HPS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a potential clathrin-binding motif, consensus dileucine signals, and tyrosine-based sorting signals for targeting to vesicles of lysosomal lineage. The encoded protein may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.97078574
2regulation of interferon-beta biosynthetic process (GO:0045357)5.79377091
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.29637173
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.29637173
5modulation by symbiont of host immune response (GO:0052553)5.29637173
6positive regulation by symbiont of host defense response (GO:0052509)5.29637173
7modulation by symbiont of host defense response (GO:0052031)5.29637173
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.29637173
9regulation of B cell receptor signaling pathway (GO:0050855)5.08752111
10positive regulation of gamma-delta T cell activation (GO:0046645)4.85886496
11B cell receptor signaling pathway (GO:0050853)4.65419407
12microglial cell activation (GO:0001774)4.54613069
13positive regulation of interferon-alpha production (GO:0032727)4.46908918
14macrophage activation involved in immune response (GO:0002281)4.39043378
15nuclear pore complex assembly (GO:0051292)4.29283315
16neutrophil activation involved in immune response (GO:0002283)4.28868773
17antigen processing and presentation of endogenous antigen (GO:0019883)4.22988651
18regulation of interferon-alpha production (GO:0032647)4.20117364
19negative regulation of cell killing (GO:0031342)4.10661058
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.10661058
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87611072
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87611072
23respiratory burst (GO:0045730)3.81887358
24neutrophil activation (GO:0042119)3.80773077
25B cell homeostasis (GO:0001782)3.79773908
26nuclear pore organization (GO:0006999)3.79648257
27response to host immune response (GO:0052572)3.77396933
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.77396933
29regulation of B cell differentiation (GO:0045577)3.71805338
30response to muramyl dipeptide (GO:0032495)3.70239059
31positive regulation of mast cell degranulation (GO:0043306)3.62765238
32positive regulation of mast cell activation involved in immune response (GO:0033008)3.62765238
33germinal center formation (GO:0002467)3.60779221
34B cell proliferation (GO:0042100)3.60223875
35I-kappaB phosphorylation (GO:0007252)3.59207083
36positive regulation of B cell differentiation (GO:0045579)3.58664714
37positive regulation of antigen processing and presentation (GO:0002579)3.54650717
38response to peptidoglycan (GO:0032494)3.51662244
39negative regulation of B cell proliferation (GO:0030889)3.51540541
40macrophage activation (GO:0042116)3.47769411
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46808370
42positive regulation of leukocyte degranulation (GO:0043302)3.45912311
43granulocyte activation (GO:0036230)3.42366156
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40003038
45response to host (GO:0075136)3.40003038
46response to host defenses (GO:0052200)3.40003038
47neutrophil mediated immunity (GO:0002446)3.36061520
48positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.32734204
49positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.32320893
50hepatocyte apoptotic process (GO:0097284)3.30937526
51myeloid cell activation involved in immune response (GO:0002275)3.28371177
52interferon-gamma production (GO:0032609)3.28143015
53pinocytosis (GO:0006907)3.26906323
54regulation of interleukin-12 biosynthetic process (GO:0045075)3.26835398
55mitotic sister chromatid cohesion (GO:0007064)3.26136804
56iron ion import (GO:0097286)3.25494290
57cellular response to exogenous dsRNA (GO:0071360)3.23814270
58regulation of alpha-beta T cell proliferation (GO:0046640)3.22420074
59leukocyte aggregation (GO:0070486)3.21514704
60positive regulation of mast cell activation (GO:0033005)3.18630000
61regulation of gamma-delta T cell activation (GO:0046643)3.16520204
62positive regulation of interferon-beta production (GO:0032728)3.15827878
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15032829
64immunoglobulin mediated immune response (GO:0016064)3.14258296
65interferon-gamma-mediated signaling pathway (GO:0060333)3.13082574
66pore complex assembly (GO:0046931)3.12168643
67embryonic process involved in female pregnancy (GO:0060136)3.12026732
68regulation of mast cell activation (GO:0033003)3.08939149
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07395796
70negative regulation of granulocyte differentiation (GO:0030853)3.06551929
71mature B cell differentiation (GO:0002335)3.06187216
72myeloid dendritic cell activation (GO:0001773)3.05746252
73regulation of mast cell degranulation (GO:0043304)3.05664580
74regulation of B cell proliferation (GO:0030888)3.05523119
75regulation of gamma-delta T cell differentiation (GO:0045586)3.05018555
76COPI coating of Golgi vesicle (GO:0048205)3.02881497
77Golgi transport vesicle coating (GO:0048200)3.02881497
78regulation of mast cell activation involved in immune response (GO:0033006)3.02440108
79cellular extravasation (GO:0045123)3.01431857
80DNA duplex unwinding (GO:0032508)2.99055856
81cellular response to interferon-beta (GO:0035458)2.98025730
82oligosaccharide catabolic process (GO:0009313)2.96642371
83negative regulation of interleukin-12 production (GO:0032695)2.95392767
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95124211
85tolerance induction (GO:0002507)2.94055920
86myeloid leukocyte activation (GO:0002274)2.90945007
87positive regulation of B cell proliferation (GO:0030890)2.90474423
88positive thymic T cell selection (GO:0045059)2.89946564
89regulation of antigen processing and presentation (GO:0002577)2.89101234
