HP1BP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)6.00507793
2sister chromatid segregation (GO:0000819)5.93378411
3nuclear pore complex assembly (GO:0051292)5.80425603
4mitotic sister chromatid cohesion (GO:0007064)5.64447164
5mitotic sister chromatid segregation (GO:0000070)5.45290152
6mitotic chromosome condensation (GO:0007076)5.19953935
7regulation of mitotic spindle organization (GO:0060236)4.90967005
8nuclear pore organization (GO:0006999)4.76915770
9DNA unwinding involved in DNA replication (GO:0006268)4.56962161
10kinetochore organization (GO:0051383)4.43110077
11regulation of histone H3-K27 methylation (GO:0061085)4.39188414
12locomotory exploration behavior (GO:0035641)4.28269378
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.13511871
14pore complex assembly (GO:0046931)4.10141763
15regulation of RNA export from nucleus (GO:0046831)3.99227159
16negative regulation of cell killing (GO:0031342)3.93294341
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.93294341
18regulation of spindle organization (GO:0090224)3.85758085
19monoubiquitinated protein deubiquitination (GO:0035520)3.83094822
20cytoplasmic mRNA processing body assembly (GO:0033962)3.80991679
21synaptic vesicle maturation (GO:0016188)3.80236715
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51599172
23V(D)J recombination (GO:0033151)3.51444567
24chromosome condensation (GO:0030261)3.44403409
25histone H3-K9 demethylation (GO:0033169)3.43745092
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.43417359
27definitive hemopoiesis (GO:0060216)3.42284715
28establishment of mitotic spindle localization (GO:0040001)3.42033026
29nerve growth factor signaling pathway (GO:0038180)3.39743570
30layer formation in cerebral cortex (GO:0021819)3.38937302
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.38194298
32establishment of spindle localization (GO:0051293)3.34903733
33dosage compensation (GO:0007549)3.33101454
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.31221359
35glucocorticoid receptor signaling pathway (GO:0042921)3.31220890
36histone H3-K4 trimethylation (GO:0080182)3.29417930
37kinetochore assembly (GO:0051382)3.29132981
38mitotic nuclear envelope disassembly (GO:0007077)3.25678550
39membrane disassembly (GO:0030397)3.25586551
40nuclear envelope disassembly (GO:0051081)3.25586551
41regulation of nucleobase-containing compound transport (GO:0032239)3.25350233
42G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23411537
43interkinetic nuclear migration (GO:0022027)3.23037424
44dendritic spine morphogenesis (GO:0060997)3.22196247
45establishment of nucleus localization (GO:0040023)3.21480113
46regulation of synaptic vesicle exocytosis (GO:2000300)3.20444326
47protein localization to chromosome, centromeric region (GO:0071459)3.19339552
48meiotic chromosome segregation (GO:0045132)3.19306788
49establishment of spindle orientation (GO:0051294)3.18414931
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14738061
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14738061
52microtubule depolymerization (GO:0007019)3.14701071
53protein localization to chromosome (GO:0034502)3.11196086
54vocalization behavior (GO:0071625)3.11134029
55protein localization to kinetochore (GO:0034501)3.06454529
56neuron cell-cell adhesion (GO:0007158)3.06229416
57regulation of glutamate receptor signaling pathway (GO:1900449)3.04981663
58regulation of sister chromatid cohesion (GO:0007063)3.03734872
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.02671463
60regulation of DNA endoreduplication (GO:0032875)3.01116653
61positive T cell selection (GO:0043368)2.96737220
62mitotic cytokinesis (GO:0000281)2.95880917
63axonal fasciculation (GO:0007413)2.95216189
64DNA packaging (GO:0006323)2.94780943
65glial cell proliferation (GO:0014009)2.92270583
66cytoskeleton-dependent cytokinesis (GO:0061640)2.92047234
67spermatid nucleus differentiation (GO:0007289)2.91997503
68metaphase plate congression (GO:0051310)2.91194384
69establishment of chromosome localization (GO:0051303)2.91153179
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91145324
71positive regulation of mitotic sister chromatid separation (GO:1901970)2.91145324
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91145324
73positive regulation of Rap GTPase activity (GO:0032854)2.90971483
74positive regulation of gamma-delta T cell activation (GO:0046645)2.90112131
75chromosome segregation (GO:0007059)2.89361530
76regulation of ARF protein signal transduction (GO:0032012)2.88209575
77exploration behavior (GO:0035640)2.87950461
78activation of protein kinase A activity (GO:0034199)2.85938118
79histone H3-K9 methylation (GO:0051567)2.84137353
80DNA ligation (GO:0006266)2.83904226
81histone H3-K9 modification (GO:0061647)2.81828860
82establishment of mitotic spindle orientation (GO:0000132)2.81100289
83DNA duplex unwinding (GO:0032508)2.79383136
84DNA conformation change (GO:0071103)2.78730962
85embryonic camera-type eye morphogenesis (GO:0048596)2.78728580
86regulation of Rap GTPase activity (GO:0032317)2.78642084
87poly(A)+ mRNA export from nucleus (GO:0016973)2.76949200
88positive regulation of cell cycle checkpoint (GO:1901978)2.76942998
89regulation of synapse structural plasticity (GO:0051823)2.76828540
90nuclear envelope organization (GO:0006998)2.76565154
91histone lysine methylation (GO:0034968)2.76232894
92corticosteroid receptor signaling pathway (GO:0031958)2.76115901
93positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76023140
94dendrite morphogenesis (GO:0048813)2.73782620
95neuron recognition (GO:0008038)2.73459398
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73093828
97synaptic vesicle exocytosis (GO:0016079)2.72885890
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72399267
99peptidyl-threonine phosphorylation (GO:0018107)2.71660312
100regulation of synaptic vesicle transport (GO:1902803)2.70695059
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.69568982
102positive regulation of histone deacetylation (GO:0031065)2.69452307
