HPSE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.88221900
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.88221900
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.88221900
4modulation by symbiont of host immune response (GO:0052553)6.88221900
5positive regulation by symbiont of host defense response (GO:0052509)6.88221900
6modulation by symbiont of host defense response (GO:0052031)6.88221900
7regulation of interferon-beta biosynthetic process (GO:0045357)6.79901508
8macrophage activation involved in immune response (GO:0002281)5.46014110
9positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.05062922
10positive regulation of interferon-alpha production (GO:0032727)4.95422991
11regulation of B cell receptor signaling pathway (GO:0050855)4.81914110
12neutrophil activation involved in immune response (GO:0002283)4.77133840
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.73509730
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73509730
15regulation of interferon-alpha production (GO:0032647)4.69204983
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60975082
17antigen processing and presentation of endogenous antigen (GO:0019883)4.56730722
18immunoglobulin mediated immune response (GO:0016064)4.52143465
19negative regulation of interleukin-12 production (GO:0032695)4.48807878
20response to host immune response (GO:0052572)4.34445956
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.34445956
22interferon-gamma production (GO:0032609)3.98940464
23detection of other organism (GO:0098543)3.98640225
24protein K11-linked deubiquitination (GO:0035871)3.96947311
25response to host (GO:0075136)3.96929816
26response to host defenses (GO:0052200)3.96929816
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.96929816
28respiratory burst (GO:0045730)3.96391304
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.85561590
30pinocytosis (GO:0006907)3.84539987
31mannose metabolic process (GO:0006013)3.81672194
32myeloid cell activation involved in immune response (GO:0002275)3.65195389
33activated T cell proliferation (GO:0050798)3.64997005
34detection of bacterium (GO:0016045)3.64845842
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62229835
36positive regulation of antigen processing and presentation (GO:0002579)3.61136075
37neutrophil mediated immunity (GO:0002446)3.57893912
38macrophage activation (GO:0042116)3.53525594
39positive regulation of gamma-delta T cell activation (GO:0046645)3.51584713
40regulation of interleukin-8 biosynthetic process (GO:0045414)3.51161576
41detection of molecule of bacterial origin (GO:0032490)3.49384131
42positive regulation of interferon-beta production (GO:0032728)3.48644621
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47495703
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.44421493
45detection of external biotic stimulus (GO:0098581)3.41508217
46positive regulation of B cell differentiation (GO:0045579)3.40045765
47regulation of gamma-delta T cell activation (GO:0046643)3.39258210
48microglial cell activation (GO:0001774)3.39204797
49neutrophil activation (GO:0042119)3.37812297
50negative regulation of phagocytosis (GO:0050765)3.35625840
51negative regulation of interleukin-8 production (GO:0032717)3.35551982
52response to peptidoglycan (GO:0032494)3.32391228
53negative regulation of T cell mediated immunity (GO:0002710)3.31915268
54granulocyte activation (GO:0036230)3.26960133
55leukocyte degranulation (GO:0043299)3.26208035
56B cell receptor signaling pathway (GO:0050853)3.25465169
57positive regulation of mast cell activation (GO:0033005)3.25181374
58B cell mediated immunity (GO:0019724)3.24787500
59superoxide anion generation (GO:0042554)3.23611438
60natural killer cell mediated immunity (GO:0002228)3.20033622
61natural killer cell mediated cytotoxicity (GO:0042267)3.20033622
62I-kappaB phosphorylation (GO:0007252)3.18033551
63melanin biosynthetic process (GO:0042438)3.17641631
64cellular extravasation (GO:0045123)3.14078331
65regulation of regulatory T cell differentiation (GO:0045589)3.13656509
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.11637194
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10447323
68leukocyte aggregation (GO:0070486)3.10429614
69detection of biotic stimulus (GO:0009595)3.07482473
70regulation of antigen processing and presentation (GO:0002577)3.03489755
71tolerance induction (GO:0002507)3.00709069
72regulation of mast cell degranulation (GO:0043304)3.00059959
73negative regulation of mast cell activation (GO:0033004)2.99205871
74melanin metabolic process (GO:0006582)2.96011241
75response to muramyl dipeptide (GO:0032495)2.95322911
76regulation of mast cell activation (GO:0033003)2.93223213
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93039452
78negative regulation of interleukin-1 production (GO:0032692)2.92549945
79positive regulation of mast cell degranulation (GO:0043306)2.92235403
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.92235403
81regulation of T cell mediated cytotoxicity (GO:0001914)2.90207289
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.89788385
83regulation of B cell differentiation (GO:0045577)2.87271118
84antigen processing and presentation via MHC class Ib (GO:0002475)2.87229180