90DNA geometric change (GO:0032392)2.88384150
91negative regulation of mast cell activation (GO:0033004)2.88024474
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87536479
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.87536479
94regulation of translation, ncRNA-mediated (GO:0045974)2.87536479
95regulation of germinal center formation (GO:0002634)2.86743484
96DNA unwinding involved in DNA replication (GO:0006268)2.86444398
97L-serine metabolic process (GO:0006563)2.86423082
98regulation of helicase activity (GO:0051095)2.85808004
99positive regulation of interleukin-12 production (GO:0032735)2.84629221
100G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.82068373
101positive regulation of cellular amide metabolic process (GO:0034250)2.82029921
102regulation of T cell tolerance induction (GO:0002664)2.80969206
103positive regulation of developmental pigmentation (GO:0048087)2.80122945
104defense response to protozoan (GO:0042832)2.79540328
105lymphocyte homeostasis (GO:0002260)2.79349553
106ribosome assembly (GO:0042255)2.79294281
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78986274
108glycosphingolipid catabolic process (GO:0046479)2.78644145
109myeloid dendritic cell differentiation (GO:0043011)2.78409426
110regulation of interferon-gamma biosynthetic process (GO:0045072)2.76978002
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76033690
112lymphocyte proliferation (GO:0046651)2.73208805
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72745308
114mast cell activation (GO:0045576)2.72294361
115response to type I interferon (GO:0034340)2.72085184
116positive regulation of B cell activation (GO:0050871)2.70929543
117type I interferon signaling pathway (GO:0060337)2.70796809
118cellular response to type I interferon (GO:0071357)2.70796809
119mononuclear cell proliferation (GO:0032943)2.70709842
120leukocyte cell-cell adhesion (GO:0007159)2.68714649
121production of molecular mediator involved in inflammatory response (GO:0002532)2.67931255
122establishment of integrated proviral latency (GO:0075713)2.65987188
123positive regulation of SMAD protein import into nucleus (GO:0060391)2.65757875
124regulation of translation in response to stress (GO:0043555)2.63465103
125chaperone mediated protein folding requiring cofactor (GO:0051085)2.63331686
126NADPH regeneration (GO:0006740)2.61349940
127negative regulation of fibroblast apoptotic process (GO:2000270)2.60495167
128osteoclast differentiation (GO:0030316)2.58960507
129regulation of leukocyte degranulation (GO:0043300)2.57333558
130formation of translation preinitiation complex (GO:0001731)2.56069428
131regulation of tolerance induction (GO:0002643)2.52052965
132regulation of posttranscriptional gene silencing (GO:0060147)2.51976052
133regulation of gene silencing by miRNA (GO:0060964)2.51976052
134regulation of gene silencing by RNA (GO:0060966)2.51976052
135regulation of histone H3-K9 methylation (GO:0051570)2.51853629
136regulation of myeloid leukocyte mediated immunity (GO:0002886)2.51008066
137positive regulation of macrophage differentiation (GO:0045651)2.50712830
138protein localization to kinetochore (GO:0034501)2.48068496
139protein localization to chromosome, centromeric region (GO:0071459)2.47232205
140regulation of telomere maintenance via telomerase (GO:0032210)2.46811433
141determination of adult lifespan (GO:0008340)2.45608924
142histone H3-K36 demethylation (GO:0070544)2.43679007
143regulation of sister chromatid cohesion (GO:0007063)2.42004668
144pre-miRNA processing (GO:0031054)2.41236313
145histone mRNA catabolic process (GO:0071044)2.39777367
146cell adhesion mediated by integrin (GO:0033627)2.38489857
147pentose-phosphate shunt (GO:0006098)2.36895875
148imidazole-containing compound metabolic process (GO:0052803)2.35158897
149membrane raft organization (GO:0031579)2.33920421
150membrane protein ectodomain proteolysis (GO:0006509)2.31142704
151response to X-ray (GO:0010165)2.30519668
152positive regulation of regulated secretory pathway (GO:1903307)2.30413444
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.29634340
154establishment of viral latency (GO:0019043)2.29588941
155mRNA transcription (GO:0009299)2.24399579
156regulation of fibroblast apoptotic process (GO:2000269)2.23907060
157mRNA transcription from RNA polymerase II promoter (GO:0042789)2.23524423
158COPII vesicle coating (GO:0048208)2.22841991
159cell wall macromolecule catabolic process (GO:0016998)2.21859005
160cytokine secretion (GO:0050663)2.21836250
161positive regulation of histone H3-K4 methylation (GO:0051571)2.16847866
162protein retention in ER lumen (GO:0006621)2.14999135
163phagocytosis, engulfment (GO:0006911)2.14383246
164positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.14248276
165positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.14248276
166positive regulation of mitotic sister chromatid separation (GO:1901970)2.14248276
167protein localization to endosome (GO:0036010)2.13779747
168B cell activation involved in immune response (GO:0002312)2.13573975
169regulation of DNA damage checkpoint (GO:2000001)2.13482520
170antigen processing and presentation via MHC class Ib (GO:0002475)2.13290652
171nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.12750983
172somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.12210036
173isotype switching (GO:0045190)2.12210036
174somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.12210036
175germ cell migration (GO:0008354)2.12197291
176ER overload response (GO:0006983)2.09699032
177mitochondrial DNA replication (GO:0006264)2.08519565
178necroptotic process (GO:0070266)2.08189459
179T cell apoptotic process (GO:0070231)2.07204232
180somatic recombination of immunoglobulin gene segments (GO:0016447)2.06617665