103regulation of ARF GTPase activity (GO:0032312)2.68392455
104protein-DNA complex disassembly (GO:0032986)2.67776246
105nucleosome disassembly (GO:0006337)2.67776246
106negative T cell selection (GO:0043383)2.67329742
107DNA geometric change (GO:0032392)2.66469552
108response to epidermal growth factor (GO:0070849)2.66098843
109peptidyl-lysine dimethylation (GO:0018027)2.63370867
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62647510
111histone lysine demethylation (GO:0070076)2.62587693
112regulation of neuronal synaptic plasticity (GO:0048168)2.62536647
113mast cell activation involved in immune response (GO:0002279)2.60240037
114mast cell degranulation (GO:0043303)2.60240037
115mitotic metaphase plate congression (GO:0007080)2.59030928
116histone H3-K4 methylation (GO:0051568)2.57552718
117peptidyl-threonine modification (GO:0018210)2.56218200
118histone deubiquitination (GO:0016578)2.54209313
119clathrin coat assembly (GO:0048268)2.53786512
120long-term memory (GO:0007616)2.53200773
121stress granule assembly (GO:0034063)2.52968274
122regulation of DNA damage checkpoint (GO:2000001)2.52422714
123positive regulation of granulocyte differentiation (GO:0030854)2.52356339
124negative thymic T cell selection (GO:0045060)2.52178867
125sister chromatid cohesion (GO:0007062)2.50624670
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49840853
127positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.48442491
128T cell selection (GO:0045058)2.48426472
129histone phosphorylation (GO:0016572)2.47536158
130antigen processing and presentation of endogenous antigen (GO:0019883)2.47193882
131mitotic spindle organization (GO:0007052)2.47168050
132mast cell activation (GO:0045576)2.46956851
133positive regulation of neuroblast proliferation (GO:0002052)2.46858121
134centrosome duplication (GO:0051298)2.46683073
135regulation of chromosome segregation (GO:0051983)2.45912253
136neurotransmitter secretion (GO:0007269)2.45709584
137histone demethylation (GO:0016577)2.45355929
138cerebral cortex radially oriented cell migration (GO:0021799)2.44273582
139prepulse inhibition (GO:0060134)2.43673451
140cerebellar Purkinje cell differentiation (GO:0021702)2.43619096
141negative regulation of cell cycle G2/M phase transition (GO:1902750)2.43614765
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42644021
143adenosine receptor signaling pathway (GO:0001973)2.41960915
144negative regulation of erythrocyte differentiation (GO:0045647)2.41874486
145DNA synthesis involved in DNA repair (GO:0000731)2.40509910
146negative regulation of axon extension (GO:0030517)2.39623141
147regulation of centrosome duplication (GO:0010824)2.39135113
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.39034011
149negative regulation of histone methylation (GO:0031061)2.38967372
150postsynaptic membrane organization (GO:0001941)2.38261841
151positive thymic T cell selection (GO:0045059)2.36686986
152protein localization to synapse (GO:0035418)2.36501121
153central nervous system projection neuron axonogenesis (GO:0021952)2.36394771
154regulation of gamma-delta T cell differentiation (GO:0045586)2.35498441
155microtubule anchoring (GO:0034453)2.33794008
156glutamate secretion (GO:0014047)2.33583377
157histone H4-K16 acetylation (GO:0043984)2.33353379
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32954341
159regulation of dendritic spine morphogenesis (GO:0061001)2.31819699
160spindle organization (GO:0007051)2.31748010
161synaptic transmission, glutamatergic (GO:0035249)2.31729650
162spindle checkpoint (GO:0031577)2.31005967
163regulation of histone methylation (GO:0031060)2.30695944
164glutamate receptor signaling pathway (GO:0007215)2.30110512
165regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29510348
166suckling behavior (GO:0001967)2.28699512
167mating behavior (GO:0007617)2.28466825
168negative regulation of axonogenesis (GO:0050771)2.27073843
169neuronal ion channel clustering (GO:0045161)2.27029498
170positive regulation of membrane potential (GO:0045838)2.26557780
171long-term synaptic potentiation (GO:0060291)2.26368094
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.25544623
173potassium ion import (GO:0010107)2.25190779
174mRNA splice site selection (GO:0006376)2.24035529
175peptidyl-tyrosine autophosphorylation (GO:0038083)2.22701982
176sodium ion export (GO:0071436)2.22597198
177nucleus localization (GO:0051647)2.21713755
178cortical actin cytoskeleton organization (GO:0030866)2.21609351
179presynaptic membrane assembly (GO:0097105)2.20083673
180cellular potassium ion homeostasis (GO:0030007)2.17681421
181negative regulation of phagocytosis (GO:0050765)2.17455447
182activated T cell proliferation (GO:0050798)2.16576837
183peptidyl-lysine trimethylation (GO:0018023)2.16171454
184membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.15891412
185retrograde transport, vesicle recycling within Golgi (GO:0000301)2.14913920
186thymic T cell selection (GO:0045061)2.14480245
187vesicle transport along microtubule (GO:0047496)2.13429409
188signal complex assembly (GO:0007172)2.13389701
189regulation of respiratory system process (GO:0044065)2.12825931
190regulation of postsynaptic membrane potential (GO:0060078)2.11076241
191positive regulation of dendrite morphogenesis (GO:0050775)2.10722201
192megakaryocyte development (GO:0035855)2.09751925
193regulation of axon guidance (GO:1902667)2.09737948
194regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.09234430
195regulation of gamma-delta T cell activation (GO:0046643)2.08758763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human8.20144295
2E2F7_22180533_ChIP-Seq_HELA_Human7.35874013
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.49437510
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.42062413
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79051401
6EZH2_22144423_ChIP-Seq_EOC_Human3.58169813
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.17237639