85apoptotic cell clearance (GO:0043277)2.86983742
86regulation of T cell tolerance induction (GO:0002664)2.86975679
87negative regulation of interleukin-1 beta production (GO:0032691)2.86273529
88natural killer cell activation involved in immune response (GO:0002323)2.85998732
89keratan sulfate catabolic process (GO:0042340)2.85627255
90regulation of tolerance induction (GO:0002643)2.84824926
91regulation of leukocyte degranulation (GO:0043300)2.84598172
92dendritic cell migration (GO:0036336)2.82685265
93leukocyte migration involved in inflammatory response (GO:0002523)2.82611174
94negative regulation of granulocyte differentiation (GO:0030853)2.81183204
95interferon-gamma-mediated signaling pathway (GO:0060333)2.80448165
96actin nucleation (GO:0045010)2.80257090
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.79530128
98positive regulation of interleukin-1 beta secretion (GO:0050718)2.79500283
99response to type I interferon (GO:0034340)2.79073709
100regulation of mast cell activation involved in immune response (GO:0033006)2.78907837
101negative regulation of leukocyte mediated immunity (GO:0002704)2.78426965
102type I interferon signaling pathway (GO:0060337)2.77770814
103cellular response to type I interferon (GO:0071357)2.77770814
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77709610
105negative regulation of T-helper cell differentiation (GO:0045623)2.77709610
106regulation of phagocytosis (GO:0050764)2.74655453
107negative regulation of interleukin-17 production (GO:0032700)2.73271341
108negative regulation of B cell proliferation (GO:0030889)2.73233913
109positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72863598
110regulation of memory T cell differentiation (GO:0043380)2.72747116
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72231317
112response to fungus (GO:0009620)2.72040019
113leukocyte mediated cytotoxicity (GO:0001909)2.71893783
114positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71843439
115myeloid leukocyte activation (GO:0002274)2.71660983
116negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70727679
117negative regulation of cell killing (GO:0031342)2.70727679
118defense response to protozoan (GO:0042832)2.69291163
119regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.68836967
120response to protozoan (GO:0001562)2.68458196
121negative regulation of interleukin-6 production (GO:0032715)2.68021663
122mast cell activation (GO:0045576)2.66988342
123response to interleukin-15 (GO:0070672)2.66846015
124regulation of interferon-beta production (GO:0032648)2.66728349
125regulation of mononuclear cell migration (GO:0071675)2.66612118
126myeloid leukocyte mediated immunity (GO:0002444)2.66608723
127regulation of gamma-delta T cell differentiation (GO:0045586)2.66121136
128germinal center formation (GO:0002467)2.65960310
129neutrophil chemotaxis (GO:0030593)2.65192262
130positive regulation of leukocyte degranulation (GO:0043302)2.64086518
131regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63882197
132reactive oxygen species biosynthetic process (GO:1903409)2.62977565
133myeloid dendritic cell activation (GO:0001773)2.60282305
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60060431
135regulation of cholesterol storage (GO:0010885)2.58179435
136hydrogen peroxide biosynthetic process (GO:0050665)2.57009540
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56847557
138regulation of interferon-gamma biosynthetic process (GO:0045072)2.56519275
139regulation of apoptotic cell clearance (GO:2000425)2.55442040
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54873601
141cytidine deamination (GO:0009972)2.54847711
142cytidine metabolic process (GO:0046087)2.54847711
143cytidine catabolic process (GO:0006216)2.54847711
144cellular response to thyroid hormone stimulus (GO:0097067)2.54750207
145production of molecular mediator involved in inflammatory response (GO:0002532)2.54420823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.89191858
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.46029432
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.12837905
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.92548040
5NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63858837
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39319556
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.38915260
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.25162576
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.24244887
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11341299
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.02242353
12SMAD_19615063_ChIP-ChIP_OVARY_Human3.01232864
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87078809
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83134925
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76914792
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.73589682
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.60234260
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59838704
19E2F7_22180533_ChIP-Seq_HELA_Human2.50846751
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50330270
21VDR_21846776_ChIP-Seq_THP-1_Human2.40671937
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22994200