181positive regulation of bone resorption (GO:0045780)2.05563922
182positive regulation of bone remodeling (GO:0046852)2.05563922
183Rap protein signal transduction (GO:0032486)2.05553527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.84975050
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.53567516
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.42503507
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.31547175
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.21072214
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.16881953
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.97044402
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.71777465
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67481725
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29616798
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13567430
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05766870
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.91843977
14SCL_19346495_ChIP-Seq_HPC-7_Human2.89856773
15RUNX_20019798_ChIP-Seq_JUKART_Human2.69019475
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66566289
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66114488
18GATA1_22025678_ChIP-Seq_K562_Human2.59966396
19E2F7_22180533_ChIP-Seq_HELA_Human2.54652846
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33983044
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30572748
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27566184
23SPI1_23127762_ChIP-Seq_K562_Human2.19593252
24SPI1_23547873_ChIP-Seq_NB4_Human2.16222282
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12484282
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09948807
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05722180
28MYB_26560356_Chip-Seq_TH2_Human2.04823853
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01181439
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99879517
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95319754
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.94649174
33MYB_26560356_Chip-Seq_TH1_Human1.93397057
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92400759
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.90429890
36PU_27001747_Chip-Seq_BMDM_Mouse1.88400609
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.87952161
38VDR_24787735_ChIP-Seq_THP-1_Human1.85551068
39* TFEB_21752829_ChIP-Seq_HELA_Human1.84402491
40VDR_24763502_ChIP-Seq_THP-1_Human1.82278392
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71543786
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.70201261
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68784147
44VDR_21846776_ChIP-Seq_THP-1_Human1.63891564
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62940412
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59525575
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56777359
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50747324
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49914929
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49723923
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49055639
52ELK1_19687146_ChIP-ChIP_HELA_Human1.48712020
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45420587
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45294754
55MAF_26560356_Chip-Seq_TH1_Human1.44308411
56GATA3_27048872_Chip-Seq_THYMUS_Human1.43598189
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.42456181
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42397588
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38958800
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37503544
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.36398481
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35469103
63MYC_22102868_ChIP-Seq_BL_Human1.33820817
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33324013
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32941499
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32317781
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30997578
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30585284
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30484375
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30326833
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29348186
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.28011406
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27781644
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.26924165
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26083464
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25223972
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25125943
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23775905
79AR_21909140_ChIP-Seq_LNCAP_Human1.21769101
80GATA3_26560356_Chip-Seq_TH2_Human1.21461248
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19514252
82* MYC_18555785_ChIP-Seq_MESCs_Mouse1.18469051
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17936582
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16083213
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.15076888
86BRD4_25478319_ChIP-Seq_HGPS_Human1.13705563
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13322896
88FOXP3_21729870_ChIP-Seq_TREG_Human1.13024803
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12636511
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12636511
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12500753
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12473806
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12118968
94UTX_26944678_Chip-Seq_JUKART_Human1.11758645
95TCF7_22412390_ChIP-Seq_EML_Mouse1.09992697
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06810990
