)2.37302954
67Hyperparathyroidism (HP:0000843)2.37134356
68Dilated cardiomyopathy (HP:0001644)2.37103585
69Hypoplasia of the iris (HP:0007676)2.37019933
70Systemic lupus erythematosus (HP:0002725)2.35399493
71Hypoalphalipoproteinemia (HP:0003233)2.32864253
72Myotonia (HP:0002486)2.31646240
73Bladder diverticulum (HP:0000015)2.30950700
74EMG: myopathic abnormalities (HP:0003458)2.30286914
75Decreased circulating renin level (HP:0003351)2.29050187
76Alkalosis (HP:0001948)2.28575680
77Hematochezia (HP:0002573)2.28460511
78Axonal loss (HP:0003447)2.27480554
79Arterial tortuosity (HP:0005116)2.23500763
80Abnormality of the anterior chamber (HP:0000593)2.21914746
81Myoglobinuria (HP:0002913)2.20365292
82Osteolytic defects of the hand bones (HP:0009699)2.19815900
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.19815900
84Wrist flexion contracture (HP:0001239)2.18716990
85Abnormality of the calf musculature (HP:0001430)2.18030448
86Pigmentary retinal degeneration (HP:0001146)2.16309386
87Growth hormone excess (HP:0000845)2.15131943
88Metabolic alkalosis (HP:0200114)2.14710209
89Muscular dystrophy (HP:0003560)2.14223360
90Abnormal delivery (HP:0001787)2.14118122
91Distal lower limb muscle weakness (HP:0009053)2.13973506
92Elbow flexion contracture (HP:0002987)2.13657497
93Xanthomatosis (HP:0000991)2.12105453
94Abnormality of the acetabulum (HP:0003170)2.11716613
95Flat capital femoral epiphysis (HP:0003370)2.11443470
96Distal lower limb amyotrophy (HP:0008944)2.11250322
97Back pain (HP:0003418)2.10701049
98Abnormality of proline metabolism (HP:0010907)2.10530374
99Hydroxyprolinuria (HP:0003080)2.10530374
100Deep venous thrombosis (HP:0002625)2.10186789
101Mitral stenosis (HP:0001718)2.10182524
102Cardiovascular calcification (HP:0011915)2.09908552
103Atrophic scars (HP:0001075)2.08007098
104Coronal craniosynostosis (HP:0004440)2.07862400
105Breech presentation (HP:0001623)2.07527077
106Scapular winging (HP:0003691)2.07493598
107Coxa vara (HP:0002812)2.07338937
108Calf muscle hypertrophy (HP:0008981)2.06754904
109Abnormal hemoglobin (HP:0011902)2.06179325
110Wormian bones (HP:0002645)2.06112533
111Ovoid vertebral bodies (HP:0003300)2.04775089
112Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04106548
113Intrahepatic cholestasis (HP:0001406)2.02776060
114Difficulty climbing stairs (HP:0003551)2.02417280
115Abnormality of renin-angiotensin system (HP:0000847)2.01870730
116Abnormality of dentin (HP:0010299)2.01713565
117Esophageal varix (HP:0002040)2.01241619
118Joint stiffness (HP:0001387)2.00839420
119Neck muscle weakness (HP:0000467)1.99858250
120Short nail (HP:0001799)1.99492597
121Hypoplastic ischia (HP:0003175)1.98264749
122Achilles tendon contracture (HP:0001771)1.97561326
123Insulin resistance (HP:0000855)1.97308943
124Spontaneous hematomas (HP:0007420)1.97242608
125Exercise-induced myalgia (HP:0003738)1.96641068
126Cerebral hemorrhage (HP:0001342)1.95353893
127Toxemia of pregnancy (HP:0100603)1.95169262
128Blue sclerae (HP:0000592)1.94910707
129Absent hand (HP:0004050)1.94443037
130Abnormal ossification of hand bones (HP:0005921)1.94342119
131Ectopia lentis (HP:0001083)1.94160204
132Ileus (HP:0002595)1.94031197
133Prolonged QT interval (HP:0001657)1.93795317
134Abnormality of the Achilles tendon (HP:0005109)1.91696320
135Follicular hyperkeratosis (HP:0007502)1.91361955
136Hyperlipoproteinemia (HP:0010980)1.90687287
137Adactyly (HP:0009776)1.90571734
138Fragile skin (HP:0001030)1.90325525
139Fat malabsorption (HP:0002630)1.89803516
140Mildly elevated creatine phosphokinase (HP:0008180)1.89526813
141Rhabdomyolysis (HP:0003201)1.89435465
142Decreased subcutaneous fat (HP:0001002)1.89254384
143Abdominal distention (HP:0003270)1.86968989
144Muscle hypertrophy of the lower extremities (HP:0008968)1.86647022
145Abnormal cartilage morphology (HP:0002763)1.85251342
146Myocardial infarction (HP:0001658)1.85012269