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.21768302
24* SPI1_23547873_ChIP-Seq_NB4_Human2.20379189
25VDR_24763502_ChIP-Seq_THP-1_Human2.05492225
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00555129
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00421471
28SPI1_23127762_ChIP-Seq_K562_Human2.00326846
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98469886
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.94171556
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90550757
32MYC_22102868_ChIP-Seq_BL_Human1.88555896
33MAF_26560356_Chip-Seq_TH1_Human1.87623175
34MYB_26560356_Chip-Seq_TH2_Human1.86946715
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83044925
36PU_27001747_Chip-Seq_BMDM_Mouse1.80724961
37GBX2_23144817_ChIP-Seq_PC3_Human1.77633766
38SCL_19346495_ChIP-Seq_HPC-7_Human1.74657537
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72123325
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69215858
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68088552
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66847367
43MYB_26560356_Chip-Seq_TH1_Human1.65418691
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62127493
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59913721
46TFEB_21752829_ChIP-Seq_HELA_Human1.56827399
47RUNX_20019798_ChIP-Seq_JUKART_Human1.56714603
48TCF7_22412390_ChIP-Seq_EML_Mouse1.50828553
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47788829
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44609045
51* UTX_26944678_Chip-Seq_JUKART_Human1.43149506
52GATA1_22025678_ChIP-Seq_K562_Human1.40795577
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.40650725
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38735415
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.36179573
56* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35215015
57VDR_24787735_ChIP-Seq_THP-1_Human1.34995182
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32171524
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28921944
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28908104
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28488167
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25582091
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25102719
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23297239
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23265707
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23148913
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22241328
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22011707
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21452966
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.21408181
71* GATA3_27048872_Chip-Seq_THYMUS_Human1.20186175
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20153303
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19984347
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19849159
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.18739621
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18011908
77ER_23166858_ChIP-Seq_MCF-7_Human1.17155975
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16244182
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15417483
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15022350
81SMRT_27268052_Chip-Seq_Bcells_Human1.15018450
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12945262
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.12167237
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11576312
85GATA3_26560356_Chip-Seq_TH2_Human1.09288809
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09268583
87KDM2B_26808549_Chip-Seq_DND41_Human1.09202076
88VDR_22108803_ChIP-Seq_LS180_Human1.08927573
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08812472
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07984729
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05619760
92MAF_26560356_Chip-Seq_TH2_Human1.05037667
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.04658364
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04629116
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04384322
96* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04372895
97TAF15_26573619_Chip-Seq_HEK293_Human1.03001464
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01161225
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00403969
100TP53_16413492_ChIP-PET_HCT116_Human1.00237418
101STAT1_20625510_ChIP-Seq_HELA_Human0.99591138
102CLOCK_20551151_ChIP-Seq_293T_Human0.98122471
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.97958126
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.97836995
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97469396
106FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95447995
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94719293
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94484304
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93028907
110BCAT_22108803_ChIP-Seq_LS180_Human0.92210452
111LXR_22292898_ChIP-Seq_THP-1_Human0.90272163
112TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89877029
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89768486