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05677805
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04857314
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04804440
100CLOCK_20551151_ChIP-Seq_293T_Human1.03713638
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03625698
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03484045
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02937570
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02718099
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02406007
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99747449
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.98444796
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.97940734
109* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96328494
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96184547
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95361045
112TP53_16413492_ChIP-PET_HCT116_Human0.94545550
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94394665
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94090852
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.93800248
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.93303012
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92470399
118MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91479778
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90820212
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87811730
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87764029
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87274116
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87085018
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86324956
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84195152
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84059720
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82881923
128GATA2_19941826_ChIP-Seq_K562_Human0.82854224
129* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82842044
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82784864
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82513084
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82361221
133* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81477032
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81055403
135VDR_23849224_ChIP-Seq_CD4+_Human0.80902969
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80137204
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80134336
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78593683
139PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78182994
140SMRT_27268052_Chip-Seq_Bcells_Human0.77482603
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76231040
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75961893
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.74679073
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.73718594
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72453706
146HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72449915
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.72329587
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71751684
149PU1_27457419_Chip-Seq_LIVER_Mouse0.70463716
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.70445849
151GBX2_23144817_ChIP-Seq_PC3_Human0.68610748
152CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67806939
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67787710
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67750891
155RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66867646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.01041405
2MP0008057_abnormal_DNA_replication3.68193654
3MP0000569_abnormal_digit_pigmentation3.59885246
4MP0002877_abnormal_melanocyte_morpholog3.45261849
5MP0006054_spinal_hemorrhage3.23233385
6MP0001800_abnormal_humoral_immune3.08138389
7MP0005671_abnormal_response_to3.05217205
8MP0003436_decreased_susceptibility_to2.97993737
9MP0002452_abnormal_antigen_presenting2.92501782
10MP0002419_abnormal_innate_immunity2.85430518
11MP0005000_abnormal_immune_tolerance2.85185084
12MP0005387_immune_system_phenotype2.81863041
13MP0001790_abnormal_immune_system2.81863041
14MP0004264_abnormal_extraembryonic_tissu2.63720034
15MP0002723_abnormal_immune_serum2.61210103
16MP0003172_abnormal_lysosome_physiology2.59337894
17MP0002254_reproductive_system_inflammat2.59094925
18MP0001819_abnormal_immune_cell2.53831897
19MP0002148_abnormal_hypersensitivity_rea2.53653441
20MP0002420_abnormal_adaptive_immunity2.51925161
21MP0003191_abnormal_cellular_cholesterol2.49653413
22MP0000372_irregular_coat_pigmentation2.43242846
23MP0000685_abnormal_immune_system2.43026421
24MP0006082_CNS_inflammation2.37893259
25MP0005025_abnormal_response_to2.37363000
26MP0003303_peritoneal_inflammation2.35651153
27MP0002396_abnormal_hematopoietic_system2.28518043
28* MP0005464_abnormal_platelet_physiology2.23319368
29MP0005174_abnormal_tail_pigmentation2.22256689
30MP0009785_altered_susceptibility_to2.21870219
31MP0005058_abnormal_lysosome_morphology2.15182597
32MP0003763_abnormal_thymus_physiology2.06381312
33MP0000015_abnormal_ear_pigmentation2.04590657
34* MP0002398_abnormal_bone_marrow2.00238244
35MP0010094_abnormal_chromosome_stability1.94543460
36MP0004381_abnormal_hair_follicle1.91436747
37MP0000716_abnormal_immune_system1.91181208
38MP0003724_increased_susceptibility_to1.89893856
39MP0002009_preneoplasia1.89483761
40MP0001853_heart_inflammation1.87178920
41MP0000689_abnormal_spleen_morphology1.85184870
42MP0002166_altered_tumor_susceptibility1.80004543
43MP0002405_respiratory_system_inflammati1.79957217
44MP0003300_gastrointestinal_ulcer1.77744129
45MP0010234_abnormal_vibrissa_follicle1.75489343
46MP0003183_abnormal_peptide_metabolism1.72086966