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04852292
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03228340
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82137499
11DROSHA_22980978_ChIP-Seq_HELA_Human2.59344807
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44644790
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44419753
14GATA1_22025678_ChIP-Seq_K562_Human2.40978651
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36145185
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33537563
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33537563
18AR_21909140_ChIP-Seq_LNCAP_Human2.29443564
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.15944983
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15432829
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12652685
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10680753
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08478006
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08135456
25AR_21572438_ChIP-Seq_LNCaP_Human1.99786079
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98046754
27GBX2_23144817_ChIP-Seq_PC3_Human1.89125853
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.89003510
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88053081
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87662144
31* E2F1_21310950_ChIP-Seq_MCF-7_Human1.84737857
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83991406
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83838728
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.82974696
35RUNX_20019798_ChIP-Seq_JUKART_Human1.82916753
36SCL_19346495_ChIP-Seq_HPC-7_Human1.79773813
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.79023784
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78595863
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77094072
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75825378
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.73815632
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73300964
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.67883556
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67168819
45* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.66804191
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64368863
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64273996
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.60927788
49* KDM2B_26808549_Chip-Seq_DND41_Human1.60453206
50* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56611278
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.53702246
52* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51593923
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49680543
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.49303174
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46975850
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44130102
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44090087
58VDR_21846776_ChIP-Seq_THP-1_Human1.42854286
59* TCF7_22412390_ChIP-Seq_EML_Mouse1.42721260
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41710469
61FUS_26573619_Chip-Seq_HEK293_Human1.41480710
62REST_21632747_ChIP-Seq_MESCs_Mouse1.39873313
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.38822429
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38346522
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37173605
66SOX9_26525672_Chip-Seq_HEART_Mouse1.36981369
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36614341
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34839310
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32457023
70* KDM2B_26808549_Chip-Seq_K562_Human1.31994718
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31734230
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30422172
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29338047
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28853337
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28574994
76CIITA_25753668_ChIP-Seq_RAJI_Human1.28452301
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28441136
78VDR_24763502_ChIP-Seq_THP-1_Human1.27823007
79* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27017033
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24798470
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24562578
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24551652
83SPI1_23127762_ChIP-Seq_K562_Human1.23245755
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.22960559
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22165110
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19926416
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19728854
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18692557
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18352249
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.17678464
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16246151
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15021703
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14917921
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.14771856
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14303862
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12965956
97CLOCK_20551151_ChIP-Seq_293T_Human1.12529788
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12292759
99BRD4_25478319_ChIP-Seq_HGPS_Human1.12191102
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11060384
101* MYC_22102868_ChIP-Seq_BL_Human1.10004235
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09660173
103UTX_26944678_Chip-Seq_JUKART_Human1.09490428
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08776240
105TP53_16413492_ChIP-PET_HCT116_Human1.08618774
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08082490
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07147634
108SMAD4_21799915_ChIP-Seq_A2780_Human1.07087651
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05703474