147Bradycardia (HP:0001662)1.84383950
148Malnutrition (HP:0004395)1.83256288
149Palpitations (HP:0001962)1.83159784
150Abnormality of the ischium (HP:0003174)1.82346029
151Abnormality of fatty-acid metabolism (HP:0004359)1.82241365
152Generalized amyotrophy (HP:0003700)1.81943950
153Flattened epiphyses (HP:0003071)1.79501263
154Premature skin wrinkling (HP:0100678)1.77842269
155Upper limb amyotrophy (HP:0009129)1.77542855
156Distal upper limb amyotrophy (HP:0007149)1.77542855
157Cupped ribs (HP:0000887)1.76621685
158Mitral regurgitation (HP:0001653)1.74233087
159Vascular calcification (HP:0004934)1.72798956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.93786152
2KDR5.37580326
3MYLK4.08829250
4EPHB22.96712577
5CAMK1D2.59846922
6TTN2.52677682
7TGFBR22.34407244
8PDGFRA2.33099111
9TRIB32.20458085
10CAMK1G1.84301564
11PTK2B1.82824452
12GRK11.82489463
13MAP3K121.72880611
14ERN11.65886884
15IRAK31.53456525
16FRK1.50561167
17RIPK11.48102145
18PAK21.45776708
19PIK3CA1.43711952
20SIK11.41262901
21EPHA31.40530169
22DMPK1.34782771
23PDK21.33347264
24MAP2K31.31731117
25BCKDK1.30589963
26TRPM71.24082711
27PHKG21.22180162
28PHKG11.22180162
29FER1.21325295
30NTRK11.19208861
31MAPKAPK31.18660470
32ARAF1.18257173
33NUAK11.12073120
34TGFBR11.05752331
35LMTK21.05554104
36PAK31.02009123
37MET1.00256973
38MAP2K11.00097352
39MAPK120.98244469
40STK380.96681096
41PRKAA20.96527225
42INSRR0.94993360
43DAPK30.94613853
44ICK0.94193954
45ILK0.93231764
46PRPF4B0.89743184
47PRKD10.89446368
48NME20.88642968
49KIT0.88034764
50PRKG20.87561720
51GRK50.87536708
52PDGFRB0.87317682
53PDPK10.87297926
54ROCK10.83887175
55MOS0.83184581
56LIMK10.82677197
57DDR20.79392642
58EPHB10.77925651
59PDK40.77688947
60PDK30.77688947
61STK390.77440259
62LATS20.77114806
63BMX0.76647726
64OBSCN0.76537682
65PRKD30.76348646
66AKT30.75001922
67CDK90.71388301
68DAPK20.70995547
69LATS10.70387687
70PIK3CG0.69423268
71NEK90.68723036
72PTK60.64474498
73PAK40.63853042
74MAP3K30.60947810
75CAMK2D0.60852900
76INSR0.60550290
77BCR0.59461265
78MAPK110.59260481
79PIM20.58906939
80MAPK70.58854241
81CAMK2G0.58263739
82WNK40.58033339
83PKN20.57939289
84PTK20.57032970
85JAK10.56916208
86STK240.54914276
87CDC42BPA0.53847719
88ABL20.53429236
89ZAK0.52840762
90MAP3K20.52175894
91ACVR1B0.52171178
92TEC0.52044690
93SCYL20.51420295
94IGF1R0.51262443
95CDK80.50975032
96PRKCE0.50265323
97TESK10.50039240
98EEF2K0.49830848
99SMG10.49167371
100MAP2K20.48494513
101RET0.47709185
102MAPK40.47511910
103FGFR20.46004807
104MAP3K110.45901229
105RPS6KA20.45454969
106TESK20.44533424
107CAMK10.44281075
108FLT30.44255158
109MAP3K10.41827211
110KSR20.41176245
111MAPK150.40565407
112BRAF0.39192053
113ZAP700.39189947
114CAMK40.38573244
115PRKD20.37743039
116SRC0.37544178
117LRRK20.37259563
118NEK10.37162538
119CAMK2B0.36893028
120PAK10.35825742
121FGFR40.34842375
122MAP3K60.34444179
123TBK10.34185316
124MTOR0.33921309
125GSK3A0.33372501
126PRKACG0.32542920
127ROCK20.32512257
128MST1R0.32079398
129PINK10.30887215
130ERBB30.30838619
131PRKCH0.30281368
132CAMKK20.30065005
133MAP3K80.29453462
134EPHA20.29416963
135ADRBK10.29416144
136MAPKAPK20.29193042
137MAPKAPK50.28861369
138EGFR0.28494472
139JAK30.27679738
140AKT20.27220088
141CSK0.26906572
142MUSK0.26361130
143ERBB40.25760714

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.52460195
2PPAR signaling pathway_Homo sapiens_hsa033203.22982108
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.88317496
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.78476160
5ECM-receptor interaction_Homo sapiens_hsa045122.73038640
6Propanoate metabolism_Homo sapiens_hsa006402.71699717
7Dilated cardiomyopathy_Homo sapiens_hsa054142.64599586
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58160136
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55761384
10Focal adhesion_Homo sapiens_hsa045102.54686744
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.47366590