47MP0004957_abnormal_blastocyst_morpholog1.68278519
48MP0001845_abnormal_inflammatory_respons1.65653036
49MP0002006_tumorigenesis1.58278881
50MP0002722_abnormal_immune_system1.56323758
51* MP0002429_abnormal_blood_cell1.54474772
52* MP0000371_diluted_coat_color1.52505788
53MP0003221_abnormal_cardiomyocyte_apopto1.51315311
54MP0009278_abnormal_bone_marrow1.49258424
55MP0008058_abnormal_DNA_repair1.49232536
56MP0003111_abnormal_nucleus_morphology1.47115593
57MP0004510_myositis1.46287866
58MP0009333_abnormal_splenocyte_physiolog1.45741449
59* MP0005075_abnormal_melanosome_morpholog1.44035770
60MP0004808_abnormal_hematopoietic_stem1.40304953
61MP0000465_gastrointestinal_hemorrhage1.40044694
62MP0001533_abnormal_skeleton_physiology1.39706227
63MP0010155_abnormal_intestine_physiology1.36282389
64MP0003077_abnormal_cell_cycle1.35969226
65MP0001915_intracranial_hemorrhage1.35658340
66MP0008007_abnormal_cellular_replicative1.31827533
67MP0005171_absent_coat_pigmentation1.31048531
68MP0004947_skin_inflammation1.29435446
69MP0003828_pulmonary_edema1.26520065
70MP0003045_fibrosis1.24796565
71MP0008469_abnormal_protein_level1.24645245
72MP0002095_abnormal_skin_pigmentation1.22587616
73MP0004233_abnormal_muscle_weight1.21611381
74MP0001545_abnormal_hematopoietic_system1.19727862
75MP0005397_hematopoietic_system_phenotyp1.19727862
76MP0003806_abnormal_nucleotide_metabolis1.19642644
77MP0001873_stomach_inflammation1.19079469
78MP0000703_abnormal_thymus_morphology1.18799458
79MP0002086_abnormal_extraembryonic_tissu1.17995172
80MP0003656_abnormal_erythrocyte_physiolo1.17686056
81MP0009764_decreased_sensitivity_to1.16491279
82MP0005621_abnormal_cell_physiology1.14050124
83MP0003984_embryonic_growth_retardation1.13330601
84MP0002088_abnormal_embryonic_growth/wei1.13091502
85MP0005310_abnormal_salivary_gland1.12629656
86MP0005408_hypopigmentation1.12179508
87MP0001672_abnormal_embryogenesis/_devel1.11345564
88MP0005380_embryogenesis_phenotype1.11345564
89MP0004272_abnormal_basement_membrane1.11075497
90MP0001730_embryonic_growth_arrest1.10796989
91MP0009384_cardiac_valve_regurgitation1.10130968
92MP0009697_abnormal_copulation1.07187344
93MP0002277_abnormal_respiratory_mucosa1.06539115
94MP0004185_abnormal_adipocyte_glucose1.05609083
95MP0002933_joint_inflammation1.05326218
96MP0002998_abnormal_bone_remodeling1.04692700
97MP0001986_abnormal_taste_sensitivity1.03057754
98MP0000343_altered_response_to1.00649259
99MP0010307_abnormal_tumor_latency1.00190430
100MP0002019_abnormal_tumor_incidence0.98604152
101MP0000350_abnormal_cell_proliferation0.98451059
102MP0001697_abnormal_embryo_size0.97669572
103MP0003890_abnormal_embryonic-extraembry0.96165084
104MP0002928_abnormal_bile_duct0.96027343
105MP0005384_cellular_phenotype0.94523368
106MP0009672_abnormal_birth_weight0.93205357
107MP0010678_abnormal_skin_adnexa0.92780391
108MP0001851_eye_inflammation0.91842737
109MP0002080_prenatal_lethality0.89557144
110MP0003693_abnormal_embryo_hatching0.89471978
111MP0000490_abnormal_crypts_of0.88726399
112MP0003075_altered_response_to0.87787549
113MP0003448_altered_tumor_morphology0.86115376
114MP0004197_abnormal_fetal_growth/weight/0.85256667
115MP0000598_abnormal_liver_morphology0.84971157
116MP0010352_gastrointestinal_tract_polyps0.81244640
117MP0005257_abnormal_intraocular_pressure0.80986215
118MP0002090_abnormal_vision0.80794929
119MP0008932_abnormal_embryonic_tissue0.80569790
120MP0005451_abnormal_body_composition0.79899271
121* MP0002075_abnormal_coat/hair_pigmentati0.79697070
122MP0004147_increased_porphyrin_level0.79038953
123MP0004484_altered_response_of0.77677550
124MP0003866_abnormal_defecation0.71988566
125* MP0001186_pigmentation_phenotype0.70302781
126MP0002136_abnormal_kidney_physiology0.69326164
127MP0005166_decreased_susceptibility_to0.66336556
128MP0003690_abnormal_glial_cell0.66238653
129MP0002138_abnormal_hepatobiliary_system0.65914485
130MP0003091_abnormal_cell_migration0.65860306
131MP0000858_altered_metastatic_potential0.65763848
132MP0005076_abnormal_cell_differentiation0.65149139
133MP0009763_increased_sensitivity_to0.64968758
134MP0000920_abnormal_myelination0.63160001
135MP0004782_abnormal_surfactant_physiolog0.62733429
136MP0000249_abnormal_blood_vessel0.62573984
137MP0000767_abnormal_smooth_muscle0.61754440
138MP0005390_skeleton_phenotype0.61188925
139MP0003566_abnormal_cell_adhesion0.60337787
140MP0003795_abnormal_bone_structure0.56961459
141MP0008260_abnormal_autophagy0.55016096
142MP0003943_abnormal_hepatobiliary_system0.53941829

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.72553072
2Recurrent bacterial skin infections (HP:0005406)5.19440945
3Eczematoid dermatitis (HP:0000976)5.07039290
4Mediastinal lymphadenopathy (HP:0100721)4.38204124
5IgM deficiency (HP:0002850)3.85596214
6Papillary thyroid carcinoma (HP:0002895)3.75709047
7Systemic lupus erythematosus (HP:0002725)3.71270613
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.69584303
9Recurrent fungal infections (HP:0002841)3.65816755
10Myositis (HP:0100614)3.64750157
11Autoimmune thrombocytopenia (HP:0001973)3.63828604
12Recurrent gram-negative bacterial infections (HP:0005420)3.61910891
13Increased cerebral lipofuscin (HP:0011813)3.61460246
14Meningitis (HP:0001287)3.57146453
15Prostate neoplasm (HP:0100787)3.56106458
16Chronic obstructive pulmonary disease (HP:0006510)3.52399687
17Obstructive lung disease (HP:0006536)3.52399687
18Recurrent viral infections (HP:0004429)3.50835358
19Recurrent skin infections (HP:0001581)3.43665602
20Vasculitis (HP:0002633)3.39816765
21Elevated erythrocyte sedimentation rate (HP:0003565)3.35290876
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.34751007
23Recurrent cutaneous fungal infections (HP:0011370)3.20664738
24Chronic mucocutaneous candidiasis (HP:0002728)3.20664738