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04804573
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.04551822
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03788925
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02361447
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02170654
115AR_19668381_ChIP-Seq_PC3_Human1.01610822
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01549646
117TAF15_26573619_Chip-Seq_HEK293_Human1.00293604
118* CHD1_26751641_Chip-Seq_LNCaP_Human1.00118356
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.99656204
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.99285789
121* MAF_26560356_Chip-Seq_TH1_Human0.99030801
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98799529
123GATA1_19941826_ChIP-Seq_K562_Human0.97908553
124AHR_22903824_ChIP-Seq_MCF-7_Human0.97753067
125* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97273599
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95116691
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94826531
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94820583
129* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94125360
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94082799
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.93632668
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93012084
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91885811
134MYB_26560356_Chip-Seq_TH2_Human0.91059584
135VDR_24787735_ChIP-Seq_THP-1_Human0.90656020
136STAT3_23295773_ChIP-Seq_U87_Human0.90525275
137EWS_26573619_Chip-Seq_HEK293_Human0.89344525
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89181421
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.88019408
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86527521
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86501007
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86412458
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84222167
144* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83533248
145MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83409821
146MYB_26560356_Chip-Seq_TH1_Human0.83234361
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82908842
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.80155306
149ISL1_27105846_Chip-Seq_CPCs_Mouse0.79386743
150GATA2_19941826_ChIP-Seq_K562_Human0.77867044
151NCOR1_26117541_ChIP-Seq_K562_Human0.77622207
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.77330050
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.75853204
154NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75782383
155KDM5A_27292631_Chip-Seq_BREAST_Human0.75618412
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74597855
157* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74297650
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74224672
159PADI4_21655091_ChIP-ChIP_MCF-7_Human0.72952457
160TCF4_23295773_ChIP-Seq_U87_Human0.72268655
161* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72123970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90709936
2MP0002009_preneoplasia4.02723077
3MP0008057_abnormal_DNA_replication3.67801426
4MP0000569_abnormal_digit_pigmentation3.57338770
5MP0003880_abnormal_central_pattern3.27030395
6MP0003635_abnormal_synaptic_transmissio3.01604879
7MP0003787_abnormal_imprinting2.85184344
8MP0010094_abnormal_chromosome_stability2.66891332
9MP0003111_abnormal_nucleus_morphology2.65212305
10MP0003705_abnormal_hypodermis_morpholog2.52551619
11MP0005409_darkened_coat_color2.42304150
12MP0005423_abnormal_somatic_nervous2.38408326
13MP0008438_abnormal_cutaneous_collagen2.32677124
14MP0005076_abnormal_cell_differentiation2.30357985
15MP0002063_abnormal_learning/memory/cond2.28928728
16MP0003303_peritoneal_inflammation2.21477260
17MP0003077_abnormal_cell_cycle2.15554395
18MP0003300_gastrointestinal_ulcer2.13189276
19MP0009745_abnormal_behavioral_response2.13110796
20MP0009780_abnormal_chondrocyte_physiolo2.09265394
21MP0002064_seizures2.05813650
22MP0002909_abnormal_adrenal_gland2.01201139
23MP0008961_abnormal_basal_metabolism1.97785217
24MP0000566_synostosis1.95879629
25MP0001486_abnormal_startle_reflex1.89618922
26MP0008569_lethality_at_weaning1.86073072
27MP0000428_abnormal_craniofacial_morphol1.82535385
28MP0000778_abnormal_nervous_system1.74028661
29MP0003122_maternal_imprinting1.73838635
30MP0004270_analgesia1.73775371
31MP0010352_gastrointestinal_tract_polyps1.71042832
32MP0002572_abnormal_emotion/affect_behav1.67512277
33MP0003172_abnormal_lysosome_physiology1.63192287
34MP0004811_abnormal_neuron_physiology1.58920859
35MP0002877_abnormal_melanocyte_morpholog1.58410761
36MP0000920_abnormal_myelination1.57417926
37MP0005171_absent_coat_pigmentation1.53798973
38MP0003935_abnormal_craniofacial_develop1.52879351
39MP0000465_gastrointestinal_hemorrhage1.52411824
40MP0005174_abnormal_tail_pigmentation1.50901930
41MP0005503_abnormal_tendon_morphology1.49819802
42MP0002272_abnormal_nervous_system1.49442328
43MP0002396_abnormal_hematopoietic_system1.48447203
44MP0001968_abnormal_touch/_nociception1.47867331
45MP0003763_abnormal_thymus_physiology1.46180418
46MP0010307_abnormal_tumor_latency1.46099970
47MP0002166_altered_tumor_susceptibility1.44679760
48MP0005275_abnormal_skin_tensile1.44323284
49MP0004808_abnormal_hematopoietic_stem1.41414980
50MP0008007_abnormal_cellular_replicative1.40789540
51MP0000350_abnormal_cell_proliferation1.40635166
52MP0002557_abnormal_social/conspecific_i1.35839985
53MP0005645_abnormal_hypothalamus_physiol1.35467484
54MP0003656_abnormal_erythrocyte_physiolo1.32397139
55MP0003115_abnormal_respiratory_system1.30781807
56MP0001177_atelectasis1.29193376
57MP0003121_genomic_imprinting1.28772936
58MP0003984_embryonic_growth_retardation1.28554688
59MP0003045_fibrosis1.28223889
60MP0004197_abnormal_fetal_growth/weight/1.26986131
61MP0005380_embryogenesis_phenotype1.26369542
62MP0001672_abnormal_embryogenesis/_devel1.26369542
63MP0002088_abnormal_embryonic_growth/wei1.25697397
64MP0004885_abnormal_endolymph1.25439910