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.89713948
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89346751
116IGF1R_20145208_ChIP-Seq_DFB_Human0.89233365
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89135976
118* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88275325
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.88135027
120* GATA3_21878914_ChIP-Seq_MCF-7_Human0.87254104
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87199347
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87185185
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87169926
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.86117054
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85699431
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.84477339
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84258313
128EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83744045
129KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83654811
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83395558
131GATA3_26560356_Chip-Seq_TH1_Human0.82260343
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82056002
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81984501
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81842793
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81649021
136OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80974304
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80799695
138* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80436538
139AR_25329375_ChIP-Seq_VCAP_Human0.80339669
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.79929466
141GATA1_19941826_ChIP-Seq_K562_Human0.78988171
142GATA2_19941826_ChIP-Seq_K562_Human0.78783619
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78617264
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78528753
145EGR1_19032775_ChIP-ChIP_M12_Human0.78522359
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77489450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.47584903
2MP0001835_abnormal_antigen_presentation3.83549643
3MP0003303_peritoneal_inflammation3.42339691
4MP0003436_decreased_susceptibility_to2.97856199
5MP0003172_abnormal_lysosome_physiology2.84366875
6MP0009840_abnormal_foam_cell2.75519373
7MP0002419_abnormal_innate_immunity2.74322705
8MP0000569_abnormal_digit_pigmentation2.69888552
9MP0005387_immune_system_phenotype2.60578521
10MP0001790_abnormal_immune_system2.60578521
11MP0001800_abnormal_humoral_immune2.44495102
12MP0002452_abnormal_antigen_presenting2.42643825
13MP0005000_abnormal_immune_tolerance2.42059382
14MP0006082_CNS_inflammation2.41503822
15MP0000685_abnormal_immune_system2.40263430
16MP0005025_abnormal_response_to2.25586688
17MP0003300_gastrointestinal_ulcer2.21101216
18MP0008438_abnormal_cutaneous_collagen2.10124589
19MP0005464_abnormal_platelet_physiology2.08600847
20MP0002723_abnormal_immune_serum2.07704378
21MP0002148_abnormal_hypersensitivity_rea2.05133658
22MP0003191_abnormal_cellular_cholesterol2.02722580
23MP0005257_abnormal_intraocular_pressure2.00479688
24MP0009785_altered_susceptibility_to1.98822309
25MP0002420_abnormal_adaptive_immunity1.96987802
26MP0001819_abnormal_immune_cell1.96643399
27MP0004510_myositis1.93054074
28MP0000604_amyloidosis1.89008754
29MP0005167_abnormal_blood-brain_barrier1.88426682
30MP0002138_abnormal_hepatobiliary_system1.84300890
31MP0010307_abnormal_tumor_latency1.82421096
32MP0004947_skin_inflammation1.76394998
33MP0000372_irregular_coat_pigmentation1.73711641
34MP0005174_abnormal_tail_pigmentation1.72688290
35MP0005671_abnormal_response_to1.71329327
36MP0003705_abnormal_hypodermis_morpholog1.69478454
37MP0001533_abnormal_skeleton_physiology1.64379667
38MP0003828_pulmonary_edema1.63316513
39MP0001845_abnormal_inflammatory_respons1.59824696
40MP0000371_diluted_coat_color1.59223949
41MP0002166_altered_tumor_susceptibility1.58491914
42MP0003763_abnormal_thymus_physiology1.58180114
43MP0000716_abnormal_immune_system1.53505109
44MP0003448_altered_tumor_morphology1.52461041
45MP0002405_respiratory_system_inflammati1.52038555
46MP0005310_abnormal_salivary_gland1.51585127
47MP0003566_abnormal_cell_adhesion1.51564049
48MP0000689_abnormal_spleen_morphology1.49399193
49MP0008004_abnormal_stomach_pH1.49065033
50MP0000465_gastrointestinal_hemorrhage1.48591024
51MP0002398_abnormal_bone_marrow1.47732655
52MP0003806_abnormal_nucleotide_metabolis1.46956103
53MP0003183_abnormal_peptide_metabolism1.42804989
54MP0002277_abnormal_respiratory_mucosa1.42033513
55MP0000015_abnormal_ear_pigmentation1.41360161
56MP0000858_altered_metastatic_potential1.40491934
57MP0005084_abnormal_gallbladder_morpholo1.37481579
58MP0010155_abnormal_intestine_physiology1.33702121
59MP0008469_abnormal_protein_level1.33022430
60MP0000343_altered_response_to1.32923938
61MP0005408_hypopigmentation1.31793279
62MP0006054_spinal_hemorrhage1.30467829
63MP0003724_increased_susceptibility_to1.29041303
64* MP0002429_abnormal_blood_cell1.27951032
65MP0002722_abnormal_immune_system1.27879045
66MP0003690_abnormal_glial_cell1.26726933
67MP0001853_heart_inflammation1.21959939
68MP0002998_abnormal_bone_remodeling1.19189629
69MP0001958_emphysema1.18768884
70MP0002006_tumorigenesis1.13565112
71MP0009333_abnormal_splenocyte_physiolog1.12898898