25Agammaglobulinemia (HP:0004432)3.16565570
26Abnormality of glycolipid metabolism (HP:0010969)3.13805186
27Abnormality of liposaccharide metabolism (HP:0010968)3.13805186
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.13805186
29Abnormality of the fingertips (HP:0001211)3.07858423
30Optic neuritis (HP:0100653)3.07066770
31Retrobulbar optic neuritis (HP:0100654)3.07066770
32Abnormality of macrophages (HP:0004311)3.06761775
33Hematochezia (HP:0002573)3.01779647
34Gingivitis (HP:0000230)3.01579889
35Abnormality of the prostate (HP:0008775)2.96951557
36Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.94081583
37Colitis (HP:0002583)2.91870887
38Orchitis (HP:0100796)2.85393368
39Glomerulonephritis (HP:0000099)2.84681482
40Spastic diplegia (HP:0001264)2.84259095
41Cellulitis (HP:0100658)2.83271176
42Chronic diarrhea (HP:0002028)2.82183989
43Inflammation of the large intestine (HP:0002037)2.80626888
44Periodontitis (HP:0000704)2.74189010
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.73616954
46IgA deficiency (HP:0002720)2.71640624
47Osteomyelitis (HP:0002754)2.71318957
48Scanning speech (HP:0002168)2.70373153
49Myocardial infarction (HP:0001658)2.69062191
50Gastrointestinal inflammation (HP:0004386)2.63037810
51Thyroid carcinoma (HP:0002890)2.62686444
52Pulmonary infiltrates (HP:0002113)2.61435803
53Panhypogammaglobulinemia (HP:0003139)2.59911444
54Thick nail (HP:0001805)2.57900326
55Spondylolisthesis (HP:0003302)2.57372896
56Syringomyelia (HP:0003396)2.57023433
57Spinal cord lesions (HP:0100561)2.57023433
58Recurrent pneumonia (HP:0006532)2.54576227
59Lymphopenia (HP:0001888)2.52861713
60Pustule (HP:0200039)2.49927771
61Vertebral compression fractures (HP:0002953)2.49883168
62Freckling (HP:0001480)2.48889481
63Thickened calvaria (HP:0002684)2.46675315
64Hemoptysis (HP:0002105)2.46032360
65Subacute progressive viral hepatitis (HP:0006572)2.45361155
66Curly hair (HP:0002212)2.43666576
67Vacuolated lymphocytes (HP:0001922)2.42809656
68Viral hepatitis (HP:0006562)2.42493950
69Loss of speech (HP:0002371)2.40882957
70Arterial thrombosis (HP:0004420)2.38978988
71Gastrointestinal stroma tumor (HP:0100723)2.38500184
72Abnormality of the frontal sinuses (HP:0002687)2.36725277
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.36521363
74Upper motor neuron abnormality (HP:0002127)2.35535613
75Lymphoma (HP:0002665)2.34461700
76Agnosia (HP:0010524)2.32297170
77Stomatitis (HP:0010280)2.32002657
78Nephritis (HP:0000123)2.29736513
79Recurrent bronchitis (HP:0002837)2.27697620
80Recurrent lower respiratory tract infections (HP:0002783)2.26394041
81T lymphocytopenia (HP:0005403)2.25641237
82Chronic otitis media (HP:0000389)2.25471821
83Eosinophilia (HP:0001880)2.25103576
84Delayed closure of the anterior fontanelle (HP:0001476)2.25013048
85Dysostosis multiplex (HP:0000943)2.22280704
86Bilateral sensorineural hearing impairment (HP:0008619)2.21188854
87Urethral obstruction (HP:0000796)2.20811823
88Intrahepatic cholestasis (HP:0001406)2.19932610
89Cutaneous melanoma (HP:0012056)2.19315710
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.19189819
91Prolonged bleeding time (HP:0003010)2.18818600
92Abnormality of T cell number (HP:0011839)2.18608003
93Spontaneous hematomas (HP:0007420)2.18383591
94Failure to thrive in infancy (HP:0001531)2.18367894
95Abnormality of the pleura (HP:0002103)2.17453039
96Restrictive lung disease (HP:0002091)2.16644616
97Fatigue (HP:0012378)2.13956740
98Amaurosis fugax (HP:0100576)2.11657106
99Leukopenia (HP:0001882)2.11640764
100IgG deficiency (HP:0004315)2.11146601
101Interstitial pulmonary disease (HP:0006530)2.10226061
102Thoracic kyphosis (HP:0002942)2.09716419
103Acute myeloid leukemia (HP:0004808)2.09563488
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08262203
105Transitional cell carcinoma of the bladder (HP:0006740)2.08139144
106Asymmetry of the thorax (HP:0001555)2.08010890
107Basal ganglia calcification (HP:0002135)2.07797835
108Recurrent sinusitis (HP:0011108)2.06166701
109Conjunctival telangiectasia (HP:0000524)2.05883798
110Urinary glycosaminoglycan excretion (HP:0003541)2.05833595
111Mucopolysacchariduria (HP:0008155)2.05833595
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.04423703
113Osteolytic defects of the hand bones (HP:0009699)2.04423703
114Keratoconjunctivitis sicca (HP:0001097)2.03549687
115Abnormality of T cells (HP:0002843)2.03527035
116Abnormality of the lumbar spine (HP:0100712)2.03176608
117Gastrointestinal carcinoma (HP:0002672)2.02475750
118Malignant gastrointestinal tract tumors (HP:0006749)2.02475750
119Abnormal spermatogenesis (HP:0008669)2.02063708
120Emphysema (HP:0002097)2.01474270
121Encephalitis (HP:0002383)2.00534219
122Progressive visual loss (HP:0000529)1.99804450
123Abnormality of the thoracic spine (HP:0100711)1.99694833
124Menstrual irregularities (HP:0000858)1.99557595
125Leukocytosis (HP:0001974)1.99431535
126Disinhibition (HP:0000734)1.99350449
127Arthropathy (HP:0003040)1.99212951
128Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97756866
129Orthostatic hypotension (HP:0001278)1.97675612
130Deep philtrum (HP:0002002)1.96892439
131Thyroiditis (HP:0100646)1.96842822
132Bladder carcinoma (HP:0002862)1.96657944
133Bladder neoplasm (HP:0009725)1.96657944
134Pulmonary fibrosis (HP:0002206)1.95921966
135Tetraparesis (HP:0002273)1.95212394
136Abnormality of oral frenula (HP:0000190)1.94959757
137Abnormality of polysaccharide metabolism (HP:0011012)1.93817422
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93817422
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93817422
140Chromsome breakage (HP:0040012)1.92435822
141Abnormality of complement system (HP:0005339)1.92316882
142Autoimmune hemolytic anemia (HP:0001890)1.91677432
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90230228