65MP0002184_abnormal_innervation1.25087265
66MP0002084_abnormal_developmental_patter1.24752797
67MP0003755_abnormal_palate_morphology1.24115225
68MP0001697_abnormal_embryo_size1.24010035
69MP0003890_abnormal_embryonic-extraembry1.21446938
70MP0001502_abnormal_circadian_rhythm1.21356156
71MP0005646_abnormal_pituitary_gland1.21036275
72MP0000534_abnormal_ureter_morphology1.19640860
73MP0009278_abnormal_bone_marrow1.18599508
74MP0000955_abnormal_spinal_cord1.18435247
75MP0000703_abnormal_thymus_morphology1.18396530
76MP0003861_abnormal_nervous_system1.16965846
77MP0009703_decreased_birth_body1.15193605
78MP0003091_abnormal_cell_migration1.14875935
79MP0002067_abnormal_sensory_capabilities1.13143558
80MP0002086_abnormal_extraembryonic_tissu1.13137097
81MP0004957_abnormal_blastocyst_morpholog1.12995415
82MP0008932_abnormal_embryonic_tissue1.12649204
83MP0009046_muscle_twitch1.12645681
84MP0001970_abnormal_pain_threshold1.12628348
85MP0002882_abnormal_neuron_morphology1.12626826
86MP0002085_abnormal_embryonic_tissue1.12196167
87MP0002249_abnormal_larynx_morphology1.11474926
88MP0009697_abnormal_copulation1.11471025
89MP0002092_abnormal_eye_morphology1.11115764
90MP0000432_abnormal_head_morphology1.10346883
91MP0002822_catalepsy1.10249255
92MP0002734_abnormal_mechanical_nocicepti1.10160869
93MP0000631_abnormal_neuroendocrine_gland1.09569432
94MP0001730_embryonic_growth_arrest1.09281106
95MP0004185_abnormal_adipocyte_glucose1.09029407
96MP0003937_abnormal_limbs/digits/tail_de1.07633723
97MP0005386_behavior/neurological_phenoty1.05845221
98MP0004924_abnormal_behavior1.05845221
99MP0003183_abnormal_peptide_metabolism1.05558558
100MP0001984_abnormal_olfaction1.05551371
101MP0001286_abnormal_eye_development1.02804121
102MP0002733_abnormal_thermal_nociception1.01856009
103MP0002234_abnormal_pharynx_morphology1.00907193
104MP0002114_abnormal_axial_skeleton1.00398689
105MP0002080_prenatal_lethality0.99504881
106MP0003690_abnormal_glial_cell0.98677558
107MP0001188_hyperpigmentation0.98552963
108MP0003938_abnormal_ear_development0.98441370
109MP0002095_abnormal_skin_pigmentation0.98069294
110MP0004147_increased_porphyrin_level0.97833602
111MP0002081_perinatal_lethality0.95225313
112MP0003633_abnormal_nervous_system0.94160693
113MP0002006_tumorigenesis0.94062386
114MP0002925_abnormal_cardiovascular_devel0.93239646
115MP0005464_abnormal_platelet_physiology0.92802837
116MP0002116_abnormal_craniofacial_bone0.91565785
117MP0002066_abnormal_motor_capabilities/c0.90979259
118MP0001958_emphysema0.90901169
119MP0002638_abnormal_pupillary_reflex0.88813155
120MP0003693_abnormal_embryo_hatching0.88325946
121MP0003942_abnormal_urinary_system0.88307254
122MP0002152_abnormal_brain_morphology0.88143377
123MP0000462_abnormal_digestive_system0.87821131
124MP0002398_abnormal_bone_marrow0.86456362
125MP0003221_abnormal_cardiomyocyte_apopto0.86388572
126MP0002089_abnormal_postnatal_growth/wei0.86306173
127MP0005248_abnormal_Harderian_gland0.86275301
128MP0002928_abnormal_bile_duct0.85558028
129MP0005621_abnormal_cell_physiology0.85497101
130MP0001501_abnormal_sleep_pattern0.85193929
131MP0005671_abnormal_response_to0.84837564
132MP0005666_abnormal_adipose_tissue0.83719601
133MP0006276_abnormal_autonomic_nervous0.83020991
134MP0002697_abnormal_eye_size0.82962838
135MP0003943_abnormal_hepatobiliary_system0.82950535
136MP0003634_abnormal_glial_cell0.82579552
137MP0002735_abnormal_chemical_nociception0.82350632
138MP0001879_abnormal_lymphatic_vessel0.82219345
139MP0002177_abnormal_outer_ear0.81827650
140MP0004742_abnormal_vestibular_system0.81645185
141MP0008995_early_reproductive_senescence0.81301970
142MP0002970_abnormal_white_adipose0.81247675
143MP0001545_abnormal_hematopoietic_system0.81168783
144MP0005397_hematopoietic_system_phenotyp0.81168783
145MP0001346_abnormal_lacrimal_gland0.80861227
146MP0002736_abnormal_nociception_after0.80829533
147MP0002108_abnormal_muscle_morphology0.79984334
148MP0003866_abnormal_defecation0.79931813
149MP0000427_abnormal_hair_cycle0.79685304
150MP0002233_abnormal_nose_morphology0.79462470
151MP0001299_abnormal_eye_distance/0.78825690
152MP0002420_abnormal_adaptive_immunity0.78739839
153MP0006138_congestive_heart_failure0.78619372
154MP0003385_abnormal_body_wall0.78081223
155MP0008058_abnormal_DNA_repair0.77956860
156MP0000015_abnormal_ear_pigmentation0.77669898
157MP0009115_abnormal_fat_cell0.77354027
158MP0001270_distended_abdomen0.77002423
159MP0001819_abnormal_immune_cell0.76667676
160MP0000537_abnormal_urethra_morphology0.76435984
161MP0005187_abnormal_penis_morphology0.76133601
162MP0001943_abnormal_respiration0.74503994
163MP0000003_abnormal_adipose_tissue0.74161129
164MP0003950_abnormal_plasma_membrane0.73451864
165MP0002069_abnormal_eating/drinking_beha0.73007847
166MP0003329_amyloid_beta_deposits0.72978215
167MP0005551_abnormal_eye_electrophysiolog0.71080020
168MP0003283_abnormal_digestive_organ0.71049225
169MP0004858_abnormal_nervous_system0.71041428
170MP0008874_decreased_physiological_sensi0.70373613
171MP0000733_abnormal_muscle_development0.70323940
172MP0003075_altered_response_to0.70314144
173MP0000716_abnormal_immune_system0.69724112
174MP0004134_abnormal_chest_morphology0.69299766

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)3.97228189
2Hyperacusis (HP:0010780)3.44765228
3Heterotopia (HP:0002282)3.33512877
4Chronic otitis media (HP:0000389)3.27322955
5Cortical dysplasia (HP:0002539)3.15411551
6Abnormality of the fingertips (HP:0001211)3.09088990
7Macroorchidism (HP:0000053)2.97531054
8Overriding aorta (HP:0002623)2.89852745
9Myokymia (HP:0002411)2.86530694
10Broad-based gait (HP:0002136)2.76642833
11Acute lymphatic leukemia (HP:0006721)2.74923732
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.73361997
13Overlapping toe (HP:0001845)2.70513327
14Pointed chin (HP:0000307)2.69413689
15Abnormality of chromosome segregation (HP:0002916)2.69409019
16Supranuclear gaze palsy (HP:0000605)2.67401690
17Elfin facies (HP:0004428)2.66701785
18Long clavicles (HP:0000890)2.64650082
