HPS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5. Multiple transcript variants encoding two distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.75007274
2cellular response to ethanol (GO:0071361)4.34333568
3eosinophil chemotaxis (GO:0048245)4.29249030
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.26812436
5regulation of mononuclear cell migration (GO:0071675)3.96840650
6eosinophil migration (GO:0072677)3.79166649
7hepatocyte apoptotic process (GO:0097284)3.41965622
8B cell mediated immunity (GO:0019724)3.38959958
9regulation of B cell receptor signaling pathway (GO:0050855)3.38818605
10platelet dense granule organization (GO:0060155)3.37873045
11regulation of gamma-delta T cell activation (GO:0046643)3.36119602
12neutrophil activation (GO:0042119)3.20841488
13positive regulation of natural killer cell differentiation (GO:0032825)3.16926718
14antigen processing and presentation of endogenous antigen (GO:0019883)3.16392030
15pigment cell differentiation (GO:0050931)3.15179191
16signal peptide processing (GO:0006465)3.14347441
17glomerular basement membrane development (GO:0032836)3.08964233
18regulation of gamma-delta T cell differentiation (GO:0045586)3.08586751
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08340968
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08340968
21interferon-gamma-mediated signaling pathway (GO:0060333)3.07585651
22regulation of hypersensitivity (GO:0002883)3.06706386
23growth hormone receptor signaling pathway (GO:0060396)3.05771657
24NIK/NF-kappaB signaling (GO:0038061)3.01061204
25intracellular pH reduction (GO:0051452)3.00516526
26glycosphingolipid catabolic process (GO:0046479)3.00123640
27oligosaccharide catabolic process (GO:0009313)2.99771153
28granulocyte activation (GO:0036230)2.96535110
29dendritic cell chemotaxis (GO:0002407)2.96207779
30positive regulation of cellular amide metabolic process (GO:0034250)2.96126530
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95663041
32dendritic cell migration (GO:0036336)2.94676611
33response to muramyl dipeptide (GO:0032495)2.89863777
34neutrophil activation involved in immune response (GO:0002283)2.89111817
35regulation of macrophage chemotaxis (GO:0010758)2.86969945
36cytidine deamination (GO:0009972)2.86959334
37cytidine metabolic process (GO:0046087)2.86959334
38cytidine catabolic process (GO:0006216)2.86959334
39leukocyte aggregation (GO:0070486)2.86833570
40positive regulation of B cell differentiation (GO:0045579)2.85470390
41positive regulation by symbiont of host defense response (GO:0052509)2.84447733
42modulation by symbiont of host defense response (GO:0052031)2.84447733
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84447733
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84447733
45positive regulation by organism of defense response of other organism involved in symbiotic interact2.84447733
46modulation by symbiont of host immune response (GO:0052553)2.84447733
47melanocyte differentiation (GO:0030318)2.83432600
48keratan sulfate catabolic process (GO:0042340)2.82425195
49positive regulation of antigen processing and presentation (GO:0002579)2.80152427
50B cell homeostasis (GO:0001782)2.77563997
51regulation of B cell differentiation (GO:0045577)2.76598327
52kynurenine metabolic process (GO:0070189)2.74221867
53regulation of T cell tolerance induction (GO:0002664)2.73935533
54cellular response to interferon-gamma (GO:0071346)2.68693686
55tyrosine metabolic process (GO:0006570)2.68422102
56negative regulation of granulocyte differentiation (GO:0030853)2.64938376
57ceramide catabolic process (GO:0046514)2.64883740
58positive regulation of interferon-alpha production (GO:0032727)2.64414933
59regulation of lymphocyte chemotaxis (GO:1901623)2.64121108
60interferon-gamma production (GO:0032609)2.63928297
61positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.63744410
62glycolipid catabolic process (GO:0019377)2.63608316
63B cell receptor signaling pathway (GO:0050853)2.63146915
64regulation of interleukin-12 biosynthetic process (GO:0045075)2.62571243
65response to interferon-gamma (GO:0034341)2.62324844
66regulation of interferon-alpha production (GO:0032647)2.61618936
67cellular response to thyroid hormone stimulus (GO:0097067)2.60811259
68cellular response to growth hormone stimulus (GO:0071378)2.60008693
69positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.59099003
70histone H3-K4 trimethylation (GO:0080182)2.58094086
71negative regulation of interleukin-12 production (GO:0032695)2.56806431
72protein K11-linked deubiquitination (GO:0035871)2.56628788
73regulation of extracellular matrix disassembly (GO:0010715)2.56485082
74negative regulation of complement activation (GO:0045916)2.55366397
75regulation of meiosis I (GO:0060631)2.55050549
76regulation of antigen processing and presentation (GO:0002577)2.51594882
77piRNA metabolic process (GO:0034587)2.51326728
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50064130
79negative T cell selection (GO:0043383)2.48808700
80virion attachment to host cell (GO:0019062)2.48274648
81adhesion of symbiont to host cell (GO:0044650)2.48274648
82omega-hydroxylase P450 pathway (GO:0097267)2.47447706
83drug transmembrane transport (GO:0006855)2.46814873
84negative thymic T cell selection (GO:0045060)2.46247936
85regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.45510176
86lymphocyte chemotaxis (GO:0048247)2.45423083
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.45248224
88negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.45114703
89melanin biosynthetic process (GO:0042438)2.43939521
90regulation of vitamin D biosynthetic process (GO:0060556)2.43827618