72MP0002933_joint_inflammation1.12787266
73MP0002877_abnormal_melanocyte_morpholog1.11713308
74MP0004883_abnormal_blood_vessel1.10850827
75MP0001851_eye_inflammation1.09204471
76MP0003866_abnormal_defecation1.08763985
77MP0003195_calcinosis1.07510618
78MP0009278_abnormal_bone_marrow1.05044919
79MP0002396_abnormal_hematopoietic_system1.04745548
80MP0009764_decreased_sensitivity_to0.99824511
81MP0004808_abnormal_hematopoietic_stem0.99436675
82MP0010352_gastrointestinal_tract_polyps0.99138485
83MP0004381_abnormal_hair_follicle0.98046672
84MP0001663_abnormal_digestive_system0.97712049
85MP0003045_fibrosis0.97579088
86MP0002254_reproductive_system_inflammat0.96320239
87MP0005166_decreased_susceptibility_to0.94314465
88MP0003075_altered_response_to0.94246904
89MP0003656_abnormal_erythrocyte_physiolo0.93725673
90MP0001873_stomach_inflammation0.90861519
91MP0001545_abnormal_hematopoietic_system0.89906920
92MP0005397_hematopoietic_system_phenotyp0.89906920
93MP0005164_abnormal_response_to0.89770359
94MP0005075_abnormal_melanosome_morpholog0.89571751
95MP0001986_abnormal_taste_sensitivity0.88351483
96MP0000490_abnormal_crypts_of0.87803479
97MP0002095_abnormal_skin_pigmentation0.87296366
98MP0000249_abnormal_blood_vessel0.86323197
99MP0005171_absent_coat_pigmentation0.83257960
100MP0005023_abnormal_wound_healing0.82492975
101MP0005451_abnormal_body_composition0.81626619
102MP0001919_abnormal_reproductive_system0.80109385
103MP0002132_abnormal_respiratory_system0.79986888
104MP0000609_abnormal_liver_physiology0.78763510
105MP0003091_abnormal_cell_migration0.78617360
106MP0008875_abnormal_xenobiotic_pharmacok0.78312447
107MP0005390_skeleton_phenotype0.77469661
108MP0004484_altered_response_of0.76745383
109MP0002332_abnormal_exercise_endurance0.76542128
110MP0000767_abnormal_smooth_muscle0.75442890
111MP0002928_abnormal_bile_duct0.74733826
112MP0005076_abnormal_cell_differentiation0.74154751
113MP0008260_abnormal_autophagy0.73308956
114MP0009763_increased_sensitivity_to0.73256724
115MP0003795_abnormal_bone_structure0.71330197
116MP0009765_abnormal_xenobiotic_induced0.71235209
117MP0000703_abnormal_thymus_morphology0.71213455
118MP0000230_abnormal_systemic_arterial0.70992404
119MP0002136_abnormal_kidney_physiology0.70834136
120MP0004185_abnormal_adipocyte_glucose0.70449228
121MP0001915_intracranial_hemorrhage0.67242726
122MP0003453_abnormal_keratinocyte_physiol0.67056237
123MP0005197_abnormal_uvea_morphology0.67051042
124MP0000598_abnormal_liver_morphology0.66978177
125MP0002090_abnormal_vision0.66539423
126MP0003252_abnormal_bile_duct0.64309906
127MP0005647_abnormal_sex_gland0.64108650
128MP0005410_abnormal_fertilization0.64048082
129MP0001501_abnormal_sleep_pattern0.62463655
130MP0002693_abnormal_pancreas_physiology0.62385888
131MP0003646_muscle_fatigue0.61894192

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.64934785
2Increased cerebral lipofuscin (HP:0011813)5.59622359
3Vacuolated lymphocytes (HP:0001922)5.51550649
4Recurrent abscess formation (HP:0002722)5.35309209
5Systemic lupus erythematosus (HP:0002725)5.21893488
6Dysostosis multiplex (HP:0000943)4.91258497
7Recurrent bacterial skin infections (HP:0005406)4.87018601
8Eczematoid dermatitis (HP:0000976)4.84044221
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.46660782
10Urinary glycosaminoglycan excretion (HP:0003541)4.42575356
11Mucopolysacchariduria (HP:0008155)4.42575356
12Keratoconjunctivitis (HP:0001096)4.33331635
13Abnormality of glycolipid metabolism (HP:0010969)4.27496069
14Abnormality of liposaccharide metabolism (HP:0010968)4.27496069
15Abnormality of glycosphingolipid metabolism (HP:0004343)4.27496069
16Keratoconjunctivitis sicca (HP:0001097)4.22961495
17Abnormality of polysaccharide metabolism (HP:0011012)4.20518647
18Abnormality of glycosaminoglycan metabolism (HP:0004371)4.20518647
19Abnormality of mucopolysaccharide metabolism (HP:0011020)4.20518647
20Abnormality of macrophages (HP:0004311)4.16568304
21Recurrent gram-negative bacterial infections (HP:0005420)4.02559948
22Prolonged bleeding time (HP:0003010)3.97454862
23Disinhibition (HP:0000734)3.80606057
24Loss of speech (HP:0002371)3.69501200
25Encephalitis (HP:0002383)3.51276017
26Hemoptysis (HP:0002105)3.46631727
27Autoimmune thrombocytopenia (HP:0001973)3.28107191
28Myositis (HP:0100614)3.15941299
29Asymmetric septal hypertrophy (HP:0001670)3.12948369
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.10279860
31Gangrene (HP:0100758)3.10058831
32Epistaxis (HP:0000421)3.08380636
33Recurrent skin infections (HP:0001581)3.06771661
34Glomerulonephritis (HP:0000099)3.00665471
35T lymphocytopenia (HP:0005403)2.97374798
36Axonal loss (HP:0003447)2.97343685
37Abnormality of T cell number (HP:0011839)2.96952727
38Gastrointestinal infarctions (HP:0005244)2.91972480
39Spontaneous hematomas (HP:0007420)2.91283626
40Mediastinal lymphadenopathy (HP:0100721)2.90625304
41Episodic fever (HP:0001954)2.86246827
42Spondylolisthesis (HP:0003302)2.83067467
43Cellulitis (HP:0100658)2.79241344
44Recurrent viral infections (HP:0004429)2.78844608
45Recurrent fungal infections (HP:0002841)2.78009531
46Elevated erythrocyte sedimentation rate (HP:0003565)2.77165717
47Anorexia (HP:0002039)2.74988321
48Gingivitis (HP:0000230)2.74657768