19Insomnia (HP:0100785)2.64599360
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64536885
21Short 4th metacarpal (HP:0010044)2.64536885
22Volvulus (HP:0002580)2.60877028
23Deep philtrum (HP:0002002)2.57977425
24Focal seizures (HP:0007359)2.56009726
25Visual hallucinations (HP:0002367)2.50735687
26Tented upper lip vermilion (HP:0010804)2.48977613
27Sandal gap (HP:0001852)2.46589081
28Chromsome breakage (HP:0040012)2.46226648
29Broad palm (HP:0001169)2.40973888
30Focal motor seizures (HP:0011153)2.40862968
31Renal duplication (HP:0000075)2.37893608
32Abnormality of oral frenula (HP:0000190)2.36654208
33Narrow palate (HP:0000189)2.32424625
34Acute myeloid leukemia (HP:0004808)2.32307088
35Truncal ataxia (HP:0002078)2.32212425
36Stereotypic behavior (HP:0000733)2.30832905
37Facial hemangioma (HP:0000329)2.28549913
38Obsessive-compulsive behavior (HP:0000722)2.28190181
39Spinal canal stenosis (HP:0003416)2.27628725
40Ankyloglossia (HP:0010296)2.24410166
41Open mouth (HP:0000194)2.23981900
42Renovascular hypertension (HP:0100817)2.23240934
4311 pairs of ribs (HP:0000878)2.21683592
44Depression (HP:0000716)2.19486166
45Broad metatarsal (HP:0001783)2.18129678
46Progressive cerebellar ataxia (HP:0002073)2.15530653
47Relative macrocephaly (HP:0004482)2.14624048
48Large earlobe (HP:0009748)2.14544603
49Truncal obesity (HP:0001956)2.12782628
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11790630
51Inappropriate behavior (HP:0000719)2.11612103
52Missing ribs (HP:0000921)2.11263236
53Urinary urgency (HP:0000012)2.11171343
54Abnormality of the calcaneus (HP:0008364)2.07769736
55Neoplasm of the heart (HP:0100544)2.04265030
56Panhypogammaglobulinemia (HP:0003139)2.03158787
57Absent frontal sinuses (HP:0002688)2.02235867
58Long eyelashes (HP:0000527)2.00926873
59Action tremor (HP:0002345)2.00320684
60Hypoplastic iliac wings (HP:0002866)2.00020560
61Papillary thyroid carcinoma (HP:0002895)1.99697653
62Abnormality of the 4th metacarpal (HP:0010012)1.98825776
63Asymmetry of the thorax (HP:0001555)1.97042219
64Thick eyebrow (HP:0000574)1.96506273
65Recurrent viral infections (HP:0004429)1.96454222
66Arterial tortuosity (HP:0005116)1.95390299
67Spinal cord lesions (HP:0100561)1.93922763
68Syringomyelia (HP:0003396)1.93922763
69Bladder diverticulum (HP:0000015)1.93492197
70Chin dimple (HP:0010751)1.92476494
71Shallow orbits (HP:0000586)1.91877578
72Agammaglobulinemia (HP:0004432)1.91531131
73Ankle clonus (HP:0011448)1.91223621
74Flat cornea (HP:0007720)1.90979836
75Aplasia/Hypoplasia of the sternum (HP:0006714)1.90610351
76T lymphocytopenia (HP:0005403)1.88211604
77Vertebral arch anomaly (HP:0008438)1.87898148
78Cellulitis (HP:0100658)1.87136213
79Cystic hygroma (HP:0000476)1.86517220
80Sacral dimple (HP:0000960)1.86310126
81Cerebral aneurysm (HP:0004944)1.85804667
82Blue irides (HP:0000635)1.83657236
83Menstrual irregularities (HP:0000858)1.83517770
84Tapered finger (HP:0001182)1.82591569
85Scanning speech (HP:0002168)1.81662703
86Spastic gait (HP:0002064)1.81406657
87Cafe-au-lait spot (HP:0000957)1.81300138
88Hemiplegia (HP:0002301)1.81253415
89Thyroiditis (HP:0100646)1.80983337
90Neonatal short-limb short stature (HP:0008921)1.80799914
91Epileptic encephalopathy (HP:0200134)1.80651186
92Low anterior hairline (HP:0000294)1.80604192
93Aortic aneurysm (HP:0004942)1.80005713
94Widely spaced teeth (HP:0000687)1.79308731
95Disproportionate tall stature (HP:0001519)1.79103974
96Exotropia (HP:0000577)1.78737854
97Megalencephaly (HP:0001355)1.78436394
98Bowel diverticulosis (HP:0005222)1.78049594
99Tracheomalacia (HP:0002779)1.77145622
100Genetic anticipation (HP:0003743)1.76994493
101Flared metaphyses (HP:0003015)1.76771371
102Protruding tongue (HP:0010808)1.76099796
103Poor eye contact (HP:0000817)1.75957838
104High anterior hairline (HP:0009890)1.75594112
105Bowel incontinence (HP:0002607)1.73688780
106Dislocated radial head (HP:0003083)1.73439799
107Abnormality of B cell number (HP:0010975)1.73394929
108B lymphocytopenia (HP:0010976)1.73394929
109Agitation (HP:0000713)1.73074792
110Alacrima (HP:0000522)1.73031221
111Impaired vibration sensation in the lower limbs (HP:0002166)1.72792474
112Subaortic stenosis (HP:0001682)1.72766811
113Abnormality of the left ventricular outflow tract (HP:0011103)1.72766811
114Abnormality of the ischium (HP:0003174)1.71627918
115Wide anterior fontanel (HP:0000260)1.71562872
116Papilloma (HP:0012740)1.70399028
117Verrucae (HP:0200043)1.70399028
118Hypopigmentation of the fundus (HP:0007894)1.70051129
119Metaphyseal cupping (HP:0003021)1.69330962
120Vascular tortuosity (HP:0004948)1.69301608
121Intention tremor (HP:0002080)1.69236550
122Smooth philtrum (HP:0000319)1.68838753
123Drooling (HP:0002307)1.67056626
124Excessive salivation (HP:0003781)1.67056626
125Aortic dissection (HP:0002647)1.66154571
126Abnormality of T cell number (HP:0011839)1.65716294
127Abnormal social behavior (HP:0012433)1.65437436
128Impaired social interactions (HP:0000735)1.65437436
129Cutis marmorata (HP:0000965)1.65135393
130Abnormality of the diencephalon (HP:0010662)1.64777501
131Buphthalmos (HP:0000557)1.64511260
132Gastroesophageal reflux (HP:0002020)1.63895755
133Broad ribs (HP:0000885)1.63750556
134Prolonged bleeding time (HP:0003010)1.63407933
135Hypoventilation (HP:0002791)1.62863654
136Attention deficit hyperactivity disorder (HP:0007018)1.62268625
137Abnormality of the radial head (HP:0003995)1.60198537
138Febrile seizures (HP:0002373)1.58825529
139Urinary bladder sphincter dysfunction (HP:0002839)1.58383114
140Trigonocephaly (HP:0000243)1.57963100
141Sporadic (HP:0003745)1.57517552
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.57478636
143Deeply set eye (HP:0000490)1.57467566
144Hepatoblastoma (HP:0002884)1.57429903
145Cubitus valgus (HP:0002967)1.56968969
146Enlarged penis (HP:0000040)1.56905501
147Anxiety (HP:0000739)1.56224818
148Apathy (HP:0000741)1.56049551
149Rhizomelia (HP:0008905)1.55594193
150Hypoplasia of the thymus (HP:0000778)1.55064103