91positive regulation of type 2 immune response (GO:0002830)2.43457545
92negative regulation of protein activation cascade (GO:2000258)2.43425096
93positive regulation of interferon-beta production (GO:0032728)2.43183855
94leukocyte cell-cell adhesion (GO:0007159)2.42064180
95histone H3-K9 modification (GO:0061647)2.41814533
96regulation of interferon-beta biosynthetic process (GO:0045357)2.41757557
97antigen processing and presentation via MHC class Ib (GO:0002475)2.38765415
98superoxide anion generation (GO:0042554)2.38500498
99sphingosine metabolic process (GO:0006670)2.36234819
100pinocytosis (GO:0006907)2.36189304
101macrophage activation involved in immune response (GO:0002281)2.35966394
102pH reduction (GO:0045851)2.35626980
103DNA deamination (GO:0045006)2.35616856
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.35142986
105histone mRNA catabolic process (GO:0071044)2.34869827
106cellular response to type I interferon (GO:0071357)2.34359618
107type I interferon signaling pathway (GO:0060337)2.34359618
108amino sugar catabolic process (GO:0046348)2.33981000
109positive thymic T cell selection (GO:0045059)2.33953196
110detection of other organism (GO:0098543)2.33052547
111T cell migration (GO:0072678)2.32974209
112melanin metabolic process (GO:0006582)2.32092754
113regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.32034597
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31957672
115mannose metabolic process (GO:0006013)2.31416120
116response to type I interferon (GO:0034340)2.31336976
117endosome to pigment granule transport (GO:0043485)2.31170797
118endosome to melanosome transport (GO:0035646)2.31170797
119positive regulation of monocyte chemotaxis (GO:0090026)2.31106404
120tryptophan catabolic process (GO:0006569)2.30433482
121indole-containing compound catabolic process (GO:0042436)2.30433482
122indolalkylamine catabolic process (GO:0046218)2.30433482
123regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.29797913
124respiratory burst (GO:0045730)2.29443667
125response to lipoprotein particle (GO:0055094)2.29411028
126definitive hemopoiesis (GO:0060216)2.29371202
127actin nucleation (GO:0045010)2.29099430
128negative regulation of B cell proliferation (GO:0030889)2.28818169
129macrophage chemotaxis (GO:0048246)2.28644328
130positive regulation of interleukin-1 secretion (GO:0050716)2.28307883
131regulation of natural killer cell differentiation (GO:0032823)2.28272349
132radial glial cell differentiation (GO:0060019)2.27676735
133iron ion import (GO:0097286)2.27338665
134positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27283608
135membrane raft organization (GO:0031579)2.27201934
136heterotypic cell-cell adhesion (GO:0034113)2.27196952
137diol metabolic process (GO:0034311)2.26176339
138Notch signaling involved in heart development (GO:0061314)2.25691453
139negative regulation of humoral immune response (GO:0002921)2.24486739
140production of molecular mediator of immune response (GO:0002440)2.24421032
141tryptophan metabolic process (GO:0006568)2.23807300
142phagocytosis, recognition (GO:0006910)2.23637442
143fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.23257100
144detection of molecule of bacterial origin (GO:0032490)2.22295825
145positive regulation of interleukin-1 beta secretion (GO:0050718)2.21478283
146amine catabolic process (GO:0009310)2.21292914
147cellular biogenic amine catabolic process (GO:0042402)2.21292914
148regulation of protein glycosylation (GO:0060049)2.21242731
149regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.20983283
150regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.20749938
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.20564601
152regulation of dendritic cell antigen processing and presentation (GO:0002604)2.20117626
153histone H3-K9 methylation (GO:0051567)2.19611726
154response to peptidoglycan (GO:0032494)2.18720492
155mature B cell differentiation (GO:0002335)2.18617715
156regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.17674548
157positive regulation of defense response to virus by host (GO:0002230)2.17641400
158urate metabolic process (GO:0046415)2.17597627
159negative regulation of viral genome replication (GO:0045071)2.17365593
160indolalkylamine metabolic process (GO:0006586)2.17250346
161osteoclast differentiation (GO:0030316)2.16801943
162negative regulation of phagocytosis (GO:0050765)2.16785372
163polyol catabolic process (GO:0046174)2.16560852
164detection of bacterium (GO:0016045)2.14699931
165angiogenesis involved in wound healing (GO:0060055)2.13161521
166germ cell migration (GO:0008354)2.11171586
167sphingoid metabolic process (GO:0046519)2.10076217
168myeloid cell activation involved in immune response (GO:0002275)2.09892173
169detection of biotic stimulus (GO:0009595)2.09512914
170JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.08969393
171positive regulation of toll-like receptor signaling pathway (GO:0034123)2.08929287
172hyaluronan catabolic process (GO:0030214)2.08655589
173I-kappaB phosphorylation (GO:0007252)2.08502642
174regulation of chemokine-mediated signaling pathway (GO:0070099)2.07489859
175positive regulation of natural killer cell activation (GO:0032816)2.07462753
176cellular extravasation (GO:0045123)2.07417881
177response to laminar fluid shear stress (GO:0034616)2.07302018
178histone H3-K9 demethylation (GO:0033169)2.06802532
179positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.06233988
180myeloid dendritic cell activation (GO:0001773)2.03871924
181immunoglobulin mediated immune response (GO:0016064)2.02906301
182activated T cell proliferation (GO:0050798)2.02320908