12Fatty acid degradation_Homo sapiens_hsa000712.15147213
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09070701
14Histidine metabolism_Homo sapiens_hsa003402.08403049
15Sulfur relay system_Homo sapiens_hsa041222.07323103
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05484857
17Fatty acid metabolism_Homo sapiens_hsa012122.03800616
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03063137
19Fatty acid biosynthesis_Homo sapiens_hsa000611.90305100
20Retinol metabolism_Homo sapiens_hsa008301.89908143
21Malaria_Homo sapiens_hsa051441.66587137
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.64982459
23Chemical carcinogenesis_Homo sapiens_hsa052041.63365884
24Cardiac muscle contraction_Homo sapiens_hsa042601.60736693
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.57912869
26Adherens junction_Homo sapiens_hsa045201.57352614
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54656372
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.53539578
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53508284
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.49966117
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47256317
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41068852
33Starch and sucrose metabolism_Homo sapiens_hsa005001.39079384
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.37981946
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.36363434
36Fructose and mannose metabolism_Homo sapiens_hsa000511.32361329
37Renin-angiotensin system_Homo sapiens_hsa046141.31901597
38Tryptophan metabolism_Homo sapiens_hsa003801.28326960
39Galactose metabolism_Homo sapiens_hsa000521.27264186
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26085298
41Mineral absorption_Homo sapiens_hsa049781.25551823
42Proteoglycans in cancer_Homo sapiens_hsa052051.23459414
43Rap1 signaling pathway_Homo sapiens_hsa040151.21779302
44Amoebiasis_Homo sapiens_hsa051461.18551310
45Tight junction_Homo sapiens_hsa045301.17233625
46HIF-1 signaling pathway_Homo sapiens_hsa040661.14927534
47Viral myocarditis_Homo sapiens_hsa054161.14169038
48Arginine and proline metabolism_Homo sapiens_hsa003301.13941602
49Notch signaling pathway_Homo sapiens_hsa043301.11683157
50Renin secretion_Homo sapiens_hsa049241.08854151
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06940585
52Parkinsons disease_Homo sapiens_hsa050121.05612942
53Oxidative phosphorylation_Homo sapiens_hsa001901.05390208
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.04055640
55Biosynthesis of amino acids_Homo sapiens_hsa012301.02297662
56Fatty acid elongation_Homo sapiens_hsa000621.02079066
57AMPK signaling pathway_Homo sapiens_hsa041521.01413933
58Insulin resistance_Homo sapiens_hsa049310.99458869
59Alzheimers disease_Homo sapiens_hsa050100.98904352
60Protein digestion and absorption_Homo sapiens_hsa049740.97964750
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97447283
62TGF-beta signaling pathway_Homo sapiens_hsa043500.97030188
63Platelet activation_Homo sapiens_hsa046110.96222206
64Ras signaling pathway_Homo sapiens_hsa040140.94027571
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93119518
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92462286
67Small cell lung cancer_Homo sapiens_hsa052220.90878376
68Bile secretion_Homo sapiens_hsa049760.90034314
69Glycerolipid metabolism_Homo sapiens_hsa005610.89313880
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87283599
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87010092
72Other glycan degradation_Homo sapiens_hsa005110.86686856
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84176009
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81399760
75Pathways in cancer_Homo sapiens_hsa052000.81352270
76Dorso-ventral axis formation_Homo sapiens_hsa043200.80869523
77Complement and coagulation cascades_Homo sapiens_hsa046100.79184514