151Limited elbow extension (HP:0001377)1.54901412
152Hamartoma (HP:0010566)1.54887028
153Anteriorly placed anus (HP:0001545)1.54466391
154Abnormality of ocular smooth pursuit (HP:0000617)1.53998199
155Transitional cell carcinoma of the bladder (HP:0006740)1.53781482
156Mild short stature (HP:0003502)1.53742687
157Increased nuchal translucency (HP:0010880)1.53722735
158Hypoplastic ilia (HP:0000946)1.53711497
159Germ cell neoplasia (HP:0100728)1.53470206
160Synophrys (HP:0000664)1.53392475
161Abnormal large intestine physiology (HP:0012700)1.53312110
162Decreased lacrimation (HP:0000633)1.53055641
163Striae distensae (HP:0001065)1.52565071
164Overgrowth (HP:0001548)1.51441921
165Radioulnar synostosis (HP:0002974)1.50875675
166Abnormal foot bone ossification (HP:0010675)1.50785569
167Microtia (HP:0008551)1.50635020
168Nephroblastoma (Wilms tumor) (HP:0002667)1.50453991
169Patellar dislocation (HP:0002999)1.50102946
170Intellectual disability, moderate (HP:0002342)1.49780163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE12.81885124
2BRSK22.65896343
3NTRK32.53006554
4CDK122.51631245
5SIK22.50580966
6FGFR22.39745249
7FES2.27571352
8NEK22.25307135
9MARK12.20849707
10EEF2K2.17472884
11EPHA42.16507257
12TRIB32.02192793
13CCNB11.97106789
14UHMK11.92816447
15MAP3K101.83581937
16MKNK21.81064978
17BUB11.71867756
18PKN21.70616961
19LATS11.69911902
20MKNK11.69856071
21NTRK21.69675377
22PRKCH1.65991951
23CAMK1G1.63940178
24TTK1.63155345
25PAK61.57824710
26PRPF4B1.56496075
27CAMKK11.48540315
28EPHB11.44788918
29PTK61.44689437
30HIPK21.44204075
31CDC71.44167652
32DAPK21.41309557
33EIF2AK11.41170963
34KSR11.40903244
35PDGFRA1.31334894
36AKT31.30282907
37BRSK11.30031673
38SCYL21.29027640
39CLK11.28340074
40MINK11.27972861
41MAP4K11.27960234
42NEK91.27446193
43RET1.24242207
44PNCK1.24205063
45PLK41.22988049
46MAPK131.22817664
47ITK1.22727541
48MAP3K41.22296970
49YES11.21989075
50MAP3K61.21440102
51CDK61.20674414
52SGK31.16695970
53CDK51.15191558
54RIPK11.14926557
55TNIK1.11967970
56CDK191.09337741
57TYRO31.08816323
58PDGFRB1.05845664
59PRKD31.05707371
60MAP3K71.05154967
61BCR1.03829017
62DMPK1.03516079
63MELK1.02738833
64TXK1.02650562
65CASK1.02506232
66RAF10.99107622
67BTK0.98840839
68MARK20.98327676
69TNK20.97173523
70FGFR30.96644815
71ATR0.94438381
72FGFR40.93694411
73HCK0.92889193
74JAK10.92221798
75NEK10.91850807
76TAOK30.91368718
77CDK40.90130050
78SIK30.89003218
79CAMK1D0.88993256
80SYK0.88378118
81NLK0.88238027
82STK30.88158906
83RIPK40.87798755
84MTOR0.87718725
85MAP3K130.87352880
86CHEK10.86966001
87SGK4940.86726133
88SGK2230.86726133
89FYN0.84782502
90CDK30.83217877
91MAPK100.82633133
92SGK20.82571960
93MAP3K20.82494462
94KSR20.79594433
95ATM0.79216114
96KIT0.77598886
97CSNK1A1L0.77304007
98BRD40.77080002
99RPS6KA20.76336751
100CDK10.76263701
101SIK10.76138574
102CDK80.73263713
103ERBB20.72241483
104PRKCQ0.71720683
105AURKB0.71371367
106PKN10.70227915
107NTRK10.69387807
108IRAK20.68579873
109CDK20.66649778
110CAMK10.66616861
111ERBB30.66153741
112ALK0.65997015
113FGFR10.65313109
114ICK0.65149127
115MARK30.65053635
116MAP3K140.64383425
117CSNK1G20.63144554
118CAMKK20.62671735
119PAK20.62638109
120TRPM70.62373682
121CDC42BPA0.61934180
122SRPK10.61309857
123MAP3K120.60938342
124JAK20.60287361
125RPS6KA40.59881655
126RPS6KB20.58663651
127MAP2K70.58410648
128SGK10.58247518
129CHEK20.57310733
130CDK180.57224781
131STK110.57187032
132WNK10.57121249
133PAK30.55920087
134PRKD20.55624990
135LCK0.54984341
136MAPK110.54857772
137PRKD10.54661013
138CDK150.53801274
139DYRK1A0.52971371
140EPHA30.52725138
141GRK60.51995978
142GSK3B0.51669725
143EIF2AK20.51448701
144DYRK1B0.50310380
145CAMK40.50164915
146SRC0.49738120
147CDK11A0.49609068
148MAPK140.49423088
149MAP3K90.49288177
150TTN0.49122239
151MAPKAPK50.49053812
152STK40.46879177
153EPHB20.46770484
154PDK10.45686871
155PLK30.44256343
156PLK20.41009705
157MAPK70.40353048
158PLK10.39948632
159PRKDC0.38480818

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.27195148
2Circadian entrainment_Homo sapiens_hsa047131.85779358
3Olfactory transduction_Homo sapiens_hsa047401.83134099
4Long-term potentiation_Homo sapiens_hsa047201.80875619
5Morphine addiction_Homo sapiens_hsa050321.74899663
6Glutamatergic synapse_Homo sapiens_hsa047241.73874462
7Nicotine addiction_Homo sapiens_hsa050331.69822257
8Non-homologous end-joining_Homo sapiens_hsa034501.61798887
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58696591
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57603557
11Cholinergic synapse_Homo sapiens_hsa047251.57379241
12Dopaminergic synapse_Homo sapiens_hsa047281.55889489
13GABAergic synapse_Homo sapiens_hsa047271.52094522
14Prostate cancer_Homo sapiens_hsa052151.51778787
15Gastric acid secretion_Homo sapiens_hsa049711.49851035
16mRNA surveillance pathway_Homo sapiens_hsa030151.49386473
17Glioma_Homo sapiens_hsa052141.49062608
18Type II diabetes mellitus_Homo sapiens_hsa049301.44224114
19Amphetamine addiction_Homo sapiens_hsa050311.43314529
20Adherens junction_Homo sapiens_hsa045201.41083585
21Non-small cell lung cancer_Homo sapiens_hsa052231.38490852
22Primary immunodeficiency_Homo sapiens_hsa053401.37649886
23Renin secretion_Homo sapiens_hsa049241.37355762
24Thyroid cancer_Homo sapiens_hsa052161.36591881
25Cocaine addiction_Homo sapiens_hsa050301.36045922
26T cell receptor signaling pathway_Homo sapiens_hsa046601.35821297
27Axon guidance_Homo sapiens_hsa043601.34657496
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31554035
29B cell receptor signaling pathway_Homo sapiens_hsa046621.31370549
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31098789
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30916383
32Inositol phosphate metabolism_Homo sapiens_hsa005621.29822909
33Salivary secretion_Homo sapiens_hsa049701.29169532
34Chronic myeloid leukemia_Homo sapiens_hsa052201.26633859
35Insulin secretion_Homo sapiens_hsa049111.25284486
36Small cell lung cancer_Homo sapiens_hsa052221.25044827
37Oxytocin signaling pathway_Homo sapiens_hsa049211.23155028