183low-density lipoprotein particle clearance (GO:0034383)2.02200889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.31505495
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.58599719
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.89210151
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72134194
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.21902461
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04349539
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88346205
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87344825
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81428142
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.76765973
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68510821
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59206003
13RUNX_20019798_ChIP-Seq_JUKART_Human2.46651840
14E2F7_22180533_ChIP-Seq_HELA_Human2.28564588
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17524373
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03511448
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94614211
18SCL_19346495_ChIP-Seq_HPC-7_Human1.93876516
19STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92913208
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90616532
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90379995
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.87405979
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80316400
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80057376
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79241051
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77377889
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73042460
28MYB_26560356_Chip-Seq_TH1_Human1.70774423
29MYB_26560356_Chip-Seq_TH2_Human1.70498806
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70488679
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67550299
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63417582
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62816286
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62684593
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.62154653
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.58705436
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.56793303
38VDR_24787735_ChIP-Seq_THP-1_Human1.56466016
39PU_27001747_Chip-Seq_BMDM_Mouse1.55376336
40SPI1_23547873_ChIP-Seq_NB4_Human1.53959461
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.53916435
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51693546
43ELK1_19687146_ChIP-ChIP_HELA_Human1.49883586
44* SPI1_23127762_ChIP-Seq_K562_Human1.47551074
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46004313
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44196901
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44134523
48MAF_26560356_Chip-Seq_TH1_Human1.43795671
49ZNF274_21170338_ChIP-Seq_K562_Hela1.43444442
50* TFEB_21752829_ChIP-Seq_HELA_Human1.43185240
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42566071
52BRD4_25478319_ChIP-Seq_HGPS_Human1.41258098
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39423564
54* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39274313
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.33165395
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.31236267
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30217170
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.28344246
59TP53_16413492_ChIP-PET_HCT116_Human1.27859146
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.26915225
61GATA1_22025678_ChIP-Seq_K562_Human1.26659081
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.26611841
63VDR_24763502_ChIP-Seq_THP-1_Human1.25608078
64* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23877235
65P300_19829295_ChIP-Seq_ESCs_Human1.23618245
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.23505911
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23375338
68ER_23166858_ChIP-Seq_MCF-7_Human1.22492047
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22313332
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21814120
71CDX2_22108803_ChIP-Seq_LS180_Human1.21803457
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21214402
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21205110
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19039749
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19039749
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18774508
77VDR_21846776_ChIP-Seq_THP-1_Human1.18335938
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17872774
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17522214
80* TP63_23658742_ChIP-Seq_EP156T_Human1.17187231
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15897946
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15853774
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.15438905
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15020619
85CBP_20019798_ChIP-Seq_JUKART_Human1.14368384
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14368384
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.13877917
88STAT3_23295773_ChIP-Seq_U87_Human1.13749404
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13594813
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13329132
91IGF1R_20145208_ChIP-Seq_DFB_Human1.13154872
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13082530
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11583974
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10847561
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10200556
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09998540
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.09748736