49Obstructive lung disease (HP:0006536)2.74022993
50Chronic obstructive pulmonary disease (HP:0006510)2.74022993
51Pulmonary embolism (HP:0002204)2.69324990
52Abnormality of T cells (HP:0002843)2.67244068
53Leukocytosis (HP:0001974)2.66444465
54Chronic otitis media (HP:0000389)2.64687654
55Myocardial infarction (HP:0001658)2.61197072
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60722216
57Orchitis (HP:0100796)2.58763326
58Colitis (HP:0002583)2.58582282
59Chest pain (HP:0100749)2.57314149
60Osteomyelitis (HP:0002754)2.53522109
61Alveolar cell carcinoma (HP:0006519)2.52397805
62Agnosia (HP:0010524)2.48239586
63Periodontitis (HP:0000704)2.48193467
64Thoracic kyphosis (HP:0002942)2.47242152
65Abnormality of T cell physiology (HP:0011840)2.46949610
66Pustule (HP:0200039)2.46572568
67Abnormality of the pericardium (HP:0001697)2.46520455
68Hematochezia (HP:0002573)2.44924094
69Diminished motivation (HP:0000745)2.40782465
70Inflammation of the large intestine (HP:0002037)2.40632265
71Keratitis (HP:0000491)2.40418252
72Neoplasm of the tracheobronchial system (HP:0100552)2.39594899
73Interstitial pulmonary disease (HP:0006530)2.39361294
74J-shaped sella turcica (HP:0002680)2.38942013
75Abnormal platelet volume (HP:0011876)2.37521067
76Vertigo (HP:0002321)2.36996616
77Vasculitis (HP:0002633)2.36243423
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.34475981
79Osteolytic defects of the hand bones (HP:0009699)2.34475981
80Increased IgM level (HP:0003496)2.33757953
81Petechiae (HP:0000967)2.33197247
82Meningitis (HP:0001287)2.33128272
83Abnormality of the lumbar spine (HP:0100712)2.31542030
84Apathy (HP:0000741)2.30561578
85Gastrointestinal inflammation (HP:0004386)2.30374627
86Recurrent bronchitis (HP:0002837)2.29581730
87Abnormality of the pleura (HP:0002103)2.29338201
88Polyneuropathy (HP:0001271)2.27944892
89Nasal polyposis (HP:0100582)2.27289643
90Gingival bleeding (HP:0000225)2.24077627
91Abnormality of the vasculature of the conjunctiva (HP:0008054)2.23552852
92Increased IgE level (HP:0003212)2.22165350
93Complement deficiency (HP:0004431)2.21933428
94Abnormality of complement system (HP:0005339)2.21641930
95IgM deficiency (HP:0002850)2.19222854
96Emphysema (HP:0002097)2.19183377
97Autoimmune hemolytic anemia (HP:0001890)2.16707367
98Nephritis (HP:0000123)2.16394290
99Ovoid vertebral bodies (HP:0003300)2.16051637
100Basal ganglia calcification (HP:0002135)2.15526053
101Cerebral aneurysm (HP:0004944)2.12504340
102Menorrhagia (HP:0000132)2.11669572
103Abnormality of the nasal mucosa (HP:0000433)2.11269267
104Gastrointestinal stroma tumor (HP:0100723)2.08977082
105Urticaria (HP:0001025)2.08632487
106Hepatosplenomegaly (HP:0001433)2.06619444
107Congenital sensorineural hearing impairment (HP:0008527)2.06586367
108Increased serum ferritin (HP:0003281)2.06414637
109Optic neuritis (HP:0100653)2.06026671
110Retrobulbar optic neuritis (HP:0100654)2.06026671
111Chronic mucocutaneous candidiasis (HP:0002728)2.05957311
112Recurrent cutaneous fungal infections (HP:0011370)2.05957311
113Abnormality of iron homeostasis (HP:0011031)2.04765067
114Abolished electroretinogram (ERG) (HP:0000550)2.04410254
115Cervical subluxation (HP:0003308)2.03485942
116Eosinophilia (HP:0001880)2.03263535
117Abnormality of transition element cation homeostasis (HP:0011030)2.03122009
118Glomerulopathy (HP:0100820)2.02252495
119Amyloidosis (HP:0011034)2.02057696
120Recurrent pneumonia (HP:0006532)2.01298317
121Upper motor neuron abnormality (HP:0002127)1.99746400
122Increased mean platelet volume (HP:0011877)1.99523681
123Congenital stationary night blindness (HP:0007642)1.99030914
124Abnormality of the thoracic spine (HP:0100711)1.98980340
125Conjunctival telangiectasia (HP:0000524)1.98655778
126Global brain atrophy (HP:0002283)1.98163606
127Albinism (HP:0001022)1.96484354
128Cheilitis (HP:0100825)1.95233667
129Abnormality of eosinophils (HP:0001879)1.94931415
130Arterial thrombosis (HP:0004420)1.94258018
131Pulmonary infiltrates (HP:0002113)1.93990931
132Joint hemorrhage (HP:0005261)1.93922049
133Progressive neurologic deterioration (HP:0002344)1.93687752
134Joint stiffness (HP:0001387)1.93252687
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.92980120
136Increased CSF protein (HP:0002922)1.92910580
137Recurrent lower respiratory tract infections (HP:0002783)1.92532220
138Purpura (HP:0000979)1.92231415
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89219964
140Neuronal loss in central nervous system (HP:0002529)1.88887728
141Pathologic fracture (HP:0002756)1.88087404
142Ocular albinism (HP:0001107)1.87870061
143Acne (HP:0001061)1.86164736
144Peripheral demyelination (HP:0011096)1.85865109
145IgG deficiency (HP:0004315)1.84215325
146Granulocytopenia (HP:0001913)1.82026323
147Abnormality of the endocardium (HP:0004306)1.81905592
148Inappropriate behavior (HP:0000719)1.80940255
149Agitation (HP:0000713)1.80733388
150Tinnitus (HP:0000360)1.76217138
151Attenuation of retinal blood vessels (HP:0007843)1.76024888
152Thick nail (HP:0001805)1.75178474
153Bilateral sensorineural hearing impairment (HP:0008619)1.73865004
154Impaired platelet aggregation (HP:0003540)1.73309333
155Abnormal platelet function (HP:0011869)1.73309333
156Hypergammaglobulinemia (HP:0010702)1.72045003