144Absent frontal sinuses (HP:0002688)1.90098102
145Generalized hypopigmentation of hair (HP:0011358)1.89546111
146Azoospermia (HP:0000027)1.89301048
147Micronodular cirrhosis (HP:0001413)1.88981828
148Abnormality of chromosome stability (HP:0003220)1.87288996
149Nephroblastoma (Wilms tumor) (HP:0002667)1.85614320
150Short humerus (HP:0005792)1.85236467
151J-shaped sella turcica (HP:0002680)1.84437666
152Relative macrocephaly (HP:0004482)1.82360081
153Coarse hair (HP:0002208)1.80872642
154Embryonal renal neoplasm (HP:0011794)1.80758832
155Deviation of the thumb (HP:0009603)1.79319477
156Uterine leiomyosarcoma (HP:0002891)1.77563403
157Leiomyosarcoma (HP:0100243)1.77563403
158Esophageal varix (HP:0002040)1.75611526
159Acute lymphatic leukemia (HP:0006721)1.74424719
160Prominent nose (HP:0000448)1.74203934
161Hepatitis (HP:0012115)1.72176786
162Selective tooth agenesis (HP:0001592)1.71863961
163Male infertility (HP:0003251)1.71222210
164Aplasia/hypoplasia of the humerus (HP:0006507)1.69479780
165Vertebral arch anomaly (HP:0008438)1.67749108
166Delayed cranial suture closure (HP:0000270)1.66133473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.67584195
2MAP3K143.51591412
3CLK13.19346791
4TRIM283.09060271
5TGFBR22.84683732
6IRAK42.79013726
7RIPK42.70566119
8EIF2AK12.56595209
9IRAK32.51774897
10TAF12.50279744
11CSF1R2.49766212
12TYK22.49249877
13TBK12.40036350
14SIK32.36666010
15TXK2.36587271
16EEF2K2.24964163
17MAP4K22.16135598
18FES2.13709287
19RPS6KB22.02182121
20KIT2.01987328
21JAK12.01811262
22MARK31.98275173
23BLK1.94019040
24MAP3K61.89201907
25TEC1.74186628
26CSK1.69943617
27ZAP701.68750768
28MAP3K131.65712940
29MAP2K31.65414090
30IKBKE1.65227335
31SYK1.60165750
32BTK1.58701803
33IKBKB1.54074042
34JAK31.50851365
35FLT31.50817172
36TESK21.49231740
37ITK1.43776820
38HCK1.43717156
39TAOK21.36405569
40LCK1.36183612
41PBK1.35715488
42CDK191.33748166
43FGFR31.31672885
44STK101.31311079
45LYN1.30015250
46IRAK11.29974017
47YES11.29144421
48MST41.27721767
49NEK11.27000555
50NEK91.21182998
51GRK71.20862788
52PAK41.17435933
53SMG11.14999963
54ERBB41.11951321
55BRSK21.11326838
56PRKD21.09753698
57TRPM71.09319593
58CHUK1.09233597
59SIK21.09223483
60STK41.07758069
61MATK1.06522399
62PIM11.06365691
63PKN21.03658358
64CAMK1D0.97264911
65NUAK10.96340266
66IRAK20.93828798
67ZAK0.93688370
68ERBB30.85273903
69CDK90.83991619
70TNIK0.82073578
71TSSK60.81114605
72BMPR1B0.79854764
73TAOK30.76326492
74MAP3K80.72991733
75MST1R0.71969963
76CDK120.71814966
77SCYL20.71251029
78MAPK120.71072192
79WEE10.71063344
80MAP3K100.69637693
81MAPK70.68565661
82MKNK20.68289263
83GRK60.67836006
84FGFR10.67455060
85EIF2AK30.67363708
86CDK40.66967591
87ERN10.66734515
88JAK20.66619711
89ACVR1B0.66217521
90TTK0.66117116
91SGK20.65932810
92EIF2AK20.65221193
93BRD40.65194641
94BCR0.65148024
95STK30.65025728
96LATS10.64902541
97BMPR20.63201426
98NEK60.63131841
99STK38L0.62365795
100EGFR0.61288569
101GRK10.60829285
102NLK0.60784537
103MAP3K20.60605204
104KSR10.60218567
105RPS6KA40.57494409
106FGR0.56821191
107PRKCQ0.56657296
108EPHB10.55786005
109MOS0.54744082
110SRPK10.54267366
111RPS6KB10.52610435
112PASK0.51292010
113CAMK1G0.50886682
114INSR0.50280077
115MAP2K20.49583316
116CDK60.48571772
117SGK30.48540474
118ATR0.48161021
119AKT30.46913180
120EPHA30.45851845
121IGF1R0.44867664
122VRK20.44083952
123MAP2K60.43406293
124PLK30.43208487
125MAPK40.42126654
126PRKCD0.41141566
127INSRR0.40985562
128PRPF4B0.38833263
129PDK20.38394222
130PTK60.38123963
131FER0.37808655
132PDGFRB0.37624139
133PDGFRA0.36887363
134MAP3K50.36477257
135ABL10.36221249
136CDC70.35607331
137PDK10.35553933
138MELK0.34732985
139TNK20.33879385
140MAPK150.32867186
141STK240.30679968
142FGFR40.29792950
143MAPKAPK20.29281371

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.64100251
2Staphylococcus aureus infection_Homo sapiens_hsa051502.62369487
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.56819031
4Osteoclast differentiation_Homo sapiens_hsa043802.54324477
5B cell receptor signaling pathway_Homo sapiens_hsa046622.51041367
6Primary immunodeficiency_Homo sapiens_hsa053402.40641076
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33317407
8Hematopoietic cell lineage_Homo sapiens_hsa046402.23914150
9Other glycan degradation_Homo sapiens_hsa005112.18507931
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.15482604
11Measles_Homo sapiens_hsa051622.07947104
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.05296046
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95795347
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90308059
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88757010
16Tuberculosis_Homo sapiens_hsa051521.81531948
17Pentose phosphate pathway_Homo sapiens_hsa000301.79975410
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79055209
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72278093
20Pertussis_Homo sapiens_hsa051331.68483273
21Lysosome_Homo sapiens_hsa041421.62648474
22Graft-versus-host disease_Homo sapiens_hsa053321.61240902
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60789412
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59301434
25Thyroid cancer_Homo sapiens_hsa052161.57279362
26Chemokine signaling pathway_Homo sapiens_hsa040621.55697549
27Toxoplasmosis_Homo sapiens_hsa051451.55463248
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54587914
29Influenza A_Homo sapiens_hsa051641.54480697
30Herpes simplex infection_Homo sapiens_hsa051681.52853744
31Antigen processing and presentation_Homo sapiens_hsa046121.52392517
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49550955
33Allograft rejection_Homo sapiens_hsa053301.47201191
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45419994
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36856645