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22702170
39Oocyte meiosis_Homo sapiens_hsa041141.22470820
40Fanconi anemia pathway_Homo sapiens_hsa034601.21762876
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.20138027
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19132997
43Platelet activation_Homo sapiens_hsa046111.18731694
44Endometrial cancer_Homo sapiens_hsa052131.18560093
45GnRH signaling pathway_Homo sapiens_hsa049121.17330662
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17206187
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16771734
48Hepatitis B_Homo sapiens_hsa051611.16485267
49Long-term depression_Homo sapiens_hsa047301.16479727
50Chemokine signaling pathway_Homo sapiens_hsa040621.15539336
51Synaptic vesicle cycle_Homo sapiens_hsa047211.15336693
52Estrogen signaling pathway_Homo sapiens_hsa049151.12626416
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11997404
54ErbB signaling pathway_Homo sapiens_hsa040121.11735062
55cAMP signaling pathway_Homo sapiens_hsa040241.11206245
56Colorectal cancer_Homo sapiens_hsa052101.09070200
57Gap junction_Homo sapiens_hsa045401.07610907
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06786316
59VEGF signaling pathway_Homo sapiens_hsa043701.03990404
60Renal cell carcinoma_Homo sapiens_hsa052111.03800714
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.02807889
62Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00890119
63Dorso-ventral axis formation_Homo sapiens_hsa043201.00688804
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99906463
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98595351
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98527308
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97547992
68Taste transduction_Homo sapiens_hsa047420.97199981
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96869322
70Pancreatic cancer_Homo sapiens_hsa052120.96049612
71Circadian rhythm_Homo sapiens_hsa047100.95866523
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.95603280
73Osteoclast differentiation_Homo sapiens_hsa043800.94616418
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93434879
75Calcium signaling pathway_Homo sapiens_hsa040200.92867294
76Viral carcinogenesis_Homo sapiens_hsa052030.92406052
77Serotonergic synapse_Homo sapiens_hsa047260.91994020
78Phototransduction_Homo sapiens_hsa047440.91272813
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90430095
80Choline metabolism in cancer_Homo sapiens_hsa052310.89769366
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89011379
82Spliceosome_Homo sapiens_hsa030400.88708412
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87707077
84AMPK signaling pathway_Homo sapiens_hsa041520.87138152
85Melanogenesis_Homo sapiens_hsa049160.85562946
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84302675
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82498232
88ECM-receptor interaction_Homo sapiens_hsa045120.82335035
89Pancreatic secretion_Homo sapiens_hsa049720.82060594
90Pathways in cancer_Homo sapiens_hsa052000.81089381
91Hippo signaling pathway_Homo sapiens_hsa043900.81035496
92Acute myeloid leukemia_Homo sapiens_hsa052210.80929963
93TGF-beta signaling pathway_Homo sapiens_hsa043500.80175349
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80116277
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79356715
96Prolactin signaling pathway_Homo sapiens_hsa049170.78625268
97Rap1 signaling pathway_Homo sapiens_hsa040150.78441847
98MAPK signaling pathway_Homo sapiens_hsa040100.78226437
99Melanoma_Homo sapiens_hsa052180.77641920
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77411174
101Nucleotide excision repair_Homo sapiens_hsa034200.77007240
102DNA replication_Homo sapiens_hsa030300.76780364
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.75959570
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.75726385
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.74443357
106Endocytosis_Homo sapiens_hsa041440.74358268
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74145946
108Lysine degradation_Homo sapiens_hsa003100.73297028
109Focal adhesion_Homo sapiens_hsa045100.73179669
110Thyroid hormone synthesis_Homo sapiens_hsa049180.72093162
111HTLV-I infection_Homo sapiens_hsa051660.70704235
112Basal cell carcinoma_Homo sapiens_hsa052170.70379282
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69431466
114Viral myocarditis_Homo sapiens_hsa054160.69326142
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69228527
116Proteoglycans in cancer_Homo sapiens_hsa052050.66906884
117Homologous recombination_Homo sapiens_hsa034400.66826111
118RNA transport_Homo sapiens_hsa030130.66796133
119Ras signaling pathway_Homo sapiens_hsa040140.66614546
120Dilated cardiomyopathy_Homo sapiens_hsa054140.65130811
121Alcoholism_Homo sapiens_hsa050340.63743210
122HIF-1 signaling pathway_Homo sapiens_hsa040660.63406238
123p53 signaling pathway_Homo sapiens_hsa041150.61805153
124Hedgehog signaling pathway_Homo sapiens_hsa043400.61739169
125Wnt signaling pathway_Homo sapiens_hsa043100.60906252
126mTOR signaling pathway_Homo sapiens_hsa041500.60892644
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.60664059
128Insulin signaling pathway_Homo sapiens_hsa049100.60393757
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60031222
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59826375
131Bladder cancer_Homo sapiens_hsa052190.59128714
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58146736
133Notch signaling pathway_Homo sapiens_hsa043300.57152419
134Leishmaniasis_Homo sapiens_hsa051400.56747688
135Toxoplasmosis_Homo sapiens_hsa051450.56462326
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55828772
137MicroRNAs in cancer_Homo sapiens_hsa052060.55514732
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55451533
139FoxO signaling pathway_Homo sapiens_hsa040680.53552253
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53527743

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