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70798921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.32645324
2FRK4.16707219
3BLK3.85859019
4ERN13.66333318
5MAP4K13.33220220
6KIT3.08276804
7TYK22.94088696
8TRIB32.92294214
9TAOK32.72262013
10TBK12.55842566
11RIPK42.51382350
12PKN22.35488525
13IRAK42.20699198
14MST1R2.19921704
15TGFBR22.10254178
16STK241.93437398
17CSF1R1.88903818
18ADRBK21.87500400
19SCYL21.76866413
20MAP3K131.71650991
21IRAK11.70097112
22MAP3K141.68593906
23LRRK21.68541516
24STK101.65771733
25ZAP701.63630928
26MAP2K31.63629122
27ACVR1B1.63407233
28JAK11.61995118
29JAK31.60043010
30SYK1.55438554
31TNK21.53485061
32GRK61.48928724
33IRAK31.48407468
34IKBKE1.45241599
35TIE11.42916406
36FES1.39509845
37EPHB11.38835358
38WNK31.37741421
39TTN1.36281416
40BTK1.35838224
41IKBKB1.34926623
42HCK1.30126155
43RIPK11.28799647
44PTK61.28141899
45GRK71.26437463
46NEK91.25618856
47BMX1.25269459
48PTK2B1.22744400
49RPS6KA41.16498559
50CSK1.16034619
51CAMK1D1.13580867
52MAP3K101.13329218
53ITK1.11094151
54PAK41.08518367
55TAOK11.06842977
56LYN1.06252532
57FGFR41.05409097
58YES11.04070053
59MARK31.03425116
60TEC0.99927618
61FLT30.99831238
62BMPR20.97430546
63EEF2K0.97329279
64JAK20.92952115
65LCK0.92562953
66CLK10.87290226
67EPHA30.86843928
68CDK60.86420401
69FGFR30.85047711
70SIK30.83428491
71DAPK20.83246302
72PINK10.81871686
73STK38L0.78071909
74MAP3K30.75532160
75FGR0.74310796
76FER0.72437756
77PIM10.71645362
78MST40.70482387
79NME20.69968204
80CAMK1G0.69721381
81TRPM70.69365942
82CHUK0.68588608
83PIM20.67261867
84ADRBK10.65803341
85DMPK0.65225054
86MAP3K80.65196241
87IRAK20.64127529
88MAP2K60.63630283
89GRK10.60581000
90MATK0.59802863
91ABL10.58666848
92EGFR0.58391125
93STK30.58072368
94STK40.57172767
95NUAK10.52839582
96BMPR1B0.52434501
97ZAK0.51657569
98KSR20.50932878
99MAP3K110.48975122
100MOS0.48513069
101NLK0.47879049
102SIK20.47777651
103CDK40.47700959
104PDPK10.46803012
105NEK20.46423658
106PRKCD0.46165317
107CAMKK10.45986591
108ABL20.45701725
109PDK10.45114427
110CDK120.44560867
111MAP3K50.44357385
112CAMKK20.43727929
113TESK20.43533588
114MAP3K20.42741249
115PRKCZ0.42538141
116TRIM280.41256708
117MET0.39232236
118GSK3A0.38771919
119PIK3CG0.38517742
120PRKG20.38382094
121TESK10.37046386
122MAPKAPK20.36647678
123CDK90.36064900
124PRKCH0.35192191
125OXSR10.34890204
126PRKD20.34243695
127HIPK20.33973958
128FYN0.33785314
129IGF1R0.33775017
130MAP3K60.33700740
131MAPK110.33699235
132MAP3K10.33184500
133TAOK20.33182460
134TGFBR10.32006143
135PRKCQ0.31539798
136MAPK70.31276830
137RET0.29363145
138GRK50.28841209
139MAPK120.28333294
140CDC42BPA0.27981860
141MAPKAPK30.27424220
142PRKAA20.27091093
143INSRR0.26495366
144TLK10.24639726

Predicted pathways (KEGG)

RankGene SetZ-score
1* Glycosaminoglycan degradation_Homo sapiens_hsa005313.83138943
2Lysosome_Homo sapiens_hsa041423.56001154
3Staphylococcus aureus infection_Homo sapiens_hsa051503.43615027
4Other glycan degradation_Homo sapiens_hsa005113.20647537
5Leishmaniasis_Homo sapiens_hsa051402.83543787
6Osteoclast differentiation_Homo sapiens_hsa043802.58823082
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38774117
8B cell receptor signaling pathway_Homo sapiens_hsa046622.31742420
9Autoimmune thyroid disease_Homo sapiens_hsa053202.16758831
10Pertussis_Homo sapiens_hsa051332.14349552
11Tuberculosis_Homo sapiens_hsa051522.13928276
12Antigen processing and presentation_Homo sapiens_hsa046122.10748748
13Caffeine metabolism_Homo sapiens_hsa002322.08484276
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95085340
15Type I diabetes mellitus_Homo sapiens_hsa049401.88092622
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.86022082
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75658832
18Phagosome_Homo sapiens_hsa041451.73796154
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72921855
20Malaria_Homo sapiens_hsa051441.61915627
21Measles_Homo sapiens_hsa051621.60950544
22Complement and coagulation cascades_Homo sapiens_hsa046101.60434814
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.55050225
24Toxoplasmosis_Homo sapiens_hsa051451.53321693
25Apoptosis_Homo sapiens_hsa042101.53263694
26Legionellosis_Homo sapiens_hsa051341.42691832
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39712345
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36972077
29Influenza A_Homo sapiens_hsa051641.33132935
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32465315
31Primary immunodeficiency_Homo sapiens_hsa053401.31148019
32Shigellosis_Homo sapiens_hsa051311.29507818
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29189788
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28399243
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27547261
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23582118
37Chronic myeloid leukemia_Homo sapiens_hsa052201.21173048
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20724958
39Hematopoietic cell lineage_Homo sapiens_hsa046401.19239385
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15500764
41Salmonella infection_Homo sapiens_hsa051321.14313966
42Pancreatic cancer_Homo sapiens_hsa052121.14257084
43Arachidonic acid metabolism_Homo sapiens_hsa005901.12011760
44Hepatitis B_Homo sapiens_hsa051611.09753119