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09555801
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08769870
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08103891
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07387213
102GATA4_25053715_ChIP-Seq_YYC3_Human1.07376897
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.06234868
104TCF7_22412390_ChIP-Seq_EML_Mouse1.06092546
105* GATA3_27048872_Chip-Seq_THYMUS_Human1.05422880
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04226705
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03726552
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.03031557
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02848493
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.02658877
111TP53_18474530_ChIP-ChIP_U2OS_Human1.02402983
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02035286
113SMAD4_21799915_ChIP-Seq_A2780_Human1.01983398
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.01393165
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.01374400
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.01073267
117NANOG_19829295_ChIP-Seq_ESCs_Human1.01008155
118SOX2_19829295_ChIP-Seq_ESCs_Human1.01008155
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00387663
120GABP_17652178_ChIP-ChIP_JURKAT_Human1.00262505
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00178422
122TCF4_23295773_ChIP-Seq_U87_Human0.99918199
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99907170
124BCAT_22108803_ChIP-Seq_LS180_Human0.98083673
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.97855063
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97591693
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97516734
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97387808
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97336129
130GATA2_19941826_ChIP-Seq_K562_Human0.97132713
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.96654738
132P300_18555785_Chip-Seq_ESCs_Mouse0.95750607
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95728056
134* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95491569
135SMRT_27268052_Chip-Seq_Bcells_Human0.95082236
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94220731
137CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93901487
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93806306
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93490093
140CJUN_26792858_Chip-Seq_BT549_Human0.91655053
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91140827
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90625701
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90625701
144UTX_26944678_Chip-Seq_JUKART_Human0.90531976
145GATA3_26560356_Chip-Seq_TH2_Human0.89933440
146FLI1_27457419_Chip-Seq_LIVER_Mouse0.89236428
147FOXA2_19822575_ChIP-Seq_HepG2_Human0.88475534
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86736920
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85888560
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84341654
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.83235826
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82682012
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82493984
154* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81094366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.94856281
2MP0005058_abnormal_lysosome_morphology2.70326815
3MP0005360_urolithiasis2.69816389
4MP0000372_irregular_coat_pigmentation2.68432882
5MP0003300_gastrointestinal_ulcer2.49341455
6MP0003136_yellow_coat_color2.39529996
7* MP0000569_abnormal_digit_pigmentation2.38833336
8MP0005671_abnormal_response_to2.31281715
9MP0002166_altered_tumor_susceptibility2.28170847
10* MP0002095_abnormal_skin_pigmentation2.19688344
11MP0003806_abnormal_nucleotide_metabolis2.17113770
12MP0009840_abnormal_foam_cell2.09322773
13MP0002396_abnormal_hematopoietic_system2.08015238
14MP0002419_abnormal_innate_immunity2.05501138
15MP0003436_decreased_susceptibility_to2.04224508
16MP0001800_abnormal_humoral_immune2.03398594
17MP0002452_abnormal_antigen_presenting1.97757642
18MP0005387_immune_system_phenotype1.97550665
19MP0001790_abnormal_immune_system1.97550665
20MP0002138_abnormal_hepatobiliary_system1.90961602
21MP0001873_stomach_inflammation1.87044649
22MP0005000_abnormal_immune_tolerance1.86331659
23MP0000685_abnormal_immune_system1.76279993
24MP0002723_abnormal_immune_serum1.75119054
25MP0003191_abnormal_cellular_cholesterol1.72982825
26MP0002006_tumorigenesis1.70741108
27* MP0000371_diluted_coat_color1.69232576
28* MP0005174_abnormal_tail_pigmentation1.68333430
29MP0002420_abnormal_adaptive_immunity1.67375510
30MP0004381_abnormal_hair_follicle1.67098895
31MP0000427_abnormal_hair_cycle1.66977257
32MP0001819_abnormal_immune_cell1.66894869
33* MP0005025_abnormal_response_to1.65326250
34MP0003172_abnormal_lysosome_physiology1.61535660
35MP0003183_abnormal_peptide_metabolism1.59448946
36MP0002139_abnormal_hepatobiliary_system1.59046806
37MP0000604_amyloidosis1.57779167
38MP0010155_abnormal_intestine_physiology1.56914522
39MP0003195_calcinosis1.52596011
40MP0002009_preneoplasia1.51788687
41MP0001958_emphysema1.49266786
42MP0004264_abnormal_extraembryonic_tissu1.46276564
43MP0003045_fibrosis1.46080369
44MP0003763_abnormal_thymus_physiology1.45345348
45* MP0005464_abnormal_platelet_physiology1.42199028
46MP0002148_abnormal_hypersensitivity_rea1.41453641
47MP0008438_abnormal_cutaneous_collagen1.40687120
48MP0000465_gastrointestinal_hemorrhage1.39059731
49MP0003252_abnormal_bile_duct1.37627090
50MP0009785_altered_susceptibility_to1.34539897
51MP0005451_abnormal_body_composition1.33295989