78Renal cell carcinoma_Homo sapiens_hsa052110.79141797
79Pentose phosphate pathway_Homo sapiens_hsa000300.77902965
80Pyruvate metabolism_Homo sapiens_hsa006200.77661389
81Ovarian steroidogenesis_Homo sapiens_hsa049130.76548847
82beta-Alanine metabolism_Homo sapiens_hsa004100.76497903
83Vitamin B6 metabolism_Homo sapiens_hsa007500.76403689
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74722248
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74505009
86Carbon metabolism_Homo sapiens_hsa012000.74394560
87Phenylalanine metabolism_Homo sapiens_hsa003600.74270823
88Fat digestion and absorption_Homo sapiens_hsa049750.70348658
89cAMP signaling pathway_Homo sapiens_hsa040240.69099406
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68089866
91Caffeine metabolism_Homo sapiens_hsa002320.67957779
92Folate biosynthesis_Homo sapiens_hsa007900.64863265
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62960675
94Hippo signaling pathway_Homo sapiens_hsa043900.62790034
95Vitamin digestion and absorption_Homo sapiens_hsa049770.62424151
96Huntingtons disease_Homo sapiens_hsa050160.62320383
97Toxoplasmosis_Homo sapiens_hsa051450.60357829
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59842878
99Gap junction_Homo sapiens_hsa045400.58973218
100Oxytocin signaling pathway_Homo sapiens_hsa049210.57833959
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57541600
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55643061
103Melanoma_Homo sapiens_hsa052180.55213292
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55027127
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54979857
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.54794314
107Peroxisome_Homo sapiens_hsa041460.54391056
108African trypanosomiasis_Homo sapiens_hsa051430.54254973
109Nitrogen metabolism_Homo sapiens_hsa009100.52102253
110Butanoate metabolism_Homo sapiens_hsa006500.51798468
111Arachidonic acid metabolism_Homo sapiens_hsa005900.49884567
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48896615
113Insulin signaling pathway_Homo sapiens_hsa049100.48555467
114ABC transporters_Homo sapiens_hsa020100.48435757
115Axon guidance_Homo sapiens_hsa043600.47511866
116Tyrosine metabolism_Homo sapiens_hsa003500.46450425
117Rheumatoid arthritis_Homo sapiens_hsa053230.46398845
118Melanogenesis_Homo sapiens_hsa049160.46361434
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46256699
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46069110
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45748773
122Endocytosis_Homo sapiens_hsa041440.45216397
123Prion diseases_Homo sapiens_hsa050200.44967043
124Arginine biosynthesis_Homo sapiens_hsa002200.43943651
125Thyroid hormone synthesis_Homo sapiens_hsa049180.43757093
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43173945
127Glucagon signaling pathway_Homo sapiens_hsa049220.42704388
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42482827
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42446591
130Salivary secretion_Homo sapiens_hsa049700.41155668
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40555731
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40392179
133Glutathione metabolism_Homo sapiens_hsa004800.39113713
134VEGF signaling pathway_Homo sapiens_hsa043700.39058777
135Pancreatic secretion_Homo sapiens_hsa049720.38322047
136Thyroid cancer_Homo sapiens_hsa052160.33397920
137Vibrio cholerae infection_Homo sapiens_hsa051100.32669294
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31557189
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28975988
140Lysine degradation_Homo sapiens_hsa003100.28409587
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27867163
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25163227
143Metabolic pathways_Homo sapiens_hsa011000.24728727

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