45TNF signaling pathway_Homo sapiens_hsa046681.09577110
46Linoleic acid metabolism_Homo sapiens_hsa005911.08947834
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07316376
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06857837
49Rheumatoid arthritis_Homo sapiens_hsa053231.06398053
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.05225849
51Chemokine signaling pathway_Homo sapiens_hsa040621.03308860
52Herpes simplex infection_Homo sapiens_hsa051681.02081321
53Sphingolipid metabolism_Homo sapiens_hsa006000.98758404
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.95014880
55Ether lipid metabolism_Homo sapiens_hsa005650.94880042
56Acute myeloid leukemia_Homo sapiens_hsa052210.93841736
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90524030
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89855733
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89364883
60Hepatitis C_Homo sapiens_hsa051600.87742181
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87017064
62Collecting duct acid secretion_Homo sapiens_hsa049660.85434245
63Dorso-ventral axis formation_Homo sapiens_hsa043200.83968120
64Amoebiasis_Homo sapiens_hsa051460.83379242
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.82310687
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80457822
67Viral myocarditis_Homo sapiens_hsa054160.78707635
68Platelet activation_Homo sapiens_hsa046110.76982760
69Small cell lung cancer_Homo sapiens_hsa052220.75156033
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73005789
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72226984
72T cell receptor signaling pathway_Homo sapiens_hsa046600.71708848
73Renin-angiotensin system_Homo sapiens_hsa046140.71578010
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71062084
75Nitrogen metabolism_Homo sapiens_hsa009100.66600146
76Galactose metabolism_Homo sapiens_hsa000520.64688064
77VEGF signaling pathway_Homo sapiens_hsa043700.64378383
78Non-small cell lung cancer_Homo sapiens_hsa052230.61572104
79Asthma_Homo sapiens_hsa053100.60105065
80N-Glycan biosynthesis_Homo sapiens_hsa005100.59993326
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59405454
82Serotonergic synapse_Homo sapiens_hsa047260.58822853
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.58135771
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57349716
85Regulation of autophagy_Homo sapiens_hsa041400.57075229
86Pentose phosphate pathway_Homo sapiens_hsa000300.57017499
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56406636
88Endocytosis_Homo sapiens_hsa041440.54692382
89Allograft rejection_Homo sapiens_hsa053300.54323677
90HIF-1 signaling pathway_Homo sapiens_hsa040660.54215765
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54145212
92Graft-versus-host disease_Homo sapiens_hsa053320.51538492
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.50921938
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50578108
95Prolactin signaling pathway_Homo sapiens_hsa049170.50534036
96Phototransduction_Homo sapiens_hsa047440.50120488
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49509017
98Starch and sucrose metabolism_Homo sapiens_hsa005000.49471645
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48418407
100* Proteoglycans in cancer_Homo sapiens_hsa052050.48271553
101Viral carcinogenesis_Homo sapiens_hsa052030.47700656
102Epstein-Barr virus infection_Homo sapiens_hsa051690.45474103
103Insulin resistance_Homo sapiens_hsa049310.45151343
104Renal cell carcinoma_Homo sapiens_hsa052110.43439534
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42998631
106Glycerolipid metabolism_Homo sapiens_hsa005610.41930449
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.41064368
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40933292
109Ovarian steroidogenesis_Homo sapiens_hsa049130.40252063
110Sulfur metabolism_Homo sapiens_hsa009200.39998919
111African trypanosomiasis_Homo sapiens_hsa051430.39890389
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39785645
113Histidine metabolism_Homo sapiens_hsa003400.37052486
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.36946622
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36766330
116Olfactory transduction_Homo sapiens_hsa047400.36675417
117Long-term depression_Homo sapiens_hsa047300.36405792
118MicroRNAs in cancer_Homo sapiens_hsa052060.36168726
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.33866174
120Morphine addiction_Homo sapiens_hsa050320.32506563
121Focal adhesion_Homo sapiens_hsa045100.32359392
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31443051
123ABC transporters_Homo sapiens_hsa020100.31345725
124Prion diseases_Homo sapiens_hsa050200.31004618
125Colorectal cancer_Homo sapiens_hsa052100.30688498
126mTOR signaling pathway_Homo sapiens_hsa041500.30465671
127Type II diabetes mellitus_Homo sapiens_hsa049300.29658268
128Mineral absorption_Homo sapiens_hsa049780.28164992
129HTLV-I infection_Homo sapiens_hsa051660.27578308
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.26736971
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26371750
132FoxO signaling pathway_Homo sapiens_hsa040680.26189528
133p53 signaling pathway_Homo sapiens_hsa041150.25606676

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