52MP0000716_abnormal_immune_system1.32565217
53* MP0002398_abnormal_bone_marrow1.29586411
54MP0002998_abnormal_bone_remodeling1.29530556
55MP0005408_hypopigmentation1.27068522
56MP0001845_abnormal_inflammatory_respons1.26038946
57* MP0001324_abnormal_eye_pigmentation1.24867540
58MP0002405_respiratory_system_inflammati1.24440438
59* MP0002136_abnormal_kidney_physiology1.23679091
60MP0009697_abnormal_copulation1.22029985
61MP0004947_skin_inflammation1.21614619
62MP0002877_abnormal_melanocyte_morpholog1.21536228
63* MP0002075_abnormal_coat/hair_pigmentati1.19301805
64MP0003303_peritoneal_inflammation1.19045218
65MP0004019_abnormal_vitamin_homeostasis1.18000708
66MP0010352_gastrointestinal_tract_polyps1.16811875
67* MP0000015_abnormal_ear_pigmentation1.16557530
68MP0005075_abnormal_melanosome_morpholog1.16246940
69MP0001853_heart_inflammation1.14229977
70MP0000689_abnormal_spleen_morphology1.14194498
71MP0005365_abnormal_bile_salt1.14076209
72MP0002102_abnormal_ear_morphology1.13268828
73MP0009643_abnormal_urine_homeostasis1.11479506
74MP0001661_extended_life_span1.09916934
75MP0003566_abnormal_cell_adhesion1.09880562
76MP0000566_synostosis1.09003235
77MP0002090_abnormal_vision1.07907887
78* MP0002429_abnormal_blood_cell1.07148101
79MP0001533_abnormal_skeleton_physiology1.07112151
80MP0000490_abnormal_crypts_of1.06866701
81MP0002837_dystrophic_cardiac_calcinosis1.06592275
82MP0005257_abnormal_intraocular_pressure1.03023104
83MP0002722_abnormal_immune_system1.02301684
84* MP0001186_pigmentation_phenotype1.02028274
85MP0005666_abnormal_adipose_tissue1.01394706
86MP0009764_decreased_sensitivity_to1.01075005
87MP0008469_abnormal_protein_level0.99675694
88MP0005171_absent_coat_pigmentation0.99463975
89MP0002254_reproductive_system_inflammat0.99258644
90MP0003091_abnormal_cell_migration0.98665413
91MP0003866_abnormal_defecation0.97622326
92MP0000343_altered_response_to0.96862383
93MP0000609_abnormal_liver_physiology0.96735469
94MP0003448_altered_tumor_morphology0.96329625
95MP0003724_increased_susceptibility_to0.95806895
96MP0010329_abnormal_lipoprotein_level0.95268442
97MP0010678_abnormal_skin_adnexa0.94071068
98MP0005670_abnormal_white_adipose0.92070227
99MP0003718_maternal_effect0.90793828
100MP0002933_joint_inflammation0.90171103
101MP0005395_other_phenotype0.89857490
102MP0004808_abnormal_hematopoietic_stem0.89728573
103MP0003186_abnormal_redox_activity0.89674834
104MP0003878_abnormal_ear_physiology0.89660076
105MP0005377_hearing/vestibular/ear_phenot0.89660076
106MP0006082_CNS_inflammation0.89204267
107MP0000383_abnormal_hair_follicle0.88455040
108MP0009763_increased_sensitivity_to0.87780169
109MP0003950_abnormal_plasma_membrane0.87638168
110MP0006054_spinal_hemorrhage0.85297725
111MP0003787_abnormal_imprinting0.85112025
112MP0001666_abnormal_nutrient_absorption0.84319089
113MP0005164_abnormal_response_to0.82829349
114MP0003453_abnormal_keratinocyte_physiol0.82419307
115MP0008057_abnormal_DNA_replication0.82216296
116MP0005310_abnormal_salivary_gland0.81957507
117MP0003656_abnormal_erythrocyte_physiolo0.80420453
118MP0005085_abnormal_gallbladder_physiolo0.80042686
119MP0005332_abnormal_amino_acid0.79543821
120MP0001663_abnormal_digestive_system0.79172778
121MP0000358_abnormal_cell_content/0.77958567
122MP0008260_abnormal_autophagy0.77613594
123MP0008875_abnormal_xenobiotic_pharmacok0.76877459
124MP0002168_other_aberrant_phenotype0.76563154
125MP0010234_abnormal_vibrissa_follicle0.75437284
126MP0004134_abnormal_chest_morphology0.74361845
127MP0003646_muscle_fatigue0.72988386
128MP0010307_abnormal_tumor_latency0.72618160
129MP0000920_abnormal_myelination0.71132447
130MP0009765_abnormal_xenobiotic_induced0.67151391
131MP0002060_abnormal_skin_morphology0.66449183
132MP0005253_abnormal_eye_physiology0.65843435
133MP0003075_altered_response_to0.65841777
134MP0010094_abnormal_chromosome_stability0.64429686

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.70465783
2Abnormality of liposaccharide metabolism (HP:0010968)5.70465783
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.70465783
4Systemic lupus erythematosus (HP:0002725)3.91270893
5Eczematoid dermatitis (HP:0000976)3.68637430
6Glomerulonephritis (HP:0000099)3.68098370
7Generalized hypopigmentation of hair (HP:0011358)3.61188686
8Recurrent abscess formation (HP:0002722)3.54836233
9Fair hair (HP:0002286)3.41578210
10Bilateral sensorineural hearing impairment (HP:0008619)3.27545905
11Recurrent fungal infections (HP:0002841)3.26249192
12White forelock (HP:0002211)3.21884618
13Recurrent bacterial skin infections (HP:0005406)3.13741538
14Patchy hypopigmentation of hair (HP:0011365)3.09758078
15Recurrent viral infections (HP:0004429)2.78375332
16Spinal cord lesions (HP:0100561)2.77665533
17Syringomyelia (HP:0003396)2.77665533
18Abnormality of the fingertips (HP:0001211)2.75756386
19Blue irides (HP:0000635)2.72999468
20Recurrent gram-negative bacterial infections (HP:0005420)2.72930356
21Cutaneous melanoma (HP:0012056)2.72320020
22Hypoplasia of the fovea (HP:0007750)2.71720384
23Aplasia/Hypoplasia of the fovea (HP:0008060)2.71720384
24* Ocular albinism (HP:0001107)2.65722301
25Gingivitis (HP:0000230)2.65299646
26Chronic mucocutaneous candidiasis (HP:0002728)2.63252561
27Recurrent cutaneous fungal infections (HP:0011370)2.63252561
28* Generalized hypopigmentation (HP:0007513)2.63037517
29Recurrent skin infections (HP:0001581)2.58082274
30Inflammation of the large intestine (HP:0002037)2.52019153
31Lower limb hyperreflexia (HP:0002395)2.49919348
32Thick nail (HP:0001805)2.49188464
33Abnormality of macrophages (HP:0004311)2.48758708
34Abnormality of the lumbar spine (HP:0100712)2.48045217
35Joint hemorrhage (HP:0005261)2.47387760