36TNF signaling pathway_Homo sapiens_hsa046681.36542506
37T cell receptor signaling pathway_Homo sapiens_hsa046601.35796713
38Malaria_Homo sapiens_hsa051441.33249448
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31980983
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.30564079
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.30389310
42Nucleotide excision repair_Homo sapiens_hsa034201.30346750
43mRNA surveillance pathway_Homo sapiens_hsa030151.27572193
44DNA replication_Homo sapiens_hsa030301.25686625
45Hepatitis B_Homo sapiens_hsa051611.23960033
46Legionellosis_Homo sapiens_hsa051341.22282033
47Renin-angiotensin system_Homo sapiens_hsa046141.20979712
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20755279
49Apoptosis_Homo sapiens_hsa042101.19756018
50Phagosome_Homo sapiens_hsa041451.19454018
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18961605
52Cell cycle_Homo sapiens_hsa041101.16651267
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11227391
54Shigellosis_Homo sapiens_hsa051311.11160410
55N-Glycan biosynthesis_Homo sapiens_hsa005101.09798605
56RNA transport_Homo sapiens_hsa030131.07934825
57Rheumatoid arthritis_Homo sapiens_hsa053231.04855667
58Galactose metabolism_Homo sapiens_hsa000521.04287809
59Viral myocarditis_Homo sapiens_hsa054161.03670427
60Hepatitis C_Homo sapiens_hsa051601.02985228
61Salmonella infection_Homo sapiens_hsa051321.02490335
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01620889
63Endometrial cancer_Homo sapiens_hsa052131.00847922
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.00577557
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99004675
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.98562673
67Biosynthesis of amino acids_Homo sapiens_hsa012300.97462526
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.96362517
69Homologous recombination_Homo sapiens_hsa034400.94358155
70Pancreatic cancer_Homo sapiens_hsa052120.93871515
71Platelet activation_Homo sapiens_hsa046110.93387436
72Mismatch repair_Homo sapiens_hsa034300.92813738
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89761756
74Renal cell carcinoma_Homo sapiens_hsa052110.89707511
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.87900091
76Chronic myeloid leukemia_Homo sapiens_hsa052200.87524521
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84545057
78Small cell lung cancer_Homo sapiens_hsa052220.84494024
79Acute myeloid leukemia_Homo sapiens_hsa052210.82443682
80Proteoglycans in cancer_Homo sapiens_hsa052050.81248874
81Epstein-Barr virus infection_Homo sapiens_hsa051690.77905181
82Type I diabetes mellitus_Homo sapiens_hsa049400.77500993
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76877234
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75394366
85Autoimmune thyroid disease_Homo sapiens_hsa053200.75305464
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.75191413
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73728972
88Asthma_Homo sapiens_hsa053100.71588902
89Starch and sucrose metabolism_Homo sapiens_hsa005000.71544537
90Sphingolipid metabolism_Homo sapiens_hsa006000.70676833
91Fanconi anemia pathway_Homo sapiens_hsa034600.70112899
92African trypanosomiasis_Homo sapiens_hsa051430.68865455
93Inositol phosphate metabolism_Homo sapiens_hsa005620.68074042
94ABC transporters_Homo sapiens_hsa020100.67369421
95Carbon metabolism_Homo sapiens_hsa012000.67140192
96Glioma_Homo sapiens_hsa052140.65383292
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65088871
98RNA degradation_Homo sapiens_hsa030180.63732119
99Basal transcription factors_Homo sapiens_hsa030220.62269460
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60336854
101TGF-beta signaling pathway_Homo sapiens_hsa043500.59534725
102Histidine metabolism_Homo sapiens_hsa003400.59528921
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58827151
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57265119
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56448036
106Bladder cancer_Homo sapiens_hsa052190.55015567
107Prolactin signaling pathway_Homo sapiens_hsa049170.54148771
108Lysine degradation_Homo sapiens_hsa003100.51586731
109Caffeine metabolism_Homo sapiens_hsa002320.49445399
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49261604
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48995328
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47381503
113Base excision repair_Homo sapiens_hsa034100.47032402
114Viral carcinogenesis_Homo sapiens_hsa052030.46910907
115Adherens junction_Homo sapiens_hsa045200.46332203
116FoxO signaling pathway_Homo sapiens_hsa040680.45863492
117HTLV-I infection_Homo sapiens_hsa051660.44130876
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44061727
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43336071
120Endocytosis_Homo sapiens_hsa041440.43274184
121p53 signaling pathway_Homo sapiens_hsa041150.43144105
122MAPK signaling pathway_Homo sapiens_hsa040100.42571955
123HIF-1 signaling pathway_Homo sapiens_hsa040660.42088841
124Colorectal cancer_Homo sapiens_hsa052100.41990915
125Non-homologous end-joining_Homo sapiens_hsa034500.41876372
126Prostate cancer_Homo sapiens_hsa052150.41361720
127Complement and coagulation cascades_Homo sapiens_hsa046100.40522317
128MicroRNAs in cancer_Homo sapiens_hsa052060.40150859
129Phototransduction_Homo sapiens_hsa047440.39181067
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39036952
131Fatty acid biosynthesis_Homo sapiens_hsa000610.38144485
132Non-small cell lung cancer_Homo sapiens_hsa052230.37324682
133Type II diabetes mellitus_Homo sapiens_hsa049300.37147511
134Notch signaling pathway_Homo sapiens_hsa043300.36840818
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31554031

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