36Autoimmune hemolytic anemia (HP:0001890)2.45605830
37Nephritis (HP:0000123)2.45590850
38Increased cerebral lipofuscin (HP:0011813)2.42864705
39Colitis (HP:0002583)2.39652904
40Periodontitis (HP:0000704)2.39237474
41Chronic diarrhea (HP:0002028)2.36572650
42Loss of speech (HP:0002371)2.35106461
43Spontaneous hematomas (HP:0007420)2.34982632
44Complement deficiency (HP:0004431)2.34344410
45Chromsome breakage (HP:0040012)2.34109628
46Cellulitis (HP:0100658)2.32626461
47Congenital sensorineural hearing impairment (HP:0008527)2.31324913
48Abnormality of the fovea (HP:0000493)2.31163786
49Osteomyelitis (HP:0002754)2.30136525
50Gingival bleeding (HP:0000225)2.29687083
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28260863
52Epidermoid cyst (HP:0200040)2.26473831
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.23874876
54Tetany (HP:0001281)2.23699695
55Tubular atrophy (HP:0000092)2.21723625
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.21331377
57Osteolytic defects of the hand bones (HP:0009699)2.21331377
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20755544
59Gastrointestinal inflammation (HP:0004386)2.20199118
60Aortic dissection (HP:0002647)2.19955606
61IgM deficiency (HP:0002850)2.19244719
62Abnormality of the prostate (HP:0008775)2.17010165
63Abnormality of polysaccharide metabolism (HP:0011012)2.16167329
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16167329
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16167329
66Autoimmune thrombocytopenia (HP:0001973)2.15364617
67Myositis (HP:0100614)2.15250256
68Persistence of primary teeth (HP:0006335)2.14447186
69Aplasia/Hypoplasia of the macula (HP:0008059)2.14038281
70Metabolic alkalosis (HP:0200114)2.13553736
71Spinal muscular atrophy (HP:0007269)2.11667901
72Optic neuritis (HP:0100653)2.09108880
73Retrobulbar optic neuritis (HP:0100654)2.09108880
74Hyperactive renin-angiotensin system (HP:0000841)2.07517823
75Meningitis (HP:0001287)2.06757544
76Myocardial infarction (HP:0001658)2.06092812
77Absent frontal sinuses (HP:0002688)2.05692371
78Chronic obstructive pulmonary disease (HP:0006510)2.05571992
79Obstructive lung disease (HP:0006536)2.05571992
80Urinary glycosaminoglycan excretion (HP:0003541)2.05233677
81Mucopolysacchariduria (HP:0008155)2.05233677
82* Albinism (HP:0001022)2.03406898
83Chronic otitis media (HP:0000389)2.03374121
84Dysostosis multiplex (HP:0000943)2.03238641
85Vasculitis (HP:0002633)2.02559356
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.02300590
87T lymphocytopenia (HP:0005403)2.01292312
88Global brain atrophy (HP:0002283)2.00733616
89Neoplasm of head and neck (HP:0012288)1.99121270
90Esophageal neoplasm (HP:0100751)1.99121270
91Orchitis (HP:0100796)1.98610536
92Agnosia (HP:0010524)1.97142084
93Mediastinal lymphadenopathy (HP:0100721)1.96882802
94Pulmonary infiltrates (HP:0002113)1.96681262
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.96055004
96* Iris hypopigmentation (HP:0007730)1.95738178
97Abnormality of chloride homeostasis (HP:0011422)1.95170445
98Metaphyseal irregularity (HP:0003025)1.94448272
99Thin bony cortex (HP:0002753)1.94391092
100Prolonged bleeding time (HP:0003010)1.94248174
101Increased IgE level (HP:0003212)1.93340501
102Hematochezia (HP:0002573)1.92664609
103Disproportionate short-trunk short stature (HP:0003521)1.92596715
104Disinhibition (HP:0000734)1.92481943
105Thoracic kyphosis (HP:0002942)1.91902672
106Agammaglobulinemia (HP:0004432)1.91586115
107Interstitial pulmonary disease (HP:0006530)1.90867193
108Aortic aneurysm (HP:0004942)1.90854802
109Vacuolated lymphocytes (HP:0001922)1.89291881
110Abnormality of T cell number (HP:0011839)1.88794435
111Abnormal platelet volume (HP:0011876)1.88369221
112Prostate neoplasm (HP:0100787)1.88140064
113Recurrent pneumonia (HP:0006532)1.86721546
114Abnormality of proline metabolism (HP:0010907)1.86596617
115Hydroxyprolinuria (HP:0003080)1.86596617
116Aplasia/Hypoplasia affecting the retina (HP:0008061)1.86250274
117J-shaped sella turcica (HP:0002680)1.86144680
118Eosinophilia (HP:0001880)1.85834910
119Hypomagnesemia (HP:0002917)1.85265921
120Tubulointerstitial fibrosis (HP:0005576)1.84805800
121Conjugated hyperbilirubinemia (HP:0002908)1.84753005
122Abnormality of the renal cortex (HP:0011035)1.84291044
123Recurrent bronchitis (HP:0002837)1.82533753
124Hemoptysis (HP:0002105)1.82169110
125Progressive inability to walk (HP:0002505)1.81940573
126Hypoplasia of the odontoid process (HP:0003311)1.81805211
127Polyuria (HP:0000103)1.81492071
128Polyneuropathy (HP:0001271)1.79870481
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79297671
130Elevated erythrocyte sedimentation rate (HP:0003565)1.78560136
131Thyroiditis (HP:0100646)1.77614858
132Renal cortical cysts (HP:0000803)1.77491677
133Hypokalemic alkalosis (HP:0001949)1.77013654
134Bile duct proliferation (HP:0001408)1.76104106
135Abnormal biliary tract physiology (HP:0012439)1.76104106
136Abnormality of DNA repair (HP:0003254)1.75994172
137Ectopic kidney (HP:0000086)1.75099692
138Lymphopenia (HP:0001888)1.74868007
139Pulmonary fibrosis (HP:0002206)1.74751885
140Ureteral obstruction (HP:0006000)1.73840086
141Abnormal urine output (HP:0012590)1.73568187
142Polydipsia (HP:0001959)1.73387689
143Abnormal drinking behavior (HP:0030082)1.73387689
144Abnormality of renal excretion (HP:0011036)1.72008885
145Premature loss of primary teeth (HP:0006323)1.71526817
146Protuberant abdomen (HP:0001538)1.71360208
147IgA deficiency (HP:0002720)1.71234732
148Pustule (HP:0200039)1.70800575
149Xerostomia (HP:0000217)1.70394330
150Arterial tortuosity (HP:0005116)1.70069758
151Leukocytosis (HP:0001974)1.69094547
152Cheilitis (HP:0100825)1.68698304
153Ureteral stenosis (HP:0000071)1.68658464
154Restrictive lung disease (HP:0002091)1.68632381
155Hypoproteinemia (HP:0003075)1.68562070
156Beaking of vertebral bodies (HP:0004568)1.68349397
157Intrahepatic cholestasis (HP:0001406)1.65937173
158Poor head control (HP:0002421)1.64232945
159Increased CSF protein (HP:0002922)1.63751079
160Abnormality of complement system (HP:0005339)1.63745950
161Hyperventilation (HP:0002883)1.62808955
162Abnormality of the basal ganglia (HP:0002134)1.62679833
163Premature graying of hair (HP:0002216)1.62181915
164Abnormality of T cells (HP:0002843)1.61181861
165Hypokinesia (HP:0002375)1.59961193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.57920749
2ACVR1B3.54289032
3IRAK43.47486686
4MAP4K12.74229724
5EPHB12.72507101
6STK38L2.64639520
7FGFR42.60671680
8EIF2AK32.58970176
9MAP3K142.55056887
10EPHA32.40133806
11KIT2.26873285
12BRSK22.24814804
13PDK22.16249167
14BMPR22.12113946
15TYK22.12080632
16TGFBR22.09487001
17NUAK12.07833850
18ADRBK22.06412410
19STK102.02871490
20IRAK11.95862439
21JAK11.88116041
22FGFR31.87454035
23CSK1.82173608
24JAK31.79204512
25CDK121.73573520
26GRK71.70934951
27MAP3K131.69345892
28BMPR1B1.68159402
29TXK1.63888589
30BLK1.55340875
31MAP4K21.52047837
32PBK1.51924167
33ERBB41.50223695
34PTK61.46640167
35TAOK31.43558477
36MST1R1.42334039
37CSF1R1.41251641
38STK31.40117470
39MARK31.38616488
40BTK1.38292470
41CAMKK21.37895662
42NLK1.34437303
43WEE11.33057000
44CLK11.29092717
45ITK1.25569558
46TRPM71.22363578
47IKBKB1.20069787
48CDK91.17307463
49CAMK1D1.16386058
50NEK91.16008475
51IKBKE1.15935310
52OXSR11.12606084
53WNK41.09787942
54CHUK1.08327399
55BRD41.07126796
56RIPK41.04583831
57HCK1.04166059
58IRAK21.02374809
59TEC1.01896503
60STK390.99044747
61INSRR0.98156412
62CDK60.94893867
63EIF2AK10.94586860
64LCK0.94035771
65FER0.92448760
66TNK20.91997299
67LATS10.89525797
68TLK10.86010788
69NEK60.84714753
70STK40.83284423
71ZAK0.82936323
72TBK10.82371912
73WNK30.79886580
74PIM10.79811208
75GRK60.79569579
76TTK0.79553501
77TGFBR10.79142189
78PRKCQ0.78065299
79PRKAA20.77903556
80MAP3K20.77234182
81LYN0.77212701
82MST40.77121433
83LRRK20.76016762
84PDGFRB0.75990628
85CAMK1G0.72830317
86FGFR20.72557615
87WNK10.70804438
88SIK10.69755335
89YES10.69652796
90SCYL20.69354032
91MAP3K50.68887622
92PLK20.68054282
93JAK20.67146490
94ERBB30.66684117
95FGR0.66368510
96MAPK150.66052133
97MAPKAPK30.64889441
98TTN0.64600170
99AKT30.64213064
100PIK3CG0.64072354
101MET0.63912871
102SYK0.61716069
103MAP3K120.60539957
104PTK2B0.60427889
105ICK0.60362073
106ZAP700.59343396
107ABL10.56410112
108FLT30.55197691
109GRK10.54382649
110ERN10.51362907
111STK240.51239432
112MAP2K30.47608489
113CDK40.47334728
114MATK0.47331421
115PRPF4B0.47084577
116MELK0.46420549
117NEK20.46399020
118MAP3K80.46002184
119LATS20.45992867
120DDR20.45316578
121MAP3K100.45112157
122MOS0.44353037
123BMX0.44150353
124ATR0.43769674
125MUSK0.42622287
126SGK30.41861530
127GSK3A0.41170306
128FRK0.41009293
129IGF1R0.39548425
130ADRBK10.39413688
131PRKCH0.39351285
132PLK40.39256057
133NEK10.37955510
134DYRK1B0.37853801
135HIPK20.37462178
136MAPK70.37106775
137EIF2AK20.36752556
138SGK20.36294220
139CSNK1A1L0.36287765
140PKN10.34561027
141MAPK110.34204705
142CDK30.34040301
143MAP3K30.33572224
144EGFR0.31608951
145INSR0.30019947
146PRKACB0.29885432

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.37477562
2Allograft rejection_Homo sapiens_hsa053303.26670620
3Autoimmune thyroid disease_Homo sapiens_hsa053203.10607113
4Type I diabetes mellitus_Homo sapiens_hsa049402.57335807
5Rheumatoid arthritis_Homo sapiens_hsa053232.46204597
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.14097777
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.11711051
8Lysine degradation_Homo sapiens_hsa003102.00961265
9Primary immunodeficiency_Homo sapiens_hsa053401.82965768
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77975534
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76953191
12Caffeine metabolism_Homo sapiens_hsa002321.76036341
13Staphylococcus aureus infection_Homo sapiens_hsa051501.74650043
14Other glycan degradation_Homo sapiens_hsa005111.73827420
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.69918041
16Vitamin digestion and absorption_Homo sapiens_hsa049771.69007137
17B cell receptor signaling pathway_Homo sapiens_hsa046621.66966796
18Leishmaniasis_Homo sapiens_hsa051401.66827602
19Phagosome_Homo sapiens_hsa041451.65375528
20Osteoclast differentiation_Homo sapiens_hsa043801.63513751
21Histidine metabolism_Homo sapiens_hsa003401.62083445
22Non-homologous end-joining_Homo sapiens_hsa034501.60459316
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58904763
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58456191
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.50284095
26Hematopoietic cell lineage_Homo sapiens_hsa046401.48483536
27Measles_Homo sapiens_hsa051621.45237811
28Steroid biosynthesis_Homo sapiens_hsa001001.40190487
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38503124
30Systemic lupus erythematosus_Homo sapiens_hsa053221.36041481
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.33787903
32Sphingolipid metabolism_Homo sapiens_hsa006001.31909274
33Tryptophan metabolism_Homo sapiens_hsa003801.30333805
34ABC transporters_Homo sapiens_hsa020101.29870414
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29543122
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25791535
37Lysosome_Homo sapiens_hsa041421.23902337
38beta-Alanine metabolism_Homo sapiens_hsa004101.22792399
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22344959
40Fatty acid degradation_Homo sapiens_hsa000711.20883211
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18504675
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18237946
43Complement and coagulation cascades_Homo sapiens_hsa046101.14771905
44Toxoplasmosis_Homo sapiens_hsa051451.09174406
45Sulfur metabolism_Homo sapiens_hsa009201.08334770
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05196835
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03962862
48Antigen processing and presentation_Homo sapiens_hsa046121.03317946
49PPAR signaling pathway_Homo sapiens_hsa033201.01453731
50Small cell lung cancer_Homo sapiens_hsa052221.01094693
51Malaria_Homo sapiens_hsa051441.00089978
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98255384
53Tuberculosis_Homo sapiens_hsa051520.97868084
54Renin-angiotensin system_Homo sapiens_hsa046140.95666501
55Peroxisome_Homo sapiens_hsa041460.95132758
56Starch and sucrose metabolism_Homo sapiens_hsa005000.94657844
57One carbon pool by folate_Homo sapiens_hsa006700.94610508
58Fanconi anemia pathway_Homo sapiens_hsa034600.93695038
59T cell receptor signaling pathway_Homo sapiens_hsa046600.93569352
60Apoptosis_Homo sapiens_hsa042100.92327735
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91354394
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.91342321
63Hepatitis C_Homo sapiens_hsa051600.88077217
64Pancreatic cancer_Homo sapiens_hsa052120.83984630
65Influenza A_Homo sapiens_hsa051640.82870145
66Mineral absorption_Homo sapiens_hsa049780.82496968
67Pertussis_Homo sapiens_hsa051330.82381315
68Protein digestion and absorption_Homo sapiens_hsa049740.81516712
69TNF signaling pathway_Homo sapiens_hsa046680.80489924
70Acute myeloid leukemia_Homo sapiens_hsa052210.79937204
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78847426
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78429505
73Chemokine signaling pathway_Homo sapiens_hsa040620.77534901
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77461820
75Dorso-ventral axis formation_Homo sapiens_hsa043200.76143990
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74970614
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72191896
78Herpes simplex infection_Homo sapiens_hsa051680.71899950
79N-Glycan biosynthesis_Homo sapiens_hsa005100.71779478
80Fatty acid elongation_Homo sapiens_hsa000620.71617590
81Glycerolipid metabolism_Homo sapiens_hsa005610.71120756
82Chronic myeloid leukemia_Homo sapiens_hsa052200.70261378
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69036305
84Fatty acid metabolism_Homo sapiens_hsa012120.67586126
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.67138929
86MicroRNAs in cancer_Homo sapiens_hsa052060.66857216
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66361194
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66190309
89Basal transcription factors_Homo sapiens_hsa030220.65511566
90Inositol phosphate metabolism_Homo sapiens_hsa005620.65451939
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64845700
92Hepatitis B_Homo sapiens_hsa051610.64394452
93Homologous recombination_Homo sapiens_hsa034400.63749256
94Proteasome_Homo sapiens_hsa030500.63083822
95Shigellosis_Homo sapiens_hsa051310.61605258
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61076358
97Chemical carcinogenesis_Homo sapiens_hsa052040.60746209
98Protein export_Homo sapiens_hsa030600.59767342
99Salmonella infection_Homo sapiens_hsa051320.59732490
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59614212
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59543811
102ECM-receptor interaction_Homo sapiens_hsa045120.59261675
103Prostate cancer_Homo sapiens_hsa052150.58412833
104Graft-versus-host disease_Homo sapiens_hsa053320.58265920
105Viral myocarditis_Homo sapiens_hsa054160.57385260
106Adherens junction_Homo sapiens_hsa045200.57139347
107Insulin resistance_Homo sapiens_hsa049310.57006892
108Fat digestion and absorption_Homo sapiens_hsa049750.56209507
109Notch signaling pathway_Homo sapiens_hsa043300.55994468
110Arginine and proline metabolism_Homo sapiens_hsa003300.55941387
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55939625
112Linoleic acid metabolism_Homo sapiens_hsa005910.55377238
113Selenocompound metabolism_Homo sapiens_hsa004500.55137743
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.54997457
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54846926
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51530789
117Choline metabolism in cancer_Homo sapiens_hsa052310.51216848
118FoxO signaling pathway_Homo sapiens_hsa040680.50895481
119Arachidonic acid metabolism_Homo sapiens_hsa005900.50659808
120Platelet activation_Homo sapiens_hsa046110.50556259
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50447274
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49814272
123Legionellosis_Homo sapiens_hsa051340.49369132
124Propanoate metabolism_Homo sapiens_hsa006400.48389920
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.48172939
126Retinol metabolism_Homo sapiens_hsa008300.47076044
127p53 signaling pathway_Homo sapiens_hsa041150.45268418
128Butanoate metabolism_Homo sapiens_hsa006500.40137508
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40112623
130Collecting duct acid secretion_Homo sapiens_hsa049660.38618200
131Galactose metabolism_Homo sapiens_hsa000520.35929896
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35860566
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35853486
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35719433
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34140810
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32528368
137Epstein-Barr virus infection_Homo sapiens_hsa051690.29793743

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